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Results for "

AP-5

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Free Fatty Acid Receptor (2) iGluR (3) MicroRNA (4) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (1) Inflammation/Immunology (1) Metabolic Disease (2) Neurological Disease (3)

Inhibitors & Agonists

Targets Recommended: AP-1 AAK1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

DL-AP5 2-APV; DL-2-Amino-5-phosphonovaleric acid
DL-AP5 (2-APV) is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 shows significantly antinociceptive activity. DL-AP5 specifically blocks on channels in the rabbit retina .

*AP5*	Free Fatty Acid Receptor	Metabolic Disease
AP5 is a potent, orlly active, and selective GPR40 receptor agonist with a positive allosteric modulation of endogenous ligand (AgoPAM). AP5 demonstrates rat and human inositol monophosphate (IP1) EC₅₀ values of 0.49 nM and 0.8 nM against the GPR40 receptor, respectively. AP5 has the potential for type II diabetes research .

AP5 sodium	Free Fatty Acid Receptor	Metabolic Disease
AP5 sodium is a potent, orall active, and selective GPR40 receptor agonist with a positive allosteric modulation of endogenous ligand (AgoPAM). AP5 sodium demonstrates rat and human inositol monophosphate (IP1) EC₅₀ values of 0.49 nM and 0.8 nM against the GPR40 receptor, respectively. AP5 sodium has the potential for type II diabetes research .

AP5Z1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
AP5Z1 Human Pre-designed siRNA Set A contains three designed siRNAs for AP5Z1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AP5Z1 Human Pre-designed siRNA Set A AP5Z1 Human Pre-designed siRNA Set A

*DL-AP5* sodium** 2-APV sodium; DL-2-Amino-5-phosphonovaleric acid sodium	iGluR	Neurological Disease Inflammation/Immunology
DL-AP5 (2-APV) sodium is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 sodium shows significantly antinociceptive activity. DL-AP5 sodium specifically blocks on channels in the rabbit retina .

L-AP5 L-APV; L-2-Amino-5-phosphonovaleric acid	iGluR	Neurological Disease
L-AP5 (L-APV; L-2-Amino-5-phosphonovaleric acid) is an NMDA antagonist and is the isomer of D-AP5 (HY-100714A). L-AP5 shows a relatively weak amino acid and synaptic blocking activity .

D-AP5 Maximum Cited Publications 16 Publications Verification D-APV; D-2-Amino-5-phosphonovaleric acid	iGluR	Neurological Disease
D-AP5 (D-APV) is a selective and competitive NMDA receptor antagonist with a K_d of 1.4 μM. D-AP5 (D-APV) inhibits the glutamate binding site of NMDA receptors .

hsa-miR-548ap-5p mimic	MicroRNA	Cancer
hsa-miR-548ap-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-548ap-5p mimic hsa-miR-548ap-5p mimic

hsa-miR-548ap-5p inhibitor	MicroRNA
hsa-miR-548ap-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-548ap-5p inhibitor hsa-miR-548ap-5p inhibitor

hsa-miR-548ap-5p agomir	MicroRNA
hsa-miR-548ap-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-548ap-5p agomir hsa-miR-548ap-5p agomir

hsa-miR-548ap-5p antagomir	MicroRNA
hsa-miR-548ap-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-548ap-5p antagomir hsa-miR-548ap-5p antagomir

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