APP

By Targets:	5-HT Receptor (1) Adrenergic Receptor (1) Akt (2) Amino Acid Derivatives (2) Aminoacyl-tRNA Synthetase (2) Amyloid-β (23) Antibiotic (1) Apoptosis (7) Autophagy (3) Bacterial (2) BCRP (1) Beta-secretase (6) Btk (1) Calcium Channel (1) Caspase (2) Cholinesterase (ChE) (2) Deubiquitinase (1) Dihydroorotate Dehydrogenase (1) DNA/RNA Synthesis (1) Endogenous Metabolite (1) Fluorescent Dye (3) Histamine Receptor (1) Histone Methyltransferase (1) Huntingtin (1) IRE1 (1) JAK (1) Kinesin (1) MAP3K (1) MAPKAPK2 (MK2) (1) MEK (1) nAChR (2) NF-κB (2) Parasite (1) Phosphatase (4) PI3K (1) PI4K (1) RIP kinase (1) Small Interfering RNA (siRNA) (3) TMV (1) Tyrosinase (1) α-synuclein (1) γ-secretase (4)
By Research Areas:	Cancer (15) Cardiovascular Disease (3) Endocrinology (1) Infection (9) Inflammation/Immunology (11) Metabolic Disease (1) Neurological Disease (41)
Click Chemistry:	Alkynes (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-RS00863

APP Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
APP Human Pre-designed siRNA Set A contains three designed siRNAs for APP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

APP Human Pre-designed siRNA Set A APP Human Pre-designed siRNA Set A

HY-RS00864

App Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
App Mouse Pre-designed siRNA Set A contains three designed siRNAs for App gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

App Mouse Pre-designed siRNA Set A App Mouse Pre-designed siRNA Set A

HY-RS00865

App Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
App Rat Pre-designed siRNA Set A contains three designed siRNAs for App gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

App Rat Pre-designed siRNA Set A App Rat Pre-designed siRNA Set A

HY-P10180

β-Amyloid/A4 Protein Precusor (319-335) APP (319-335)	Amyloid-β	Neurological Disease
β-Amyloid/A4 Protein Precusor (319-335) (APP (319-335)) is a peptide fragment of β-Amyloid/A4 protein precursor (APP). β-Amyloid/A4 Protein Precusor (319-335) can recognize the heparinase-insensitive site that contains the neuritotropic activity of APP .

HY-103538

JLK-6	Amyloid-β	Neurological Disease
JLK-6 markedly reduce the production of amyloid β-peptide (Aβ) by amyloid-β Precursor protein (APP) expressing HEK293 cells by affecting the γ-secretase cleavage of APP, with no effect on the cleavage of the Notch receptor .

HY-114174

Fmoc-Ala-Glu-Asn-Lys-NH2	Amyloid-β	Neurological Disease
Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing .

HY-N12249

7-Deoxy-trans-dihydronarciclasine	Amyloid-β TMV	Infection Neurological Disease Inflammation/Immunology
7-Deoxy-trans-dihydronarciclasine, an alkaloid, is a tobacco mosaic virus (TMV) inhibitor (IC₅₀: 1.80 μM). 7-Deoxy-trans-dihydronarciclasine is an anti-neuroinflammatory agent. 7-Deoxy-trans-dihydronarciclasine decreases the Aβ and *APP* levels in the cerebral cortex of Tg2576 mice .

HY-P990078

Remternetug LY3372993	Amyloid-β	Neurological Disease
Remternetug is a human immunoglobulin G1-kappa, *anti-APP* (amyloid beta A4 precursor protein) Aβ42 N3pGlu** peptide monoclonal antibody. Remternetug recognizes a pyroglutamated form of Aβ that aggregates into amyloid plaques .

HY-50882

ELN318463	γ-secretase	Neurological Disease
ELN318463 is an amyloid precursor protein (APP) selective γ-secretase inhibitor. ELN318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC₅₀s of 12 nM and 656 nM for PS1 and PS2, respectively. ELN318463 is 51-fold more selective for PS1 .

HY-50882A

ELN318463 racemate	γ-secretase	Neurological Disease
ELN318463 racemate is the racemate of ELN318463. ELN318463 is an amyloid precursor protein (APP) selective γ-secretase inhibitor. ELN318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC₅₀s of 12nM and 656 nM for PS1and PS2, respectively. ELN318463 is 51-fold more selective for PS1 .

HY-18292

ARN2966

Amyloid-β Neurological Disease

ARN2966 is a potent post-transcriptional modulator of APP expression; reduces expression of APP with resultant lower production of Aβ.
HY-136499

DI-82

Others Cancer

DI-82 is a potent deoxycytidine kinase (dCK) inhibitor with an IC₅₀ ^app of 27.8 nM and K_i ^app of 9.2 nM. DI-82 has antitumor activity .

ARN2966	Amyloid-β	Neurological Disease
ARN2966 is a potent post-transcriptional modulator of APP expression; reduces expression of APP with resultant lower production of Aβ.

DI-82	Others	Cancer
DI-82 is a potent deoxycytidine kinase (dCK) inhibitor with an IC₅₀ ^app of 27.8 nM and K_i ^app of 9.2 nM. DI-82 has antitumor activity .

HY-P1894

β-Amyloid Protein Precursor 770 (135-155)	Amyloid-β	Neurological Disease
β-Amyloid Protein Precursor 770 (135-155) is a peptide of amyloid precursor protein isoform (APP 770). APP 770 produces Aβ40/42 .

HY-50759

Ispinesib

5 Publications Verification

SB-715992
Kinesin Apoptosis Cancer

Ispinesib is a specific inhibitor of kinesin spindle protein (KSP), with a K_{i app} of 1.7 nM.

Ispinesib 5 Publications Verification SB-715992	Kinesin Apoptosis	Cancer
Ispinesib is a specific inhibitor of kinesin spindle protein (KSP), with a K_{i app} of 1.7 nM.

HY-124832

δ-Secretase inhibitor 11	Caspase Amyloid-β	Neurological Disease
δ-Secretase inhibitor 11 (compound 11) is an orally active, potent, BBB-penetrated, non-toxic, selective and specific δ-secretase inhibitor, with an IC₅₀ of 0.7 μM. δ-Secretase inhibitor 11 interacts with both the active site and allosteric site of δ-secretase. δ-Secretase inhibitor 11 attenuates tau and APP (amyloid precursor protein) cleavage. δ-Secretase inhibitor 11 ameliorates synaptic dysfunction and cognitive impairments in tau P301S and 5XFAD transgenic mouse models. δ-Secretase inhibitor 11 can be used for Alzheimer's disease research .

HY-12856

GSK503

5+ Cited Publications

Histone Methyltransferase Cancer

GSK503 is a potent and specific inhibitor of EZH2 methyltransferase with K_i ^app values of 3 to 27 nM.
HY-129096

IDT307

Fluorescent Dye Others

IDT307, an analog of the organic cation MPP+, is a specific fluorescent substrate for DAT (fluorescent substrate APP+) .

GSK503 5+ Cited Publications	Histone Methyltransferase	Cancer
GSK503 is a potent and specific inhibitor of EZH2 methyltransferase with K_i ^app values of 3 to 27 nM.

IDT307	Fluorescent Dye	Others
IDT307, an analog of the organic cation MPP+, is a specific fluorescent substrate for DAT (fluorescent substrate APP+) .

HY-139973

OAB-14	Amyloid-β	Neurological Disease
OAB-14, is a Bexarotene (HY-14171) derivative, improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice. OAB-14 effectively ameliorates the dysfunction of the endosomal-autophagic-lysosomal pathway in APP/PS1 transgenic mice .

HY-161110

Aβ42-IN-5	Amyloid-β	Neurological Disease
Aβ42-IN-5 (Compound 0152) is an oral active amyloid precursor protein (APP) degrader that can reduce Aβ42 in Alzheimer's disease iPSC neurons. Aβ42-IN-5 can bind CAPRIN1 and APP and enhance the protein-protein interaction .

HY-147672

IleRS-IN-1

Aminoacyl-tRNA Synthetase Infection

IleRS-IN-1 (compound 11) is a potent and selective isoleucyl-tRNA synthetase (IleRS) inhibitor, with a K_i,app of 88 nM .
HY-P1729

M-2420

Fluorescent Dye Neurological Disease

M-2420 is a fluorogenic substrate containing β-secretase site of the Swedish mutation of amyloid precursor protein (APP) .

IleRS-IN-1	Aminoacyl-tRNA Synthetase	Infection
IleRS-IN-1 (compound 11) is a potent and selective isoleucyl-tRNA synthetase (IleRS) inhibitor, with a *K_i,app* of 88 nM .

M-2420	Fluorescent Dye	Neurological Disease
M-2420 is a fluorogenic substrate containing β-secretase site of the Swedish mutation of amyloid precursor protein (APP) .

HY-P99185

Bapineuzumab	Amyloid-β	Neurological Disease
Bapineuzumab is an *anti-β-amyloid protein (APP) monoclonal antibody*. Bapineuzumab can be used for the research of Alzheimer’s disease (AD) .

HY-147674

Isoleucyl tRNA synthetase-IN-2	Aminoacyl-tRNA Synthetase	Infection
Isoleucyl tRNA synthetase-IN-2 (compound 36a) is a potent and selective isoleucyl-tRNA synthetase (IleRS) inhibitor, with a *K_i,app* of 114 nM .

HY-128464

LL320

Others Metabolic Disease

LL320 is a selective NNMT inhibitor with a K_i,app of 6.8 nM. LL320 exhibits interactions with RNMT, DPH₅, and SAHH .
HY-108643

CMPD1

MAPKAPK2 (MK2) Cancer

CMPD1 is a selective and non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor with apparent K_i (K_i ^app) of 330 nM .
HY-15294

CZC24832

PI3K Inflammation/Immunology Cancer

CZC24832 is a highly selective and potent PI3Kγ inhibitor (IC₅₀=27 nM) with apparent dissociation constants (K_d ^app) of 19 nM.
HY-161109

Aβ42-IN-4

Amyloid-β Neurological Disease

Aβ42-IN-4 (compound 0043) degrades amyloid precursor protein (APP) and reduces Aβ42 production .

LL320	Others	Metabolic Disease
LL320 is a selective NNMT inhibitor with a *K_i,app* of 6.8 nM. LL320 exhibits interactions with RNMT, DPH₅, and SAHH .

CMPD1	MAPKAPK2 (MK2)	Cancer
CMPD1 is a selective and non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor with apparent K_i (K_i ^app) of 330 nM .

CZC24832	PI3K	Inflammation/Immunology Cancer
CZC24832 is a highly selective and potent PI3Kγ inhibitor (IC₅₀=27 nM) with apparent dissociation constants (K_d ^app) of 19 nM.

Aβ42-IN-4	Amyloid-β	Neurological Disease
Aβ42-IN-4 (compound 0043) degrades amyloid precursor protein (APP) and reduces Aβ42 production .

HY-106005

MMV390048 2 Publications Verification	Parasite PI4K	Infection
MMV390048 is a representative of a new chemical class of Plasmodium PI4K inhibitor (K_d ^app=0.3 µM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns. MMV390048 is an antimalarial agent .

HY-50883

BMS 299897	γ-secretase	Neurological Disease
BMS 299897 is a sulfonamide γ-secretase inhibitor with an IC₅₀ of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor protein (APP).

HY-P4553

H-Met-Pro-OH	Amino Acid Derivatives	Others
H-Met-Pro-OH is a dipeptide containing methionine and proline. H-Met-Pro-OH is a substrate for aminopeptidase P (APP) and skin fibroblast prolidase .

HY-14537

Latrepirdine dihydrochloride Dimebolin dihydrochloride	Amyloid-β Histamine Receptor Adrenergic Receptor 5-HT Receptor Autophagy	Neurological Disease Endocrinology
Latrepirdine dihydrochloride is a neuroactive compound with antagonist activity at histaminergic, α-adrenergic, and serotonergic receptors. Latrepirdine stimulates amyloid precursor protein (APP) catabolism and amyloid-β (Aβ) secretion.

HY-12989

LDN-91946	Deubiquitinase	Neurological Disease Cancer
LDN-91946 is a potent, selective and uncompetitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor with a K_{i app} of 2.8 μM .

HY-149396

FXIIa-IN-1

Others Cardiovascular Disease

XIIa-IN-1-IN-3 (Compound 22) is a Factor XIIa inhibitor (K_i ^app: 97.8 nM). XIIa-IN-1-IN-3 can be used for research of thrombosis .
HY-149397

FXIIa-IN-2

Others Cardiovascular Disease

FXIIa-IN-1-IN-2 (Compound 21) is a Factor XIIa inhibitor (K_i ^app: 62.2 nM). FXIIa-IN-1-IN-2 can be used for research of thrombosis .

FXIIa-IN-1	Others	Cardiovascular Disease
XIIa-IN-1-IN-3 (Compound 22) is a Factor XIIa inhibitor (K_i ^app: 97.8 nM). XIIa-IN-1-IN-3 can be used for research of thrombosis .

FXIIa-IN-2	Others	Cardiovascular Disease
FXIIa-IN-1-IN-2 (Compound 21) is a Factor XIIa inhibitor (K_i ^app: 62.2 nM). FXIIa-IN-1-IN-2 can be used for research of thrombosis .

HY-16009B

Buntanetap L-Tartrate (+)-Phenserine L-Tartrate; ANVS401 L-Tartrate	Amyloid-β	Cancer
Buntanetap (L-Tartrate) is an orally administered small molecule inhibitor of several neurotoxic proteins. Buntanetap reduces amyloid precursor protein (APP) production by blocking its mRNA translation .

HY-128585

GNE684	RIP kinase	Inflammation/Immunology Cancer
GNE684 is a potent inhibitor of potent receptor interacting protein 1 (RIP1), with mean K_i ^app values of 21 nM, 189 nM and 691 nM for human mouse and rat RIP1, respectively .

HY-144739

BACE1-IN-8

Beta-secretase Neurological Disease

BACE1-IN-8 (compound 70b) is a potent BACE1 (β-site APP cleaving enzyme 1) inhibitor, with an IC₅₀ of 3.9 µM .
HY-144741

BACE1-IN-9

Beta-secretase Neurological Disease

BACE1-IN-9 (compound 82b) is a potent BACE1 (β-site APP cleaving enzyme 1) inhibitor, with an IC₅₀ of 1.2 µM .

BACE1-IN-8	Beta-secretase	Neurological Disease
BACE1-IN-8 (compound 70b) is a potent BACE1 (β-site APP cleaving enzyme 1) inhibitor, with an IC₅₀ of 3.9 µM .

BACE1-IN-9	Beta-secretase	Neurological Disease
BACE1-IN-9 (compound 82b) is a potent BACE1 (β-site APP cleaving enzyme 1) inhibitor, with an IC₅₀ of 1.2 µM .

HY-107164

Thiomarinol A 4-Hydroxythiomarinol C	Antibiotic Bacterial	Infection
Thiomarinol A (4-Hydroxythiomarinol C) is a potent antibiotic. Thiomarinol A is a hybrid of dithiolopyrrolone and marinolic acid. Thiomarinol A shows antimicrobial activity. Thiomarinol A inhibits MRSA IleRS in a dose-dependent with a K_i ^app value of 19 nM .

HY-105940

IQB-782	Amino Acid Derivatives	Cardiovascular Disease
IQB-782 is a cysteine derivative. IQB-782 has inhibition for thrombin activatable fibrinolysis inhibitor (TAFI), with an *K_i*(app) of 0.14 μM. IQB-782 shows a potent mucolytic-expectorant activity .

HY-P4885

Glp-amyloid-β (3-40) peptide (human) AβpE3-40	Amyloid-β	Neurological Disease
Glp-Amyloid-β (3-40) Peptide (human) (AβpE3-40) is a minor amounts of pyroglutamate-modified Aβ isolated from from 24-month-old Amyloid precursor protein (APP) transgenic Mice .

HY-153986

AEP-IN-2	Others	Neurological Disease
AEP-IN-2 is an asparagine endopeptidase (AEP) inhibitor via block AEP cleavage of APP and Tau. AEP-IN-2 has oral activity and decreases Aβ40 and Aβ42 and p-Tau levels .

HY-124322

NB-360	Beta-secretase	Neurological Disease Inflammation/Immunology
NB-360 is a potent, brain penetrable, and orally bioavailable dual BACE1/BACE2 inhibitor (IC₅₀: mouse and human BACE1=5 nM; BACE2=6 nM). NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in amyloid precursor protein(APP) transgenic mice. NB-360 can completely block the progression of Aβ deposition in the brains of APP transgenic mice. NB-360 shows excellent selectivity over the related aspartyl proteases pepsin, cathepsin D and cathepsin E .

HY-108966

Kushenol C	Beta-secretase	Inflammation/Immunology
Kushenol C, isolated from the roots of Sophora flavescens, shows anti-Inflammatory and anti-oxidative stress activities. Kushenol C inhibits *BACE1 (β-site APP* cleaving enzyme 1) with an IC₅₀** of 5.45 µM .

HY-135618

DHODH-IN-3	Dihydroorotate Dehydrogenase DNA/RNA Synthesis	Infection
DHODH-IN-3 (compound 3) is a potent inhibitor of Human Dihydroorotate Dehydrogenases (HsDHODH) with an IC₅₀ value of 261 nM. DHODH-IN-3 binds to the the ubiquinone binding cavities in DHODH with a K_i ^app of 32 nM. DHODH-IN-3 has the potential for malaria treatment .

HY-P10163

α-Secretase Substrate II, Fluorogenic	Fluorescent Dye	Others
α-Secretase Substrate II, Fluorogenic is an internally quenched fluorogenic peptide substrate for α-Secretase that contains the α-secretase cleavage site of β-Amyloid precursor protein (APP) .Ex/Em = 340/490 nm

HY-P9999

Trontinemab RG6102; RO-7126209	Amyloid-β	Neurological Disease
Trontinemab is a bispecific and humanizedized IgG1-κ antibody, targeting to amyloid beta A4 precursor protein (APP) and transferrin receptor, p90, CD71 (TFRC). Trontinemab can be used for research on Alzheimer disease (AD) .

HY-16009

Buntanetap (+)-Phenserine; ANVS401	Cholinesterase (ChE) Amyloid-β α-synuclein Huntingtin	Neurological Disease Inflammation/Immunology
Buntanetap ((+)-Phenserine) is a multiple neurotoxic protein translation inhibitor with oral activity, including amyloid precursor protein (APP), α-synuclein (αSYN) and huntingtin protein (HTT). Buntanetap has anti-inflammatory effects and can be used in the study of Alzheimer's disease and Parkinson's disease .

HY-P2551

Biotin-β-Amyloid (17-40)	Amyloid-β	Neurological Disease
Biotin-β-Amyloid (17-40) is a N-terminal-labelled biotinylated amyloid-ß-(1-40) peptide. β-Amyloid (17-40) is a 24-residue fragment of the Aβ protein via post-translational processing of amyloid precursor protein (APP) .

HY-103374

Phenserine (-)-Eseroline phenylcarbamate; (-)-Phenserine	Cholinesterase (ChE) Amyloid-β	Neurological Disease
Phenserine ((-)-Eseroline phenylcarbamate) is a derivative of Physostigmine and is a potent, noncompetitive, long-acting and selective AChE inhibitor. Phenserine reduces β-amyloid precursor protein (APP) and β-amyloid peptide (Aβ) formation. Phenserine improves cognitive performance and attenuates the progression of Alzheimer's disease .

Cat. No.	Product Name	Type

HY-129096

IDT307

Chromogenic Substrates

IDT307, an analog of the organic cation MPP+, is a specific fluorescent substrate for DAT (fluorescent substrate APP+) .

Cat. No.	Product Name	Target	Research Area

HY-114174

Fmoc-Ala-Glu-Asn-Lys-NH2	Amyloid-β	Neurological Disease
Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing .

HY-P10180

β-Amyloid/A4 Protein Precusor (319-335) APP (319-335)	Amyloid-β	Neurological Disease
β-Amyloid/A4 Protein Precusor (319-335) (APP (319-335)) is a peptide fragment of β-Amyloid/A4 protein precursor (APP). β-Amyloid/A4 Protein Precusor (319-335) can recognize the heparinase-insensitive site that contains the neuritotropic activity of APP .

HY-P1894

β-Amyloid Protein Precursor 770 (135-155)	Amyloid-β	Neurological Disease
β-Amyloid Protein Precursor 770 (135-155) is a peptide of amyloid precursor protein isoform (APP 770). APP 770 produces Aβ40/42 .

HY-P1729

M-2420

Fluorescent Dye Neurological Disease

M-2420 is a fluorogenic substrate containing β-secretase site of the Swedish mutation of amyloid precursor protein (APP) .

HY-P4553

H-Met-Pro-OH	Amino Acid Derivatives	Others
H-Met-Pro-OH is a dipeptide containing methionine and proline. H-Met-Pro-OH is a substrate for aminopeptidase P (APP) and skin fibroblast prolidase .

HY-P4926

Mca-SEVKMDAEFRK(Dnp)RR-NH2	Peptides	Neurological Disease
Mca-SEVKMDAEFRK(Dnp)RR-NH2, containing the wild-type amyloid precursor protein (APP) beta-secretase cleavage site, is the substrate of thimet oligopeptidase (TOP). It is used for Alzheimer's disease research .

HY-P4885

Glp-amyloid-β (3-40) peptide (human) AβpE3-40	Amyloid-β	Neurological Disease
Glp-Amyloid-β (3-40) Peptide (human) (AβpE3-40) is a minor amounts of pyroglutamate-modified Aβ isolated from from 24-month-old Amyloid precursor protein (APP) transgenic Mice .

HY-P5274

BACE1 (485-501)	Peptides	Others
BACE1 (485-501) is the carboxyl terminal of BACE1 (Beta-site APP cleaving enzyme 1). BACE1 (485-501) can be used as antigen to produce anti-BACE1-C antibody .

HY-P10163

α-Secretase Substrate II, Fluorogenic	Fluorescent Dye	Others
α-Secretase Substrate II, Fluorogenic is an internally quenched fluorogenic peptide substrate for α-Secretase that contains the α-secretase cleavage site of β-Amyloid precursor protein (APP) .Ex/Em = 340/490 nm

HY-P2551

Biotin-β-Amyloid (17-40)	Amyloid-β	Neurological Disease
Biotin-β-Amyloid (17-40) is a N-terminal-labelled biotinylated amyloid-ß-(1-40) peptide. β-Amyloid (17-40) is a 24-residue fragment of the Aβ protein via post-translational processing of amyloid precursor protein (APP) .

HY-136733

Ac-DNLD-CHO Ac-Asp-Asn-Leu-Asp-CHO	Caspase	Infection Neurological Disease
Ac-DNLD-CHO (Ac-Asp-Asn-Leu-Asp-CHO) is a Caspase-3/7 inhibitor (IC₅₀: 9.89, 245 nM respectively; K_i ^app: 0.68, 55.7 nM respectively). Ac-DNLD-CHO can be used for research of caspase-mediated apoptosis diseases, such as neurodegenerative disorders and viral infection diseases .

HY-P1378

β-Amyloid (1-43)(human)	Amyloid-β	Neurological Disease
β-Amyloid (1-43)(human) is more prone to aggregation and has higher toxic properties than the long-known Aβ1-42. β-Amyloid (1-43)(human) shows a correlation with both sAPPα and sAPPβ. β-Amyloid (1-43)(human) could be considered an added Alzheimer's disease (AD) biomarker together with the others already in use .

HY-P1378A

β-Amyloid (1-43)(human) TFA	Amyloid-β	Neurological Disease
β-Amyloid (1-43)(human) TFA is more prone to aggregation and has higher toxic properties than the long-known Aβ1-42. β-Amyloid (1-43)(human) TFA shows a correlation with both sAPPα and sAPPβ. β-Amyloid (1-43)(human) TFA could be considered an added Alzheimer's disease (AD) biomarker together with the others already in use .

HY-P3779

Amyloid 17-42 Aβ(17-42)	Apoptosis	Neurological Disease
Amyloid 17-42 (Aβ(17-42)) is a major constituent of diffuse plaques in Alzheimer's disease and cerebellar pre-amyloid in Down's syndrome, derived by alpha- and gamma-secretase cleavage of the amyloid precursor protein (APP). Amyloid 17-42 can induce neuronal apoptosis via a Fas-like/caspase-8 activation pathway .

HY-P1383

Rac1 Inhibitor F56, control peptide	Peptides	Others
Rac1 Inhibitor F56, control peptide is a peptide containing residues 45-60 of Rac1. Rac1 Inhibitor F56, control peptide contains a Trp ⁵⁶ to Phe ⁵⁶ mutation. Rac1 Inhibitor F56, control peptide has no effect on Rac1 interaction with its guanine nucleotide exchange factors (GEFs) .

HY-P4919

Mca-SEVNLDAEFK(Dnp)	Beta-secretase	Others
Mca-SEVNLDAEFK(Dnp) is a Beta-secretase 1 (BACE-1) peptide FRET substrate, containing the 'Swedish' Lys-Met/Asn-Leu mutation of the amyloid precursor protein (APP) β-secretase cleavage site. Cleavage at -Leu-Asp- of Mca-SEVNLDAEFK(Dnp) liberates the highly fluorescent 7-methoxycoumarin (Mca) fragment from the proximity quenching effect of the 2,4-dinitrophenyl (Dnp) internal quencher resulting in a large and easily detectable increase in fluorescence intensity.

HY-P5331

[Asn23]-beta-Amyloid (1-42), iowa mutation	Peptides	Others
[Asn23]-beta-Amyloid (1-42), iowa mutation is a biological active peptide. (Several mutations in the beta amyloid precursor gene cause autosomal dominant Alzheimer's Disease in a number of kindreds. The Iowa mutation, where Asp 23 is replaced with Asn, is associated with severe cerebral amyloid beta-protein angiopathy (CAA). The affected individuals share a missense mutation in APP at position 694. The mutated beta-amyloid peptide aggregates more rapidly and forms toxic fibrils.)

HY-P5365

[Asn23] β-Amyloid (1-40), Iowa mutation	Peptides	Others
[Asn23] β-Amyloid (1-40), Iowa mutation is a biological active peptide. (Several mutations in the beta amyloid precursor gene cause autosomal dominant Alzheimer's Disease in a number of kindreds. The Iowa mutation, where Asp 23 is replaced with Asn, is associated with severe cerebral amyloid beta-protein angiopathy (CAA). The affected individuals share a missense mutation in APP at position 694. The mutated beta-amyloid peptide aggregates more rapidly and forms toxic fibrils.)

Cat. No.	Product Name	Target	Research Area

HY-P99185

Bapineuzumab	Amyloid-β	Neurological Disease
Bapineuzumab is an *anti-β-amyloid protein (APP) monoclonal antibody*. Bapineuzumab can be used for the research of Alzheimer’s disease (AD) .

HY-P9999

Trontinemab RG6102; RO-7126209	Amyloid-β	Neurological Disease
Trontinemab is a bispecific and humanizedized IgG1-κ antibody, targeting to amyloid beta A4 precursor protein (APP) and transferrin receptor, p90, CD71 (TFRC). Trontinemab can be used for research on Alzheimer disease (AD) .

HY-P990078

Remternetug LY3372993	Amyloid-β	Neurological Disease
Remternetug is a human immunoglobulin G1-kappa, *anti-APP* (amyloid beta A4 precursor protein) Aβ42 N3pGlu** peptide monoclonal antibody. Remternetug recognizes a pyroglutamated form of Aβ that aggregates into amyloid plaques .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0192

Arbutin 1 Publications Verification β-Arbutin	Bergenia purpurascens (Hook. f. et Thoms.) Engl. Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Phenols Plants Saxifragaceae Endogenous metabolite Disease Research Fields Cancer	Tyrosinase Endogenous Metabolite
Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase, with K_i ^app values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents . Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties .

HY-N12249

7-Deoxy-trans-dihydronarciclasine	Hosta plantaginea (Lam.) Aschers. Structural Classification Alkaloids Source classification Quinoline Alkaloids Plants Asparagaceae Juss.	Amyloid-β TMV
7-Deoxy-trans-dihydronarciclasine, an alkaloid, is a tobacco mosaic virus (TMV) inhibitor (IC₅₀: 1.80 μM). 7-Deoxy-trans-dihydronarciclasine is an anti-neuroinflammatory agent. 7-Deoxy-trans-dihydronarciclasine decreases the Aβ and *APP* levels in the cerebral cortex of Tg2576 mice .

HY-107164

Thiomarinol A 4-Hydroxythiomarinol C	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Other Antibiotics	Antibiotic Bacterial
Thiomarinol A (4-Hydroxythiomarinol C) is a potent antibiotic. Thiomarinol A is a hybrid of dithiolopyrrolone and marinolic acid. Thiomarinol A shows antimicrobial activity. Thiomarinol A inhibits MRSA IleRS in a dose-dependent with a K_i ^app value of 19 nM .

HY-108966

Kushenol C	Flavonols Flavonoids Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Plants Sophora flavescens Aiton Disease Research Fields Inflammation/Immunology	Beta-secretase
Kushenol C, isolated from the roots of Sophora flavescens, shows anti-Inflammatory and anti-oxidative stress activities. Kushenol C inhibits *BACE1 (β-site APP* cleaving enzyme 1) with an IC₅₀** of 5.45 µM .

Species:	Human (7)
Tag:	His (5) SUMO (1) GST (2) Fc (2)
Source:	HEK293 (2) E. coli (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P72834

	APP/Protease Nexin-II Protein, Human (HEK293, Fc) Amyloid-beta precursor protein; APP; CVAP; PN-II; PreA4; A4; AD1	Human	HEK293
	There is no specific Pubmed ID mentioned in the paragraph. APP/Protease Nexin-II Protein, Human (HEK293, Fc) is the recombinant human-derived APP/Protease Nexin-II protein, expressed by HEK293 , with C-hFc labeled tag. The total length of APP/Protease Nexin-II Protein, Human (HEK293, Fc) is 652 a.a., with molecular weight of 150-160 kDa.

HY-P70830

	Cathepsin B Protein, Human (His) Cathepsin B; APP Secretase; APPS; Cathepsin B1; CTSB; CPSB	Human	E. coli
	Cathepsin B Protein, a thiol protease, is crucial for intracellular protein degradation, cleaving matrix extracellular phosphoglycoprotein MEPE. It's implicated in solubilizing cross-linked TG/thyroglobulin in the thyroid follicle lumen. Associated with tumor invasion and metastasis, Cathepsin B signifies potential relevance in cancer-related pathways. Cathepsin B Protein, Human (His) is the recombinant human-derived Cathepsin B protein, expressed by E. coli , with C-6*His labeled tag. The total length of Cathepsin B Protein, Human (His) is 322 a.a., with molecular weight of 34 & 38-50 kDa, respectively.

HY-P75511

	*Amyloid Precursor/Beta-APP40 Protein, Human (His-GST)* Amyloid-beta precursor protein; APP; Protease Nexin II; PreA4	Human	E. coli
	There is no specific Pubmed ID mentioned in the paragraph. Amyloid Precursor/Beta-APP40 Protein, Human (His-GST) is the recombinant human-derived Amyloid Precursor/Beta-APP40 protein, expressed by E. coli , with N-His, N-GST labeled tag. The total length of Amyloid Precursor/Beta-APP40 Protein, Human (His-GST) is 40 a.a., with molecular weight of ~33 kDa.

HY-P71435

	XPNPEP3 Protein, Human (His) Probable Xaa-Pro Aminopeptidase 3; X-Pro Aminopeptidase 3; Aminopeptidase P3; APP3; XPNPEP3	Human	E. coli
	The XPNPEP3 protein catalyzes the removal of prolyl residues from N-terminal peptides (such as Leu-Pro-Ala) and has low activity towards Ala or Ser at the P1 site. XPNPEP3 Protein, Human (His) is the recombinant human-derived XPNPEP3 protein, expressed by E. coli , with N-6His, C-6His labeled tag. The total length of XPNPEP3 Protein, Human (His) is 507 a.a., with molecular weight of ~65.0 kDa.

HY-P700260

	Aminopeptidase P1 Protein, Human (His-SUMO) Aminoacylproline aminopeptidase; aminopeptidase P, cytosolic; APP1; Cytosolic aminopeptidase P; RP11 451M19.1; sAmp; Soluble aminopeptidase P; soluble; X Pro aminopeptidase 1; X prolyl aminopeptidase (aminopeptidase P) 1; X prolyl aminopeptidase (Aminopeptidase P) 1 soluble; X prolyl aminopeptidase 1; X prolyl aminopeptidase 1 soluble; X-Pro aminopeptidase 1; X-prolyl aminopeptidase 1; Xaa Pro aminopeptidase 1; Xaa-Pro aminopeptidase 1; XPNPEP 1; XPNPEP; xpnpep1; XPNPEPL; XPNPEPL1; XPP1_HUMAN	Human	E. coli
	Aminopeptidase P1 Protein, a metalloaminopeptidase, crucially catalyzes the removal of penultimate prolyl residues from peptide N-termini, including substrates like Arg-Pro-Pro. This activity significantly contributes to specific peptide degradation, exemplified in bradykinin processing. Aminopeptidase P1's selective prolyl cleavage underscores its importance in modulating peptide structures and functions within biological systems. Aminopeptidase P1 Protein, Human (His-SUMO) is the recombinant human-derived Aminopeptidase P1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of Aminopeptidase P1 Protein, Human (His-SUMO) is 622 a.a., with molecular weight of ~85.8 kDa.

HY-P76168

	*Amyloid Precursor/Beta-APP42 Protein, Human (His-GST)* Amyloid-beta precursor protein; ABPP; PN-II; A4; AD1	Human	E. coli
	There is no specific Pubmed ID mentioned in the paragraph. Amyloid Precursor/Beta-APP42 Protein, Human (His-GST) is the recombinant human-derived Amyloid Precursor/Beta-APP42 protein, expressed by E. coli , with N-His, N-GST labeled tag. The total length of Amyloid Precursor/Beta-APP42 Protein, Human (His-GST) is 42 a.a., with molecular weight of ~27-31 KDa.

HY-P7501

	Amyloid Precursor Protein, Human (HEK293, Fc) rHuAmyloid Precursor, C-Fc; Amyloid-Precursor	Human	HEK293
	Amyloid Precursor Protein, Human (HEK293, Fc) is an Amyloid Precursor (APP) protein with C-Fc. Amyloid Precursor Protein can be used for the study of brain development, learning and memory, synaptic plasticity, and neurodegeneration.

Cat. No.	Product Name	Chemical Structure

HY-126242S

Tyk2-IN-7

Tyk2-IN-7 is a TYK2 JH2 inhibitor, binds to TYK2 JH2 domain with IC50 and Ki.app of 0.00053 μM and 0.00007 μM, respectively. Tyk2-IN-7 provides a highly selective alternative to conventional TYK2 orthosteric inhibitors, inhibits TYK2/JAK1/JAK2 kinase domain. Tyk2-IN-7 provides robust inhibition in a mouse IL-12-induced IFNγ pharmacodynamic model as well as efficacy in an IL-23 and IL-12-dependent mouse colitis model[1].

Cat. No.	Product Name	Application	Reactivity

HY-P82823

Phospho-Amyloid Precursor Protein (Thr743) Antibody (YA2568) APP; A4; AD1; Amyloid beta A4 protein; ABPP; APPI; APP; Alzheimer disease amyloid protein; Cerebral vascular amyloid peptide; CVAP; PreA4; Protease nexin-II; PN-II	WB, ICC/IF, IP	Human, Rat

HY-P81385

Amyloid Precursor Protein Antibody (YA1130) APP; A4; AD1; Amyloid beta A4 protein; ABPP; APPI; APP; Alzheimer disease amyloid protein; Cerebral vascular amyloid peptide; CVAP; PreA4; Protease nexin-II; PN-II	IHC-P	Human

HY-P82169

BACE1 Antibody (YA1914) BACE1; BACE; KIAA1149; Beta-secretase 1; Aspartyl protease 2; ASP2; Asp 2; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; Memapsin-2; Membrane-associated aspartic protease 2	WB, IP	Human, Mouse, Rat

Cat. No.	Product Name		Classification

HY-135699

TD52 1 Publications Verification		Alkynes
TD52, an Erlotinib (HY-50896) derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via regulating the CIP2A/PP2A/p-Akt signalling pathway. TD52 indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. TD52 has less p-EGFR inhibition and has potent anti-cancer activity . TD52 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-135699A

TD52 dihydrochloride 1 Publications Verification		Alkynes
TD52 dihydrochloride, an Erlotinib (HY-50896) derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 dihydrochloride mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via regulating the CIP2A/PP2A/p-Akt signalling pathway. TD52 dihydrochloride indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. TD52 dihydrochloride has less p-EGFR inhibition and has potent anti-cancer activity . TD52 (dihydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.


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