1. Search Result
Search Result
Pathways Recommended: Protein Tyrosine Kinase/RTK
Results for "

ALK tyrosine kinase receptor

" in MCE Product Catalog:

2

Inhibitors & Agonists

1

Screening Libraries

Cat. No. Product Name Target Research Areas
  • HY-15609
    AZD-3463

    ALK/IGF1R inhibitor

    IGF-1R Anaplastic lymphoma kinase (ALK) Autophagy Apoptosis Cancer Endocrinology
    AZD-3463 (ALK/IGF1R inhibitor) is an orally active ALK/IGF1R inhibitor, with a Ki of 0.75 nM for ALK. AZD3463 induces apoptosis and autophagy in neuroblastoma cells.
  • HY-144423
    Trk-IN-10

    Trk Receptor Cancer
    Trk-IN-10 (Compound 14j) is a potent inhibitor of TRK (IC50 = 0.86, 6.92 nM, against TrkA, TrkA G595R, respectively). As a receptor tyrosine kinase (RTK), tropomyosin receptor kinase (Trk) is a key drug target in solid tumors. Trk-IN-10 (IC50 = 350 nM against ALK) has a higher selectivity of Trk inhibition, which may be of great significance for reducing toxicity.