Search Result

Results for "

APCs

" in MCE Product Catalog:

By Targets:	APC (5) Apoptosis (1) Cholinesterase (ChE) (1) Complement System (1) Fluorescent Dye (2) Ligands for Target Protein for PROTAC (1) Liposome (1) NOD-like Receptor (NLR) (1) Ser/Thr Protease (3) Topoisomerase (1) Wnt (1)
By Research Areas:	Cancer (16) Cardiovascular Disease (2) Inflammation/Immunology (4) Metabolic Disease (2)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Targets Recommended: APC

Cat. No.	Product Name	Target	Research Areas

HY-108442

JW67	Wnt	Cancer
JW67 inhibits the canonical Wnt signaling with an IC₅₀ of 1.17μM. JW67 affects the multiprotein complex consisting of β-catenin/GSK-3β/AXIN/APC/CK1 that rapidly reduces active β-catenin with a subsequent downregulation of Wnt target genes. JW67 also inhibits colorectal cancer cell growth.

HY-101092

QS-21 Stimulon	NOD-like Receptor (NLR)	Inflammation/Immunology Cancer
QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18.

HY-13255A

TAME hydrochloride	APC	Cancer
TAME hydrochloride is an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC), which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest. TAME hydrochloride is not cell permeable.

HY-114015

APC-6860	Ser/Thr Protease	Cancer
APC-6860 is a trypsin-like serine proteases inhibitor with k_i values of 0.21 and 0.44 μM for uPA and trypsin, respectively. APC-6860 has a selectivity ratio for tPA versus uPA of 80. APC-6860 has k_i values of 0.1 and 0.082 μM for human and murine urokinases, respectively. APC-6860 can be used for the research of cancer.

HY-138064

*4-APC* hydrobromide**	Others	Others
4-APC hydrobromide is a highly sensitive and selective derivatization agent for aldehydes. 4-APC hydrobromide possesses an aniline moiety for a fast selective reaction with aliphatic aldehydes as well as a quaternary ammonium group for improved MS sensitivity. 4-APC hydrobromide allows highly sensitive and selective MS detection of aldehydes.

HY-13255

TAME	APC	Cancer
TAME is an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC), which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest. TAME is not cell permeable.

HY-116572A

TASIN-1	Others	Cancer
TASIN-1 is a selective inhibitor of truncated *APC* gene (adenomatous polyposis coli gene) and exerts cytotoxic effects through inhibition of cholesterol biosynthesis. TASIN-1 represents a potential therapeutic strategy for prevention and intervention in CRC with mutant APC.

HY-105999B

APC 366 TFA

Others Others

APC 366 (TFA) is an irreversible mast cell tryptase inhibitor. APC 366 (TFA) can be used for the research of allergic diseases.

APC 366 TFA	Others	Others
APC 366 (TFA) is an irreversible mast cell tryptase inhibitor. APC 366 (TFA) can be used for the research of allergic diseases.

HY-103255

CFM-4	Apoptosis	Cancer
CFM-4 is a potent small molecular antagonist of CARP-1/APC-2 binding. CFM-4 prevents CARP-1 binding with APC-2, causes G₂M cell cycle arrest, and induces apoptosis with an IC₅₀ range of 10-15 μM. CFM-4 also suppresses growth of drug-resistant human breast cancer cells.

HY-105999

APC 366	Ser/Thr Protease	Inflammation/Immunology
APC 366 is a selective inhibitor of mast cell tryptase (K_i=7.1 μM). APC 366 inhibits antigen-induced early asthmatic response (EAR), late asthmatic response (LAR), and bronchial hyperresponsiveness (BHR) in a sheep model of allergic asthma.

HY-P0021

D-Lys(Z)-Pro-Arg-pNA

Chromozym Pca
Fluorescent Dye Others

D-Lys(Z)-Pro-Arg-pNA (Chromozym Pca) is a luminescent substrate of activated protein C (APC).

D-Lys(Z)-Pro-Arg-pNA Chromozym Pca	Fluorescent Dye	Others
D-Lys(Z)-Pro-Arg-pNA (Chromozym Pca) is a luminescent substrate of activated protein C (APC).

HY-110287

Apcin 3 Publications Verification	APC	Cancer
Apcin, a ligand of Cdc20, is a potent and competitive anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity inhibitor. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substrate recognition. Apcin occupes the D-box-binding pocket on the side face of the WD40-domain and can prolong mitosis.

HY-124955

proTAME 1 Publications Verification	APC	Cancer
proTAME, a cell-permeable proagent form of TAME, is an anaphase promoting complex/cyclosome (APC/C) inhibitor. proTAME causes cell cycle arrest in metaphase.

HY-153538

AP-C2

Ser/Thr Protease Metabolic Disease

AP-C2 is a potent guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) inhibitor with a pIC₅₀ of 5.2.

AP-C2	Ser/Thr Protease	Metabolic Disease
AP-C2 is a potent guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) inhibitor with a pIC₅₀ of 5.2.

HY-130841

Apcin-A	APC Ligands for Target Protein for PROTAC	Cancer
Apcin-A, an Apcin derivative, is an anaphase-promoting complex (APC) inhibitor. Apcin-A interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A can be used to synthesize the PROTAC CP5V (HY-130257).

HY-130530

AP-C5	Others	Metabolic Disease
AP-C5 displays selective inhibition of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC₅₀ of 7.2, which can be used for the research of diarrheal disease.

HY-100620

RPR121056 APC	Topoisomerase Cholinesterase (ChE)	Cancer
RPR121056 (APC) is a metabolite of Irinotecan (CPT-11), which is generated by CYP3A4. Irinotecan (CPT-11) is an antineoplastic agent that inhibits topoisomerase type I, causing cell death, and is widely used in the treatment of colorectal cancer. Irinotecan also directly inhibits AChE.

HY-D1815

Allophycocyanin 1 Publications Verification APC Dye	Fluorescent Dye	Others
Allophycocyanin (APC Dye) is a light-harvesting protein, containing strongly coupled dimers of chromophores. Allophycocyanin serve as a minimal system to examine photosynthetic energy transfer. Allophycocyanin strongly absorbs far-red light (FRL), and expresses during acclimation to low light, likely associates with chlorophyll a-containing photosystem I.

HY-112956

Drotrecogin alfa (activated)	Others	Inflammation/Immunology
Drotrecogin alfa activated (DrotAA) is recombinant human activated protein C (APC). Drotrecogin alfa activated prevents smoke-induced increases in pulmonary microvascular permeability and proinflammatory cytokine IL-1β in rats. Drotrecogin alfa activated inhibits coagulation and inflammation and promotes fibrinolysis. Drotrecogin alfa activated can be used for severe sepsis reaearch.

HY-117930

Danicopan 2 Publications Verification ACH-4471	Complement System	Inflammation/Immunology
Danicopan (ACH-4471), a selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with K_d value of 0.54 nM. Danicopan (ACH-4471) inhibits alternative pathway of complement (APC) activity, has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS).

HY-112758

DLin-KC2-DMA 2 Publications Verification	Liposome	Others
DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6) that is virtually non-toxic to antigen presenting cells (APCs). DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies.

HY-145414

DYSP-C34	Others	Cancer
DYSP-C34 is a potent, biocompatible, and ultrasound (US)-triggered multifunctional molecular machine. DYSP-C34 has multiple favorable properties, such as improved lipophilic/hydrophilic balance, intensified US-induced ROS production capacity, and better cellular permeability, resulting in the excellent tumor target efficiency and notable sonodynamic therapy (SDT)-mediated tumor regression. DYSP-C34 exhibits mild immunogenicity by stimulating APCs directly.

HY-151509

A2-Iso5-2DC18	Others	Cancer
A2-Iso5-2DC18 is a dihydroimidazole-linked lipid, served as potent mRNA delivery vehicle. A2-Iso5-2DC18 can be used for antitumor research, including B16F10 melanoma..

Cat. No.	Product Name	Type

HY-D1815

Allophycocyanin 1 Publications Verification APC Dye	Dyes
Allophycocyanin (APC Dye) is a light-harvesting protein, containing strongly coupled dimers of chromophores. Allophycocyanin serve as a minimal system to examine photosynthetic energy transfer. Allophycocyanin strongly absorbs far-red light (FRL), and expresses during acclimation to low light, likely associates with chlorophyll a-containing photosystem I.

HY-P0021

D-Lys(Z)-Pro-Arg-pNA

Chromozym Pca
Chromogenic Substrates

D-Lys(Z)-Pro-Arg-pNA (Chromozym Pca) is a luminescent substrate of activated protein C (APC).

D-Lys(Z)-Pro-Arg-pNA Chromozym Pca	Chromogenic Substrates
D-Lys(Z)-Pro-Arg-pNA (Chromozym Pca) is a luminescent substrate of activated protein C (APC).

Cat. No.	Product Name	Target	Research Area

HY-P1918

Activated Protein C (390-404), human 4 Publications Verification	Peptides	Cardiovascular Disease
Activated Protein C (390-404), human is a peptide of the activated protein C (a vitamin K-dependent serine protease), potently inhibits APC anticoagulant activity.

HY-P2269

MAIT-203	Peptides	Cancer
MAIT-203, a cyclopentyalanin-derived peptidomimetic, potently inhibits the interaction of adenomatous polyposis coli (APC) and Asef (RhoGEF4), but not APC-Sam68 or APC-striatin interactions. MAIT-203 binds APC-ARM with a K_i of 0.015 μM and a K_d of 0.036 μM. MAIT-203 significantly represses the migration and invasion of colorectal cancer cells.

HY-P0021

D-Lys(Z)-Pro-Arg-pNA

Chromozym Pca
Fluorescent Dye Others

D-Lys(Z)-Pro-Arg-pNA (Chromozym Pca) is a luminescent substrate of activated protein C (APC).

D-Lys(Z)-Pro-Arg-pNA Chromozym Pca	Fluorescent Dye	Others
D-Lys(Z)-Pro-Arg-pNA (Chromozym Pca) is a luminescent substrate of activated protein C (APC).

HY-P1918A

Activated Protein C (390-404), human TFA	Peptides	Cardiovascular Disease
Activated Protein C (390-404), human TFA, a peptide of the activated protein C (a vitamin K-dependent serine protease), potently inhibits APC anticoagulant activity.

Cat. No.	Product Name	Target	Research Area

HY-P99603

Cifurtilimab SEA-CD40	Inhibitory Antibodies	Cancer
Cifurtilimab (SEA-CD40) is an agonistic nonfucosylated, humanized IgG1 monoclonal antibody directed against CD40. Cifurtilimab shows antitumor activities.

HY-P99933

Eftilagimod alfa IMP321; LAG-3Ig	Inhibitory Antibodies	Cancer
Eftilagimod alfa (IMP321) is a recombinant LAG-3Ig fusion protein that binds to MHC class II. Eftilagimod alfa mediates antigen-presenting cell (APC) activation followed by CD8 T-cell activation. Eftilagimod alfa can be used for metastatic melanoma and metastatic breast carcinoma research.

Cat. No.	Product Name	Target	Category

HY-101092

QS-21 Stimulon	NOD-like Receptor (NLR)	Triterpenes Terpenoids Structural Classification other families Plants Source classification Inflammation/Immunology Disease Research Fields Classification of Application Fields
QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18.

Species:	Human (1) Mouse (2) Rat (1)
Tag:	His (3) Fc (1)
Source:	HEK293 (4)

Cat. No.	Product Name	Species	Source

HY-P78345

Pentraxin 2/SAP Protein, Mouse (HEK293, Fc)

SAP; APCs; MGC88159; Pentraxin 2; PTX2
Mouse HEK293
HY-P71111

Pentraxin 2/SAP Protein, Mouse (HEK293, His)

APCs; PTX2; SAP; 9.5S alpha-1-glycoprotein; Serum amyloid P; MGC88159; PTX2serum amyloid P-component; SAP pentaxin-related
Mouse HEK293
HY-P71067

Pentraxin 2/SAP Protein, Human (HEK293, His)

Serum Amyloid P-Component; SAP; 9.5S Alpha-1-Glycoprotein; APCs; PTX2
Human HEK293
HY-P73715

Pentraxin 2/SAP Protein, Rat (HEK293, His)

Serum amyloid P-component; SAP; APCs; Ptx2
Rat HEK293

APCs

Inhibitors & Agonists

Fluorescent Dye

Peptides

Inhibitory Antibodies

NaturalProducts

Recombinant Proteins

Natural
Products