Search Result

Targets Recommended:	IGF-1R c-Fms IRAK PERK

Results for "AMPA R Inhibitors" in MCE Product Catalog:

By Targets:	c-Fms (17) IGF-1R (17) PERK (2) 5-HT Receptor (22) AChE (1) ADC Cytotoxin (1) ADC Linker (2) Adenosine Receptor (2) Adenylate Cyclase (1) Adrenergic Receptor (19) Akt (2) ALK (8) Aminoacyl-tRNA Synthetase (1) Amyloid-β (2) Androgen Receptor (2) Angiotensin Receptor (10) Antibiotic (12) Apoptosis (41) ATP Synthase (2) Aurora Kinase (2) Autophagy (38) Bacterial (21) Bcl-2 Family (3) Bcr-Abl (6) BMX Kinase (1) Bradykinin Receptor (1) Btk (2) c-Kit (7) c-Met/HGFR (3) Calcium Channel (12) CaMK (2) Cannabinoid Receptor (7) Carbonic Anhydrase (2) Casein Kinase (1) CaSR (1) CCR (4) CDK (7) CFTR (3) Chloride Channel (1) COX (2) CRFR (3) CRISPR/Cas9 (1) CXCR (3) Cytochrome P450 (7) Discoidin Domain Receptor (2) DNA-PK (1) DNA/RNA Synthesis (4) Dopamine Receptor (23) Drug Metabolite (7) Drug-Linker Conjugates for ADC (1) DYRK (3) E3 Ligase Ligand-Linker Conjugate (39) EGFR (41) Endogenous Metabolite (43) Enterovirus (1) Ephrin Receptor (1) Epigenetic Reader Domain (4) Estrogen Receptor/ERR (2) Factor Xa (2) FAK (1) Farnesyl Transferase (2) Ferroptosis (7) FGFR (2) FLT3 (5) Fungal (15) GABA Receptor (8) GHSR (3) Glucagon Receptor (6) GLUT (1) Glutathione Peroxidase (1) GlyT (1) GNRH Receptor (4) GPCR19 (1) GSK-3 (3) HCV (8) HCV Protease (1) Hedgehog (1) HIF/HIF Prolyl-Hydroxylase (1) Histamine Receptor (18) Histone Methyltransferase (8) HIV (16) HIV Integrase (2) HMG-CoA Reductase (HMGCR) (5) HSV (3) iGluR (47) IKK (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Influenza Virus (3) Insulin Receptor (9) Integrin (2) Interleukin Related (3) Isocitrate Dehydrogenase (IDH) (15) JAK (2) JNK (1) Keap1-Nrf2 (1) Kinesin (1) Lactate Dehydrogenase (2) Ligand for E3 Ligase (10) LIM Kinase (LIMK) (1) LPL Receptor (3) LXR (1) mAChR (4) MAP3K (1) MCHR1 (GPR24) (5) MDM-2/p53 (1) MEK (3) Melanocortin Receptor (19) mGluR (7) Microtubule/Tubulin (2) Mitochondrial Metabolism (2) MMP (5) Monoamine Oxidase (2) Monoamine Transporter (2) mTOR (2) Na+/Ca2+ Exchanger (1) nAChR (2) Neurokinin Receptor (8) Neuropeptide Y Receptor (4) NF-κB (3) Opioid Receptor (4) Orexin Receptor (OX Receptor) (8) Oxytocin Receptor (4) P-glycoprotein (5) P2X Receptor (3) P2Y Receptor (1) p38 MAPK (3) Parasite (10) PARP (2) PDGFR (4) PDK-1 (1) Phosphatase (5) Phosphodiesterase (PDE) (8) PI3K (3) Pim (2) PKA (2) PKC (2) Potassium Channel (10) PPAR (1) PROTAC (4) PROTAC Linker (4) Proteasome (1) Proton Pump (1) Pyk2 (1) Pyruvate Kinase (2) Raf (1) RAR/RXR (3) Reactive Oxygen Species (6) RET (2) Reverse Transcriptase (7) ROR (1) ROS (5) RSV (1) SARS-CoV (3) Ser/Thr Protease (1) SGK (1) Sigma Receptor (10) Sirtuin (2) Sodium Channel (5) Somatostatin Receptor (2) Src (2) STAT (5) Syk (6) TAM Receptor (2) TGF-β Receptor (1) Thrombin (1) Thyroid Hormone Receptor (2) TNF Receptor (2) Toll-like Receptor (TLR) (6) Topoisomerase (3) TRP Channel (5) Tyrosinase (3) Vasopressin Receptor (2) VD/VDR (5) VEGFR (8) Virus Protease (1)
By Research Areas:	Cancer (334) Cardiovascular Disease (55) Endocrinology (98) Infection (68) Inflammation/Immunology (110) Metabolic Disease (76) Neurological Disease (216)

By Targets:

c-Fms (17)

IGF-1R (17)

PERK (2)

5-HT Receptor (22)

AChE (1)

ADC Cytotoxin (1)

ADC Linker (2)

Adenosine Receptor (2)

Adenylate Cyclase (1)

Adrenergic Receptor (19)

Akt (2)

ALK (8)

Aminoacyl-tRNA Synthetase (1)

Amyloid-β (2)

Androgen Receptor (2)

Angiotensin Receptor (10)

Antibiotic (12)

Apoptosis (41)

ATP Synthase (2)

Aurora Kinase (2)

Autophagy (38)

Bacterial (21)

Bcl-2 Family (3)

Bcr-Abl (6)

BMX Kinase (1)

Bradykinin Receptor (1)

Btk (2)

c-Kit (7)

c-Met/HGFR (3)

Calcium Channel (12)

CaMK (2)

Cannabinoid Receptor (7)

Carbonic Anhydrase (2)

Casein Kinase (1)

CaSR (1)

CCR (4)

CDK (7)

CFTR (3)

Chloride Channel (1)

COX (2)

CRFR (3)

CRISPR/Cas9 (1)

CXCR (3)

Cytochrome P450 (7)

Discoidin Domain Receptor (2)

DNA-PK (1)

DNA/RNA Synthesis (4)

Dopamine Receptor (23)

Drug Metabolite (7)

Drug-Linker Conjugates for ADC (1)

DYRK (3)

E3 Ligase Ligand-Linker Conjugate (39)

EGFR (41)

Endogenous Metabolite (43)

Enterovirus (1)

Ephrin Receptor (1)

Epigenetic Reader Domain (4)

Estrogen Receptor/ERR (2)

Factor Xa (2)

FAK (1)

Farnesyl Transferase (2)

Ferroptosis (7)

FGFR (2)

FLT3 (5)

Fungal (15)

GABA Receptor (8)

GHSR (3)

Glucagon Receptor (6)

GLUT (1)

Glutathione Peroxidase (1)

GlyT (1)

GNRH Receptor (4)

GPCR19 (1)

GSK-3 (3)

HCV (8)

HCV Protease (1)

Hedgehog (1)

HIF/HIF Prolyl-Hydroxylase (1)

Histamine Receptor (18)

Histone Methyltransferase (8)

HIV (16)

HIV Integrase (2)

HMG-CoA Reductase (HMGCR) (5)

HSV (3)

iGluR (47)

IKK (1)

Indoleamine 2,3-Dioxygenase (IDO) (1)

Influenza Virus (3)

Insulin Receptor (9)

Integrin (2)

Interleukin Related (3)

Isocitrate Dehydrogenase (IDH) (15)

JAK (2)

JNK (1)

Keap1-Nrf2 (1)

Kinesin (1)

Lactate Dehydrogenase (2)

Ligand for E3 Ligase (10)

LIM Kinase (LIMK) (1)

LPL Receptor (3)

LXR (1)

mAChR (4)

MAP3K (1)

MCHR1 (GPR24) (5)

MDM-2/p53 (1)

MEK (3)

Melanocortin Receptor (19)

mGluR (7)

Microtubule/Tubulin (2)

Mitochondrial Metabolism (2)

MMP (5)

Monoamine Oxidase (2)

Monoamine Transporter (2)

mTOR (2)

Na+/Ca2+ Exchanger (1)

nAChR (2)

Neurokinin Receptor (8)

Neuropeptide Y Receptor (4)

NF-κB (3)

Opioid Receptor (4)

Orexin Receptor (OX Receptor) (8)

Oxytocin Receptor (4)

P-glycoprotein (5)

P2X Receptor (3)

P2Y Receptor (1)

p38 MAPK (3)

Parasite (10)

PARP (2)

PDGFR (4)

PDK-1 (1)

Phosphatase (5)

Phosphodiesterase (PDE) (8)

PI3K (3)

Pim (2)

PKA (2)

PKC (2)

Potassium Channel (10)

PPAR (1)

PROTAC (4)

PROTAC Linker (4)

Proteasome (1)

Proton Pump (1)

Pyk2 (1)

Pyruvate Kinase (2)

Raf (1)

RAR/RXR (3)

Reactive Oxygen Species (6)

RET (2)

Reverse Transcriptase (7)

ROR (1)

ROS (5)

RSV (1)

SARS-CoV (3)

Ser/Thr Protease (1)

SGK (1)

Sigma Receptor (10)

Sirtuin (2)

Sodium Channel (5)

Somatostatin Receptor (2)

Src (2)

STAT (5)

Syk (6)

TAM Receptor (2)

TGF-β Receptor (1)

Thrombin (1)

Thyroid Hormone Receptor (2)

TNF Receptor (2)

Toll-like Receptor (TLR) (6)

Topoisomerase (3)

TRP Channel (5)

Tyrosinase (3)

Vasopressin Receptor (2)

VD/VDR (5)

VEGFR (8)

Virus Protease (1)

By Research Areas:

Cancer (334)

Cardiovascular Disease (55)

Endocrinology (98)

Infection (68)

Inflammation/Immunology (110)

Metabolic Disease (76)

Neurological Disease (216)

816

Inhibitors & Agonists

Screening Libraries

Dye Reagents

Peptides

Inhibitory Antibodies

102

Natural
Products

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas

HY-100815B

(RS)-AMPA (±)-AMPA	iGluR	Neurological Disease
(RS)-AMPA ((±)-AMPA) is a glutamate analogue and a potent and selective excitatory neurotransmitter L-glutamic acid agonist. (RS)-AMPA does not interfere with binding sites for kainic acid or NMDA receptors.

HY-112699

AMPA receptor modulator-1	iGluR	Neurological Disease
AMPA receptor modulator-1 is a potent, orally active and selective AMPAR regulatory protein TARP γ-8 negative modulator with a pIC₅₀ of 9.7, more selective over GluA1/γ-2 (pIC₅₀=5).

HY-19778

(R)-BPO-27
CFTR Autophagy Inflammation/Immunology

(R)-BPO-27, the R enantiomer of BPO-27, is a potent, orally active and ATP-competitive CFTR inhibitor with an IC₅₀ of 4 nM.

(R)-BPO-27	CFTR Autophagy	Inflammation/Immunology
(R)-BPO-27, the R enantiomer of BPO-27, is a potent, orally active and ATP-competitive CFTR inhibitor with an IC₅₀ of 4 nM.

HY-136165

(S,R,S)-AHPC-PEG3-propionic acid	E3 Ligase Ligand-Linker Conjugate	Cancer
(S,R,S)-AHPC-PEG3-propionic acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.

HY-15071

YM90K	iGluR	Neurological Disease
YM90K is a potent and selective AMPA receptor antagonist with a K_i of 84 nM. YM90K is less potent in inhibiting kainate (K_i of 2.2 μM) and NMDA (K_i of 37 μM) receptors. YM90K has neuroprotective actions.

HY-B0761

*(R,R)-Glycopyrrolate* (R,R)-Glycopyrronium bromide; (R,R)-Glycopyrrolate bromide	mAChR	Neurological Disease
(R,R)-Glycopyrrolate ((R,R)-Glycopyrronium (bromide); (R,R)-Glycopyrrolate (bromide)) is an anticholinergic agent. (R,R)-Glycopyrrolate ((R,R)-Glycopyrronium (bromide); (R,R)-Glycopyrrolate (bromide)) has the ability to reduce the frequency of drooling in vivo with developmental disabilities.

HY-N6937

*(R,R)-Secoisolariciresinol diglucoside* (R,R)-SDG; (R,R)-LGM2605	Others	Inflammation/Immunology
(R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is the minor isomer of Secoisolariciresinol diglucoside in flaxseed. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) possesses antioxidant and free radical scavenging activities and DNA-radioprotective properties. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) inhibits myeloperoxidase (MPO) activity by suppressing both the peroxidase and chlorination cyclesin inflammatory cells.

HY-U00439

Protein kinase inhibitors 1
DYRK Cancer

Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC₅₀ of 74 nM and K_d of 9.5 nM.

*Protein kinase inhibitors* 1**	DYRK	Cancer
Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC₅₀ of 74 nM and K_d of 9.5 nM.

HY-116463C

(2R,3R)-E1R	Sigma Receptor	Neurological Disease
(2R,3R)-E1R (Compound 2b) is an enantiomer of E1R. (2R,3R)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders.

HY-15066

CNQX FG9065	iGluR	Neurological Disease
CNQX (FG9065) is a potent and competitive AMPA/kainate receptor antagonist with IC₅₀s of 0.3 μM and 1.5 μM, respectively. CNQX is a competitive non-NMDA receptor antagonist. CNQX blocks the expression of fear-potentiated startle in rats.

HY-14658B

(R)-Thalidomide
(R)-(+)-Thalidomide
Others Metabolic Disease

(R)-Thalidomide ((R)-(+)-Thalidomide) is the R-enantiomer of Thalidomide. (R)-Thalidomide has sedative properties.
HY-59125

(R,R)-(+)-Hydrobenzoin
Endogenous Metabolite Others

(R,R)-(+)-Hydrobenzoin is a organocatalysts.

(R)-Thalidomide (R)-(+)-Thalidomide	Others	Metabolic Disease
(R)-Thalidomide ((R)-(+)-Thalidomide) is the R-enantiomer of Thalidomide. (R)-Thalidomide has sedative properties.

*(R,R)-(+)-Hydrobenzoin*	Endogenous Metabolite	Others
(R,R)-(+)-Hydrobenzoin is a organocatalysts.

HY-15066A

CNQX disodium FG9065 disodium	iGluR	Neurological Disease
CNQX disodium (FG9065 disodium) is a potent and competitive AMPA/kainate receptor antagonist with IC₅₀s of 0.3 μM and 1.5 μM, respectively. CNQX disodium is a competitive non-NMDA receptor antagonist. CNQX disodium blocks the expression of fear-potentiated startle in rats.

HY-A0021C

(R,R)-Palonosetron Hydrochloride
5-HT Receptor Inflammation/Immunology

(R,R)-Palonosetron Hydrochloride is the active enantiomer of Palonosetron.

*(R,R)-Palonosetron Hydrochloride*	5-HT Receptor	Inflammation/Immunology
(R,R)-Palonosetron Hydrochloride is the active enantiomer of Palonosetron.

HY-15187A

(R)-Filanesib (R)-ARRY-520	Kinesin	Cancer
(R)-Filanesib ((R)-ARRY-520) is the R-enantiomer of ARRY-520. (R)-Filanesib ((R)-ARRY-520) is a synthetic kinesin spindle protein (KSP) inhibitor with IC₅₀ of 6 nM.

HY-102091

(2R,4R)-APDC	mGluR	Neurological Disease
(2R,4R)-APDC is a selective group II metabotropic glutamate receptors (mGluRs) agonist. (2R,4R)-APDC has anticonvulsant and neuroprotective effects.

HY-78131B

(R)-(-)-Ibuprofen (R)-Ibuprofen	NF-κB	Inflammation/Immunology Cancer
(R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects.

HY-B0352B

(R)-Mirtazapine (R)-Org3770; (R)-6-Azamianserin	5-HT Receptor	Neurological Disease
(R)-Mirtazapine ((R)-Org3770) is a R(−)-enantiomer of Mirtazapine with antinociceptive properties in an animal model of acute thermal nociception. (R)-Mirtazapine is a 5-HT₃ receptor antagonist. (R)-Mirtazapine is mainly metabolized by CYP3A4.

HY-B0006C

(R)-Carvedilol (R)-BM 14190	Adrenergic Receptor	Cardiovascular Disease
(R)-Carvedilol ((R)-BM 14190), the R-enantiomer of Carvedilol, is a non-selective β/α-1 blocker. (R)-Carvedilol exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX).

HY-109854A

(R)-Lisofylline (R)-Lisophylline	STAT	Metabolic Disease Inflammation/Immunology
(R)-Lisofylline ((R)-Lisophylline) is a (R)-enantiomer of the metabolite of Pentoxifylline with anti-inflammatory properties. (R)-Lisofylline is a lysophosphatidic acid acyltransferase inhibitor with an IC₅₀ of 0.6 µM and interrupts IL-12 signaling-mediated STAT4 activation. (R)-Lisofylline has the potential for type 1 diabetes, autoimmune disorders research.

HY-100615A

R 80123
Phosphodiesterase (PDE) Cardiovascular Disease

R 80123 is the Z-isomer of R 79595, is also a highly selective phosphodiesterase inhibitor.

R 80123	Phosphodiesterase (PDE)	Cardiovascular Disease
R 80123 is the Z-isomer of R 79595, is also a highly selective phosphodiesterase inhibitor.

HY-10013B

Taranabant ((1R,2R)stereoisomer) MK0364 (1R,2R)stereoisomer	Cannabinoid Receptor	Others
Taranabant (1R,2R)stereoisomer is the R-enantiomer of Taranabant. Taranabant is a highly potent and selective cannabinoid 1 (CB1) receptor inverse agonist.

HY-116463A

(2R,3S)-E1R	Sigma Receptor	Neurological Disease
(2R,3S)-E1R (Compound 2c) is an enantiomer of E1R. (2R,3S)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders.

HY-108497

L-803087	Somatostatin Receptor	Cancer Neurological Disease
L-803087 is a potent and selective somatostatin sst4 receptor agonist with a K_i of 0.7 nM. L-803087 is >280-fold higher than other somatostatin receptors. L-803087 facilitates AMPA-mediated hippocampal synaptic responses in vitro and increases kainate-induced seizures in mice.

HY-15781A

Morinidazole (R enantiomer) R-Morinidazole	Bacterial	Infection
Morinidazole R enantiomer is the R-enantiomer of Morinidazole. Morinidazole is a new 5-nitroimidazole class antimicrobial agent. Morinidazole R enantiomer is the less active enantiomer.

HY-135406

(3R,5R)-Rosuvastatin Lactone
Others Cardiovascular Disease Metabolic Disease

(3R,5R)-Rosuvastatin Lactone is an isomer of Rosuvastatin Lactone.
HY-101570A

(R)-Nedisertib
(R)-M3814
DNA-PK Cancer

(R)-Nedisertib ((R)-M3814) is a less active R-enantiomer of Nedisertib, with an IC₅₀ in the range of 7-30 nM for DNA-PK.
HY-I0636

(R)-Apremilast
(R)-CC-10004
Others Inflammation/Immunology

(R)-Apremilast ((R)-CC-10004) is a enantiomer of Apremilast.
HY-101474B

(R)-Zanubrutinib
(R)-BGB-3111
Others Others

(R)-Zanubrutinib is the R enantiomer of Zanubrutinib. Zanubrutinib is a selective Bruton tyrosine kinase (BTK) inhibitor.

(3R,5R)-Rosuvastatin Lactone	Others	Cardiovascular Disease Metabolic Disease
(3R,5R)-Rosuvastatin Lactone is an isomer of Rosuvastatin Lactone.

(R)-Nedisertib (R)-M3814	DNA-PK	Cancer
(R)-Nedisertib ((R)-M3814) is a less active R-enantiomer of Nedisertib, with an IC₅₀ in the range of 7-30 nM for DNA-PK.

(R)-Apremilast (R)-CC-10004	Others	Inflammation/Immunology
(R)-Apremilast ((R)-CC-10004) is a enantiomer of Apremilast.

(R)-Zanubrutinib (R)-BGB-3111	Others	Others
(R)-Zanubrutinib is the R enantiomer of Zanubrutinib. Zanubrutinib is a selective Bruton tyrosine kinase (BTK) inhibitor.

HY-13728A

(R)-Plevitrexed (R)-ZD 9331; (R)-BGC9331	Others	Cancer
(R)-Plevitrexed ((R)-ZD 9331; (R)-BGC9331) is a less active enantiomer of Plevitrexed. Plevitrexed is an orally active and potent thymidylate synthase (TS) inhibitor.

HY-106841

Draflazine R-75231; R88021	Others	Inflammation/Immunology
Draflazine (R-75231) is a ENT1 inhibitor. Draflazine (R-75231) completely reverses the hypersensitivity in the complete Freund’s adjuvant (CFA) model of mechanical hyperalgesia and the carrageenan inflammation model of thermal and mechanical hyperalgesia.

HY-17554

(R)-Oxiracetam (R)-(+)-Oxiracetam	Others	Neurological Disease
(R)-Oxiracetam is the (R)-enantiomer of the nootropic drug oxiracetam. Oxiracetam (ISF 2522) is a nootropic drug of the racetam family and stimulant.

HY-112172

Tenalisib R Enantiomer
RP6530 R Enantiomer
Others Cancer

Tenalisib R Enantiomer is an R enantiomer of Tenalisib.

Tenalisib R Enantiomer RP6530 R Enantiomer	Others	Cancer
Tenalisib R Enantiomer is an R enantiomer of Tenalisib.

HY-78846

2R,4R-Sacubitril	Others	Cardiovascular Disease
2R,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and Drug Administration for use in combination with valsartan for the treatment of patients with heart failure.

HY-108497A

L-803087 TFA	Somatostatin Receptor	Cancer Neurological Disease
L-803087 TFA is a potent and selective somatostatin sst4 receptor agonist with a K_i of 0.7 nM. L-803087 TFA is >280-fold more selective for sst4 receptor than other somatostatin receptors. L-803087 TFA facilitates AMPA-mediated hippocampal synaptic responses in vitro and increases kainate-induced seizures in mice.

HY-10809A

Bitopertin R enantiomer RG1678 (R enantiomer); RO4917838 (R enantiomer)	GlyT	Neurological Disease
Bitopertin R enantiomer (RG1678 R enantiomer; RO4917838 R enantiomer) is the R-enantiomer of Bitopertin. Bitopertin is a potent, noncompetitive glycine reuptake inhibitor, inhibits glycine uptake at human GlyT1 with a concentration exhibiting IC50 of 25 nM.

HY-B0105B

(-)-Ketoconazole (-)-Ketoconazol; (-)-R 41400	Fungal	Infection Inflammation/Immunology
(-)-Ketoconazole ((-)-R 41400) is one of the enantiomer of Ketoconazole. Ketoconazole is a racemic mixture of two enantiomers, levoketoconazole ((2S,4R)-(−)-ketoconazole) and dextroketoconazole ((2R,4S)-(+)-ketoconazole).

HY-108263B

(R)-3-Hydroxy Midostaurin (R)-CGP52421	FLT3 Drug Metabolite	Cancer
(R)-3-Hydroxy Midostaurin ((R)-CGP52421) is a potent kinases inhibitor. (R)-3-Hydroxy Midostaurin is a major metabolite of midostaurin (PKC412; HY-10230) undergoing by the hepatic CYP3A4 enzyme. (R)-3-Hydroxy Midostaurin has the potential for acute myeloid leukemia (AML).

HY-B2111

(R)-(+)-Atenolol
Adrenergic Receptor Others

(R)-(+)-Atenolol is the less active enantiomer of the (R,S)-atenolol. (R,S)-atenolol is a β-adrenergic receptor antagonist.
HY-19939S2

(R)-VX-984
(R)-M9831
Others Others

(R)-VX-984 ((R)-M9831) is the (R)-enantiomer of VX-984. VX-984 is a potent DNA-PK inhibitor.
HY-N2049

20(R)-Notoginsenoside R2
Others Neurological Disease

20(R)-Notoginsenoside R2 is an isolated notoginsenoside from Panax notoginseng.

(R)-(+)-Atenolol	Adrenergic Receptor	Others
(R)-(+)-Atenolol is the less active enantiomer of the (R,S)-atenolol. (R,S)-atenolol is a β-adrenergic receptor antagonist.

(R)-VX-984 (R)-M9831	Others	Others
(R)-VX-984 ((R)-M9831) is the (R)-enantiomer of VX-984. VX-984 is a potent DNA-PK inhibitor.

20(R)-Notoginsenoside R2	Others	Neurological Disease
20(R)-Notoginsenoside R2 is an isolated notoginsenoside from Panax notoginseng.

HY-B0612D

(R)-Lercanidipine hydrochloride	Calcium Channel	Cardiovascular Disease
(R)-Lercanidipine hydrochloride is the R-enantiomer of Lercanidipine. (R)-lercanidipine hydrochloride is a calcium channel blocker.

HY-17504C

(3R,5R)-Rosuvastatin	HMG-CoA Reductase (HMGCR) Potassium Channel Autophagy	Metabolic Disease Cardiovascular Disease
(3R,5R)-Rosuvastatin is the (3R,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor with an IC₅₀ of 11 nM. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC₅₀ of 195 nM. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin is very effective in lowering low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels.

HY-P9803

Anti-SARS-80R mAb SARS-80R; SARS Antibody-80R	SARS-CoV	Infection
Anti-SARS-80R mAb (SARS-80R) is a human monoclonal IgG1 antibody produced in CHO cells. Anti-SARS-80R mAb can specifically bind to Spike (S1) protein to prevent SARS virus infection of susceptible cells.

HY-100888A

(R)-Simurosertib (R)-TAK-931	Others	Others
(R)-Simurosertib ((R)-TAK-931) is the (R)-enantiomer of Simurosertib. Simurosertib (TAK-931) is an orally active, selective and ATP-competitive cell division cycle 7 (CDC7) kinase inhibitor, with an IC₅₀ of <0.3 nM .

HY-15452B

Selisistat R-enantiomer EX-527 (R-enantiomer)	Sirtuin	Cancer
Selisistat R-enantiomer (EX-527 R-enantiomer) is much less active R-enantiomer of Selisistat, with an IC₅₀ of > 100 μM for SIRT1.

HY-12953

R-268712
TGF-β Receptor Cancer

R-268712 is a potent and selective inhibitor of ALK5 with an IC50 of 2.5 nM.

R-268712	TGF-β Receptor	Cancer
R-268712 is a potent and selective inhibitor of ALK5 with an IC50 of 2.5 nM.

HY-19432

UBP-282	iGluR	Neurological Disease
UBP-282 is a potent, selective and competitive *AMPA* and kainate receptor antagonist. UBP-282 inhibits the fast component of the dorsal root-evoked ventral root potential (fDR-VRP) with an IC₅₀ value of 10.3 μM. UBP-282 antagonizes kainate-induced depolarisations of dorsal roots with a pA₂ value of 4.96.

HY-13079

Cobimetinib R-enantiomer GDC-0973 R-enantiomer; XL-518 R-enantiomer	MEK	Cancer
Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib. Cobimetinib is a potent and selective MEK inhibitor.

HY-100013A1

(1R,2R)-2-PCCA(hydrochloride)	Others	Neurological Disease
(1R,2R)-2-PCCA hydrochloride is a diastereomer of 2-PCCA, and acts as a potent GPR88 receptor agonist, with an EC₅₀ of 3 nM in cell-free assay, and 603 nM in cell assay.

HY-13636B

Fulvestrant (R enantiomer) ICI 182780 (R enantiomer); ZD 9238 (R enantiomer); ZM 182780 (R enantiomer)	Others	Cancer
Fulvestrant R enantiomer (ICI 182780 R enantiomer; ZD 9238 R enantiomer; ZM 182780 R enantiomer) is the less active R enantiomer of Fulvestrant. Fulvestrant is a potent estrogen receptor antagonist with an IC₅₀ of 9.4 nM.

HY-B0352BS

(R)-Mirtazapine D3 (R)-Org3770 D3; (R)-6-Azamianserin D3	5-HT Receptor	Neurological Disease
(R)-Mirtazapine D3 ((R)-Org3770 D3) is a deuterium labeled (R)-Mirtazapine. (R)-Mirtazapine is a R(−)-enantiomer of Mirtazapine with antinociceptive properties in an animal model of acute thermal nociception. (R)-Mirtazapine is a 5-HT₃ receptor antagonist. (R)-Mirtazapine is mainly metabolized by CYP3A4.

HY-W015954

(2R,3R)-Butane-2,3-diol
Endogenous Metabolite Metabolic Disease

(2R,3R)-Butane-2,3-diol is an endogenous metabolite.

HY-15996A

Seviteronel R enantiomer VT-464 (R enantiomer)	Others	Cancer
Seviteronel R enantiomer (VT-464 R enantiomer) is the R enantiomer of Seviteronel (VT-464), which is a potent CYP17 lyase inhibitor(h-Lyase IC50=69 nM); Seviteronel (VT-464) R enantiomer's activity is unknown.

HY-16420

R112
Syk Inflammation/Immunology

R112 is an ATP-competitive inhibitor of Syk kinase with a Ki of 96 nM. R112 inhibits Syk kinase activity with an IC50 of 226 nM.

HY-135336

(R)-Verapamil hydrochloride (R)-(+)-Verapamil hydrochloride	P-glycoprotein Apoptosis	Cancer
(R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is a P-Glycoprotein inhibitor. (R)-Verapamil hydrochloride blocks MRP1 mediated transport, resulting in chemosensitization of MRP1-overexpressing cells to anticancer drugs.

HY-B0105

Ketoconazole
Ketoconazol; R 41400
Fungal Cytochrome P450 Infection Cancer

Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.

HY-18658A

Siremadlin R Enantiomer NVP-HDM201 R Enantiomer; HDM201 R Enantiomer	Others	Others
Siremadlin R Enantiomer (NVP-HDM201 R Enantiomer) is the R enantiomer of Siremadlin. Siremadlin is a potent and highly specific MDM-2/p53 inhibitor.

HY-104075

R916562	TAM Receptor VEGFR	Cancer
R916562 is an orally active and selective *Axl/VEGF-R2* inhibitor with IC₅₀s of 136 nM and 24 nM, respectively. R916562 has anti-angiogenesis and anti-metastasis.

HY-B0357

Diclazuril
R-64433
Parasite Antibiotic Infection

Diclazuril (R-64433) is an anti-coccidial drug.

HY-B1675

Levalbuterol (R)-Albuterol; (R)-Salbutamol; Levosalbutamol	Adrenergic Receptor	Inflammation/Immunology
Levalbuterol ((R)-Albuterol; (R)-Salbutamol) is a short-acting β2-adrenergic receptor agonist and the active (R)-enantiomer of Salbutamol. Levalbuterol is a more potent bronchodilator than Salbutamol and has the potential for the treatment of COPD.

HY-B0580B

(R)-Ketorolac (+)-Ketorolac	Others	Neurological Disease
(R)-Ketorolac is the R-enantiomer of Ketorolac, shows potent analgesic activity, reduces ulcerogenic potential. (R)-Ketorolac is inactive on COX.

HY-15481

KU14R
Insulin Receptor Metabolic Disease Endocrinology

KU14R is a new I(3)-R antagonist, which selectively blocks the insulin secretory response to imidazolines.
HY-19988

THZ1-R
CDK Cancer

THZ1-R is a non-cysteine reactive analog of THZ1 which displays diminished activity for CDK7 inhibition. THZ1-R binds to CDK7 with a K_d of 142 nM.

HY-116463D

(Rac)-E1R	Sigma Receptor	Neurological Disease
(Rac)-E1R (Compound 2) is the racemate of E1R. (Rac)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders.

HY-12279F

Umbralisib R-enantiomer TGR-1202 R-enantiomer; RP5264 R-enantiomer	PI3K	Cancer
Umbralisib R-enantiomer (TGR-1202 R-enantiomer) is a PI3Kδ inhibitor, which is the less active enantiomer of TGR-1202.

HY-16900A

(R)-(-)-Rolipram (R)-Rolipram; (-)-Rolipram	Phosphodiesterase (PDE)	Neurological Disease
(R)-(-)-Rolipram is the R-enantiomer of Rolipram. Rolipram is a selective inhibitor of phosphodiesterases PDE4 with IC₅₀ of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.

HY-75087

(R)-pyrrolidine-2-carboxylic acid (+)-(R)-Proline; (R)-(+)-Proline; (R)-2-Carboxypyrrolidine; (R)-Proline	Endogenous Metabolite	Metabolic Disease
(R)-pyrrolidine-2-carboxylic acid is an endogenous metabolite.

HY-135336S

(R)-Verapamil D7 hydrochloride (R)-(+)-Verapamil D7 hydrochloride	P-glycoprotein Apoptosis	Cancer
(R)-Verapamil D7 hydrochloride ((R)-(+)-Verapamil D7 hydrochloride) is a deuterium labeled (R)-Verapamil hydrochloride. (R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is a P-Glycoprotein inhibitor. (R)-Verapamil hydrochloride blocks MRP1 mediated transport, resulting in chemosensitization of MRP1-overexpressing cells to anticancer drugs.

HY-122219

R243	CCR	Inflammation/Immunology
R243 is a potent and selective CCR8 antagonist. R243 inhibits CCL₁/CCR8 interaction and inhibits CCR8 signaling and chemotaxis. R243 has antinociceptive and anti-inflammatory effects.

HY-18767A

(R,S)-Ivosidenib
(R,S)-AG-120
Isocitrate Dehydrogenase (IDH) Cancer

(R,S)-Ivosidenib ((R,S)-AG-120) is the less active enantiomer of Ivosidenib (AG-120).

HY-110234

Topiramate D12 McN 4853 D12 ; RWJ 17021 D12	iGluR GABA Receptor Sodium Channel Calcium Channel Potassium Channel Carbonic Anhydrase	Neurological Disease
Topiramate D12 (McN 4853 D12) is a deuterium labeled Topiramate. Topiramate is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of *kainate/AMPA* receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase.

HY-122751

(R)-DNMDP	Phosphodiesterase (PDE)	Cancer
(R)-DNMDP is a potent and selective cancer cell cytotoxic agent. (R)-DNMDP, the R-form of DNMDP, binds PDE3A directly. DNMDP binding to PDE3A promotes an interaction between PDE3A and Schlafen 12 (SLFN12).

HY-101281B

(R)-VU 6008667
Others Neurological Disease

(R)-VU 6008667, the less active (R)-enantiomer to VU 6008667, is devoid of M5 NAM activity (IC₅₀>10 μM).
HY-101183A

THK5351 R enantiomer
Others Neurological Disease

THK5351 R enantiomer is an R enantiomer of THK5351.

HY-15793A

Trans (2,3)-Dihydrotetrabenazine (2R,3R,11bR)-rel-Dihydrotetrabenazine; (2R,3R,11bR)-rel-DHTBZ	Drug Metabolite Monoamine Transporter	Neurological Disease
Trans (2,3)-Dihydrotetrabenazine ((2R,3R,11bR)-rel-Dihydrotetrabenazine), a metabolite of Tetrabenazine, shows remarkable inhibition activity on vesicular monoamine transporter (VMAT2).

HY-13038A

Fostamatinib
R788
Syk Inflammation/Immunology Cancer

Fostamatinib (R788), a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM.

HY-B0371B

(R)-Terazosin	Adrenergic Receptor	Endocrinology
(R)-Terazosin is an active R-enantiomer of Terazosin. (R)-Terazosin is a potent α1-adrenoceptor antagonist with K_i values of 6.51 nM, 1.01 nM and 1.97 nM for α1a, α1b and α1d-adrenoceptor, respectively.

HY-12693

R(+)-IAA-94
R(+)-Methylindazone
Chloride Channel Others

R(+)-IAA-94 is a potent indanyloxyacetic acid blocker of epithelial chloride channels.

HY-B0612DS

(R)-Lercanidipine D3 hydrochloride	Calcium Channel	Cardiovascular Disease
(R)-lercanidipine D3 (hydrochloride) is a deuterium labeled (R)-Lercanidipine hydrochloride. (R)-Lercanidipine D3 (hydrochloride), the R-enantiomer of Lercanidipine, is a calcium channel blocker.

HY-111532

(3R,4R)-A2-32-01	Bacterial	Infection
(3R,4R)-A2-32-01 (compound 2), an anti-virulence drug, is a specific caseinolytic protein proteases (ClpP) inhibitor with an EC₅₀ of 4.5 μM, and shows a tolerable cytotoxicity.

HY-10619D

Niraparib (R-enantiomer)
MK 4827 (R-enantiomer)
PARP Cancer

Niraparib R-enantiomer (MK-4827 R-enantiomer) is an excellent PARP1 inhibitor with IC₅₀ of 2.4 nM.

HY-12993B

RSV604 R enantiomer	RSV	Infection
RSV604 R enantiomer is the R-enantiomer of RSV604. RSV604 is an inhibitor of respiratory syncytial virus (RSV) replication. R-enantiomer is less active against RSV.

HY-124257

(R)-Citronellol D-Citronellol; (R)-(+)-β-Citronellol	Endogenous Metabolite	Inflammation/Immunology
(R)-Citronellol (D-Citronellol) is an alcoholic monoterpene found in geranium essential oil. (R)-Citronellol inhibits degranulation of mast cells and does not affect caffeine bitterness perception. (R)-Citronellol can be used in decorative cosmetics, toiletries as well as in non-cosmetic products.

HY-126057S

(R)-Praziquantel D11	Parasite 5-HT Receptor	Infection
(R)-Praziquantel D11 is the deuterium labeled (R)-Praziquantel. (R)-Praziquantel, the active enantiomer of Praziquantel, is a partial agonist of the human 5-HT2B receptor. (R)-Praziquantel acts as an antischistosomal eutomer.

HY-N2207

rel-(8R,8'R)-Dimethyl-(7S,7'R)-bis(3,4-methylenedioxyphenyl)tetrahydro-furan	Others	Others
rel-(8R,8'R)-Dimethyl-(7S,7'R)-bis(3,4-methylenedioxyphenyl)tetrahydro-furan is a chemical constituent of the fruit of Myristica fragrans.

HY-12515C

(R)-Nicardipine (R)-YC-93 free base	Others	Neurological Disease Cardiovascular Disease
(R)-Nicardipine ((R)-YC-93 free base) is the less active R enantiomer of Nicardipine. Nicardipine (YC-93) is a calcium channel blocker with an IC₅₀ of 1 μM for blocking cardiac calcium channels. Nicardipine acts as an agent for chronic stable angina and for controlling blood pressure.

HY-B0526

Flumequine R-802	Bacterial Topoisomerase Antibiotic	Infection Cancer
Flumequine (R-802) is a quinolone antibiotic, and acts as a topoisomerase II inhibitor, with an IC₅₀ of 15 μM (3.92 μg/mL).

HY-16106A

(8R,9S)-Talazoparib (8R,9S)-BMN-673; (8R,9S)-LT-673	PARP	Cancer
(8R,9S)-Talazoparib ((8R,9S)-BMN-673) is an enantiomer of Talazoparib, less active than Talazoparib on the inhibition of PARP1, with an IC₅₀ of 144 nM.

HY-120097

R-10015	LIM Kinase (LIMK) Reverse Transcriptase	Infection
R-10015, a broad-spectrum antiviral compound for HIV infection, acts as a potent and selective inhibitor of LIM domain kinase (LIMK) and binds to the ATP-binding pocket, with an IC₅₀ of 38 nM for human LIMK1.

HY-13737

R1530
VEGFR Apoptosis Cancer

R1530 is the multikinase inhibitor with potential antiangiogenesis and antineoplastic activities.

HY-12305A

(R)-Q-VD-OPh (R)-QVD-OPH; (R)-Quinoline-Val-Asp-Difluorophenoxymethylketone	Others	Cancer
(R)-Q-VD-OPh ((R)-QVD-OPH) is the less active enantiomer of Q-VD-OPha. Q-VD-OPha is an irreversible pan-caspase inhibitor with potent antiapoptotic properties.

HY-77490

(R)-(-)-1,3-Butanediol
Endogenous Metabolite Metabolic Disease

(R)-(-)-1,3-Butanediol is used to regulate the metabolism of carbohydrate and lipid.
HY-B0180

Imiquimod
R 837
Toll-like Receptor (TLR) Autophagy HSV Inflammation/Immunology Cancer

Imiquimod (R 837) is an immune response modifier that acts as a toll-like receptor 7 agonist.

HY-10444

R-1479 4'-Azidocytidine	HCV DNA/RNA Synthesis	Infection
R-1479 (4'-Azidocytidine), a nucleoside analogue, is a specific inhibitor of RNA-dependent RNA polymerase (RdRp) of HCV. R-1479 inhibits HCV replication in the HCV subgenomic replicon system (IC₅₀=1.28 μM).

HY-N6679

(R)-10,11-Dehydrocurvularin	Others	Cancer
(R)-10,11-Dehydrocurvularin is a secondary metabolite isolated from Curvularia sp.. (R)-10,11-Dehydrocurvularin displays concentration-dependent cytotoxicity towards human tumor cell lines with a mean IC₅₀ value of 1.25 µM.

HY-116463

E1R
Sigma Receptor Neurological Disease

E1R is a positive allosteric modulator of sigma-1 receptors (Sig1R PAM) with cognition-enhancing activity.
HY-18102A

GLPG0492 R enantiomer
Androgen Receptor Neurological Disease

GLPG0492 R enantiomer is the R enantiomer of GLPG-0492, which is a novel selective androgen receptor modulator.

HY-18733

Lipoic acid (R)-(+)-α-Lipoic acid; R-(+)-Thioctic acid	Mitochondrial Metabolism Endogenous Metabolite Reactive Oxygen Species	Inflammation/Immunology Cancer
Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.

HY-19322C

(1S,3R,5R)-PIM447 dihydrochloride (1S,3R,5R)-LGH447 dihydrochloride	Pim	Cancer
(1S,3R,5R)-PIM447 (dihydrochloride) an PIM inhibitor extracted from patent US 20100056576 A1, compound example 72, has IC₅₀ values of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3.

HY-N1376

20(R)-Ginsenoside Rg3 20(R)-Propanaxadiol; R-ginsenoside Rg3	Others	Cancer
20(R)-ginsenoside Rg3 (20(R)-Propanaxadiol), one of the active compounds present in ginseng root, has a potent angiosuppressive and antitumor activities.

HY-34516

(R)-Ornithine hydrochloride
Endogenous Metabolite Metabolic Disease

(R)-Ornithine hydrochloride is an endogenous metabolite.
HY-15677A

INT-777 R-enantiomer
S-EMCA R enantiomer
GPCR19 Others

INT-777 (R-enantiomer) is the R-enantiomer of INT-777, with EC₅₀ of 4.79 μM for TGR5, and less potent than INT-777.

HY-15355

Loviride R 89439	Reverse Transcriptase HIV	Infection
Loviride (R 89439) is a non-nucleoside reverse transcriptase inhibitor (NNRTI), with an IC₅₀ of 0.3 µM for reverse transcriptase from HIV-1. Loviride (R 89439) inhibits HIV-1, HIV-2 and SIV replication in MT-4 cells.

HY-P2282

APTSTAT3-9R	STAT	Cancer
APTSTAT3-9R, a specific STAT3-binding peptide, inhibits STAT3 activation and downstream signaling by specifically blocking STAT3 phosphorylation. APTSTAT3-9R exerts antiproliferative effects and antitumor activity.

HY-19488B

Ribocil-C (R enantiomer)
Bacterial Infection

Ribocil-C R enantiomer is the R enantiomer of Ribocil-C. Ribocil-C is a highly selective inhibitor of bacterial riboflavin riboswitches.
HY-B0105A

(+)-Ketoconazole
(+)-Ketoconazol; (+)-R 41400
Fungal Cytochrome P450 Infection

(+)-Ketoconazole ((+)-R 41400) is an imidazole anti-fungal agent, a CYP3A4 inhibitor.
HY-50674A

INCB3344 R-isomer
Others Inflammation/Immunology

INCB3344 R-isomer is the R-isomer of INCB3344. INCB3344 is a potent CCR2 antagonist.
HY-W051723

(R)-3-Hydroxybutanoic acid
Endogenous Metabolite Others

(R)-3-Hydroxybutanoic acid is a metabolite, and converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase.
HY-111095B

(2R)-2-Hydroxypropanoate sodium
Endogenous Metabolite Metabolic Disease

(2R)-2-Hydroxypropanoate sodium is an endogenous metabolite.
HY-103016

WZ4141R
Others Others

WZ4141R is an intermediate in the synthesis of compounds.

HY-129079

TFMB-(R)-2-HG	Others	Cancer
TFMB-(R)-2-HG, a cell membrane-permeable version of (R)-2-HG, is a carcinogenic factor in Acute myeloid leukemia (AML). TFMB-(R)-2-HG impairs SCF ER-Hoxb8 cells differentiation in response to estrogen withdrawal.

HY-17044A

Duvelisib R enantiomer
IPI-145 R enantiomer; INK1197 R enantiomer
PI3K Cancer

Duvelisib R enantiomer is a PI3K inhibitor, which is the less active enantiomer of Duvelisib.

HY-126050

(R)-Pantetheine Pantetheine	Others	Metabolic Disease
(R)-Pantetheine is the biosynthetic precursor to CoA. (R)-Pantetheine and its corresponding disulfide pantethine, play a key role in metabolism as a building block of coenzyme A (CoA).

HY-101405

Gestrinone R 2323	Estrogen Receptor/ERR	Inflammation/Immunology
Gestrinone (R2323) is a synthetic steroid hormone used to treat endometriosis. It inhibits leiomyoma cells with an IC₅₀ of 43.67 μM.

HY-W014410

(2R,3S,4R,5S)-2,3,4,5-Tetrahydroxyhexanedioic acid
Endogenous Metabolite Metabolic Disease

(2R,3S,4R,5S)-2,3,4,5-Tetrahydroxyhexanedioic acid is an endogenous metabolite.

HY-13755A

(R)-Sulforaphane	Others	Cancer
(R)-Sulforaphane is a highly potent inducer of the Keap1/Nrf2/ARE pathway. (R)-Sulforaphane is a far more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer.

HY-103234A

GYKI 52466 dihydrochloride	iGluR	Neurological Disease
GYKI 52466 dihydrochloride is a potent, selective, orally active and non-competitive *kainate- and AMPA-activated currents* antagonist with IC₅₀s of 7.5 μM and 11 μM, respectively. GYKI 52466 dihydrochloride is inactive against N-methyl-D-aspartate (NMDA) or γ-aminobutyric acid responses. GYKI 52466 dihydrochloride ia a muscle relaxant and anticonvulsant agent, and has good blood brain barrier permeability.

HY-124373A

(R)-ND-336	MMP	Metabolic Disease
(R)-ND-336 is a potent and selective MMP-9 inhibitor with a K_i of 19 nM. (R)-ND-336 inhibits MMP-2 (K_i=127 nM) and MMP-14 (K_i=119 nM). (R)-ND-336 has the potential for diabetic foot ulcers (DFUs) research.

HY-108900A

Leu-AMS R enantiomer	Aminoacyl-tRNA Synthetase	Others
Leu-AMS R enantiomer is the R enatiomer of Leu-AMS. Leu-AMS is a potent inhibitor of leucyl-tRNA synthetase (LRS) and inhibits the growth of bacteria.

HY-11017AS

(R)-Rivastigmine D6 tartrate
AChE Neurological Disease

(R)-Rivastigmine D6 (tartrate) is the deuterium labeled (R)-Rivastigmine, which is an cholinesterase inhibitor.
HY-15193A

EMD638683 R-Form
SGK Metabolic Disease

EMD638683 R-Form is the R-form of EMD638683. EMD638683 is a highly selective SGK1 inhibitor with IC₅₀ of 3 μM.

HY-10291

Tarenflurbil (R)-Flurbiprofen; MPC7869	RAR/RXR Autophagy	Inflammation/Immunology Neurological Disease
Tarenflurbil ((R)-Flurbiprofen) is the R-enantiomer of the racemate NSAID Flurbiprofen, Tarenflurbil ((R)-Flurbiprofen) inhibits the binding of [³H]9-cis-RA to RXRα LBD with IC₅₀ of 75 μM.

HY-101445A

(R)-Trolox	Tyrosinase	Cancer
(R)-Trolox is a water soluble vitamin E analogue and a competitive tyrosinase inhibitor with a K_i value of 0.83 mM and a ID₅₀ value of 1.88 mM. The (R)-Trolox has stronger tyrosinase affinity than the (S) enantiomer (K_i value of 0.61 mM).

HY-B0100

Etomidate R 16659	GABA Receptor	Neurological Disease
Etomidate(R-16659) is a GABAA receptors agonist, which is a short acting intravenous anaesthetic agent used for the induction of general anaesthesia.

HY-17355A

Dexpramipexole dihydrochloride (R)-Pramipexole dihydrochloride; R-(+)-Pramipexole dihydrochloride; KNS-760704 dihydrochloride	Dopamine Receptor	Neurological Disease
Dexpramipexole dihydrochloride ((R)-Pramipexole dihydrochloride) is a neuroprotective agent and weak non-ergoline dopamine agonist.

HY-14149

Cisapride
(±)-Cisaprid; R 51619
5-HT Receptor Neurological Disease

Cisapride(R 51619) is a nonselective 5-HT4 receptor agonist, it is also a potent hERG potassium channel inhibitor.
HY-18675

IQ-R
Others Others

IQ-R is a novel hypoxia-sensitive fluorescent probe, consisting of an indolequinone unit and a rhodol fluorophore.

HY-111501

H4R antagonist 1	Histamine Receptor	Inflammation/Immunology Endocrinology
H4R antagonist 1 is a potent and highly selective histamine H4 receptor (H4R) antagonist with an IC₅₀ of 27 nM. H4R antagonist 1 does not show any noticeable binding affinity to other subtypes of histamine receptors, H1R, H2R, and H3R.

HY-B0590B

(+)-Tetrabenazine (+)-TBZ; (3R,11bR)-TBZ; (3R,11bR)-Tetrabenazine	Monoamine Transporter	Cancer
(+)-Tetrabenazine ((+)-TBZ; (3R,11bR)-TBZ; (3R,11bR)-Tetrabenazine) is a reversible inhibitor of vesicular monoamine transporter 2 (VMAT-2), inhibits transport by VMAT2 with 10-fold greater potency than transport by VMAT1.

HY-112164A

IACS-8968 R-enantiomer IDO/TDO Inhibitor (R-enantiomer)	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IACS-8968 (R-enantiomer) is the R-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor, with pIC₅₀s of 6.43 for IDO and <5 for TDO, respectively.

HY-101774

CSF1R-IN-1
c-Fms Cancer

CSF1R-IN-1 is a CSF1R inhibitor with an with an IC₅₀ of 0.5 nM.

HY-107985A

(R)-FT671	Others	Others
(R)-FT671 is the R-isomer of FT671. FT671 is a potent, non-covalent and selective USP7 inhibitor with an IC₅₀ of 52 nM and binds to the USP7 catalytic domain with a K_d of 65 nM.

HY-N0615

Notoginsenoside R1 Sanchinoside R1; Sanqi glucoside R1	Amyloid-β	Others
Notoginsenoside R1, the main bioactive component in panaxnotoginseng, is reported to have some neuronal protective, antihypertensive effects.

HY-103641

(2R)-Octyl-α-hydroxyglutarate
(2R)-Octyl-2-HG
Others Cancer

(2R)-Octyl-α-hydroxyglutarate ((2R)-Octyl-2-HG) is a modified form of D-isomer 2-Hydroxyglutarate.
HY-15125

(R)-(+)-Bay-K-8644
Calcium Channel Cardiovascular Disease

(R)-(+)-Bay-K-8644 is a calcium channel inhibitor. (R)-(+)-Bay-K-8644 inhibits Ba²⁺ currents (I_Ba) (IC₅₀=975 nM).

HY-U00396

MC-4R Agonist 1	Melanocortin Receptor	Metabolic Disease Endocrinology
MC-4R Agonist 1 is an agonist of human melanocortin-4 receptor (MC-4R), used in the research of obesity, diabetes, and sexual dysfunction.

HY-13456

LY-404187	iGluR	Neurological Disease
LY-404187 is a potent, selective and centrally active positive allosteric modulator of AMPA receptors, with the EC₅₀s of 5.65, 0.15, 1.44, 1.66 and 0.21 µM for GluR1i, GluR2i, GluR2o, GluR3i and GluR4i, respectively. LY-404187 has therapeutic potential in a number of psychiatric disorders and neurodegenerative diseases.

HY-14975

R1487 Hydrochloride
p38 MAPK Autophagy Cancer

R1487 (Hydrochloride) is highly potent and highly selective inhibitors of p38α.

HY-13038

Fostamatinib Disodium R788(Disodium)	Syk	Inflammation/Immunology Cancer
Fostamatinib Disodium (R788 Disodium), a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM.

HY-P1404

R8-T198wt	Pim
R8-T198wt is a cell-permeable peptide inhibitor of Pim-1 kinase, derived from p27Kip1. R8-T198wt inhibits Pim-1 phosphorylation of p27Kip1 and Bad; induces cell cycle arrest (at G1) and apoptosis in DU145 prostate cancer cells. R8-T198wt also inhibits Pim-1-dependent growth of DU145 cells in vitro and in vivo. R8-T198wt displays no effect on the growth of normal prostate epithelial RPWE-1 cells at concentrations of 10 and 20 μM.

HY-B1470

Azaperone R-1929	Dopamine Receptor	Neurological Disease
Azaperone (R-1929) acts as a dopamine antagonist but also has some antihistaminic and anticholinergic properties. Azaperone is a pyridinylpiperazine and butyrophenone neuroleptic drug with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine.

HY-100742A

(R)-GNE-140	Lactate Dehydrogenase	Cancer
(R)-GNE-140 is a potent lactate dehydrogenase A (LDHA) inhibitor, with IC₅₀s of 3 nM and 5 nM for LDHA and LDHB, respectively; (R)-GNE-140 is 18-fold more potent than S enantiomer.

HY-76948

5-R-Rivaroxaban	Factor Xa	Cardiovascular Disease
5-R-Rivaroxaban is (R)-enantiomer of Rivaroxaban. Rivaroxaban (BAY 59-7939) is a highly potent and selective, direct Factor Xa (FXa) inhibitor, achieving a strong gain in anti-FXa potency (IC₅₀ 0.7 nM; K_i 0.4 nM).

HY-136588

trans-R-138727MP Prasugrel metabolite R-138727MP	P2Y Receptor	Cardiovascular Disease
trans-R-138727MP (Prasugrel metabolite R-138727MP) is the active metabolite derivative of Prasugrel (HY-15284). Prasugrel, a thienopyridine and prodrug, inhibits platelet function. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation.

HY-15267A

(24R)-MC 976
VD/VDR Metabolic Disease

(24R)-MC 976 is a Vitamin D3 derivative.

HY-13856

(R)-PS210	PDK-1	Cancer
(R)-PS210, the R enantiomer of PS210 (compound 4h-eutomer), is a substrate-selective allosteric activator of PDK1 with an AC₅₀ value of 1.8 μM. (R)-PS210 targets to the PIF-binding pocket of PDK1. PIF: The protein kinase C-related kinase 2 (PRK2)-interacting fragment.

HY-14802

Talarozole R enantiomer (R)-Talarozole	Cytochrome P450	Cancer
Talarozole R enantiomer is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid for the treatment of psoriasis and acne.

HY-U00213

Furaprofen R803	HCV	Infection
Furaprofen (R803) is an effective HCV replication inhibitor. Furaprofen (R803) is substantially more potent against genotype 1a and 1b replicons (EC₅₀, ~30 nM) than against the genotype 2a replicon (EC₅₀, ~1,000 nM).

HY-13662B

(R)-Lansoprazole
Dexlansoprazole
Proton Pump Inflammation/Immunology

(R)-Lansoprazole is a proton pump inhibitor which prevents the stomach from producing acid.

HY-109785A

(R)-Gyramide A hydrochloride
(R)-Gyramide A hydrochloride is a bacterial DNA gyrase inhibitor that disrupts supercoiling activity with an IC₅₀ value of 3.3 µM. (R)-Gyramide A hydrochloride demonstrates antibacterial activity against E. coli, P. aeruginosa, and S. enterica (MICs of 10-80 µM). (R)-Gyramide A hydrochloride does not affect the closely related enzyme topoisomerase IV.

HY-100808

(R)-Serine	iGluR Endogenous Metabolite	Others
(R)-Serine, an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. (R)-Serine has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration.

HY-13259C

(R)-MG-132 (S,R,S)-(-)-MG-132; Z-Leu-D-leu-leu-al	Proteasome	Cancer
(R)-MG-132 ((S,R,S)-(-)-MG-132) is the enantiomer of MG-132. (R)-MG-132 is a proteasome inhibitor with weaker cell cytotoxicity than MG-132. (R)-MG-132 stereoisomer is a more potent proteasome inhibitor than MG-132.

HY-W002304

(R)-5-Oxopyrrolidine-2-carboxylic acid
Endogenous Metabolite Metabolic Disease

(R)-5-Oxopyrrolidine-2-carboxylic acid is an endogenous metabolite.

HY-116463B

(2S,3S)-E1R	Sigma Receptor	Neurological Disease
(2S,3S)-E1R (Compound 2d) is an enantiomer of E1R. (2S,3S)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders.

HY-40354D

(3R,4S)-Tofacitinib
JAK Inflammation/Immunology

(3R,4S)-Tofacitinib is an less active enantiomer of Tofacitinib. Tofacitinib inhibits JAK3 with IC₅₀ of 1 nM.

HY-N4266

Vinaginsenoside R8	Others	Cardiovascular Disease
Vinaginsenoside R8, a triterpenoid glycoside isolated from the rhizomes of Panacis majoris. Vinaginsenoside R8 displays activities against adenosine diphosphate (ADP)-induced platelet aggregation (IC₅₀=25.18 μM).

HY-12422C

(2S,3R)-Voruciclib
CDK Cancer

(2S,3R)-Voruciclib is the (2S,3R)-enantiomer of Voruciclib. (2S,3R)-Voruciclib is an orally active CDK inhibitor.

HY-W021425

(2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride	Endogenous Metabolite	Metabolic Disease
(2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride is an endogenous metabolite.

HY-108707

LY3130481	iGluR	Neurological Disease
LY3130481 is an AMPA receptor antagonist that is dependent upon transmembrane AMPA receptor regulatory protein (TARP) γ-8, selective inhibits AMPA/TARP γ-8 with an IC₅₀ of 65 nM.

HY-107479

(R)-JNJ-31020028	Neuropeptide Y Receptor	Neurological Disease
(R)-JNJ-31020028 is a high affinity, selective brain penetrant neuropeptide Y Y2 receptor antagonist, with pIC₅₀ values of 8.07, 8.22 and 8.21 for human, rat, and mouse Y2 receptor, respectively. (R)-JNJ-31020028 shows >100-fold selective versus human Y1, Y4, and Y5 receptors. (R)-JNJ-31020028 has antidepressant like effects.

HY-126047B

(R)-(+)-Anatabine	NF-κB Amyloid-β nAChR	Inflammation/Immunology Neurological Disease
(R)-(+)-Anatabine is an less active R-enantiomer of Anatabine. Anatabine is a potent α4β2 nAChR agonist. Anatabine inhibits NF-κB activation lower amyloid-β (Aβ) production by preventing the β-cleavage of amyloid precursor protein (APP). Anatabine has anti-inflammatory effects and has the potential for neurodegenerative disorders treatment.

HY-103096

R162
Others Cancer

R162 is a potent inhibitor of glutamate dehydrogenase 1 (GDH1/GLUD1), with anti-cancer properties.

HY-135397

(R)-Linezolid (R)-PNU-100766	Others	Infection
(R)-Linezolid is an impurity of Linezolid (PNU-100766). Linezolid, the first member of the class of oxazolidinone synthetic antibiotic, acts by inhibiting the initiation of bacterial protein synthesis.

HY-13030A

(R)-(-)-JQ1 Enantiomer	Epigenetic Reader Domain	Cancer
(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 potently decreases expression of both BRD4 target genes, whereas (R)-(-)-JQ1 Enantiomer has no effect.

HY-101116

GLP-1R Antagonist 1	Glucagon Receptor	Metabolic Disease
GLP-1R Antagonist 1 (compound 5d) is an orally active, CNS penetrant and non-competitive antagonist of glucagon-like peptide 1 receptor (GLP-1R), with an IC₅₀ of 650 nM.

HY-N4131

25R-Inokosterone
Others Others

25R-Inokosterone is a phytoecdysone isolated from Achyranthis Radix.

HY-12506A

Naspm trihydrochloride 1-Naphthylacetyl spermine trihydrochloride	iGluR	Neurological Disease
Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.

HY-110203

R-7050
TNF-α Antagonist III
TNF Receptor Cancer

R-7050 (TNF-α Antagonist III) is a tumor necrosis factor receptor (TNFR) antagonist with greater selectivity toward TNFα.
HY-50949A

Bay 65-1942 R form
IKK Inflammation/Immunology

Bay 65-1942 R form is the less active R-form of Bay 65-1942. Bay 65-1942 is an ATP-competitive and selective IKKβ inhibitor.

HY-17429

Flecainide acetate R-818	Sodium Channel	Cardiovascular Disease
Flecainide acetate (R-818) is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential.

HY-108414

(R)-Equol
(+)-Equol
Estrogen Receptor/ERR Cancer

(R)-Equol is an agonist of both ERα and ERβ with K_is of 27.4 and 15.4 nM, respectively.

HY-12506

Naspm 1-Naphthylacetyl spermine	iGluR	Neurological Disease
Naspm (1-Naphthyl acetyl spermine), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.

HY-12509

PEPA	iGluR	Neurological Disease
PEPA is an allosteric modulator of AMPA receptors; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity.

HY-113108

(R)-3-Hydroxyisobutyric acid	Endogenous Metabolite	Metabolic Disease
(R)-3-Hydroxyisobutyric acid is an intermediate in the pathways of l-valine and thymine and plays an important role in the diagnosis of the very rare inherited metabolic diseases 3-hydroxyisobutyric aciduria and methylmalonic semialdehyde dehydrogenase deficiency.

HY-N6924

Zingibroside R1	HIV	Infection Metabolic Disease
Zingibroside R1 is dammaranae-type triterpenoid saponin, isolated from rhizomes, taproots, and lateral roots of Panax japonicas C. A. Meyer, shows excellent anti-tumor effects as well as anti-angiogenic activity. Zingibroside R1 possesses some anti-HIV-1 activity. Zingibroside R1 has inhibitory effects on the 2-deoxy-D-glucose (2-DG) uptake by EAT cells (IC₅₀=91.3 μM).

HY-13058B

(R)-ADX-47273
mGluR Neurological Disease

(R)-ADX-47273 is a potent mGluR5 positive allosteric modulator, with an EC₅₀ of 168 nM for potentiation .
HY-B0454

Miconazole
R18134
Fungal Bacterial Antibiotic Infection

Miconazole (R18134) is an imidazole antifungal agent. Miconazole also has antibacterial effects.

HY-17355B

Dexpramipexole (R)-Pramipexole; R-(+)-Pramipexole; KNS-760704	Dopamine Receptor	Neurological Disease
Dexpramipexole(KNS-760704), also known as R-(+)-Pramipexole, is a neuroprotective agent and weak non-ergoline dopamine agonist. IC50 Value:

HY-78847

2R,4S-Sacubitril	Others	Cardiovascular Disease
2R,4S-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and Drug Administration for use in combination with valsartan for the treatment of patients with heart failure.

HY-N1400

(20R)-Ginsenoside Rh1	Others	Cancer
(20R)-Ginsenoside Rh1, the R isomer of Ginsenoside Rh1 isolated from Panax Ginseng, inhibits the thrombin-induced conversion of fibrinogen to fibrin.

HY-10216

Refametinib R enantiomer BAY 869766 R enantiomer; RDEA119 R enantiomer	MEK	Cancer
Refametinib R enantiomer is a MEK inhibitor extracted from patent WO2007014011A2, compound 1022, has an EC₅₀ of 2.0-15 nM.

HY-12067

R406	Syk Apoptosis	Cancer
R406 is a competitive Syk inhibitor for ATP binding with a K_i of 30 nM, potently inhibits Syk kinase activity in vitro with an IC₅₀ of 41 nM, measured at an ATP concentration corresponding to its K_m value.

HY-141186A

(R)-TCO-OH
PROTAC Linker Cancer

(R)-TCO-OH is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-B0418A

Loperamide hydrochloride R-18553 hydrochloride	Opioid Receptor Autophagy	Metabolic Disease Neurological Disease
Loperamide (hydrochloride) (R-18553 (hydrochloride)) is an opioid receptor agonist. Loperamide hydrochloride is a selective and competitive human intestinal carboxylesterases (hiCE) inhibitor. Loperamide hydrochloride has anti-diarrheal effect.

HY-W010841

Levocetirizine dihydrochloride (R)-Cetirizine dihydrochloride	Histamine Receptor	Endocrinology Inflammation/Immunology
Levocetirizine dihydrochloride ((R)-Cetirizine dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Levocetirizine dihydrochloride is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine dihydrochloride has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria.

HY-B0814

Levocetirizine (R)-Cetirizine	Histamine Receptor	Inflammation/Immunology Endocrinology
Levocetirizine ((R)-Cetirizine) is a third-generation peripheral H1-receptor antagonist. Levocetirizine is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria.

HY-17354

(R)-Baclofen
STX209
GABA Receptor Neurological Disease

(R)-Baclofen(STX209) is a selective GABAB receptor agonist.

HY-10167A

Tecalcet Hydrochloride R-568 (hydrochloride)	CaSR	Others
Tecalcet Hydrochloride (R 568 Hydrochloride), an orally active calcimimetic compound, allosterically and positively modulates the calcium-sensing receptor (CaSR). Tecalcet Hydrochloride (R 568 Hydrochloride) increases the sensitivity to activation by extracellular Ca²⁺.

HY-P1039

R18 PHCVPRDLSWLDLEANMCLP	Others	Cancer
R18 is a peptide antagonists of 14-3-3, with a K_D of 70-90 nM. R18 efficiently blocks the binding of 14-3-3 to the kinase Raf-1, a physiological ligand of 14-3-3, and effectively abolished the protective role of 14-3-3 against phosphatase-induced inactivation of Raf-1.

HY-14664B

(3R,5S)-Fluvastatin (3R,5S)-XU 62-320 free acid	HMG-CoA Reductase (HMGCR) Autophagy	Cancer Cardiovascular Disease
(3R,5S)-Fluvastatin is the 3R,5S-isomer Fluvastatin. Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC₅₀ of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway.

HY-124906

JAMI1001A	iGluR	Neurological Disease
JAMI1001A is a positive allosteric modulator of AMPA receptor. JAMI1001A efficaciously modulates AMPA receptor deactivation and desensitization of both flip and flop receptor isoforms.

HY-B1370B

(R)-Hydroxychloroquine (R)-HCQ	Parasite Toll-like Receptor (TLR) SARS-CoV Autophagy	Infection
(R)-Hydroxychloroquine is the enantiomer of Hydroxychloroquine. Hydroxychloroquine is a synthetic antimalarial drug which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro.

HY-B0330D

(R)-Ofloxacin
Dextrofloxacin
Bacterial Infection

(R)-Ofloxacin (Dextrofloxacin) is an antibiotic useful for the treatment of a number of bacterial infections. Antibacterial activity.

HY-P9917

Tocilizumab Anti-Human IL6R, Humanized Antibody	Interleukin Related	Cancer Inflammation/Immunology
Tocilizumab (Anti-Human IL6R, Humanized Antibody) is an anti-human interleukin-6 receptor (IL-6R) neutralizing antibody, prevents binding of IL-6 to the IL-6R, thereby inhibiting both classic and trans-signaling. Tocilizumab (Anti-Human IL6R, Humanized Antibody) can be used for the treatment of rheumatoid arthritis. Tocilizumab is remarkablely effective for the study of severe COVID-19 (coronavirus disease).

HY-101354

R-IMPP
Ser/Thr Protease Cancer Cardiovascular Disease

R-IMPP is an anti-secretagogue of PCSK9 (IC₅₀=4.8 μM), which targets the 80S ribosome to inhibit PCSK9 protein translation.
HY-12422B

(2S,3R)-Voruciclib hydrochloride
CDK Cancer

(2S,3R)-Voruciclib hydrochloride is the enantiomer of Voruciclib hydrochloride. (2S,3R)-Voruciclib is an orally active CDK inhibitor.

HY-112316A

(R)-BAY1238097	Epigenetic Reader Domain	Cancer
(R)-BAY1238097 is the R-isomer with lower activity of BAY1238097. BAY1238097 is a potent and selective inhibitor of BET binding to histones and has strong anti-proliferative activity in different AML (acute myeloid leukemia) and MM (multiple myeloma) models through down-regulation of c-Myc levels and its downstream transcriptome.

HY-12597

Quisqualic acid L-Quisqualic acid	iGluR mGluR	Neurological Disease
Quisqualic acid (L-Quisqualic acid), a natural analog of glutamate, is a potent and pan two subsets (iGluR and mGluR) of excitatory amino acid (EAA) agonist with an EC₅₀ of 45 nM and a K_i of 10 nM for mGluR1R. Quisqualic acid is isolated from the fruits of Quisqualis chinensis.

HY-17039

Alcaftadine R89674	Histamine Receptor	Inflammation/Immunology Endocrinology
Alcaftadine(R89674) is a H1 histamine receptor antagonist, which is used to prevent eye irritation brought on by allergic conjunctivitis.

HY-15609

AZD-3463
ALK/IGF1R inhibitor
ALK IGF-1R Autophagy Cancer Endocrinology

AZD-3463 is an ALK/IGF1R inhibitor which overcomes multiple mechanisms of acquired resistance to crizotinib.

HY-13038B

Fostamatinib disodium hexahydrate R788 disodium hexahydrate	Syk	Inflammation/Immunology
Fostamatinib disodium hexahydrate (R788 disodium hexahydrate), a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM.

HY-N0909

Notoginsenoside R2 20(S)-Notoginsenoside R2; Ginsenoside Ng-R2	Others	Neurological Disease
Notoginsenoside R2 is a newly isolated notoginsenoside from Panax notoginseng, showed neuroprotective effects against 6-OHDA-induced oxidative stress and apoptosis.

HY-32337

Tacalcitol 1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3	VD/VDR	Metabolic Disease
Tacalcitol (1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3) promotes normal bone development by regulating calcium.

HY-112218A

(R)-MIK665
Bcl-2 Family Cancer

(R)-MIK665 is the less active enantiomer of MIK665. MIK665 is a special Mcl-1 inhibitor with an IC₅₀ of 1.81 nM.
HY-U00249

Saperconazole
R66905
Fungal Infection

Saperconazole (R66905) is a broad-spectrum antifungal triazole and has potent activity against Aspergillus with an MIC₉₀ of 0.19 mg/L.
HY-15067

DNQX
FG 9041
iGluR Cancer

DNQX (FG 9041) is a AMPA receptor antagonists.

HY-100999

(R)-(-)-α-Methylhistamine dihydrobromide	Histamine Receptor	Neurological Disease
(R)-(-)-α-Methylhistamine dihydrobromide is a potent and selective H3 histamine receptor agonist with a K_d of 50.3 nM. (R)-(-)-α-Methylhistamine dihydrobromide can cross the blood-brain barrier, and can enhance memory retention, attenuates memory impairment in rats.

HY-15415

KB-R7943 mesylate	Na+/Ca2+ Exchanger Autophagy	Cancer
KB-R7943 mesylate is a widely used inhibitor of the reverse Na⁺/Ca²⁺ exchanger (NCX_rev) with IC₅₀ of 5.7±2.1 µM. KB-R7943 mesylate induces cancer cell death via activating the JNK pathway and blocking autophagic flux.

HY-14417A

(1R,2S)-VU0155041
mGluR Neurological Disease

(1R,2S)-VU0155041, Cis regioisomer of VU0155041, is a partial mGluR4 agonist with an EC₅₀ of 2.35 μM.

HY-112219A

H3R-IN-1 Hydrochloride	Histamine Receptor	Inflammation/Immunology Endocrinology
H3R-IN-1 Hydrochloride is a histamine receptor 3 (H3R) inverse agonist extracted from patent WO2013107336A1, compound example 2.

HY-P2247

JTP10-△-R9 TFA
JNK Cancer

JTP10-△-R9 TFA is a selective JNK2 peptide inhibitor, with an IC₅₀ of 89 nM, exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3.

HY-101682B

(R)-SCH 42495	Others	Others
(R)-SCH 42495 is the less active enantiomer of SCH 42495. SCH 42495 is an orally active neutral metalloendopeptidase (NEP) inhibitor with antihypertensive effect. SCH 42495 is the orally active ethylester prodrug of SCH 42354.

HY-100822

(R)-(+)-HA-966 (+)-HA-966	iGluR	Neurological Disease
(R)-(+)-HA-966 ((+)-HA-966) is a partial agonist/antagonist of glycine site of the N-methyl-D-aspartate (NMDA) receptor complex. (R)-(+)-HA-966 selectively blocks the activation of the mesolimbic dopamine system by amphetamine. (R)-(+)-HA-966 can cross the blood-brain barrier and has the potential for neuropathic and acute pain.

HY-112895A

(R)-UT-155
Androgen Receptor Cancer

(R)-UT-155 (compound 11) is a selective androgen receptor degrader (SARD) ligand. Less active than the S-isomer.

HY-U00117

Lusaperidone R107474	Adrenergic Receptor	Neurological Disease Endocrinology
Lusaperidone (R107474) is an α2 adrenergic receptor antagonist with K_is of 0.13 and 0.15 nM for α2A and α2C, respectively.

HY-10502

Tipifarnib R115777; IND 58359	Farnesyl Transferase	Cancer
Tipifarnib (R115777) binds to and inhibits farnesyltransferase (FTase) with IC₅₀ of 0.6 nM. Tipifarnib is a nonpeptidomimetic quinolinone with potential antineoplastic activity.

HY-100207

CP21R7
CP21
GSK-3 Cancer

CP21R7 is potent GSK-3β inhibitor, with an IC₅₀ of 1.8 nM; CP21R7 also shows inhibitory activitiy against PKCα, with an IC₅₀ of 1900 nM.

HY-126047A

(R,S)-Anatabine	Others	Inflammation/Immunology
(R,S)-Anatabine is a a minor tobacco alkaloid found in the Solanaceae family of plants that can be used as a specific marker for the detection of tobacco use.

HY-U00214

Ibafloxacine
R835; S25930
Bacterial Infection

Ibafloxacine (R835) is a fluoroquinolone antibiotic agent that is developed exclusively for veterinary use.
HY-112134A

(R)-CSN5i-3
Others Cancer

(R)-CSN5i-3 is the (R)-enantiomer of CSN5i-3. CSN5i-3 is a potent, selective and orally available inhibitor of CSN5.
HY-100785

gamma-DGG
γDGG; γ-D-Glutamylglycine
iGluR Neurological Disease

gamma-DGG is a competitive AMPA receptor blocker.

HY-18340

(R)-CR8 CR8, (R)-Isomer	CDK Apoptosis	Cancer Neurological Disease
(R)-CR8 (CR8), a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R)-CR8 (CR8) inhibits CDK1/cyclin B (IC₅₀=0.09 μM), CDK2/cyclin A (0.072 μM), CDK2/cyclin E (0.041 μM), CDK5/p25 (0.11 μM), CDK7/cyclin H (1.1 μM), CDK9/cyclin T (0.18 μM) and CK1δ/ε (0.4 μM). (R)-CR8 (CR8) induces apoptosis and has neuroprotective effect.

HY-12772

Hydroxy Itraconazole Itraconazole metabolite Hydroxy Itraconazole; R-63373	Fungal Drug Metabolite	Others
Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.

HY-U00181

Fludazonium chloride R23633	Fungal	Infection
Fludazonium chloride (R23633) is an anti-fungal agent, which can be used in the treatment and prevention of superficial and systemic fungal infections.

HY-15150

Bemcentinib
R428; BGB324
TAM Receptor Cancer

Bemcentinib (R428) is a potent and selective inhibitor of Axl with an IC₅₀ of 14 nM.

HY-N7025

Suavissimoside R1	Others	Neurological Disease
Suavissimoside R1, isolated from the roots of Rubus parvifollus, possesses potent neuroprotective activity and has the potential to treat anti-Parkinson's disease drug.

HY-N2296

(2R,3R)-3,7-Dihydroxy-2-(4-hydroxyphenyl)-5-methoxy-8-(3-methylbut-2-en-1-yl)chroman-4-one	Others	Others
(2R,3R)-3,7,4'-Trihydroxy-5-methoxy-8-prenylflavanone can be used in a flame retardant for transparent polycarbonate products or in elevator illumination devices research.

HY-W050145

(1R,2S,3S,4R,5S)-6,8-Dioxabicyclo[3.2.1]octane-2,3,4-triol	Endogenous Metabolite	Metabolic Disease
(1R,2S,3S,4R,5S)-6,8-Dioxabicyclo[3.2.1]octane-2,3,4-triol is an endogenous metabolite.

HY-14190

Valategrast R-411 free base	Integrin	Inflammation/Immunology
Valategrast (R-411 free base) is a potent and orally active integrin α4β1 (VLA-4) and α4β7 dual antagonist. Valategrast has the potential for Chronic obstructive pulmonary disease (COPD) and asthma treatment.

HY-30216

(R)-Leucic acid
D-α-Hydroxyisocaproic acid
Endogenous Metabolite Others

(R)-Leucic acid is an amino acid metabolite.

HY-10791

Ritanserin R 55667	5-HT Receptor Histamine Receptor Dopamine Receptor Adrenergic Receptor	Neurological Disease
Ritanserin (R 55667) is a highly potent, relatively selective, orally active, long acting antagonist of 5-HT₂ receptor, with an IC₅₀ of 0.9 nM, less active on Histamine H₁, Dopamine D₂, Adrenergic α₁, Adrenergic α₂ receptors.

HY-B0769

Phenylephrine (R)-(-)-Phenylephrine; L-Phenylephrine	Adrenergic Receptor	Cardiovascular Disease Endocrinology
(R)-(-)-Phenylephrine is a selective α₁-adrenoceptor agonist primarily used as a decongestant.

HY-P1175

L-R4W2
TRP Channel Neurological Disease

L-R4W2 is a potent antagonist of vanilloid receptor 1 (VR1, TRPV1), with an IC₅₀ of 0.1 μM. L-R4W2 may act as a potent analgesic.

HY-17039S

Alcaftadine-D3 R89674-D3	Histamine Receptor	Endocrinology Inflammation/Immunology
Alcaftadine-D3 (R89674-D3) is a deuterium labeled Alcaftadine. Alcaftadine (HY-17039) is a H1 histamine receptor antagonist.

HY-101216

Org-26576
iGluR Neurological Disease

Org-26576 is a AMPA receptor positive allosteric modulator.
HY-50081

CCR2-RA-[R]
CCR Inflammation/Immunology Endocrinology

CCR2-RA-[R] is an allosteric antagonist of the C-C chemokine receptor type 2 (CCR2) with an IC₅₀ of 103 nM.

HY-12532

Astemizole R 43512	Histamine Receptor Potassium Channel	Inflammation/Immunology Endocrinology
Astemizole (R 43512), a second-generation antihistamine drug to diminish allergic symptoms with a long duration of action, is a histamine H1-receptor antagonist, with an IC₅₀ of 4 nM. Astemizole also shows potent hERG K⁺ channel blocking activity with an IC₅₀ of 0.9 nM. Astemizole has antipruritic effects.

HY-14664C

(3S,5R)-Fluvastatin sodium (3S,5R)-XU 62-320	HMG-CoA Reductase (HMGCR)	Cancer Cardiovascular Disease
(3S,5R)-Fluvastatin sodium ((3S,5R)-XU 62-320) is the (3S,5R)-enantiomer of Fluvastatin. Fluvastatin is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC₅₀ of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway.

HY-N1401

20(R)-Ginsenoside Rh2	MMP Apoptosis HSV	Cancer Infection Inflammation/Immunology
20(R)-Ginsenoside Rh2, a matrix metalloproteinase (MMP) inhibitor, acts as a cell antiproliferator. It has anticancer effects via blocking cell proliferation and causing G1 phase arrest. 20(R)-Ginsenoside Rh2 induces apoptosis, and has anti-inflammatory and antioxidative activity. 20(R)-Ginsenoside Rh2 inhibits the replication and proliferation of mouse and human gammaherpesvirus 68 (MHV-68) with an IC₅₀ of 2.77 μM for murine MHV-68.

HY-11108

R406 free base
Syk Apoptosis Inflammation/Immunology Cancer

R406 free base is a potent Syk inhibitor with IC50 of 41 nM, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3.

HY-50202

Etomoxir (R)-(+)-Etomoxir	Apoptosis	Cancer Metabolic Disease
Etomoxir ((R)-(+)-Etomoxir) is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig.

HY-19282A

(5R)-BW-4030W92
Others Neurological Disease

(5R)-BW-4030W92 is the R enantiomer of BW-4030W92. BW-4030W92 is a non-selective, voltage-, and use-dependent sodium channel antagonist.

HY-B0418AS

Loperamide D6 hydrochloride R-18553 D6 hydrochloride	Opioid Receptor Autophagy	Metabolic Disease Neurological Disease
Loperamide D6 hydrochloride (R-18553 D6 hydrochloride) is a deuterium labeled Loperamide hydrochloride. Loperamide hydrochloride is an opioid receptor agonist for the treatment of diarrhea.

HY-N6262

20(S),24(R)-Ocotillol
Others Others

20(S),24(R)-Ocotillol is isolated from Panax ginseng.

HY-106019C

Liarozole dihydrochloride R75251 dihydrochloride	Cytochrome P450	Cancer Inflammation/Immunology
Liarozole dihydrochloride (R75251; R85246) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 17 ,20-lyase). Liarozole dihydrochloride prevents the catabolism of retinoic acid via inhibition of 4-hydroxylase and exhibits retinoid sparing and retinoid-mimetic effects in vivo. Liarozole dihydrochloride is an imidazole derivative; it is being investigated as a non-hormonal agent in prostate cancer and in the treatment of various other cancers and skin disorders.

HY-N4265

Vinaginsenoside R4	Others	Inflammation/Immunology
Vinaginsenoside R4, isolated from the leaves of hydroponic Panax ginseng. It has an inhibitory effect on melanin biosynthesis without any cytotoxic effects on the melan-a cells, and enhances the depigmentation on the zebrafish.

HY-111664

(R)-(+)-Citronellal (+)-Citronellal	Endogenous Metabolite	Metabolic Disease
(R)-(+)-Citronellal, isolated from citrus, lavender and eucalyptus oils, is a monoterpenoid and main component of citronellal oil with a distinct lemon scent. A flavouring agent. Used for insect repellent and antifungal properties.

HY-N6695

Aflatoxicol
Aflatoxin R0
Others Cancer

Aflatoxin (Aflatoxin R0) is a metabolite of aflatoxin B1 produced from Rhizopus spp, and is mutagenic and carcinogenic mycotoxin.

HY-B0602S

(R)-(-)-O-Desmethyl Venlafaxine D6	Drug Metabolite	Neurological Disease
(R)-(-)-O-Desmethyl Venlafaxine D6 is the deuterium labeled (R)-(-)-O-Desmethyl Venlafaxine. O-Desmethyl Venlafaxine is an active metabolite of Venlafaxine. Venlafaxine (HY-B0196) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.

HY-128732

rel-(2R,3S)-2,3-Dihydroxysuccinic acid hydrate
Endogenous Metabolite Metabolic Disease

rel-(2R,3S)-2,3-Dihydroxysuccinic acid (hydrate) is an endogenous metabolite.
HY-15015A

OT-R antagonist 2
Oxytocin receptor antagonist 2
Oxytocin Receptor Endocrinology

OT-R antagonist 2 is a nonpeptide low molecular weight OT-R antagonist.

HY-131082

(R)-8-Azido-2-(Fmoc-amino)octanoic acid	ADC Linker	Cancer
(R)-8-Azido-2-(Fmoc-amino)octanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-10934

Mibampator
LY451395
iGluR Neurological Disease

Mibampator (LY451395) is a potent and highly selective potentiator of the AMPA receptors.
HY-18689

SYM2206
iGluR Neurological Disease

SYM 2206 is a novel, potent, non-competitive AMPA receptor antagonist.
HY-100328

CB2R-IN-1
Cannabinoid Receptor Neurological Disease

CB2R-IN-1 is a potent cannabinoid CB₂ receptor inverse agonist with a K_i of 0.9 nM.

HY-13534A

Abarelix Acetate PPI 149 Acetate; R 3827 Acetate	GNRH Receptor	Cancer Endocrinology
Abarelix Acetate (PPI 149 Acetate; R 3827 Acetate) is a potent gonadotrophin-releasing hormone (GnRH) antagonist, used for prostate cancer research.

HY-12481A

SAR405 R enantiomer
Others Cancer

SAR405 R enantiomer is the less active enantiomer of SAR405. SAR405 is a PIK3C3/Vps34 inhibitor.

HY-18340A

(R)-CR8 trihydrochloride CR8, (R)-Isomer trihydrochloride	CDK Apoptosis	Cancer Neurological Disease
(R)-CR8 trihydrochloride (CR8 trihydrochloride), a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R)-CR8 trihydrochloride inhibits CDK1/cyclin B (IC₅₀=0.09 μM), CDK2/cyclin A (0.072 μM), CDK2/cyclin E (0.041 μM), CDK5/p25 (0.11 μM), CDK7/cyclin H (1.1 μM), CDK9/cyclin T (0.18 μM) and CK1δ/ε (0.4 μM). (R)-CR8 trihydrochloride induces apoptosis and has neuroprotective effect.

HY-B0454A

Miconazole nitrate R18134 nitrate	Fungal Bacterial Antibiotic	Infection
Miconazole nitrate (R18134 nitrate) is an imidazole antifungal agent. Miconazole nitrate also has antibacterial effects.

HY-40354B

(3S,4R)-Tofacitinib
JAK Inflammation/Immunology

(3S,4R)-Tofacitinib is an less active enantiomer of Tofacitinib. Tofacitinib inhibits JAK3 with IC₅₀ of 1 nM.

HY-113025A

L-hydroxylysine dihydrochloride (2S,5R)-5-Hydroxylysine dihydrochloride	Endogenous Metabolite	Others
L-hydroxylysine dihydrochloride ((2S,5R)-5-Hydroxylysine dihydrochloride), an amino acid, is exclusive to collagen protein, which is formed by posttranslational hydroxylation of some lysine residues.

HY-W010396

(R)-3-Hydroxy-4,4-dimethyldihydrofuran-2(3H)-one
Endogenous Metabolite Metabolic Disease

(R)-3-Hydroxy-4,4-dimethyldihydrofuran-2(3H)-one is an endogenous metabolite.

HY-10443

Balapiravir Ro 4588161; R1626	HCV DNA/RNA Synthesis	Infection
Balapiravir (Ro 4588161; R1626) is an orally active prodrug of a nucleoside analogue inhibitor of the RNA-dependent RNA polymerase (RdRp) of HCV (R1479; 4'-Azidocytidine). Balapiravir has anti-HCV activity.

HY-103319

Calmidazolium chloride R 24571	CaMK Autophagy	Cancer Neurological Disease
Calmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist, antagonizing CaM-dependent phosphodiesterase and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase with IC₅₀s of 0.15 and 0.35 μM, respectively. Also in anti-cancer research. Calmidazolium binds to CaMK with a K_d of 3 nM.

HY-114395A

(R)-NVS-ZP7-4	Others	Inflammation/Immunology
(R)-NVS-ZP7-4 is the R-isomer of NVS-ZP7-4. NVS-ZP7-4 is a Zinc transporter SLC39A7 (ZIP7) inhibitor that is also the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel druggable node in the Notch pathway.

HY-P1175A

L-R4W2 TFA
TRP Channel Neurological Disease

L-R4W2 TFA is a potent antagonist of vanilloid receptor 1 (VR1, TRPV1), with an IC₅₀ of 0.1 μM. L-R4W2 TFA may act as a potent analgesic.

HY-107613

R 59-022 DKGI-I; Diacylglycerol kinase inhibitor I	PKC 5-HT Receptor	Inflammation/Immunology
R 59-022 (DKGI-I) is a diacylglycerol kinase inhibitor (IC₅₀=2.8 μM). R 59-022 is a 5-HTR antagonist, and activates protein kinase C (PKC). R 59-022 potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils.

HY-15073

Becampanel
AMP 397
iGluR Neurological Disease

Becampanel (AMP397) is the first competitive AMPA antagonist and an antiepileptic agent.
HY-15015

OT-R antagonist 1
Oxytocin receptor antagonist 1
Oxytocin Receptor Endocrinology

OT-R antagonist 1 is a new potent and selective nonpeptide low molecular weight OT-R antagonist.

HY-123109

(S,R,S)-AHPC-Boc VH032-Boc	Ligand for E3 Ligase	Cancer
(S,R,S)-AHPC-Boc (VH032-Boc) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Boc is used in PROTAC technology.

HY-N2380

N-Benzoyl-(2R,3S)-3-phenylisoserine
Others Cancer

N-Benzoyl-(2R,3S)-3-phenylisoserine is a Taxol C-13 Side Chain and crucial for the strong antitumor activity of Taxol.

HY-15464

(R)-(-)-Gossypol AT-101; R-(-)-gossypol acetic acid	Bcl-2 Family Autophagy	Cancer
(R)-(-)-Gossypol (AT-101) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, Mcl-1 and Bcl-xL proteins with K_is of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.

HY-32338

Tacalcitol monohydrate 1,24(R)-Dihydroxyvitamin D3 monohydrate	VD/VDR	Metabolic Disease
Tacalcitol monohydrate (1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3) promotes normal bone development by regulating calcium.

HY-10014

R547	CDK GSK-3 Apoptosis	Cancer
R547 is a potent, selective and oral orally bioavailable ATP-competitive CDK inhibitor, with K_is of 2 nM, 3 nM and 1 nM for CDK1/cyclin B, CDK2/cyclin E and CDK4/cyclin D1, respectively.

HY-B0100A

Etomidate hydrochloride R16659 hydrochloride	GABA Receptor	Neurological Disease
Etomidate Hcl(R16659 Hcl) is a GABAA receptors agonist, which is a short acting intravenous anaesthetic agent used for the induction of general anaesthesia.

HY-106376

D,L-Buthionine-(S,R)-sulfoximine
Butionine sulfoximine
Ferroptosis Cancer

D,L-Buthionine-(S,R)-sulfoximine is a potent inhibitor of glutamylcysteine synthetase biosynthesis.

HY-135374

(3R,5S)-Atorvastatin sodium	Others	Metabolic Disease Inflammation/Immunology
(3R,5S)-Atorvastatin sodium is an impurity of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin inhibits human SV-SMC proliferation and invasion with IC₅₀s of 0.39 μM and 2.39 μM, respectively.

HY-14818

Laninamivir R 125489	Influenza Virus	Infection
Laninamivir (R 125489) is a potent influenza neuraminidase (NA) inhibitor with IC₅₀s of 0.90 nM, 1.83 nM and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively.

HY-14728

Aleglitazar
R1439; RO0728804
PPAR Metabolic Disease

Aleglitazar(R1439; RO-0728804) is a new dual PPAR-α/γ agonist with IC50 of 2.8 nM/4.6 nM.

HY-W010271

(2S,3R,4S)-4-Hydroxyisoleucine (2S,3R,4S)-4-Hydroxy-L-isoleucine	Others	Metabolic Disease
(2S,3R,4S)-4-Hydroxyisoleucine is an orally active compound isolated from Trigonella foenum-graecum, with anti-diabetes and anti-diabetic nephropathy activity.

HY-12499

(S)-Willardiine
(-)-Willardiine
iGluR Neurological Disease

(S)-Willardiine is a potent agonist of AMPA/kainate receptors with EC50 of 44.8 uM.

HY-19908B

(R)-BAY-85-8501	Others	Metabolic Disease
(R)-BAY-85-8501 is the less active Enantiomer of BAY-85-8501. BAY-85-8501 is a selective and potent inhibitor of Human Neutrophil Elastase (HNE), with an IC₅₀ of 65 pM.

HY-116830B

BRD5648 (R)-BRD0705	Others	Cancer
BRD5648 ((R)-BRD0705) is an inactive (R)-enantiomer of BRD0705. BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor with an IC₅₀ of 66 nM and a K_d of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC₅₀ of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML).

HY-N4264

Vinaginsenoside R3	Others	Inflammation/Immunology
Vinaginsenoside R3 is a saponin composition of roots of Panax ginseng. Ginsengs have been not only used as therapeutic agents with tonic, sedative, anti-fatigue, and anti-gastric ulcer effect but also marketed as dietary supplements and raw materials of health food.

HY-17354A

(R)-Baclofen hydrochloride
STX 209 hydrochloride
GABA Receptor Neurological Disease

(R)-Baclofen hydrochloride (STX 209 hydrochloride) is a selective GABAB receptor agonist.

HY-115681

(2R/S)-6-PNG 6-Prenylnaringenin	Calcium Channel
(2R/S)-6-PNG (6-Prenylnaringenin) is a Ca_v3.2 (T-type) Ca²⁺ channel blocker (IC₅₀=991 nM). (2R/S)-6-PNG suppresses neuropathic allodynia in mouse pain models.

HY-136163

(S,R,S)-AHPC-C2-NH2 dihydrochloride	E3 Ligase Ligand-Linker Conjugate	Cancer
(S,R,S)-AHPC-C2-NH2 dihydrochloride incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-OH can be used in the synthesis of a series of PROTACs.

HY-135383A

(3S,5R)-Pitavastatin calcium
Others Metabolic Disease

(3S,5R)-Pitavastatin cacium is the enantiomer of Pitavastatin. Pitavastatin is a potent HMG-CoA reductase inhibitor.

HY-101930B

(R)-BMS-816336	Others	Metabolic Disease
(R)-BMS-816336 (Compound 6n-1) is a potent and orally active inhibitor of human, mouse and cynomolgus monkey 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme with IC₅₀s of 14.5 nM, 50.3 nM and 16 nM, respectively .

HY-13534

Abarelix
R3827; PPI 149
GNRH Receptor Cancer Endocrinology

Abarelix (R3827; PPI 149) is a potent gonadotrophin-releasing hormone (GnRH) antagonist, used for prostate cancer treatment.

HY-B0661A

Tamsulosin hydrochloride (R)-(-)-YM12617; LY253351	Adrenergic Receptor	Neurological Disease Endocrinology
Tamsulosin hydrochloride((R)-(-)-YM12617;LY253351) is a selective α1 receptor antagonist.

HY-Z0081

2S,4R-Sacubitril	Others	Cardiovascular Disease
2S,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and Drug Administration for use in combination with valsartan for the treatment of patients with heart failure.

HY-10937

Farampator
CX-691; Org24448
iGluR Neurological Disease

Farampator (CX-691;Org24448) is an AMPA receptor positive modulator.

HY-108539A

(R)-CE3F4	Others	Metabolic Disease
(R)-CE3F4 is a potent and selective inhibitor of exchange protein directly activated by cAMP isoform 1 (Epac1), with an IC₅₀ of 4.2 μM, with 10-fold selectivity for Epac1 over Epac2 (IC₅₀, 44 μM). (R)-CE3F4 is more potent than racemic CE3F4 and (S)-CE3F4.

HY-14127

R121919 NBI30775	CRFR	Neurological Disease Endocrinology
R121919 (NBI30775) is a potent small-molecule CRF1 receptor antagonist with a K_i of 2 to 5 nM for the CRF1 receptor and over 1000-fold weaker activity at the CRF2 receptor, CRF-binding protein, or 70 other receptor types.

HY-10574

Rilpivirine R278474; TMC278; DB08864	HIV Reverse Transcriptase	Infection
Rilpivirine (R278474; TMC278) is a type of anti-HIV medicine called a non-nucleoside reverse transcriptase inhibitor (NNRTI).

HY-14531

Talarozole R115866	RAR/RXR Cytochrome P450 Autophagy	Inflammation/Immunology
Talarozole (R115866) is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA) which increases intracellular levels of endogenous all-trans retinoic acid (RA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC₅₀s of 5.4 and 0.46 nM, respectively.

HY-17514

Itraconazole R51211	Fungal Hedgehog Cytochrome P450 Autophagy Antibiotic	Infection Cancer
Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC₅₀ of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects.

HY-104028

BAY 73-6691
(R)-BAY 73-6691
Phosphodiesterase (PDE) Neurological Disease

BAY 73-6691 ((R)-BAY 73-6691) is a potent, brain penetrant, and selective PDE9A inhibitor.

HY-11018A

Risperidone hydrochloride R 64 766 hydrochloride	5-HT Receptor Dopamine Receptor P-glycoprotein	Neurological Disease
Risperidone hydrochloride (R 64 766 hydrochloride) 5-HT₂ receptor blocker, P-Glycoprotein inhibitor and potent dopamine D₂ receptor antagonist, with K_is of 4.8, 5.9 nM for 5-HT_2A and dopamine D₂ receptor, respectively.

HY-10240

Mericitabine RG 7128; R-7128; PSI 6130 diisobutyrate	HCV	Infection
Mericitabine (RG 7128; R-7128) is a nucleoside inhibitor of the HCV NS5B polymerase that acts as an RNA chain terminator and prevents elongation of RNA transcripts during replication.

HY-14451

PF-4778574
iGluR Neurological Disease

PF-4778574 is a positive allosteric modulation of AMPA receptor with EC₅₀ of 45 to 919 nM in differenct cells.
HY-10932

Aniracetam
Ro 13-5057
nAChR iGluR Neurological Disease

Aniracetam(Ro 13-5057) is a nootropics and neuroprotective drug, which is selectively modulates the AMPA receptor and nAChR.

HY-W013078

(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl ditetradecanoate	Endogenous Metabolite	Metabolic Disease
(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl ditetradecanoate is an endogenous metabolite.

HY-130798

(S,R,S)-AHPC-amido-C5-acid	E3 Ligase Ligand-Linker Conjugate	Cancer
(S,R,S)-AHPC-amido-C5-acid incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used to design XY028-133 (HY-129180).

HY-124909

(6R)-FR054	Apoptosis	Cancer
(6R)-FR054 is an active isomer of FR054. FR054 is an inhibitor of the HBP enzyme PGM3, with a remarkable anti-breast cancer effect. FR054induces endoplasmic reticulum (ER) stress and a ROS-dependent apoptosis.

HY-106376A

L-Buthionine-(S,R)-sulfoximine L-Buthionine sulfoximine	Ferroptosis	Cancer
L-Buthionine-(S,R)-sulfoximine is a cell-permeable, potent, fast acting and irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. The IC₅₀ value of L-Buthionine-(S,R)-sulfoximine on melanoma, breast and ovarian tumor specimens are 1.9 μM, 8.6 μM, and 29 μM, respectively.

HY-N2039

20(R)-Ginsenoside Rg2
Others Cancer

20(R)-Ginsenoside Rg2, isolated from Ginseng stems and leaves, shows inhibitory effects on lung cancer NCI-H1650 cells. Anti-cancer activities.
HY-131005

Ehp inhibitor 2
Ephrin Receptor Cancer

Ehp inhibitor 2 is a Eph family tyrosine kinase inhibitor.

HY-10443A

Balapiravir hydrochloride Ro 4588161 hydrochloride; R1626 hydrochloride	HCV DNA/RNA Synthesis	Infection
Balapiravir hydrochloride (Ro 4588161 hydrochloride; R1626 hydrochloride) is an orally active prodrug of a nucleoside analogue inhibitor of the RNA-dependent RNA polymerase (RdRp) of HCV (R1479; 4'-Azidocytidine). Balapiravir hydrochloride has anti-HCV activity.

HY-11018B

Risperidone mesylate R 64 766 mesylate	5-HT Receptor Dopamine Receptor P-glycoprotein	Neurological Disease
Risperidone mesylate(R 64 766 mesylate) is a serotonin 5-HT₂ receptor blocker, P-Glycoprotein inhibitor and potent dopamine D₂ receptor antagonist, with K_is of 4.8, 5.9 nM for 5-HT_2A and dopamine D₂ receptor, respectively.

HY-130849

(S,R,S)-AHPC-Me-C5-COOH	E3 Ligase Ligand-Linker Conjugate	Cancer
(S,R,S)-AHPC-Me-C5-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C5-COOH can be used in PROTAC DT2216 (HY-130604).

HY-17504D

(3S,5R)-Rosuvastatin	HMG-CoA Reductase (HMGCR) Potassium Channel Autophagy	Metabolic Disease Cardiovascular Disease
(3S,5R)-Rosuvastatin is the (3S,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor with an IC₅₀ of 11 nM. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC₅₀ of 195 nM. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin is very effective in lowering low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels.

HY-141016

(S,R,S)-AHPC-PEG2-acid
PROTAC Linker Cancer

(S,R,S)-AHPC-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-N1372

(R)-Fangchinoline Thalrugosine; Thaligine	Bacterial Antibiotic	Cancer Infection Inflammation/Immunology Cardiovascular Disease
(R)-Fangchinoline (Thalrugosine), a alkaloids from genus Stephania，exhibits antimicrobial and hypotensive activity. The roots and stems of several plants from genus Stephania are all used as traditional Chinese medicine and have been used for treatment of fever, diarrhea, dyspepsia and urinary disease.

HY-14266

Dapivirine TMC120; R147681	HIV Reverse Transcriptase	Infection
Dapivirine(TMC 120, TMC 120 R147681) is a NNRTI for HIV reverse transcriptase with IC50 of 24 nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates.

HY-108059

β-Cryptoxanthin (3R)-β-Cryptoxanthin	Endogenous Metabolite	Neurological Disease
β-Cryptoxanthin ((3R)-β-Cryptoxanthin), isolated from Satsuma mandarin orange, is an oxygenated carotenoid and a potent antioxidant. β-Cryptoxanthin has an anti-stress effect.

HY-106376B

D,L-Buthionine-(S,R)-sulfoximine hydrochloride Buthionine sulfoximine hydrochloride	Ferroptosis	Cancer
D,L-Buthionine-(S,R)-sulfoximine hydrochloride (Buthionine sulfoximine hydrochloride) is a potent inhibitor of glutamylcysteine synthetase biosynthesis.

HY-111787

CSF1R-IN-2	Src c-Met/HGFR c-Fms	Cancer
CSF1R-IN-2 (compound 5) is an oral-active inhibitor of SRC, MET and c-FMS, with IC₅₀ values of 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively.

HY-Z0075

(Z)2S,4R-Sacubitril	Others	Cardiovascular Disease
(Z)2S,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and Drug Administration for use in combination with valsartan for the treatment of patients with heart failure.

HY-130642

(S,R,S)-AHPC-Me-C10-Br	E3 Ligase Ligand-Linker Conjugate	Cancer
(S,R,S)-AHPC-Me-C10-Br is a synthesized E3 ligase ligand-linker conjugate. (S,R,S)-AHPC-Me-C10-Br incorporates a VHL E3 ligase linker and MS432 based on the MEK1/2 inhibitor PD0325901.

HY-109046

Tulrampator
CX-1632
iGluR Neurological Disease

Tulrampator (CX-1632) is an orally bioavailable positive AMPAR (allosteric modulator of AMPA receptor). Antidepressant.

HY-13987

(R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid D-phenylalanine analogue	Others	Others
(R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid is a constrained Phe analogue which can fold into a beta-bend and a helical structure, and to adopt a preferred side-chain disposition in the peptide.

HY-128836

(4R,5S)-Nutlin carboxylic acid MDM2 ligand 2; E3 ligase Ligand 15	Ligand for E3 Ligase	Cancer
(4R,5S)-Nutlin carboxylic acid (MDM2 ligand 2) is the Nutlin 3-based MDM2 ligand. (4R,5S)-Nutlin carboxylic acid can be connected to the ligand for protein by a linker to form PROTACs.

HY-14664CS

(3S,5R)-Fluvastatin D6 sodium (3S,5R)-XU 62-320 D6	HMG-CoA Reductase (HMGCR)	Cancer Cardiovascular Disease
(3S,5R)-Fluvastatin D6 sodium is the deuterium labeled (3S,5R)-Fluvastatin sodium. Fluvastatin is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC₅₀ of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway.

HY-W040240

(3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one
Endogenous Metabolite Metabolic Disease

(3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one is an endogenous metabolite.
HY-15068

NBQX
FG9202
iGluR Neurological Disease

NBQX (FG9202) is a highly selective and competitive AMPA receptor antagonist. NBQX has neuroprotective and anticonvulsant activity.

HY-14664DS

(3S,5R)-Fluvastatin D6 (3S,5R)-XU 62-320 free acid D6	Autophagy	Cancer Cardiovascular Disease
(3S,5R)-Fluvastatin D6 is the deuterium labeled (3S,5R)-Fluvastatin sodium. Fluvastatin is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC₅₀ of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway.

HY-130847

(S,R,S)-AHPC-Me-C10-NH2	E3 Ligase Ligand-Linker Conjugate	Cancer
(S,R,S)-AHPC-Me-C10-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C10-NH2 can be used in PROTAC MS432 (HY-130602).

HY-P0133

(Arg)9 Nona-L-arginine; Peptide R9	Others	Neurological Disease
(Arg)9 (Nona-L-arginine;Peptide R9) is a cell-penetrating peptide; exhibits neuroprotective activity with an IC₅₀ of 0.78 μM in the glutamic acid model.

HY-100703

Pipamperone Floropipamide; McN-JR 3345; R 3345	5-HT Receptor Dopamine Receptor	Neurological Disease
Pipamperone (Floropipamide; McN-JR 3345; R 3345) is a high-affinity antagonist of 5-HT_2A receptor (pK_i=8.2) and D₄ receptor (pK_i=8.0) and a low-affinity antagonist of D₂ receptor (pK_i=6.7).

HY-50202A

Etomoxir sodium salt (R)-(+)-Etomoxir sodium salt	Apoptosis	Metabolic Disease Cancer
Etomoxir sodium salt ((R)-(+)-Etomoxir sodium salt) is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig.

HY-113038

D-α-Hydroxyglutaric acid (R)-2-Hydroxypentanedioic acid	Reactive Oxygen Species ATP Synthase mTOR Endogenous Metabolite	Cancer Inflammation/Immunology Neurological Disease
D-α-Hydroxyglutaric acid ((R)-2-Hydroxypentanedioic acid) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a K_i of 10.87 mM. D-α-Hydroxyglutaric acid increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid binds and inhibits ATP synthase and inhibits mTOR signaling.

HY-13716

Noscapine (S,R)-Noscapine	Opioid Receptor Apoptosis	Cancer Inflammation/Immunology Neurological Disease
Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can crosse the blood-brain barrier.

HY-130640

(S,R,S)-AHPC-Me-C7 ester
E3 Ligase Ligand-Linker Conjugate Cancer

(S,R,S)-AHPC-Me-C7 ester is a E3 ligase ligand-linker conjugate used to synthesise BCL-X_L PROTAC degraders.

HY-N2185

(5R,6E)-5-Hydroxy-1,7-diphenyl-6-hepten-3-one	Others	Inflammation/Immunology
(5R,6E)-5-Hydroxy-1,7-diphenyl-6-hepten-3-one is the methylene chloride extract of Alpinia nutans, has antioxidant activity.

HY-15266

24R-Calcipotriol PRI 2202; Impurity D of Calcipotriol	VD/VDR	Cancer
24R-Calcipotriol(PRI 2202) is an impurity of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors.

HY-B0471

Phenylephrine hydrochloride (R)-(-)-Phenylephrine hydrochloride; L-Phenylephrine hydrochloride	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
(R)-(-)-Phenylephrine hydrochloride is a selective α₁-adrenoceptor agonist with pK_is of 5.86, 4.87 and 4.70 for α_1D, α_1B and α_1A receptors respectively.

HY-121879

SHP836
Phosphatase Cancer

SHP836 is a SHP2 allosteric inhibitor, with an IC₅₀ of 12 μM for the full length SHP2.

HY-114176B

(S,R,S)-AHPC-C4-NH2 dihydrochloride VH032-C4-NH2 dihydrochloride	E3 Ligase Ligand-Linker Conjugate	Cancer
(S,R,S)-AHPC-C4-NH2 dihydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for EED-Targeted PROTAC.

HY-114176A

(S,R,S)-AHPC-C4-NH2 VH032-C4-NH2	E3 Ligase Ligand-Linker Conjugate	Cancer
(S,R,S)-AHPC-C4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for EED-Targeted PROTAC.

HY-15464A

(R)-(-)-Gossypol acetic acid AT-101 (acetic acid); (-)-Gossypol acetic acid; (R)-Gossypol acetic acid	Bcl-2 Family Autophagy	Cancer
(R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, Mcl-1 and Bcl-xL proteins with K_is of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.

HY-103228

GYKI53655 hydrochloride
iGluR Neurological Disease

GYKI53655 hydrochloride is an α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) antagonist.

HY-15068A

NBQX disodium FG9202 disodium	iGluR	Neurological Disease
NBQX disodium (FG9202 disodium) is a highly selective and competitive AMPA receptor antagonist. NBQX disodium has neuroprotective and anticonvulsant activity.

HY-42680

(3S,4S,5R)-1,3,4,5,6-Pentahydroxyhexan-2-one
Tagatose, D- (8CI)
Endogenous Metabolite Metabolic Disease

(3S,4S,5R)-1,3,4,5,6-Pentahydroxyhexan-2-one is an endogenous metabolite.

HY-100542

D-α-Hydroxyglutaric acid disodium Disodium (R)-2-hydroxyglutarate	Reactive Oxygen Species ATP Synthase mTOR Endogenous Metabolite	Cancer Inflammation/Immunology Neurological Disease
D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a K_i of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling.

HY-10935

LY450108
iGluR Neurological Disease

LY450108 is an alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor potentiator.

HY-136183

(S,R,S)-AHPC-phenol-alkylC6-amine dihydrochloride VH032 phenol-alkylC6-amine dihydrochloride	E3 Ligase Ligand-Linker Conjugate
(S,R,S)-AHPC-phenol-alkylC6-amine (dihydrochloride) is a functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC. (S,R,S)-AHPC-phenol-alkylC6-amine incorporates an E3 ligase ligand plus an alkyl linker ready for conjugation to a target protein ligand.

HY-15956A

CPI-169 CPI 169 R-enantiomer	Histone Methyltransferase	Cancer
CPI-169 (CPI 169 R-enantiomer) is a novel and potent EZH2 inhibitor, with IC₅₀s of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively.

HY-B2246

L-Carnitine hydrochloride (R)-Carnitine hydrochloride	Endogenous Metabolite	Metabolic Disease
L-Carnitine hydrochloride ((R)-Carnitine hydrochloride), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine hydrochloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine hydrochloride is an antioxidant. L-Carnitine hydrochloride can ameliorate metabolic imbalances in many inborn errors of metabolism.

HY-101363

1-BCP Piperonylic acid piperidide	iGluR	Neurological Disease
1-BCP (Piperonylic acid piperidide) is a centrally active drug that modulates AMPA receptor gated currents. 1-BCP is a memory-enhancing agent.

HY-128941

CCK2R Ligand-Linker Conjugates 1	Drug-Linker Conjugates for ADC	Cancer
CCK2R Ligand-Linker Conjugates 1 is a ligand-linker conjugate, which conjugates to the cytotoxic antimicrotubule agents Desacetyl Vinblastine Hydrazide (DAVBH) and Tubulysin B Hydrazide (TubBH) via a hydrophilic peptide linker.

HY-13716A

Noscapine hydrochloride (S,R)-Noscapine hydrochloride	Opioid Receptor Apoptosis	Cancer Inflammation/Immunology Neurological Disease
Noscapine hydrochloride ((S,R)-Noscapine hydrochloride) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine hydrochloride exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine hydrochloride disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine hydrochloride possesses anticancer, neuroprotective, anti-inflammatory activities, and can crosse the blood-brain barrier.

HY-129941

(S,R,S)-AHPC-C10-NH2 VH032-C10-NH2	E3 Ligase Ligand-Linker Conjugate	Cancer
(S,R,S)-AHPC-C10-NH2 (VH032-C10-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for BET-Targeted PROTAC.

HY-129941A

(S,R,S)-AHPC-C10-NH2 dihydrochloride VH032-C10-NH2 dihydrochloride	E3 Ligase Ligand-Linker Conjugate	Cancer
(S,R,S)-AHPC-C10-NH2 dihydrochloride (VH032-C10-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for BET-Targeted PROTAC.

HY-126456

(S,R,S)-AHPC-propargyl VH032-propargyl; VHL ligand 7	Ligand for E3 Ligase	Cancer
(S,R,S)-AHPC-propargyl (VH032-propargyl) is a VHL ligand which is used in “click reaction” for PROTACs.

HY-112078

(S,R,S)-AHPC-Me VHL ligand 2; E3 ligase Ligand 1A	Ligand for E3 Ligase	Cancer
(S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC₅₀ <1 nM.

HY-15072

Zonampanel YM 872	iGluR	Metabolic Disease
Zonampanel (YM 872) is a selective antagonist of the glutamate receptor subtype, α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid *(AMPA) receptor*.

HY-103603B

(S,R,S)-AHPC-PEG2-NH2 dihydrochloride VH032-PEG2-NH2 dihydrochloride	E3 Ligase Ligand-Linker Conjugate	Cancer
(S,R,S)-AHPC-PEG2-NH2 dihydrochloride (VH032-PEG2-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs.

HY-19373

RWJ-445167 3DP-10017	Thrombin Factor Xa	Cardiovascular Disease
RWJ-445167 (3DP-10017) is a dual inhibitor of thrombin and factor Xa with K_i of 4.0 nM and 230 nM, respectively, exhibiting potent antithrombotic activity.

HY-16787

ICA-121431	Sodium Channel	Cardiovascular Disease
ICA-121431 is a nanomolar potent and broad-spectrum voltage-gated sodium channel (Na_v) blocker, shows equipotent selectivity for human Na_v1.1 and Na_v1.3 subtypes with IC₅₀ values of 13 nM and 23 nM, respectively. ICA-121431 shows less potent inhibition of Na_v1.2 (IC₅₀=240 nM) and 1,000 fold selectivity against Na_v1.4, Na_v1.6, and the TTX-resistant human Na_v1.5 and Na_v1.8 channels (IC₅₀s >10 µM).

HY-42424A

(S,R,S)-AHPC-Me dihydrochloride VHL ligand 2 dihydrochloride; E3 ligase Ligand 1 dihydrochloride	Ligand for E3 Ligase	Cancer
(S,R,S)-AHPC-Me dihydrochloride (VHL ligand 2 dihydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me dihydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC₅₀ <1 nM.

HY-112929B

(1S,2S,3R)-DT-061	Others	Cancer
(1S,2S,3R)-DT-061 is an enantiomer of DT-061. DT-061 is an orally bioavailable activator of protein phosphatase 2A (PP2A) and could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis.

HY-136184

(S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride VH032-phenol-C4-NH2 dihydrochloride	E3 Ligase Ligand-Linker Conjugate
(S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride is a functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC. (S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride incorporates an E3 ligase ligand plus an alkyl linker ready for conjugation to a target protein ligand.

HY-10933

Ampalex CX516; BDP 12; AMPAkine CX516	iGluR	Neurological Disease
Ampalex (Ampakine CX516; CX516; BDP 12) is an ampakine and nootropic that acts as an AMPA receptor positive allosteric modulator as a treatment for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI).

HY-12987S

Pimozide D4 R6238 D4	Dopamine Receptor Adrenergic Receptor STAT	Cancer Endocrinology Neurological Disease
Pimozide D4 (R6238 D4) is a deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with K_is of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a K_i of 39 nM; Pimozide also inhibits STAT3 and STAT5.

HY-14608

(S)-Glutamic acid (+)-L-Glutamic acid	Endogenous Metabolite iGluR Ferroptosis Apoptosis	Neurological Disease
(S)-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). (S)-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

HY-42424

(S,R,S)-AHPC-Me hydrochloride VHL ligand 2 hydrochloride; E3 ligase Ligand 1	Ligand for E3 Ligase	Cancer
(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me hydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC₅₀ <1 nM.

HY-15069A

Fanapanel hydrate ZK200775 (hydrate); MPQX hydrate	iGluR	Neurological Disease
Fanapanel hydrate (ZK200775 hydrate) is a highly selective AMPA/kainate antagonist with little activity against NMDA; have Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively.

HY-14608A

L-Glutamic acid monosodium salt Monosodium glutamate	iGluR Apoptosis Ferroptosis	Neurological Disease
L-Glutamic acid monosodium salt acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). (S)-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

HY-15069

Fanapanel ZK200775; MPQX	iGluR	Neurological Disease
Fanapanel (ZK200775) is a highly selective AMPA/kainate antagonist with little activity against NMDA; have Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively.

HY-U00439A

*Protein kinase inhibitors* 1 hydrochloride** (E)-5-((2-Oxo-6'-(piperazin-1-yl)-1,2-dihydro-[3,3'-bipyridin]-5-yl)methylene)thiazolidine-2,4-dione hydrochloride	DYRK	Cancer
Protein kinase inhibitors 1 hydrochloride is a potent HIPK2 inhibitor, with IC₅₀s of 136 and 74 nM for HIPK1 and HIPK2, and a K_d of 9.5 nM for HIPK2.

HY-41094

cis-Isolimonenol
(1S,4R)-p-Mentha-2,8-dien-1-ol
Others Others

cis-Isolimonenol ((1S,4R)-p-Mentha-2,8-dien-1-ol) is a chemical composition of essential oil.

HY-100218A

RSL3 (1S,3R)-RSL3	Glutathione Peroxidase Ferroptosis	Cancer
RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells.

HY-125845

(S,R,S)-AHPC VH032-NH2; VHL ligand 1	Ligand for E3 Ligase	Cancer
(S,R,S)-AHPC (VH032-NH2) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC₅₀ of 1.11 μM in Ba/F3 cells.

HY-125846

(S,R,S)-AHPC-PEG1-OTs VH032-PEG1-OTs; VHL Ligand-Linker Conjugates 2; E3 ligase Ligand-Linker Conjugates 51	E3 Ligase Ligand-Linker Conjugate	Cancer
(S,R,S)-AHPC-PEG1-OTs is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 1-unit PEG linker used in PROTAC technology.

HY-W012037

8-Hydroxyquinoline hemisulfate 8-Quinolinol hemisulfate	Bacterial Antibiotic	Infection
8-Hydroxyquinoline hemisulfate (8-Quinolinol hemisulfate) is a monoprotic bidentate chelating agent, exhibits antiseptic, disinfectant, and pesticide properties, functioning as a transcription inhibitor.

HY-101763A

(S,R,S)-AHPC hydrochloride VH032-NH2 hydrochloride; VHL ligand 1 hydrochloride	Ligand for E3 Ligase	Cancer
(S,R,S)-AHPC hydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC hydrochloride can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC₅₀ of 1.11 μM in Ba/F3 cells.

HY-101335

DCG-IV	mGluR	Neurological Disease
DCG-IV is a potent agonist of group II mGluRs with EC₅₀s of 0.35 and 0.09 μM for mGlu2R and mGlu3R, reapectively. DCG-IV is also a competitive antagonist at group I (IC₅₀: mGlu1R/5R=389/630 μM) and III receptors (IC₅₀: mGlu4R/6R/7R/8R= 22.5/39.6/40.1/32 μM). DCG-IV has anticonvulsive and neuroprotective effects.

HY-114379

AS2717638	LPL Receptor	Inflammation/Immunology
AS2717638 is an oral active and selective lysophosphatidic acid receptor 5 (LPA5) antagonist, with an IC₅₀ of 38 nM for hLPA5. AS2717638 also significantly improves PGE₂-, PGF_2α-, and AMPA-induced allodynia.

HY-12508

CMPDA
iGluR Neurological Disease

CMPDA is a positive allosteric modulator of AMPA receptors with EC50s of 45.4 ± 4.2 nM/63.4 ± 5.6 nM for GluA2i/GluA2o receptor.

HY-136006

(S,R,S)-AHPC-C6-NH2 dihydrochloride VH032-C6-NH2 dihydrochloride	E3 Ligase Ligand-Linker Conjugate	Cancer Inflammation/Immunology
(S,R,S)-AHPC-C6-NH2 dihydrochloride (VH032-C6-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for AKT PROTAC degrader. (S,R,S)-AHPC-C6-NH2 dihydrochloride is XF038-161A, example 6, extracted from patent WO2019173516A1.

HY-133487B

(S,R,S)-AHPC-C8-NH2 VH032-C8-NH2	E3 Ligase Ligand-Linker Conjugate	Cancer Inflammation/Immunology
(S,R,S)-AHPC-C8-NH2 (VH032-C8-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for AKT PROTAC degrader. (S,R,S)-AHPC-C8-NH2 is XF038-164A, example 8, extracted from patent WO2019173516A1.

HY-133487

(S,R,S)-AHPC-C8-NH2 dihydrochloride VH032-C8-NH2 dihydrochloride	E3 Ligase Ligand-Linker Conjugate	Cancer Inflammation/Immunology
(S,R,S)-AHPC-C8-NH2 dihydrochloride (VH032-C8-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for AKT PROTAC degrader. (S,R,S)-AHPC-C8-NH2 is XF038-164A, example 8, extracted from patent WO2019173516A1.

HY-130711

(S,R,S)-AHPC-C3-NH2 VH032-C3-NH2	E3 Ligase Ligand-Linker Conjugate	Cancer
(S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. (S,R,S)-AHPC-C3-NH2 can be used in the synthesis of a series of PROTACs, such as UNC6852 (HY-130708). UNC6852 is an EED-targeted bivalent chemical degrader.

HY-103608

(S,R,S)-AHPC-(C3-PEG)2-C6-Cl VHL Ligand-Linker Conjugates 11; E3 ligase Ligand-Linker Conjugates 11	E3 Ligase Ligand-Linker Conjugate	Cancer
(S,R,S)-AHPC-(C3-PEG)2-C6-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-(C3-PEG)2-C6-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays.

HY-101310

SYM 2081	iGluR	Neurological Disease
SYM 2081 is a high-affinity ligand and potent, selective agonist of kainate receptors, inhibits [³H]-kainate binding with an IC₅₀ of 35 nM, almost 3000- and 200-fold selectivity for kainate receptors over AMPA and NMDA receptors respectively.

HY-103599

(S,R,S)-AHPC-PEG2-N3 VH032-PEG2-N3; VHL Ligand-Linker Conjugates 6; E3 ligase Ligand-Linker Conjugates 13	E3 Ligase Ligand-Linker Conjugate	Cancer
(S,R,S)-AHPC-PEG2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in PROTAC technology.

HY-103601

(S,R,S)-AHPC-PEG4-N3 VH032-PEG4-N3; VHL Ligand-Linker Conjugates 5; E3 ligase Ligand-Linker Conjugates 4	E3 Ligase Ligand-Linker Conjugate	Others
(S,R,S)-AHPC-PEG4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.

HY-103600

(S,R,S)-AHPC-PEG1-N3 VH032-PEG1-N3; VHL Ligand-Linker Conjugates 9; E3 ligase Ligand-Linker Conjugates 3	E3 Ligase Ligand-Linker Conjugate	Cancer
(S,R,S)-AHPC-PEG1-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 1-unit PEG linker used in PROTAC technology.

HY-103598

(S,R,S)-AHPC-PEG3-N3 VH032-PEG3-N3; VHL Ligand-Linker Conjugates 8; E3 ligase Ligand-Linker Conjugates 12	E3 Ligase Ligand-Linker Conjugate	Cancer
(S,R,S)-AHPC-PEG3-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.

HY-103606

(S,R,S)-AHPC-PEG6-C4-Cl VH032-PEG6-C4-Cl; VHL Ligand-Linker Conjugates 10; E3 ligase Ligand-Linker Conjugates 9	PROTAC	Cancer
(S,R,S)-AHPC-PEG6-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 6-unit PEG linker. (S,R,S)-AHPC-PEG6-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays.

HY-103607

(S,R,S)-AHPC-PEG2-C4-Cl VH032-PEG2-C4-Cl; VHL Ligand-Linker Conjugates 7; E3 ligase Ligand-Linker Conjugates 10	PROTAC	Cancer
(S,R,S)-AHPC-PEG2-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-PEG2-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays.

HY-114176

(S,R,S)-AHPC-C4-NH2 hydrochloride VH032-C4-NH2 hydrochloride; VHL Ligand-Linker Conjugates 13; E3 ligase Ligand-Linker Conjugates 28	E3 Ligase Ligand-Linker Conjugate	Cancer
(S,R,S)-AHPC-C4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for EED-Targeted PROTAC.

HY-108494

CYM50260	LPL Receptor	Cardiovascular Disease
CYM50260 is a potent and exquisitely selective sphingosine-1-phosphate 4 receptor (S1P₄-R) agonist with an EC₅₀ of 45 nM. CYM50260 displays no activity against S1P₁-R, S1P₂-R, S1P₃-R and S1P₅-R.

HY-14645A

(+)-DHMEQ (1R,2R,6R)-Dehydroxymethylepoxyquinomicin; (1R,2R,6R)-DHMEQ	Keap1-Nrf2	Inflammation/Immunology
(+)-DHMEQ is an activator of antioxidant transcription factor Nrf2. (+)-DHMEQ is the enantiomer of (-)-DHMEQ. (-)-DHMEQ inhibits NF-kB than its enantiomer (+)-DHMEQ.

HY-103602A

(S,R,S)-AHPC-PEG3-NH2 VH032-PEG3-NH2; VHL Ligand-Linker Conjugates 1; E3 ligase Ligand-Linker Conjugates 5 Free Base	E3 Ligase Ligand-Linker Conjugate	Cancer
(S,R,S)-AHPC-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.

HY-103604A

(S,R,S)-AHPC-PEG4-NH2 VH032-PEG4-NH2; VHL Ligand-Linker Conjugates 4 ; E3 ligase Ligand-Linker Conjugates 7 Free Base	E3 Ligase Ligand-Linker Conjugate	Cancer
(S,R,S)-AHPC-PEG4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.

HY-P0227

SHU 9119	Others	Metabolic Disease
SHU 9119 is a potent human melanocortin 3 and 4 receptors (MC3/4R) antagonist and a partial *MC5R* agonist; with IC₅₀ values of 0.23, 0.06, and 0.09 nM for human MC3R, MC4R and MC5R, respectively.

HY-P1205A

MCH(human, mouse, rat) TFA	MCHR1 (GPR24)	Neurological Disease
MCH (human, mouse, rat) TFA is a potent peptide agonist of *MCH-R* and exhibits binding IC₅₀ values of 0.3nM and 1.5 nM for MCH1R and MCH2R, respectively. MCH (human, mouse, rat) is a highly sensitive to MCH-2R in a CHO cell line and monitoring mobilization of intracellular calcium with FLIPR, exhibits functional activation EC₅₀ values of 3.9 nM and 0.1nM for human MCH-1R and MCH-2R, respectively.

HY-P1205

MCH(human, mouse, rat)	MCHR1 (GPR24)	Neurological Disease
MCH (human, mouse, rat) is a potent peptide agonist of *MCH-R* and exhibits binding IC₅₀ values of 0.3nM and 1.5 nM for MCH1R and MCH2R, respectively. MCH (human, mouse, rat) is a highly sensitive to MCH-2R in a CHO cell line and monitoring mobilization of intracellular calcium with FLIPR, exhibits functional activation EC₅₀ values of 3.9 nM and 0.1nM for human MCH-1R and MCH-2R, respectively.

HY-103604

(S,R,S)-AHPC-PEG4-NH2 hydrochloride VH032-PEG4-NH2 hydrochloride; VHL Ligand-Linker Conjugates 4 hydrochloride; E3 ligase Ligand-Linker Conjugates 7	E3 Ligase Ligand-Linker Conjugate	Cancer
(S,R,S)-AHPC-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.

HY-103602

(S,R,S)-AHPC-PEG3-NH2 hydrochloride VH032-PEG3-NH2 hydrochloride; VHL Ligand-Linker Conjugates 1 hydrochloride; E3 ligase Ligand-Linker Conjugates 5	E3 Ligase Ligand-Linker Conjugate	Cancer
(S,R,S)-AHPC-PEG3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.

HY-19320

Orexin 2 Receptor Agonist	Orexin Receptor (OX Receptor)	Neurological Disease Endocrinology
Orexin 2 Receptor Agonist is a potent (EC50 on OX2R is 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio is 70) agonist.

HY-115644

BMS-470539 dihydrochloride	Melanocortin Receptor	Inflammation/Immunology
BMS-470539 dihydrochloride is a highly potent and selective melanocortin-1 receptor (MC-1R) agonist with an IC₅₀ of 120 nM, an EC₅₀ of 28 nM. BMS-470539 dihydrochloride does not activate MC-3R and is a very weak partial agonist at MC-4R and MC-5R. BMS-470539 dihydrochloride has potently anti-inflammatory properties.

HY-14788

Drinabant AVE1625	Cannabinoid Receptor	Metabolic Disease
Drinabant (AVE1625) is an orally active CB1 receptor antagonist. Drinabant (AVE1625) inhibits the agonist-stimulated calcium signal with IC₅₀ values of 25 nM and 10 nM for the hCB1-R and rCB1-R, respectively, and is ineffective for the hCB2-R.

HY-130654

(S,R,S)-AHPC-C2-PEG4-N3 VH032-C2-PEG4-N3	E3 Ligase Ligand-Linker Conjugate	Cancer
(S,R,S)-AHPC-C2-PEG4-N3 (VH032-C2-PEG4-N3) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-C2-PEG4-N3 can be used in the synthesis of vRucaparib-TP4 (HY-130647). vRucaparib-TP4 a highly potent PARP1 degrader with a half-maximal degrading concentration (DC₅₀) of 82 nM.

HY-108495

CYM50308	LPL Receptor	Cardiovascular Disease
CYM50308 is a potent, selective and high affinity sphingosine-1-phosphate receptor 4 (S1P₄-R) agonist with an EC₅₀ of 56 nM. CYM50308 displays 37-fold more selective for *S1P₄-R* than S1P₅-R. CYM50308 has no activity at S1P₁-R, S1P₂-R and S1P₃-R subtypes at concentrations up to 25 μM.

HY-136006A

(S,R,S)-AHPC-C6-NH2 hydrochloride VH032-C6-NH2 hydrochloride	E3 Ligase Ligand-Linker Conjugate	Cancer Inflammation/Immunology
(S,R,S)-AHPC-C6-NH2 hydrochloride (VH032-C6-NH2 hydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for AKT PROTAC degrader. (S,R,S)-AHPC-C6-NH2 hydrochloride is XF038-161A, example 6, extracted from patent WO2019173516A1.

HY-130711A

(S,R,S)-AHPC-C3-NH2 TFA VH032-C3-NH2 TFA	E3 Ligase Ligand-Linker Conjugate	Cancer
(S,R,S)-AHPC-C3-NH2 TFA (VH032-C3-NH2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. (S,R,S)-AHPC-C3-NH2 can be used in the synthesis of a series of PROTACs, such as UNC6852 (HY-130708). UNC6852 is an EED-targeted bivalent chemical degrader.

HY-133487A

(S,R,S)-AHPC-C8-NH2 hydrochloride VH032-C8-NH2 hydrochloride	E3 Ligase Ligand-Linker Conjugate	Cancer Inflammation/Immunology
(S,R,S)-AHPC-C8-NH2 hydrochloride (VH032-C8-NH2 hydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for AKT PROTAC degrader. (S,R,S)-AHPC-C8-NH2 hydrochloride is XF038-164A, example 8, extracted from patent WO2019173516A1.

HY-110402

(S,R,S)-AHPC TFA VH032-NH2 TFA; VHL ligand 1 TFA	Ligand for E3 Ligase	Cancer
(S,R,S)-AHPC TFA (VH032-NH2 TFA) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC TFA can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC₅₀ of 1.11 μM in Ba/F3 cells.

HY-12475

Mutant IDH1-IN-1	Isocitrate Dehydrogenase (IDH)	Cancer
Mutant IDH1-IN-1 is a mutant-selective IDH1 inhibitor with with IC₅₀s of 4, 42, 80 and 143 nM against mutant IDH1 R132C/R132C, IDH1 R132H/R132H, IDH1 R132H/WT and wild type IDH1, respectively.

HY-130271

(S,R,S)-AHPC-PEG5-COOH VH032-PEG5-COOH; VHL Ligand-Linker Conjugates 16; E3 Ligase Ligand-Linker Conjugates 58	E3 Ligase Ligand-Linker Conjugate	Cancer
(S,R,S)-AHPC-PEG5-COOH (VH032-PEG5-COOH) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 5-unit PEG linker used in PROTAC technology.

HY-108400

SCH-23390 maleate R-(+)-SCH-23390 maleate	Dopamine Receptor 5-HT Receptor Potassium Channel	Neurological Disease
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is a potent and selective dopamine D₁-like receptor antagonist with K_is of 0.2 nM and 0.3 nM for the D₁ and D₅ receptor, respectively. SCH-23390 maleate is a potent and high efficacy human 5-HT_2C receptor agonist with a K_i of 9.3 nM. SCH-23390 maleate also binds with high affinity to the 5-HT₂ and 5-HT_1C receptors. SCH-23390 maleate inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC₅₀ of 268 nM.

HY-19545A

SCH-23390 hydrochloride R-(+)-SCH-23390 hydrochloride	Dopamine Receptor 5-HT Receptor Potassium Channel	Neurological Disease
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) is a potent and selective dopamine D₁-like receptor antagonist with K_is of 0.2 nM and 0.3 nM for the D₁ and D₅ receptor, respectively. SCH-23390 hydrochloride is a potent and high efficacy human 5-HT_2C receptor agonist with a K_i of 9.3 nM. SCH-23390 hydrochloride also binds with high affinity to the 5-HT₂ and 5-HT_1C receptors. SCH-23390 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC₅₀ of 268 nM.

HY-N0221

Daurisoline
(R,R)-Daurisoline
Autophagy Potassium Channel Cancer

Daurisoline is a hERG inhibitor and also an autophagy blocker.

HY-135813

LtaS-IN-1	Bacterial	Infection
LtaS-IN-1 (compound 1771) is a potent small-molecule inhibitor of Lipoteichoic acid (LTA) synthesis in multidrug-resistant (MDR) E. faecium and by altering the cell wall morphology. LtaS-IN-1 alone inhibits Enterococcus.spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 combination with antibiotics abolishs multidrug-resistant E. faecium growth almost completely.

HY-125957

A-3 hydrochloride	PKA Casein Kinase CaMK PKC	Others
A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It against PKA (K_i=4.3 µM), casein kinase II (K_i=5.1 µM) and myosin light chain kinase (MLCK) (K_i=7.4 µM). A-3 hydrochloride also inhibits PKC and casein kinase I with K_i values of 47 µM and 80 µM, respectively.

HY-103605

(S,R,S)-AHPC-C6-PEG3-C4-Cl VH032-C6-PEG3-C4-Cl; VHL Ligand-Linker Conjugates 12; E3 ligase Ligand-Linker Conjugates 8	PROTAC	Cancer
(S,R,S)-AHPC-C6-PEG3-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker. (S,R,S)-AHPC-C6-PEG3-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays.

HY-10936

S 18986	iGluR	Neurological Disease
S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of *AMPA-type* receptors. S 18986 shows cognitive enhancing properties in rodents. S 18986 activates the release of noradrenaline and acetylcholine in rat hippocampus and enhances rat memory in object-recognition tests.

HY-130816

(S,R,S)-AHPC-O-Ph-PEG1-NH2 VH032-O-Ph-PEG1-NH2	E3 Ligase Ligand-Linker Conjugate	Cancer
(S,R,S)-AHPC-O-Ph-PEG1-NH2 (VH032-O-Ph-PEG1-NH2) is E3 ligase ligand-linker conjugate and incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-O-Ph-PEG1-NH2 is used in PROTAC EED degrader-1 (HY-130614). PROTAC EED degrader-1 is a PROTAC targeting EED with a pK_D of 9.02.

HY-123960

Raphin1	Phosphatase	Neurological Disease
Raphin1 is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B *(R15B). Raphin1 binds strongly to the R15B-PP1c holophosphatase (K_d*=33 nM), and shows ~30-fold selective in binding R15B-PP1c over R15A-PP1c. Raphin1 crosses the blood-brain barrier, and reduces organismal and molecular deficits in a mouse model of a protein misfolding disease.

HY-123960A

Raphin1 acetate	Phosphatase	Neurological Disease
Raphin1 acetate is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 acetate binds strongly to the R15B-PP1c holophosphatase (K_d=33 nM), and shows ~30-fold selective in binding R15B-PP1c over R15A-PP1c. Raphin1 acetate crosses the blood-brain barrier, and reduces organismal and molecular deficits in a mouse model of a protein misfolding disease.

HY-116819

VU0453379	Glucagon Receptor	Metabolic Disease
VU0453379 is a highly selective and central nervous system (CNS) penetrant positive allosteric modulator (PAM) of glucagon-like peptide-1R (GLP-1R) with an EC₅₀ of 1.3 μM.

HY-105272

Loreclezole R 72063	GABA Receptor	Neurological Disease
Loreclezole, an antiepileptic compound, is a selective GABA_A receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors.

HY-B0203

Nebivolol
R 065824
Adrenergic Receptor Cardiovascular Disease Endocrinology

Nebivolol selectively inhibits β1- adrenergic receptor with IC50 of 0.8 nM.

HY-B0122

Topiramate McN 4853; RWJ 17021	iGluR GABA Receptor Sodium Channel Calcium Channel Potassium Channel Carbonic Anhydrase	Neurological Disease
Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of *kainate/AMPA* receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase.

HY-103603A

(S,R,S)-AHPC-PEG2-NH2 VH032-PEG2-NH2 ; VHL Ligand-Linker Conjugates 3 ; E3 ligase Ligand-Linker Conjugates 6 Free Base	E3 Ligase Ligand-Linker Conjugate	Cancer
(S,R,S)-AHPC-PEG2-NH2 (VH032-PEG2-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs.

HY-101708

N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea	Others	Neurological Disease
N-[(1R)-4-[(Aminoiminomethyl)amino]-1-[[[(1R)-1-(4-hydroxyphenyl)ethyl]amino]carbonyl]butyl]-α-phenylbenzeneacetamide is an anticonvulsant agent with potential for the treatment of generalized tonic-clonic and partial seizures.

HY-103603

(S,R,S)-AHPC-PEG2-NH2 hydrochloride VH032-PEG2-NH2 hydrochloride; VHL Ligand-Linker Conjugates 3 hydrochloride; E3 ligase Ligand-Linker Conjugates 6	E3 Ligase Ligand-Linker Conjugate	Cancer
(S,R,S)-AHPC-PEG2-NH2 hydrochloride (VH032-PEG2-NH2 hydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs.

HY-12085S2

(Rac)-Apremilast D5 (Rac)-CC-10004 D5	Others	Inflammation/Immunology
(Rac)-Apremilast D5 ((Rac)-CC-10004 D5) is a deuterium labeled (R)-Apremilast. (R)-Apremilast ((R)-CC-10004) is a enantiomer of Apremilast.

HY-117244

AZD7507
c-Fms Cancer

AZD7507 is a potent and orally active CSF-1R inhibitor, with antitumor activity.

HY-10624

THIQ	Melanocortin Receptor	Metabolic Disease
THIQ is the first selective agonist of the melanocortin-4 receptor (MC4R), with high affinity and potency for hMC4R (IC₅₀=1.2 nM, EC₅₀=2.1 nM) and rMC4R (IC₅₀=0.6 nM, EC₅₀=2.9 nM). THIQ maintains low potency at MC1R, MC3R and MC5R. THIQ plays a role in eliciting erectile activity in rodents. THIQ acts as a pharmacoperone of the MC4R rescuing the cell surface expression and signaling of some intracellularly retained MC4R mutants.

HY-N0095

(S)-10-Hydroxycamptothecin 10-HCPT; 10-Hydroxycamptothecin	Topoisomerase Apoptosis	Cancer
(S)-10-Hydroxycamptothecin (10-HCPT;10-Hydroxycamptothecin) is a DNA topoisomerase I inhibitor of isolated from the Chinese plant Camptotheca accuminata. (S)-10-Hydroxycamptothecin exhibits a remarkable apoptosis-inducing effect. (S)-10-Hydroxycamptothecin has the potential for hepatoma, gastric carcinoma, colon cancer and leukaemia treatment.

HY-101918

DS-1040 Tosylate	Others	Cardiovascular Disease
DS-1040 Tosylate is an orally active, selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) with IC₅₀s of 5.92 nM and 8.01 nM for human and rat TAFIa. DS-1040 Tosylate is a fibrinolysis enhancer for thromboembolic diseases.

HY-18728

STF-31
GLUT Autophagy Cancer

STF-31 is a selective inhibitor of glucose transporter 1 (GLUT1), with an IC₅₀ of 1μM^[1][2].

HY-136055

(S,R,S)-AHPC-C5-COOH VH032-C5-COOH	E3 Ligase Ligand-Linker Conjugate HIF/HIF Prolyl-Hydroxylase	Cancer
(S,R,S)-AHPC-C5-COOH (VH032-C5-COOH) is a synthesized E3 ligase ligand-linker conjugate, contains the VH032 VHL-based ligand and a linker to form PROTACs. VH-032 is a selective and potent inhibitor of VHL/HIF-1α interaction with a K_d of 185 nM, has the potential for the study of anemia and ischemic diseases.

HY-12790

CB1-IN-1 BPRCB1184	Cannabinoid Receptor	Neurological Disease
CB1-IN-1 (BPRCB1184) is a peripherally restricted CB1R antagonist, with Ki of 0.3 nM and 21 nM for CB1R (EC50 = 3 nM) and CB2R, respectively.

HY-19435A

GYKI-47261 dihydrochloride	iGluR Cytochrome P450	Neurological Disease
GYKI-47261 dihydrochloride is a competitive, orally active, and selective AMPA receptor antagonist with an IC₅₀ of 2.5 μM. GYKI-47261 has broad spectrum anticonvulsive activity and neuroprotective effects. GYKI-47261 dihydrochloride is also a potent inducer of CYP2E1.

HY-P1540

Angiotensin III, human, mouse	Angiotensin Receptor	Cardiovascular Disease Endocrinology
Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT₂R) agonist, with IC₅₀s of 0.648 nM and 21.1 nM for AT₂R and AT₁R, respectively.

HY-107623

TC-MCH 7c	MCHR1 (GPR24)	Metabolic Disease
TC-MCH 7c, a phenylpyridone derivative, is an orally available, selective and brain-penetrable *MCH₁R* antagonist with an IC₅₀ of 5.6 nM for hMCH₁R. TC-MCH 7c has K_is of 3.4 nM and 3.0 nM of human and mouse MCH₁R, respectively.

HY-10165

PSI-6130
R 1656
HCV Infection

PSI-6130 is a potent and selective inhibitor of HCV NS5B polymerase, and inhibits HCV replication with a mean IC₅₀ of 0.6 μM.

HY-B1655

Fluspirilene R 6218; Redeptin	Calcium Channel	Neurological Disease
Fluspirilene is a non-competitive antagonist of L-type calcium channels with an IC₅₀ of 0.03 μM. Fluspirileneis a long-acting injectable depot antipsychotic drug used for schizophrenia.

HY-130638

(S,R,S)-AHPC-O-Ph-PEG1-NH-Boc VH032-O-Ph-PEG1-NH-Boc	E3 Ligase Ligand-Linker Conjugate	Cancer
(S,R,S)-AHPC-O-Ph-PEG1-NH-Boc (VH032-O-Ph-PEG1-NH-Boc) is a synthesized E3 ligase ligand-linker conjugate which is used for the EED-targeted PROTAC.

HY-19540

GSK864	Isocitrate Dehydrogenase (IDH)	Cancer
GSK864 is an isocitrate dehydrogenase 1 (IDH1) mutant inhibitor; inhibits IDH1 mutants R132C, R132H, and R132G with IC₅₀ values of 8.8, 15.2 and 16.6 nM.

HY-P2242A

RO27-3225 TFA	Melanocortin Receptor	Inflammation/Immunology Neurological Disease
RO27-3225 TFA is potent and selective melanocortin 4 receptor (MC4R) agonist with an EC₅₀ of 1 nM and 8 nM for *MC4R* and MC1R, respectively. RO27-3225 TFA shows ~30-fold selectivity for *MC4R* over MC3R. RO27-3225 TFA has neuroprotective and anti-inflammatory effects.

HY-104042

Vorasidenib AG-881	Isocitrate Dehydrogenase (IDH)	Cancer
Vorasidenib (AG-881) is an orally available, brain penetrant second-generation dual mutant isocitrate dehydrogenases 1 and 2 (mIDH1/2) inhibitor. Vorasidenib (AG-881) exhibits nanomolar inhibition of (D)-2-hydroxyglutarate (D-2-HG), and the IC₅₀ ranges of 0.04~22 nM against IDH1 R132C, IDH1 R132G, IDH1 R132H and IDH1 R132S and 7~14 nM against IDH2 R140Q and 130 nM against IDH2 R172K.

HY-90009C

ent-Tadalafil ent-IC-351	Phosphodiesterase (PDE)	Cancer
ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS). compound (6R,12aS) is a potent PDE5 inhibitor with an IC₅₀ of 0.090 μM, while ent-Tadalafil is inactive at concentrations up to 10 µM.

HY-18099A

S1RA hydrochloride E-52862 hydrochloride	Sigma Receptor	Neurological Disease
S1RA hydrochloride (E-52862 hydrochloride) is a potent and selective sigma-1 receptor(σ1R, Ki=17 nM) antagonist, showed good selectivity against σ2R (Ki > 1000 nM).

HY-112679

GLP-1 receptor agonist 2
Glucagon Receptor Others

GLP-1 receptor agonist 2 is a glucagon-like peptide-1 receptor (GLP-1R) agonist.

HY-P0242

Neurokinin B	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin B belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect.

HY-107139

JNJ-10229570	Melanocortin Receptor	Endocrinology
JNJ-10229570 is an antagonist of melanocortin receptor 1 (MC1R) and melanocortin receptor 5 (MC5R), which inhibits sebaceous gland differentiation and the production of sebum-specific lipids. JNJ-10229570 inhibits the binding of ¹²⁵I-NDP-α-MSH to cells expressing human MC1R and MC5R, with IC₅₀ values of 270 nM and 200 nM, respectively.

HY-15494

Picropodophyllin AXL1717; Picropodophyllin; PPP	IGF-1R Apoptosis	Cancer Endocrinology
Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC₅₀ of 1 nM.

HY-18099

S1RA
E-52862
Sigma Receptor Neurological Disease

S1RA(E-52862) is a potent and selective sigma-1 receptor(σ1R, Ki=17 nM) antagonist, showed good selectivity against σ2R (Ki > 1000 nM).

HY-P0242A

Neurokinin B TFA	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin B TFA belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect.

HY-N3298

Meranzin	Adrenergic Receptor	Neurological Disease Cardiovascular Disease
Meranzin is an absorbed bioactive compound from the Traditional Chinese Medicine (TCM) Chaihu-Shugan-San (CSS). Meranzin, isolated from leaves of Murraya exotica L., regulates the shared alpha 2-adrenoceptor and involves the AMPA-ERK1/2–BDNF signaling pathway. Meranzin has the potential for the prevention of the comorbidity of atherosclerosis and depression.

HY-128523

Kgp-IN-1
Others Inflammation/Immunology

Kgp-IN-1 is an arginine-specific gingipain (Rgp) inhibitor extracted from patent WO2017201322A1, compound 13-R.
HY-128523A

Kgp-IN-1 hydrochloride
Others Inflammation/Immunology

Kgp-IN-1 hydrochloride is an arginine-specific gingipain (Rgp) inhibitor extracted from patent WO2017201322A1, compound 13-R.

HY-15583

Auristatin F	Microtubule/Tubulin ADC Cytotoxin	Cancer
Auristatin F is a potent cytotoxin. Auristatin F, a potent microtubule inhibitor and vascular damaging agent (VDA), can be used in antibody-drug conjugates (ADC).

HY-105272A

Loreclezole hydrochloride R 72063 hydrochloride	GABA Receptor	Neurological Disease
Loreclezole hydrochloride, an antiepileptic compound, is a selective GABA_A receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors.

HY-B0180A

Imiquimod hydrochloride R 837 hydrochloride	Toll-like Receptor (TLR) Autophagy HSV	Inflammation/Immunology
Imiquimod hydrochloride is an immune response modifier that acts as a toll-like receptor 7agonist.

HY-B0180B

Imiquimod maleate
R 837 maleate
Toll-like Receptor (TLR) Autophagy Inflammation/Immunology

Imiquimod maleate is an immune response modifier that acts as a toll-like receptor 7agonist.

HY-B0203A

Nebivolol hydrochloride R 065824 hydrochloride	Adrenergic Receptor Apoptosis	Cardiovascular Disease Endocrinology
Nebivolol hydrochloride selectively inhibits β1- adrenergic receptor with IC50 of 0.8 nM.

HY-18785

Indirubin Derivative E804	IGF-1R	Cancer Endocrinology
Indirubin Derivative E804 is a potent inhibitor of Insulin-like Growth Factor 1 Receptor *(IGF1R), with an IC₅₀* of 0.65 μM for IGF1R.

HY-133080

BAY-784
GNRH Receptor Cancer

BAY-784 is a gonadotropin releasing hormone receptor (GnRH-R) antagonist probe with IC₅₀s of 21 and 24 nM for human and rat GnRH-R, respectively.
HY-112484

RS-246204
Others Cancer

RS-246204 is a R-spondin-1 substitute compound that is able initiate small intestinal organoids without the use of the R-spondin-1 protein.
HY-101526

GENZ-882706
RA03546849
c-Fms Inflammation/Immunology

GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) Inhibitor extracted from patent WO 2017015267A1.

HY-12190A

JNJ-5207852 dihydrochloride	Histamine Receptor	Neurological Disease
JNJ-5207852 dihydrochloride is a selective and potent histamine H₃ receptor (H₃R) antagonist, with pK_is of 8.9, 9.24 for rat and human H₃R, respectively.

HY-107382

RF9	Neuropeptide Y Receptor	Endocrinology Neurological Disease Cardiovascular Disease
RF9 is a potent and selective Neuropeptide FF receptor antagonist, with K_i values of 58 and 75 nM for *hNPFF1R* and *hNPFF2R*, respectively.

HY-50866

NVP-AEW541
AEW541
IGF-1R Insulin Receptor Autophagy Cancer Endocrinology

NVP-AEW541 is a potent inhibitor of IGF-1R with IC₅₀ of 0.15 μM, also inhibits InsR, with IC₅₀ of 0.14 μM.
HY-125824

PF-06882961
Glucagon Receptor Metabolic Disease

PF-06882961 is a potent, orally bioavailable agonist of the glucagon-like peptide-1 receptor (GLP-1R).

HY-12190

JNJ-5207852	Histamine Receptor	Neurological Disease Endocrinology
JNJ-5207852 is a selective and potent histamine H₃ receptor (H₃R) antagonist, with pK_is of 8.9, 9.24 for rat and human H₃R, respectively.

HY-107382A

RF9 hydrochloride	Neuropeptide Y Receptor	Endocrinology Neurological Disease Cardiovascular Disease
RF9 hydrochloride is a potent and selective Neuropeptide FF receptor antagonist, with K_i values of 58 and 75 nM for *hNPFF1R* and *hNPFF2R*, respectively.

HY-109012A

Seltorexant hydrochloride JNJ-42847922 hydrochloride	Orexin Receptor (OX Receptor)	Endocrinology Neurological Disease
Seltorexant hydrochloride (JNJ-42847922 hydrochloride) is an orally active, high-affinity, and selective *OX2R* antagonist (pK_i values of 8.0 and 8.1 for human and rat OX2R). Seltorexant hydrochloride crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain.

HY-128656

LML134	Histamine Receptor	Neurological Disease Endocrinology
LML134 (compound 18b) is an orally active and high selective Histamine 3 receptor (H3R) inverse agonist with K_is of 0.3 nM and 12 nM for hH3R cAMP and hH3R bdg. LML134 penetrates the brain rapidly, leading to high H3R occupancy, and disengages its target with a fast kinetic profile. LML134 has the potential for excessive sleep disorders.

HY-112289

IDH889	Isocitrate Dehydrogenase (IDH)	Cancer
IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1). IDH889 has potent selectivity for IDH1 R132* mutations, with IC₅₀s of 0.02 μM, 0.072 μM and 1.38 μM for IDH1^R132H, IDH1^R132C and IDH1^wt, respectively. IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC₅₀ of 0.014 μM.

HY-101924

AVN-492
5-HT Receptor Neurological Disease

AVN-492 is a very specific and highly-selective antagonist with picomolar affinity to 5-HT6R (K_i=91 pM).

HY-P1504

β-Melanocyte Stimulating Hormone (MSH), human Beta-MSH (1-22) (human)	Melanocortin Receptor	Metabolic Disease Neurological Disease Endocrinology
β-Melanocyte Stimulating Hormone (MSH), human, a 22-residue peptide, acts as an endogenous melanocortin-4 receptor (MC4-R) agonist.

HY-10524

GSK1904529A	IGF-1R	Cancer Endocrinology
GSK1904529A is a selective inhibitor of IGF-1R and IR with IC50 of 27 nM and 25 nM, >100-fold more selective for IGF-1R/InsR than Akt1/2, Aurora A/B,B-Raf, CDK2, EGFR etc.

HY-10684

Pridopidine ACR16; ASP2314; FR310826	Dopamine Receptor	Neurological Disease
Pridopidine, a dopamine (DA) stabilizer, acts as a low affinity dopamine D2 receptor (D2R) antagonist. Pridopidine exerts high affinity towards sigma 1 receptor (S1R) with K_i between 70 and 80 nM, which is ~100× higher than its affinity toward D2R.

HY-P1504A

β-Melanocyte Stimulating Hormone (MSH), human TFA Beta-MSH (1-22) (human) TFA	Melanocortin Receptor	Metabolic Disease Neurological Disease Endocrinology
β-Melanocyte Stimulating Hormone (MSH), human TFA, a 22-residue peptide, acts as an endogenous melanocortin-4 receptor (MC4-R) agonist.

HY-107977

IDH1 Inhibitor 3
Isocitrate Dehydrogenase (IDH) Cancer

IDH1 Inhibitor 3 (compound 6f) is a mutant isocitric dehydrogenase 1 (IDH1) inhibitor, with an IC₅₀ of 45 nM for IDH1^R132H.

HY-15079

Talampanel GYKI-53773; LY-300164	iGluR	Neurological Disease
Talampanel (LY300164) is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor antagonis with anti-seizure activity. Talampanel (IVAX) has neuroprotective effects in rodent stroke models. Talampanel attenuates caspase-3 dependent apoptosis in mouse brain.

HY-P1852

TIP 39, Tuberoinfundibular Neuropeptide	Adenylate Cyclase	Neurological Disease
TIP 39, Tuberoinfundibular Neuropeptide is a neuropeptide and parathyroid hormone 2 receptor (PTH2R) agonist. TIP 39 is highly conserved among species. TIP39 from all species activates adenylyl cyclase and elevates intracellular calcium levels through parathyroid hormone 2 receptor (PTH2R).

HY-136181

YNT-185 dihydrochloride	Orexin Receptor (OX Receptor)	Neurological Disease
YNT-185 dihydrochloride is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC₅₀s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 dihydrochloride ameliorates narcolepsy-cataplexy symptoms in mouse models.

HY-A0024

Tolterodine (R)-(+)-Tolterodine; (+)-Tolterodine; (R)-Tolterodine; PNU-200583	mAChR	Neurological Disease
Tolterodine(PNU-200583) is a potent muscarinic receptor antagonists that show selectivity for the urinary bladder over salivary glands in vivo.

HY-11018

Risperidone R 64 766	5-HT Receptor Dopamine Receptor P-glycoprotein	Neurological Disease
Risperidone is a serotonin 5-HT₂ receptor blocker, P-Glycoprotein inhibitor and potent dopamine D₂ receptor antagonist, with K_is of 4.8, 5.9 nM for 5-HT_2A and dopamine D₂ receptor, respectively.

HY-18678A

Bremelanotide Acetate PT-141 Acetate	Melanocortin Receptor	Endocrinology
Bremelanotide Acetate (PT-141 Acetate), a synthetic peptide analogue of α-MSH, is an agonist at melanocortin receptors including the MC3R and MC4R for the treatment of sexual dysfunction.

HY-108841

Anakinra Raleukin; AMG-719	Others	Cancer Inflammation/Immunology
Anakinra (Raleukin) is a recombinant, nonglycosylated human interleukin-1 receptor (IL-1R) antagonist. Anakinra is the first biological agent to block the pro-inflammatory effects.

HY-122906

JTE-952	c-Fms	Inflammation/Immunology
JTE-952 is a potent, oral active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC₅₀ values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis.

HY-122470

Stampidine	Reverse Transcriptase HIV	Infection
Stampidine is a nucleoside reverse transcriptase inhibitor (NRTI) with potent and broad-spectrum anti-HIV activity. Stampidine inhibits the laboratory HIV-1 strain HTLV_IIIB (B-envelope subtype) and primary clinical isolates with IC₅₀s of 1 nM and 2 nM, respectively. Stampidine also inhibits NRTI-resistant primary clinical isolates and NNRTI-resistant clinical isolates with IC₅₀s of 8.7 nM and 11.2 nM, respectively.

HY-19870

Setmelanotide RM-493; BIM-22493; IRC-022493	Melanocortin Receptor	Metabolic Disease Endocrinology
Setmelanotide (RM-493) is a selective melanocortin 4 receptor (MC4R) agonist with EC₅₀s of 0.27 nM and 0.28 nM for human and rat MC4R, respectively.

HY-19870B

Setmelanotide acetate RM-493 acetate; BIM-22493 acetate; IRC-022493 acetate	Melanocortin Receptor	Endocrinology Metabolic Disease
Setmelanotide acetate (RM-493 acetate) is a selective melanocortin 4 receptor (MC4R) agonist with EC₅₀s of 0.27 nM and 0.28 nM for human and rat MC4R, respectively.

HY-135270

ADRA1D receptor agonist 1	Adrenergic Receptor	Endocrinology
ADRA1D receptor agonist 1 (compound (R)-9S) is a potent, selective and orally active α_1D adrenoceptor antagonist, with a K_i of 1.6 nM.

HY-100139

Diflumidone
R807
Others Inflammation/Immunology

Diflumidone is a non-steroidal antiinflammatory drug.
HY-B1077

Penfluridol
R-16341
Calcium Channel Autophagy Neurological Disease Cancer

Penfluridol is a highly potent, first generation diphenylbutylpiperidine antipsychotic.
HY-B0411

Domperidone
R33812
Dopamine Receptor Neurological Disease

Domperidone is a dopamine blocker and an antidopaminergic reagent.

HY-101094

Ocaperidone R79598	5-HT Receptor Dopamine Receptor	Neurological Disease
Ocaperidone is an effective antipsychotic agent, acting as a potent 5-HT₂ and dopamine D₂ antagonist, and a 5-HT_1A agonist, with K_is of 0.14 nM, 0.46 nM, 0.75 nM, 1.6 nM and 5.4 nM for 5-HT₂, a₁-adrenergic receptor, dopamine D₂, histamine H₁ and a₂-adrenergic receptor, respectively, and a pEC₅₀ and pK_i of 7.60 and 8.08 for h5-HT_1A.

HY-13784

Pirodavir R77975	Enterovirus	Infection
Pirodavir is a potent, broad-spectrum picornavirus inhibitor, and is highly active against both group A and group B rhinovirus serotypes. Pirodavir is very potent in a virus yield reduction assay (IC₉₀=2.3 nM).

HY-12987

Pimozide R6238	Dopamine Receptor Adrenergic Receptor STAT	Cancer Neurological Disease Endocrinology
Pimozide is a dopamine receptor antagonist, with K_is of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a K_i of 39 nM; Pimozide also inhibits STAT3 and STAT5.

HY-111950

(-)-Ibuprofenamide (R)-Ibuprofenamide	Others	Inflammation/Immunology
(-)-Ibuprofenamide is an amide prodrug of Ibuprofen with anti-inflammatory activity. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC₅₀s of 13 μM and 370 μM, respectively.

HY-101589

Sotirimod
R850
Others Inflammation/Immunology

Sotirimod is an immunostimulant, and can potentially treat for actinic keratosis.

HY-B0363

Nimesulide R805	COX	Inflammation/Immunology
Nimesulide is a selective COX-2 inhibitor, with IC₅₀s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC₅₀ >100 μM). Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties.

HY-100615

Revizinone
R80122
Phosphodiesterase (PDE) Cardiovascular Disease

Revizinone is a novel selective phosphodiesterase (PDE) inhibitor with IC50 values on this enzyme to 0.036 microM.

HY-B0901

Bromperidol R-11333	5-HT Receptor	Neurological Disease
Bromperidol is a butyrophenone derivative, is a potent and long-acting neuroleptic, used as an antipsychotic in the treatment of schizophrenia.

HY-10562

Ketanserin R41468	5-HT Receptor Potassium Channel Autophagy	Neurological Disease
Ketanserin is a selective 5-HT receptor antagonist. Ketanserin also blocks hERG current (I_hERG) in a concentration-dependent manner (IC₅₀=0.11 μM).

HY-100265

Cinperene
R5046
Others Neurological Disease

Cinperene is an atropine-like drug which can block pilocarpine-induced lacrimation and salivation.
HY-B1790

Terconazole
R42470
Fungal Infection

Terconazole is a broad-spectrum antifungal medication for the treatment of vaginal yeast infection.

HY-109012

Seltorexant JNJ-42847922	Orexin Receptor (OX Receptor)	Neurological Disease Endocrinology
Seltorexant (JNJ-42847922) is an orally active, high-affinity, and selective orexin-2 receptor (OX2R) antagonist (pK_i values of 8.0 and 8.1 for human and rat OX2R). Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain.

HY-136429

Ethylhydrocupreine Optochin	Bacterial Parasite	Infection
Ethylhydrocupreine (Optochin) is a quinine derivate with antimicrobial activity against *S. pneumoniae. Ethylhydrocupreine also possesses antimalarial activity against Plasmodium falciparum, with an IC₅₀* of 25.75 nM. Ethylhydrocupreine is a Gallus gallus taste 2 receptors (ggTas2r1, *ggTas2r2* and *ggTas2r7*) agonist.

HY-136429A

Ethylhydrocupreine hydrochloride Optochin hydrochloride	Bacterial Parasite	Infection
Ethylhydrocupreine hydrochloride (Optochin hydrochloride) is a quinine derivate with antimicrobial activity against *S. pneumoniae. Ethylhydrocupreine hydrochloride also possesses antimalarial activity against Plasmodium falciparum, with an IC₅₀* of 25.75 nM. Ethylhydrocupreine hydrochloride is a Gallus gallus taste 2 receptors (ggTas2r1, *ggTas2r2* and *ggTas2r7*) agonist.

HY-131312

Mutant IDH1-IN-6	Isocitrate Dehydrogenase (IDH)	Cancer
Mutant IDH1-IN-6 is a potent, selective and orally active mutant isocitrate dehydrogenase (IDH) inhibitor with IC₅₀s of 6.27 nM, 3.71 nM, 36.9 nM and 11.5 nM for IDH1 R132H, IDH1 R132C, IDH2 R140Q and IDH2 R172K mutant enzymes, respectively. Mutant IDH1-IN-6 is less active at inhibiting the IDH wild-type enzymes.

HY-N5056

DL-Goitrin	Others	Infection
DL-Goitrin, also called (R, S)- report by the spring, consists of the epigoitrin (reported by the R- Spring) and the spring (-S- reported by spring), and the two mutually isomers, and the mixture is the ingredient of Radix.

HY-18690

Enasidenib AG-221	Isocitrate Dehydrogenase (IDH)	Cancer
Enasidenib is an oral, potent, reversible, selective inhibitor of the IDH2 mutant enzymes, with IC₅₀s of 100 and 400 nM against IDH2^R140Q and IDH2^R172K, respectively.

HY-119942

c-Fms-IN-8
c-Fms Cancer

c-Fms-IN-8 (compound 4a) is a colony stimulating factor-1 receptor (CSF-1R, c-FMS) Type II inhibitor, with an IC₅₀ of 9.1 nM.

HY-116330A

Hyperforin dicyclohexylammonium salt Hyperforin DCHA	TRP Channel Calcium Channel	Neurological Disease
Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin dicyclohexylammonium salt modulates Ca²⁺ levels by activating Ca²⁺-conducting non-selective canonical TRPC6 channels. Hyperforin dicyclohexylammonium salt shows antidepressant effect.

HY-12872

Nazartinib EGF816	EGFR	Cancer
Nazartinib (EGF816) is a novel, covalent mutant-selective EGFR inhibitor, with K_i and K_inact of 31 nM and 0.222 min⁻¹ on EGFR(L858R/790M) mutant, respectively.

HY-19870A

Setmelanotide TFA RM-493 TFA; BIM-22493 TFA; IRC-022493 TFA	Melanocortin Receptor	Metabolic Disease Endocrinology
Setmelanotide TFA (RM-493 TFA) is a selective melanocortin 4 receptor (MC4R) agonist with EC₅₀s of 0.27 nM and 0.28 nM for human and rat MC4R, respectively.

HY-12872A

Nazartinib mesylate EGF816 (mesylate)	EGFR	Cancer
Nazartinib mesylate (EGF816 mesylate) is a novel, covalent mutant-selective EGFR inhibitor, with K_i and K_inact of 31 nM and 0.222 min⁻¹ on EGFR(L858R/790M) mutant, respectively.

HY-14799

Palovarotene
R 667; Ro 3300074
RAR/RXR Autophagy Others

Palovarotene is a nuclear retinoic acid receptor γ (RAR-γ) agonist.

HY-P0201A

Substance P TFA Neurokinin P TFA	Neurokinin Receptor	Endocrinology Neurological Disease
Substance P TFA (Neurokinin P TFA) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, *NK1R*).

HY-15749

XL228	Aurora Kinase Bcr-Abl IGF-1R Src	Cancer Endocrinology
XL228 is a multi-targeted tyrosine kinase inhibitor with IC₅₀s of 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, *IGF-1R, Src* and Lyn, respectively.

HY-18634

NSC319726 ZMC1	MDM-2/p53	Cancer
NSC319726 (ZMC1) is a mutant p53R175 reactivator; inhibits growth of fibroblasts expressing the p53R175 mutation (IC50 = 8 nM); shows no inhibition for p53 wild-type cells.

HY-111415

EGFR-IN-5
EGFR Cancer

EGFR-IN-5 is a EGFR inhibitor with IC₅₀s of 10.4, 1.1, 34, 7.2 nM for EGFR, EGFR^L858R, EGFR^L858R/T790M, and EGFR^{L858R/T790M/C797S}, respectively.

HY-12324

SB269652	Dopamine Receptor	Neurological Disease
SB269652 is the first drug-like allosteric modulator of the dopamine D2 receptor (D2R); a new chemical probe that can differentiate D2R monomers from dimers or oligomers depending on the observed pharmacology.

HY-128597

BRD-IN-3	Epigenetic Reader Domain	Cancer
BRD-IN-3 ((R,R)-36n) is a highly potent PCAF bromodomain (BRD) inhibitor, with an IC₅₀ of 7 nM. BRD-IN-3 also exhibits activity against GCN5 and FALZ.

HY-122190

TAK-071	mAChR	Neurological Disease
TAK-071 is a novel, potent and highly selective muscarinic acetylcholine receptor 1 (M1R) positive allosteric modulator. EC₅₀ of TAK-071 M1R agonist activities is 520 nM.

HY-P2259

TAT-GluA2 3Y	iGluR
TAT-GluA2 3Y is an inhibitor of AMPA receptor endocytosis. TAT-GluA2 3Y induces increased hind paw withdrawal latencies following thermal and mechanical stimuli in rats. TAT-GluA2 3Y also exhibits antinociceptive effects in a rat model of neuropathic pain. TAT-GluA2 3Y rescues pentobarbital-induced memory retrieval deficits in a rat model of learning and memory.

HY-11007

GNF-2
Bcr-Abl SARS-CoV Cancer

GNF-2 is a highly selective, allosteric, non-ATP competitive inhibitor of Bcr-Abl. GNF-2 inhibits Ba/F3.p210 proliferation with an IC₅₀ of 138 nM .

HY-12768

BLZ945	c-Fms	Cancer
BLZ945 is a potent, selective and brain-penetrant CSF-1R (c-Fms) inhibitor with an IC₅₀ of 1 nM, showing more than 1,000-fold selectivity against its closest receptor tyrosine kinase homologs.

HY-N0898A

(-)-Catechin (-)-Cianidanol; (-)-Catechuic acid	COX	Cancer
(-)-Catechin, isolated from green tea, is an isomer of Catechin having a trans 2S,3R configuration at the chiral center. Catechin inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 1.4 μM.

HY-19702

PKR-IN-2	Others	Cancer
PKR-IN-2 is a pyruvate kinase (PKR) activator, extracted from patent WO2014139144A1, compound 160, has an IC50 of ＜100 nM for. PKR (R510Q), PKR (R532W), PKR (WT), and PKR (WT Cell Based).

HY-15772A

Osimertinib mesylate AZD-9291 mesylate; Mereletinib mesylate	EGFR	Cancer
Osimertinib mesylate (AZD-9291 mesylate) is an irreversible and mutant selective EGFR inhibitor with IC₅₀s of 12 and 1 nM against EGFR^L858R and EGFR^L858R/T790M, respectively.

HY-14881A

Bedaquiline fumarate R403323; TMC207 fumarate; R207910 fumarate	Bacterial Antibiotic	Infection
Bedaquiline fumarate, a diarylquinoline antibiotic that targets ATP synthase, is effective for the treatment of Mycobacterium tuberculosis infections.

HY-A0124A

Sapropterin dihydrochloride 6R-BH4 dihydrochloride; 6R-Tetrahydro-L-biopterin dihydrochloride	Others	Cardiovascular Disease
Sapropterin dihydrochloride is a synthetic form of BH4 that is approved for the treatment of BH4 responsive PKU.

HY-10204

OSI-930	c-Fms c-Kit VEGFR Apoptosis	Cancer
OSI-930 is a potent inhibitor of Kit, KDR and CSF-1R with IC50 of 80 nM, 9 nM and 15 nM, respectively; also potent to Flt-1, c-Raf and Lck and low activity against PDGFRα/β, Flt-3 and Abl.

HY-15772

Osimertinib AZD-9291; Mereletinib	EGFR	Cancer
Osimertinib (AZD-9291) is an irreversible and mutant selective EGFR inhibitor with IC₅₀s of 12 and 1 nM against EGFR^L858R and EGFR^L858R/T790M, respectively.

HY-79077

Osimertinib dimesylate AZD-9291 (dimesylate); Mereletinib (dimesylate)	EGFR	Cancer
Osimertinib dimesylate (AZD-9291 dimesylate) is an irreversible and mutant selective EGFR inhibitor with IC₅₀s of 12 and 1 nM against EGFR^L858R and EGFR^L858R/T790M, respectively.

HY-116790A

(+)-Penbutolol (R)-Penbutolol; (+)-Isopenbutolol	Adrenergic Receptor	Metabolic Disease Endocrinology
(+)-Penbutolol is a β-adrenoceptor antagonist, with an IC₅₀ of 0.74 μM. (+)-Penbutolol is an optical isomer of l-penbutolol with Na⁺ channel-blocking action.

HY-13520

Nocodazole Oncodazole; R17934	Microtubule/Tubulin Bcr-Abl CRISPR/Cas9 Autophagy Apoptosis	Cancer
Nocodazole is a rapidly-reversible inhibitor of microtubule. Nocodazole binds to β-tubulin and disrupts microtubule assembly/disassembly dynamics, which prevents mitosis and induces apoptosis in tumor cells. Nocodazole inhibits Bcr-Abl, and activates CRISPR/Cas9.

HY-B1547A

Benzetimide hydrochloride
R4929
mAChR Neurological Disease

Benzetimide hydrochloride is a muscarinic acetylcholine receptor antagonist.

HY-Y0378

D-Leucine (R)-Leucine	Endogenous Metabolite	Neurological Disease
D-Leucine is a more potent anti-seizure agent than L-leucine. D-leucine potently terminates seizures even after the onset of seizure activity. D-leucine, but not L-leucine, reduces long-term potentiation but had no effect on basal synaptic transmission in vitro.

HY-N0596

Panaxadiol
20(R)-Panaxadiol
Others Cancer

Panaxadiol is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.
HY-12694

Prucalopride succinate
R-108512
5-HT Receptor Others

Prucalopride succinate is a selective, high affinity 5-HT4 receptor agonist with pKi of 8.6/8.1 for 5-HT4a/4b.

HY-14789

(R)-Elagolix NBI-56418	GNRH Receptor	Cancer Endocrinology
Elagolix is a highly potent, selective, orally-active, short-duration, non-peptide antagonist of the gonadotropin-releasing hormone receptor (GnRHR) (KD = 54 pM).

HY-104036

IDH-305	Isocitrate Dehydrogenase (IDH)	Cancer
IDH-305 is an orally available, mutant-selective and brain-penetrant IDH1 inhibitor that targets IDH1 (R132) mutation. IDH-305 exhibits greater than 200 fold selectivity for mutant IDH1 isoforms vs. WT (IC₅₀= 27 nM (IDH1^R132H), 28 nM (IDH1^R132C), 6.14 µM (IDH1^WT)).

HY-100274

Adenosine antagonist-1
Adenosine Receptor Neurological Disease

Adenosine antagonist-1 is an adenosine A3 receptor (AA3R) antagonist.
HY-112451

cFMS Receptor Inhibitor II
c-Fms Inflammation/Immunology

cFMS Receptor Inhibitor II is a CSF1R kinase inhibitor. CSF-1 is a cytokine.
HY-N6629

3'-Methoxyflavonol
Others Neurological Disease

3'-Methoxyflavonol is a selective agonist of neuromedin U 2 receptor (NMU2R).
HY-19670

Befetupitant
Ro67-5930
Neurokinin Receptor Neurological Disease Endocrinology

Befetupitant is a high-affinity, nonpeptide, competitive tachykinin 1 receptor (NK1R) antagonist.
HY-14432

Pavinetant
MLE-4901; AZD2624; AZD4901
Neurokinin Receptor Neurological Disease Endocrinology

Pavinetant (MLE-4901) is a neurokinin-3 receptor (NK3R) antagonist.

HY-107734

L 152804	Neuropeptide Y Receptor	Metabolic Disease Endocrinology
L 152804 is an orally active and selective neuropeptide Y Y5 receptor (NPY5-R) antagonist, with a K_i of 26 nM for hY5. L 152804 causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure.

HY-N0328

alpha-Mangostin α-Mangostin	Reactive Oxygen Species Apoptosis Bacterial Fungal Virus Protease	Cancer
alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a K_i of 2.85 μM.

HY-10262

BMS-536924	IGF-1R Insulin Receptor Apoptosis	Cancer Endocrinology
BMS-536924 is an orally active, competitive and selective insulin-like growth factor receptor (IGF-1R) kinase and insulin receptor (IR) inhibitor with IC₅₀s of 100 nM and 73 nM, respectively. BMS-536924 has anti-cancer activity.

HY-15164A

Icotinib BPI-2009	EGFR	Cancer
Icotinib (BPI-2009) is a potent and specific EGFR inhibitor with an IC₅₀ of 5 nM; also inhibits mutant EGFR^L858R, EGFR^L858R/T790M, EGFR^T790M and EGFR^L861Q.

HY-114459

Mutant IDH1-IN-4	Isocitrate Dehydrogenase (IDH)	Cancer
Mutant IDH1-IN-4 (compound 434) is an inhibitor of mutant Isocitrate dehydrogenase 1 (IDH 1), with IC₅₀ values of ≤ 0.5 μM for mutant IDH1 in R132H, HT1080 and U87R132H cells.

HY-10261A

Afatinib dimaleate BIBW 2992MA2	EGFR Autophagy	Cancer
Afatinib dimaleate is an irreversible EGFR family inhibitor with IC₅₀s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFR^wt, EGFR^L858R, EGFR^L858R/T790M and HER2, respectively.

HY-15164

Icotinib Hydrochloride BPI-2009H	EGFR	Cancer
Icotinib Hydrochloride (BPI-2009) is a potent and specific EGFR inhibitor with an IC₅₀ of 5 nM; also inhibits mutant EGFR^L858R, EGFR^L858R/T790M, EGFR^T790M and EGFR^L861Q.

HY-126297

c-Fms-IN-10	c-Fms	Cancer Inflammation/Immunology
c-Fms-IN-10 is the derivative of thieno [3,2-d] pyrimidine, an kinase inhibitor of FMS (Colony stimulating factor-1 receptor, CSF-1R) with IC₅₀ of 2 nM. c-Fms-IN-10 has anti-tumor activity.

HY-13972

Mutant IDH1 inhibitor
Isocitrate Dehydrogenase (IDH) Cancer

Mutant IDH1 inhibitor is a potent mutant IDH1 R132H inhibitor with IC₅₀ of < 72 nM.
HY-19632

Fezolinetant
ESN-364
Neurokinin Receptor Endocrinology

Fezolinetant is an antagonist of the neurokinin 3 receptor (NK3R), used for the treatment of menopausal hot flushes.

HY-16756

Toreforant JNJ-38518168	Histamine Receptor	Neurological Disease Endocrinology
Toreforant is a potent and selective histamine H₄ receptor (H4R) antagonist, with a K_i at the human receptor of 8.4 nM.

HY-13796

IPSU
Orexin Receptor (OX Receptor) Neurological Disease Endocrinology

IPSU is a selective, orally available and brain penetrant OX2R antagonist with a pK_i of 7.85.
HY-100308

SB-568849
MCHR1 (GPR24) Metabolic Disease Endocrinology

SB-568849 is a melanin-concentrating hormone receptor 1 (MCH R1) antagonist with a pK_i of 7.7.

HY-13291

WIN 55,212-2 Mesylate (R)-(+)-WIN 55212	Cannabinoid Receptor	Neurological Disease
WIN 55,212-2 Mesylate is a potent aminoalkylindole cannabinoid (CB) receptor agonist with K_is of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, respectively.

HY-10261

Afatinib BIBW 2992	EGFR Autophagy	Cancer
Afatinib (BIBW 2992) is an irreversible EGFR family inhibitor with IC₅₀s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFR^wt, EGFR^L858R, EGFR^L858R/T790M and HER2, respectively.

HY-135279

CFTR corrector 4	CFTR	Inflammation/Immunology
CFTR corrector 4 (Compound 13), an active (R,R)-form enantiomer, is a highly potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. CFTR corrector 4 can increase CFTR levels at the cell surface and have the potential for treatment of cystic fibrosis.

HY-13106

Olodanrigan EMA401; PD-126055	Angiotensin Receptor	Neurological Disease Endocrinology
Olodanrigan (EMA401) is a highly selective, orally active, peripherally restricted angiotensin II type 2 receptor (AT2R) antagonist. It is under development as a neuropathic pain therapeutic agent. Olodanrigan (EMA401) analgesic action appears to involve inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons.

HY-17457

Levalbuterol tartrate Levosalbutamol tartrate	Adrenergic Receptor	Neurological Disease Endocrinology
Levosalbutamol tartrate(levalbuterol) is the R-enantiomer of the short-acting β2-adrenergic receptor agonist salbutamol.

HY-18697

JD-5037
Cannabinoid Receptor Metabolic Disease Cancer

JD-5037 is a novel, peripherally restricted CB₁R antagonist with an IC₅₀ of 1.5 nM.

HY-101601

Bamirastine TAK-427	Histamine Receptor	Inflammation/Immunology Endocrinology
Bamirastine inhibits ligand binding to recombinant human histamine H₁ receptors (rhH₁R) with an IC₅₀ value of 17.3 nM.

HY-P1531

γ-1-Melanocyte Stimulating Hormone (MSH), amide	Melanocortin Receptor	Metabolic Disease Endocrinology
γ-1-Melanocyte Stimulating Hormone (MSH), amide is a 11-amino acid peptide. γ-1-Melanocyte Stimulating Hormone (MSH) regulates sodium (Na⁺) balance and blood pressure through activation of the melanocortin receptor 3 (MC3-R).

HY-14813

Cutamesine SA4503; AGY 94806	Sigma Receptor	Neurological Disease
Cutamesine (SA4503; AGY-94806) is a selective sigma 1 receptor(σ1R) agonist; high affinity for the sigma 1 receptor subtype labeled by (+)-[3H]pentazocine (IC50= 17.4±1.9 nM); 100-fold less affinity for the sigma 2 receptor.

HY-U00433

JMV 2959
GHSR Neurological Disease Endocrinology

JMV 2959 is a growth hormone secretagogue receptor type 1a (GHS-R_1a) antagonist with an IC₅₀ of 32 nM.
HY-B0794A

AZ7550 hydrochloride
IGF-1R Drug Metabolite Cancer Endocrinology

AZ7550 hydrochloride is an active metabolite of AZD9291 and inhibits the activity of IGF1R with an IC₅₀ of 1.6 μM.

HY-B0392

(S)-(+)-Rolipram (+)-Rolipram; (S)-Rolipram	Phosphodiesterase (PDE) Apoptosis	Inflammation/Immunology Cancer
(S)-(+)-Rolipram is a PDE4-inhibitor and an anti-inflammatory agent, less potent than its R enantiomer.

HY-B0794

AZ7550
IGF-1R Drug Metabolite Cancer Endocrinology

AZ7550 is an active metabolite of AZD9291 and inhibits the activity of IGF1R with an IC₅₀ of 1.6 μM.
HY-15393

VU 0357121
mGluR Neurological Disease

VU0357121 is a novel positive and highly selective allosteric modulator (PAM) of mGlu5R with EC50 of 33 nM.

HY-13820

GSK2656157	PERK Autophagy Apoptosis	Cancer
GSK2656157 is a selective and ATP-competitive inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) with an IC₅₀ of 0.9 nM.

HY-B0794B

AZ7550 Mesylate AZ7550 trimesylate salt	IGF-1R Drug Metabolite	Cancer Endocrinology
AZ7550 Mesylate is an active metabolite of AZD9291 and inhibits the activity of *IGF1R* with an IC₅₀ of 1.6 μM.

HY-101768

PRN1371	FGFR c-Fms	Cancer
PRN1371 is a highly selective and potent FGFR1-4 and *CSF1R* inhibitor with IC₅₀s of 0.6, 1.3, 4.1, 19.3 and 8.1 nM for FGFR1, FGFR2, FGFR3, FGFR4 and CSF1R, respectively.

HY-129657

GLP-1 receptor agonist 4	Glucagon Receptor	Metabolic Disease
GLP-1 receptor agonist 4 is a glucagon-like peptide-1 receptor (GLP-1R) agonist extracted from patent WO2009111700A2, compound 87, has an EC₅₀ of 64.5 nM. GLP-1 receptor agonist 4 can be used in the research for treatment of diabetes.

HY-135680

I-OMe-Tyrphostin AG 538 I-OMe-AG 538	IGF-1R	Cancer Metabolic Disease
I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of *IGF-1R* (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells. I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα), with an IC₅₀ of 1 µM.

HY-125821

Sigma-1 receptor antagonist 1	Sigma Receptor	Neurological Disease
Sigma‑1 receptor antagonist 1 (compound 137) is a potent and selective sigma-1 receptor (σ1R) antagonist, with a high binding affinity to σ1R receptor (K_i = 1.06 nM). Sigma‑1 receptor antagonist 1 exhibits antineuropathic pain activity and acts as a promising agent for the treatment of neuropathic pain.

HY-15772S

Osimertinib D6 AZD-9291 D6; Mereletinib D6	EGFR	Cancer
Osimertinib D6 (AZD-9291 D6) is a deuterium labeled Osimertinib. Osimertinib is an irreversible and mutant selective EGFR inhibitor with IC₅₀s of 12 and 1 nM against EGFR^L858R and EGFR^L858R/T790M, respectively.

HY-133552

RORγt Inverse agonist 10	ROR	Inflammation/Immunology
RORγt Inverse agonist 10 is a potent and orally bioavailable RORγt (retinoic acid receptor-related orphan nuclear receptor gamma t) inverse agonist, with an IC₅₀ of 51 nM. RORγt is a major transcription factor of genes related to psoriasis pathogenesis such as IL-17A, IL-22, and IL-23R

HY-125845A

(S,S,S)-AHPC hydrochloride (S,S,S)-VH032-NH2 hydrochloride	Ligand for E3 Ligase	Cancer
(S,S,S)-AHPC hydrochloride is a von Hippel-Lindau (VHL) amino building block. (S,S,S)-AHPC is a ligand used as a negative control for (S,R,S)-AHPC. (S,R,S)-AHPC is the VH032-based VHL ligand used in the recruitment of the VHL protein.

HY-10346

AV-412
MP412
EGFR Cancer

AV-412 (MP412) is an EGFR inhibitor with IC₅₀s of 0.75, 0.5, 0.79, 2.3, 19 nM for EGFR, EGFR^L858R, EGFR^T790M, EGFR^L858R/T790M and ErbB2, respectively.

HY-P1858

Urocortin III, mouse	CRFR	Neurological Disease Cardiovascular Disease Endocrinology
Urocortin III, mouse is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III preferentially binds and activates *CRF-R2*. Urocortin III (Ucn3) is a known component of the behavioral stress response system. Urocortin III and CRF-R2 in the medial amygdala regulate complex social dynamics.

HY-133780

Afatinib impurity 11	EGFR Autophagy	Cancer
Afatinib impurity 11 is an impurity of Afatinib. Afatinib is an irreversible EGFR family inhibitor with IC₅₀s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFR^wt, EGFR^L858R, EGFR^L858R/T790M and HER2, respectively.

HY-13740

Resiquimod R848; S28463	Toll-like Receptor (TLR) HCV	Inflammation/Immunology Cancer
Resiquimod is a Toll-like receptor 7 and 8 (TLR7/TLR8) agonist that induces the upregulation of cytokines such as TNF-α, IL-6 and IFN-α.

HY-14881

Bedaquiline TMC207; R207910	Bacterial Antibiotic	Infection
Bedaquiline (TMC207) is a diarylquinoline drug and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit. Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-drug resistant tuberculosis.

HY-10562A

Ketanserin tartrate R41468 tartrate	5-HT Receptor Potassium Channel Autophagy	Neurological Disease
Ketanserin tartrate is a selective 5-HT receptor antagonist. Ketanserin tartrate also blocks hERG current (I_hERG) in a concentration-dependent manner (IC₅₀=0.11 μM).

HY-13072

Cenisertib AS-703569; R-763	Aurora Kinase Bcr-Abl Akt STAT FLT3	Cancer
Cenisertib (AS-703569) is a multi-kinase inhibitor that blocks the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5 and FLT3. Cenisertib induces major growth-inhibitory effects by blocking the activity of several different molecular targets in neoplastic mast cells (MC). Cenisertib inhibits tumor growth in xenograft models of pancreatic, breast, colon, ovarian, and lung tumors and leukemia.

HY-18627

PFI-2 (R)-PFI-2	Histone Methyltransferase	Cancer
PFI-2 is a a first-in-class, potent, highly selective, and cell-active inhibitor of the methyltransferase activity of SETD7 with IC50 of 2 nM, 500 fold active than (S)-PFI-2.

HY-10405

Pamapimod Ro4402257; R1503	p38 MAPK Autophagy	Inflammation/Immunology
Pamapimod (Ro4402257) is a potent, selective and orally active p38 MAPK inhibitor with IC₅₀s of 14 nM and 480 nM and K_is of 1.3 nM and 120 nM for p38α and p38β, respectively. Pamapimod has no activity against p38δ or p38γ isoforms. Pamapimod has the potential for rheumatoid arthritis and other autoimmune diseases treatment.

HY-90005

Etravirine
R165335; TMC125
Reverse Transcriptase HIV Infection

Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.

HY-18072

GSK2606414	PERK Autophagy Apoptosis	Cancer
GSK2606414 is a cell-permeable and orally available protein kinase R-like endoplasmic reticulum (ER) kinase (PERK) inhibitor with an IC₅₀ of 0.4 nM.

HY-18082

AGI-5198
IDH-C35
Isocitrate Dehydrogenase (IDH) Cancer

AGI-5198 is a potent and selective mutant IDH1^R132H inhibitor with an IC₅₀ of 0.07 μM.

HY-15243

Capromorelin Tartrate CP 424391-18	GHSR	Neurological Disease Endocrinology
Capromorelin Tartrate is an orally active, potent growth hormone secretagogue receptor (GHSR) agonist, with K_i of 7 nM for hGHS-R1a.

HY-125108

PHPS1 sodium	Phosphatase	Cancer Cardiovascular Disease
PHPS1 sodium is a potent and selective Shp2 inhibitor with K_is of 0.73, 5.8, 10.7, 5.8, and 0.47 μM for Shp2, Shp2-R362K, Shp1, PTP1B, and PTP1B-Q, respectively.

HY-B0793

AZ-5104	EGFR	Cancer
AZ-5104 is an active, demethylated metabolite of AZD 9291. AZ-5104 is an EGFR inhibitor with IC₅₀s of 1, 6, 1, 25 and 7 nM for EGFR^L858R/T790M, EGFR^L858R, EGFR^L861Q, EGFR and ErbB4, respectively.

HY-13203

NVP-TAE 226 TAE226	FAK Pyk2 IGF-1R Insulin Receptor Apoptosis	Cancer Endocrinology
NVP-TAE 226 (TAE226) is a potent and ATP-competitive dual FAK and *IGF-1R* inhibitor with IC₅₀s of 5.5 nM and 140 nM, respectively. NVP-TAE 226 (TAE226) also effectively inhibits Pyk2 and insulin receptor (InsR) with IC₅₀s of 3.5 nM and 44 nM, respectively.

HY-P1858A

Urocortin III, mouse TFA	CRFR	Neurological Disease Cardiovascular Disease Endocrinology
Urocortin III, mouse TFA is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III preferentially binds and activates *CRF-R2*. Urocortin III (Ucn3) is a known component of the behavioral stress response system. Urocortin III and CRF-R2 in the medial amygdala regulate complex social dynamics.

HY-15656A

Ceritinib dihydrochloride LDK378 dihydrochloride	ALK Insulin Receptor IGF-1R	Cancer Endocrinology
Ceritinib dihydrochloride (LDK378 dihydrochloride) is a selective, orally bioavailable and ATP-competitive ALK tyrosine kinase inhibitor with an IC₅₀ of 200 pM. Ceritinib dihydrochloride (LDK378 dihydrochloride) also inhibits *IGF-1R, InsR, and STK22D* with IC₅₀ values of 8, 7, and 23 nM, respectively. Ceritinib dihydrochloride (LDK378 dihydrochloride) shows great antitumor potency.

HY-10253

AG1024 Tyrphostin AG 1024	IGF-1R Insulin Receptor Apoptosis	Cancer Endocrinology
AG1024 (Tyrphostin AG 1024) is a reversible, competitive and selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC₅₀ of 7 μM. AG1024 inhibits phosphorylation of insulin receptor (IR; IC₅₀=57 μM). AG1024 induces apoptosis and has anti-cancer activity.

HY-100213

EAI045	EGFR	Cancer
EAI045 is an allosteric and the fourth-generation inhibitor of mutant EGFR with IC₅₀s of 1.9, 0.019, 0.19 and 0.002 μM for EGFR, EGFR^L858R, EGFR^T790M and EGFR^L858R/T790M at 10 μM ATP, respectively.

HY-15656

Ceritinib LDK378	ALK Insulin Receptor IGF-1R	Cancer Endocrinology
Ceritinib (LDK378) is a selective, orally bioavailable, and ATP-competitive ALK tyrosine kinase inhibitor with an IC₅₀ of 200 pM. Ceritinib (LDK378) also inhibits *IGF-1R, InsR, and STK22D* with IC₅₀ values of 8, 7, and 23 nM, respectively. Ceritinib (LDK378) shows great antitumor potency.

HY-114194

CCR1 antagonist 7
CCR Inflammation/Immunology Endocrinology

CCR1 antagonist 7 (compound 16r) is a chemokine receptor 1 (CCR1) antagonist, with an IC₅₀ of 4 nM.

HY-10252

NVP-ADW742 ADW742; GSK 552602A; ADW	IGF-1R Insulin Receptor Apoptosis	Cancer Endocrinology
NVP-ADW742 (ADW742) is an orally active, selective IGF-1R tyrosine kinase inhibitor with an IC₅₀ of 0.17 μM. NVP-ADW742 inhibits insulin receptor (InsR) with an IC₅₀ of 2.8 μM. NVP-ADW742 induces pleiotropic antiproliferative/proapoptotic biologic sequelae in tumor cells.

HY-112601

IDH1 Inhibitor 1	Isocitrate Dehydrogenase (IDH)	Cancer
IDH1 Inhibitor 1 is a potent, orally bioavailable, brain-penetrant and selective mutant IDH1 inhibitor with IC₅₀s of 0.021 μM, 0.045 μM, and 2.52 μM for IDH1^R132H, IDH1^R132C, and IDH1^WT, respectively. Anticancer activity.

HY-104066

Theliatinib HMPL-309	EGFR	Cancer
Theliatinib (HMPL-309) is a potent, ATP-competitive, orally active and highly selective EGFR inhibitor with a K_i of 0.05 nM and an IC₅₀ of 3 nM. Theliatinib has an IC₅₀ of 22 nM for *EGFR T790M/L858R* mutant. Theliatinib shows >50-fold selectivity for EGFR** than other kinases. Anti-tumor activity.

HY-15292

S107	Others	Cardiovascular Disease
S107 is an orally available, blood brain barrier-permeable compound, which stabilizes RyR2 channels by enhancing the binding of calstabin2 to the mutant Ryr2-R2474S channel. S107 inhibits Ca²⁺ leakage from the sarcoplasmic reticulum (SR) and prevents cardiac arrhythmias and raises the seizure threshold.

HY-N4267

Yangambin	Calcium Channel	Infection Cardiovascular Disease
Yangambin, a furofuran lignan, is already isolated from plants such as member of the Annonaceae family, including species of the genus Rollinia: R. pickeli, R. exalbidaand R. mucosa, as well from the Magnolia biondii. Yangambin, a selective PAF receptor antagonist, inhibits Ca²⁺ influx through voltage-gated Ca²⁺ channels, leading to the reduction in [Ca²⁺]i in vascular smooth muscle cells and consequent peripheral vasodilation. Yangambin exhibits the antiallergic activity against β-hexosaminidase release with an IC₅₀ of 33.8 μM and for anti-inflammatory activity with an IC₅₀ of 37.4 μM.

HY-N0507

Rosavin
Others Neurological Disease

Rosavin is isolated from R. rosea, Rosavin shows antidepressant-like, adaptogenic, anxiolytic-like effects in mice model.
HY-N2084

Perillartine
DL-Perillartine
Endogenous Metabolite Others

Perillartine is a sweetener, which activates the taste receptor type 1 member 2 (Tas1r2) subunit in a species-dependent manner.
HY-135884

PKR activator 2
Pyruvate Kinase Cardiovascular Disease

PKR activator 2 is a potent pyruvate kinase-R (PKR) activator extracted from patent WO2019035863A1, compound 385.

HY-130608

Mutated EGFR-IN-3	EGFR	Cancer
Mutated EGFR-IN-3 (compound 3) is a potent, ATP-competitive and highly selective allosteric dibenzodiazepinone inhibitor of the *EGFR(L858R/T790M)* and *EGFR(L858R/T790M/C797S)* mutants with IC₅₀ values of 12 nM and 13 nM, respectively.

HY-128862

EGFR-IN-7	EGFR	Cancer
EGFR-IN-7 (compound 34) is a selective and potent EGFR kinase inhibitor extracted from patent WO2019015655A1, has IC₅₀s of 7.92 nM and 0.218 nM for EGFR (WT) and EGFR (mutant C797S/T790M/L858R) respectively, and shows anti-tumor activity.

HY-10346A

AV-412 free base MP-412 free base	EGFR	Cancer
AV-412 free base (MP-412 free base) is an EGFR inhibitor with IC₅₀s of 0.75, 0.5, 0.79, 2.3, 19 nM for EGFR, EGFR^L858R, EGFR^T790M, EGFR^L858R/T790M and ErbB2, respectively.

HY-B0244

Praziquantel	Parasite Antibiotic	Infection
Praziquantel is a racemic mixture, which is composed of (R)-Praziquantel and (S)- Praziquantel. Praziquantel is safe and has been used for the research of schistosomiasis.

HY-15748

JNJ-40411813
ADX-71149
mGluR Neurological Disease

JNJ-40411813 (ADX-71149) is a novel positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM.
HY-17004

Olmesartan
RNH-6270
Angiotensin Receptor Cardiovascular Disease

Olmesartan (RNH-6270) is an angiotensin II receptor (AT1R) antagonist used to treat high blood pressure.

HY-14887

Fedovapagon	Vasopressin Receptor	Metabolic Disease
Fedovapagon is a selective vasopressin V2 receptor (V2R) agonist with an EC₅₀ of 24 nM, which is being developed for the treatment of nocturia.

HY-13508

JNJ-7777120	Histamine Receptor	Inflammation/Immunology Endocrinology
JNJ-7777120 is a selective H4R antagonist with Ki of 4 ±1 nM, exhibits >1000-fold selectivity over the other histamin receptors.

HY-10408

Ki20227	c-Fms VEGFR c-Kit PDGFR	Inflammation/Immunology
Ki20227 is an orally active and highly selective c-Fms tyrosine kinase (CSF1R) inhibitor with IC₅₀s of 2 nM, 12 nM, 451 and 217 nM for CSF1R, VEGFR2 (vascular endothelial growth factor receptor-2), c-Kit (stem cell factor receptor) and PDGFRβ (platelet-derived growth factor receptor β). Ki20227 suppresses osteoclast differentiation and osteolytic bone destruction.

HY-114226

Olutasidenib FT-2102	Isocitrate Dehydrogenase (IDH)	Cancer Inflammation/Immunology
Olutasidenib (FT-2102) is a highly potent, orally active, brain penetrant and selective inhibitor of mutant Isocitrate dehydrogenase 1 (IDH1), with IC₅₀ values of 21.2 nM and 114 nM for IDH1- R132H and IDH1- R132C, respectively . Olutasidenib (FT-2102) is under the study in the treatment of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) .

HY-12026

WZ4002
EGFR Cancer

WZ4002 is a mutant selective EGFR inhibitor with IC₅₀s of 2, 8, 3 and 2 nM for EGFR^L858R, EGFR^L858R/T790M, EGFR^E746_A750 and EGFR^{E746_A750/T790M}, respectively.
HY-B1173

(+)-Camphor
D-(+)-Camphor; (1R)-(+)-Camphor
Bacterial Others

(+)-Camphor is an ingredient in cooking, and as an embalming fluid for medicinal purposes,

HY-30237

Seliciclib Roscovitine; CYC202; R-roscovitine	CDK	Cancer
Seliciclib (Roscovitine) is an orally bioavailable and selective CDKs inhibitor with IC₅₀s of 0.2 μM, 0.65 μM, and 0.7 μM for CDK5, Cdc2, and CDK2, respectively.

HY-12170

Prinomastat AG3340; KB-R9896	MMP	Cancer
Prinomastat (AG3340) is a broad spectrum, potent, orally active metalloproteinase (MMP) inhibitor with IC₅₀s of 79, 6.3 and 5.0 nM for MMP-1, MMP-3 and MMP-9, respectively. Prinomastat inhibits MMP-2, MMP-3 and MMP-9 with K_is of 0.05 nM, 0.3 nM and 0.26 nM, respectively. Prinomastat crosses blood-brain barrier. Antitumor avtivity.

HY-100805

D-Glutamic acid
(R)-Glutamic acid
Endogenous Metabolite Neurological Disease

D-glutamic acid, an enantiomer of L- glutamic acid, is widely used in pharmaceuticals and foods.
HY-15811

XMD8-87
ACK1-B19
Tyrosinase Cancer

XMD8-87 is a potent TNK2 inhibitor with IC₅₀ values of 38 and 113 nM for the D163E and R806Q mutations, respectively.
HY-101243

XMD16-5
Tyrosinase Cancer

XMD16-5 is a potent TNK2 inhibitor with IC₅₀ values of 16 and 77 nM for the D163E and R806Q mutations, respectively.

HY-136390

ML417	Dopamine Receptor	Neurological Disease
ML417 is a selective and brain penetrant D3 dopamine receptor (D3R) agonist, with an EC₅₀ of 38 nM. ML417 potently promotes D3R-mediated β-arrestin translocation, G protein mediated signaling, and pERK phosphorylation with minimal effects on other GPCR-mediated signaling. ML417 exhibits neuroprotection against toxin-induced neurodegeneration of dopaminergic neurons.

HY-12001

WZ-3146	EGFR	Cancer
WZ3146 is a mutant selective EGFR inhibitor with IC₅₀s of 2, 2, 5, 14 and 66 nM for EGFR^L858R, EGFR^L858R/T790M, EGFR^E746_A750, EGFR^{E746_A750/T790M} and EGFR, respectively.

HY-16749A

Pexidartinib hydrochloride PLX-3397 hydrochloride	c-Fms c-Kit Apoptosis	Cancer
Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC₅₀s of 20 and 10 nM, respectively. Pexidartinib hydrochloride exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib hydrochloride induces cell apoptosis and has anti-cancer activity.

HY-135883

PKR activator 1
Pyruvate Kinase Cardiovascular Disease

PKR activator 1 is a potent pyruvate kinase-R (PKR) activator extracted from patent WO2019035865A1, compound E7-93.

HY-129946

Dopamine D2 receptor antagonist-1	Dopamine Receptor	Neurological Disease
Dopamine D2 receptor antagonist-1 is a negative allosteric modulator (NAM) of the dopamine D2 receptor (D2R) with sub-mM affinity.

HY-12405

CGP-42112
CGP42112A
Angiotensin Receptor Neurological Disease Endocrinology

CGP-42112 (CGP-42112A) is a potent Angiotensin-II subtype 2 receptor(AT2 R) agonist.

HY-U00433A

JMV 2959 hydrochloride	GHSR	Neurological Disease Endocrinology
JMV 2959 hydrochloride is a growth hormone secretagogue receptor type 1a (GHS-R_1a) antagonist with an IC₅₀ of 32±3 nM in LLC-PK₁ cells.

HY-118930

MK-0493	Melanocortin Receptor	Endocrinology Metabolic Disease
MK-0493 is a potent, orally active and selective agonist of the melanocortin receptor 4 (MC4R), demonstrating significant reductions in energy intake.

HY-15452A

Selisistat S-enantiomer EX-527 (S-enantiomer)	Sirtuin	Cancer
Selisistat S-enantiomer (EX-527 S-enantiomer) is the S-enantiomer of Selisistat, with an IC₅₀ of 123 nM for SIRT1. Selisistat S-enantiomer is much more potent than Selisistat R-enantiomer.

HY-12462

β cell proliferation agonist WS3	Others	Inflammation/Immunology
β cell proliferation agonist WS3 is a novel small molecule that promotes β cell proliferation with EC50 of 28 nM(induced R7T1 proliferation).

HY-128934

Antitumor agent-2
Others Cancer Inflammation/Immunology

Antitumor agent-2 is sourced from patent CN102250203, compound 6a-r, has antitumor action and anti-inflammatory action.

HY-131277

Dehydro Olmesartan	Angiotensin Receptor	Cardiovascular Disease
Dehydro Olmesartan is a derivative of Olmesartan. Olmesartan is an angiotensin II receptor (AT1R) antagonist and has the potential for high blood pressure study.

HY-P1208

PG-931	Melanocortin Receptor	Inflammation/Immunology
PG-931, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC₅₀=0.58 nM) agonist and is more selective than for the hMC3R (IC₅₀=55 nM) or the hMC5R (IC₅₀=2.4 nM). PG-931 can reverse haemorrhagic shock and prevent multiple organ damage in vivo.

HY-10847B

SB-277011 hydrochloride SB-277011A hydrochloride	Dopamine Receptor 5-HT Receptor	Neurological Disease
SB-277011 hydrochloride (SB-277011A hydrochloride) is a potent, selective, orally bioavailable and brain penetrate dopamine D₃ receptor (D₃R) antagonist with K_i values of 10.7 nM and 11.2 nM at rodent and human D₃R, respectively. SB-277011 hydrochloride displays 80- to 100-fold selectivity over other dopamine receptors with pK_is of 8.0, 6.0, <5.2, and 5.9 for D3, D2, 5-HT_1B, and 5-HT_1D receptors, respectively.

HY-115682

(S)-ZINC-3573

(S)-ZINC-3573 is a negative control for (R)-ZINC 3573. (S)-ZINC-3573 displays no activity at MRGPRX2 at concentrations below 100 μM.

HY-U00333

α1 adrenoceptor-MO-1	Adrenergic Receptor	Neurological Disease Endocrinology
α1 adrenoceptor-MO-1, an S enantiomer, has affinity at alpha 1 adrenergic receptor, shows alphalytic activity, and possesses analgesic action; more active than R enantiomer.

HY-P0201

Substance P Neurokinin P	Neurokinin Receptor Endogenous Metabolite	Neurological Disease Endocrinology
Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, *NK1R*).

HY-12195

ABT-239	Histamine Receptor TRP Channel	Neurological Disease Endocrinology
ABT-239 is a novel, highly efficacious, non-imidazole class of *H3R* antagonist and a transient receptor potential vanilloid type 1 (TRPV1) antagonist.

HY-110123

ML-00253764 hydrochloride	Melanocortin Receptor	Cancer Endocrinology
ML-00253764 is a nonpeptidic melanocortin receptor 4 (MC4R) antagonist with a K_i and IC₅₀ of 0.16 µM and 0.103 µM, respectively. Brain penetrant.

HY-131276

Olmesartan lactone impurity	Angiotensin Receptor	Cardiovascular Disease
Olmesartan lactone impurity is a cyclic ester impurity of Olmesartan. Olmesartan is an angiotensin II receptor (AT1R) antagonist and has the potential for high blood pressure study.

HY-131274

Fexofenadine Impurity F	Others	Others
Fexofenadine Impurity F is the impurity of Fexofenadine. Fexofenadine, a *H1R* antagonist, is an anti-allergic agent used in seasonal allergic rhinitis and chronic idiopathic urticarial.

HY-10013

Taranabant MK-0364	Cannabinoid Receptor	Metabolic Disease
Taranabant is a highly potent and selective cannabinoid 1 (CB1) receptor inverse agonist that inhibits the binding and functional activity of various agonists, with a binding K_i of 0.13 nM for the human CB1R in vitro.

HY-131279

Olmesartan ethyl ester	Others	Others
Olmesartan ethyl ester (compound 11) is an Olmesartan impurity. Olmesartan (RNH-6270) is an angiotensin II receptor (AT1R) antagonist used to in the high blood pressure study.

HY-P1208A

PG-931 TFA	Melanocortin Receptor	Inflammation/Immunology
PG-931 TFA, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC₅₀=0.58 nM) agonist and is more selective than for the hMC3R (IC₅₀=55 nM) or the hMC5R(IC₅₀=2.4 nM). PG-931 TFA can reverse haemorrhagic shock and prevent multiple organ damage in vivo.

HY-113846

CMP-5 hydrochloride	Histone Methyltransferase	Cancer
CMP-5 hydrochloride is a potent, specific, and selective PRMT5 inhibitor, while displays no activity against PRMT1, PRMT4, and PRMT7 enzymes. CMP-5 hydrochloride selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations. CMP-5 hydrochloride prevents EBV-driven B-lymphocyte transformation but leaving normal B cells unaffected.

HY-116624

MAZ51	VEGFR Apoptosis	Cancer
MAZ51 is a selective inhibitor of VEGFR-3 (Flt-4) tyrosine kinase. MAZ51 inhibits VEGF-C-induced activation of VEGFR-3 without blocking VEGF-C-mediated stimulation of VEGFR2. MAZ51 had no effect on ligand-induced autophosphorylation of EGFR, IGF-1R and PDGFRβ. MAZ51 blocks proliferation and induces apoptosis in a wide variety of tumor cells. Antitumor activity.

HY-16749

Pexidartinib PLX-3397	c-Fms c-Kit Apoptosis	Cancer
Pexidartinib (PLX-3397) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC₅₀s of 20 and 10 nM, respectively. Pexidartinib (PLX-3397) exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib (PLX-3397) induces cell apoptosis and has anti-tumor activity.

HY-18627A

PFI-2 hydrochloride (R)-PFI-2 hydrochloride	Histone Methyltransferase	Cancer
PFI-2 hydrochloride is a a first-in-class, potent, highly selective, and cell-active inhibitor of the methyltransferase activity of SETD7 with IC50 of 2 nM, 500 fold active than (S)-PFI-2.

HY-111095

D-(-)-Lactic acid (R)-2-Hydroxypropionic acid	Endogenous Metabolite	Metabolic Disease
D-(-)-Lactic acid is a normal intermediate in the fermentation (oxidation, metabolism) of sugar. D-(-)-Lactic acid is identified to be a competitive inhibitor of ProDH (proline dehydrogenase) in plants.

HY-P0165

Taspoglutide ITM077; R1583; BIM51077	Glucagon Receptor	Metabolic Disease
Taspoglutide is a long-acting glucagon-like peptide 1 (GLP-1) receptor agonist developed for treatment of type 2 diabetes, with an EC₅₀ value of 0.06 nM. Sequence: His-{Aib}-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-{Aib}-Arg-NH2.

HY-12707

Piribedil	Adrenergic Receptor Dopamine Receptor	Neurological Disease Endocrinology
Piribedil is a dopamine D₂ receptor (D₂R) agonist which also displays antagonist property at hα_1A-adrenoceptor (hα_1A-AR).

HY-B0596

Taltirelin TA-0910	Thyroid Hormone Receptor	Neurological Disease Endocrinology
Taltirelin (TA0910) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC₅₀ of 910 nM and EC₅₀ of 36 nM for stimulating an increase in cytosolic Ca²⁺ concentration (Ca²⁺ release).

HY-13493

AC710
PDGFR c-Kit FLT3 Cancer

AC710 is a potent PDGFR inhibitor with K_ds of 0.6, 1.57, 1, 1.3, 1.0 nM for FLT3, CSF1R, KIT, PDGFRα and PDGFRβ, respectively.

HY-100742

GNE-140 racemate	Lactate Dehydrogenase	Cancer
GNE-140 racemate is a racemate mixture of (R)-GNE-140 and (S)-GNE-140. GNE-140 racemate is a potent lactate dehydrogenase A (LDHA) inhibitor.

HY-17004S

Olmesartan D4 RNH-6270 D4	Angiotensin Receptor	Cardiovascular Disease
Olmesartan D4 (RNH-6270 D4) is the deuterium labeled Olmesartan. Olmesartan is an angiotensin II receptor (AT1R) antagonist used to treat high blood pressure.

HY-133775

Olmesartan impurity	Angiotensin Receptor	Metabolic Disease
Olmesartan impurity is an Olmesartan impurity. Olmesartan (RNH-6270) is an angiotensin II receptor (AT1R) antagonist has the potential for high blood pressure study.

HY-13493A

AC710 Mesylate
PDGFR Cancer

AC710 Mesylate is a potent PDGFR inhibitor with K_ds of 0.6, 1.57, 1, 1.3, 1.0 nM for FLT3, CSF1R, KIT, PDGFRα and PDGFRβ, respectively.

HY-B0801A

Fexofenadine hydrochloride MDL-16455 hydrochloride; Terfenadine carboxylate hydrochloride	Histamine Receptor	Inflammation/Immunology Endocrinology
Fexofenadine hydrochloride (MDL-16455 hydrochloride), a *H1R* antagonist, is an anti-allergic agent used in seasonal allergic rhinitis and chronic idiopathic urticarial (person aged ≥16 years).

HY-125819

Sigma-1 receptor antagonist 2	Sigma Receptor	Neurological Disease
Sigma-1 receptor antagonist 2 is a potent and selective sigma 1 receptor (σ1 R) antagonist with K_is of 3.88 and 1288 nM for σ1 and σ2 receptor, respectively.

HY-B0596A

Taltirelin acetate TA-0910 acetate	Thyroid Hormone Receptor	Neurological Disease Endocrinology
Taltirelin acetate (TA-0910 acetate) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC₅₀ of 910 nM and EC₅₀ of 36 nM for stimulating an increase in cytosolic Ca²⁺ concentration (Ca²⁺ release).

HY-B0751

Fumagillin Amebacilin; NSC9168	Parasite HIV Antibiotic	Infection
Fumagillin(NSC9168) is a complex biomolecule and used as an antimicrobial agent. Fumagillin can inhibits HIV‐1 infection through the inhibition of HIV-1 viral protein R (Vpr) activity.

HY-12461

WS6
Others Inflammation/Immunology

WS6 is a novel small molecule that promotes β cell proliferation in rodent and human primary islets with EC50 of 0.28 uM(R7T1 cell viability).

HY-120137

CMP-5	Histone Methyltransferase	Cancer
CMP-5 is a potent, specific, and selective PRMT5 inhibitor, while displays no activity against PRMT1, PRMT4, and PRMT7 enzymes. CMP-5 selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations. CMP-5 prevents Epstein-Barr virus (EBV)-driven B-lymphocyte transformation but leaving normal B cells unaffected.

HY-135805

JBJ-04-125-02	EGFR	Cancer
JBJ-04-125-02 is a potent, mutant-selective, allosteric and orally active EGFR inhibitor with an IC₅₀ of 0.26 nM for EGFR^L858R/T790M. JBJ-04-125-02 can inhibit cancer cell proliferation and EGFR^{L858R/T790M/C797S} signaling. JBJ-04-125-02 has anti-tumor activities.

HY-19617A

EGFR-IN-1 hydrochloride	EGFR	Cancer
EGFR-IN-1 hydrochloride is an orally active and irreversible L858R/T790M mutant selective EGFR inhibitor. EGFR-IN-1 hydrochloride potently inhibits Gefitinib-resistant EGFR L858R, T790M with 100-fold selectivity over wild-type EGFR. EGFR-IN-1 hydrochloride displays strong antiproliferative activity against the H1975 cells and the first line mutant HCC827 cells. Antitumor activity.

HY-19617

EGFR-IN-1	EGFR	Cancer
EGFR-IN-1 (compound 24) is an orally active and irreversible L858R/T790M mutant selective EGFR inhibitor. EGFR-IN-1 potently inhibits Gefitinib-resistant EGFR L858R, T790M with 100-fold selectivity over wild-type EGFR. EGFR-IN-1 displays strong antiproliferative activity against the H1975 cells and the first line mutant HCC827 cells. Antitumor activity.

HY-14200

(S)-Rasagiline TVP1022; S-PAI	Monoamine Oxidase	Neurological Disease
(S)-Rasagiline (TVP1022) is the S-isomer of Rasagiline, which is an anti-Parkinson drug, appears to have the same neuroprotective activity as the R-isomer, but is 1000-fold less active as an MAO-B inhibitor.

HY-10622

PF-00446687
Melanocortin Receptor Endocrinology

PF-00446687 is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 ± 1 nM. Pf-446687 is brain penetrant.

HY-12297

Sulfatinib HMPL-012	FGFR VEGFR	Cancer
Sulfatinib (HMPL-012) is a potent and highly selective tyrosine kinase inhibitor against VEGFR1/2/3, FGFR1 and *CSF1R* with IC₅₀s of in a range of 1 to 24 nM.

HY-13984

Mutant EGFR inhibitor	EGFR	Cancer
Mutant EGFR inhibitor is a potent and selective mutant EGFR inhibitor extracted from patent WO 2013014448 A1; inhibits EGFR^L858R, EGFR^{Exon 19 deletion} and EGFR^T790M.

HY-14200A

(S)-Rasagiline mesylate TVP1022 (mesylate); S-PAI mesylate	Monoamine Oxidase	Neurological Disease
(S)-Rasagiline (TVP1022) mesylate is the S-isomer of rasagiline, which is an anti-Parkinson drug, appears to have the same neuroprotective activity as the R-isomer, but is 1000-fold less active as an MAO-B inhibitor.

HY-78869

Mutated EGFR-IN-1 Osimertinib analog	EGFR	Cancer
Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant and T790M resistance mutant.

HY-124733A

LIT-001	Oxytocin Receptor	Neurological Disease
LIT-001 is the first nonpeptide oxytocin receptor (OT-R) agonist (EC₅₀=55 nM; K_i=226 nM). LIT-001 improves social interaction in a mouse model of autism.

HY-103178

MRE3008F20	Adenosine Receptor	Cancer
MRE3008F20 is a highly potent and selective antagonist of adenosine A3 receptor (AA3R), inhibiting agonist-induced cAMP elevation in resting T lymphocytes with an IC₅₀ of 5 nM.

HY-122872

MKK7-COV-9	p38 MAPK	Cancer
MKK7-COV-9 is a potent and selective covalent inhibitor of MKK7 and targets a specific protein–protein interaction of MKK7. MKK7-COV-9 blocks primary B cell activation in response to LPS with an EC₅₀ of 4.98 μM.

HY-19617B

EGFR-IN-1 TFA	EGFR	Cancer
EGFR-IN-1 TFA is an orally active and irreversible L858R/T790M mutant selective EGFR inhibitor. EGFR-IN-1 TFA potently inhibits Gefitinib-resistant EGFR L858R, T790M with 100-fold selectivity over wild-type EGFR. EGFR-IN-1 TFA displays strong antiproliferative activity against the H1975 cells and the first line mutant HCC827 cells. Antitumor activity.

HY-122575

Aurintricarboxylic acid	P2X Receptor Influenza Virus Topoisomerase	Infection Inflammation/Immunology Neurological Disease
Aurintricarboxylic acid is a nanomolar-potency, allosteric antagonist with selectivity towards αβ-methylene-ATP-sensitive P2X1Rs and P2X3Rs, with IC₅₀s of 8.6 nM and 72.9 nM for rP2X1R and rP2X3R, respectively. Aurintricarboxylic acid is a potent anti-influenza agent by directly inhibiting the neuraminidase. Aurintricarboxylic acid is an inhibitor of topoisomerase II and apoptosis. Aurintricarboxylic acid is a selective inhibitor of the TWEAK-Fn14 signaling pathway.

HY-P2161

TAK-683	Others	Cancer
TAK-683 is a potent full KISS1 receptor (KISS1R) agonist (IC₅₀=170 pM) with improved metabolic stability. TAK-683 is a nonapeptide metastin analog, exhibits agonistic activities to KISS1R with EC₅₀ values of 0.96 nM and 1.6 nM for human and rat, respectively. TAK-683 depletes GnRH in the hypothalamus and reduces plasma FSH, LH, and testosterone levels in vivo, it has the potential for the study of hormone-dependent prostate cancer.

HY-42068

(-)-Aspartic acid
(R)-Aspartic acid; D-(-)-Aspartic acid
Endogenous Metabolite iGluR Neurological Disease

(-)-Aspartic acid is an endogenous NMDA receptor agonist.

HY-107661

Arundic Acid ONO-2506; (R)-2-Propyloctanoic acid	Others	Neurological Disease
Arundic acid (ONO-2506) is an astrocyte-modulating agent, which delays the expansion of cerebral infarcts by modulating the activation of astrocytes through inhibition of S-100β synthesis. Arundic acid (ONO-2506) has been developed as a therapeutic agent for stroke and Alzheimer’s disease.

HY-19654B

(-)-GSK598809
1S,5R-GSK598809
Dopamine Receptor Others

(-)-GSK598809 is an isomer of GSK598809. GSK598809 is a potent and selective dopamine D3 Receptor (DRD3) antagonist.

HY-B1950

Quizalofop-p-ethyl (R)-Quizalofop ethyl; Quinofop-ethyl	Others	Others
Quizalofop-P-ethyl is a slightly toxic, selective, postemergence phenoxy herbicide, used to control annual and perennial grass weeds in potatoes, soybeans, sugar beets, peanuts vegetables, cotton and flax. Quizalofop-P-ethyl is absorbed from the leaf surface and is moved throughout the plant. Quizalofop-P-ethyl accumulates in the active growing regions of stems and roots.

HY-N1459

Campesterol
(24R)-5-Ergosten-3β-ol
Endogenous Metabolite Cancer

Campesterol is a plant sterol with cholesterol lowering and anticarcinogenic effects.

HY-Y0152

Cinchonine (8R,9S)-Cinchonine; LA40221	Apoptosis Parasite	Cancer
Cinchonine is a natural compound present in Cinchona bark. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells.

HY-12772S

Hydroxy Itraconazole D8 R-63373 D8	Fungal	Others
Hydroxy Itraconazole D8 is the deuterium labeled Hydroxy Itraconazole. Hydroxy Itraconazole is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.

HY-32343

Secalciferol (24R)-24,25-Dihydroxyvitamin D3	VD/VDR Endogenous Metabolite	Inflammation/Immunology
Secalciferol is a metabolite of Vitamin D, a possibly anti-inflammatory steroid which is involved in bone ossification.

HY-109043

Solriamfetol JZP-110; ADX-N05; R228060	Dopamine Receptor	Neurological Disease
Solriamfetol (JZP-110) is an orally active and selective dopamine and norepinephrine reuptake inhibitor with IC₅₀s of 2.9 μM and 4.4 μM for dopamine and norepinephrine transporters, respectively. Solriamfetol has robust wake-promoting effects.

HY-128720

Diethyl oxalpropionate	Endogenous Metabolite	Metabolic Disease
Diethyl oxalpropionate is an intermediate for poly((R,S)-3,3-dimethylmalic acid) (PDMMLA) derivative synthesis. PDMMLA derivative can be used in synthesis of nanoparticles and study of warfarin encapsulation and controlled release.

HY-114410

CCI-006	Mitochondrial Metabolism	Cancer
CCI-006 is a selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells, by inhibits mitochondrial respiration resulting in insurmountable mitochondrial depolarization and a pro-apoptotic unfolded protein response (UPR) in a subset of MLL-r leukemia cells.

HY-103032

Multi-kinase inhibitor 1	PDGFR c-Kit Bcr-Abl	Cancer
Multi-kinase inhibitor 1 is a potent multi-kinase inhibitor. Multi-kinase inhibitor 1 has the potential for diseases or disorders associated with abnormal or deregulated tyrosine kinase activity, particularly diseases associated with the activity of *PDGF-R, c-Kit* and Bcr-abl.

HY-100657

meta-Fexofenadine meta-MDL-16455; meta-Terfenadine carboxylate	Others	Inflammation/Immunology
meta-Fexofenadine (meta-MDL-16455) is an impurity of Fexofenadine. Fexofenadine, a H1R antagonist, is an anti-allergic agent used in seasonal allergic rhinitis and chronic idiopathic urticarial.

HY-135914

JBJ-02-112-05
EGFR Cancer

JBJ-02-112-05 is a potent, mutant-selective, allosteric and orally active EGFR inhibitor with an IC₅₀ of 15 nM for EGFR^L858R/T790M.

HY-N3199

Neorauflavene	Bacterial	Infection
Neorauflavene is a phenolic neorautanenia isoflavanoid isolated from Neorautanenia edulis. Neorauflavene shows antibacterial activities against *E. faecalis, S. suis, S. agalactiae, P. aeruginosa, B. subtilis, and R. anatipestifer*.

HY-N2000

Bellidifolin	HIV	Cancer Infection Inflammation/Immunology
Bellidifolin is a xanthone isolated from the stems of Swertia punicea, with hepatoprotective, hypoglycemic, anti-oxidation, anti-inflammatory and antitumor activities. Bellidifolin also acts as a viral protein R (Vpr) inhibitor.

HY-N2566

Euscaphic acid	DNA/RNA Synthesis PI3K Apoptosis	Cancer
Euscaphic acid, a DNA polymerase inhibitor, is a triterpene from the root of the R. alceaefolius Poir. Euscaphic inhibits calf DNA polymerase α (pol α) and rat DNA polymerase β (pol β) with IC₅₀ values of 61 and 108 μM. Euscaphic acid induces apoptosis.

HY-116474

Viridicatol	Fungal	Infection
Viridicatol, a quinolinone alkaloid, is isolated from the fermentation of an endophytic fungus Penicillium sp. R22 in Nerium indicum. Viridicatol has strong antifungal activity against Staphylococcus aureus with MIC value of 15.6 μg/mL.

HY-130248

BAY-899	Others	Endocrinology
BAY-899 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist with IC₅₀s of 185 nM and 46nM for hLH (human LH) and rLH (rat LH), respectively. BAY-899 can reduce sex hormone levels.

HY-11083

GW-803430 GW-3430	MCHR1 (GPR24)	Metabolic Disease
GW-803430 (GW-3430) is a potent and selective melanin-concentrating hormone receptor 1 (MCH R1) antagonist with a pIC₅₀ of 9.3. GW-803430 is orally active in an animal model of obesity.

HY-12686

5Z-7-Oxozeaenol FR148083; L783279; LL-Z 1640-2	MAP3K VEGFR	Infection Inflammation/Immunology
5Z-7-Oxozeaenol is a natural anti-protozoan compound from fungal origin, acting as a potent irreversible and selective inhibitor of TAK1 and *VEGF-R2, with IC₅₀*s of 8 nM and 52 nM, respectively.

HY-W016087

Monoethyl pimelate	PROTAC Linker	Cancer
Monoethyl pimelate is a PROTAC linker, which refers to the alkyl/ether composition. Monoethyl pimelate can be used in the synthesis of (S,R,S)-AHPC-Me-C7 ester, a specific BCL-X_L PROTAC degrader.

HY-129997

Luteolinidin chloride	Others	Inflammation/Immunology
Luteolinidin is a natural deoxyanthocyanidin, isolated from mosses and ferns. Luteolinidin is a potent CD38 inhibitor which can protect the heart against I/R injury with preservation of eNOS function and prevention of endothelial dysfunction in vivo.

HY-124733

LIT-001 free base	Oxytocin Receptor	Neurological Disease
LIT-001 free base is the first nonpeptide oxytocin receptor (OT-R) agonist (EC₅₀=55 nM; K_i=226 nM). LIT-001 free base improves social interaction in a mouse model of autism.

HY-112140

JH-VIII-157-02	ALK	Cancer
JH-VIII-157-02 is a structural analogue of alectinib, acts as an ALK inhibitor, and shows an IC₅₀ of 2 nM for echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) G1202R in cells.

HY-15734

AGI-6780	Isocitrate Dehydrogenase (IDH)	Cancer
AGI-6780 that potently and selectively inhibits the tumor-associated mutant IDH2^R140Q with IC₅₀ of 23±1.7 nM. AGI-6780 is less potent against IDH2^WT with IC₅₀ of 190±8.1 nM.

HY-N1353

Rhamnocitrin	Others	Inflammation/Immunology Cardiovascular Disease
Rhamnocitrin is a flavonoid isolated from astragalus complanatus R. Br. (Sha-yuan-zi). Rhamnocitrin is a scavenger of DPPH with an IC₅₀ of 28.38 mM. Rhamnocitrin has anti-oxidant, anti-inflammatory and an-tiatherosclerosis activity.

HY-110066

(Z)-Guggulsterone	Apoptosis VEGFR Akt	Cancer
Z-guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the *VEGF–VEGF-R2–Akt* signaling axis.

HY-14886

Fasitibant chloride MEN16132 free base	Bradykinin Receptor	Neurological Disease Cardiovascular Disease
Fasitibant chloride (MEN16132 free base) is a potent and selective nonpeptide bradykinin B2 receptor (B2R) antagonist. Fasitibant chloride reduces joint pain and diminishes joint oedema in Carrageenan-induced arthritis rat model.

HY-B0927

Hydrastine
(-)-β-Hydrastine; (1R,9S)-β-Hydrastine
Others Others

Hydrastine is a natural alkaloid which is present in Hydrastis canadensis and other plants of the ranunculaceae family.

HY-10238

Danoprevir ITMN-191; R7227; RO5190591; RG7227	HCV Protease HCV	Infection
Danoprevir (ITMN-191) is an orally active NS3/4A protease inhibitor for hepatitis C virus (HCV) with an IC₅₀ of 0.29 nM and is selective for NS3/4A over a panel of 53 proteases (IC₅₀ higher than 10 μM). Danoprevir (ITMN-191) inhibits HCV genotypes 1a, 1b, 4, 5, and 6 (IC₅₀s=0.2-0.4 nM) as well as 2b and 3a (IC₅₀s=1.6, 3.5 nM).

HY-B1194

Tetramisole hydrochloride (±)-Tetramisole hydrochloride; DL-Tetramisole hydrochloride; R-829	Parasite Phosphatase Antibiotic	Infection
Tetramisole hydrochloride is an inhibitor of alkaline phosphatases, is a high purity antiparasitic.

HY-12170A

Prinomastat hydrochloride AG3340 hydrochloride; KB-R9896 hydrochloride	MMP	Cancer
Prinomastat hydrochloride (AG3340 hydrochloride) is a broad spectrum, potent, orally active metalloproteinase (MMP) inhibitor with IC₅₀s of 79, 6.3 and 5.0 nM for MMP-1, MMP-3 and MMP-9, respectively. Prinomastat hydrochloride inhibits MMP-2, MMP-3 and MMP-9 with K_is of 0.05 nM, 0.3 nM and 0.26 nM, respectively. Prinomastat hydrochloride can cross blood-brain barrier. Antitumor avtivity.

HY-I1060

L-Alloisoleucine (3R)-LS-Isoleucine; L-Allo-isoleucine	Endogenous Metabolite	Others
L-Alloisoleucine is a branched chain amino acid and is a stereo-isomer of L-isoleucine. L-Alloisoleucine is a common constituent of human plasma (albeit at low levels).

HY-P0122

iRGD peptide c(CRGDKGPDC)	Integrin	Cancer
iRGD peptide is a 9-amino acid cyclic peptide, triggers tissue penetration of drugs by first binding to av integrins, then proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1, and has tumor-targeting and tumor-penetrating properties.

HY-112950

RET-IN-1	RET	Cancer
RET-IN-1 is a RET kinase inhibitor extracted from patent WO2018071447A1, Compound Example 552, has IC_50s of 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively .

HY-P0049

Argipressin Vasopressin; Arg8-vasopressin; AVP	Vasopressin Receptor	Neurological Disease
Argipressin binds to the V1, V2, V3-vascular arginine vasopressin receptor, with a K_d value of 1.31 nM in A7r5 rat aortic smooth muscle cells for V1. Argipressin is a selective V2 agonist.

HY-B2078A

Eprazinone dihydrochloride	Neurokinin Receptor	Inflammation/Immunology
Eprazinone dihydrochloride is a gent with mucolytic, secretolytic, antitussive, and bronchial antispasmodic properties. Eprazinone dihydrochloride is a neurokinin 1 receptor (NK1R) ligand. Eprazinone dihydrochloride has the potential for chronic bronchitis treatment that improved pulmonary function and arterial partial pressure of oxygen.

HY-114153

PLX5622	c-Fms	Neurological Disease
PLX5622 is a highly selective brain penetrant and oral active *CSF1R* inhibitor with an K_i of 5.9 nM, for extended and specific microglial elimination, preceding and during pathology development. PLX5622 demonstrates desirable PK properties in varies animals.

HY-15729

Rociletinib CO-1686; AVL-301; CNX-419	EGFR	Cancer
Rociletinib (CO-1686) is an orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M, and the K_i values for EGFRL858R/T790M and EGFRWT are 21.5 nM and 303.3 nM, respectively.

HY-112653A

(±)8-HETE	Endogenous Metabolite
(±)8-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid (HY-109590). The biological activity of (±)8-HETE is likely to resemble that of its constituent enantiomers (8(R)-HETE and 8(S)-HETE).

HY-44234A

Fmoc-Gly-Gly-D-Phe-OtBu	ADC Linker	Cancer
Fmoc-Gly-Gly-D-Phe-OtBu is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Gly-Gly-D-Phe-OtBu is the R-isomer of Fmoc-Gly-Gly-Phe-OtBu (HY-44234).

HY-128860

Mutated EGFR-IN-2	EGFR	Cancer
Mutated EGFR-IN-2 (compound 91) is a mutant-selective EGFR inhibitor extracted from patent WO2017036263A1, which potently inhibits single-mutant EGFR (T790M) and double-mutant EGFR (including L858R/T790M (IC₅₀=＜1nM) and ex19del/T790M), and can suppress activity of single gain-of-function mutant EGFR (including L858R and ex19del) as well. Mutated EGFR-IN-2 shows anti-tumor antivity.

HY-P1074

SNX-482	Calcium Channel	Neurological Disease
SNX-482, a peptidyl toxin of the spider Hysterocrates gigas, is a potent, high affinity, selective and voltage-dependent R-type Ca_V2.3 channel blocker with an IC₅₀ of 30 nM. SNX-482 has antinociceptive effect.

HY-128856

P7C3-OMe	Others	Neurological Disease
P7C3-OMe is a pro-neurogenic compound, has therapeutic benefits in neuropsychiatric and/or neurodegenerative disease. The R-enantiomer of P7C3-OMe is far more active than the S-enantiomer.

HY-128579

DW14800	Histone Methyltransferase	Cancer
DW14800 is a protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC₅₀ of 17 nM. DW14800 reduces H4R3me2s levels and enhances the transcription of HNF4α, but does not alter PRMT5 expression. Anti-cancer activity.

HY-15729A

Rociletinib hydrobromide CO-1686 (hydrobromide); AVL-301 hydrobromide; CNX-419 hydrobromide	EGFR	Cancer
Rociletinib hydrobromide (CO-1686 hydrobromide) is an orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M, and the K_i values for EGFRL858R/T790M and EGFRWT are 21.5 nM and 303.3 nM, respectively.

HY-114153A

PLX5622 hemifumarate	c-Fms	Neurological Disease
PLX5622 hemifumarate is a highly selective brain penetrant and orally active *CSF1R* inhibitor with an K_i of 5.9 nM, for extended and specific microglial elimination, preceding and during pathology development. PLX5622 hemifumarate demonstrates desirable PK properties in varies animals.

HY-130249

BAY-298	Others	Endocrinology
BAY-298 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist with IC₅₀s of 96 nM, 23 nM and 78 nM for hLH (human LH) and rLH (rat LH) and cLH (cynomolgus monkey LH), respectively. BAY-298 can reduce sex hormone levels.

HY-103061

Dehydro-ZINC39395747	Others	Cardiovascular Disease
Dehydro-ZINC39395747 is a derivative of ZINC39395747. ZINC39395747 is a potent cytochrome b5 reductase 3 (CYB5R3) inhibitor with an IC₅₀ of 9.14 μM and a K_d of 1.11 μM. ZINC39395747 can increase NO bioavailability in vascular cells.

HY-10502A

Tipifarnib S enantiomer (S)-(-)-R-115777; IND-58359 S enantiomer	Farnesyl Transferase	Cancer
Tipifarnib S enantiomer is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific farnesyltransferase (FTase) inhibitor with IC₅₀ of 0.6 nM. Tipifarnib S enantiomer is the less active isomer.

HY-107608

Leukotriene B4
LTB4; 5(S),12(R)-DiHETE
PROTAC Linker Endogenous Metabolite Cancer

Leukotriene B4 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-13406

TAK-779 Takeda 779	CCR HIV CXCR	Infection Inflammation/Immunology Endocrinology
TAK-779 is a potent and selective nonpeptide antagonist of CCR5 and CXCR3, with a K_i of 1.1 nM for CCR5, and effectively and selectively inhibits R5 HIV-1, with EC₅₀ and EC₉₀ of 1.2 nM and 5.7 nM, respectively, in MAGI-CCR5 cells.

HY-W009724

2-Aminoethyl diphenylborinate 2-APB	Calcium Channel TRP Channel	Infection
2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of *IP3R. 2-Aminoethyl diphenylborinate also inhibits the store-operated Ca²⁺ (SOC)* channel and activates some TRP channels (V1, V2 and V3).

HY-18213

EGFR-IN-9	EGFR	Cancer
EGFR-IN-9 (Compound 8) is a potent EGFR kinase inhibitor with IC₅₀s of 7 nM, 28 nM for the wild type EGFR kinase and double mutant EGFR kinase (L858R/T790M). EGFR-IN-9 has antitumor activity.

HY-125773

β-cyano-L-Alanine Beta-cyano-l-alanine	Others	Neurological Disease
β-cyano-L-Alanine (Beta-cyano-l-alanine), a nitrile of widespread occurrence in higher plants, is enzymatically produced by cyanoalanine synthase from cyanide and cysteine as substrates. β-cyano-L-Alanine abolishes the protective effect of ethanol on cerebral ischemia/reperfusion (I/R) injury.

HY-18750

Zorifertinib AZD3759	EGFR	Cancer
Zorifertinib (AZD3759) is a potent, orally active, central nervous system-penetrant, EGFR inhibitor. At K_m ATP concentrations, the IC₅₀s are 0.3, 0.2, and 0.2 nM for EGFR^wt, EGFR^L858R, and EGFR^{exon 19Del}, respectively.

HY-128778

DBPR112	EGFR	Cancer
DBPR112 (compound 78) is an orally active Furanopyrimidine-Based Epidermal Growth Factor Receptor inhibitor with IC₅₀s of 15 nM and 48 nM for EGFR^WT and EGFR^L858R/T790M, respectively. DBPR112 has significant antitumor efficacy.

HY-130613

MAC-545496	Bacterial	Infection
MAC-545496 is a nanomolar inhibitor of glycopeptide-resistance-associated protein R (GraR). MAC-545496 displays strong binding affinity to the full-length GraR protein (K_d ≤ 0.1 nM). MAC-545496 is an antivirulence agent that reverses β-lactam resistance in Methicillin-resistant strains (MRSA).

HY-12752

Alimemazine Trimeprazine	Others	Inflammation/Immunology Neurological Disease
Alimemazine is a phenothiazine derivative that is generally used as an antipruritic agent and also a hemagglutinin (HA)-receptor antagonist.Alimemazine (Trimeprazine) is also acts as a partial agonist against the histamine H1 receptor (H1R) and other GPCRs. Alimemazine displays sedative, antiserotonin, antispasmodic, and antiemetic properties.

HY-P2141

TRV-120027	Angiotensin Receptor	Cardiovascular Disease
TRV120027, a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R), engages ß-arrestins while blocking G-protein signaling. TRV120027 induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R–β-arrestin-1–TRPC3–PLCγ at the plasma membrane. TRV120027 inhibits angiotensin II–mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 has the potential for the acute decompensated heart failure (ADHF) treatment.

HY-119944

JND3229	EGFR	Cancer
JND3229 is a highly potent and fourth-generation EGFR^C797S reversible inhibitor with IC₅₀ value of 5.8 nM, and also potently suppressed EGFR^L858R/T790M and EGFR^WT with IC₅₀ values of 30.5 and 6.8 nM.

HY-W033577

Tricarbonyldichlororuthenium(II) dimer CORM-2	Others	Inflammation/Immunology
Tricarbonyldichlororuthenium(II) dimer is a pharmacological donor of CO releasing. CO releases from Tricarbonyldichlororuthenium(II) dimer prevents gastric mucosal oxidative damage induced by ischemia/reperfusion (I/R) improving gastric blood flow (GBF), decreasing DNA oxidation and inflammatory response on systemic level.

HY-108669

AZ10606120 dihydrochloride	P2X Receptor	Cancer Neurological Disease
AZ10606120 dihydrochloride is a selective, high affinity antagonist for P2X7 receptor (P2X7R) at human and rat with an IC₅₀ of ~10 nM. AZ10606120 dihydrochloride is little or no effect at other P2XR subtypes. AZ10606120 dihydrochloride has anti-depressant effects and reduces tumour growth.

HY-106224

Orexin A (human, rat, mouse)	Orexin Receptor (OX Receptor)	Neurological Disease
Orexin A human, rat, mouse, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A human, rat, mouse is a specific, high-affinity agonist for G-protein-coupled receptor *OX1R*. Orexin A human, rat, mouse has a role in the regulation of feeding behavior. Orexin A human, rat, mouse is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.

HY-114370

Selpercatinib LOXO-292	RET	Cancer
Selpercatinib (LOXO-292) is a RET kinase inhibitor extracted from patent WO2018071447A1, Compound Example 163, has an IC₅₀ of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M) , and RET (G810R), respectively. Antineoplastic activity.

HY-136175

SNDX-5613	Epigenetic Reader Domain	Cancer
SNDX-5613 is a potent and specific Menin-MLL inhibitor with a binding K_i of 0.149 nM and a cell based IC₅₀ of 10-20 nM. SNDX-5613 can be used for the research of MLL-rearranged (MLL-r) acute leukemias, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML).

HY-129492

GNF4877	DYRK GSK-3	Metabolic Disease
GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC₅₀s of 6 nM and 16 nM, respectively, which leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation (EC₅₀ of 0.66 μM for mouse β (R7T1) cells).

HY-P1110

AF12198	Interleukin Related	Inflammation/Immunology
AF12198 is a potent, selective and specific peptide antagonist for human type I interleukin-1 receptor (IL1-R1) (IC₅₀=8 nM) but not the human type II receptor (IC₅₀=6.7 µM) or the murine type I receptor (IC₅₀>200 µM). AF12198 inhibits IL-1-induced IL-8 production (IC₅₀=25 nM) and IL-1-induced intercellular adhesion molecule-1 (ICAM-1) expression (IC₅₀=9 nM) in vitro. AF12198 has anti-inflammatory activities and blocks responses to IL-1 in vivo.

HY-P2141A

TRV-120027 TFA	Angiotensin Receptor	Cardiovascular Disease
TRV120027 TFA, a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R), engages ß-arrestins while blocking G-protein signaling. TRV120027 TFA induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R–β-arrestin-1–TRPC3–PLCγ at the plasma membrane. TRV120027 TFA inhibits angiotensin II–mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 TFA has the potential for the acute decompensated heart failure (ADHF) treatment.

HY-17385

Atomoxetine hydrochloride Tomoxetine hydrochloride; LY 139603; (R)-Tomoxetine hydrochloride	Others	Neurological Disease
Atomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5, 77 and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively).

HY-90005S

Etravirine D4 TMC-125 D4; R-165335 D4	Reverse Transcriptase HIV	Infection
Etravirine D4 is the deuterium labeled Etravirine. Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.

HY-41700

D-Alanine
(R)-Alanine; Ba 2776; D-α-Alanine
Endogenous Metabolite Others

D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC₅₀ of 9 mM for GlyR.

HY-101588

Gefapixant MK-7264; AF-219	P2X Receptor	Inflammation/Immunology
Gefapixant (MK-7264) is an orally active P2X3 receptor (P2X3R) antagonist with IC₅₀s of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors.

HY-123921

Gefitinib-based PROTAC 3	PROTAC EGFR	Cancer
Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC₅₀s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively.

HY-14151

Prucalopride	5-HT Receptor	Neurological Disease
Prucalopride (R093877) is a drug acting as a selective, high affinity 5-HT4 receptor agonist(pKi=8.6/8.1 for 5-HT4a/4b); >150-fold higher affinity for 5-HT4 receptors than for other receptors.

HY-N7539

Cognac oil	Others	Metabolic Disease
Cognac oil, mainly found in wine lees, has unique fatty acid profiles, including Palmitic acid (59.26%), Linoleic acid (11.92%), Myristic acid (8.97%), Oleic acid (8.3%) and other fatty acids. Cognac oil leads to a general increase in the permeation of R6G (Rhodamine 6G) across all the membranes.

HY-N2273

Gymnestrogenin	LXR	Metabolic Disease
Gymnestrogenin is a pentahydroxytriterpene from the leaves of Gymnema sylvestre R.Br. Gymnestrogenin is a LXR antagonist with IC₅₀s of 2.5 and 1.4 μM for LXRα and LXRβ transactivation, respectively. Gymnestrogenin reduces the transcriptional activity of LXR even on its own promoter, thus reducing the mRNA expression.

HY-111759

Jaspamycin 7-CN-7-C-Ino	PKA Parasite	Infection
Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA, binding to the R site (PKAR), with an EC₅₀ of 6.5 nM and K_d of 8 nM in Trypanosoma brucei. Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite activity.

HY-100452

TCS-OX2-29	Orexin Receptor (OX Receptor)	Cancer Endocrinology
TCS-OX2-29 is a potent, high affinities and selective orexin-2 receptor (OX₂R) antagonist with an IC₅₀ value of 40 nM and a pK_I value of 7.5. TCS-OX2-29 displays ~250-fold selectivity for OX₂ over OX₁.

HY-P2336

CCZ01048	Melanocortin Receptor	Cancer
CCZ01048, a α-melanocyte-stimulating hormone (α-MSH) analogue, exhibits high binding affinity to melanocortin 1 receptor *(MC1R)* with a K_i of 0.31 nM. CCZ01048 shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 is a promising candidate for PET imaging of malignant melanoma.

HY-112801

F-1	ALK ROS	Cancer
F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathways, with IC₅₀s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALK^WT, ROS1^WT, ALK^L1196M and ALK^G1202R, respectively.

HY-106224A

Orexin A (human, rat, mouse) (TFA)	Orexin Receptor (OX Receptor)	Neurological Disease
Orexin A human, rat, mouse TFA, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A human, rat, mouse TFA is a specific, high-affinity agonist for G-protein-coupled receptor *OX1R*. Orexin A human, rat, mouse TFA has a role in the regulation of feeding behavior. Orexin A human, rat, mouse TFA is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.

HY-P2336A

CCZ01048 TFA	Melanocortin Receptor	Cancer
CCZ01048 TFA, a α-MSH analogue, exhibits high binding affinity to melanocortin 1 receptor *(MC1R)* with a K_i of 0.31 nM. CCZ01048 TFA shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 TFA is a promising candidate for PET imaging of malignant melanoma.

HY-125841

EGFR mutant-IN-1	EGFR	Cancer
EGFR mutant-IN-1, a 5-methylpyrimidopyridone derivative, is a potent and selective EGFR^{L858R/T790M/C797S} mutant inhibitor with an IC₅₀ of 27.5 nM, while being a significantly less potent for EGFR^WT (IC₅₀ >1.0 μM).

HY-18137

PF-04995274	5-HT Receptor	Neurological Disease
PF-04995274 is a potent, high-affinity, orally active and partial serotonin 4 receptor (5-HT₄R) agonist. PF-04995274 has an EC₅₀ range of 0.26-0.47 nM for human 5-HT_4A/4B/4D/4E (K_i range of 0.15-0.46 nM), and has an EC₅₀ range of 0.59-0.65 nM for rat 5-HT_4S/4L/4E (K_i of 0.30 nM for rat 5-HT_4S). PF-04995274 is brain penetrant and can be used for cognitive disorders associated with Alzheimer's disease.

HY-109043A

Solriamfetol hydrochloride JZP-110 hydrochloride; ADX-N05 hydrochloride; R228060 hydrochloride	Dopamine Receptor	Neurological Disease
Solriamfetol hydrochloride (JZP-110 hydrochloride) is an orally active and selective dopamine and norepinephrine reuptake inhibitor with IC₅₀s of 2.9 μM and 4.4 μM for dopamine and norepinephrine transporters, respectively. Solriamfetol hydrochloride has robust wake-promoting effects.

HY-16900

Rolipram (R,S)-Rolipram; SB 95952; ZK 62711	Phosphodiesterase (PDE) Bacterial HIV	Neurological Disease Cancer
Rolipram is a selective phosphodiesterases PDE4 inhibitor with IC₅₀s of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.

HY-100360

MS049	Histone Methyltransferase	Cancer
MS049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC₅₀s of 34 nM and 43 nM, respectively. MS049 reduces levels of Med12me2a and H3R2me2a in HEK293 cells. MS049 is not toxic and do not affect the growth of HEK293 cells.

HY-100360A

MS049 dihydrochloride	Histone Methyltransferase	Cancer
MS049 dihydrochloride is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC₅₀s of 34 nM and 43 nM, respectively. MS049 dihydrochloride reduces levels of Med12me2a and H3R2me2a in HEK293 cells. MS049 dihydrochloride is not toxic and do not affect the growth of HEK293 cells.

HY-13011

Alectinib CH5424802; RO5424802; AF802	ALK	Cancer
Alectinib (CH5424802) is a potent, selective, and orally available ALK inhibitor with an IC₅₀ of 1.9 nM and a K_d value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC₅₀s of 1 nM and 3.5 nM, respectively. Alectinib demonstrates effective central nervous system (CNS) penetration.

HY-117273

AZ304	Raf Autophagy	Cancer
AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits wild type BRAF, V600E mutant BRAF and wild type CRAF, with IC₅₀s of 79 nM, 38 nM and 68 nM, respectively. AZ304 also has significant effect on other kinases, such as p38 (IC₅₀, 6 nM), CSF1R (IC₅₀, 35 nM). Anti-tumor activity.

HY-13011A

Alectinib Hydrochloride CH5424802 Hydrochloride; RO5424802 Hydrochloride; AF-802 Hydrochloride	ALK	Cancer
Alectinib Hydrochloride (CH5424802 Hydrochloride; RO5424802 Hydrochloride; AF-802 Hydrochloride) is a potent, selective, and orally available ALK inhibitor with an IC₅₀ of 1.9 nM and a K_d value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC₅₀s of 1 nM and 3.5 nM, respectively. Alectinib demonstrates effective central nervous system (CNS) penetration.

HY-19834

Fenebrutinib GDC-0853	Btk	Cancer
Fenebrutinib (GDC-0853) is a potent, selective, orally available, and noncovalent bruton's tyrosine kinase (Btk) inhibitor with K_is of 0.91 nM, 1.6, 1.3, 12.6, and 3.4 nM for WT Btk, and the C481S, C481R, T474I, T474M mutants. Fenebrutinib has the potential for rheumatoid arthritis and systemic lupus erythematosus research.

HY-11109

Resatorvid TAK-242; CLI-095	Toll-like Receptor (TLR) TNF Receptor Interleukin Related Autophagy	Inflammation/Immunology Cancer
Resatorvid (TAK-242) is a selective Toll-like receptor 4 (TLR4) inhibitor. Resatorvid inhibits NO, TNF-R and IL-6 production with IC_50s of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy and plays pivotal role in various inflammatory diseases.

HY-10200

BMS-754807	IGF-1R Insulin Receptor	Cancer Endocrinology
BMS-754807 is a potent and reversible *IGF-1R*/IR inhibitor (IC₅₀=1.8 and 1.7 nM, respectively; K_i=<2 nM for both). BMS-754807 also shows potent activities against Met, RON, TrkA, TrkB, AurA, and AurB with IC₅₀ values of 6, 44, 7, 4, 9, and 25 nM, respectively.

HY-130616

EGFR-IN-11	EGFR	Cancer
EGFR-IN-11 is a fourth-generation EGFR-tyrosine kinase inhibitor (EGFR-TKI) with an IC₅₀ of 18 nM for triple mutant EGFR^{L858R/T790M/C797S}. EGFR-IN-11 significantly suppresses the EGFR phosphorylation, induce the apoptosis, and arrest cell cycle at G0/G1.

HY-15971A

AMD 3465 GENZ-644494	CXCR HIV	Infection Endocrinology
AMD 3465 (GENZ-644494) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12^AF647 to CXCR4, with IC₅₀s of 0.75 nM and 18 nM in SupT1 cells; AMD 3465 also potently inhibits the replication of X4 HIV strains (IC₅₀: 1-10 nM), but has no effect on CCR5-using (R5) viruses.

HY-B0847

Propiconazole	Fungal Reactive Oxygen Species
Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption. Propiconazole inhibits *S. cerevisiae, but not rat liver, microsomal cytochrome P450* (IC₅₀s = 0.04 µM and >200 µM, respectively). Propiconazole inhibits the growth of *T. deformans* and *R. stolonifer* (ED₅₀s = 0.073 µg/mL and 4.6 µg/mL respectively). Propiconazole increases production of reactive oxygen species (ROS).

HY-N6972

Cepharanthine	HIV Autophagy Apoptosis	Cancer Infection Inflammation/Immunology
Cepharanthine, an alkaloid derived from Stephania cepharantha Hayata, with possesses anti-inflammatory and antioxidative activities. Cepharanthine attenuates muscle and kidney injuries induced by limb ischemia/reperfusion (I/R). Cepharanthine induces autophagy, apoptosis and cell cycle arrest in breast cancer cells. Cepharanthine inhibits the HIV-1 entry process by reducing plasma membrane fluidity.

HY-15971

AMD 3465 hexahydrobromide GENZ-644494 hexahydrobromide	CXCR HIV	Infection Endocrinology
AMD 3465 hexahydrobromide (GENZ-644494 hexahydrobromide) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12^AF647 to CXCR4, with IC₅₀s of 0.75 nM and 18 nM in SupT1 cells; AMD 3465 also potently inhibits the replication of X4 HIV strains (IC₅₀: 1-10 nM), but has no effect on CCR5-using (R5) viruses.

HY-131003

Taletrectinib DS-6051b; AB-106	ROS	Cancer
Taletrectinib (DS-6051b) is a potent, orally active, and new-generation selective ROS1/NTRK inhibitor. Taletrectinib potently inhibits recombinant ROS1, NTRK1, and NTRK3 with IC₅₀s of 0.207, 0.622, 2.28, and 0.98 nM, respectively. Taletrectinib also inhibits ROS1 G2032R and other Crizotinib-resistant ROS1 mutants.

HY-125789

PF-04753299	Bacterial	Infection
PF-04753299 is a potent and selective UDP-3-O-(R-3-hydroxymyristol)-N-acetylglucosamine deacetylase (LpxC) inhibitor. PF-04753299 is bactericidal for the gonococcal isolates. PF-04753299 inhibits E. coli, P. aeruginosa and K. pneumoniae strains with MIC₉₀ values of 2 μg/ml, 4 μg/ml and 16 μg/ml, respectively. PF-04753299 is used for the study of gram-negative bacteria infection.

HY-136057

iFSP1	Ferroptosis	Cancer
iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1) (AIFM2) with an EC₅₀ of 103 nM. iFSP1 selectively induces ferroptosis in GPX4-knockout cells which overexpressed FSP1. iFSP1 is able to sensitize a variety of human cancer cell lines to the ferroptosis inducer, such as (1S,3R)-RSL3 (HY-100218A).

HY-131003A

Taletrectinib free base DS-6051b free base; AB-106 free base	ROS	Cancer
Taletrectinib (DS-6051b) free base is a potent, orally active, and new-generation selective ROS1/NTRK inhibitor. Taletrectinib free base potently inhibits recombinant ROS1, NTRK1, and NTRK3 with IC₅₀s of 0.207, 0.622, 2.28, and 0.98 nM, respectively. Taletrectinib free base also inhibits ROS1 G2032R and other Crizotinib-resistant ROS1 mutants.

HY-109086

Edicotinib JNJ-40346527; JNJ-527	c-Fms	Inflammation/Immunology Neurological Disease
Edicotinib (JNJ-40346527) is a potent, selective, brain penetrant and orally active colony-stimulating factor-1 receptor (CSF-1R) inhibitor with an IC₅₀ of 3.2 nM. Edicotinib exhibits less inhibitory effects on KIT and FLT3 with IC₅₀ values of 20 nM and 190 nM, respectively. Edicotinib limits microglial expansion and attenuates microglial proliferation and neurodegeneration in mice. Edicotinib has the potential for Alzheimer’s disease and rheumatoid arthritis research.

HY-135887

ZX-29	ALK Apoptosis Autophagy	Cancer
ZX-29 is a potent and selective ALK inhibitor with an IC₅₀ of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively. ZX-29 is inactive against EGFR. ZX-29 induces apoptosis by inducing endoplasmic reticulum (ER) stress and overcomes cell resistance caused by an ALK mutation. ZX-29 also induces protective autophagy and has antitumor effect.

HY-17499

EGFR-IN-12	EGFR Apoptosis	Cancer
EGFR-IN-12 is a 4,6-disubstituted pyrimidine and is a potent, ATP-competitive, irreversible and highly selective EGFR inhibitor with an IC₅₀of 21 nM. EGFR-IN-12 also inhibits mutant EGFR^L858R and EGFR^L861Q with IC₅₀s of 63 nM and 4 nM, respectively. EGFR-IN-12 displays strong selectivity for EGFR over HER4 (IC₅₀ = 7640 nM) and a panel of 55 other kinases. EGFR-IN-12 induces cells apoptosis and has antitumor activity.

HY-12545

Brevetoxin-3 PbTx-3	Sodium Channel	Inflammation/Immunology
Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na⁺ channel activator and has multiple active centers (A-ring lactone, C-42 of R side chain). Brevetoxin-3 (PbTx-3) has a high affinity to site 5 of the voltage-sensitive Na⁺ channels, inhibits the inactivation of Na⁺ channels and prolongs the mean open time of these channels. Brevetoxin-3 (PbTx-3) repeated exposures can lead to prolonged airway hyperresponsiveness (AHR) and lung inflammation.

HY-101198

Clobenpropit dihydrobromide	Histamine Receptor	Cancer Neurological Disease
Clobenpropit dihydrobromide is a potent histamine H3R antagonist/inverse agonist with a pEC₅₀ of 8.07 for histamine H3LR. Clobenpropit dihydrobromide acts as partial agonist at histamine H4 receptors (K_i 13 nM). Clobenpropit dihydrobromide also binds to serotonin 5-HT3 receptors (K_i 7.4 nM) and α2A/α2C adrenoceptors (K_i 17.4/7.8 nM). Clobenpropit dihydrobromide increases apoptosis.

HY-103369

PG01	CFTR	Endocrinology
PG01 is a potent CFTR Cl^- channel potentiator. PG01 can correct gating defects of CFTR mutants, is effective on b>E193K, *G970R* and G551D (CFTR mutants) with K_d values of 0.22 μM, 0.45 μM and 1.94 μM, respectively. PG01 is also effective on ΔF508 (K_a of 0.3 μM). PG01 increases ΔF508-CFTR Cl^- current after adding Forskolin.

HY-120944

BAY-7598	MMP	Inflammation/Immunology
BAY-7598 is a potent, orally bioavailable, and selective MMP12 inhibitor probe with IC₅₀s of 0.085, 0.67 and 1.1 nM for human MMP12, murine MMP12, and rat MMP12, respectively.

HY-W040055

D-(+)-Neopterin 2-Amino-6-((1S,2R)-1,2,3-trihydroxypropyl)pteridin-4(3H)-one	Endogenous Metabolite	Inflammation/Immunology
D-(+)-Neopterin, a catabolic product of guanosine triphosphate (GTM), serves as a marker of cellular immune system activation.

HY-B0850

Difenoconazole	Fungal
Difenoconazole is a broad-spectrum triazole fungicide that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death. Difenoconazole inhibits the growth of *F. graminearum* isolates in vitro (EC₅₀s = 1.69-19.6 mg/L for mycelial growth). Difenoconazole also inhibits growth of *A. sonali, F. fulva, B. cinerea, and R. solani* (EC₅₀s = 0.131 mg/L, 0.069 mg/L, 0.297 mg/L, and 0.252 mg/L, respectively).

HY-N0408

Picroside II	NF-κB Reactive Oxygen Species Apoptosis Influenza Virus	Cancer Infection Inflammation/Immunology Neurological Disease
Picroside II, an iridoid compound extracted from Picrorhiza, exhibits anti-inflammatory and anti-apoptotic activities. picroside II alleviates the inflammatory response in sepsis and enhances immune function by inhibiting the activation of NLRP3 inflammasome and NF-κB pathways. Picroside II is an antioxidant, exhibits a significant neuroprotective effect through reducing ROS production and protects the blood-brain barrier (BBB) after cerebral ischemia-reperfusion (CI/R) injury. Picroside II has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities.

HY-15514A

Merestinib dihydrochloride LY2801653 dihydrochloride	c-Met/HGFR FLT3 ROS Discoidin Domain Receptor	Cancer
Merestinib dihydrochloride (LY2801653 dihydrochloride) is a potent, orally bioavailable c-Met inhibitor (K_i=2 nM) with anti-tumor activities. Merestinib dihydrochloride also has potent activity against MST1R (IC₅₀=11 nM), FLT3 (IC₅₀=7 nM), AXL (IC₅₀=2 nM), MERTK (IC₅₀=10 nM), TEK (IC₅₀=63 nM), ROS1, DDR1/2 (IC₅₀=0.1/7 nM) and MKNK1/2 (IC₅₀=7 nM).

HY-15514

Merestinib LY2801653	c-Met/HGFR FLT3 ROS Discoidin Domain Receptor	Cancer
Merestinib (LY2801653) is a potent, orally bioavailable c-Met inhibitor (K_i=2 nM) with anti-tumor activities. Merestinib (LY2801653) also has potent activity against MST1R (IC₅₀=11 nM), FLT3 (IC₅₀=7 nM), AXL (IC₅₀=2 nM), MERTK (IC₅₀=10 nM), TEK (IC₅₀=63 nM), ROS1, DDR1/2 (IC₅₀=0.1/7 nM) and MKNK1/2 (IC₅₀=7 nM).

HY-15730

Poziotinib HM781-36B; NOV120101	EGFR Apoptosis	Cancer
Poziotinib (HM781-36B) is an orally active, irreversible pan-HER inhibitor, which effectively inhibits EGFR^wt, HER-2 and HER-4 with IC₅₀s of 3.2, 5.3 and 23.5 nM, respectively. Poziotinib (HM781-36B) also shows excellent inhibitory activities against mutated EGFRs, including EGFR^T790M and EGFR^L858R/T790M, with IC₅₀s of 4.2 and 2.2 nM, respectively. Excellent antitumor activity.

HY-13238

Dolutegravir S/GSK1349572	HIV Integrase HIV	Infection
Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC₅₀ of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC₅₀ of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC₅₀=3.6-5.8 nM).

HY-13238A

Dolutegravir sodium S/GSK1349572 sodium	HIV Integrase HIV	Infection
Dolutegravir sodium (S/GSK1349572 sodium) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC₅₀ of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir sodium (S/GSK1349572 sodium) inhibits HIV-1 viral replication with an IC₅₀ of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir sodium (S/GSK1349572 sodium) retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC₅₀=3.6-5.8 nM).

HY-101522

CHMFL-EGFR-202	EGFR BMX Kinase Btk MEK	Cancer
CHMFL-EGFR-202 is a potent, irreversible inhibitor of epidermal growth factor receptor (EGFR) mutant kinase, with IC₅₀s of 5.3 nM and 8.3 nM for drug-resistant mutant EGFR T790M and WT EGFR kinases, respectively. CHMFL-EGFR-202 exhibits ∼10-fold selectivity for EGFR L858R/T790M against the EGFR wild-type in cells. CHMFL-EGFR-202 adopts a covalent “DFG-in-C-helix-out” inactive binding conformation with EGFR, with strong antiproliferative effects against EGFR mutant-driven nonsmall-cell lung cancer (NSCLC) cell lines.

HY-101034

CHMFL-ABL/KIT-155 CHMFL-ABL-KIT-155	Bcr-Abl c-Kit Apoptosis	Cancer
CHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155; compound 34) is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor (IC₅₀s of 46 nM and 75 nM, respectively), and it also presents significant inhibitory activities to BLK (IC₅₀=81 nM), CSF1R (IC₅₀=227 nM), DDR1 (IC₅₀=116 nM), DDR2 (IC₅₀=325 nM), LCK (IC₅₀=12 nM) and PDGFRβ (IC₅₀=80 nM) kinases. CHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155) arrests cell cycle progression and induces apoptosis.

Cat. No.	Product Name

HY-L034

Anti-Aging Compound Library 2299 compounds

A unique collection of 2299 bioactive anti-aging compounds for high throughput screening (HTS) and high content screening (HCS).

HY-L018

TGF-beta/Smad Compound Library

110 compounds

The transforming growth factor beta (TGF-β) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. The TGF-β superfamily comprises TGF-βs, bone morphogenetic proteins (BMPs), activins and related proteins. Signaling begins with the binding of a TGF beta superfamily ligand to a TGF beta type II receptor. The type II receptor is a serine/threonine receptor kinase, which catalyzes the phosphorylation of the Type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD (e.g. SMAD4). R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression. Deregulation of TGF-β signaling contributes to developmental defects and human diseases, including cancers, some bone diseases, chronic kidney disease, etc.

MCE designs a unique collection of 110 TGF-beta/Smad signaling pathway compounds. TGF-beta/Smad Compound Library acts as a useful tool for TGF-beta/Smad-related drug screening and disease research.

Cat. No.	Product Name	Type

HY-D0816

Rhodamine 123
RH-123; R-22420
Fluorescent Dyes/Probes

Rhodamine 123 (RH-123; R-22420) is a fluorescent dye (λ_ex=503 nm, λ_em=527 nm).
HY-D0193

Ponceau 4R
Acid Red 18; New Coccine
Dyes

Ponceau 4R is a synthetic colourant that may be used as a food colouring.
HY-129042

Cibacron Blue 3G-A
Dyes

Cibacron Blue 3G-A is an anthraquinone dye, inhibits the R46 β-lactamase with a K_i value of 1.2 uM.

Cat. No.	Product Name	Target	Research Area

HY-P2282

APTSTAT3-9R	STAT	Cancer
APTSTAT3-9R, a specific STAT3-binding peptide, inhibits STAT3 activation and downstream signaling by specifically blocking STAT3 phosphorylation. APTSTAT3-9R exerts antiproliferative effects and antitumor activity.

HY-P1430

11R-VIVIT	Peptides
11R-VIVIT is a potent NFAT inhibitor. 11R-VIVIT inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). 11R-VIVIT also attenuates NO production and Nos2 mRNA expression in LPS-stimulated BMDMs. 11R-VIVIT improves symptoms in a mouse model of colitis. Exhibits immunosuppressive effects; enhances graft survival in mice.

HY-P1404

R8-T198wt	Pim
R8-T198wt is a cell-permeable peptide inhibitor of Pim-1 kinase, derived from p27Kip1. R8-T198wt inhibits Pim-1 phosphorylation of p27Kip1 and Bad; induces cell cycle arrest (at G1) and apoptosis in DU145 prostate cancer cells. R8-T198wt also inhibits Pim-1-dependent growth of DU145 cells in vitro and in vivo. R8-T198wt displays no effect on the growth of normal prostate epithelial RPWE-1 cells at concentrations of 10 and 20 μM.

HY-P1430A

11R-VIVIT TFA	Peptides
11R-VIVIT TFA is a potent NFAT inhibitor. 11R-VIVIT TFA inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). 11R-VIVIT TFA also attenuates NO production and Nos2 mRNA expression in LPS-stimulated BMDMs. 11R-VIVIT TFA improves symptoms in a mouse model of colitis. Exhibits immunosuppressive effects; enhances graft survival in mice.

HY-P1851

AGA-(C8R) HNG17, Humanin derivative	Peptides	Neurological Disease
AGA-(C8R) HNG17, Humanin derivative is a potent humanin (HN) derivative. AGA-(C8R) HNG17, Humanin derivative completely suppresses neuronal cell death by Alzheimer's disease-relevant insults.

HY-P2247

JTP10-△-R9 TFA
JNK Cancer

JTP10-△-R9 TFA is a selective JNK2 peptide inhibitor, with an IC₅₀ of 89 nM, exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3.

HY-P1851A

AGA-(C8R) HNG17, Humanin derivative TFA	Peptides	Neurological Disease
AGA-(C8R) HNG17, Humanin derivative TFA is a potent humanin (HN) derivative. AGA-(C8R) HNG17, Humanin derivative completely suppresses neuronal cell death by Alzheimer's disease-relevant insults.

HY-P1175

L-R4W2
TRP Channel Neurological Disease

L-R4W2 is a potent antagonist of vanilloid receptor 1 (VR1, TRPV1), with an IC₅₀ of 0.1 μM. L-R4W2 may act as a potent analgesic.

HY-P1039A

R18 TFA PHCVPRDLSWLDLEANMCLP TFA	Peptides	Cancer
R18 TFA is a peptide antagonists of 14-3-3, with a K_D of 70-90 nM. R18 efficiently blocks the binding of 14-3-3 to the kinase Raf-1, a physiological ligand of 14-3-3, and effectively abolished the protective role of 14-3-3 against phosphatase-induced inactivation of Raf-1.

HY-P1175A

L-R4W2 TFA
TRP Channel Neurological Disease

L-R4W2 TFA is a potent antagonist of vanilloid receptor 1 (VR1, TRPV1), with an IC₅₀ of 0.1 μM. L-R4W2 TFA may act as a potent analgesic.

HY-P1205A

MCH(human, mouse, rat) TFA	MCHR1 (GPR24)	Neurological Disease
MCH (human, mouse, rat) TFA is a potent peptide agonist of *MCH-R* and exhibits binding IC₅₀ values of 0.3nM and 1.5 nM for MCH1R and MCH2R, respectively. MCH (human, mouse, rat) is a highly sensitive to MCH-2R in a CHO cell line and monitoring mobilization of intracellular calcium with FLIPR, exhibits functional activation EC₅₀ values of 3.9 nM and 0.1nM for human MCH-1R and MCH-2R, respectively.

HY-P1205

MCH(human, mouse, rat)	MCHR1 (GPR24)	Neurological Disease
MCH (human, mouse, rat) is a potent peptide agonist of *MCH-R* and exhibits binding IC₅₀ values of 0.3nM and 1.5 nM for MCH1R and MCH2R, respectively. MCH (human, mouse, rat) is a highly sensitive to MCH-2R in a CHO cell line and monitoring mobilization of intracellular calcium with FLIPR, exhibits functional activation EC₅₀ values of 3.9 nM and 0.1nM for human MCH-1R and MCH-2R, respectively.

HY-P1540

Angiotensin III, human, mouse	Angiotensin Receptor	Cardiovascular Disease Endocrinology
Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT₂R) agonist, with IC₅₀s of 0.648 nM and 21.1 nM for AT₂R and AT₁R, respectively.

HY-P2242A

RO27-3225 TFA	Melanocortin Receptor	Inflammation/Immunology Neurological Disease
RO27-3225 TFA is potent and selective melanocortin 4 receptor (MC4R) agonist with an EC₅₀ of 1 nM and 8 nM for *MC4R* and MC1R, respectively. RO27-3225 TFA shows ~30-fold selectivity for *MC4R* over MC3R. RO27-3225 TFA has neuroprotective and anti-inflammatory effects.

HY-P0242

Neurokinin B	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin B belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect.

HY-P0242A

Neurokinin B TFA	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin B TFA belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect.

HY-P1810

c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-Agm	Peptides	Neurological Disease
c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-Agm is a is a potent, selective and short-acting peptidic V₂ receptor (V₂R) agonist with EC₅₀s of 0.25 and 0.05 nM for hV₂R and rV₂R, respectively.

HY-P1504

β-Melanocyte Stimulating Hormone (MSH), human Beta-MSH (1-22) (human)	Melanocortin Receptor	Metabolic Disease Neurological Disease Endocrinology
β-Melanocyte Stimulating Hormone (MSH), human, a 22-residue peptide, acts as an endogenous melanocortin-4 receptor (MC4-R) agonist.

HY-P1504A

β-Melanocyte Stimulating Hormone (MSH), human TFA Beta-MSH (1-22) (human) TFA	Melanocortin Receptor	Metabolic Disease Neurological Disease Endocrinology
β-Melanocyte Stimulating Hormone (MSH), human TFA, a 22-residue peptide, acts as an endogenous melanocortin-4 receptor (MC4-R) agonist.

HY-P1852

TIP 39, Tuberoinfundibular Neuropeptide	Adenylate Cyclase	Neurological Disease
TIP 39, Tuberoinfundibular Neuropeptide is a neuropeptide and parathyroid hormone 2 receptor (PTH2R) agonist. TIP 39 is highly conserved among species. TIP39 from all species activates adenylyl cyclase and elevates intracellular calcium levels through parathyroid hormone 2 receptor (PTH2R).

HY-P1809

c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-d-Arg-NEt2	Peptides	Metabolic Disease
c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-d-Arg-NEt2 is a potent, selective and short-acting peptidic V₂ receptor (V₂R) agonist with EC₅₀s of 0.07 and 0.02 nM for hV₂R and rV₂R, respectively.

HY-P1809A

c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-d-Arg-NEt2 acetate	Peptides	Metabolic Disease
c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-d-Arg-NEt2 acetate is a potent, selective and short-acting peptidic V₂ receptor (V₂R) agonist with EC₅₀s of 0.07 and 0.02 nM for hV₂R and rV₂R, respectively.

HY-19870B

Setmelanotide acetate RM-493 acetate; BIM-22493 acetate; IRC-022493 acetate	Melanocortin Receptor	Endocrinology Metabolic Disease
Setmelanotide acetate (RM-493 acetate) is a selective melanocortin 4 receptor (MC4R) agonist with EC₅₀s of 0.27 nM and 0.28 nM for human and rat MC4R, respectively.

HY-19870A

Setmelanotide TFA RM-493 TFA; BIM-22493 TFA; IRC-022493 TFA	Melanocortin Receptor	Metabolic Disease Endocrinology
Setmelanotide TFA (RM-493 TFA) is a selective melanocortin 4 receptor (MC4R) agonist with EC₅₀s of 0.27 nM and 0.28 nM for human and rat MC4R, respectively.

HY-P0201A

Substance P TFA Neurokinin P TFA	Neurokinin Receptor	Endocrinology Neurological Disease
Substance P TFA (Neurokinin P TFA) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, *NK1R*).

HY-P2259

TAT-GluA2 3Y	iGluR
TAT-GluA2 3Y is an inhibitor of AMPA receptor endocytosis. TAT-GluA2 3Y induces increased hind paw withdrawal latencies following thermal and mechanical stimuli in rats. TAT-GluA2 3Y also exhibits antinociceptive effects in a rat model of neuropathic pain. TAT-GluA2 3Y rescues pentobarbital-induced memory retrieval deficits in a rat model of learning and memory.

HY-P1478

Adrenocorticotropic Hormone (ACTH) (4-10), human
Peptides Metabolic Disease

Adrenocorticotropic Hormone (ACTH) (4-10), human is a melanocortin 4 (MC4R) receptor agonist.
HY-P2382

TRV120056
Peptides Others

TRV120056 is a G_q-biased agonists, exhibits 10-fold larger molecular efficacies at the AT₁R-Gq fusion protein compared with the AT₁R-βarr2 fusion protein.
HY-P2381

TRV120055
Peptides Others

TRV120055 is a G_q-biased agonists, exhibits 10-fold larger molecular efficacies at the AT₁R-Gq fusion protein compared with the AT₁R-βarr2 fusion protein.

HY-P1531

γ-1-Melanocyte Stimulating Hormone (MSH), amide	Melanocortin Receptor	Metabolic Disease Endocrinology
γ-1-Melanocyte Stimulating Hormone (MSH), amide is a 11-amino acid peptide. γ-1-Melanocyte Stimulating Hormone (MSH) regulates sodium (Na⁺) balance and blood pressure through activation of the melanocortin receptor 3 (MC3-R).

HY-P1858

Urocortin III, mouse	CRFR	Neurological Disease Cardiovascular Disease Endocrinology
Urocortin III, mouse is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III preferentially binds and activates *CRF-R2*. Urocortin III (Ucn3) is a known component of the behavioral stress response system. Urocortin III and CRF-R2 in the medial amygdala regulate complex social dynamics.

HY-P1858A

Urocortin III, mouse TFA	CRFR	Neurological Disease Cardiovascular Disease Endocrinology
Urocortin III, mouse TFA is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III preferentially binds and activates *CRF-R2*. Urocortin III (Ucn3) is a known component of the behavioral stress response system. Urocortin III and CRF-R2 in the medial amygdala regulate complex social dynamics.

HY-P0076A

TAK-448 acetate
MVT-602 acetate
Peptides Cancer

TAK-448 acetate (MVT-602 acetate) is a potent and full KISS1R agonist with an IC₅₀ of 460 pM and an EC₅₀ of 632 pM.
HY-P0076

TAK-448
MVT-602
Peptides Cancer

TAK-448 (MVT-602) is a potent and full KISS1R agonist with an IC₅₀ of 460 pM and an EC₅₀ of 632 pM.

HY-P1208

PG-931	Melanocortin Receptor	Inflammation/Immunology
PG-931, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC₅₀=0.58 nM) agonist and is more selective than for the hMC3R (IC₅₀=55 nM) or the hMC5R (IC₅₀=2.4 nM). PG-931 can reverse haemorrhagic shock and prevent multiple organ damage in vivo.

HY-P0201

Substance P Neurokinin P	Neurokinin Receptor Endogenous Metabolite	Neurological Disease Endocrinology
Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, *NK1R*).

HY-P1208A

PG-931 TFA	Melanocortin Receptor	Inflammation/Immunology
PG-931 TFA, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC₅₀=0.58 nM) agonist and is more selective than for the hMC3R (IC₅₀=55 nM) or the hMC5R(IC₅₀=2.4 nM). PG-931 TFA can reverse haemorrhagic shock and prevent multiple organ damage in vivo.

HY-P2191

KISS1-305	Peptides	Endocrinology
KISS1-305, the Metastin/Kisspeptin analog, is a prototype peptide and a chemical probe. KISS1-305 has suboptimal *KISS1R* agonistic activity, and resists plasma protease degradation.

HY-P2161A

TAK-683 TFA	Peptides	Cancer
TAK-683 TFA is a potent full KISS1 receptor (KISS1R) agonist (IC₅₀=170 pM) with improved metabolic stability. TAK-683 TFA is a nonapeptide metastin analog, exhibits agonistic activities to KISS1R with EC₅₀ values of 0.96 nM and 1.6 nM for human and rat, respectively. TAK-683 TFA depletes GnRH in the hypothalamus and reduces plasma FSH, LH, and testosterone levels in vivo, it has the potential for the study of hormone-dependent prostate cancer.

HY-P0122

iRGD peptide c(CRGDKGPDC)	Integrin	Cancer
iRGD peptide is a 9-amino acid cyclic peptide, triggers tissue penetration of drugs by first binding to av integrins, then proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1, and has tumor-targeting and tumor-penetrating properties.

HY-P0049

Argipressin Vasopressin; Arg8-vasopressin; AVP	Vasopressin Receptor	Neurological Disease
Argipressin binds to the V1, V2, V3-vascular arginine vasopressin receptor, with a K_d value of 1.31 nM in A7r5 rat aortic smooth muscle cells for V1. Argipressin is a selective V2 agonist.

HY-P1074

SNX-482	Calcium Channel	Neurological Disease
SNX-482, a peptidyl toxin of the spider Hysterocrates gigas, is a potent, high affinity, selective and voltage-dependent R-type Ca_V2.3 channel blocker with an IC₅₀ of 30 nM. SNX-482 has antinociceptive effect.

HY-P2141

TRV-120027	Angiotensin Receptor	Cardiovascular Disease
TRV120027, a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R), engages ß-arrestins while blocking G-protein signaling. TRV120027 induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R–β-arrestin-1–TRPC3–PLCγ at the plasma membrane. TRV120027 inhibits angiotensin II–mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 has the potential for the acute decompensated heart failure (ADHF) treatment.

HY-106224

Orexin A (human, rat, mouse)	Orexin Receptor (OX Receptor)	Neurological Disease
Orexin A human, rat, mouse, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A human, rat, mouse is a specific, high-affinity agonist for G-protein-coupled receptor *OX1R*. Orexin A human, rat, mouse has a role in the regulation of feeding behavior. Orexin A human, rat, mouse is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.

HY-P2141A

TRV-120027 TFA	Angiotensin Receptor	Cardiovascular Disease
TRV120027 TFA, a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R), engages ß-arrestins while blocking G-protein signaling. TRV120027 TFA induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R–β-arrestin-1–TRPC3–PLCγ at the plasma membrane. TRV120027 TFA inhibits angiotensin II–mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 TFA has the potential for the acute decompensated heart failure (ADHF) treatment.

HY-P0133A

(Arg)9 TFA Nona-L-arginine TFA; Peptide R9 TFA	Peptides	Neurological Disease
(Arg)9 TFA (Nona-L-arginine TFA), a cell-penetrating peptide, exhibits neuroprotective activity with an IC₅₀ of 0.78 μM in the glutamic acid model.

HY-P2336

CCZ01048	Melanocortin Receptor	Cancer
CCZ01048, a α-melanocyte-stimulating hormone (α-MSH) analogue, exhibits high binding affinity to melanocortin 1 receptor *(MC1R)* with a K_i of 0.31 nM. CCZ01048 shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 is a promising candidate for PET imaging of malignant melanoma.

HY-106224A

Orexin A (human, rat, mouse) (TFA)	Orexin Receptor (OX Receptor)	Neurological Disease
Orexin A human, rat, mouse TFA, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A human, rat, mouse TFA is a specific, high-affinity agonist for G-protein-coupled receptor *OX1R*. Orexin A human, rat, mouse TFA has a role in the regulation of feeding behavior. Orexin A human, rat, mouse TFA is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.

HY-P2336A

CCZ01048 TFA	Melanocortin Receptor	Cancer
CCZ01048 TFA, a α-MSH analogue, exhibits high binding affinity to melanocortin 1 receptor *(MC1R)* with a K_i of 0.31 nM. CCZ01048 TFA shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 TFA is a promising candidate for PET imaging of malignant melanoma.

Cat. No.	Product Name	Target	Research Area

HY-P9803

Anti-SARS-80R mAb SARS-80R; SARS Antibody-80R	SARS-CoV	Infection
Anti-SARS-80R mAb (SARS-80R) is a human monoclonal IgG1 antibody produced in CHO cells. Anti-SARS-80R mAb can specifically bind to Spike (S1) protein to prevent SARS virus infection of susceptible cells.

HY-P9917

Tocilizumab Anti-Human IL6R, Humanized Antibody	Interleukin Related	Cancer Inflammation/Immunology
Tocilizumab (Anti-Human IL6R, Humanized Antibody) is an anti-human interleukin-6 receptor (IL-6R) neutralizing antibody, prevents binding of IL-6 to the IL-6R, thereby inhibiting both classic and trans-signaling. Tocilizumab (Anti-Human IL6R, Humanized Antibody) can be used for the treatment of rheumatoid arthritis. Tocilizumab is remarkablely effective for the study of severe COVID-19 (coronavirus disease).

Cat. No.	Product Name	Target	Category

HY-N6937

*(R,R)-Secoisolariciresinol diglucoside* (R,R)-SDG; (R,R)-LGM2605	Others	Phenylpropanoids Saccharides and Glycosides
(R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is the minor isomer of Secoisolariciresinol diglucoside in flaxseed. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) possesses antioxidant and free radical scavenging activities and DNA-radioprotective properties. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) inhibits myeloperoxidase (MPO) activity by suppressing both the peroxidase and chlorination cyclesin inflammatory cells.

HY-59125

(R,R)-(+)-Hydrobenzoin
Endogenous Metabolite Natural Products

(R,R)-(+)-Hydrobenzoin is a organocatalysts.
HY-N2049

20(R)-Notoginsenoside R2
Others Saccharides and Glycosides Terpenoids and Glycosides

20(R)-Notoginsenoside R2 is an isolated notoginsenoside from Panax notoginseng.
HY-W015954

(2R,3R)-Butane-2,3-diol
Endogenous Metabolite Natural Products

(2R,3R)-Butane-2,3-diol is an endogenous metabolite.
HY-B0357

Diclazuril
R-64433
Parasite Antibiotic Natural Products

Diclazuril (R-64433) is an anti-coccidial drug.

HY-75087

(R)-pyrrolidine-2-carboxylic acid (+)-(R)-Proline; (R)-(+)-Proline; (R)-2-Carboxypyrrolidine; (R)-Proline	Endogenous Metabolite	Acids and Aldehydes
(R)-pyrrolidine-2-carboxylic acid is an endogenous metabolite.

HY-124257

(R)-Citronellol D-Citronellol; (R)-(+)-β-Citronellol	Endogenous Metabolite	Terpenoids and Glycosides
(R)-Citronellol (D-Citronellol) is an alcoholic monoterpene found in geranium essential oil. (R)-Citronellol inhibits degranulation of mast cells and does not affect caffeine bitterness perception. (R)-Citronellol can be used in decorative cosmetics, toiletries as well as in non-cosmetic products.

HY-N2207

rel-(8R,8'R)-Dimethyl-(7S,7'R)-bis(3,4-methylenedioxyphenyl)tetrahydro-furan	Others	Phenylpropanoids
rel-(8R,8'R)-Dimethyl-(7S,7'R)-bis(3,4-methylenedioxyphenyl)tetrahydro-furan is a chemical constituent of the fruit of Myristica fragrans.

HY-N6679

(R)-10,11-Dehydrocurvularin	Others	Natural Products
(R)-10,11-Dehydrocurvularin is a secondary metabolite isolated from Curvularia sp.. (R)-10,11-Dehydrocurvularin displays concentration-dependent cytotoxicity towards human tumor cell lines with a mean IC₅₀ value of 1.25 µM.

HY-18733

Lipoic acid (R)-(+)-α-Lipoic acid; R-(+)-Thioctic acid	Mitochondrial Metabolism Endogenous Metabolite Reactive Oxygen Species	Acids and Aldehydes
Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.

HY-N1376

20(R)-Ginsenoside Rg3 20(R)-Propanaxadiol; R-ginsenoside Rg3	Others	Saccharides and Glycosides Terpenoids and Glycosides
20(R)-ginsenoside Rg3 (20(R)-Propanaxadiol), one of the active compounds present in ginseng root, has a potent angiosuppressive and antitumor activities.

HY-34516

(R)-Ornithine hydrochloride
Endogenous Metabolite Acids and Aldehydes

(R)-Ornithine hydrochloride is an endogenous metabolite.

HY-W051723

(R)-3-Hydroxybutanoic acid	Endogenous Metabolite	Acids and Aldehydes
(R)-3-Hydroxybutanoic acid is a metabolite, and converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase.

HY-111095B

(2R)-2-Hydroxypropanoate sodium
Endogenous Metabolite Acids and Aldehydes

(2R)-2-Hydroxypropanoate sodium is an endogenous metabolite.

HY-13755A

(R)-Sulforaphane	Others	Natural Products
(R)-Sulforaphane is a highly potent inducer of the Keap1/Nrf2/ARE pathway. (R)-Sulforaphane is a far more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer.

HY-N0615

Notoginsenoside R1 Sanchinoside R1; Sanqi glucoside R1	Amyloid-β	Saccharides and Glycosides Terpenoids and Glycosides
Notoginsenoside R1, the main bioactive component in panaxnotoginseng, is reported to have some neuronal protective, antihypertensive effects.

HY-100808

(R)-Serine	iGluR Endogenous Metabolite	Alkaloids Acids and Aldehydes
(R)-Serine, an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. (R)-Serine has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration.

HY-W002304

(R)-5-Oxopyrrolidine-2-carboxylic acid
Endogenous Metabolite Acids and Aldehydes

(R)-5-Oxopyrrolidine-2-carboxylic acid is an endogenous metabolite.

HY-N4266

Vinaginsenoside R8	Others	Saccharides and Glycosides Terpenoids and Glycosides
Vinaginsenoside R8, a triterpenoid glycoside isolated from the rhizomes of Panacis majoris. Vinaginsenoside R8 displays activities against adenosine diphosphate (ADP)-induced platelet aggregation (IC₅₀=25.18 μM).

HY-W021425

(2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride	Endogenous Metabolite	Natural Products
(2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride is an endogenous metabolite.

HY-N4131

25R-Inokosterone
Others Steroids

25R-Inokosterone is a phytoecdysone isolated from Achyranthis Radix.

HY-113108

(R)-3-Hydroxyisobutyric acid	Endogenous Metabolite	Acids and Aldehydes
(R)-3-Hydroxyisobutyric acid is an intermediate in the pathways of l-valine and thymine and plays an important role in the diagnosis of the very rare inherited metabolic diseases 3-hydroxyisobutyric aciduria and methylmalonic semialdehyde dehydrogenase deficiency.

HY-N6924

Zingibroside R1	HIV	Saccharides and Glycosides Terpenoids and Glycosides
Zingibroside R1 is dammaranae-type triterpenoid saponin, isolated from rhizomes, taproots, and lateral roots of Panax japonicas C. A. Meyer, shows excellent anti-tumor effects as well as anti-angiogenic activity. Zingibroside R1 possesses some anti-HIV-1 activity. Zingibroside R1 has inhibitory effects on the 2-deoxy-D-glucose (2-DG) uptake by EAT cells (IC₅₀=91.3 μM).

HY-B0454

Miconazole
R18134
Fungal Bacterial Antibiotic Natural Products

Miconazole (R18134) is an imidazole antifungal agent. Miconazole also has antibacterial effects.

HY-N1400

(20R)-Ginsenoside Rh1	Others	Saccharides and Glycosides Terpenoids and Glycosides
(20R)-Ginsenoside Rh1, the R isomer of Ginsenoside Rh1 isolated from Panax Ginseng, inhibits the thrombin-induced conversion of fibrinogen to fibrin.

HY-N0909

Notoginsenoside R2 20(S)-Notoginsenoside R2; Ginsenoside Ng-R2	Others	Saccharides and Glycosides Terpenoids and Glycosides
Notoginsenoside R2 is a newly isolated notoginsenoside from Panax notoginseng, showed neuroprotective effects against 6-OHDA-induced oxidative stress and apoptosis.

HY-N7025

Suavissimoside R1	Others	Terpenoids and Glycosides
Suavissimoside R1, isolated from the roots of Rubus parvifollus, possesses potent neuroprotective activity and has the potential to treat anti-Parkinson's disease drug.

HY-N2296

(2R,3R)-3,7-Dihydroxy-2-(4-hydroxyphenyl)-5-methoxy-8-(3-methylbut-2-en-1-yl)chroman-4-one	Others	Flavonoids
(2R,3R)-3,7,4'-Trihydroxy-5-methoxy-8-prenylflavanone can be used in a flame retardant for transparent polycarbonate products or in elevator illumination devices research.

HY-W050145

(1R,2S,3S,4R,5S)-6,8-Dioxabicyclo[3.2.1]octane-2,3,4-triol
Endogenous Metabolite Natural Products

(1R,2S,3S,4R,5S)-6,8-Dioxabicyclo[3.2.1]octane-2,3,4-triol is an endogenous metabolite.
HY-30216

(R)-Leucic acid
D-α-Hydroxyisocaproic acid
Endogenous Metabolite Acids and Aldehydes

(R)-Leucic acid is an amino acid metabolite.

HY-N1401

20(R)-Ginsenoside Rh2	MMP Apoptosis HSV	Saccharides and Glycosides Terpenoids and Glycosides
20(R)-Ginsenoside Rh2, a matrix metalloproteinase (MMP) inhibitor, acts as a cell antiproliferator. It has anticancer effects via blocking cell proliferation and causing G1 phase arrest. 20(R)-Ginsenoside Rh2 induces apoptosis, and has anti-inflammatory and antioxidative activity. 20(R)-Ginsenoside Rh2 inhibits the replication and proliferation of mouse and human gammaherpesvirus 68 (MHV-68) with an IC₅₀ of 2.77 μM for murine MHV-68.

HY-N6262

20(S),24(R)-Ocotillol
Others Terpenoids and Glycosides

20(S),24(R)-Ocotillol is isolated from Panax ginseng.

HY-N4265

Vinaginsenoside R4	Others	Saccharides and Glycosides Terpenoids and Glycosides
Vinaginsenoside R4, isolated from the leaves of hydroponic Panax ginseng. It has an inhibitory effect on melanin biosynthesis without any cytotoxic effects on the melan-a cells, and enhances the depigmentation on the zebrafish.

HY-111664

(R)-(+)-Citronellal (+)-Citronellal	Endogenous Metabolite	Terpenoids and Glycosides
(R)-(+)-Citronellal, isolated from citrus, lavender and eucalyptus oils, is a monoterpenoid and main component of citronellal oil with a distinct lemon scent. A flavouring agent. Used for insect repellent and antifungal properties.

HY-128732

rel-(2R,3S)-2,3-Dihydroxysuccinic acid hydrate
Endogenous Metabolite Acids and Aldehydes

rel-(2R,3S)-2,3-Dihydroxysuccinic acid (hydrate) is an endogenous metabolite.

HY-B0454A

Miconazole nitrate R18134 nitrate	Fungal Bacterial Antibiotic	Alkaloids
Miconazole nitrate (R18134 nitrate) is an imidazole antifungal agent. Miconazole nitrate also has antibacterial effects.

HY-113025A

L-hydroxylysine dihydrochloride (2S,5R)-5-Hydroxylysine dihydrochloride	Endogenous Metabolite	Acids and Aldehydes
L-hydroxylysine dihydrochloride ((2S,5R)-5-Hydroxylysine dihydrochloride), an amino acid, is exclusive to collagen protein, which is formed by posttranslational hydroxylation of some lysine residues.

HY-W010396

(R)-3-Hydroxy-4,4-dimethyldihydrofuran-2(3H)-one
Endogenous Metabolite Natural Products

(R)-3-Hydroxy-4,4-dimethyldihydrofuran-2(3H)-one is an endogenous metabolite.

HY-N2380

N-Benzoyl-(2R,3S)-3-phenylisoserine	Others	Alkaloids Acids and Aldehydes
N-Benzoyl-(2R,3S)-3-phenylisoserine is a Taxol C-13 Side Chain and crucial for the strong antitumor activity of Taxol.

HY-15464

(R)-(-)-Gossypol AT-101; R-(-)-gossypol acetic acid	Bcl-2 Family Autophagy	Phenols
(R)-(-)-Gossypol (AT-101) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, Mcl-1 and Bcl-xL proteins with K_is of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.

HY-W010271

(2S,3R,4S)-4-Hydroxyisoleucine (2S,3R,4S)-4-Hydroxy-L-isoleucine	Others	Natural Products
(2S,3R,4S)-4-Hydroxyisoleucine is an orally active compound isolated from Trigonella foenum-graecum, with anti-diabetes and anti-diabetic nephropathy activity.

HY-N4264

Vinaginsenoside R3	Others	Natural Products
Vinaginsenoside R3 is a saponin composition of roots of Panax ginseng. Ginsengs have been not only used as therapeutic agents with tonic, sedative, anti-fatigue, and anti-gastric ulcer effect but also marketed as dietary supplements and raw materials of health food.

HY-W013078

(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl ditetradecanoate	Endogenous Metabolite	Natural Products
(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl ditetradecanoate is an endogenous metabolite.

HY-N2039

20(R)-Ginsenoside Rg2	Others	Saccharides and Glycosides Terpenoids and Glycosides
20(R)-Ginsenoside Rg2, isolated from Ginseng stems and leaves, shows inhibitory effects on lung cancer NCI-H1650 cells. Anti-cancer activities.

HY-N1372

(R)-Fangchinoline Thalrugosine; Thaligine	Bacterial Antibiotic	Alkaloids
(R)-Fangchinoline (Thalrugosine), a alkaloids from genus Stephania，exhibits antimicrobial and hypotensive activity. The roots and stems of several plants from genus Stephania are all used as traditional Chinese medicine and have been used for treatment of fever, diarrhea, dyspepsia and urinary disease.

HY-108059

β-Cryptoxanthin (3R)-β-Cryptoxanthin	Endogenous Metabolite	Terpenoids and Glycosides
β-Cryptoxanthin ((3R)-β-Cryptoxanthin), isolated from Satsuma mandarin orange, is an oxygenated carotenoid and a potent antioxidant. β-Cryptoxanthin has an anti-stress effect.

HY-W040240

(3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one
Endogenous Metabolite Saccharides and Glycosides

(3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one is an endogenous metabolite.

HY-113038

D-α-Hydroxyglutaric acid (R)-2-Hydroxypentanedioic acid	Reactive Oxygen Species ATP Synthase mTOR Endogenous Metabolite	Acids and Aldehydes
D-α-Hydroxyglutaric acid ((R)-2-Hydroxypentanedioic acid) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a K_i of 10.87 mM. D-α-Hydroxyglutaric acid increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid binds and inhibits ATP synthase and inhibits mTOR signaling.

HY-13716

Noscapine (S,R)-Noscapine	Opioid Receptor Apoptosis	Alkaloids
Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can crosse the blood-brain barrier.

HY-N2185

(5R,6E)-5-Hydroxy-1,7-diphenyl-6-hepten-3-one	Others	Natural Products
(5R,6E)-5-Hydroxy-1,7-diphenyl-6-hepten-3-one is the methylene chloride extract of Alpinia nutans, has antioxidant activity.

HY-B0471

Phenylephrine hydrochloride (R)-(-)-Phenylephrine hydrochloride; L-Phenylephrine hydrochloride	Adrenergic Receptor Endogenous Metabolite	Natural Products
(R)-(-)-Phenylephrine hydrochloride is a selective α₁-adrenoceptor agonist with pK_is of 5.86, 4.87 and 4.70 for α_1D, α_1B and α_1A receptors respectively.

HY-42680

(3S,4S,5R)-1,3,4,5,6-Pentahydroxyhexan-2-one
Tagatose, D- (8CI)
Endogenous Metabolite Natural Products

(3S,4S,5R)-1,3,4,5,6-Pentahydroxyhexan-2-one is an endogenous metabolite.

HY-B2246

L-Carnitine hydrochloride (R)-Carnitine hydrochloride	Endogenous Metabolite	Acids and Aldehydes
L-Carnitine hydrochloride ((R)-Carnitine hydrochloride), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine hydrochloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine hydrochloride is an antioxidant. L-Carnitine hydrochloride can ameliorate metabolic imbalances in many inborn errors of metabolism.

HY-13716A

Noscapine hydrochloride (S,R)-Noscapine hydrochloride	Opioid Receptor Apoptosis	Alkaloids
Noscapine hydrochloride ((S,R)-Noscapine hydrochloride) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine hydrochloride exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine hydrochloride disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine hydrochloride possesses anticancer, neuroprotective, anti-inflammatory activities, and can crosse the blood-brain barrier.

HY-14608

(S)-Glutamic acid (+)-L-Glutamic acid	Endogenous Metabolite iGluR Ferroptosis Apoptosis	Alkaloids Acids and Aldehydes
(S)-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). (S)-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

HY-14608A

L-Glutamic acid monosodium salt Monosodium glutamate	iGluR Apoptosis Ferroptosis	Alkaloids Acids and Aldehydes
L-Glutamic acid monosodium salt acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). (S)-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

HY-41094

cis-Isolimonenol
(1S,4R)-p-Mentha-2,8-dien-1-ol
Others Terpenoids and Glycosides

cis-Isolimonenol ((1S,4R)-p-Mentha-2,8-dien-1-ol) is a chemical composition of essential oil.
HY-N0221

Daurisoline
(R,R)-Daurisoline
Autophagy Potassium Channel Alkaloids

Daurisoline is a hERG inhibitor and also an autophagy blocker.

HY-N0095

(S)-10-Hydroxycamptothecin 10-HCPT; 10-Hydroxycamptothecin	Topoisomerase Apoptosis	Alkaloids
(S)-10-Hydroxycamptothecin (10-HCPT;10-Hydroxycamptothecin) is a DNA topoisomerase I inhibitor of isolated from the Chinese plant Camptotheca accuminata. (S)-10-Hydroxycamptothecin exhibits a remarkable apoptosis-inducing effect. (S)-10-Hydroxycamptothecin has the potential for hepatoma, gastric carcinoma, colon cancer and leukaemia treatment.

HY-15494

Picropodophyllin AXL1717; Picropodophyllin; PPP	IGF-1R Apoptosis	Phenylpropanoids
Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC₅₀ of 1 nM.

HY-N3298

Meranzin	Adrenergic Receptor	Natural Products
Meranzin is an absorbed bioactive compound from the Traditional Chinese Medicine (TCM) Chaihu-Shugan-San (CSS). Meranzin, isolated from leaves of Murraya exotica L., regulates the shared alpha 2-adrenoceptor and involves the AMPA-ERK1/2–BDNF signaling pathway. Meranzin has the potential for the prevention of the comorbidity of atherosclerosis and depression.

HY-B1790

Terconazole
R42470
Fungal Natural Products

Terconazole is a broad-spectrum antifungal medication for the treatment of vaginal yeast infection.

HY-N5056

DL-Goitrin	Others	Natural Products
DL-Goitrin, also called (R, S)- report by the spring, consists of the epigoitrin (reported by the R- Spring) and the spring (-S- reported by spring), and the two mutually isomers, and the mixture is the ingredient of Radix.

HY-116330A

Hyperforin dicyclohexylammonium salt Hyperforin DCHA	TRP Channel Calcium Channel	Natural Products
Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin dicyclohexylammonium salt modulates Ca²⁺ levels by activating Ca²⁺-conducting non-selective canonical TRPC6 channels. Hyperforin dicyclohexylammonium salt shows antidepressant effect.

HY-N0898A

(-)-Catechin (-)-Cianidanol; (-)-Catechuic acid	COX	Flavonoids
(-)-Catechin, isolated from green tea, is an isomer of Catechin having a trans 2S,3R configuration at the chiral center. Catechin inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 1.4 μM.

HY-A0124A

Sapropterin dihydrochloride 6R-BH4 dihydrochloride; 6R-Tetrahydro-L-biopterin dihydrochloride	Others	Alkaloids
Sapropterin dihydrochloride is a synthetic form of BH4 that is approved for the treatment of BH4 responsive PKU.

HY-13520

Nocodazole Oncodazole; R17934	Microtubule/Tubulin Bcr-Abl CRISPR/Cas9 Autophagy Apoptosis	Natural Products
Nocodazole is a rapidly-reversible inhibitor of microtubule. Nocodazole binds to β-tubulin and disrupts microtubule assembly/disassembly dynamics, which prevents mitosis and induces apoptosis in tumor cells. Nocodazole inhibits Bcr-Abl, and activates CRISPR/Cas9.

HY-Y0378

D-Leucine (R)-Leucine	Endogenous Metabolite	Acids and Aldehydes
D-Leucine is a more potent anti-seizure agent than L-leucine. D-leucine potently terminates seizures even after the onset of seizure activity. D-leucine, but not L-leucine, reduces long-term potentiation but had no effect on basal synaptic transmission in vitro.

HY-N0596

Panaxadiol
20(R)-Panaxadiol
Others Terpenoids and Glycosides

Panaxadiol is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.
HY-N6629

3'-Methoxyflavonol
Others Flavonoids

3'-Methoxyflavonol is a selective agonist of neuromedin U 2 receptor (NMU2R).

HY-N0328

alpha-Mangostin α-Mangostin	Reactive Oxygen Species Apoptosis Bacterial Fungal Virus Protease	Natural Products
alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a K_i of 2.85 μM.

HY-N4267

Yangambin	Calcium Channel	Phenylpropanoids
Yangambin, a furofuran lignan, is already isolated from plants such as member of the Annonaceae family, including species of the genus Rollinia: R. pickeli, R. exalbidaand R. mucosa, as well from the Magnolia biondii. Yangambin, a selective PAF receptor antagonist, inhibits Ca²⁺ influx through voltage-gated Ca²⁺ channels, leading to the reduction in [Ca²⁺]i in vascular smooth muscle cells and consequent peripheral vasodilation. Yangambin exhibits the antiallergic activity against β-hexosaminidase release with an IC₅₀ of 33.8 μM and for anti-inflammatory activity with an IC₅₀ of 37.4 μM.

HY-N0507

Rosavin
Others Terpenoids and Glycosides

Rosavin is isolated from R. rosea, Rosavin shows antidepressant-like, adaptogenic, anxiolytic-like effects in mice model.

HY-N2084

Perillartine DL-Perillartine	Endogenous Metabolite	Natural Products
Perillartine is a sweetener, which activates the taste receptor type 1 member 2 (Tas1r2) subunit in a species-dependent manner.

HY-B1173

(+)-Camphor
D-(+)-Camphor; (1R)-(+)-Camphor
Bacterial Terpenoids and Glycosides

(+)-Camphor is an ingredient in cooking, and as an embalming fluid for medicinal purposes,
HY-100805

D-Glutamic acid
(R)-Glutamic acid
Endogenous Metabolite Acids and Aldehydes

D-glutamic acid, an enantiomer of L- glutamic acid, is widely used in pharmaceuticals and foods.

HY-P0201

Substance P Neurokinin P	Neurokinin Receptor Endogenous Metabolite	Natural Products
Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, *NK1R*).

HY-111095

D-(-)-Lactic acid (R)-2-Hydroxypropionic acid	Endogenous Metabolite	Acids and Aldehydes
D-(-)-Lactic acid is a normal intermediate in the fermentation (oxidation, metabolism) of sugar. D-(-)-Lactic acid is identified to be a competitive inhibitor of ProDH (proline dehydrogenase) in plants.

HY-B0751

Fumagillin Amebacilin; NSC9168	Parasite HIV Antibiotic	Natural Products
Fumagillin(NSC9168) is a complex biomolecule and used as an antimicrobial agent. Fumagillin can inhibits HIV‐1 infection through the inhibition of HIV-1 viral protein R (Vpr) activity.

HY-42068

(-)-Aspartic acid
(R)-Aspartic acid; D-(-)-Aspartic acid
Endogenous Metabolite iGluR Alkaloids Antibiotics

(-)-Aspartic acid is an endogenous NMDA receptor agonist.
HY-N1459

Campesterol
(24R)-5-Ergosten-3β-ol
Endogenous Metabolite Steroids

Campesterol is a plant sterol with cholesterol lowering and anticarcinogenic effects.

HY-Y0152

Cinchonine (8R,9S)-Cinchonine; LA40221	Apoptosis Parasite	Alkaloids
Cinchonine is a natural compound present in Cinchona bark. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells.

HY-32343

Secalciferol (24R)-24,25-Dihydroxyvitamin D3	VD/VDR Endogenous Metabolite	Natural Products
Secalciferol is a metabolite of Vitamin D, a possibly anti-inflammatory steroid which is involved in bone ossification.

HY-128720

Diethyl oxalpropionate	Endogenous Metabolite	Natural Products
Diethyl oxalpropionate is an intermediate for poly((R,S)-3,3-dimethylmalic acid) (PDMMLA) derivative synthesis. PDMMLA derivative can be used in synthesis of nanoparticles and study of warfarin encapsulation and controlled release.

HY-N3199

Neorauflavene	Bacterial	Phenols
Neorauflavene is a phenolic neorautanenia isoflavanoid isolated from Neorautanenia edulis. Neorauflavene shows antibacterial activities against *E. faecalis, S. suis, S. agalactiae, P. aeruginosa, B. subtilis, and R. anatipestifer*.

HY-N2000

Bellidifolin	HIV	Natural Products
Bellidifolin is a xanthone isolated from the stems of Swertia punicea, with hepatoprotective, hypoglycemic, anti-oxidation, anti-inflammatory and antitumor activities. Bellidifolin also acts as a viral protein R (Vpr) inhibitor.

HY-N2566

Euscaphic acid	DNA/RNA Synthesis PI3K Apoptosis	Terpenoids and Glycosides
Euscaphic acid, a DNA polymerase inhibitor, is a triterpene from the root of the R. alceaefolius Poir. Euscaphic inhibits calf DNA polymerase α (pol α) and rat DNA polymerase β (pol β) with IC₅₀ values of 61 and 108 μM. Euscaphic acid induces apoptosis.

HY-116474

Viridicatol	Fungal	Alkaloids
Viridicatol, a quinolinone alkaloid, is isolated from the fermentation of an endophytic fungus Penicillium sp. R22 in Nerium indicum. Viridicatol has strong antifungal activity against Staphylococcus aureus with MIC value of 15.6 μg/mL.

HY-12686

5Z-7-Oxozeaenol FR148083; L783279; LL-Z 1640-2	MAP3K VEGFR	Natural Products
5Z-7-Oxozeaenol is a natural anti-protozoan compound from fungal origin, acting as a potent irreversible and selective inhibitor of TAK1 and *VEGF-R2, with IC₅₀*s of 8 nM and 52 nM, respectively.

HY-129997

Luteolinidin chloride	Others	Flavonoids
Luteolinidin is a natural deoxyanthocyanidin, isolated from mosses and ferns. Luteolinidin is a potent CD38 inhibitor which can protect the heart against I/R injury with preservation of eNOS function and prevention of endothelial dysfunction in vivo.

HY-N1353

Rhamnocitrin	Others	Flavonoids
Rhamnocitrin is a flavonoid isolated from astragalus complanatus R. Br. (Sha-yuan-zi). Rhamnocitrin is a scavenger of DPPH with an IC₅₀ of 28.38 mM. Rhamnocitrin has anti-oxidant, anti-inflammatory and an-tiatherosclerosis activity.

HY-B0927

Hydrastine (-)-β-Hydrastine; (1R,9S)-β-Hydrastine	Others	Alkaloids
Hydrastine is a natural alkaloid which is present in Hydrastis canadensis and other plants of the ranunculaceae family.

HY-B1194

Tetramisole hydrochloride (±)-Tetramisole hydrochloride; DL-Tetramisole hydrochloride; R-829	Parasite Phosphatase Antibiotic	Natural Products
Tetramisole hydrochloride is an inhibitor of alkaline phosphatases, is a high purity antiparasitic.

HY-I1060

L-Alloisoleucine (3R)-LS-Isoleucine; L-Allo-isoleucine	Endogenous Metabolite	Natural Products
L-Alloisoleucine is a branched chain amino acid and is a stereo-isomer of L-isoleucine. L-Alloisoleucine is a common constituent of human plasma (albeit at low levels).

HY-107608

Leukotriene B4 LTB4; 5(S),12(R)-DiHETE	PROTAC Linker Endogenous Metabolite	Acids and Aldehydes
Leukotriene B4 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-41700

D-Alanine (R)-Alanine; Ba 2776; D-α-Alanine	Endogenous Metabolite	Alkaloids Acids and Aldehydes
D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC₅₀ of 9 mM for GlyR.

HY-N7539

Cognac oil	Others	Natural Products
Cognac oil, mainly found in wine lees, has unique fatty acid profiles, including Palmitic acid (59.26%), Linoleic acid (11.92%), Myristic acid (8.97%), Oleic acid (8.3%) and other fatty acids. Cognac oil leads to a general increase in the permeation of R6G (Rhodamine 6G) across all the membranes.

HY-N2273

Gymnestrogenin	LXR	Terpenoids and Glycosides
Gymnestrogenin is a pentahydroxytriterpene from the leaves of Gymnema sylvestre R.Br. Gymnestrogenin is a LXR antagonist with IC₅₀s of 2.5 and 1.4 μM for LXRα and LXRβ transactivation, respectively. Gymnestrogenin reduces the transcriptional activity of LXR even on its own promoter, thus reducing the mRNA expression.

HY-N6972

Cepharanthine	HIV Autophagy Apoptosis	Alkaloids
Cepharanthine, an alkaloid derived from Stephania cepharantha Hayata, with possesses anti-inflammatory and antioxidative activities. Cepharanthine attenuates muscle and kidney injuries induced by limb ischemia/reperfusion (I/R). Cepharanthine induces autophagy, apoptosis and cell cycle arrest in breast cancer cells. Cepharanthine inhibits the HIV-1 entry process by reducing plasma membrane fluidity.

HY-12545

Brevetoxin-3 PbTx-3	Sodium Channel	Natural Products
Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na⁺ channel activator and has multiple active centers (A-ring lactone, C-42 of R side chain). Brevetoxin-3 (PbTx-3) has a high affinity to site 5 of the voltage-sensitive Na⁺ channels, inhibits the inactivation of Na⁺ channels and prolongs the mean open time of these channels. Brevetoxin-3 (PbTx-3) repeated exposures can lead to prolonged airway hyperresponsiveness (AHR) and lung inflammation.

HY-W040055

D-(+)-Neopterin 2-Amino-6-((1S,2R)-1,2,3-trihydroxypropyl)pteridin-4(3H)-one	Endogenous Metabolite	Saccharides and Glycosides
D-(+)-Neopterin, a catabolic product of guanosine triphosphate (GTM), serves as a marker of cellular immune system activation.

HY-N0408

Picroside II	NF-κB Reactive Oxygen Species Apoptosis Influenza Virus	Saccharides and Glycosides Terpenoids and Glycosides
Picroside II, an iridoid compound extracted from Picrorhiza, exhibits anti-inflammatory and anti-apoptotic activities. picroside II alleviates the inflammatory response in sepsis and enhances immune function by inhibiting the activation of NLRP3 inflammasome and NF-κB pathways. Picroside II is an antioxidant, exhibits a significant neuroprotective effect through reducing ROS production and protects the blood-brain barrier (BBB) after cerebral ischemia-reperfusion (CI/R) injury. Picroside II has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities.

Cat. No.	Product Name	Species	Source

HY-P7579

Recombinant Human CSF1R Protein (CHO-expressed) rHuCSF1R Protein; Macrophage colony-stimulating factor 1 receptor; CSF-1 receptor; CSF-1-R; CSF-1R; M-CSF-R; Proto-oncogene c-Fms; CD115; CSF1R; FMS	Human	CHO

HY-P7223

Recombinant Human Interleukin-6 Receptor (CHO-expressed) rHuIL-6R; IL-6RA; IL-6R 1; CD126; Membrane glycoprotein 80	Human	CHO
Recombinant Human Interleukin-6 Receptor (CHO-expressed) is responsible for signal transduction of Interleukin-6 that might have associations with immune disease and various infectious diseases.

HY-P7220

Recombinant Human Interleukin-4 Receptor (HEK293-expressed) rHuIL-4R; IL4R; IL-4RA; CD124	Human	HEK 293
Recombinant Human Interleukin-4 Receptor (HEK293-expressed) is a type I transmembrane protein that can bind interleukin-4 and interleukin-13.

HY-P7559

Recombinant Human Interleukin-4 Receptor (CHO-expressed) rHuIL-4R; Interleukin-4 receptor subunit alpha; IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; CD124; IL-4 receptor subunit alpha; IL-4R-alph; sIL4Ralpha/prot; IL-4-binding protein; IL4-BP; IL4R; IL4RA	Human	CHO
Recombinant Human Interleukin-4 Receptor (CHO-expressed) is a CHO cell derived type I transmembrane protein that can bind interleukin-4 and interleukin-13^[1].

HY-P7597

Recombinant Human IL-17RA/IL-17R Protein (CHO-expressed)
rHuIL-17RA/IL-17R Protein (CHO-expressed); Interleukin-17 receptor A; IL-17 receptor A; IL-17RA; CDw217; CD217; IL17RA; IL17R
Human CHO
HY-P7130

Recombinant Human BAFF Receptor
rHuBAFF-R; CD268; TNFRSF13C; BR3
Human E. coli

Recombinant Human BAFF Receptor is a TNF Receptor that specifically interacts with BAFF.

HY-P7374

Recombinant Human Interleukin-2 Receptor alpha/CD25, Fc Chimera (HEK293-expressed) rHuIL-2R α/CD25, Fc Chimera; TAC antigen; IL-2-RA; IL-2 R alpha; IL-2Rα; IL2RA	Human	HEK 293
Recombinant Human Interleukin-2 Receptor alpha/CD25, Fc Chimera (HEK293-expressed) is a subunit of interleukin-2 receptor, plays a critical role in regulating the IL-2-mediated responses by modulating the affinity of the IL-2R for the ligand.

HY-P7114

Recombinant Human R-spondin-1/RSPO1
rHuR-spondin-1/RSPO1; Roof plate-specific spondin-1
Human CHO

Recombinant Human R-spondin-1/RSPO1 is a secreted protein that activates Wnt signaling.

HY-P7221

Recombinant Human Interleukin-5 Receptor alpha (CHO-expressed) rHuIL-5Rα; IL-5R; IL-5RA; CD125	Human	CHO
Recombinant Human Interleukin-5 Receptor alpha (CHO-expressed) is a subunit of the Interleukin-5 receptor.

HY-P7563

Recombinant Human Interleukin-2 Receptor alpha/CD25 (CHO-expressed) rHuIL-2R α/CD25; Interleukin-2 receptor subunit alpha; IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2-RA; TAC antigen; p55; CD25; IL2RA	Human	CHO

HY-P7229

Recombinant Human I-TAC/CXCL11 rHuI-TAC/CXCL11; C-X-C motif chemokine 11; Beta-R1; H174; IP-9; SCYB11	Human	E. coli
Recombinant Human I-TAC/CXCL11 is a small cytokine belonging to the CXC chemokine family which can be strongly induced by IFN-gamma, and its receptor CXCR3.

HY-P7228

Recombinant Human I-TAC/CXCL11 (HEK293-expressed) rHuI-TAC/CXCL11; C-X-C motif chemokine 11; Beta-R1; H174; IP-9; SCYB11	Human	HEK 293
Recombinant Human I-TAC/CXCL11 (HEK293-expressed) is a small cytokine belonging to the CXC chemokine family which can be strongly induced by IFN-gamma, and its receptor CXCR3.

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