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Acetaminophen cyp450 Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Adenosine Receptor (1) Anaplastic lymphoma kinase (ALK) (1) Apoptosis (1) Bacterial (5) Biochemical Assay Reagents (1) CCR (2) COX (6) CXCR (1) Cytochrome P450 (11) DNA/RNA Synthesis (1) Drug Metabolite (4) E1/E2/E3 Enzyme (1) Endogenous Metabolite (13) Endothelin Receptor (1) Ferroptosis (2) Fungal (1) FXR (1) GCGR (2) GHSR (1) GLP Receptor (2) HCV (2) HCV Protease (2) HDAC (1) Histamine Receptor (3) Histone Acetyltransferase (6) Interleukin Related (1) Isotope-Labeled Compounds (6) Necroptosis (1) Parasite (6) Phospholipase (1) Potassium Channel (1) Proteasome (1) Reactive Oxygen Species (2) SARS-CoV (2) Sodium Channel (2) Somatostatin Receptor (3) TNF Receptor (1) Toll-like Receptor (TLR) (1) Topoisomerase (1)
By Research Areas:	Cancer (18) Cardiovascular Disease (5) Infection (6) Inflammation/Immunology (15) Metabolic Disease (10) Neurological Disease (9)

By Targets:

5-HT Receptor (1)

Adenosine Receptor (1)

Anaplastic lymphoma kinase (ALK) (1)

Apoptosis (1)

Bacterial (5)

Biochemical Assay Reagents (1)

CCR (2)

COX (6)

CXCR (1)

Cytochrome P450 (11)

DNA/RNA Synthesis (1)

Drug Metabolite (4)

E1/E2/E3 Enzyme (1)

Endogenous Metabolite (13)

Endothelin Receptor (1)

Ferroptosis (2)

Fungal (1)

FXR (1)

GCGR (2)

GHSR (1)

GLP Receptor (2)

HCV (2)

HCV Protease (2)

HDAC (1)

Histamine Receptor (3)

Histone Acetyltransferase (6)

Interleukin Related (1)

Isotope-Labeled Compounds (6)

Necroptosis (1)

Parasite (6)

Phospholipase (1)

Potassium Channel (1)

Proteasome (1)

Reactive Oxygen Species (2)

SARS-CoV (2)

Sodium Channel (2)

Somatostatin Receptor (3)

TNF Receptor (1)

Toll-like Receptor (TLR) (1)

Topoisomerase (1)

By Research Areas:

Cancer (18)

Cardiovascular Disease (5)

Infection (6)

Inflammation/Immunology (15)

Metabolic Disease (10)

Neurological Disease (9)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0725S

Doxepin D3 Hydrochloride	Histamine Receptor Cytochrome P450	Neurological Disease
Doxepin-d₃ (hydrochloride) is a deuterium labeled Doxepin Hydrochloride. Doxepin hydrochloride is an orally active tricyclic antidepressant. Doxepin hydrochloride is a potent and selective histamine receptor H1 antagonist. Doxepin hydrochloride is also a potent CYP450 inhibitor and significantly inhibits CYP450 2C19 and 1A2[1][2].

HY-153671

4'-Methyl-β-naphthoflavone	Others	Infection
4'-Methyl-β-naphthoflavone is a metabolite of Naphthoflavones (benzoflavones) in fungal. Naphthoflavones are activators or inhibitors of CYP-450 .

HY-133091

7-Ethoxycoumarin 7-O-Ethylumbelliferone	Cytochrome P450	Others
7-Ethoxycoumarin is a substrate for cytochrome P450(CYP450) and has been used in the functional characterization of various CYPs[1].

HY-157170

CYP450-IN-1

Cytochrome P450 Cancer

CYP450-IN-1 (compound 2e) is a potent inhibitor of CYP450 .
HY-130550

(±)7(8)-EpDPA

Endogenous Metabolite Others

(±)7(8)-EpDPA is an epoxide derivative of docosahexaenoic acid (DHA) metabolized by CYP450 .
HY-145546

14(15)-EpETE

Cytochrome P450 Metabolic Disease

14(15)-EpETE is the epoxide of cytochrome P450 (CYP450) and is involved in the regulation of vascular tone and renal function .

CYP450-IN-1	Cytochrome P450	Cancer
CYP450-IN-1 (compound 2e) is a potent inhibitor of *CYP450* .

(±)7(8)-EpDPA	Endogenous Metabolite	Others
(±)7(8)-EpDPA is an epoxide derivative of docosahexaenoic acid (DHA) metabolized by CYP450 .

14(15)-EpETE	Cytochrome P450	Metabolic Disease
14(15)-EpETE is the epoxide of cytochrome P450 (CYP450) and is involved in the regulation of vascular tone and renal function .

HY-133091S

7-Ethoxycoumarin-d5	Cytochrome P450 Isotope-Labeled Compounds	Others
7-Ethoxycoumarin-d₅ is deuterium labeled 7-Ethoxycoumarin. 7-Ethoxycoumarin is a substrate for cytochrome P450(CYP450) and has been used in the functional characterization of various CYPs[1].

HY-130219

18-HETE	Endogenous Metabolite	Others
18-HETE (compound 3) is a monooxygenase metabolite of cytochrome P450 (CYP450).18- HETE consists of arachidonic acid bearing a hydroxy substituent at position 18 .

HY-B0725

Doxepin Hydrochloride 4 Publications Verification	Histamine Receptor Cytochrome P450	Neurological Disease Cancer
Doxepin hydrochloride is an orally active tricyclic antidepressant agent. Doxepin hydrochloride is a potent and selective histamine receptor H1 antagonist. Doxepin hydrochloride is also a potent *CYP450* inhibitor and significantly inhibits CYP450 2C19 and 1A2 . Doxepin inhibits reuptake of serotonin and norepinephrine as a tricyclic antidepressant . . Doxepin has therapeutic effects in atopic dermatitis，chronic urticarial，can improve cognitive processes， protect central nervous system . . Doxepin has also been proposed as a protective factor against oxidative stress . .

HY-109040

Quilseconazole VT-1129	Fungal Cytochrome P450	Infection
Quilseconazole (VT-1129) is a potent, orally active fungal Cyp51 (lanosterol 14-α-demethylase) inhibitor, binds tightly to cryptococcal CYP51, but weakly inhibits humans CYP450 enzymes .

HY-124527

HET0016 2 Publications Verification	Cytochrome P450	Cardiovascular Disease
HET0016 is a potent and selective 20-hydroxyeicosatetraenoic acid (20-HETE) synthase inhibitor, with IC₅₀ values of 17.7 nM, 12.1 nM and 20.6 nM for recombinant CYP4A1-, CYP4A2- and CYP4A3-catalyzed 20-HETE synthesis, respectively. HET0016 also is a selective *CYP450* inhibitor, which has been shown to inhibit angiogenesis and tumor growth .

HY-148907

CS640	Biochemical Assay Reagents	Cancer
CS640 is a selective inhibitor of calmodulin-dependent kinases. CS640 inhibits CaMK1D, CaMK1B, CaMK1A, CaMK1G, PIP5K1C, MEK5, RIPK4 and MLK3 with IC₅₀ values of 0.08, 0.03, 0.001, 0.001, 11.2, 0.025, 5.69 and 2.75 μM, respectively. CS640 also shows inhibitory effects to CYP450 2C9 and CYP450 2C19 with IC₅₀ values of 6 and 10 μM, respectively .

HY-115493

TIQ-15

CXCR Others

TIQ-15 is a potent CXCR4 antagonist with an IC₅₀ value of 6 nM for CXCR4 Ca ²⁺ flux. TIQ-15 inhibits CYP450 2D6 with an IC₅₀ value of 0.32 μM .

TIQ-15	CXCR	Others
TIQ-15 is a potent CXCR4 antagonist with an IC₅₀ value of 6 nM for CXCR4 Ca ²⁺ flux. TIQ-15 inhibits CYP450 2D6 with an IC₅₀ value of 0.32 μM .

HY-N1407

Polygalaxanthone III
Polygalaxanthone III is extracted from polygala tenuifolia wild, has inhibitory effect towards *CYP450* enzyme. Polygalaxanthone III inhibits chlorzoxazone 6-hydroxylation catalyzed by CYP2E1 with an IC₅₀ of 50.56 μM .

HY-B0725R

Doxepin Hydrochloride (Standard)	Histamine Receptor Cytochrome P450	Neurological Disease Cancer
Doxepin (Hydrochloride) (Standard) is the analytical standard of Doxepin (Hydrochloride). This product is intended for research and analytical applications. Doxepin hydrochloride is an orally active tricyclic antidepressant agent. Doxepin hydrochloride is a potent and selective histamine receptor H1 antagonist. Doxepin hydrochloride is also a potent *CYP450* inhibitor and significantly inhibits CYP450 2C19 and 1A2 . Doxepin inhibits reuptake of serotonin and norepinephrine as a tricyclic antidepressant . . Doxepin has therapeutic effects in atopic dermatitis，chronic urticarial，can improve cognitive processes， protect central nervous system . . Doxepin has also been proposed as a protective factor against oxidative stress . .

HY-113482

1β-Hydroxydeoxycholic acid 1β-OH-DCA	Endogenous Metabolite Cytochrome P450	Metabolic Disease
1β-Hydroxydeoxycholic acid (1β-OH-DCA), a secondary bile acid, is a CYP3A biomarker. Deoxycholic acid is specifically metabolized into 1β-Hydroxydeoxycholic acid by CYP3A4 and CYP3A7 using recombinant human CYP450 enzymes .

HY-12594

Paritaprevir 10+ Cited Publications ABT-450; Veruprevir	HCV Protease HCV SARS-CoV	Infection
Paritaprevir (ABT-450) is a potent, orally active and antiviral non-structural protein 3/4A (NS3/4A) protease inhibitor with EC₅₀s of 1 and 0.21 nM against HCV 1a and 1b, respectively. Paritaprevir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 1.31 μM. Paritaprevir is metabolized primarily by cytochrome P450 (CYP) 3A. The plasma concentration and half-life of Paritaprevir can be enhanced by Ritonavir (a CYP450 inhibitor) .

HY-12594A

Paritaprevir dihydrate ABT-450 dihydrate; Veruprevir dihydrate	HCV Protease HCV SARS-CoV	Infection
Paritaprevir (ABT-450) dihydrate is a potent, orally active and antiviral non-structural protein 3/4A (NS3/4A) protease inhibitor with EC₅₀s of 1 and 0.21 nM against HCV 1a and 1b, respectively. Paritaprevir dihydrate is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 1.31 μM. Paritaprevir dihydrate is metabolized primarily by cytochrome P450 (CYP) 3A. The plasma concentration and half-life of Paritaprevir dihydrate can be enhanced by Ritonavir (a CYP450 inhibitor) .

HY-B0653A

Levobupivacaine hydrochloride 2 Publications Verification (S)-(-)-Bupivacaine monohydrochloride	Sodium Channel Ferroptosis	Neurological Disease Cancer
Levobupivacaine hydrochloride ((S)-(-)-Bupivacaine monohydrochloride) is a long-acting amide local anaesthetic. Levobupivacaine hydrochloride exerts anaesthetic and analgesic effects through reversible blockade of neuronal sodium channel. Levobupivacaine hydrochloride can inhibit impulse transmission and conduction in cardiovascular and other tissues, possessing certain cardiac and CNS toxicity. Levobupivacaine hydrochloride is metabolized by hepatic cytochrome P450 (CYP450) enzymes in vivo. Levobupivacaine hydrochloride can also induce ferroptosis by miR-489-3p/SLC7A11 signaling in gastric cancer .

HY-B0653

Levobupivacaine (S)-(-)-Bupivacaine	Sodium Channel Ferroptosis	Neurological Disease Cancer
Levobupivacaine ((S)-(-)-Bupivacaine) is a long-acting amide local anaesthetic. Levobupivacaine exerts anaesthetic and analgesic effects through reversible blockade of neuronal sodium channel. Levobupivacaine can inhibit impulse transmission and conduction in cardiovascular and other tissues, possessing certain cardiac and CNS toxicity. Levobupivacaine is metabolized by hepatic cytochrome P450 (CYP450) enzymes in vivo. Levobupivacaine can also induce ferroptosis by miR-489-3p/SLC7A11 signaling in gastric cancer .

HY-N6023

Thermopsoside	Cytochrome P450	Others
Thermopsoside is a flavone derivative isolated from Aspalathus linearis. Thermopsoside exhibits inhibitory effects on CYP450 isozymes with IC₅₀ values of 6.0 μM, 9.5 μM, 12.0 μM, 32.0 μM, for CYP3A4, CYP2C19, CYP2D6 and CYP2C9, respectively .

HY-30152

Xanthotoxol 2 Publications Verification 8-Hydroxypsoralen	5-HT Receptor Reactive Oxygen Species Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Xanthotoxol (8-Hydroxypsoralen) It is a kind of fragrant bean substance, and it is a CYP450 inhibitor. Xanthotoxol has anti-inflammatory, anti-inflammatory, and 5-HT antagonistic and protective effects. Xanthotoxol inhibited CYP3A4 sum CYP1A2 IC50s separation 7.43 μM sum 27.82 μM. Xanthotoxol can pass through MAPK and NF-κB, inhibiting inflammation.

HY-W016034

Acetaminophen glucuronide sodium salt p-Acetamidophenyl β-D-glucuronide sodium salt; p-AAPG sodium salt	Others	Infection
Acetaminophen glucuronide is a safe and effective antipyretic analgesic. Acetaminophen glucuronide is potentially toxic to liver and kidney .

HY-G0004

**Acetaminophen metabolite 3-hydroxy-acetaminophen** 3-HydroxyAcetaminophen	Drug Metabolite	Inflammation/Immunology
3-hydroxy-acetaminophen is a metabolite of Acetaminophen, which is a pain medicine.

HY-10965

Rolofylline KW-3902	Adenosine Receptor	Neurological Disease
Rolofylline (KW-3902) is a potent, selective adenosine A1 receptor antagonist that is under development for the treatment of patients with acute congestive heart failure and renal impairment. Rolofylline is metabolized primarily to the pharmacologically active M1-trans and M1-cis metabolites by cytochrome P450 (CYP₄₅₀) . Rolofylline is alleviating the presynaptic dysfunction and restores neuronal activity as well as dendritic spine levels in vitro, is an interesting candidate to combat the hypometabolism and neuronal dysfunction associated with Tau-induced neurodegenerative diseases .

HY-66006S

4-Acetaminophen sulfate-d3

Isotope-Labeled Compounds Others

4-Acetaminophen sulfate-d₃ is the deuterium labeled 4-Acetaminophen sulfate[1].
HY-66006AS

4-Acetaminophen sulfate-d3 potassium

Isotope-Labeled Compounds Others

4-Acetaminophen sulfate-d₃ (potassium) is the deuterium labeled 4-Acetaminophen sulfate potassium[1].

*4-Acetaminophen* sulfate-d3**	Isotope-Labeled Compounds	Others
4-Acetaminophen sulfate-d₃ is the deuterium labeled 4-Acetaminophen sulfate[1].

*4-Acetaminophen* sulfate-d3 potassium**	Isotope-Labeled Compounds	Others
4-Acetaminophen sulfate-d₃ (potassium) is the deuterium labeled 4-Acetaminophen sulfate potassium[1].

HY-101016

17-ODYA
17-ODYA is a CYP450 ω-hydroxylase inhibitor. 17-ODYA is also a potent inhibitor (IC₅₀<100 nM) of the formation of 20-hydroxyeicosatetraenoic acid (20-HETE), epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids by rat renal cortical microsomes incubated with arachidonic acid. 17-ODYA completely attenuates the isoproterenol (ISO)-induced apoptosis, and necrosis in cultured cardiomyocytes . 17-ODYA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-66005S

Acetaminophen-d4	COX Histone Acetyltransferase Endogenous Metabolite	Inflammation/Immunology
Acetaminophen-d₄ is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent[1][2][3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[4].

HY-141736S

Acetaminophen dimer-d6

Isotope-Labeled Compounds Others

Acetaminophen dimer-d₆ is the deuterium labeled Acetaminophen dimer[1].
HY-143911S

Acetaminophen glucuronide-d3

Isotope-Labeled Compounds Others

Acetaminophen glucuronide-d₃ is the deuterium labeled Acetaminophen glucuronide[1].

Acetaminophen dimer-d6	Isotope-Labeled Compounds	Others
Acetaminophen dimer-d₆ is the deuterium labeled Acetaminophen dimer[1].

Acetaminophen glucuronide-d3	Isotope-Labeled Compounds	Others
Acetaminophen glucuronide-d₃ is the deuterium labeled Acetaminophen glucuronide[1].

HY-113083

Acetaminophen glucuronide APAP-glu	Drug Metabolite Endogenous Metabolite	Others
Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005) . Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .

HY-66005R

Acetaminophen (Standard) Maximum Cited Publications 35 Publications Verification Paracetamol (Standard); 4-Acetamidophenol (Standard); 4'-Hydroxyacetanilide (Standard)	COX Histone Acetyltransferase Endogenous Metabolite Bacterial Parasite	Inflammation/Immunology Cancer
Acetaminophen (Standard) is the analytical standard of Acetaminophen. This product is intended for research and analytical applications. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀ of 25.8 μM; is a widely used antipyretic and analgesic agent . Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .

HY-66005

*Acetaminophen* Maximum Cited Publications 35 Publications Verification Paracetamol; 4-Acetamidophenol; 4'-Hydroxyacetanilide	COX Histone Acetyltransferase Endogenous Metabolite Bacterial Parasite	Inflammation/Immunology Cancer
Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀ of 25.8 μM; is a widely used antipyretic and analgesic agent . Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .

HY-W016034S

Acetaminophen glucuronide-d3 sodium salt p-Acetamidophenyl β-D-glucuronide-d₃ sodium salt; p-AAPG-d₃ sodium salt	Isotope-Labeled Compounds	Others
Acetaminophen glucuronide-d₃ sodium salt is the deuterium labeled Acetaminophen glucuronide sodium salt.

HY-66005S2

Acetaminophen-d7 Paracetamol-d₇; 4-Acetamidophenol-d₇; 4'-Hydroxyacetanilide-d₇	COX Endogenous Metabolite Histone Acetyltransferase	Inflammation/Immunology
Acetaminophen-d₇ is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.

HY-66005S1

Acetaminophen-d3 Paracetamol-d₃; 4-Acetamidophenol-d₃; 4'-Hydroxyacetanilide-d₃	COX Histone Acetyltransferase Endogenous Metabolite	Inflammation/Immunology
Acetaminophen-d₃ is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent[1][2][3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[4].

HY-P3690

Ac-Leu-Leu-Norleucinol	Proteasome	Others
Ac-Leu-Leu-Norleucinol (ALLN) is a calpain inhibitor, can be used for research of Acetaminophen (HY-66005) induced acute liver damage, and lowers glutamic-oxalacetic transaminease (ALT) and glutamic-pyruvic transaminase (AST) .

HY-66005S4

Acetaminophen-13C2,15N Paracetamol-¹³C₂,¹⁵N; 4-Acetamidophenol-¹³C₂,¹⁵N; 4'-Hydroxyacetanilide-¹³C₂,¹⁵N	COX Bacterial Histone Acetyltransferase Parasite Endogenous Metabolite
Acetaminophen- ¹³C₂, ¹⁵N is the ¹³C and ¹⁵N labeled Acetaminophen[1]. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM;is a widely used antipyretic and analgesic agent[2][3][4]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[5].

HY-113381

2-Hydroxybutyric acid α-Hydroxybutyric acid	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
2-Hydroxybutyric acid (α-Hydroxybutyric acid ) is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite . 2-Hydroxybutyric acid is a potential biomarker for type 2 diabetes and preeclampsia . 2-Hydroxybutyric acid prevents the acetaminophen (AP)-induced liver injury .

HY-135325

4-Hydroxyacetophenone oxime	Drug Metabolite	Inflammation/Immunology
4-Hydroxyacetophenone oxime is an impurity of Acetaminophen (Paracetamol). Acetaminophen is a potent cyclooxygenase-2 (COX-2) and hepatic N-acetyltransferase 2 (NAT2) inhibitor, and used antipyretic and analgesic agent .

HY-66004

4-Acetamidophenyl acetate	Bacterial Parasite	Inflammation/Immunology Cancer
4-Acetamidophenyl acetate is an impurity of Acetaminophen (paracetamol). Acetaminophen, an analgesic agent, is a selective COX-2 inhibitor (IC₅₀=25.8 μM), and is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .

HY-124750

NecroX-7	TNF Receptor Interleukin Related Toll-like Receptor (TLR) Reactive Oxygen Species	Cardiovascular Disease Inflammation/Immunology
NecroX-7 is a potent free radical scavenger and a HMGB1 (high-mobility group box 1) inhibitor. NecroX-7 can be used as an antidote to acetaminophen toxicity. NecroX-7 exerts a protective effect by preventing the release of HMGB1 in ischemia/reperfusion injury. NecroX-7 inhibits the HMGB1-induced release of TNF and IL-6, as well as the expression of TLR-4 and receptor for advanced glycation end products. NecroX-7 can be used graft-versus-host disease (GVHD) research .

HY-66004R

4-Acetamidophenyl acetate (Standard)	Bacterial Parasite	Inflammation/Immunology Cancer
4-Acetamidophenyl acetate (Standard) is the analytical standard of 4-Acetamidophenyl acetate. This product is intended for research and analytical applications. 4-Acetamidophenyl acetate is an impurity of Acetaminophen (paracetamol). Acetaminophen, an analgesic agent, is a selective COX-2 inhibitor (IC₅₀=25.8 μM), and is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .

HY-156436

Anti-inflammatory agent 62	Others	Inflammation/Immunology
Anti-inflammatory agent 62 is an anti-inflammatory agent. Anti-inflammatory agent 62 alleviate Acetaminophen-induced hepatotoxicity in HepG2 by the regulation of inflammatory and oxidative stress pathways .

HY-N2109

Macranthoidin A	Others	Metabolic Disease
Macranthoidin A is an orally active saponin from Flos Lonicerae. Macranthoidin A possess protection effects on hepatic injury caused by Acetaminophen, Cd, and CCl4, and conspicuous depressant effects on swelling of ear croton oil .

HY-N4063

Hedragonic acid	FXR	Inflammation/Immunology
Hedragonic acid is an oleane-type triterpenoid compound, which can be isolated from the stems and roots of the southern snake vine. Hedragonic acid is a ligand and agonist for FXR. Hedragonic acid protected mice from liver damage caused by acetaminophen overdose and reduced liver inflammation .

HY-W017464

NAPQI	Drug Metabolite Endogenous Metabolite	Metabolic Disease
NAPQI is the toxic metabolite of Acetaminophen (HY-66005). NAPQI is also an inhibitor of enzymes in the vitamin K cycle. NAPQI is rapidly detoxified by glutathione (GSH), but in situations of GSH deficiency, excess NAPQI reacts with cysteine residues in proteins, causing cell death and toxicity in the liver .

HY-N12016

Fulvotomentoside B	Others	Metabolic Disease
Fulvotomentoside B is a saponin isolated from Lactobacillus flavus. Fulvotomentoside compounds can significantly reduce serum glutamate pyruvate transaminase (SGPT) and triacylglycerol (GT) levels in mice poisoned by CCl₄, d-galactosamine (d-gal) and acetaminophen, and significantly alleviate liver pathology. damage .

HY-131349

CCR4-351	CCR	Cancer
CCR4-351 is an orally active, potent and selective CCR4 antagonist. CCR4-351, featuring a novel piperidinyl-azetidine motif, has IC₅₀s of 22 nM and 50 nM in the calcium flux and CTX assay. CCR4-351 has antitumor activity .

Cat. No.	Product Name	Target	Research Area

HY-P4146

Survodutide BI 456906	GLP Receptor GCGR	Metabolic Disease
Survodutide (BI 456906) is a potent, selective glucagon receptor/GLP-1 receptor (GCGR/GLP-1R) dual agonist with EC₅₀s of 0.52 nM and 0.33 nM in CHO-K1 cells, respectively. Survodutide, a 29-amino-acid peptide, is a potent acylated peptide containing a C18 fatty acid. Survodutide has robust anti-obesity efficacy achieved by increasing energy expenditure and decreasing food intake .

HY-P4146A

Survodutide TFA BI 456906 TFA	GLP Receptor GCGR	Metabolic Disease
Survodutide (BI 456906) TFA is a potent, selective glucagon receptor/GLP-1 receptor (GCGR/GLP-1R) dual agonist with EC₅₀s of 0.52 nM and 0.33 nM in CHO-K1 cells, respectively. Survodutide TFA, a 29-amino-acid peptide, is a potent acylated peptide containing a C18 fatty acid. Survodutide TFA has robust anti-obesity efficacy achieved by increasing energy expenditure and decreasing food intake .