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ASK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (9) EGFR (2) MAP3K (10) p38 MAPK (3) PKC (1) ROCK (1)
By Research Areas:	Cancer (12) Inflammation/Immunology (6) Neurological Disease (1)

16

Inhibitors & Agonists

1

Peptides

2

Natural
Products

1

Recombinant Proteins

4

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

ASK1-IN-2	MAP3K Apoptosis	Inflammation/Immunology
ASK1-IN-2 is a potent and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC₅₀ of 32.8 nM. ASK1-IN-2 can be used for the research of ulcerative colitis .

ASK1-IN-1	p38 MAPK	Inflammation/Immunology
ASK1-IN-1 is a CNS-penetrant *ASK1* (apoptosis signal-regulating kinase 1) inhibitor, with good potency (cell IC₅₀=138 nM; Biochemical IC₅₀=21 nM) .

ASK1-IN-3	MAP3K Apoptosis	Inflammation/Immunology Cancer
ASK1-IN-3 is a potent and selective *ASK1* kinase inhibitor with IC₅₀ of 33.8 nM, as well as inhibits several cell cycle regulating kinases. ASK1-IN-3 has strong HepG2 cancer cells apoptosis induction and potent cell cycle arrest activities .

HY-153761

ASK1-IN-4

MAP3K Apoptosis Inflammation/Immunology Cancer

ASK1-IN-4 (Compound 17) is an ASK1 inhibitor (IC₅₀=0.2 μM). ASK1-IN-4 interacts with ATP-binding site of ASK1 .

ASK1-IN-5	MAP3K Apoptosis	Neurological Disease Inflammation/Immunology
ASK1-IN-5 (S-99) is an inhibitor of apoptosis signal-regulated kinase 1 (ASK1) and is useful in the study of autoimmune and neurodegenerative diseases .

limertinib ASK120067	EGFR	Cancer
limertinib (ASK120067) is a potent and orally active inhibitor of EGFR ^T790M (IC₅₀:0.3 nM) with selectivity over EGFR ^WT (IC₅₀:6.0 nM). limertinib is a third-generation EGFR-TKI for the research of non-small cell lung cancer (NSCLC) .

limertinib diTFA ASK120067 diTFA	EGFR	Cancer
limertinib (ASK120067) diTFA is a potent and orally active inhibitor of EGFR ^T790M (IC₅₀: 0.3 nM) with selectivity over EGFR ^WT (IC₅₀: 6.0 nM). limertinib diTFA is a third-generation EGFR-TKI for the research of non-small cell lung cancer (NSCLC) .

*TC ASK* 10**	MAP3K Apoptosis	Cancer
TC ASK 10 (Compound 10) is a potent, selective and orally active apoptosis signal-regulating kinase 1 (ASK1) inhibitor with an IC₅₀ of 14 nM. The inhibitory activities of TC ASK 10 towards other representative panel of kinases are less than 50%, except for ASK2 (IC₅₀ of 0.51 μM) .

DDO3711	MAP3K	Cancer
DDO3711, a PP5-recruiting phosphatase recruitment chimeras (PHORCs), is formed by connecting a small molecular apoptosis signal-regulated kinase 1 (ASK1) inhibitor to a PP5 activator through a chemical linker. DDO3711 specifically inhibits ASK1 (IC₅₀ =164.1 nM) not ASK2 (IC₅₀>20 μM). DDO3711 significantly dephosphorylates p-ASK1 ^T838 by recruiting PP5 and shows the ASK1-dependent antiproliferative activity. DDO3711 has anti-cancer activity and has the potential for abnormally phosphorylated oncoproteins research .

MSC 2032964A	p38 MAPK	Inflammation/Immunology
MSC 2032964A is an orally active, selective inhibitor for apoptosis signal-regulating kinase 1(ASK1) with IC₅₀ of 96 nM. MSC 2032964A preserves the visual responses in EAE mice model and exhibits potency in ameliorating the neuroinflammation .

HY-19566

NQDI-1

5+ Cited Publications

MAP3K Apoptosis Cancer

NQDI-1 inhibits apoptosis signal-regulating kinase 1 (ASK1) with a K_i of 500 nM and an IC₅₀ of 3 μM.

GS-444217 3 Publications Verification	MAP3K Apoptosis	Cancer
GS-444217 is a potent, orally available and selective ATP-competitive inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC₅₀ of 2.87 nM .

HY-161283

JT21-25

MAP3K Others

JT21-25 (compound 9h) is a potent and selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with IC₅₀ of 5.1 nM .

Selonsertib Maximum Cited Publications 13 Publications Verification GS-4997	MAP3K Apoptosis	Cancer
Selonsertib (GS-4997), an orally bioavailable, selective apoptosis signal-regulating kinase 1 (ASK1) inhibitor with a pIC₅₀ of 8.3, has been evaluated as an experimental treatment for diabetic nephropathy and kidney fibrosis.

Liriodenine Spermatheridine; VLT045	Apoptosis	Cancer
Liriodenine (Spermatheridine; VLT045) is an aporphine alkaloid isolated from the plant Mitrephora sirikitiae and has anti-cancer activities . Liriodenine induces cell apoptosis, activates the intrinsic pathway by induction of caspase-3 and caspase-9 .

3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine	PKC p38 MAPK ROCK	Cancer
3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine (Compound 7) is an inhibitor of protein kinases, with IC₅₀s of 0.092, 0.26, 0.77 μM for PKC-α, ROCK, ASK1. 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine shows potent cytotoxicity against PC-3 cancer cells with an IC₅₀ value of 0.16 μM .

Cat. No.	Product Name	Target	Research Area

HY-P3420

NH2-ASK-COOH

Peptides Cancer

NH2-ASK-COOH is a oligopeptide compoused of Ala-Ser-Lys.

Cat. No.	Compare	Product Name	Species	Source

	ASK1 Protein, Human (His) MAP3K5; Mitogen-activated protein kinase kinase kinase 5; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5	Human	E. coli
	ASK1 protein is a key serine/threonine kinase in the MAP kinase pathway, coordinating cellular responses to environmental changes and affecting cell fate, differentiation, and survival. ASK1 is a key player in apoptosis and promotes mitochondria-dependent caspase activation. ASK1 Protein, Human (His) is the recombinant human-derived ASK1 protein, expressed by E. coli , with C-6*His labeled tag. The total length of ASK1 Protein, Human (His) is 298 a.a., .

Cat. No.	Product Name	Application	Reactivity

HY-P82907

DBF4 Antibody (YA2652)

DBF4; ASK; DBF4A; ZDBF1; Protein DBF4 homolog A; Activator of S phase kinase; Chiffon homolog A; DBF4-type zinc finger-containing protein 1
WB Human

ASK1 Antibody (YA609)	WB, ICC/IF, IHC-P, FC	Human, Mouse
ASK1 Antibody (YA609) is a non-conjugated and Rabbit origined monoclonal antibody about 155 kDa, targeting to ASK1. It can be used for WB,ICC/IF,IHC-P,FC assays with tag free, in the background of Human, Mouse.

ASK1 Antibody MAP3K5; ASK1; MAPKKK5; MEKK5; Mitogen-activated protein kinase kinase kinase 5; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5	WB, IHC-P, ICC/IF, FC	Human, Mouse
ASK1 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 155 kDa, targeting to ASK1. It can be used for WB,IHC-P,ICC/IF,FC assays with tag free, in the background of Human, Mouse.

*Phospho-ASK1 (Ser966) Antibody* MAP3K5; ASK1; MAPKKK5; MEKK5; Mitogen-activated protein kinase kinase kinase 5; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5	WB, IHC-P	Human, Mouse, Rat
Phospho-ASK1 (Ser966) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 155 kDa, targeting to Phospho-ASK1 (Ser966). It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

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