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Results for "

ATPases

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Na+/K+ ATPase (41) Akt (1) Antibiotic (14) Apoptosis (44) Atg8/LC3 (1) ATP Synthase (4) Autophagy (24) Bacterial (39) BCRP (1) Beclin1 (1) Calcium Channel (16) Calmodulin (1) CDK (2) CFTR (1) Cholinesterase (ChE) (1) Cytochrome P450 (2) DNA/RNA Synthesis (7) Dynamin (1) E1/E2/E3 Enzyme (1) Endogenous Metabolite (15) Epigenetic Reader Domain (10) Estrogen Receptor/ERR (5) Fluorescent Dye (3) Fungal (12) GSK-3 (2) Hedgehog (1) HIF/HIF Prolyl-Hydroxylase (1) HIV (1) HSP (19) HSV (6) IFNAR (1) Influenza Virus (1) IRAK (2) Isotope-Labeled Compounds (14) Kinesin (6) Ligands for Target Protein for PROTAC (3) LXR (1) MDM-2/p53 (1) Microtubule/Tubulin (3) Mitophagy (2) Myosin (7) Necroptosis (1) NF-κB (3) NOD-like Receptor (NLR) (3) Oxidative Phosphorylation (4) P-glycoprotein (4) P2X Receptor (1) p97 (5) Parasite (7) Phosphatase (5) Phosphodiesterase (PDE) (2) PKC (1) Potassium Channel (5) PROTACs (3) Proton Pump (64) RSV (1) SARS-CoV (7) SGLT (1) Sodium Channel (1) SphK (1) TGF-beta/Smad (1) Thyroid Hormone Receptor (1) TOPK (2) Topoisomerase (1) ULK (1) VSV (1)
By Research Areas:	Cancer (120) Cardiovascular Disease (28) Endocrinology (15) Infection (48) Inflammation/Immunology (47) Metabolic Disease (35) Neurological Disease (24)
Click Chemistry:	Alkynes (1)

277

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: Na+/K+ ATPase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N1446B

Sodium oleate 15+ Cited Publications Oleic acid sodium; 9-cis-Octadecenoic acid sodium; 9Z-Octadecenoic acid sodium	Na+/K+ ATPase Apoptosis	Metabolic Disease Cancer
Sodium oleate (Oleic acid sodium) is an abundant monounsaturated fatty acid sodium . Sodium oleate is a Na ⁺/K ⁺ ATPase activator .

HY-146074

*RUVBL1/2 ATPase-IN-1*	Others	Cancer
RUVBL1/2 ATPase-IN-1 (compound 18) is a potent and selective inhibitor of RUVBL1/2 ATPase with IC₅₀ values of 6.0 and 7.7 μM, respectively. RUVBL1 and RUVBL2 are highly conserved AAA ATPases (ATPases Associated with various cellular Activities) and highly relevant to the progression of cancer. RUVBL1/2 ATPase-IN-1 has the potential for the research of cancer diseases .

HY-N6574

Marinobufogenin	Na+/K+ ATPase	Cardiovascular Disease Neurological Disease Metabolic Disease
Marinobufogenin is a strong inhibitor of Na ⁺/K ⁺ ATPase that has been identified in mammalian plasma .

HY-145415

W13

Bacterial Infection

W13 is a potent MsbA inhibitor. W13 is an ATPase stimulator with an EC₅₀ of 5.5 µM .
HY-N12414

Apicularen A

Others Cancer

Apicularen A is a macrolide isolated from the mucoid bacterium Chondrosporium spp. Apicularen A is also a highly selective inhibitor of vesicular ATPase .

W13	Bacterial	Infection
W13 is a potent MsbA inhibitor. W13 is an *ATPase* stimulator with an EC₅₀ of 5.5 µM .

Apicularen A	Others	Cancer
Apicularen A is a macrolide isolated from the mucoid bacterium Chondrosporium spp. Apicularen A is also a highly selective inhibitor of vesicular ATPase .

HY-131873

Dynapyrazole-A	Dynamin	Infection
Dynapyrazole A is a specific inhibitor of microtubule dynamin that specifically inhibits the ATPase activity of microtubule-stimulated dynamin without blocking microtubule-independent basal activity .

HY-128482

Diazobenzenesulfonic acid

4-Sulfobenzenediazonium
Others Others

Diazobenzenesulfonic acid (4-Sulfobenzenediazonium) is an inhibitor of aliostericeffect for myosin ATPase 13 .

Diazobenzenesulfonic acid 4-Sulfobenzenediazonium	Others	Others
Diazobenzenesulfonic acid (4-Sulfobenzenediazonium) is an inhibitor of aliostericeffect for myosin ATPase 13 .

HY-150626

SARS-CoV-2 nsp13-IN-5	SARS-CoV	Infection
SARS-CoV-2 nsp13-IN-5 (compound C6) is a potent SARS-CoV-2 nsp13 inhibitor with IC₅₀ values of 50 and 55 μM for ssDNA ⁺ ATPase and ssDNA ^- ATPase. SARS-CoV-2 nsp13-IN-5 can be used for researching anti-COVID-19 .

HY-150632

SARS-CoV-2 nsp13-IN-6	SARS-CoV	Infection
SARS-CoV-2 nsp13-IN-6 (compound C5) is a potent SARS-CoV-2 non-structural protein 13 (nsp13) inhibitor with IC₅₀ values of 27 and 33 μM for ssDNA ⁺ ATPase and ssDNA ^- ATPase. SARS-CoV-2 nsp13-IN-6 can be used for researching anti-COVID-19 .

HY-120950

S-tram,tram-Farnesylated cysteine methyl ester	Others	Others
S-tram,tram-Farnesylated cysteine methyl ester is a multidrug resistance transporter activator. S-tram,tram-Farnesylated cysteine methyl ester acts by stimulating the multidrug resistance transporter *ATPase* activity and competing for drug binding .

HY-123872

MSC1094308	p97	Cancer
MSC1094308 is a non-competitive and reversible VPS4B/p97 (VCP) (I/II type AAA ATPase) allosteric inhibitor, with IC₅₀ values of 0.71 μM and 7.2 μM for VPS4B and p97, respectively . MSC1094308 inhibits the D2 ATPase activity by binding to a agentable hotspot of p97. MSC1094308 can be used in study of cancer .

HY-W754708

Ouabagenin	LXR Na+/K+ ATPase	Cardiovascular Disease
Ouabagenin is a naturally occurring LXR ligand with LXR selective agonist activity. Ouabagenin acts as an EC 3.6.3.9 (Na(+)/K(+)- transport ATPase) inhibitor .

HY-15098

Apoptozole 5+ Cited Publications Apoptosis Activator VII	HSP Apoptosis	Cancer
Apoptozole (Apoptosis Activator VII) is an inhibitor of the ATPase domain of Hsc70 and Hsp70, with K_ds of 0.21 and 0.14 μM, respectively, and can induce apoptosis.

HY-W011102

S-Trityl-L-cysteine NSC 83265; S-Tritylcysteine; 3-Tritylthio-L-alanine	Kinesin Apoptosis	Cancer
S-Trityl-L-cysteine (NSC 83265) is a selective and allosteric kinesin Eg5 inhibitor with an IC₅₀ of 1 μM for the inhibition of basal ATPase activity and 140 nM for the microtubule-activated ATPase activity. S-Trityl-L-cysteine has antitumor activities .

HY-122632

Ciliobrevin D 1 Publications Verification	Hedgehog	Cancer
Ciliobrevin D is a cell-permeable, reversible and specific inhibitor of AAA+ ATPase motor cytoplasmic dynein. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation. Ciliobrevin D inhibits dynein-dependent microtubule gliding and ATPase activity in vitro .

HY-150622

SARS-CoV-2 nsp13-IN-1	SARS-CoV	Infection
SARS-CoV-2 nsp13-IN-1 (compound C1) is a potent nsp13 (non-structural protein 13) inhibitor. SARS-CoV-2 nsp13-IN-1 only inhibits nsp13 ssDNA ⁺ ATPase, with an IC₅₀ of 6 μM. SARS-CoV-2 nsp13-IN-1 does not inhibit ssDNA ^- ATPase. SARS-CoV-2 nsp13-IN-1 can be used for COVID-19 research .

HY-111002

Displurigen NSC375009	HSP	Others
Displurigen (NSC375009) disrupts human embryonic stem cell pluripotency by targeting HSPA8. Displurigen inhibits ATPase activity of HSP70 (IC₅₀ = 225 μM) .

HY-138820

SW02	HSP	Neurological Disease
SW02 is a potent activator of *ATPase* activity of Hsp70, with an EC₅₀ of 150 μM. SW02 leads to accumulation of both total tau and phosphorylated tau (pTau) .

HY-144896

FHT-1015 1 Publications Verification	Epigenetic Reader Domain	Cancer
FHT-1205 is a potent SMARCA4/SMARCA2 ATPase (BRG1 and BRM) inhibitor with IC₅₀s of ≤10 nM (WO2020160180A1; compound 67) .

HY-144897

FHT-1204

Epigenetic Reader Domain Cancer

FHT-1204 is a potent SMARCA4/SMARCA2 ATPase (BRG1 and BRM) inhibitor with IC₅₀s of ≤10 nM (WO2020160180A1; compound 70) .

FHT-1204	Epigenetic Reader Domain	Cancer
FHT-1204 is a potent SMARCA4/SMARCA2 ATPase (BRG1 and BRM) inhibitor with IC₅₀s of ≤10 nM (WO2020160180A1; compound 70) .

HY-16690

BTS 2 Publications Verification N-Benzyl-p-toluenesulfonamide; N-Tosylbenzylamine	Myosin	Others
BTS (N-Benzyl-p-toluenesulfonamide) is a potent and selective inhibitor of skeletal muscle myosin II subfragment 1 (S1) ATPase activity, with an IC₅₀s of ~5 µM for actin- and Ca ²⁺-stimulated myosin S1 ATPase. BTS specifically inhibits the contraction of fast skeletal muscle fibers .

HY-122815

Fusicoccin Fusicoccin A	Apoptosis	Cancer
Fusicoccin (Fusicoccin A), a fungal pytotoxin, is a stabilizer of specific 14-3-3 protein-protein interactions. Fusicoccin sabilizes H ⁺-ATPase/14-3-3 cmplex in pants, maintaining the enzyme in activated state. Fusicoccin also stabilizes 14-3-3 protein interactions with binding partners containing a C-terminal 14-3-3 recognition motif (a mode 3 motif), such as ERα, GPIbα, TASK3, CTFR, and p53. Fusicoccin induces apoptosis in cancer cells and has anticancer activity .

HY-152949

Myosin V-IN-1	Myosin	Neurological Disease
Myosin V-IN-1 (compound 8) is a potent and selective Myosin V inhibitor, with a K_i of 6 μM. Myosin V-IN-1 shows acute inhibition of myosin V. Myosin V-IN-1 slows the actin-activated myosin V ATPase by specifically inhibiting ADP release from the actomyosin complex .

HY-W003467

Rabeprazole Sulfide	Proton Pump Bacterial	Infection Inflammation/Immunology
Rabeprazole Sulfide is an active metabolite of Rabeprazole. Rabeprazole is a proton pump inhibitor that suppresses gastric acid secretion through an interaction with (H ⁺/K ⁺)-ATPase in gastric parietal cells. Rabeprazole markedly inhibits the motility of *H. pylori*. Rabeprazole has the potential for various peptic diseases treatment .

HY-N2877

Annonacin	Potassium Channel Sodium Channel Na+/K+ ATPase Calcium Channel	Neurological Disease
Annonacin is an Acetogenin and promotes cytotoxicity via a pathway inhibiting the mitochondrial complex. Annonacin is the active agent found in Annona muricata to act as an inhibitor of sodium/potassium (NKA) and *sarcoplasmic reticulum (SERCA) ATPase* pumps** .

HY-124776

NPD8733	Others	Cancer
NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration. NPD8733 specifically binds to valosin-containing protein (VCP)/p97, a member of the ATPase-associated with diverse cellular activities (AAA+) protein family. NPD8733 has the potential for the research of cancer diseases .

HY-143296

SphK1-IN-1	SphK	Cancer
SphK1-IN-1 (compound 48) is a SphK1 inhibitor with effective antitumor activity. SphK1-IN-1 inhibits SphK1 ATPase with an IC₅₀ value of 4.02 μM. SphK1-IN-1 can be used for the research of cancer .

HY-D1435

Oxonol VI	Na+/K+ ATPase	Neurological Disease
Oxonol VI acts as an optical indicator for membrane potentials in lipid vesicles. Oxonol VI is suitable for detecting changes of membrane potential associated with the activity of the (Na ⁺ + K ⁺)-ATPase in reconstituted vesicles .

HY-145416

G247	Bacterial	Infection
G247 is a specific MsbA inhibitor. G247 acts as a transmembrane domains (TMDs) wedge, symmetrically increasing nucleotide-binding domains (NBDs) separation and preventing conformational transition of MsbA. G247 suppresses ATPase activity by increasing inter-NBD distance .

HY-12861

CB-5083 10+ Cited Publications	p97	Cancer
CB-5083 is a first-in-class, potent, selective, and orally bioavailable inhibitor of the p97 AAA ATPase/VCP. CB-5083 selectively inhibits p97 through its D2 site with the IC₅₀ of 11 nM 。

HY-124805

MAL3-101	HSP	Cancer
MAL3-101 is a potent HSP70 allosteric inhibitor. MAL3-101 inhibits HSP70 ATPase activity by blocking Hsp40 co-chaperone interaction. MAL3-101 can be used for researching muscle invasive bladder cancer (MIBC) .

HY-150206

NLRP3-IN-13	NOD-like Receptor (NLR)	Neurological Disease Inflammation/Immunology
NLRP3-IN-13 (Compound C77 in reference patent) is a selective and potent NLRP3 inhibitor (IC₅₀: 2.1 μM). NLRP3-IN-13 inhibits NLRP3 andNLRC4 inflammasomes, and inhibits NLRP3-mediated IL-1β production. NLRP3-IN-13 also inhibits NLRP3 ATPase activity. NLRP3-IN-13 can be used in the research of neuroinflammatory disorders .

HY-17421

Tenatoprazole TU-199	Proton Pump	Infection Inflammation/Immunology
Tenatoprazole (TU-199) is an orally active imidazopyridine-based proton pump inhibitor with a prolonged plasma half-life. Tenatoprazole inhibits hog gastric H ⁺/K ⁺-ATPase activity with an IC₅₀ of 6.2 μM. Tenatoprazole blocks the interaction of ubiquitin with the ESCRT-1 factor Tsg101, inhibits production of several enveloped viruses, including EBV .

HY-13757AS

Tamoxifen-d5 ICI 47699-d5; (Z)-Tamoxifen-d₅; trans-Tamoxifen-d₅	Estrogen Receptor/ERR HSP Autophagy Apoptosis	Cancer
Tamoxifen-d₅ is a deuterium labeled Tamoxifen. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM). Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity[1][2].

HY-116683

116-9e MAL2-11B	HSP DNA/RNA Synthesis	Infection Cancer
116-9e (MAL2-11B) is a Hsp70 co-chaperone DNAJA1 inhibitor. 116-9e inhibits Simian Virus 40 (SV40) replication and DNA synthesis. 116-9e inhibits tumor antigen (TAg)’s endogenous ATPase activity and the TAg-mediated activation of Hsp70 .

HY-P3278

Caloxin 2A1	Proton Pump	Metabolic Disease
Caloxin 2A1 is an extracellular *plasma membrane Ca ²⁺-ATPase* (PMCA)** peptide inhibitor. Caloxin 2A1 does not affect basal Mg ²⁺-ATPase or Na ⁺-K ⁺-ATPase .

HY-P3278A

Caloxin 2A1 TFA 1 Publications Verification	Proton Pump	Metabolic Disease
Caloxin 2A1 TFA is an extracellular *plasma membrane Ca ²⁺-ATPase* (PMCA)** peptide inhibitor. Caloxin 2A1 TFA does not affect basal Mg ²⁺-ATPase or Na ⁺-K ⁺-ATPase .

HY-130004

MsbA-IN-6	Antibiotic Bacterial	Infection
MsbA-IN-6 is a potent inhibitor of MsbA. MsbA-IN-6 is an antibiotic. Gram-negative ATP-binding cassette (ABC) transporter MsbA, an essential inner membrane protein, transports lipopolysaccharide from the inner leaflet to the periplasmic face of the inner membrane. MsbA-IN-6 kills Escherichia coli through inhibition of its ATPase and transport activity, with no loss of activity against clinical multidrug-resistant strains .

HY-110185

NSC 617145	DNA/RNA Synthesis	Cancer
NSC 617145 is a selective werner syndrome helicase (WRN) helicase inhibitor with an IC₅₀ value of 230 nM. NSC 617145 inhibits WRN ATPase, and induces double-strand breaks (DSB) and chromosomal abnormalities. NSC 617145 shows selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD helicases .

HY-P3711

SPAI-1	Na+/K+ ATPase	Others
SPAI-1 is a specific inhibitor for monovalent cation transporting ATPases. SPAI-1 is a peptide isolated from porcine duodenum, inhibits Na ⁺, K ⁺-ATPase and H ⁺, K ⁺-ATPase in vitro, stimulates Mg ²⁺-ATPase .

HY-119374

BRM/BRG1 ATP Inhibitor-1 15+ Cited Publications	Epigenetic Reader Domain	Cancer
BRM/BRG1 ATP Inhibitor-1 (compound 14) is an orally active allosteric dual brahma homolog (BRM)/SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 2 (SMARCA2) and brahma related gene 1 (BRG1)/SMARCA4 ATPase activity inhibitor, both IC₅₀s are below 0.005 µM. BRM/BRG1 ATP Inhibitor-1 has anticancer activity .

HY-112661

PC-766B Antibiotic PC-766B	Antibiotic Bacterial Fungal	Infection Cancer
PC-766B is a macrolide antibiotic. PC-766B is active against Gram-positive bacteria, and some fungi and yeasts, but inactive against Gram-negative bacteria. PC-766B shows antitumor activity against murine tumor cells. PC-766B has weak inhibitory activity against Na ⁺, K ⁺-ATPase .

HY-B0656

Rabeprazole 2 Publications Verification LY307640	Proton Pump Apoptosis Bacterial	Inflammation/Immunology Cancer
Rabeprazole (LY307640) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H ⁺/K ⁺-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC₅₀ of 0.3 μM. Rabeprazole can be used for the research of gastric ulcerations and gastroesophageal reflux .

HY-B0656A

Rabeprazole sodium 2 Publications Verification LY307640 sodium	Proton Pump Apoptosis Bacterial	Inflammation/Immunology Cancer
Rabeprazole sodium (LY307640 sodium) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H ⁺/K ⁺-ATPase. Rabeprazole sodium induces apoptosis. Rabeprazole sodium acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC₅₀ of 0.3 μM. Rabeprazole sodium can be used for the research of gastric ulcerations and gastroesophageal reflux .

HY-B0656S

Rabeprazole-d4 LY307640-d₄	Proton Pump Apoptosis	Inflammation/Immunology Cancer
Rabeprazole-d₄ is a deuterium labeled Rabeprazole. Rabeprazole is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole can be used for the research of gastric ulcerations and gastroesophageal reflux[1][2][3].

HY-148041

ATPase-IN-2	Others	Others
ATPase-IN-2 is an *ATPase* inhibitor with an IC₅₀ value of 0.9 μM. ATPase-IN-2 inhibits C. difficile toxin B (TcdB) glycohydrolase activity with an AC₅₀ value of 30.91 μM. ATPase-IN-2 can be used for the research of ATP-related .

HY-N8493

Mycalolide B	Antibiotic	Others
Mycalolide-B is a specific inhibitor of actomyosin ATPase isolated from marine sponge. Mycalolide-B inhibits ATP-induced contraction and Mg ²⁺-ATPase activity in the absence of Ca ²⁺ .

HY-N6771

Cyclopiazonic acid 2 Publications Verification	Calcium Channel	Others
Cyclopiazonic acid (CPA), a neurotoxic secondary metabolite (SM) made by Aspergillus flavus, is an inhibitor of endoplasmic reticulum calcium ATPase (Ca ²⁺ATPase; SERCA) and a potent inducer of cell death in plants .

HY-N6745

Citreoviridin	Na+/K+ ATPase Apoptosis	Infection Cardiovascular Disease
Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na ⁺/K ⁺-ATPase whereas in microsomes, both Na ⁺/K ⁺-ATPase and Mg ²⁺-ATPase activities are significantly stimulated in a dose-dependent manner . Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells .

HY-135110

Rp-8-Br-cGMPS sodium salt Rp-8-bromo-Cyclic GMPS sodium salt	Calcium Channel	Metabolic Disease
Rp-8-Br-cGMPS (Rp-8-bromo-Cyclic GMPS) sodium salt is a potent Ca ²⁺-ATPase activator. Rp-8-Br-cGMPS sodium salt mediates cytosolic Ca ²⁺ reduction by activating Ca ²⁺-ATPase and subsequently removing Ca ²⁺ from the cell .

Cat. No.	Product Name	Target	Research Area

HY-P3278A

Caloxin 2A1 TFA 1 Publications Verification	Proton Pump	Metabolic Disease
Caloxin 2A1 TFA is an extracellular *plasma membrane Ca ²⁺-ATPase* (PMCA)** peptide inhibitor. Caloxin 2A1 TFA does not affect basal Mg ²⁺-ATPase or Na ⁺-K ⁺-ATPase .

HY-P5965

BiP substrate

Peptides Others

BiP substrate is a peptide substrate of BiP that can be used to measure the BiP ATPase activity .

HY-P3278

Caloxin 2A1	Proton Pump	Metabolic Disease
Caloxin 2A1 is an extracellular *plasma membrane Ca ²⁺-ATPase* (PMCA)** peptide inhibitor. Caloxin 2A1 does not affect basal Mg ²⁺-ATPase or Na ⁺-K ⁺-ATPase .

HY-P3711

SPAI-1	Na+/K+ ATPase	Others
SPAI-1 is a specific inhibitor for monovalent cation transporting ATPases. SPAI-1 is a peptide isolated from porcine duodenum, inhibits Na ⁺, K ⁺-ATPase and H ⁺, K ⁺-ATPase in vitro, stimulates Mg ²⁺-ATPase .

HY-P6008

Myoregulin MLN peptide	Calcium Channel	Cardiovascular Disease
Myoregulin (MLN peptide) is a member of the regulin family. Myoregulin regulates muscle performance by modulating intracellular calcium handling. Myoregulin interactes directly with sarcoplasmic reticulum Ca ²⁺-ATPase (SERCA) and impedinf Ca ²⁺ uptake into the sarcoplasmic reticulum .

HY-P6008A

Myoregulin TFA MLN peptide TFA	Calcium Channel	Cardiovascular Disease
Myoregulin (MLN peptide) TFA is a member of the regulin family. Myoregulin TFA regulates muscle performance by modulating intracellular calcium handling. Myoregulin TFA interactes directly with sarcoplasmic reticulum Ca ²⁺-ATPase (SERCA) and impedinf Ca ²⁺ uptake into the sarcoplasmic reticulum .

HY-P5570

Aurein 2.3

Antibiotic Bacterial Infection

Aurein 2.3 is an antibiotic antimicrobial peptide. Aurein 2.3 partially inhibits E.coli ATPase activity and inhibits cell growth .

HY-P2657

Verucopeptin	HIF/HIF Prolyl-Hydroxylase Proton Pump Endogenous Metabolite	Cancer
Verucopeptin is a potent HIF-1 (IC50=0.22 μM) inhibitor and decreases the expression of HIF-1 target genes and HIF-1α protein levels. Verucopeptin strongly inhibits v-ATPase activity by directly targeting the v-ATPase ATP6V1G subunit but not ATP1V1B2 or ATP6V1D. Verucopeptin exhibits antitumor activity against multidrug resistance (MDR) cancers and can be used for cancer research.

HY-125486

Reversin 121	P-glycoprotein	Cancer
Reversin 121 is a P-glycoprotein inhibitor. Reversin 121 increases the ATPase activity of MDR1. Reversin 121 reverses P-glycoprotein-mediated multidrug resistance. Reversin 121 can be used in the research of cancers .

HY-P4856

pTH-Related Protein (1-40) (human, mouse, rat)	PKC	Endocrinology
pTH-Related Protein (1-40) (human, mouse, rat) stimulates calcium uptake in rat intestinal cells through PTHR1 receptor and PKCα/β signaling pathways. pTH-Related Protein (1-40) up-regulates parathyroid hormone 1 receptor (PTHR1) protein, four transcellular calcium transporters, potential vanillin member 6 (TRPV6), calcium-binding protein-D9K (CaBP-D9k), sodium-calcium Exchanger 1 (NCX1) and plasma membrane calcium ATPase 1 (PMCA1) .

HY-P3617

Glucagon (22-29)	Peptides	Metabolic Disease
Glucagon (22-29) is partial agonist of Glucagon (19–29). Glucagon specifically inhibits the Ca ²⁺ pump in liver plasma membranes independently of adenylate cyclase activation .

HY-P1565

Transdermal Peptide Disulfide TD 1 Disulfide(peptide)	Na+/K+ ATPase	Inflammation/Immunology
Transdermal Peptide Disulfide (TD 1 Disulfide(peptide)) is a 11-amino acid peptide, binds toNa ⁺/K ⁺-ATPase beta-subunit (ATP1B1), and mainly interacts with the C-terminus of ATP1B1. Transdermal Peptide Disulfide can enhance the transdermal delivery of many macromolecules .

HY-P1565A

Transdermal Peptide Disulfide TFA TD 1 Disulfide(peptide) TFA	Na+/K+ ATPase	Others
Transdermal Peptide Disulfide TFA (TD 1 Disulfide(peptide) TFA) is a 11-amino acid peptide, binds to *Na ⁺/K ⁺-ATPase* beta-subunit (ATP1B1), and mainly interacts with the C-terminus of ATP1B1**. Transdermal Peptide Disulfide TFA can enhance the transdermal delivery of many macromolecules .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1446B

Sodium oleate 15+ Cited Publications Oleic acid sodium; 9-cis-Octadecenoic acid sodium; 9Z-Octadecenoic acid sodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Na+/K+ ATPase Apoptosis
Sodium oleate (Oleic acid sodium) is an abundant monounsaturated fatty acid sodium . Sodium oleate is a Na ⁺/K ⁺ ATPase activator .

HY-N6574

Marinobufogenin	Classification of Application Fields Neurological Disease Animals Source classification Metabolic Disease Disease Research Fields Steroids	Na+/K+ ATPase
Marinobufogenin is a strong inhibitor of Na ⁺/K ⁺ ATPase that has been identified in mammalian plasma .

HY-122815

Fusicoccin Fusicoccin A	Microorganisms Classification of Application Fields Terpenoids Source classification Diterpenoids Disease Research Fields Cancer	Apoptosis
Fusicoccin (Fusicoccin A), a fungal pytotoxin, is a stabilizer of specific 14-3-3 protein-protein interactions. Fusicoccin sabilizes H ⁺-ATPase/14-3-3 cmplex in pants, maintaining the enzyme in activated state. Fusicoccin also stabilizes 14-3-3 protein interactions with binding partners containing a C-terminal 14-3-3 recognition motif (a mode 3 motif), such as ERα, GPIbα, TASK3, CTFR, and p53. Fusicoccin induces apoptosis in cancer cells and has anticancer activity .

HY-N12414

Apicularen A	Structural Classification Natural Products Microorganisms Source classification	Others
Apicularen A is a macrolide isolated from the mucoid bacterium Chondrosporium spp. Apicularen A is also a highly selective inhibitor of vesicular ATPase .

HY-W754708

Ouabagenin	Structural Classification Microorganisms Cardiacglycosides Source classification Endogenous metabolite Steroids	LXR Na+/K+ ATPase
Ouabagenin is a naturally occurring LXR ligand with LXR selective agonist activity. Ouabagenin acts as an EC 3.6.3.9 (Na(+)/K(+)- transport ATPase) inhibitor .

HY-N2877

Annonacin	Natural Products Neurological Disease Classification of Application Fields Annona muricata Linn. Source classification Plants Annonaceae Disease Research Fields	Potassium Channel Sodium Channel Na+/K+ ATPase Calcium Channel
Annonacin is an Acetogenin and promotes cytotoxicity via a pathway inhibiting the mitochondrial complex. Annonacin is the active agent found in Annona muricata to act as an inhibitor of sodium/potassium (NKA) and *sarcoplasmic reticulum (SERCA) ATPase* pumps** .

HY-112661

PC-766B Antibiotic PC-766B	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Disease Research Fields Cancer	Antibiotic Bacterial Fungal
PC-766B is a macrolide antibiotic. PC-766B is active against Gram-positive bacteria, and some fungi and yeasts, but inactive against Gram-negative bacteria. PC-766B shows antitumor activity against murine tumor cells. PC-766B has weak inhibitory activity against Na ⁺, K ⁺-ATPase .

HY-N8493

Mycalolide B	Alkaloids Structural Classification Classification of Application Fields Animals Other Alkaloids Source classification Other Diseases Disease Research Fields	Antibiotic
Mycalolide-B is a specific inhibitor of actomyosin ATPase isolated from marine sponge. Mycalolide-B inhibits ATP-induced contraction and Mg ²⁺-ATPase activity in the absence of Ca ²⁺ .

HY-N6771

Cyclopiazonic acid 2 Publications Verification	Alkaloids Structural Classification Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Other Diseases Disease Research Fields Indole Alkaloids	Calcium Channel
Cyclopiazonic acid (CPA), a neurotoxic secondary metabolite (SM) made by Aspergillus flavus, is an inhibitor of endoplasmic reticulum calcium ATPase (Ca ²⁺ATPase; SERCA) and a potent inducer of cell death in plants .

HY-N6745

Citreoviridin	Cardiovascular Disease Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Na+/K+ ATPase Apoptosis
Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na ⁺/K ⁺-ATPase whereas in microsomes, both Na ⁺/K ⁺-ATPase and Mg ²⁺-ATPase activities are significantly stimulated in a dose-dependent manner . Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells .

HY-108970

Bafilomycin D	Structural Classification Natural Products Microorganisms Source classification	Proton Pump Bacterial Fungal
Bafilomycin D is a specific inhibitor of vacuolar-type ATPase (V-ATPase). Bafilomycin D has antibacterial, antifungal, insecticidal, herbicidal, and cytotoxic activities .

HY-16589

Oligomycin A 25+ Cited Publications MCH 32	Infection Structural Classification Microorganisms Antifungal Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Disease Research Disease Research Fields	ATP Synthase Fungal Antibiotic
Oligomycin A (MCH 32), created by Streptomyces, acts as a mitochondrial *F₀F₁-ATPase* inhibitor, with a K_i of 1 μM; Oligomycin A shows anti-fungal activity.

HY-N12413

Apicularen B	Structural Classification Natural Products Microorganisms Source classification	Proton Pump
Apicularen B is a *V-ATPase* inhibitor and cytotoxic macrolide that can be obtained from the myxobacterium Archangium gephyra. Apicularen B can be used in the study of V-ATPase-related diseases, such as osteopetrosis .

HY-N10239

Aquastatin A	Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Metabolic Disease Disease Research Fields	Others
Aquastatin A is an inhibitor of mammalian adenosine triphosphatases. Aquastatin A is isolated from a fungus identified as Fusarium aquaeductuum. Aquastatin A inhibits Na+/K(+)-ATPase with an IC₅₀ value of 7.1 μM, and H+/K(+)-ATPase with an apparent IC₅₀ value of 6.2 μM .

HY-B0542

Ouabain Octahydrate 15+ Cited Publications Acocantherine; G-Strophanthin	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	Na+/K+ ATPase Autophagy
Ouabain Octahydrate is an inhibitor of Na ⁺/K ⁺-ATPase, used for the treatment of congestive heart failure.

HY-13719

Oleandrin 2 Publications Verification PBI-05204	Apocynaceae Classification of Application Fields Source classification Nerium indicum Mill. Plants Disease Research Fields Steroids Cancer	Na+/K+ ATPase
Oleandrin (PBI-05204) inhibits the Na ⁺, K ⁺-ATPase activity with an IC₅₀ of 620 nM.

HY-13433

Thapsigargin 50+ Cited Publications	Infection Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Umbelliferae Disease Research Fields Cancer Thapsia garganica L.	Calcium Channel SARS-CoV Apoptosis
Thapsigargin, an endoplasmic reticulum (ER) stress inducer, is an inhibitor of microsomal Ca ²⁺-ATPase. Thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types .

HY-114252

Strophanthidin	Cardiovascular Disease Classification of Application Fields Source classification Plants Brassicaceae Disease Research Fields Steroids Erysimum cheiranthoides Linn.	Na+/K+ ATPase
Strophanthidin is a naturally available cardiac glycoside . Strophanthidin 0.1 and 1 nmol/L increases and 1~100 µmol/L inhibits the *Na+/K+-ATPase* activities, but Strophanthidin 10 and 100 nmol/L does not affect *Na+/K+-ATPase* activities in cardiac sarcolemmal . Strophanthidin increases both diastolic and systolic intracellular Ca ²⁺ concentration .

HY-N11690

Oleandrigenin	Apocynaceae Structural Classification Natural Products Source classification Nerium indicum Mill. Plants	Na+/K+ ATPase
Oleandrigenin is a potent cardiotonic steroid. Oleandrigenin shows Na ⁺/K ⁺-ATP-ase inhibiting and cytotoxic activities .

HY-125707

Concanamycin B MCH 210	Structural Classification Natural Products Microorganisms Source classification	Proton Pump Antibiotic
Concanamycin B is a macrolide antibiotic, which can inhibit the cavitation type *H+-ATPases, and the IC₅₀* value is 5 nM .

HY-130173

Bafilomycin C1	Infection Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Source classification Antibacterial Disease Research Anticancer Disease Research Fields Cancer	Bacterial Fungal Na+/K+ ATPase Apoptosis Antibiotic
Bafilomycin C1 is a macrolide antibiotic isolated from Streptomyces sp. Bafilomycin C1 is a potent, specific and reversible inhibitor of vacuolar-type H ⁺-ATPases (V-ATPases). Bafilomycin C1 inhibits growth of gram-positive bacteria and fungi . Bafilomycin C1 induces cell apoptosis and can be used for the study of hepatocellular carcinoma (HCC) .

HY-W013706

Inosine-5'-triphosphate trisodium salt	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Inosine-5'-triphosphate trisodium salt is a nucleoside triphosphate and functions as an substrate for ATPases and GTPases .

HY-100558

Bafilomycin A1 Maximum Cited Publications 369 Publications Verification BafA1	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields	Proton Pump Autophagy Antibiotic Bacterial Apoptosis
Bafilomycin A1 (BafA1) is a specific and reversible inhibitor of vacuolar H ⁺-ATPase (V-ATPase) with IC₅₀ values of 4-400 nmol/mg. Bafilomycin A1, a macrolide antibiotic, is also used as an autophagy inhibitor at the late stage. Bafilomycin A1 blocks autophagosome-lysosome fusion and inhibits acidification and protein degradation in lysosomes of cultured cells. Bafilomycin A1 induces apoptosis .

HY-N0143

Phlorizin 5+ Cited Publications Floridzin	Structural Classification Flavonoids Classification of Application Fields Source classification Malus pumila Mill. Rosaceae Phenols Polyphenols Metabolic Disease Plants Dihydrochalcones Disease Research Fields	SGLT Na+/K+ ATPase
Phlorizin (Floridzin) is a non-selective SGLT inhibitor with K_is of 300 and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na ⁺/K ⁺-ATPase inhibitor.

HY-N2033

Chebulinic acid 1 Publications Verification	Infection Structural Classification Classification of Application Fields Combretaceae Source classification Phenols Polyphenols Terminalia chebula Retz. Plants Disease Research Fields	DNA/RNA Synthesis TGF-beta/Smad Proton Pump
Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.

HY-N2532

Diphyllin	Structural Classification Classification of Application Fields Source classification Lignans Dysosma versipellis (Hance) M. Cheng ex Ying Plants Infection Monophenols Phenols Phenylpropanoids Berberidaceae Inflammation/Immunology Disease Research Fields	VSV HIV Proton Pump Influenza Virus
Diphyllin is an arylnaphthalene lignan isolated from Justicia procumbens and is a potent HIV-1 inhibitor with an IC50 of 0.38 μM. Diphyllin is active against vesicular stomatitis virus (VSV) and influenza virus . Diphyllin is a vacuolar type H ⁺-ATPase (V-ATPase) inhibitor with an IC₅₀ value of 17 nM and inhibits lysosomal acidification in human osteoclasts . Diphyllin inhibits NO production with an IC₅₀ of 50 μM and has anticancer and anti-inflammatory activities .

HY-N2070

Acevaltrate 1 Publications Verification	Structural Classification Iridoids Terpenoids Source classification Valeriana officinalis Linn. Plants Valerianaceae	Na+/K+ ATPase
Acevaltrate inhibits the Na ⁺/K ⁺-ATPase activity in the rat kidney and brain hemispheres with IC₅₀s of 22.8 μM and 42.3 μM, respectively .

HY-N6738

Bafilomycin B1	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields	Bacterial Fungal Antibiotic
Bafilomycin B1 is a macrolide antibiotic isolated from Streptomyces sp, inhibits Gram-positive bacteria and fungi, and acts as an inhibitor of K ⁺-dependent ATPase of E. coli .

HY-N4184

Licoflavone B	Structural Classification Classification of Application Fields Flavones Glycyrrhiza inflata Batal. Source classification Plants Infection Flavonoids Leguminosae Phenols Polyphenols Glycyrrhiza uralensis Fisch. Disease Research Fields	Parasite
Licoflavone B is a flavonoid isolated from Glycyrrhiza inflata, inhibits S. mansoni *ATPase* (IC₅₀, 23.78 µM) and ADPase (IC₅₀, 31.50 µM) activity. Anti-schistosomiasis activity .

HY-N7031

(±)-Vasicine (±)-Peganine	Alkaloids Classification of Application Fields Zygophyllaceae Source classification Peganum harmala Linn. Plants Disease Research Fields Inflammation/Immunology	Proton Pump
(±)-Vasicine is the racemate of Vasicine. Vasicine (Peganine) significantly inhibits H ⁺-K ⁺-ATPase activity in vitro with an IC₅₀ of 73.47 μg/mL. Anti-ulcer activity. Vasicine shows significant anti-secretory, antioxidant and cytoprotective effect .

HY-136933

Gitoxin	Cardiovascular Disease Digitalis purpurea Linn. Classification of Application Fields Source classification Scrophulariaceae Plants Disease Research Fields Steroids	Na+/K+ ATPase
Gitoxin, a Na ⁺/K ⁺-ATPase inhibitor, usually appears as a result of metabolic degradation of Digitoxin, is just the hydroxyl (ZOH) group close to the C-17β position, which changes the pharmacokinetics and pharmacodynamics of these substances considerably .

HY-N10097

Chamigrenol	Structural Classification Cupressaceae Terpenoids Sesquiterpenes Source classification Plants Thujopsis dolabrata (Thunberg ex L. f.) Sieb. et Zucc.	Na+/K+ ATPase Bacterial
Chamigrenol is a Na ⁺/K ⁺-ATPase inhibitor with an IC₅₀ value of 15.9 μg/mL. Chamigrenol shows strong inhibitory activities against Gram-positive and Gram-negative bacteria except Escherichia coli, with MIC values of 50 µg/mL .

HY-141442

Dihydronovobiocin	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Bacterial Antibiotic
Dihydronovobiocin is a bacterial inhibitor and *ATPase* inhibitor that can bind to GyrB. Dihydronovobiocin can be used to study the interaction between coumarin antibiotics (such as Novobiocin, Chlorobiocin, and Coumermycin) and DNA gyrase. Dihydronovobiocin also has the potential to study bacterial infections .

HY-N0039

Ginsenoside Rb1 5 Publications Verification Gypenoside III	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae Cancer	Na+/K+ ATPase IRAK NF-κB Autophagy Mitophagy HSV
Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na ⁺, K ⁺-ATPase activity with an IC₅₀ of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65 .

HY-N10402

Norbatzelladine L	Alkaloids Microorganisms Source classification	Fungal Bacterial Parasite
Norbatzelladine L (Compound 2) is an inhibitor of the catalytic and functional activity of Pdr5p transporter. Norbatzelladine L inhibits Pdr5p ATPase activity with an IC₅₀ of 3.8 µM. Norbatzelladine L shows antifungal, antiparasitic, antiviral, antibacterial and antitumoral activities .

HY-D0199

Adenosine 5'-diphosphate disodium	Cardiovascular Disease Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Adenosine 5'-diphosphate disodium is a nucleoside diphosphate. Adenosine 5'-diphosphate disodium is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate disodium is a platelet aggregation agent for hemostasis and the development and extension of arterial thrombosis .

HY-W010791

Adenosine 5'-diphosphate sodium salt	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Adenosine 5'-diphosphate (ADP) sodium salt is a nucleoside diphosphate, which is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate sodium salt induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P_2T-purinoceptors .

HY-N10401

Batzelladine D	Infection Alkaloids Structural Classification Classification of Application Fields Animals Other Alkaloids Marine natural products Sponge Disease Research Fields Cancer	Fungal Bacterial Parasite
Batzelladine D (Compound 1) is an inhibitor of the catalytic and functional activity of Pdr5p transporter. Batzelladine D inhibits Pdr5p ATPase activity with an IC₅₀ of 7.1 µM. Batzelladine D shows antifungal, antiparasitic, antiviral, antibacterial and antitumoral activities .

HY-N9149

Cryptanoside A	Apocynaceae Triterpenes Structural Classification Terpenoids Source classification Plants Cryptolepis buchananii Roem. et Schult.	Na+/K+ ATPase Akt NF-κB
Cryptanoside A, a cardiac glycoside epoxide, can be isolated from the stems of Cryptolepis dubia. Cryptanoside A has potent cytotoxicity against cancer cells. Cryptanoside A also inhibits *Na+/K+-ATPase* activity. Cryptanoside A increases the expression of Akt and the p65 subunit of NF-κB .

HY-N0877

Bufalin 5+ Cited Publications	Structural Classification Classification of Application Fields Animals Source classification Disease Research Fields Steroids Cancer	Na+/K+ ATPase
Bufalin is an active component isolated from Chan Su, acts as a potent Na ⁺/K ⁺-ATPase inhibitor, binds to the subunit α1, α2 and α3, with K_d of 42.5, 45 and 40 nM, respectively . Anti-cancer activity .

HY-W010918

Adenosine 5'-diphosphate Adenosine diphosphate; ADP	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Disease markers Nervous System Disorder Endogenous metabolite Disease Research Fields Cardiovascular System Disorder	Endogenous Metabolite
Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P_2T-purinoceptors.

HY-126601

Malonganenone A	Infection Structural Classification Alkaloids Classification of Application Fields Animals Other Alkaloids Source classification Disease Research Fields	Parasite HSP
Malonganenone A is an antimalarial marine alkaloid that disrupts the interaction between PfHsp70-x and Hsp40. Malonganenone A inhibits plasmodial and not human Hsp70 ATPase activity (Hsp40-stimulated), and hindered the aggregation suppression activity of PfHsp70-x .

HY-126679

Apoptolidin	Natural Products Microorganisms Source classification Disease Research Fields Cancer	ATP Synthase Apoptosis
Apoptolidin is a polyketide isolated from Nocardiopsis bacteria . Apoptolidin is a selective mitochondrial F₁F_O ATPase inhibitor. Apoptolidin is an apoptosis inducer and induces apoptotic cell death in cells transformed with the adenovirus type 12 oncogenes including ElA (IC₅₀=10-17 ng/ml) but not in normal cells .

HY-N8265

Abyssinone V	Structural Classification Flavonoids Leguminosae Flavonones Source classification Erythrina melanacantha Taub. ex Harms Plants	HSV DNA/RNA Synthesis ATP Synthase
Abyssinone V is a prenylated flavonoid with predicted anti-viral activity. Abyssinone V can be isolated from the stem bark of Erythrina melanacantha. Abyssinone V possesses good pharmacodynamics properties. Abyssinone V is predicted to be antivirals including anti-herpes (HSV) agent, with mechanisms comprising inhibition of polymerase, ATPase and membrane integrity .

HY-N8441

Neriifolin 17β-Neriifolin	Apocynaceae Structural Classification Classification of Application Fields Cardiacglycosides Cerbera manghas Linn. Source classification Plants Inflammation/Immunology Disease Research Fields Steroids	Atg8/LC3 Na+/K+ ATPase Apoptosis Beclin1
Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na ⁺, K ⁺-ATPase. Neriifolin can target beclin 1, inhibits the formation of LC3-associated phagosomes and ameliorates experimental autoimmune encephalomyelitis (EAE) development. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells ^[2.

HY-N0039R

Ginsenoside Rb1 (Standard) Gypenoside III (Standard)	Panax ginseng C. A. Meyer Structural Classification Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae Cancer	Na+/K+ ATPase IRAK NF-κB Autophagy Mitophagy HSV
Ginsenoside Rb1 (Standard) is the analytical standard of Ginsenoside Rb1. This product is intended for research and analytical applications. Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na ⁺, K ⁺-ATPase activity with an IC₅₀ of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65 .

HY-N6778

Paxilline 5 Publications Verification	Alkaloids Structural Classification other families Microorganisms Neurological Disease Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Disease Research Fields Indole Alkaloids	Potassium Channel Calcium Channel
Paxilline is an indole alkaloid mycotoxin from Penicillium paxilli, acts as a potent BK channels inhibitor by an almost exclusively closed-channel block mechanism. Paxilline also inhibits the *sarco/endoplasmic reticulum Ca ²⁺ ATPase* (SERCA) with IC₅₀**s between 5 μM and 50 μM for differing isoforms. Paxilline possesses significant anticonvulsant activity .

HY-N6687

Calcimycin 5+ Cited Publications A-23187; Antibiotic A-23187	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Polyether Antibiotics	Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy Antibiotic
Calcimycin (A-23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin induces Ca ²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin induces apoptosis .

HY-117025A

Manzamine A hydrochloride 1 Publications Verification Keramamine A hydrochloride	Structural Classification Neurological Disease Classification of Application Fields Source classification Marine natural products Pyridine Alkaloids Indole Alkaloids Infection Alkaloids Piperidine Alkaloids Animals Sponge Disease Research Fields	GSK-3 CDK Parasite Proton Pump HSV Autophagy
Manzamine A hydrochloride, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC₅₀s of 10.2 μM and 1.5 μM, respectively. Manzamine A hydrochloride targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A hydrochloride has antimalarial and anticancer activities. Manzamine A hydrochloride also shows potent activity against HSV-1 .

HY-117025

Manzamine A Keramamine A	Infection Alkaloids Structural Classification Neurological Disease Classification of Application Fields Animals Marine natural products Sponge Disease Research Fields Cancer	GSK-3 CDK Parasite Proton Pump HSV Autophagy
Manzamine A, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC₅₀s of 10.2 μM and 1.5 μM, respectively. Manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A has antimalarial and anticancer activities. Manzamine A also shows potent activity against HSV-1 .

Cat. No.	Product Name	Chemical Structure

HY-13757AS

Tamoxifen-d5
Tamoxifen-d₅ is a deuterium labeled Tamoxifen. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM). Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity[1][2].

HY-B0656S

Rabeprazole-d4
Rabeprazole-d₄ is a deuterium labeled Rabeprazole. Rabeprazole is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole can be used for the research of gastric ulcerations and gastroesophageal reflux[1][2][3].

HY-100560S

Abscisic acid-d6

Abscisic acid-d₆ is deuterium labeled Abscisic acid. Abscisic acid inhibits proton pump (H+-ATPase)[1].
HY-N1446S5

Oleic acid-d9

Oleic acid-d₉ is deuterium labeled Oleic acid. Oleic acid is an abundant monounsaturated fatty acid. Oleic acid is a Na+/K+ ATPase activator[1][2].

HY-B0137AS

Prilocaine-d7 hydrochloride
Prilocaine-d₇ (hydrochloride) is deuterium labeled Prilocaine (hydrochloride). Prilocaine hydrochloride, an amino amide, is a Na, K-ATPase inhibitor. Prilocaine has neurotoxic effects[1][2].

HY-W008614S

Lansoprazole sulfone-d4

Lansoprazole sulfone-d₄ (AG-1813-d₄) is the deuterium labeled Lansoprazole sulfone. Lansoprazole sulfone-d₄ is an orally active and selective inhibitor of H ⁺, K ⁺-ATPase. Lansoprazole sulfone-d₄ can significantly stimulates gastric acid secretion by inhibiting H ⁺, K ⁺-ATPase. Lansoprazole sulfone-d₄ has potential applications in duodenal ulcer, gastric ulcer, gastroesophageal reflux disease and Zolinger Ellison disease .

HY-N1446S

Oleic acid-13C
Oleic acid- ¹³C is the ¹³C labeled Oleic acid. Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid[1]. Oleic acid is a Na+/K+ ATPase activator[2].

HY-N1446S3

Oleic acid-d17
Oleic acid-d₁₇ is the deuterium labeled Oleic acid. Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid[1]. Oleic acid is a Na+/K+ ATPase activator[2].

HY-N1446S2

Oleic acid-13C18
Oleic acid- ¹³C₁₈ is the ¹³C labeled Oleic acid. Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid[1]. Oleic acid is a Na+/K+ ATPase activator[2].

HY-N1446S1

Oleic acid-d2
Oleic acid-d₂) is the deuterium labeled Oleic acid. Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid[1]. Oleic acid is a Na+/K+ ATPase activator[2].

HY-N1446S4

Oleic acid-13C-1
Oleic acid- ¹³C-1 is the ¹³C labeled Oleic acid. Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid[1]. Oleic acid is a Na+/K+ ATPase activator[2].

HY-17023S

Esomeprazole-d6 sodium
Esomeprazole-d₆ sodium is the deuterium labeled Esomeprazole. Esomeprazole ((S)-Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H ⁺, K ⁺-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research .

HY-17021S

Esomeprazole-d3 sodium
Esomeprazole-d₃ (sodium) is the deuterium labeled Esomeprazole. Esomeprazole ((S)-Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H+, K+-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research[1][2][3].

HY-17021S1

Esomeprazole-d3
Esomeprazole-d₃ is deuterium labeled Esomeprazole. Esomeprazole ((S)-Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H+, K+-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research[1][2][3].

HY-A0213AS

Tiludronate-d5 sodium
Tiludronate-d₅ (sodium)mis the deuterium labeled Tiludronate disodium. Tiludronate (Tiludronic Acid) disodium, an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. Antiresorptive and anti-inflammatory properties[1][2][3][4].

HY-B0656AS

Rabeprazole-d4 sodium

Rabeprazole-d₄ (sodium) is the deuterium labeled Rabeprazole sodium. Rabeprazole sodium (LY307640 sodium) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole sodium induces apoptosis. Rabeprazole sodium acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole sodium can be used for the research of gastric ulcerations and gastroesophageal reflux[1][2][3].

HY-B0656AS1

Rabeprazole-d3 sodium

Rabeprazole-d₃ (sodium)mis the deuterium labeled Rabeprazole sodium. Rabeprazole sodium (LY307640 sodium) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole sodium induces apoptosis. Rabeprazole sodium acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole sodium can be used for the research of gastric ulcerations and gastroesophageal reflux[1][2][3].

HY-17507S

Pantoprazole-d6

Pantoprazole-d₆ is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI)[1]. Pantoprazole, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142)[3][4].

HY-17507S1

Pantoprazole-d3

Pantoprazole-d₃ is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI)[1]. Pantoprazole, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142)[3][4].

HY-W010918S

Adenosine 5'-diphosphate-d13 dilithium

Adenosine 5'-diphosphate-d₁₃ (Adenosine diphosphate-d₁₃ dilithium; ADP-d₁₃) dilithium is deuterium labeled Adenosine 5'-diphosphate (HY-W010918). Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P_2T-purinoceptors.

HY-W010918S1

Adenosine 5'-diphosphate-13C10 dilithium

Adenosine 5'-diphosphate- ¹³C₁₀ (Adenosine diphosphate- ¹³C₁₀ dilithium; ADP- ¹³C₁₀) dilithium is ¹³C-labeled Adenosine 5'-diphosphate (HY-W010918). Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P_2T-purinoceptors.

HY-W010918S2

Adenosine 5'-diphosphate-15N5 dilithium

Adenosine 5'-diphosphate- ¹⁵N₅ (Adenosine diphosphate- ¹⁵N₅ dilithium; ADP- ¹⁵N₅) dilithium is ¹⁵N labeled Adenosine 5'-diphosphate (HY-W010918). Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P_2T-purinoceptors.

HY-13757AS1

Tamoxifen-d3

Tamoxifen-d₃ is the deuterium labeled Tamoxifen[1]. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells[2][3][4]. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively[6]. Tamoxifen activates autophagy and induces apoptosis[5]. Tamoxifen also can induce gene knockout of CreER(T2) transgenic mouse[7].

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