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APOE

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Bacterial (1) c-Myc (1) Fatty Acid Synthase (FASN) (1) GCGR (1) JNK (1) LXR (2) MEK (1) MMP (1) nAChR (2) PPAR (1) Sirtuin (2) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (5) Metabolic Disease (2) Neurological Disease (4)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1050A

COG 133 TFA 1 Publications Verification	nAChR	Neurological Disease Inflammation/Immunology
COG 133 TFA is a fragment of Apolipoprotein E (APOE) peptide. COG 133 TFA competes with the ApoE holoprotein for binding the LDL receptor, with potent anti-inflammatory and neuroprotective effects. COG 133 TFA is also a nAChR antagonist with an IC₅₀ of 445 nM .

HY-103076

EZ-482 1 Publications Verification	Others	Neurological Disease
EZ-482, a novel ligand of apolipoprotein (apoE), binds to sites on apoE in the C-terminal domain with K_ds of 5-10 μM for apoE3 and apoE4. EZ-482 binds to apoE4 by a unique N-terminal allosteric effect. EZ482 has the potential for Alzheimer’s diseas .

HY-RS00849

APOE Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
APOE Human Pre-designed siRNA Set A contains three designed siRNAs for APOE gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

APOE Human Pre-designed siRNA Set A APOE Human Pre-designed siRNA Set A

HY-RS00850

Apoe Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Apoe Mouse Pre-designed siRNA Set A contains three designed siRNAs for Apoe gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Apoe Mouse Pre-designed siRNA Set A Apoe Mouse Pre-designed siRNA Set A

HY-P1050

COG 133	nAChR	Neurological Disease Inflammation/Immunology
COG 133 is a fragment of Apolipoprotein E (APOE) peptide. COG 133 competes with the ApoE holoprotein for binding the LDL receptor, with potent anti-inflammatory and neuroprotective effects. COG 133 is also a nAChR antagonist with an IC₅₀ of 445 nM .

HY-111498

RGX-104 hydrochloride 1 Publications Verification Abequolixron hydrochloride	LXR	Inflammation/Immunology Cancer
RGX-104 hydrochloride is a small-molecule LXR agonist that modulates innate immunity via transcriptional activation of the ApoE gene.

HY-111498A

RGX-104 1 Publications Verification Abequolixron	LXR	Inflammation/Immunology Cancer
RGX-104 is an orally bioavailable and potent liver-X nuclear hormone receptor (LXR) agonist that modulates innate immunity via transcriptional activation of the ApoE gene.

HY-P0119

Lixisenatide 1 Publications Verification	GCGR MEK Akt MMP JNK	Neurological Disease Metabolic Disease Inflammation/Immunology
Lixisenatide is a GLP-1 receptor agonist. Lixisenatide inhibits the inflammatory response through down regulation of proinflammatory cytokines, and blocks of cellular signaling pathways. Lixisenatide decreases atheroma plaque size and instability in Apoe ^−/− Irs ^2+/− mice by reprogramming macrophages towards an M2 phenotype, which leads to reduced inflammation .

HY-117006

E1231 1-{4-[2-(5-Methylfuran-2-yl)quinoline-4-carbonyl]piperazin-1-yl}ethan-1-one	Sirtuin	Cardiovascular Disease
E1231 is an orally active activator of Sirtuin 1 (SIRT1) (EC₅₀=0.83 μM), to modulate cholesterol and lipid metabolism. E1231 interactes with SIRT1 (K_D=9.61 μM) and deacetylated liver X receptor-alpha (LXRα), and increases ATP-binding cassette transporter A1 (ABCA1) expression. E1231 also reduces atherosclerotic plaque development in ApoE ^-/- mice model. E1231 can be used for research in cholesterol and lipid disorder-related diseases .

HY-N0704

Agrimol B	Sirtuin PPAR Fatty Acid Synthase (FASN) c-Myc Bacterial	Infection Metabolic Disease Cancer
Agrimol B, a polyphenol, is an orally active and potent SIRT1 activator. Agrimol B shows anti-adipogenic and anticancer activity. Agrimol B shows antibacterial activity against plant pathogens. Agrimol B dramatically inhibits 3T3-L1 adipocyte differentiation by reducing PPARγ, C/EBPα, FAS, UCP-1, and *apoE* expression. The action of Agrimol B on the cancer cells is likely derived from its effect on c-MYC, SKP2 and p27 .

Cat. No.	Product Name	Target	Research Area

HY-P1050A

COG 133 TFA 1 Publications Verification	nAChR	Neurological Disease Inflammation/Immunology
COG 133 TFA is a fragment of Apolipoprotein E (APOE) peptide. COG 133 TFA competes with the ApoE holoprotein for binding the LDL receptor, with potent anti-inflammatory and neuroprotective effects. COG 133 TFA is also a nAChR antagonist with an IC₅₀ of 445 nM .

HY-P0119

Lixisenatide 1 Publications Verification	GCGR MEK Akt MMP JNK	Neurological Disease Metabolic Disease Inflammation/Immunology
Lixisenatide is a GLP-1 receptor agonist. Lixisenatide inhibits the inflammatory response through down regulation of proinflammatory cytokines, and blocks of cellular signaling pathways. Lixisenatide decreases atheroma plaque size and instability in Apoe ^−/− Irs ^2+/− mice by reprogramming macrophages towards an M2 phenotype, which leads to reduced inflammation .

Agrimol B	Agrimonia pilosa Ledeb. Structural Classification Classification of Application Fields Rosaceae Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	Sirtuin PPAR Fatty Acid Synthase (FASN) c-Myc Bacterial
Agrimol B, a polyphenol, is an orally active and potent SIRT1 activator. Agrimol B shows anti-adipogenic and anticancer activity. Agrimol B shows antibacterial activity against plant pathogens. Agrimol B dramatically inhibits 3T3-L1 adipocyte differentiation by reducing PPARγ, C/EBPα, FAS, UCP-1, and *apoE* expression. The action of Agrimol B on the cancer cells is likely derived from its effect on c-MYC, SKP2 and p27 .

Species:	Human (7) Mouse (2) Rat (1) Rabbit (2)
Tag:	His (9) SUMO (1) Myc (1) Fc (3) B2M (1)
Source:	HEK293 (9) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P701094

	*Apolipoprotein E/APOE2 Protein, Human (R154S, R176C, HEK293, C-His)* Apolipoprotein E; APOE; Apo-E; APOE2	Human	HEK293
	Apolipoprotein E (APOE) plays a key role in lipoprotein-mediated lipid transport and is a core component in the production, transformation, and clearance of plasma lipoproteins. As an amphipathic molecule, APOE binds to various lipoprotein particles, including chylomicrons, chylomicron remnants, VLDL, and IDL, favoring HDL. Apolipoprotein E/APOE Protein, Human (R154S, R176C, HEK293, C-His) is the recombinant human-derived Apolipoprotein E/APOE protein, expressed by HEK293 , with C-6*His labeled tag and R154S, R176C, , , mutation. The total length of Apolipoprotein E/APOE Protein, Human (R154S, R176C, HEK293, C-His) is 299 a.a., with molecular weight of 33-42 kDa.

HY-P78239

	*Apolipoprotein E/APOE* Protein, Mouse (HEK293, Fc)** Apolipoprotein E; Apo-E; APOE; apolipo E	Mouse	HEK293
	Apolipoprotein E/APOE is crucial in lipid transport and participates in the production, transformation and clearance of plasma lipoproteins. It interacts with various particles, including chylomicrons and high-density lipoproteins, and binds to cellular receptors such as LDLR and VLDLR, promoting uptake. Apolipoprotein E/APOE Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Apolipoprotein E/APOE protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Apolipoprotein E/APOE Protein, Mouse (HEK293, Fc) is 293 a.a., with molecular weight of 62-66 kDa.

HY-P78542

	*Apolipoprotein E/APOE4 Protein, Human (C130R, HEK293, Fc)* Apolipoprotein E; Apo-E; APOE; apolipo E; APOE4	Human	HEK293
	Apolipoprotein E (APOE) plays a key role in lipoprotein-mediated lipid transport and is a core component in the production, transformation, and clearance of plasma lipoproteins. As an amphipathic molecule, APOE binds to various lipoprotein particles, including chylomicrons, chylomicron remnants, VLDL, and IDL, favoring HDL. Apolipoprotein E/APOE Protein, Human (C130R, HEK293, Fc) is the recombinant human-derived Apolipoprotein E/APOE protein, expressed by HEK293 , with N-hFc labeled tag and C130R, , , , mutation. The total length of Apolipoprotein E/APOE Protein, Human (C130R, HEK293, Fc) is 299 a.a., with molecular weight (glycosylation form) of 63-67 kDa.

HY-P78062

	*Apolipoprotein E/APOE3 Protein, Human (Biotinylated, HEK293, His)* Apolipoprotein E; Apo-E; APOE; apolipo E; APOE3	Human	HEK293
	Apolipoprotein E (APOE) plays a key role in lipoprotein-mediated lipid transport and is a core component in the production, transformation, and clearance of plasma lipoproteins. As an amphipathic molecule, APOE binds to various lipoprotein particles, including chylomicrons, chylomicron remnants, VLDL, and IDL, favoring HDL. Apolipoprotein E/APOE Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived Apolipoprotein E/APOE protein, expressed by HEK293 , with N-His labeled tag. The total length of Apolipoprotein E/APOE Protein, Human (Biotinylated, HEK293, His) is 299 a.a., with molecular weight of 35-40 kDa.

HY-P700273A

	*Apolipoprotein E/APOE3 Protein, Human (HEK293, C-His)* rHuApolipoprotein E, His; APOE; Apolipoprotein E; APOE3	Human	HEK293
	Apolipoprotein E (APOE) plays a pivotal role in lipoprotein-mediated lipid transport, acting as a core component in plasma lipoproteins' production, conversion, and clearance. As an amphipathic molecule, APOE associates with various lipoprotein particles, including chylomicrons, chylomicron remnants, VLDL, and IDL, favoring HDL. It engages with cellular receptors, such as LDLR, LRP1, LRP2, LRP8, and VLDLR, facilitating cellular uptake of APOE-containing lipoproteins. APOE's functions include mediating lipoprotein clearance, participating in biosynthesis, and uptake of VLDLs by peripheral tissues for triglyceride delivery, contributing to lipid homeostasis, reverse cholesterol transport, and playing diverse roles in the central nervous system, immune responses, and transcriptional regulation. Apolipoprotein E/APOE Protein, Human (HEK293, C-His) is the recombinant human-derived Apolipoprotein E/APOE protein, expressed by HEK293, with C-6*His labeled tag. The total length of Apolipoprotein E/APOE Protein, Human (HEK293, C-His) is 298 a.a., with molecular weight of ~36.36 kDa.

HY-P701051

	*Apolipoprotein E/APOE3 Protein, Human (HEK293, hFc)* Apolipoprotein E; Apo-E; APOE; apolipo E; APOE3	Human	HEK293
	Apolipoprotein E (APOE) plays a key role in lipoprotein-mediated lipid transport and is a core component in the production, transformation, and clearance of plasma lipoproteins. As an amphipathic molecule, APOE binds to various lipoprotein particles, including chylomicrons, chylomicron remnants, VLDL, and IDL, favoring HDL. Apolipoprotein E/APOE3 Protein, Human (HEK293, hFc) is the recombinant human-derived Apolipoprotein E/APOE3 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of Apolipoprotein E/APOE3 Protein, Human (HEK293, hFc) is 299 a.a., with molecular weight of 60-70 kDa.

HY-P700853

Apolipoprotein E/APOE4 Protein, Human (HEK293, His)

Apolipoprotein E; Apo-E; APOE; apolipo E; APOE4
Human HEK293

HY-P7532

	*Apolipoprotein E/APOE* Protein, Mouse (HEK293, His)** rMuApolipoprotein E, His; APOE; Apolipoprotein E	Mouse	HEK293
	Apolipoprotein E Protein, Mouse (HEK293, His) expresses in HEK293 with a His tag at the N-terminus. Apolipoprotein E regulates tight junction (TJs) function by regulating PKCη activity and phosphorylation of occludin on its Thr residues in an isoform-dependent manner. Apolipoprotein E also promotes cholesterol release.

HY-P7531

	*Apolipoprotein E/APOE3 Protein, Human (HEK293, His)* rHuApolipoprotein E, His; APOE; Apolipoprotein E; APOE3	Human	HEK293
	Apolipoprotein E/ApoE3 Protein, Human (HEK293, His) expresses in HEK293 with a His tag at the N-terminus. Apolipoprotein E/ApoE Protein, Human (HEK293, His) promotes cholesterol release in an isoform-dependent manner.

HY-P72083

	*Apolipoprotein E/APOE* Protein, Rabbit (His-SUMO)** APOEApolipoprotein E; Apo-E	Rabbit	E. coli
	Apolipoprotein E/APOE is essential for lipid transport between organs and is a key component of lipoproteins such as chylomicrons and high-density lipoprotein. It binds to cell receptors such as LDLR and VLDLR to promote lipoprotein uptake, and has heparin-binding activity to interact with cell surface proteoglycans. Apolipoprotein E/APOE Protein, Rabbit (His-SUMO) is the recombinant Rabbit-derived Apolipoprotein E/APOE protein, expressed by E. coli , with N-10*His, N-SUMO labeled tag. The total length of Apolipoprotein E/APOE Protein, Rabbit (His-SUMO) is 292 a.a., with molecular weight of ~53.6 kDa.

HY-P72084

	*Apolipoprotein E/APOE* Protein, Rabbit (His-B2M, Myc)** APOEApolipoprotein E; Apo-E	Rabbit	E. coli
	Apolipoprotein E/APOE is essential for lipid transport between organs and is a key component of lipoproteins such as chylomicrons and high-density lipoprotein. It binds to cell receptors such as LDLR and VLDLR to promote lipoprotein uptake, and has heparin-binding activity to interact with cell surface proteoglycans. Apolipoprotein E/APOE Protein, Rabbit (His-B2M, Myc) is the recombinant Rabbit-derived Apolipoprotein E/APOE protein, expressed by E. coli , with N-10*His, C-Myc, N-B2M labeled tag. The total length of Apolipoprotein E/APOE Protein, Rabbit (His-B2M, Myc) is 292 a.a., with molecular weight of ~55 kDa.

HY-P701096

	*Apolipoprotein E/APOE* Protein, Rat (His)** APOEApolipoprotein E; Apo-E	Rat	E. coli
	Apolipoprotein E/APOE is essential for lipid transport and is integral to the production, transformation and clearance of plasma lipoproteins. It interacts with various particles to favor HDL and binds to receptors such as LDLR and VLDLR to promote cellular uptake. Apolipoprotein E/APOE Protein, Rat (His) is the recombinant rat-derived Apolipoprotein E/APOE protein, expressed by E. coli , with N-6*His labeled tag. The total length of Apolipoprotein E/APOE Protein, Rat (His) is 294 a.a., with molecular weight of 39.8 kDa.


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Cat. No.	Product Name	Application	Reactivity

HY-P81771

ApoE Antibody (YA1516)

APOE; Apolipoprotein E; Apo-E
WB, IHC-P, ICC/IF, IP Human, Mouse

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