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Acetlycholine esterase Inhibitors

" in MedChemExpress (MCE) Product Catalog:

74

Inhibitors & Agonists

23

Fluorescent Dye

7

Biochemical Assay Reagents

4

Peptides

4

Natural
Products

24

Recombinant Proteins

1

Isotope-Labeled Compounds

7

Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P2879

    Endogenous Metabolite Metabolic Disease
    Cholesterol esterase, Pseudomonas is an enzyme that hydrolyzes cholesterol ester to cholesterol and free fatty acid in the intestinal lumen. Cholesterol synthesized in the acinar cells and is stored in zymogen granules. Cholesterol esterase is also known as bile salt-stimulated lipase and carboxy ester lipasea, acts function for acceleration of cholesterol absorption .
    Cholesterol <em>esterase</em>, Pseudomonas
  • HY-P2831

    CESs

    Endogenous Metabolite Metabolic Disease
    Esterase, pig liver (CESs), namely carboxylate hydrolases, are widely distributed in nature, commonly found in mammalian liver, and often used in biochemical research. Esterase catalyzes the hydrolysis of a variety of endogenous and exogenous substrates, including esters, thioesters, carbamates, and amides, hydrolyzing carboxylic acid esters to the corresponding alcohols and carboxylic acids .
    <em>Esterase</em>, pig liver
  • HY-E70115

    Others Others
    Feruloyl esterase plays a major role in the degradation of plant biomass. Feruloyl esterase catalyzes the cleavage and formation of ester bonds between plant cell wall polysaccharide and phenolic acid .
    Feruloyl <em>esterase</em>
  • HY-124258

    (-)-Valilactone

    Others Metabolic Disease
    Valilactone is a potent and effective inhibitor of esterase, produced by actinomycetes .
    Valilactone
  • HY-156984

    Others Neurological Disease
    Monometacrine is a cholesterol esterase inhibitor. Monometacrine has antidepressant effect .
    Monometacrine
  • HY-D2277

    Fluorescent Dye Others
    Fluorescein-CM2 is a fluorogenic molecule that can be used to rapidly screen esterase cut sites for protein-protein interaction-dependent (PPI-dependent) esterase activity in E. coli .
    Fluorescein-CM2
  • HY-D1678

    Fluorescent Dye Others
    5(6)-Carboxynaphthofluorescein diacetate is a fluorescent substrate for esterase assays that can be cleaved by intracellular esterases, producing red fluorescence to measure enzyme activity (Ex = 590 nm; Em = 645 nm) .
    5(6)-Carboxynaphthofluorescein diacetate
  • HY-E70343

    Endogenous Metabolite Others
    Human leukocyte esterase (unsonicated) is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
    Human leukocyte <em>esterase</em> (unsonicated)
  • HY-E70319

    Immobilized cephalosporin C or 7-ACA esterase

    Endogenous Metabolite Others
    AMK-EX (Immobilized cephalosporin C or 7-ACA esterase) is an immobilized enzyme, among which cephalosporin C C/7-ACA esterase is a type of enzyme that can hydrolyze the ester bond of cephalosporin C or 7-ACA. Immobilized enzyme is a technology that immobilizes enzymes on carriers, which can be easily separated and recovered, improving the stability, activity and reusability of enzymes .
    AMK-EX
  • HY-143252

    Cholinesterase (ChE) Metabolic Disease
    CEase-IN-1 (Compound A1H3) is a potent and selective cholesterol esterase (CEase) inhibitor with an IC50 of 0.36 μM. CEase-IN-1 can be used for the research of hypercholesterolemia .
    CEase-IN-1
  • HY-100085

    21-desDFZ

    Drug Metabolite Inflammation/Immunology
    21-Desacetyldeflazacort (21-desDFZ) is the active metabolite of Deflazacort (HY-13609). Deflazacort is an anti-inflammatory and immunosuppressant. Deflazacort is an inactive pro-drug which can be rapidly converted by esterases to the active metabolite 21-desacetyldeflazacort after oral administration .
    21-Desacetyldeflazacort
  • HY-145127

    C3-CA-DTZ

    Fluorescent Dye Neurological Disease
    ETZ (C3-CA-DTZ) is a promising luciferase substrate (prosubstrate) activatable in vivo by nonspecific esterase to enhance the brain delivery of the luciferin .
    ETZ
  • HY-W275616

    Others Others
    4-Methylumbelliferyl nonanoate is a fluorogenic substrate of esterases. 4-Methylumbelliferyl nonanoate can be hydrolyzed to 4-methylumbelliferone with bright blue fluorescence .
    4-Methylumbelliferyl nonanoate
  • HY-126561

    CMFDA

    Fluorescent Dye Others
    Green CMFDA is a cell-permeable fluorescent probe with Em of 514 nm and Ex of 485 nm and can be used as a cell tracer. Green CMFDA can be cleaved by non-specific esterases common in living cells, producing a fluorescent compound, fluorescein, visible using a fluorescent microscope .
    Green CMFDA
  • HY-131131

    Fluorescent Dye Others
    5-CFDA-AM is a cell-permeable esterase substrate that can be used as an active probe to measure enzyme activity and cell membrane integrity. 5-CFDA-AM is electroneutral and can enter the cell at a lower concentration than CFDA, where it is hydrolysed by intracellular esterases to produce carboxyfluorescein. Carboxyfluorescein contains an additional negative charge and can be better retained in the cell .
    5-CFDA-AM
  • HY-19651B

    TAK-147 fumarate

    Cholinesterase (ChE) Neurological Disease
    Zanapezil (TAK-147) fumarate is a potent, reversible and selective acetylcholine esterase (AChE) inhibitor. Zanapezil fumarate shows a potent and reversible inhibition of AChE activity in homogenates of the rat cerebral cortex (IC50=51.2 nM). Zanapezil fumarate shows a moderate inhibition of muscarinic M1 and M2 receptor binding with Ki values of 234 and 340 nM, respectively. Zanapezil fumarate can be used for the research of early stages of Alzheimer's disease (AD) .
    Zanapezil fumarate
  • HY-19651A

    TAK-147

    Cholinesterase (ChE) Neurological Disease
    Zanapezil (TAK-147) is a potent, reversible and selective acetylcholine esterase (AChE) inhibitor. Zanapezil shows a potent and reversible inhibition of AChE activity in homogenates of the rat cerebral cortex (IC50=51.2 nM). Zanapezil shows a moderate inhibition of muscarinic M1 and M2 receptor binding with Ki values of 234 and 340 nM, respectively. Zanapezil can be used for the research of early stages of Alzheimer's disease (AD) .
    Zanapezil
  • HY-19651

    TAK-147 free base

    Cholinesterase (ChE) Neurological Disease
    Zanapezil (TAK-147) free base is a potent, reversible and selective acetylcholine esterase (AChE) inhibitor. Zanapezil free base shows a potent and reversible inhibition of AChE activity in homogenates of the rat cerebral cortex (IC50=51.2 nM). Zanapezil free base shows a moderate inhibition of muscarinic M1 and M2 receptor binding with Ki values of 234 and 340 nM, respectively. Zanapezil free base can be used for the research of early stages of Alzheimer's disease (AD) .
    Zanapezil free base
  • HY-135036

    Others Others
    4-Methylumbelliferyl butyrate (4-MUB) is a coumarin-based fluorogenic substrate used for the identification of M. catarrhalis C4- esterase. 4-Methylumbelliferyl butyrate can converse to the blue-emissive 4-methylumbelliferone (4-MU; HY-N0187) .
    4-Methylumbelliferyl butyrate
  • HY-18522

    Phospholipase Metabolic Disease
    AA26-9 is a potent and broad spectrum serine hydrolase inhibitor. AA26-9 targets included serine peptidases, lipases, amidases, esterases, and thioesterases. AA26-9 shows inhibitory activity against approximately 1/3 of the 40+ serine hydrolases detected in immortalized T cell lines .
    AA26-9
  • HY-116016

    L-DOPA ethyl ester; Levodopa ethyl ester

    Dopamine Receptor Drug Metabolite Neurological Disease
    Etilevodopa (L-Dopa ethyl ester), an ethyl-ester proagent of Levodopa, is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Etilevodopa is used for the treatment of Parkinson disease (PD). Levodopa is the direct precursor of dopamine and is a suitable proagent as it facilitates CNS penetration and delivers dopamine .
    Etilevodopa
  • HY-116016A

    L-DOPA ethyl ester hydrochloride; Levodopa ethyl ester hydrochloride

    Dopamine Receptor Drug Metabolite Neurological Disease
    Etilevodopa (L-Dopa ethyl ester) hydrochloride, an ethyl-ester proagent of Levodopa, is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Etilevodopa hydrochloride is used for the treatment of Parkinson disease (PD). Levodopa is the direct precursor of dopamine and is a suitable proagent as it facilitates CNS penetration and delivers dopamine .
    Etilevodopa hydrochloride
  • HY-W411215

    Fluorescent Dye Others
    1,4-Diacetoxy-2,3-dicyanobenzene is a cell-permeable fluorescent probe. 1,4-Diacetoxy-2,3-dicyanobenzene crosses the cell membrane and is cleaved by cytosolic esterases to the fluorescent pH indicator 2,3-dicyano-hydroquinone (DCH). 1,4-Diacetoxy-2,3-dicyanobenzene can be used to monitor intracellular pH .
    1,4-Diacetoxy-2,3-dicyanobenzene
  • HY-E70100

    AXEs

    Others Others
    Acetylxylan esterases (AXEs) belongs to carbohydrate esterase family 4 (CE4). Acetylxylan esterases catalyzes the deacetylation of acetylated carbohydrates .
    Acetylxylan esterases
  • HY-52112

    5-bromo-4-chloroindoxyl acetate

    Fluorescent Dye Others
    BCDA (5-bromo-4-chloroindoxyl acetate) is a chromogenic substrate of esterase used to potently detect the activity of esterase .
    BCDA
  • HY-103610

    p-Anisil

    Others Cancer
    4,4'-Dimethoxybenzil is a human intestinal carboxyl esterase (hiCE) inhibitor with Ki of 70 nM.
    4,4'-Dimethoxybenzil
  • HY-19861

    Others Metabolic Disease
    SMP-028 is an inhibitor of neutral cholesterol esterase (CEase), with an IC50 of 1.01 μM.
    SMP-028
  • HY-B1323

    Dipivefrine hydrochloride

    Endogenous Metabolite Neurological Disease
    Dipivefrin hydrochloride (Dipivefrine hydrochloride) is an antiglaucoma proagent that is hydrolyzed to the active compound, epinephrine, by esterases in the cornea .
    Dipivefrin hydrochloride
  • HY-145235

    Cholinesterase (ChE) Others
    AChE-IN-4 shows the acetylcholine esterase inhibition (AChEI) with an IC50 value of 24.1 μM.
    AChE-IN-4
  • HY-D0719
    Fluorescein Diacetate
    3 Publications Verification

    3,6-Diacetoxyfluoran; Di-O-acetylfluorescein

    Biochemical Assay Reagents Others
    Fluorescein diacetate is a cell permeable esterase-substrate. Fluorescein diacetate can be used as a fluorogenic substrate for hGSTP1-1.
    Fluorescein Diacetate
  • HY-157797

    Others Cancer
    SN-38-CM2 is a split esterase, and shows >95% conversion to SN-38 within 5 min in vitro. SN-38-CM2 induces protein-protein interactions (PPI)-dependent esterase to mediate cell death in MDA-MB-231 cells .
    SN-38-CM2
  • HY-102054

    FAAH Cardiovascular Disease
    Acetylhydrolase-IN-1 is a 1-Alkyl-2-acetylglycerophosphocholine esterase (Alkylacetyl-GPC: acetylhydrolase) inhibtor.
    Acetylhydrolase-IN-1
  • HY-P6079

    Biochemical Assay Reagents Neurological Disease
    Ac-IHIHIYI-NH2 is a fibrous heptapeptide that forms fibril-like structures with even higher esterase activity .
    Ac-IHIHIYI-NH2
  • HY-P6079A

    Biochemical Assay Reagents Others
    Ac-IHIHIYI-NH2 TFA is an amyloid self-assembling peptide variant that can be used as a bioactive nanomaterial with esterase activity .
    Ac-IHIHIYI-NH2 TFA
  • HY-114336
    Enocyanin
    1 Publications Verification

    Phosphatase Inflammation/Immunology
    Enocyanin is an anthocyanin extracted from grapes. Enocyanin shows inhibitory effect on the leucine aminopeptidase, acid phosphatase, γ-glutamyl transpeptidase and esterase activity .
    Enocyanin
  • HY-D0158

    Biochemical Assay Reagents Others
    ZnAF-2DAavailable for testing Zn(2+)fluorescence, as Zn(2+)Probe (after esterase hydrolysis).
    ZnAF-2 DA
  • HY-B1323S

    Dipivefrine-d6 hydrochloride

    Isotope-Labeled Compounds Endogenous Metabolite Neurological Disease
    Dipivefrin-d6 (hydrochloride) is deuterium labeled Dipivefrin (hydrochloride). Dipivefrin hydrochloride (Dipivefrine hydrochloride) is an antiglaucoma proagent that is hydrolyzed to the active compound, epinephrine, by esterases in the cornea[1][2].
    Dipivefrin-d6 hydrochloride
  • HY-P2895

    Clostridiopeptidase B

    Endogenous Metabolite Others
    Clostripain (Clostridiopeptidase B) is a proteolytic enzyme isolated from Clostridium histolyticum with esterase, amidase and protease activities and is a highly specific carboxypeptide targeting arginine key protease .
    Clostripain
  • HY-D1758

    Fluorescent Dye Others
    Fura-5F AM is a membrane-permeant fluorescent calcium indicator. Upon entering the cell, this probe is hydrolyzed by cytosilic esterases and trapped as the active chelator.
    Fura-5F AM
  • HY-D1759

    Fluorescent Dye Others
    Fura-4F AM is a cell-permeant fluorescent calcium indicator. Upon entering the cell, this probe is hydrolyzed by cytosilic esterases and trapped as the active chelator.
    Fura-4F AM
  • HY-W099563

    Biochemical Assay Reagents Others
    4-Nitrophenyl stearate, which is an ester formed by the condensation of stearic acid and 4-nitrophenol, is commonly used as a substrate for enzymatic assays, where the hydrolysis of ester bonds by esterase and lipase can be measured by absorbance or ratio In addition, 4-Nitrophenyl stearate has been used as a model compound to study the enzymatic activity and selectivity of lipases and esterases from various sources. The long hydrophobic tail of the molecule makes it suitable for use in lipophilic Good solubility in the environment makes it a useful probe for studying lipid metabolism.
    4-Nitrophenyl stearate
  • HY-13538
    Gemcitabine elaidate
    2 Publications Verification

    CP-4126; CO-101; Gemcitabine 5'-elaidate

    Nucleoside Antimetabolite/Analog Autophagy Apoptosis Cancer
    Gemcitabine elaidate (CP-4126) is lipophilic pro-agent of Gemcitabine. Gemcitabine elaidate is converted to Gemcitabine by esterases in order to be phosphorylated. Gemcitabine elaidate exhibits anti-tumor activity .
    Gemcitabine elaidate
  • HY-13538A
    Gemcitabine elaidate hydrochloride
    2 Publications Verification

    CP-4126 hydrochloride; CO-101 hydrochloride; Gemcitabine 5'-elaidate hydrochloride

    Nucleoside Antimetabolite/Analog Autophagy Apoptosis Cancer
    Gemcitabine elaidate (CP-4126) hydrochloride is lipophilic pro-agent of Gemcitabine. Gemcitabine elaidate hydrochloride is converted to Gemcitabine by esterases in order to be phosphorylated. Gemcitabine elaidate hydrochloride exhibits anti-tumor activity .
    Gemcitabine elaidate hydrochloride
  • HY-D1176

    Fluorescent Dye Others
    Calcium Green 1AM is a cell-permeant fluorescent calcium indicator (Excitation 506 nm; Emission 531 nm). Calcium Green 1AM is converted to the fluorescent calcium indicator by intracellular esterases .
    Calcium Green 1AM
  • HY-B0305A

    HOE 760

    Histamine Receptor Metabolic Disease Inflammation/Immunology Cancer
    Roxatidine Acetate Hydrochloride is a potent, selective, competitive and orally active histamine H2-receptor antagonist. Roxatidine Acetate Hydrochloride has antisecretory potency against gastric acid secretion. Roxatidine Acetate Hydrochloride can also suppress inflammatory responses and can be used for gastric and duodenal ulcers research. Roxatidine Acetate Hydrochloride has antitumor activity .
    Roxatidine Acetate Hydrochloride
  • HY-114879
    DDAO
    1 Publications Verification

    Fluorescent Dye Cancer
    DDAO is a promising near-infrared (NIR) red fluorescent probewith tunable excitation wavelength (600-650nm) and longemission wavelength(λem=656nm). DDAO can de desiged for detection of the activities of different enzymes such asβ-galactosidase,sulfatase, proteinphosphatase2A,carboxylesterase 2, humanalbumin andesterases .
    DDAO
  • HY-108751

    Others Neurological Disease
    Aripiprazole lauroxil, an N-acyloxymethyl proagent of aripiprazole, is a Long-acting injectable (LAI) typical antipsychotic for schizophrenia. Aripiprazole lauroxil is cleaved by body’s enzyme esterase to N-hydroxymethyl aripiprazole (plus lauric acid) and then to aripiprazole (plus formaldehyde), no toxicity.
    Aripiprazole Lauroxil
  • HY-W399193

    Prostaglandin F2α 1,9-lactone

    Others Metabolic Disease
    PGF2α 1,9-lactone (Prostaglandin F2α 1,9-lactone) is a prostaglandin lactone. PGF2α 1,9-lactone shows resistant to hydrolysis by plasma esterases .
    PGF2α 1,9-lactone
  • HY-D0717
    DAF-FM DA
    5+ Cited Publications

    Diaminofluorescein-FM diacetate

    Fluorescent Dye Others
    DAF-FM DA (Diaminofluorescein-FM diacetate) is a fluorescent probe for the detection and bioimaging of nitric oxide (NO). DAF-FM DA spontaneously crosses the plasma membrane and is subsequently cleaved by esterases to generate intracellular DAF-FM (Ex/Em=495/515 nm) .
    DAF-FM DA
  • HY-106409
    Tefinostat
    1 Publications Verification

    CHR-2845

    HDAC Apoptosis Cancer
    Tefinostat (CHR-2845) is a monocyte/macrophage targeted histone deacetylase (HDAC) inhibitor. Tefinostat can be cleaved into active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1). Tefinostat can be used for the research of leukaemias .
    Tefinostat

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