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Isoforms Recommended:	ALK5

Results for "

ALK-5

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Anaplastic lymphoma kinase (ALK) (5) Apoptosis (1) IKK (1) JAK (2) Organoid (5) p38 MAPK (2) TGF-beta/Smad (4) TGF-β Receptor (43)
By Research Areas:	Cancer (41) Cardiovascular Disease (2) Endocrinology (1) Inflammation/Immunology (10) Metabolic Disease (3)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Recombinant Proteins

Targets Recommended: Anaplastic lymphoma kinase (ALK)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-151273

ALK5-IN-27

TGF-β Receptor Cancer

ALK5-IN-27 (Compound EX-04) is a potent ALK-5 inhibitor with an IC₅₀ ≤10 nM. ALK5-IN-27 also inhibits ALK-2 (selectivity ALK2/ALK5 ≤10) .
HY-151283

ALK5-IN-33

TGF-β Receptor Cancer

ALK5-IN-33 (Compound EX-10) is a selective, orally active ALK-5 inhibitor with an IC₅₀ ≤10 nM .
HY-112877

ALK-5-IN-1

TGF-β Receptor Cancer

ALK-5-IN-1 is an ALK-5 inhibitor. ALK-5-IN-1 can be used for the research of cancer, and conditions involving fibrosis .

ALK5-IN-27	TGF-β Receptor	Cancer
ALK5-IN-27 (Compound EX-04) is a potent *ALK-5* inhibitor with an IC₅₀ ≤10 nM. ALK5-IN-27 also inhibits *ALK-2* (selectivity ALK2/ALK5 ≤10) .

ALK5-IN-33	TGF-β Receptor	Cancer
ALK5-IN-33 (Compound EX-10) is a selective, orally active *ALK-5* inhibitor with an IC₅₀ ≤10 nM .

ALK-5-IN-1	TGF-β Receptor	Cancer
ALK-5-IN-1 is an *ALK-5* inhibitor. ALK-5-IN-1 can be used for the research of cancer, and conditions involving fibrosis .

HY-151272

ALK5-IN-26	Others	Cancer
ALK5-IN-26 (EX-22) is an *ALK* (Activin receptor-like kinase) inhibitor. ALK5-IN-26 inhibits ALK5 with an IC₅₀ value ≤10 nM. ALK5-IN-26 can be used for the research of cancer .

HY-151270

ALK5-IN-25	TGF-β Receptor	Cancer
ALK5-IN-25 (compound EX-02) is a potent *ALK-5* inhibitor with an IC₅₀ ≤10 nM.ALK5-IN-25 also inhibits *ALK-2* (selectivity ALK2/ALK5≤10). ALK5-IN-25 can be used for the research of cancer .

HY-144437

ALK5-IN-9	TGF-β Receptor	Cancer
ALK5-IN-9 (Compound 8h) is a potent and orally active inhibitor of TGFβRI (ALK5). ALK5-IN-9 inhibits ALK5 autophosphorylation and NIH3T3 cell activity with IC₅₀ values of 25 nM and 74.6 nM, respectively. ALK5-IN-9 also shows favorable pharmacokinetic profile and ameliorated hERG inhibition. ALK5-IN-9 has the potential for the research of cancer disease .

HY-144043

ALK5-IN-8	TGF-β Receptor	Cancer
ALK5-IN-8 is a potent inhibitor of TGFβRI (ALK5). ALK5-IN-8 Inhibits the phosphorylation of ALK5 on its downstream signaling proteins (Smad2 or Smad3) by blocking the binding of TGFβRI to ligands, thereby affecting or blocking TGF-β signaling. ALK5-IN-8 has the potential for the research of various ALK5-mediated related diseases (extracted from patent WO2021190425A1, compound 1) .

HY-151277

ALK5-IN-29	Anaplastic lymphoma kinase (ALK)	Cancer
ALK5-IN-29 is an selective activin receptor-like kinase (ALK) inhibitor. ALK5-IN-29 can inhibit the activity of ALK5 with an IC₅₀ value of ≤10 nM. ALK5-IN-29 also has inhibitory of tumor growth and can be used for the research of proliferative diseases, such as cancer .

HY-151289

ALK5-IN-34	TGF-β Receptor TGF-beta/Smad	Cancer
ALK5-IN-34 is an selective orally active activin receptor-like kinase (ALK) inhibitor. ALK5-IN-34 can inhibit the activity of ALK5-IN-34 with an IC₅₀ value of ≤10 nM. ALK5-IN-34 also has inhibitory of tumor growth and can be used for the research of proliferative diseases, such as cancer .

HY-151233

ALK5-IN-10	TGF-β Receptor	Cancer
ALK5-IN-10 (Compound 5d) is a TGF-β type I receptor kinase *ALK5* inhibitor, with IC₅₀s of 0.007 and 1.98 μM for ALK5 and p38α, respectively. ALK5-IN-10 can be used for the research of cancer .

HY-151275

ALK5-IN-28	TGF-β Receptor TGF-beta/Smad	Cancer
ALK5-IN-28 (compound Ex-05) is a selective *ALK-5* inhibitor (IC₅₀≤10 nM), inhibits TGF-β-induced SMAD signaling. ALK5-IN-28 has the potential to inhibit growth of tumour in vivo. ALK5-IN-28 can be used in study of proliferative diseases such as cancer, fibrotic diseases, and systemic sclerosis .

HY-151281

ALK5-IN-31	TGF-β Receptor	Cancer
ALK5-IN-31 (compound Ex-08) is a selective *ALK-5* inhibitor (IC₅₀≤10 nM), inhibits TGF-β-induced SMAD signaling. ALK5-IN-31 has the potential to inhibit growth of tumour in vivo. ALK5-IN-31 can be used in study of proliferative diseases such as cancer, fibrotic diseases, and systemic sclerosis .

HY-151282

ALK5-IN-32	TGF-β Receptor TGF-beta/Smad	Cancer
ALK5-IN-32 (compound EX-09) is a selective *ALK-5* inhibitor (10 nM<IC₅₀<100 nM), inhibits TGF-β-induced SMAD signaling. ALK5-IN-32 has the potential to inhibit growth of tumour in vivo. ALK5-IN-32 can be used in study of proliferative diseases such as cancer, fibrotic diseases, and systemic sclerosis .

HY-151279

ALK5-IN-30

Anaplastic lymphoma kinase (ALK) Cancer

ALK5-IN-30 (EX-07) is a potent ALK inhibitor, inhibits ALK5 and TGFβ-R1 with both IC₅₀s <10 nM .

ALK5-IN-30	Anaplastic lymphoma kinase (ALK)	Cancer
ALK5-IN-30 (EX-07) is a potent *ALK* inhibitor, inhibits *ALK5* and TGFβ-R1 with both IC₅₀s <10 nM .

HY-142949

ALK5-IN-7	TGF-β Receptor	Inflammation/Immunology Cancer
ALK5-IN-7 is a potent inhibitor of *ALK5. Transforming growth factor beta (TGF-β) is a multifunctional cytokine that is involved in regulating cell proliferation, differentiation and apoptosis through complex receptor signaling pathways on the cell surface in an autocrine, paracrine and endocrine manner. ALK5*-IN-7 has the potential for the research of TGF-β-related diseases and conditions, including but not limited to tumors, fibrotic diseases, inflammatory diseases, autoimmune diseases, etc (extracted from patent WO2021129621A1, compound 4) .

HY-142950

ALK5-IN-6	TGF-β Receptor	Inflammation/Immunology Cancer
ALK5-IN-6 is a potent inhibitor of *ALK5. Transforming growth factor beta (TGF-β) is a multifunctional cytokine that is involved in regulating cell proliferation, differentiation and apoptosis through complex receptor signaling pathways on the cell surface in an autocrine, paracrine and endocrine manner. ALK5*-IN-6 has the potential for the research of TGF-β-related diseases and conditions, including but not limited to tumors, fibrotic diseases, inflammatory diseases, autoimmune diseases, etc (extracted from patent WO2021129621A1, compound 1) .

HY-111482

SM 16

TGF-β Receptor Cardiovascular Disease Inflammation/Immunology Cancer

SM 16 is a ALK5/ALK4 kinase inhibitor with K_is of 10 and 1.5 nM, respectively.

SM 16	TGF-β Receptor	Cardiovascular Disease Inflammation/Immunology Cancer
SM 16 is a *ALK5/ALK4* kinase inhibitor with K_is of 10 and 1.5 nM, respectively.

HY-18758

IN-1130
IN-1130 is a highly selective transforming growth factor-β type I receptor kinase (ALK5) inhibitor with an IC₅₀ of 5.3 nM for ALK5-mediated Smad3 phosphorylation. IN-1130 inhibits ALK5 phosphorylation of casein (IC₅₀=36 nM) and p38α mitogen-activated protein kinase (IC₅₀=4.3 μM). IN-1130 suppresses renal fibrosis in obstructive nephropathy and blocks breast cancer lung metastasis .

HY-10432A

A 83-01 sodium 35+ Cited Publications	Organoid TGF-β Receptor	Cancer
A 83-01 sodium is a potent inhibitor of *TGF-β type I receptor ALK5* kinase, ALK4 and ALK7, with IC₅₀s of 12 nM, 45 nM and 7.5 nM against the transcription induced by ALK5, ALK4 and ALK7**, respectively .

HY-13227

SD-208

5+ Cited Publications

TGF-β Receptor Cancer

SD-208 is a selective TGF-βRI (ALK5) inhibitor with IC₅₀ of 48 nM, and > 100-fold selectivity over TGF-βRII.
HY-109179A

Itacnosertib (hydrocholide)

TP-0184 (hydrocholide)
JAK TGF-β Receptor Cancer

Itacnosertib hydrocholide is an inhibitor of JAK2, ACVR1 (ALK2) and ALK5 .

SD-208 5+ Cited Publications	TGF-β Receptor	Cancer
SD-208 is a selective TGF-βRI (ALK5) inhibitor with IC₅₀ of 48 nM, and > 100-fold selectivity over TGF-βRII.

Itacnosertib (hydrocholide) TP-0184 (hydrocholide)	JAK TGF-β Receptor	Cancer
Itacnosertib hydrocholide is an inhibitor of JAK2, ACVR1 (ALK2) and *ALK5* .

HY-13521

SB-505124 10+ Cited Publications	TGF-β Receptor	Cancer
SB-505124 is a selective inhibitor of TGF-β Receptor type I receptors (ALK4, *ALK5, ALK7), with IC₅₀s of 129 nM and 47 nM for ALK4, ALK5, respectively, but it does not inhibit ALK*1, 2, 3, or 6.

HY-13521A

SB-505124 hydrochloride 10+ Cited Publications	TGF-β Receptor	Cancer
SB-505124 hydrochloride is a selective inhibitor of TGF-β Receptor type I receptor (ALK4, *ALK5, ALK7), with IC₅₀s of 129 nM and 47 nM for ALK4, ALK5, respectively, but it does not inhibit ALK*1, 2, 3, or 6.

HY-10432

A 83-01 35+ Cited Publications	Organoid TGF-β Receptor	Cancer
A 83-01 is a potent inhibitor of TGF-β type I receptor ALK5 kinase, type I nodal receptor *ALK4* and type I nodal receptor *ALK7, with IC₅₀s of 12 nM, 45 nM and 7.5 nM against the transcription induced by ALK5, ALK4* and *ALK7*, respectively .

HY-13012

RepSox 15+ Cited Publications E-616452; SJN 2511	Organoid TGF-β Receptor	Metabolic Disease
RepSox (E-616452) is a potent and selective transforming growth factor-beta receptor I/activin like kinase 5 (TGF-β-RI/ALK5) inhibitor. RepSox inhibits ALK5 autophosphorylation with an IC₅₀ value of 4 nM. RepSox can be used for the research of obesity and associated metabolic diseases such as type 2 diabetes .

HY-12043

SB 525334

5+ Cited Publications

TGF-β Receptor Cancer

SB 525334 is a potent and selective transforming growth factor β1 receptor (ALK5) inhibitor with an IC₅₀ of 14.3 nM.
HY-13783

BIBF0775

TGF-β Receptor Cancer

BIBF0775 is a potent and selective transforming growth factor β (TGFβ) type I receptor (Alk5) inhibitor with an IC₅₀ of 34 nM.
HY-109179

Itacnosertib

TP-0184
JAK TGF-β Receptor Cancer

Itacnosertib (TP-0184) is both inhibitor to JAK2, ACVR1 (ALK2) and ALK5 as described in WO2014151871 .

SB 525334 5+ Cited Publications	TGF-β Receptor	Cancer
SB 525334 is a potent and selective transforming growth factor β1 receptor *(ALK5)* inhibitor with an IC₅₀ of 14.3 nM.

BIBF0775	TGF-β Receptor	Cancer
BIBF0775 is a potent and selective transforming growth factor β (TGFβ) type I receptor (Alk5) inhibitor with an IC₅₀ of 34 nM.

Itacnosertib TP-0184	JAK TGF-β Receptor	Cancer
Itacnosertib (TP-0184) is both inhibitor to JAK2, ACVR1 (ALK2) and *ALK5* as described in WO2014151871 .

HY-10327

GW-6604	TGF-β Receptor	Metabolic Disease
GW-6604 is an *ALK5* inhibitor with an IC₅₀ value of 140 nM for inhibiting its autophosphorylation, and can be used in the study of liver fibrosis .

HY-18766

EW-7195	TGF-β Receptor p38 MAPK	Cancer
EW-7195 is a potent and selective ALK5 (TGFβR1) inhibitor with an IC₅₀ of 4.83 nM. EW-7195 has >300-fold selectivity for ALK5 over p38α. EW-7195 efficiently inhibits TGF-β1-induced Smad signaling, epithelial-to-mesenchymal transition (EMT) and breast tumour metastasis to the lung .

HY-78349

A 77-01 1 Publications Verification	TGF-β Receptor	Cancer
A 77-01 is a potent inhibitor of transforming growth factor (TGF)-β type I receptor superfamily activin-like kinase ALK5 with an IC₅₀ of 25 nM .

HY-129171

TGFBR1-IN-1

TGF-β Receptor Inflammation/Immunology Cancer

TGFBR1-IN-1 is an ALK5 inhibitor extracted from patent WO2018004290A1, Compound 33, has an IC₅₀ of 10-100 nM .

TGFBR1-IN-1	TGF-β Receptor	Inflammation/Immunology Cancer
TGFBR1-IN-1 is an *ALK5* inhibitor extracted from patent WO2018004290A1, Compound 33, has an IC₅₀ of 10-100 nM .

HY-150169

THRX-144644	TGF-β Receptor	Cancer
THRX-144644 is a Lung-restricted *ALK5* inhibitor with an IC₅₀ value of 0.14 nM. THRX-144644 avoids systemic toxicities associated with TGFβ pathway inhibition .

HY-10326

GW788388 10+ Cited Publications	TGF-β Receptor	Cancer
GW788388 is a potent and selective inhibitor of *ALK5* with IC₅₀ of 18 nM, and also inhibits TGF-β type II receptor and activin type II receptor activities, without inhibiting BMP type II receptor.

HY-12953

R-268712	TGF-β Receptor TGF-beta/Smad Anaplastic lymphoma kinase (ALK)	Cardiovascular Disease Inflammation/Immunology Cancer
R-268712 is an orally active and selective *ALK-5* inhibitor, with an IC₅₀ of 2.5 nM. R-268712 inhibits the phosphorylation of Smad3 in a dose-dependent manner with an IC₅₀ of 10.4 nM. R-268712 suppresses glomerulonephritis as well as glomerulosclerosis by inhibiting TGF-β signaling, which can be used in studies of renal fibrosis and cancer .

HY-149403

J-1048	Anaplastic lymphoma kinase (ALK)	Others
J-1048 is an activin receptor-like kinase 5 *(ALK5)* inhibitor. J-1048 can inhibit TAA-induced liver fibrosis in mice by explicitly blocking the TGF-β/Smad signaling pathway .

HY-118528

TP0427736	TGF-β Receptor	Cancer
TP0427736 is a selective inhibitor of *ALK5* with an IC₅₀ of 2.72 nM. TP0427736 inhibits Smad2/3 phosphorylation in A549 cells. TP0427736 decreases the growth inhibition of human outer root sheath cells .

HY-103021

LY3200882 5+ Cited Publications	TGF-β Receptor	Inflammation/Immunology Cancer
LY3200882 is a potent, highly selective, ATP-competitive and orally active TGF-β receptor type 1 (ALK5) inhibitor with an IC₅₀ of 38.2 nM. LY3200882 inhibits various pro-tumorigenic activities and is also used as an immune modulatory agent .

HY-13012G

RepSox E-616452; SJN 2511	TGF-β Receptor	Metabolic Disease
RepSox (E-616452) (GMP) is a RepSox (HY-13012) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. RepSox is a potent and selective TGF-β-RI/ALK5 inhibitor .

HY-12071A

LDN193189 Tetrahydrochloride 45+ Cited Publications DM-3189 Tetrahydrochloride	Organoid TGF-β Receptor	Cancer
LDN193189 Tetrahydrochloride is a selective BMP type I receptor inhibitor, which efficiently inhibits *ALK2* and *ALK3* (IC₅₀=5 nM and 30 nM, respectively), with weaker effects on ALK4, ALK5 and ALK7 (IC₅₀≥500 nM) .

HY-125851

TP-008	TGF-β Receptor	Inflammation/Immunology
TP-008 is a potent, selective and orally active (Activin-Like Kinase 5) ALK5 inhibitor with pIC₅₀ and pEC₅₀ values of 7.6 and 6.63, respectively. TGFβRI-IN-2 can produce observed cardiac toxicity in vivo at high dose .

HY-145855

J-1063	TGF-β Receptor	Inflammation/Immunology
J-1063 is a potent, selective and orally active *ALK5* inhibitor with an IC₅₀ of 0.039 µM. J-1063 shows anti-fibrotic effect by the inhibition of inflammatory infiltration, collagen deposition, and hepatocytes necrosis. J-1063 has the potential for the research of liver fibrosis .

HY-163429

J-1149	TGF-β Receptor p38 MAPK	Inflammation/Immunology Cancer
J-1149 is a potent *ALK5* inhibitor, with an IC₅₀ value of 0.017 μM. J-1149 also shows weak p38α MAP kinase inhibitory activity, with an IC₅₀ value of 0.435 μM. J-1149 can be used for liver fibrosis research .

HY-19928

Vactosertib 3 Publications Verification EW-7197; TEW-7197	TGF-β Receptor	Cancer
Vactosertib (EW-7197) is a potent, orally active and ATP-competitive activin receptor-like kinase 5 (ALK5) inhibitor with an IC₅₀ of 12.9 nM. Vactosertib also inhibits ALK2 and ALK4 (IC₅₀ of 17.3 nM) at nanomolar concentrations. Vactosertib has potently antimetastatic activity and anticancer effect .

HY-19928A

Vactosertib Hydrochloride 3 Publications Verification EW-7197 Hydrochloride; TEW-7197 Hydrochloride	TGF-β Receptor	Cancer
Vactosertib Hydrochloride (EW-7197 Hydrochloride) is a potent, orally active and ATP-competitive activin receptor-like kinase 5 (ALK5) inhibitor with an IC₅₀ of 12.9 nM. Vactosertib Hydrochloride also inhibits ALK2 and ALK4 (IC₅₀ of 17.3 nM) at nanomolar concentrations. Vactosertib Hydrochloride has potently antimetastatic activity and anticancer effect .

HY-146780

TGFβRI-IN-4	TGF-β Receptor	Cancer
TGFβRI-IN-4 is a highly potent and orally active TGFβ receptor type I (TGFβRI) inhibitor, with IC₅₀s of 44 nM and 42.5 nM for ALK5 and NIH3T3. TGFβRI-IN-4 can suppress tumor growth and tumor weight in tumor xenograft model .

HY-148234

M4K2234	Anaplastic lymphoma kinase (ALK)	Cancer
M4K2234 (compound 26b) is an *ALK2* inhibitor. M4K2234 inhibits ALK2 and ALK5 with IC₅₀s of 5 and 2144 nM, respectively. M4K2234 can be used as a chemical probe for ALK1 and ALK2 protein kinases. M4K2234 can be used for the research of cancer .

HY-10431

SB-431542 Maximum Cited Publications 162 Publications Verification	Organoid TGF-β Receptor Apoptosis	Cancer
SB-431542 is a TGF-β receptor kinase inhibitor (TRKI). SB-431542 has inhibitory activity for ALK4, ALK5 and ALK7 with IC₅₀ values of 1 μM, 0.75 μM and 2 μM, respectively. SB-431542 also inhibits TGF-β-induced transcription, gene expression, apoptosis, and growth suppression. SB-431542 can be used for the research of cancer and signal transduction pathways .

HY-135366

HPN-01	IKK	Inflammation/Immunology
HPN-01 is a potent and selective IKK inhibitor, with pIC₅₀ values of 6.4, 7.0 and <4.8 for IKK-α, IKK-β and IKK-ε, respectively. HPN-01 displays greater 50-fold selectivity over a panel of more than 50 other kinases, including ALK5, CDK-2, EGFR, ErbB2, GSK3β, PLK1, Src, and VEGFR-2 .

HY-118528A

TP0427736 hydrochloride	TGF-β Receptor	Endocrinology
TP0427736 hydrochloride is a potent inhibitor of *ALK5* kinase activity with an IC₅₀ of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC₅₀=836 nM). TP0427736 hydrochloride also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC₅₀ value of 8.68 nM. TP0427736 hydrochloride can be used for the research of androgenic alopecia (AGA) .

Cat. No.	Product Name	Type

HY-13012G

RepSox (GMP) E-616452 (GMP); SJN 2511 (GMP)	Fluorescent Dye
RepSox (E-616452) (GMP) is a RepSox (HY-13012) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. RepSox is a potent and selective TGF-β-RI/ALK5 inhibitor .

Cat. No.	Product Name	Type

HY-13012G

RepSox (GMP) E-616452 (GMP); SJN 2511 (GMP)	Biochemical Assay Reagents
RepSox (E-616452) (GMP) is a RepSox (HY-13012) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. RepSox is a potent and selective TGF-β-RI/ALK5 inhibitor .

Species:	Human (4) Mouse (1)
Tag:	His (2) Avi (1) GST (1) Fc (4)
Source:	HEK293 (4) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P78525

	*TGFBR1/ALK-5* Protein, Human (HEK293, mFc-Avi)** AAT5; ACVRLK4; ALK-5; LDS1A; LDS2A; SKR4; tbetaR-I; TGFB1R1; TGF-beta RI; TGFbetaRI; TGFBR1; TGF-bRI; TGFR-1; tβR-I; TGF-β RI; TGFβRI	Human	HEK293
	TGFBR1/ALK-5 proteins cooperate with TGFBR2 to form dedicated receptors for TGFB1, TGFB2, and TGFB3, transmitting signals and coordinating different physiological and pathological processes. It induces cell cycle arrest, modulates mesenchymal cell dynamics, contributes to wound healing, and affects immunosuppression and carcinogenesis. TGFBR1/ALK-5 Protein, Human (HEK293, mFc-Avi) is the recombinant human-derived TGFBR1/ALK-5 protein, expressed by HEK293 , with C-Avi, C-mFc labeled tag. The total length of TGFBR1/ALK-5 Protein, Human (HEK293, mFc-Avi) is 92 a.a., with molecular weight of 50-60 kDa.

HY-P74522

	*TGFBR1/ALK-5* Protein, Human (sf9, His-GST)** TGF-beta receptor type-1; ALK-5; SKR4; TbetaR-I; AAT5	Human	Sf9 insect cells
	TGFBR1/ALK-5 proteins cooperate with TGFBR2 to form dedicated receptors for TGFB1, TGFB2, and TGFB3, transmitting signals and coordinating different physiological and pathological processes. It induces cell cycle arrest, modulates mesenchymal cell dynamics, contributes to wound healing, and affects immunosuppression and carcinogenesis. TGFBR1/ALK-5 Protein, Human (sf9, His-GST) is the recombinant human-derived TGFBR1/ALK-5 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of TGFBR1/ALK-5 Protein, Human (sf9, His-GST) is 304 a.a., with molecular weight of ~57 kDa.

HY-P72454

	*TGFBR1/ALK-5* Protein, Mouse (HEK293, Fc)** TGF-beta receptor type-1; ALK-5; SKR4; TbetaR-I; AAT5	Mouse	HEK293
	TGFBR1 is a transmembrane kinase that cooperates with TGFBR2 to form the TGF-β receptor complex. This complex is activated by cytokines and regulates a variety of processes, including cell cycle arrest, mesenchymal cell control, wound healing, and carcinogenesis. TGFBR1/ALK-5 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived TGFBR1/ALK-5 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TGFBR1/ALK-5 Protein, Mouse (HEK293, Fc) is 96 a.a., with molecular weight of 40-60 kDa.

HY-P72453

	*TGFBR1/ALK-5* Protein, Human (HEK293, Fc)** TGF-beta receptor type-1; ALK-5; SKR4; TbetaR-I; AAT5	Human	HEK293
	TGFBR1/ALK-5 proteins cooperate with TGFBR2 to form dedicated receptors for TGFB1, TGFB2, and TGFB3, transmitting signals and coordinating different physiological and pathological processes. It induces cell cycle arrest, modulates mesenchymal cell dynamics, contributes to wound healing, and affects immunosuppression and carcinogenesis. TGFBR1/ALK-5 Protein, Human (HEK293, Fc) is the recombinant human-derived TGFBR1/ALK-5 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TGFBR1/ALK-5 Protein, Human (HEK293, Fc) is 92 a.a., with molecular weight of ~55 kDa.

HY-P74523

	*TGFBR1/ALK-5* Protein, Human (HEK293, His-Fc)** TGF-beta receptor type-1; ALK-5; SKR4; TbetaR-I; AAT5	Human	HEK293
	TGFBR1/ALK-5 proteins cooperate with TGFBR2 to form dedicated receptors for TGFB1, TGFB2, and TGFB3, transmitting signals and coordinating different physiological and pathological processes. It induces cell cycle arrest, modulates mesenchymal cell dynamics, contributes to wound healing, and affects immunosuppression and carcinogenesis. TGFBR1/ALK-5 Protein, Human (HEK293, His-Fc) is the recombinant human-derived TGFBR1/ALK-5 protein, expressed by HEK293 , with C-hFc, C-His labeled tag. The total length of TGFBR1/ALK-5 Protein, Human (HEK293, His-Fc) is 92 a.a., with molecular weight of 45-50 kDa.

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