Search Result

Pathways Recommended:	TGF-beta/Smad

Results for "

Activated Integrinalpha 5 beta 1 Inhibitors

" in MCE Product Catalog:

By Targets:	11β-HSD (22) Amyloid-β (172) Beta-secretase (32) Dopamine β-hydroxylase (10) TGF-beta/Smad (34) TGF-β Receptor (51) β-catenin (59) 5-HT Receptor (29) Ack1 (1) Acyltransferase (4) ADC Cytotoxin (5) ADC Linker (10) Adenosine Deaminase (1) Adenosine Kinase (1) Adenosine Receptor (10) Adenylate Cyclase (8) Adiponectin Receptor (1) Adrenergic Receptor (278) Akt (47) Aldehyde Dehydrogenase (ALDH) (4) Aminoacyl-tRNA Synthetase (1) Aminopeptidase (2) AMPK (76) Amylin Receptor (3) Anaplastic lymphoma kinase (ALK) (3) Androgen Receptor (6) Angiotensin Receptor (6) Angiotensin-converting Enzyme (ACE) (7) Antibiotic (149) Antifolate (2) AP-1 (4) APC (2) Apelin Receptor (APJ) (14) Apoptosis (616) Arenavirus (1) Arginase (1) Aromatase (1) Arp2/3 Complex (4) Aryl Hydrocarbon Receptor (14) ATF6 (2) ATM/ATR (4) ATP Citrate Lyase (1) Aurora Kinase (3) Autophagy (371) Bacterial (286) Bcl-2 Family (36) Bcr-Abl (12) BCRP (1) Beclin1 (1) Bombesin Receptor (1) Btk (2) c-Fms (7) c-Kit (33) c-Met/HGFR (11) c-Myc (4) Calcium Channel (48) Calmodulin (5) CaMK (3) Cannabinoid Receptor (21) Carbonic Anhydrase (4) Casein Kinase (16) Caspase (52) CaSR (7) Cathepsin (5) CCR (9) CD73 (2) CDK (43) CFTR (3) CGRP Receptor (7) Checkpoint Kinase (Chk) (2) Chloride Channel (18) Cholinesterase (ChE) (44) CMV (1) Complement System (12) COMT (3) COX (54) CRAC Channel (2) CRFR (11) CRISPR/Cas9 (5) CTLA-4 (2) CXCR (12) Cyclic GMP-AMP Synthase (1) Cytochrome P450 (23) Deubiquitinase (1) Dihydroorotate Dehydrogenase (4) Dipeptidyl Peptidase (7) Discoidin Domain Receptor (2) DNA Alkylator/Crosslinker (10) DNA Methyltransferase (3) DNA Stain (2) DNA-PK (13) DNA/RNA Synthesis (46) Dopamine Receptor (18) Dopamine Transporter (2) Drug Metabolite (37) Drug-Linker Conjugates for ADC (5) DYRK (7) E1/E2/E3 Enzyme (22) EAAT2 (2) Early 2 Factor (E2F) (1) EBI2/GPR183 (1) EBV (1) EGFR (24) Endogenous Metabolite (422) Enterovirus (7) Ephrin Receptor (4) Epigenetic Reader Domain (9) Epoxide Hydrolase (4) ERK (52) Estrogen Receptor/ERR (94) Eukaryotic Initiation Factor (eIF) (5) FAAH (1) Factor Xa (5) FAK (2) Farnesyl Transferase (1) Fatty Acid Synthase (FASN) (6) Ferroportin (1) Ferroptosis (40) FGFR (34) Filovirus (1) FKBP (4) FLAP (9) FLT3 (18) Formyl Peptide Receptor (FPR) (8) Free Fatty Acid Receptor (6) Fungal (42) FXR (19) G protein-coupled Bile Acid Receptor 1 (13) G Protein-coupled Receptor Kinase (GRK) (2) G-quadruplex (1) GABA Receptor (55) Galectin (1) Gap Junction Protein (1) GCGR (7) Glucocorticoid Receptor (20) Glucokinase (18) Glucosidase (21) GLUT (4) Glutathione Peroxidase (2) GlyT (1) GnRH Receptor (3) GPR109A (1) GPR119 (3) GPR35 (3) GPR55 (1) GPR68 (1) GPR84 (2) GSK-3 (83) Guanylate Cyclase (22) Gutathione S-transferase (2) HBV (6) HCN Channel (6) HCV (11) HDAC (35) Hedgehog (3) HIF/HIF Prolyl-Hydroxylase (18) Hippo (MST) (1) Histamine Receptor (11) Histone Acetyltransferase (11) Histone Demethylase (6) Histone Methyltransferase (4) HIV (50) HIV Protease (4) HMG-CoA Reductase (HMGCR) (3) HPV (1) HSP (25) HSV (19) IAP (5) IFNAR (11) iGluR (27) IKK (35) Imidazoline Receptor (4) Indoleamine 2,3-Dioxygenase (IDO) (1) Influenza Virus (17) Insulin Receptor (7) Integrin (78) Interleukin Related (66) IRAK (5) IRE1 (8) JAK (14) JNK (24) Keap1-Nrf2 (62) Kinesin (1) Lactate Dehydrogenase (1) Leukotriene Receptor (10) Ligands for E3 Ligase (2) Ligands for Target Protein for PROTAC (3) Lipoxygenase (8) LPL Receptor (14) LRRK2 (1) LXR (24) mAChR (31) MAGL (8) MAP3K (1) MAP4K (4) MAPKAPK2 (MK2) (4) Mas-related G-protein-coupled Receptor (MRGPR) (2) MCHR1 (GPR24) (3) MDM-2/p53 (30) MEK (14) Melanocortin Receptor (10) Melatonin Receptor (4) mGluR (12) MicroRNA (5) Microtubule/Tubulin (42) Mineralocorticoid Receptor (3) Mitochondrial Metabolism (17) Mitophagy (57) Mixed Lineage Kinase (3) MMP (23) Monoamine Oxidase (19) Monoamine Transporter (1) mTOR (67) MyD88 (2) Myosin (4) Na+/Ca2+ Exchanger (6) Na+/K+ ATPase (14) nAChR (74) NADPH Oxidase (4) NAMPT (2) Necroptosis (2) NEDD8-activating Enzyme (6) Neprilysin (1) Neurokinin Receptor (2) Neuropeptide Y Receptor (6) Neurotensin Receptor (1) NF-κB (167) NO Synthase (20) NOD-like Receptor (NLR) (36) Notch (18) Nuclear Factor of activated T Cells (NFAT) (11) Nucleoside Antimetabolite/Analog (27) Oct3/4 (4) Opioid Receptor (29) Orexin Receptor (OX Receptor) (1) Orthopoxvirus (8) Oxytocin Receptor (3) P-glycoprotein (5) P2X Receptor (8) P2Y Receptor (3) p38 MAPK (72) PAI-1 (20) PAK (12) Parasite (66) PARP (23) PD-1/PD-L1 (14) PDGFR (77) PDK-1 (6) PERK (5) PGC-1α (3) PGE synthase (6) Phosphatase (41) Phosphodiesterase (PDE) (33) Phospholipase (16) PI3K (110) PI4K (9) Piezo Channel (4) Pim (2) PKA (22) PKC (64) Platelet-activating Factor Receptor (PAFR) (16) Polo-like Kinase (PLK) (1) Porcupine (1) Potassium Channel (124) PPAR (92) Progesterone Receptor (2) Prolyl Endopeptidase (PREP) (4) Prostaglandin Receptor (9) PROTAC Linkers (12) PROTACs (6) Protease Activated Receptor (PAR) (45) Proteasome (30) Protein Arginine Deiminase (1) Proton Pump (6) PTEN (3) Pyroptosis (2) Pyruvate Kinase (15) RAD51 (1) Raf (13) RANKL/RANK (2) RAR/RXR (36) Ras (23) Reactive Oxygen Species (82) Renin (3) RET (8) REV-ERB (4) Reverse Transcriptase (11) Ribosomal S6 Kinase (RSK) (6) RIP kinase (8) ROCK (1) ROR (7) ROS Kinase (5) RSV (1) Salt-inducible Kinase (SIK) (1) SARS-CoV (29) Ser/Thr Protease (19) Serotonin Transporter (1) SGK (3) SHP2 (7) Sigma Receptor (1) Sirtuin (29) Smo (8) Sodium Channel (29) Somatostatin Receptor (1) SphK (6) Src (21) STAT (33) Stearoyl-CoA Desaturase (SCD) (1) STING (24) Survivin (2) Syk (3) TAM Receptor (4) Tau Protein (3) Telomerase (4) Thrombin (5) Thrombopoietin Receptor (4) Thyroid Hormone Receptor (16) TNF Receptor (47) Toll-like Receptor (TLR) (23) TOPK (3) Topoisomerase (16) Trace Amine-associated Receptor (TAAR) (3) Trk Receptor (7) TRP Channel (49) TSH Receptor (3) Tyrosinase (15) ULK (5) VD/VDR (14) VEGFR (77) Virus Protease (10) Wnt (67) Xanthine Oxidase (1) YAP (5) γ-secretase (28)
By Research Areas:	Cancer (1883) Cardiovascular Disease (519) Endocrinology (321) Infection (479) Inflammation/Immunology (1045) Metabolic Disease (681) Neurological Disease (989)

By Targets:

11β-HSD (22)

Amyloid-β (172)

Beta-secretase (32)

Dopamine β-hydroxylase (10)

TGF-beta/Smad (34)

TGF-β Receptor (51)

β-catenin (59)

5-HT Receptor (29)

Ack1 (1)

Acyltransferase (4)

ADC Cytotoxin (5)

ADC Linker (10)

Adenosine Deaminase (1)

Adenosine Kinase (1)

Adenosine Receptor (10)

Adenylate Cyclase (8)

Adiponectin Receptor (1)

Adrenergic Receptor (278)

Akt (47)

Aldehyde Dehydrogenase (ALDH) (4)

Aminoacyl-tRNA Synthetase (1)

Aminopeptidase (2)

AMPK (76)

Amylin Receptor (3)

Anaplastic lymphoma kinase (ALK) (3)

Androgen Receptor (6)

Angiotensin Receptor (6)

Angiotensin-converting Enzyme (ACE) (7)

Antibiotic (149)

Antifolate (2)

AP-1 (4)

APC (2)

Apelin Receptor (APJ) (14)

Apoptosis (616)

Arenavirus (1)

Arginase (1)

Aromatase (1)

Arp2/3 Complex (4)

Aryl Hydrocarbon Receptor (14)

ATF6 (2)

ATM/ATR (4)

ATP Citrate Lyase (1)

Aurora Kinase (3)

Autophagy (371)

Bacterial (286)

Bcl-2 Family (36)

Bcr-Abl (12)

BCRP (1)

Beclin1 (1)

Bombesin Receptor (1)

Btk (2)

c-Fms (7)

c-Kit (33)

c-Met/HGFR (11)

c-Myc (4)

Calcium Channel (48)

Calmodulin (5)

CaMK (3)

Cannabinoid Receptor (21)

Carbonic Anhydrase (4)

Casein Kinase (16)

Caspase (52)

CaSR (7)

Cathepsin (5)

CCR (9)

CD73 (2)

CDK (43)

CFTR (3)

CGRP Receptor (7)

Checkpoint Kinase (Chk) (2)

Chloride Channel (18)

Cholinesterase (ChE) (44)

CMV (1)

Complement System (12)

COMT (3)

COX (54)

CRAC Channel (2)

CRFR (11)

CRISPR/Cas9 (5)

CTLA-4 (2)

CXCR (12)

Cyclic GMP-AMP Synthase (1)

Cytochrome P450 (23)

Deubiquitinase (1)

Dihydroorotate Dehydrogenase (4)

Dipeptidyl Peptidase (7)

Discoidin Domain Receptor (2)

DNA Alkylator/Crosslinker (10)

DNA Methyltransferase (3)

DNA Stain (2)

DNA-PK (13)

DNA/RNA Synthesis (46)

Dopamine Receptor (18)

Dopamine Transporter (2)

Drug Metabolite (37)

Drug-Linker Conjugates for ADC (5)

DYRK (7)

E1/E2/E3 Enzyme (22)

EAAT2 (2)

Early 2 Factor (E2F) (1)

EBI2/GPR183 (1)

EBV (1)

EGFR (24)

Endogenous Metabolite (422)

Enterovirus (7)

Ephrin Receptor (4)

Epigenetic Reader Domain (9)

Epoxide Hydrolase (4)

ERK (52)

Estrogen Receptor/ERR (94)

Eukaryotic Initiation Factor (eIF) (5)

FAAH (1)

Factor Xa (5)

FAK (2)

Farnesyl Transferase (1)

Fatty Acid Synthase (FASN) (6)

Ferroportin (1)

Ferroptosis (40)

FGFR (34)

Filovirus (1)

FKBP (4)

FLAP (9)

FLT3 (18)

Formyl Peptide Receptor (FPR) (8)

Free Fatty Acid Receptor (6)

Fungal (42)

FXR (19)

G protein-coupled Bile Acid Receptor 1 (13)

G Protein-coupled Receptor Kinase (GRK) (2)

G-quadruplex (1)

GABA Receptor (55)

Galectin (1)

Gap Junction Protein (1)

GCGR (7)

Glucocorticoid Receptor (20)

Glucokinase (18)

Glucosidase (21)

GLUT (4)

Glutathione Peroxidase (2)

GlyT (1)

GnRH Receptor (3)

GPR109A (1)

GPR119 (3)

GPR35 (3)

GPR55 (1)

GPR68 (1)

GPR84 (2)

GSK-3 (83)

Guanylate Cyclase (22)

Gutathione S-transferase (2)

HBV (6)

HCN Channel (6)

HCV (11)

HDAC (35)

Hedgehog (3)

HIF/HIF Prolyl-Hydroxylase (18)

Hippo (MST) (1)

Histamine Receptor (11)

Histone Acetyltransferase (11)

Histone Demethylase (6)

Histone Methyltransferase (4)

HIV (50)

HIV Protease (4)

HMG-CoA Reductase (HMGCR) (3)

HPV (1)

HSP (25)

HSV (19)

IAP (5)

IFNAR (11)

iGluR (27)

IKK (35)

Imidazoline Receptor (4)

Indoleamine 2,3-Dioxygenase (IDO) (1)

Influenza Virus (17)

Insulin Receptor (7)

Integrin (78)

Interleukin Related (66)

IRAK (5)

IRE1 (8)

JAK (14)

JNK (24)

Keap1-Nrf2 (62)

Kinesin (1)

Lactate Dehydrogenase (1)

Leukotriene Receptor (10)

Ligands for E3 Ligase (2)

Ligands for Target Protein for PROTAC (3)

Lipoxygenase (8)

LPL Receptor (14)

LRRK2 (1)

LXR (24)

mAChR (31)

MAGL (8)

MAP3K (1)

MAP4K (4)

MAPKAPK2 (MK2) (4)

Mas-related G-protein-coupled Receptor (MRGPR) (2)

MCHR1 (GPR24) (3)

MDM-2/p53 (30)

MEK (14)

Melanocortin Receptor (10)

Melatonin Receptor (4)

mGluR (12)

MicroRNA (5)

Microtubule/Tubulin (42)

Mineralocorticoid Receptor (3)

Mitochondrial Metabolism (17)

Mitophagy (57)

Mixed Lineage Kinase (3)

MMP (23)

Monoamine Oxidase (19)

Monoamine Transporter (1)

mTOR (67)

MyD88 (2)

Myosin (4)

Na+/Ca2+ Exchanger (6)

Na+/K+ ATPase (14)

nAChR (74)

NADPH Oxidase (4)

NAMPT (2)

Necroptosis (2)

NEDD8-activating Enzyme (6)

Neprilysin (1)

Neurokinin Receptor (2)

Neuropeptide Y Receptor (6)

Neurotensin Receptor (1)

NF-κB (167)

NO Synthase (20)

NOD-like Receptor (NLR) (36)

Notch (18)

Nuclear Factor of activated T Cells (NFAT) (11)

Nucleoside Antimetabolite/Analog (27)

Oct3/4 (4)

Opioid Receptor (29)

Orexin Receptor (OX Receptor) (1)

Orthopoxvirus (8)

Oxytocin Receptor (3)

P-glycoprotein (5)

P2X Receptor (8)

P2Y Receptor (3)

p38 MAPK (72)

PAI-1 (20)

PAK (12)

Parasite (66)

PARP (23)

PD-1/PD-L1 (14)

PDGFR (77)

PDK-1 (6)

PERK (5)

PGC-1α (3)

PGE synthase (6)

Phosphatase (41)

Phosphodiesterase (PDE) (33)

Phospholipase (16)

PI3K (110)

PI4K (9)

Piezo Channel (4)

Pim (2)

PKA (22)

PKC (64)

Platelet-activating Factor Receptor (PAFR) (16)

Polo-like Kinase (PLK) (1)

Porcupine (1)

Potassium Channel (124)

PPAR (92)

Progesterone Receptor (2)

Prolyl Endopeptidase (PREP) (4)

Prostaglandin Receptor (9)

PROTAC Linkers (12)

PROTACs (6)

Protease Activated Receptor (PAR) (45)

Proteasome (30)

Protein Arginine Deiminase (1)

Proton Pump (6)

PTEN (3)

Pyroptosis (2)

Pyruvate Kinase (15)

RAD51 (1)

Raf (13)

RANKL/RANK (2)

RAR/RXR (36)

Ras (23)

Reactive Oxygen Species (82)

Renin (3)

RET (8)

REV-ERB (4)

Reverse Transcriptase (11)

Ribosomal S6 Kinase (RSK) (6)

RIP kinase (8)

ROCK (1)

ROR (7)

ROS Kinase (5)

RSV (1)

Salt-inducible Kinase (SIK) (1)

SARS-CoV (29)

Ser/Thr Protease (19)

Serotonin Transporter (1)

SGK (3)

SHP2 (7)

Sigma Receptor (1)

Sirtuin (29)

Smo (8)

Sodium Channel (29)

Somatostatin Receptor (1)

SphK (6)

Src (21)

STAT (33)

Stearoyl-CoA Desaturase (SCD) (1)

STING (24)

Survivin (2)

Syk (3)

TAM Receptor (4)

Tau Protein (3)

Telomerase (4)

Thrombin (5)

Thrombopoietin Receptor (4)

Thyroid Hormone Receptor (16)

TNF Receptor (47)

Toll-like Receptor (TLR) (23)

TOPK (3)

Topoisomerase (16)

Trace Amine-associated Receptor (TAAR) (3)

Trk Receptor (7)

TRP Channel (49)

TSH Receptor (3)

Tyrosinase (15)

ULK (5)

VD/VDR (14)

VEGFR (77)

Virus Protease (10)

Wnt (67)

Xanthine Oxidase (1)

YAP (5)

γ-secretase (28)

By Research Areas:

Cancer (1883)

Cardiovascular Disease (519)

Endocrinology (321)

Infection (479)

Inflammation/Immunology (1045)

Metabolic Disease (681)

Neurological Disease (989)

4845

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

498

Peptides

Inhibitory Antibodies

915

Natural
Products

695

Recombinant Proteins

608

Isotope-Labeled Compounds

Targets Recommended: Amyloid-β TGF-β Receptor Beta-secretase TGF-beta/Smad β-catenin 11β-HSD Dopamine β-hydroxylase

Cat. No.	Product Name	Target	Research Areas

HY-108790

*Peginterferon beta-1a* Peginterferon β-1a	Apoptosis	Cancer Neurological Disease
Peginterferon beta-1a (Peginterferon β-1a) is the first pegylated interferon beta-1a molecule. Peginterferon beta-1a induces cancer cells apoptosis and shows anti-tumor activities in nude mice models. Peginterferon beta-1a can be used for the research of cancer and multiple sclerosis (RMS).

HY-P2294

pm26TGF-β1 peptide	TGF-β Receptor	Inflammation/Immunology
pm26TGF-β1 peptide is a peptide that mimics a portion of the human TGF-β1 molecule. pm26TGF-β1 peptide shows high affinity for the TGF-β1 receptor. pm26TGF-β1 peptide displays potent anti-inflammatory properties and does not exhibit neutrophils’ chemoattraction.

HY-P2294A

pm26TGF-β1 peptide TFA	TGF-β Receptor	Inflammation/Immunology
pm26TGF-β1 TFA peptide is a peptide that mimics a portion of the human TGF-β1 molecule. pm26TGF-β1 peptide TFA shows high affinity for the TGF-β1 receptor. pm26TGF-β1 peptide TFA displays potent anti-inflammatory properties and does not exhibit neutrophils’ chemoattraction.

HY-139702

*α5β1* integrin agonist-1**	Integrin	Cancer
α5β1 integrin agonist-1, acting as *α5β1* integrin** agonist, is able to selectively deliver 5-FU into tumor cells, successfully leading to cancer cell death.

HY-P1868

α2β1 Integrin Ligand Peptide	Integrin	Infection
α2β1 Integrin Ligand Peptide interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellular signals into cells. It is a potential antagonist of collagen receptors.

HY-P1868A

α2β1 Integrin Ligand Peptide TFA	Integrin	Others
α2β1 Integrin Ligand Peptide TFA interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellular signals into cells. It is a potential antagonist of collagen receptors.

HY-N10636

D-lactosyl-β-1,1′ N-stearoyl-D-erythro-sphingosine
Others Others

D-lactosyl-β-1,1′ N-stearoyl-D-erythro-sphingosine is a neutral glycolipid.

*D-lactosyl-β-1,1′ N-stearoyl-D-erythro-sphingosine*	Others	Others
D-lactosyl-β-1,1′ N-stearoyl-D-erythro-sphingosine is a neutral glycolipid.

HY-N10634

*D-Glucosyl-β-1,1′-N-palmitoylsphingosine* C16 Glucosyl(β) Ceramide (d18:1/16:0)	Others	Inflammation/Immunology
D-Glucosyl-β-1,1′-N-palmitoylsphingosine (C16 Glucosyl(β) Ceramide (d18:1/16:0)) is an endogenous Mincle ligand possessing immunostimulatory activity.

HY-112956

*Drotrecogin alfa (activated)*	Others	Inflammation/Immunology
Drotrecogin alfa activated (DrotAA) is recombinant human activated protein C (APC). Drotrecogin alfa activated prevents smoke-induced increases in pulmonary microvascular permeability and proinflammatory cytokine IL-1β in rats. Drotrecogin alfa activated inhibits coagulation and inflammation and promotes fibrinolysis. Drotrecogin alfa activated can be used for severe sepsis reaearch.

HY-N2468

Xylobiose 1,4-β-D-Xylobiose; 1,4-D-Xylobiose	Others	Others
Xylobiose (1,4-β-D-Xylobiose; 1,4-D-Xylobiose) is a disaccharide of xylose monomers with a β-1, 4 bond between monomers.

HY-A0275

Amezinium methylsulfate Amezinium metilsulfate; Lu-1631	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Amezinium metilsulfate has multiple mechanisms, including stimulation of alpha and beta-1 receptors and inhibition ofnoradrenaline and tyramine uptake.

HY-B1154

Penbutolol sulfate (-)-Terbuclomine	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Penbutolol sulfate is able to bind to both beta-1 adrenergic receptors and beta-2 adrenergic receptors (the two subtypes), thus making it a non-selective β blocker.

HY-N9439

6-O-β-D-Galactopyranosyl-D-galactose	Others	Others
6-O-β-D-Galactopyranosyl-D-galactose, a disaccharide, is a part of the polysaccharide main chain with β-(1→6)-glycoside bonds with a side chain bonded to the main one by the β-(1→3) bond.

HY-N1548

Prunasin
DNA/RNA Synthesis Cancer

Prunasin is a inhibitor of DNA Polymerase β.

Prunasin	DNA/RNA Synthesis	Cancer
Prunasin is a inhibitor of DNA Polymerase β.

HY-129453

BOP sodium	Integrin	Inflammation/Immunology
BOP sodium is a potent and selective dual α9β1/α4β1 integrin inhibitor with K_d values in the picomolar range. BOP sodium shows the rapid and preferential mobilization of hematopoietic stem cell (HSC) and progenitors. BOP sodium has little inhibitory activity on α4β7, α1β1, α2β1, and α5β1, αIIBβ3 integrins.

HY-B0381A

Betaxolol hydrochloride SL75212	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Betaxolol Hydrochloride is a selective beta1 adrenergic receptor blocker that can be used for the research of hypertension and glaucoma.

HY-B0381

Betaxolol	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Betaxolol is a selective beta1 adrenergic receptor blocker that can be used for the research of hypertension and glaucoma.

HY-100607A

Landiolol hydrochloride ONO1101 hydrochloride	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Landiolol hydrochloride (ONO1101 hydrochloride) is a highly beta1 selective ultra-short acting *beta*-blocker (β1/β2 selectivity = 255:1, a half-life of 4 min)， acts as an adrenoceptor antagonist.

HY-136214

R-BC154 acetate	Integrin	Cancer Inflammation/Immunology
R-BC154 acetate is a selective fluorescent *α₉β₁* integrin antagonist. R-BC154 acetate acts as a useful high affinity, activation dependent integrin probe, which can be used to investigate α9β1 and α4β1 integrin binding activity.

HY-148258

GDC-2394	NOD-like Receptor (NLR) Interleukin Related Caspase	Inflammation/Immunology
GDC-2394 is an orally active and selective NLRP3 inhibitor, and also inhibits *IL-1β* with IC₅₀s of 0.4 μM (human IL-1β) and 0.1 μM (mouse IL-1β). GDC-2394 inhibits NLRP3-induced caspase-1 activity without inhibiting NLRC4-dependent inflammasome activation.

HY-B0203A

Nebivolol hydrochloride R 065824 hydrochloride	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Nebivolol (R 065824) hydrochloride is an orally active beta receptor blocker and has the high beta(1)-receptor affinity.Nebivolol hydrochloride has direct vasodilator properties and adrenergic blocking characteristics. Nebivolol hydrochloride can be used for the research of kinds of diseases such as hypertension, coronary artery disease, congestive heart failure and ischemic heart disease.

HY-B0203

Nebivolol R 065824	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Nebivolol (R 065824) is an orally active beta receptor blocker and has the high beta(1)-receptor affinity. Nebivolol has direct vasodilator properties and adrenergic blocking characteristics. Nebivolol can be used for the research of kinds of diseases such as hypertension, coronary artery disease, congestive heart failure and ischemic heart disease.

HY-N7466

Mezerein	PKC	Cancer
Mezerein is a PKC activator that exhibits antileukemic properties. Mezerein inhibits the growth of yeast expressing PKC alpha (IC₅₀=1190 nM), PKC beta1 (IC₅₀=908 nM), and PKC delta (IC₅₀=141 nM) but not of yeast expressing PKC.

HY-101327

Xamoterol Corwin; ICI 118587	Adrenergic Receptor	Cardiovascular Disease
Xamoterol is a selective and potent agonist of beta1-adrenergic receptor. Xamoterol has the potential for the research of arrhythmogenesis. Xamoterol has the potential for the investigating the relationship between β1-adrenergic stimulation and IKr.

HY-138542

RO0270608
Integrin Inflammation/Immunology

RO0270608, the active metabolite of R411, is a dual alpha4beta1-alpha4beta7 (α4β1/α4β7) integrin antagonist. Antiinflammatory activity.

RO0270608	Integrin	Inflammation/Immunology
RO0270608, the active metabolite of R411, is a dual **alpha4beta1-alpha4beta7 (α4β1/α4β7)** integrin antagonist. Antiinflammatory activity.

HY-101327A

Xamoterol hemifumarate Corwin hemifumarate; ICI 118587 hemifumarate	Adrenergic Receptor	Cardiovascular Disease
Xamoterol hemifumarate is a selective and potent agonist of beta1-adrenergic receptor. Xamoterol hemifumarate has the potential for the research of arrhythmogenesis. Xamoterol hemifumarate has the potential for the investigating the relationship between β1-adrenergic stimulation and IKr.

HY-B0381S

Betaxolol-d5	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Betaxolol-d5 is the deuterium labeled Betaxolol. Betaxolol is a selective beta1 adrenergic receptor blocker that can be used for the research of hypertension and glaucoma.

HY-121607

INI-43
Others Cancer

INI-43, a Kpnβ1 inhibitor, interferes with the nuclear localization of Kpnβ1 and known Kpnβ1 cargoes, NFAT, NFκB, AP-1 and NFY.

INI-43	Others	Cancer
INI-43, a Kpnβ1 inhibitor, interferes with the nuclear localization of Kpnβ1 and known Kpnβ1 cargoes, NFAT, NFκB, AP-1 and NFY.

HY-151427

TGFβ1-IN-1	TGF-β Receptor	Inflammation/Immunology
TGFβ1-IN-1 (compound 42) is a potent, orally active *TGF-β1* inhibitor. TGFβ1-IN-1 inhibits the upregulation of TGF-β1-induced fibrosis markers (α-SMA and fibronectin) and can be used in liver fibrosis disease studies.

HY-112769

EX229	AMPK	Metabolic Disease
EX229, a Benzimidazole derivative, is a potent and allosteric activator of AMP-activated protein kinase (AMPK), with K_ds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1 and α1β2γ1 in biolayer interferometry, respectively.

HY-A0249

Bevantolol	Adrenergic Receptor	Cardiovascular Disease
Bevantolol is a selective β-1 adrenoceptor antagonist. Bevantolol can be used for the research of angina pectoris and hypertension.

HY-P1787

β-Amyloid (4-10)	Amyloid-β	Neurological Disease
β-Amyloid (4-10) is an epitope for the polyclonal anti-Aβ(1-42) antibody, reduces amyloid deposition in a transgenic Alzheimer disease mouse model.

HY-120270

PF-06679142	AMPK	Metabolic Disease
PF-06679142 (Compound 10) is a potent, orally active AMPK activator with an EC₅₀ of 22 nM against *α1β1γ1-AMPK. PF-06679142 can be used for diabetic nephropathy research.*

HY-108013

Armillarisin A
Interleukin Related Inflammation/Immunology

Armillarisin A has the potential for the ulcerative colitis (UC) study. Armillarisin A increases IL-4 and lower IL-1β.

Armillarisin A	Interleukin Related	Inflammation/Immunology
Armillarisin A has the potential for the ulcerative colitis (UC) study. Armillarisin A increases IL-4 and lower IL-1β.

HY-151343

NLRP3-IN-10	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-10 is a potent NLRP3 inhibitor, inhibits IL-1β release with an IC₅₀ value of 251.1 nM. NLRP3-IN-10 suppresses NLRP3 inflammasome activation by attenuating ASC speck formation.

HY-B0381AS

Betaxolol-d7 hydrochloride SL75212-d7	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Betaxolol-d7 hydrochloride (SL75212-d7) is the deuterium labeled Betaxolol hydrochloride. Betaxolol Hydrochloride is a selective beta1 adrenergic receptor blocker that can be used for the research of hypertension and glaucoma.

HY-N3514

Kuwanon E
Others Cancer

Kuwanon E is a flavonoid isolated from Morus alba, cytotoxic to human monocytic leukemic cell lines, and reduces the level of IL-1β.
HY-123052

Ac-PAL-AMC
Proteasome Inflammation/Immunology

Ac-PAL-AMC is a fluorogenic substrate specific for 20S proteasome LMP2/β1i activity.

Kuwanon E	Others	Cancer
Kuwanon E is a flavonoid isolated from Morus alba, cytotoxic to human monocytic leukemic cell lines, and reduces the level of IL-1β.

Ac-PAL-AMC	Proteasome	Inflammation/Immunology
Ac-PAL-AMC is a fluorogenic substrate specific for 20S proteasome *LMP2/β1i* activity.

HY-134130

Integrin modulator 1	Integrin	Inflammation/Immunology
Integrin modulator 1 is a potent and selective α4β1 integrin agonist, with an IC₅₀ of 9.8 nM for RGD-binding α4β1. Integrin modulator 1 increases cell adhesion mediated by α4β1 integrin, with an EC₅₀ of 12.9 nM.

HY-103683

PF-06409577
AMPK Metabolic Disease

PF-06409577 is a potent and selective allosteric activator of AMPK α1β1γ1 isoform with an EC₅₀ of 7 nM.

PF-06409577	AMPK	Metabolic Disease
PF-06409577 is a potent and selective allosteric activator of AMPK α1β1γ1 isoform with an EC₅₀ of 7 nM.

HY-16708A

ZLN024 hydrochloride	AMPK	Metabolic Disease
ZLN024 hydrochloride is an AMPK allosteric activator. ZLN024 directly activates recombinant AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1 and AMPK α2β2γ1 heterotrimer with EC₅₀s of 0.42 µM, 0.95 µM, 1.1 µM and 0.13 µM, respectively.

HY-16708

ZLN024	AMPK	Metabolic Disease
ZLN024 is an AMPK allosteric activator. ZLN024 directly activates recombinant AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1 and AMPK α2β2γ1 heterotrimer with EC₅₀s of 0.42 µM, 0.95 µM, 1.1 µM and 0.13 µM, respectively.

HY-14823

Sobetirome GC-1; QRX-431	Thyroid Hormone Receptor	Metabolic Disease Endocrinology
Sobetirome (GC-1) is a thyroid hormone receptor β (TRβ)-specific agonist which bind selectively to TRβ-1 with an EC₅₀ of 0.16 μM.

HY-111413

c(phg-isoDGR-(NMe)k)
Integrin Cancer

c(phg-isoDGR-(NMe)k) is a selective and potent α5β1-integrin ligand with an IC₅₀ of 2.9 nM.

c(phg-isoDGR-(NMe)k)	Integrin	Cancer
c(phg-isoDGR-(NMe)k) is a selective and potent *α5β1-integrin* ligand with an IC₅₀ of 2.9 nM.

HY-101514

β3-AR agonist 1	Adrenergic Receptor	Cardiovascular Disease Endocrinology
β3-AR agonist 1 (compound 15) is a highly potent, selective, and orally available β3-adrenergic receptor (β3-AR) agonist (EC₅₀=18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/β3, and α1A/β3>556-fold).

HY-15746

Dobutamine hydrochloride	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion.

HY-15746A

Dobutamine	Adrenergic Receptor	Endocrinology Cardiovascular Disease
Dobutamine is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine can increase cardiac output and correct hypoperfusion.

HY-N6712

Thiolutin Acetopyrrothin	Bacterial Antibiotic Endogenous Metabolite	Infection Metabolic Disease
Thiolutin (Acetopyrrothin) is a disulfide-containing antibiotic and anti-angiogenic compound produced by Streptomyces. Thiolutin inhibits the JAMM metalloproteases Csn5, Associated-molecule-with-the-SH3-Domain-of-STAM (AMSH) and Brcc36. Thiolutin is a potent and selective inhibitor of endothelial cell adhesion accompanied by rapid induction of Heat-shock protein beta-1 (Hsp27) phosphorylation.

HY-17497A

Acebutolol hydrochloride	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Acebutolol hydrochloride is an orally active β1 adrenergic receptor (β1AR) antagonist. Acebutolol hydrochloride is used in the treatment of hypertension, angina pectoris and cardiac arrhythmias.

HY-17497

Acebutolol	Adrenergic Receptor	Cardiovascular Disease
Acebutolol is an orally active β1 adrenergic receptor (β1AR) antagonist. Acebutolol is used for hypertension, angina pectoris and cardiac arrhythmias research.

HY-111413A

c(phg-isoDGR-(NMe)k) TFA
Integrin Cancer

c(phg-isoDGR-(NMe)k) TFA is a selective and potent α5β1-integrin ligand with an IC₅₀ of 2.9 nM.

HY-100445

αvβ1 integrin-IN-1	Integrin	Cancer Cardiovascular Disease
αvβ1 integrin-IN-1 (Compound C8) is a potent and selective αvβ1 integrin inhibitor with an IC₅₀ of 0.63 nM. Antifibrotic effects.

HY-15770

TR-14035	Integrin	Inflammation/Immunology
TR-14035 is a orally active dual α₄β₇/α₄β₁ integrin antagonist, with IC₅₀ s of 7 nM and 87 nM for α₄β₇ and α₄β₁, respectively. TR-14035 can be used for the research of inflammation and autoimmune diseases.

HY-100445A

αvβ1 integrin-IN-1 TFA	Integrin	Cancer Cardiovascular Disease
αvβ1 integrin-IN-1 TFA (Compound C8) is a potent and selective αvβ1 integrin inhibitor with an IC₅₀ of 0.63 nM. Antifibrotic effects.

HY-147038

AMPK activator 8	AMPK	Metabolic Disease
AMPK activator 8 (compound 2) is an AMP-activated protein kinase (AMPK) activator with EC₅₀s of 11, 27, 4, 2, and 4 nM for rAMPK α1β1γ1, rAMPK α2β1γ1, rAMPK α1β2γ1, rAMPK α2β2γ1, rAMPK α2β2γ3, respectively. AMPK activator 8 can be used for the research of type 2 diabetes.

HY-15746B

Dobutamine tartrate	Adrenergic Receptor	Endocrinology Cardiovascular Disease
Dobutamine tartrate is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine tartrate is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine tartrate can increase cardiac output and correct hypoperfusion.

HY-101860

GIBH-130	Interleukin Related	Neurological Disease
GIBH-130 is an effective inhibitor of neuroinflammation. GIBH-130 significantly suppresses the *IL-1β* secretion by activated microglia (IC₅₀=3.4 nM).

HY-U00066

Cicloprolol hydrochloride
Adrenergic Receptor Cardiovascular Disease Endocrinology

Cicloprolol is a partial β 1-adrenoceptor agonist .
HY-10401

VX-702
p38 MAPK Autophagy Inflammation/Immunology

VX-702 is a highly selective inhibitor of p38α MAPK, 14-fold higher potency against the p38α versus p38β.

HY-P3522

REDV	Integrin	Cancer
REDV is the minimal active sequence within the CS5 site of the alternatively spliced type III connecting segment (IIICS) region of fibronectin. REDV can mediate adhesion to the IIICS region of plasma fibronectin by binding the integrin alpha 4 beta 1(α4β1). REDV can be used for the research of cell adhesion.

HY-15746S1

(rac)-Dobutamine-d6 hydrochloride	Adrenergic Receptor	Cardiovascular Disease Endocrinology
(Rac)-Dobutamine-d6 hydrochloride is a labelled racemic Dobutamine hydrochloride. Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion.

HY-15746S

(rac)-Dobutamine-d4 hydrochloride	Adrenergic Receptor	Cardiovascular Disease Endocrinology
(Rac)-Dobutamine-d4 hydrochloride is a labelled racemic Dobutamine hydrochloride. Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion.

HY-151252

NIC-0102	Proteasome NOD-like Receptor (NLR)	Inflammation/Immunology
NIC-0102 is an orally active proteasome inhibitor (pIC₅₀=7.55) that specifically inhibits NLRP3 inflammatory vesicle activation. NIC-0102 shows potent anti-inflammatory effects in a model of dextran sulfate sodium (DSS)-induced ulcerative colitis. NIC-0102 also inhibits production of pro-IL-1β.

HY-P2267

LDV
Integrin Others

LDV, a tripeptide, is a non-fluorescent analog of LDV-FITC. LDV is a α4β1 integrin (VLA-4) ligand, and binds α4β1 integrin in leukemia cells.

HY-117432

JC-171	NOD-like Receptor (NLR)	Inflammation/Immunology
JC-171 is a selective NLRP3 inflammasome inhibitor, with an IC₅₀ of 8.45 μM for inhibiting LPS/ATP-induced interleukin-1β (IL-1β) release from J774A.1 macrophages.

HY-75385

Zaurategrast ethyl ester CDP323; UCB1184197	Integrin	Inflammation/Immunology
Zaurategrast ethyl ester (CDP323), the ethyl ester prodrug of CT7758, is a *α4β1/α4β7* integrin antagonist used for the treatment of inflammatory and autoimmune disorders.

HY-103221

MeBIO	Aryl Hydrocarbon Receptor GSK-3 CDK	Others
MeBIO is a potent AhR (aryl hydrocarbon receptor) agonist, with IC₅₀ of 44 μM (GSK-3) and 55 μM (CDK1/cyclin B), respectively. MeBIO is inactive on GSK-3β.

HY-75385A

Zaurategrast ethyl ester sulfate CDP323 sulfate; UCB1184197 sulfate	Integrin	Inflammation/Immunology
Zaurategrast ethyl ester sulfate (CDP323 sulfate), the ethyl ester prodrug of CT7758, is a *α4β1/α4β7* integrin antagonist used for the treatment of inflammatory and autoimmune disorders.

HY-14126

BIO-1211	Integrin	Inflammation/Immunology
BIO-1211 is a highly selective and orally active α4β1 (VLA-4) inhibitor, with IC₅₀ values of 4 nM and 2 μM for α4β1 and α4β7, respectively.

HY-120019

Ac-YVAD-CHO L-709049	Interleukin Related	Inflammation/Immunology
Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human K_i values of 3.0 and 0.76 nM. Ac-YVAD-CHO can suppress the production of mature IL-lβ.

HY-112108

Chitosan oligosaccharide COS	AMPK Endogenous Metabolite	Cancer Metabolic Disease
Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine. Chitosan oligosaccharide (COS) activates AMPK and inhibits inflammatory signaling pathways including NF-κB and MAPK pathways.

HY-148210

AMPK activator 9	AMPK	Metabolic Disease
AMPK activator 9 (ZM-6) is a potent AMPK (α2β1γ1) activator with an EC₅₀ value of 1.1 µM. AMPK activator 9 has the potential for the research of type 2 diabetes.

HY-17498

Atenolol (RS)-Atenolol	Adrenergic Receptor	Neurological Disease Endocrinology
Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a K_i of 697 nM atβ1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris.

HY-128591

DIPQUO	Phosphatase	Metabolic Disease
DIPQUO is an activator of the bone marker alkaline phosphatase (ALP), with an EC₅₀ of 6.27 μM in C2C12 cells. DIPQUO promotes mouse and human osteoblast differentiation via activation of p38 MAPK-β.

HY-10336

Brivanib (alaninate) BMS-582664	VEGFR Autophagy	Cancer
Brivanib alaninate (BMS-582664) is an ATP-competitive inhibitor against VEGFR2 with an IC₅₀ of 25 nM; has moderate potency against VEGFR-1 and FGFR-1, but more than 240-fold against PDGFRβ.

HY-14951

Firategrast SB 683699	Integrin	Neurological Disease
Firategrast (SB 683699) is an orally active and specific α4β1/α4β7 integrin antagonist. Firategrast reduces trafficking of lymphocytes into the central nervous system (CNS) and decreases multiple sclerosis (MS) activity.

HY-N3552

Catalposide	NF-κB	Inflammation/Immunology
Catalposide, an iridoid glycoside that could be isolated from Catalpa ovate G. Don (Bignoniaceae), inhibits TNF-α, IL-1β, and IL-6 productions and NF-κB (p65) activation in lipopolysaccharide-activated RAW 264.7 macrophages.

HY-13715

Norepinephrine Levarterenol; L-Noradrenaline	Endogenous Metabolite Adrenergic Receptor Autophagy	Endocrinology Cardiovascular Disease
Norepinephrine (Levarterenol; L-Noradrenaline) is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α₁, α₂, β₁ receptors.

HY-13715A

Norepinephrine hydrochloride Levarterenol hydrochloride; L-Noradrenaline hydrochloride	Adrenergic Receptor Autophagy Endogenous Metabolite	Cardiovascular Disease Endocrinology Cancer
Norepinephrine (Levarterenol; L-Noradrenaline) hydrochloride is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α₁, α₂, β₁ receptors.

HY-145348

MK-5204
Others Infection

MK-5204 is an orally active β-1,3-glucan synthesis inhibitor.

HY-13715B

Norepinephrine bitartrate monohydrate Levarterenol bitartrate monohydrate; L-Noradrenaline bitartrate monohydrate	Adrenergic Receptor Autophagy Endogenous Metabolite	Cardiovascular Disease Endocrinology
Norepinephrine (Levarterenol; L-Noradrenaline) bitartrate monohydrate is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α₁, α₂, β₁ receptors.

HY-P0118B

Disitertide diammonium P144 diammonium	TGF-beta/Smad PI3K Apoptosis	Cancer
Disitertide (P144) diammonium is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor. Disitertide diammonium is also a PI3K inhibitor and an apoptosis inducer.

HY-P0118

Disitertide P144	TGF-beta/Smad PI3K Apoptosis	Cancer
Disitertide (P144) is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor. Disitertide (P144) is also a PI3K inhibitor and an apoptosis inducer.

HY-P0118A

Disitertide TFA P144 TFA	TGF-beta/Smad PI3K Apoptosis	Cancer
Disitertide (P144) TFA is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor. Disitertide TFA is also a PI3K inhibitor and an apoptosis inducer.

HY-N7697B

Chitobiose dihydrochloride
Others Others

Chitobiose dihydrochloride, a chitosan oligosaccharide, is a dimer of β-1,4-linked glucosamine units.

HY-126114

Lupeol acetate	COX Interleukin Related	Inflammation/Immunology
Lupeol acetate, a derivative of Lupeol, suppresses the progression of rheumatoid arthritis (RA) by inhibiting the activation of macrophages and osteoclastogenesis through downregulations of TNF-α, IL-1β, MCP-1, COX-2, VEGF and granzyme B.

HY-17498S2

(R)-Atenolol-d7	Adrenergic Receptor	Neurological Disease Endocrinology
(R)-Atenolol-d7 is the deuterium labeled Atenolol. Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a Ki of 697 nM atβ1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris.

HY-112813

TUG-1375	Free Fatty Acid Receptor	Metabolic Disease
TUG-1375 is an agonist of free fatty acid receptor 2 (FFA2/GPR43), with a pK_i of 6.69. TUG-1375 is inactive on FFA3, FFA4, PPARα, PPARγ, PPARδ, LXRα or LXRβ.

HY-19676

Pralnacasan VX-740; HMR 3480	Caspase	Inflammation/Immunology
Pralnacasan (VX-740) is a potent, selective, non-peptide and orally active interleukin-1β converting enzyme (ICE, caspase 1) inhibitor with a K_i of 1.4 nM. Pralnacasan inhibits proinflammatory cytokines IL-18, *IL-1β* , and IFN-γ. Pralnacasan has the potential for osteoarthritis and rheumatoid arthritis treatment.

HY-117388

THI0019	Integrin	Inflammation/Immunology
THI0019 is a potent integrin α4β1 (VLA-4) agonist with an EC₅₀ range of 1-2 μM. THI0019 induces stem/progenitor cells adhesion. THI0019 also regulates adhesion mediated by α4β7, α5β1 and αLβ2.

HY-124290

Carotegrast methyl AJM300	Integrin	Inflammation/Immunology
Carotegrast methyl (AJM300) is an orally active and selective α4 integrin antagonist. HCA2969, an active metabolite of Carotegrast methyl, is a specific and dual α4β1/α4β7 integrin antagonist. Carotegrast methyl prevents the development of colitis in mice.

HY-108810

Canakinumab Ilaris; ACZ 885	Interleukin Related	Inflammation/Immunology
Canakinumab (ACZ885) is a recombinant human *anti-IL-1β* monoclonal antibody. Canakinumab shows IC₅₀ values of 43.6 and 40.8 pM for human and marmoset IL-1β, respectively. The mode of action of canakinumab is based on the neutralization of IL-1β signaling, resulting in suppression of inflammation related to disorders of autoimmune origin.

HY-N0847

Micheliolide	NF-κB	Others
Micheliolide could effectively attenuate the high glucose-stimulated activation of NF-κB, the degradation of IκBα, and the expression of MCP-1, TGF-β1 and FN in rat mesangial cells (MCs).

HY-13715C

Norepinephrine tartrate Levarterenol tartrate; L-Noradrenaline tartrate	Endogenous Metabolite Adrenergic Receptor Autophagy	Endocrinology Cardiovascular Disease
Norepinephrine (Levarterenol; L-Noradrenaline) tartrate is a potent adrenergic receptor (AR) agonist. Norepinephrine tartrate activates α₁, α₂, β₁ receptors.

HY-131166

Curdlan
Others Others

Curdlan is a polysaccharide produced by bacteria and a homopolymer of glucose with β-1,3-glucosidic linkage.

HY-108473

CU-CPT 4a TLR3-IN-1	Toll-like Receptor (TLR)	Cancer
CU-CPT 4a (TLR3-IN-1) is a potent, highly selective TLR3 signaling inhibitor. CU-CPT 4a represses the expression of downstream signaling pathways mediated by the TLR3/dsRNA complex, including TNF-α and IL-1β.

HY-16990

Ac-YVAD-cmk Caspase-1 Inhibitor II	Caspase	Inflammation/Immunology
Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective *caspase-1* (IL-1beta converting enzyme, ICE)) inhibitor with neuroprotective and anti-inflammatory effects. Ac-YVAD-cmk effectively suppresses the expression of IL-1β and IL-18. Ac-YVAD-cmk inhibits pyroptosis in many diseases.

HY-N1499

Nystose
Others Metabolic Disease

Nystose is a tetrasaccharide with two fructose molecules linked via beta (1→2) bonds to the fructosyl moiety of sucrose.

HY-N0074

Byakangelicol	COX	Inflammation/Immunology
Byakangelicol, isolated from Angelica dahurica, inhibits interleukin-1beta (IL-1beta) -induced prostaglandin E2 (PGE2) release in A549 cells mediated by suppression of cyclooxygenase-2 (COX-2) expression and the activity of COX-2 enzyme. Byakangelicol has therapeutic potential as an anti-inflammatory drug on airway inflammation.

HY-19303

CRA-2059
Ser/Thr Protease Inflammation/Immunology

CRA-2059 is a highly specific and selective tryptase inhibitor, with a K_i of 620 pM for recombinant human tryptase-β (rHTβ).
HY-19303B

CRA-2059 TFA
Ser/Thr Protease Inflammation/Immunology

CRA-2059 is a highly specific and selective tryptase inhibitor, with a K_i of 620 pM for recombinant human tryptase-β (rHTβ).

HY-19303A

CRA-2059 hydrochloride	Ser/Thr Protease	Inflammation/Immunology
CRA-2059 hydrochloride is a highly specific and selective tryptase inhibitor, with a K_i of 620 pM for recombinant human tryptase-β (rHTβ).

HY-15102

MK-0429 L-000845704	Integrin	Inflammation/Immunology Cancer
MK-0429 (L-000845704) is an orally active, potent, selective and nonpeptide pan-integrin antagonist with IC₅₀ values of 1.6 nM, 2.8 nM, 0.1 nM, 0.7 nM, 0.5 nM and 12.2 nM for αvβ1, αvβ3, αvβ5, αvβ6, αvβ8 and α5β1, respectively.

HY-U00183

Epanolol Visacor; ICI141292	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Epanolol (Visacor; ICI141292) is a potent *β-adrenoceptor* partial agonist with a greater affinity for β1- than β2-adrenoceptors.

HY-N0604

Ginsenoside Rh1 Prosapogenin A2; Sanchinoside B2; Sanchinoside Rh1	PPAR TNF Receptor Interleukin Related Endogenous Metabolite	Inflammation/Immunology
Ginsenoside Rh1 (Prosapogenin A2) inhibits the expression of PPAR-γ, TNF-α, IL-6, and *IL-1β*.

HY-17498S

Atenolol-d7 (RS)-Atenolol-d7	Adrenergic Receptor	Neurological Disease Endocrinology
Atenolol-d7 ((RS)-Atenolol-d7) is the deuterium labeled Atenolol. Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a K_i of 697 nM atβ1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris.

HY-134655

D75-4590
Fungal Infection Inflammation/Immunology

D75-4590, a pyridobenzimidazole derivative and a β-1,6-glucan synthesis inhibitor, possesses antifungal activity.
HY-15726

ICI 89406
Adrenergic Receptor Metabolic Disease

ICI 89406 is a selective β1 adrenergic receptor antagonist amenable to labelling with positron emitters, for PET.
HY-12043

SB 525334
TGF-β Receptor Cancer

SB 525334 is a potent and selective transforming growth factor β1 receptor (ALK5) inhibitor with an IC₅₀ of 14.3 nM.

HY-P99171

Gevokizumab	Interleukin Related	Inflammation/Immunology
Gevokizumab is a potent anti-IL-1β antibody, negatively modulates *IL-1β* signaling through an allosteric mechanism. Gevokizumab selectively decreases the binding affinity of *IL-1β* for the IL-1 receptor type I (IL-1RI) signaling receptor instead of IL-1 counter-regulatory decoy receptor (IL-1 receptor type II).

HY-117623

PF-06685249 PF-249	AMPK	Metabolic Disease
PF-06685249 (PF-249) is a potent and orally active allosteric AMPK activator with an EC₅₀ of 12 nM for recombinant AMPK α1β1γ1. PF-06685249 can be used for diabetic nephropathy research.

HY-N2587

Irigenin	Integrin Apoptosis	Cancer
Irigenin is a is a lead compound, and mediates its anti-metastatic effect by specifically and selectively blocking *α9β1* and *α4β1* integrins binding sites on C-C loop of Extra Domain A (EDA). Irigenin shows anti-cancer properties. It sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells.

HY-N0722

Neochlorogenic acid trans-5-O-Caffeoylquinic acid	NF-κB Interleukin Related TNF Receptor COX	Inflammation/Immunology Cancer
Neochlorogenic acid is a natural polyphenolic compound found in dried fruits and other plants. Neochlorogenic acid inhibits the production of TNF-α and *IL-1β. Neochlorogenic acid suppresses iNOS and COX-2* protein expression. Neochlorogenic acid also inhibits phosphorylated NF-κB p65 and p38 MAPK activation.

HY-N0569

Madecassic acid	NO Synthase COX TNF Receptor Interleukin Related	Inflammation/Immunology
Madecassic acid is isolated from Centella asiatica (Umbelliferae). Madecassic acid has anti-inflammatory properties caused by iNOS, COX-2, TNF-alpha, *IL-1beta, and IL-6* inhibition via the downregulation of NF-κB activation in RAW 264.7 macrophage cells.

HY-P3557

Mibenratide	Adrenergic Receptor	Cardiovascular Disease
Mibenratide, a small cyclic peptide, is an adrenergic β1 receptor antagonist. Mibenratide can be used for heart failure research.

HY-103214

Bucindolol	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Bucindolol is a β1-adrenergic receptor blocker, with intrinsic sympathomimetic activity, used in the research of heart failure.

HY-103211

L748337	Adrenergic Receptor	Cancer Metabolic Disease Cardiovascular Disease
L748337 is a potent β3-adrenergic receptor antagonist and displays selectivity over β1 and β2 receptors. The K_i values of L748337 for β3-, β2- and β1-adrenoceptors are 4.0 nM, 204 nM and 390 nM, respectively. L748337 couples predominantly to G_i to activate MAPK signaling and increases phosphorylation of Erk1/2 with pEC₅₀ value of 11.6. L748337 can be used for the research of cancer, nonalcoholic fatty liver disease (NAFLD), and cardiovascular related diseases.

HY-141645

IMM-H007 WS070117	AMPK TGF-β Receptor NF-κB JNK AP-1	Metabolic Disease Inflammation/Immunology Cardiovascular Disease
IMM-H007 (WS070117) is an orally active and potent AMPK (AMP-activated protein kinase) activator and TGFβ1 (transforming growth factor β1) antagonist. IMM-H007 has protective effects in cardiovascular diseases via activation of AMPK. IMM-H007 negatively regulates endothelium inflammation through inactivating NF-κB and *JNK/AP1* signaling. IMM-H007 inhibits ABCA1 degradation. IMM-H007 resolves hepatic steatosis in HFD-fed hamsters by the regulation of lipid metabolism. IMM-H007 can be used for the research of nonalcoholic fatty liver disease (NAFLD) and inflammatory atherosclerosis.

HY-N0633

Muscone	Interleukin Related TNF Receptor NF-κB NOD-like Receptor (NLR)	Inflammation/Immunology Cardiovascular Disease
Muscone is the main active monomer of traditional Chinese medicine musk. Muscone inhibits NF-κB and NLRP3 inflammasome activation. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6), and ultimately improves cardiac function and survival rate.

HY-13954

A 839977	P2X Receptor	Neurological Disease Inflammation/Immunology
A 839977 is a P2X7 selective antagonist; it blocks BzATP-evoked calcium influx at recombinant human, rat and mouse P2X7 receptors (IC₅₀ values are 20 nM, 42 nM and 150 nM respectively) and reduces inflammatory and neuropathic pain in animal models; the antihyperalgesic effects of P2X7 receptor blockade are mediated by blocking the release of IL-1beta.

HY-113960

ERRα antagonist-1	Estrogen Receptor/ERR	Cancer
ERRα antagonist-1 (Compound A) is a selective and high affinity estrogen-related receptor α (ERRα) antagonist. ERRα antagonist-1 inhibits interaction of ERRα with Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β, the IC₅₀ values are 170 nM and 180 nM, respectively. ERRα antagonist-1 does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα or ERβ with PGC-1α or SRC-1.

HY-13535

ATN-161
Integrin Cancer

ATN-161 is a novel integrin α5β1 antagonist, which inhibits angiogenesis and growth of liver metastases in a murine model.

HY-B0076S

Bisoprolol-d7 hemifumarate	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Bisoprolol-d7 hemifumarate is the deuterium labeled Bisoprolol hemifumarate. Bisoprolol hemifumarate is a selective type β1 adrenergic receptor blocker.

HY-13535A

ATN-161 trifluoroacetate salt ATN-161 TFA salt	Integrin	Cancer
ATN-161 trifluoroacetate salt is a novel integrin α5β1 antagonist, which inhibits angiogenesis and growth of liver metastases in a murine model.

HY-110246

Quin C1	Others	Inflammation/Immunology
Quin C1 is a highly specific and potent agonist for formyl peptide receptor 2 (FPR2/ALX). Quin-C1 significantly reduces the neutrophil and lymphocyte counts in BALF, diminishes expression of TNF-α, IL-1β, KC, and TGF-β1, and decreases collagen deposition in lung tissue. Quin C1 has the potential for the research of lung injury.

HY-119037

UK-101	Proteasome Apoptosis	Cancer
UK-101 is a potent and selective immunoproteasome β1i (LMP2) inhibitor with an IC₅₀ value of 104 nM, displays 144- and 10-fold selectivity over β1c (IC₅₀=15 μM) and β5 subunit (IC₅₀=1 μM), respectivey. UK-101 induces cell apoptosis and can be used for the study of prostate cancer.

HY-13715S

(Rac)-Norepinephrine-d3 (formate)	Endogenous Metabolite Adrenergic Receptor Autophagy	Endocrinology Cardiovascular Disease
(Rac)-Norepinephrine-d3 (formate) is deuterium labeled Norepinephrine. Norepinephrine (Levarterenol; L-Noradrenaline) is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α1, α2, β1 receptors.

HY-13713

LY377604	Adrenergic Receptor	Metabolic Disease Endocrinology
LY377604 is a *human β₃-adrenergic* receptor agonist with an EC₅₀ of 2.4 nM and also a β₁- and β₂-adrenergic receptor** antagonist.

HY-13951

ICI 118,551 hydrochloride ICI 118551 hydrochloride	Adrenergic Receptor	Neurological Disease Endocrinology
ICI 118,551 (hydrochloride) is a highly selective β2 adrenergic receptor antagonist, with K_is of 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, respectively.

HY-119721

CP-424174
NOD-like Receptor (NLR) Inflammation/Immunology

CP-424174 is a reversible inhibitor against IL-1β processing with an IC₅₀ of 210 nM.CP-424174 indirectly inhibits NLRP3.

HY-119109

Laminaran	Others	Cancer
Laminaran is an *β-1-3-glucan* and a typical ligand for Dectin-1 from Eisenia Bicyclis, has potent immunomodulating, radioprotective, and anticancer activities. Laminaran is made up of β (1→3)-glucan with β (1→6)-branches and can be catalyzed by enzymes such as laminarinase (EC 3.2.1.6) that breaks the β (1→3) bonds. Laminaran is a promising immune stimulatory molecule for use in cancer immunotherapy.

HY-100506

GLPG0187
Integrin Cancer

GLPG0187 is a broad spectrum integrin receptor antagonist with antitumor activity; inhibits α_vβ₁-integrin with an IC₅₀ of 1.3 nM.

HY-N8218

Homoeriodictyol 7-O-β-D-glucoside	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
Homoeriodictyol 7-O-β-D-glucoside is a natural *platelet-activating* factor (PAF) antagonist. Homoeriodictyol 7-O-β-D-glucoside inhibits human and rabbit platelet aggregation induced by PAF, with an IC₅₀** of 0.8 μM.

HY-N7697F

Chitobiose
Others Others

Chitobiose, a chitosan oligosaccharide, is a dimer of β-1,4-linked glucosamine units. Chitobiose has orally activity and high antioxidant activity.

HY-107589A

BIO5192 hydrate	Integrin	Inflammation/Immunology
BIO5192 hydrate is a selective and potent integrin α4β1 (VLA-4) inhibitor (K_d<10 pM). BIO5192 hydrate selectively binds to α4β1 (IC₅₀=1.8 nM) over a range of other integrins. BIO5192 hydrate results in a 30-fold increase in mobilization of murine hematopoietic stem and progenitors (HSPCs) over basal levels.

HY-107589

BIO5192	Integrin	Inflammation/Immunology
BIO5192 is a selective and potent integrin *α4β1* (VLA-4) inhibitor (K_d<10 pM). BIO5192 selectively binds to α4β1 (IC₅₀=1.8 nM) over a range of other integrins. BIO5192 results in a 30-fold increase in mobilization of murine hematopoietic stem and progenitors (HSPCs) over basal levels.

HY-107327

Carazolol (±)-Carazolol; DL-Carazolol; Suacron	Adrenergic Receptor	Cardiovascular Disease
Carazolol is a β₁/β₂ adrenoceptor antagonist of high potency used in the research of hypertension. Carazolol is also a potent, selective *β₃-adrenoceptor* agonist.

HY-N7176

Kaempferol 3-O-β-D-glucuronide Kaempferol-3-glucuronide; Kaempferol-3-O-glucuronide	Interleukin Related	Inflammation/Immunology
Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-glucuronide), one conjugated kaempferol metabolite, has anti-inflammatory effect. Kaempferol 3-O-β-D-glucuronide significantly inhibits various pro-inflammatory mediators like IL-1β, NO, PGE2, and LTB4. Kaempferol 3-O-β-D-glucuronide upregulates the secretion of anti-inflammatory cytokine IL-10.

HY-119802

Practolol	Adrenergic Receptor	Cardiovascular Disease
Practolol is a potent and selective β1-adrenergic receptor antagonist. Practolol can be used for the research of cardiac arrhythmias.

HY-150124

K34c
Integrin Cancer

K34c is a potent and selective α5β1 integrin antagonist. K34c can be used for glioblastoma research.

HY-119039

RU-301	TAM Receptor	Cancer Inflammation/Immunology
RU-301 is a pan TAM inhibitor that blocks Gas6-induced TAM activation and tumorigenicity. RU-301 significantly reduces nonalcoholic steatohepatitis (NASH) fibrosis, along with attenuates ERK activation and TGFβ1 expression. RU-301 can be used in studies of cancer and nonalcoholic steatohepatitis.

HY-108831

Natalizumab	Integrin	Inflammation/Immunology
Natalizumab is a recombinant, humanized IgG4 monoclonal antibody, binds to α4β1-integrin and blocks its interaction with vascular cell adhesion molecule-1 (VCAM-1). Natalizumab can be used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease. Natalizumab is also the first targeted therapy which blocks an essential mechanism for lymphocyte entry to the CNS and thus prevents acute demyelinating relapses.

HY-111509

TAK-828F	ROR	Inflammation/Immunology
TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (binding *IC₅₀*=1.9 nM, reporter gene *IC₅₀*=6.1 nM). TAK-828F shows excellent RORγt isoforms selectivity (>5000-fold selectivity against human RORα and RORβ).

HY-N1915

Cellohexaose	Endogenous Metabolite	Metabolic Disease
Cellohexaose is a glucose polymer with two or more glucose monomers produced from the breakdown of cellulose, consisting of a condensation of beta (1-4) linked D-glucose monomers.

HY-N2509

Iristectorigenin B Iristectrigenin B	LXR	Cardiovascular Disease
Iristectorigenin B (Iristectrigenin B) is a liver X receptor (LXR) modulator. Iristectrigenin B stimulates the transcriptional activity of both LXR-α and LXR-β.

HY-111513

4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine	Amyloid-β	Neurological Disease
4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent which binds to *Amyloid-β* (1-40) with a K_D of 1.7 nM.

HY-131945

CU-115	Toll-like Receptor (TLR)	Inflammation/Immunology
CU-115 is a potent TLR8 antagonist (IC₅₀=1.04 µM), and shows selective for TLR8 over TLR7 (IC₅₀=>50 µM). CU-115 decreases TNF-α and IL-1β production activated by R-848 in THP-1 cells.

HY-P1060

LPYFD-NH2	Amyloid-β	Neurological Disease
LPYFD-NH2, a pentapeptide, exerts some inhibitory effect on the aggregation of Aβ(1-42). LPYFD-NH2 can be used for the research of Alzheimer’s disease.

HY-147119

INX-SM-6
ADC Cytotoxin Inflammation/Immunology

INX-SM-6 can be used for targeted delivery of anti-inflammatory agent. INX-SM-6 inhibits LPS-induced IL-1β production in human PBMCS.

HY-N0042

Ginsenoside Rc Panaxoside Rc	GABA Receptor TNF Receptor Interleukin Related	Cancer Inflammation/Immunology Neurological Disease
Ginsenoside Rc, one of major Ginsenosides from Panax ginseng, enhances GABA receptor_A (GABA_A)-mediated ion channel currents (I_GABA). Ginsenoside Rc inhibits the expression of TNF-α and *IL-1β*.

HY-N10438

Ganodermaones B	Integrin	Inflammation/Immunology
Ganodermaones B (Compound 2) is a renal fibrosis inhibitor. Ganodermaones B inhibits TGF-β1-induced collagen I and fibronectin expression.

HY-17503

Metoprolol	Adrenergic Receptor Apoptosis	Cancer Infection Endocrinology Cardiovascular Disease
Metoprolol is an orally active, selective *β1-adrenoceptor* antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties.

HY-17497S

Acebutolol D7	Adrenergic Receptor	Endocrinology Cardiovascular Disease
Acebutolol D7 is a deuterium labeled Acebutolol. Acebutolol is a selective β1 adrenergic receptor antagonist used in the treatment of hypertension, angina pectoris and cardiac arrhythmias.

HY-115976

COX-2-IN-10	COX	Inflammation/Immunology
COX-2-IN-10 is a potent COX-2 inhibitor. COX-2-IN-10 inhibits the production of PGE₂ in concentration dependent manner (IC₅₀=2.54 µM). COX-2-IN-10 inhibits the expression of iNOS and COX-2 on mRNA and protein level . COX-2-IN-10 inhibits the production of IL-6, TNF-α and IL-1β.

HY-18644

CWHM-12
Integrin Cancer

CWHM-12 is a potent inhibitor of αV integrins with IC₅₀s of 0.2, 0.8, 1.5, and 1.8 nM for αvβ8, αvβ3, αvβ6, and αvβ1.

HY-127019

Nigericin	Sodium Channel NOD-like Receptor (NLR) Bacterial Apoptosis Antibiotic	Cancer Infection
Nigericin is an antibiotic derived from Streptomyces hygroscopicus that act as a K⁺/H⁺ ionophore, promoting K⁺/H⁺ exchange across mitochondrial membranes.Nigericin can be a *NLRP3* activator that induces the release of IL-1β as a NALP3-dependent manner. Nigericin triggers eryptosis, an effect paralleled by ROS formation, and in part due to induction of oxidative stress. Nigericin triggers apoptosis.

HY-146765

AMS-17	NOD-like Receptor (NLR)	Inflammation/Immunology Neurological Disease
AMS-17 is a potent NLRP3 inhibitor, inhibiting microglia activation in vitro and in vivo. AMS-17 also inhibits cytokines such as caspase-1, TNF-α, IL-1β and inducible nitric oxide synthase (iNOS) in N9 cells. AMS-17 can be used for researching inflammation-associated neurological disorders.

HY-P99020

Fresolimumab GC1008	TGF-β Receptor	Cancer Inflammation/Immunology
Fresolimumab (GC1008) is a high-affinity fully human monoclonal antibody that neutralizes the active form of human TGFβ1, TGFβ2, and TGFβ3. Fresolimumab can be used for the research of cancer and fibrotic diseases ^[1].

HY-100608

BMS453 BMS-189453	RAR/RXR	Cancer
BMS453 (BMS-189453), a synthetic retinoid, is a RARβ agonist and a RARα/RARγ antagonist. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ.

HY-P1060A

LPYFD-NH2 TFA	Amyloid-β	Neurological Disease
LPYFD-NH2 TFA, a pentapeptide, exerts some inhibitory effect on the aggregation of Aβ(1-42). LPYFD-NH2 TFA can be used for the research of Alzheimer’s disease.

HY-130778

N,N'-Diacetylchitobiose	Others Endogenous Metabolite	Others
N,N'-Diacetylchitobiose is a dimer of β(1,4) linked N-acetyl-D glucosamine. N,N'-Diacetylchitobiose is the hydrolysate of chitin and can be used as alternative carbon source by E. coli.

HY-17503B

Metoprolol tartrate	Adrenergic Receptor Apoptosis	Cancer Infection Endocrinology Cardiovascular Disease
Metoprolol tartrate is an orally active, selective *β1-adrenoceptor* antagonist. Metoprolol tartrate shows anti-inflammation, antitumor and anti-angiogenic properties.

HY-17503A

Metoprolol succinate	Adrenergic Receptor Apoptosis	Cardiovascular Disease Endocrinology Cancer
Metoprolol succinate is an orally active, selective *β1-adrenoceptor* antagonist. Metoprolol succinate shows anti-inflammation, antitumor and anti-angiogenic properties.

HY-U00183S

Epanolol-d5	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Epanolol-d5 (Visacor-d5) is the deuterium labeled Epanolol. Epanolol (Visacor) is a potent *β-adrenoceptor* partial agonist with a greater affinity for β1- than β2-adrenoceptors.

HY-17503C

Metoprolol fumarate CGP 2175C; Lopressor OROS	Adrenergic Receptor Apoptosis	Cancer Infection Endocrinology Cardiovascular Disease
Metoprolol fumarate (CGP 2175C) is an orally active, selective *β1-adrenoceptor* antagonist. Metoprolol fumarate shows anti-inflammation, antitumor and anti-angiogenic properties.

HY-17503S

Metoprolol-d7	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Metoprolol-d7 is the deuterium labeled Metoprolol. Metoprolol (Toprol) is a selective β1 receptor blocker used in treatment of several diseases of the cardiovascular system, especially hypertension.

HY-112071

Prenalterol	Adrenergic Receptor	Cardiovascular Disease
Prenalterol is a selective β1-adrenergic receptor agonist. Prenalterol has no effect on gut smooth muscle contractile activity. Prenalterol can be used for researching cardiovascular disease.

HY-103200

SR59230A hydrochloride	Adrenergic Receptor	Metabolic Disease Cardiovascular Disease
SR59230A hydrochloride is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC₅₀s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively.

HY-100672

SR59230A	Adrenergic Receptor	Metabolic Disease Cardiovascular Disease
SR59230A is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC₅₀s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively.

HY-N1431A

Tabersonine hydrochloride	Amyloid-β Others	Inflammation/Immunology Neurological Disease
Tabersonine hydrochloride is an indole alkaloid mainly isolated from Catharanthus roseus. Tabersonine disrupts Aβ(1-42) aggregation and ameliorates Aβ aggregate-induced cytotoxicity. Tabersonine has anti-inflammatory activities and is a potential therapeutic candidate for the treatment of ALI/ARDS.

HY-15483

DY131 GSK 9089	Estrogen Receptor/ERR Smo	Cancer Endocrinology
DY131 (GSK 9089) is a potent and selective ERRγ and ERRβ agonist. DY131displays inactive against ERRα, ERα and ERβ. DY131 also inhibits Smo signaling.

HY-123012

Lubabegron LY-488756	Adrenergic Receptor	Others
Lubabegron is a potent modulator of β-adrenergic receptor (β -AR). Lubabegron demonstrates antagonistic behavior at the β₁ and β ₂ receptor subtypes and agonistic behavior at the β ₃ receptor subtype in cattle. Lubabegron reduces NH₃ gas emissions from an animal or its waste.

HY-17503S2

(S)-Metoprolol-d7	Adrenergic Receptor	Cardiovascular Disease Endocrinology
(S)-Metoprolol-d7 is the deuterium labeled Metoprolol. Metoprolol (Toprol) is a selective β1 receptor blocker used in treatment of several diseases of the cardiovascular system, especially hypertension.

HY-17503S1

(R)-Metoprolol-d7	Adrenergic Receptor	Cardiovascular Disease Endocrinology
(R)-Metoprolol-d7 is the deuterium labeled Metoprolol. Metoprolol (Toprol) is a selective β1 receptor blocker used in treatment of several diseases of the cardiovascular system, especially hypertension.

HY-N1431

Tabersonine	Amyloid-β	Inflammation/Immunology Neurological Disease
Tabersonine is an indole alkaloid mainly isolated from Catharanthus roseus. Tabersonine disrupts Aβ(1-42) aggregation and ameliorates Aβ aggregate-induced cytotoxicity. Tabersonine has anti-inflammatory activities and acts as a potential therapeutic candidate for the treatment of ALI/ARDS.

HY-101355B

CGP 20712 A CGP 20712 mesylate	Adrenergic Receptor	Cardiovascular Disease
CGP 20712 A (CGP 20712 mesylate) is a highly selective *β1-adrenoceptor* antagonist with an IC₅₀ of 0.7 nM. CGP 20712 A exhibits ~10,000-fold selectivity over β2-adrenoceptors.

HY-147141

HS-276	IRAK TNF Receptor	Inflammation/Immunology
HS-276 is an orally active, potent and highly selective *TAK1* inhibitor, with a K_i of 2.5 nM. HS-276 shows significant inhibition of TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1, with IC₅₀ values of 8.25, 29, 33, 63, 125, 264, 270, 810, 1280, and 5585 nM, respectively. HS-276 can be used for rheumatoid arthritis (RA) research.

HY-N7142

DL-Norepinephrine hydrochloride	Adrenergic Receptor	Neurological Disease Endocrinology
DL-Norepinephrine hydrochloride is a synthetic phenylethylamine that mimics the sympathomimetic actions of the endogenous norepinephrine．DL-Norepinephrine hydrochloride is a neurotransmitter targets α1 and β1 adrenoceptors, has an increasing effect on subendocardial oxygen tension.

HY-N0506

Rosarin	Interleukin Related	Neurological Disease
Rosarin is a cinnamyl alcohol glycoside isolated from Rhodiola rosea. Rosarin has anti-inflammatory and neuroprotective effects. Rosarin supresses the expression of the proinflammatory factors iNOS, IL-1 β, and TNF- α in the kidney and prefrontal cortex of brain in mice .

HY-14189

Valategrast hydrochloride R-411	Integrin	Inflammation/Immunology
Valategrast hydrochloride (R-411) is a potent integrin α4β1 (VLA-4) and *α4β7* dual antagonist. Valategrast hydrochloride has the potential for Chronic obstructive pulmonary disease (COPD) and asthma treatment.

HY-124748A

ENMD-1068 hydrochloride	Protease Activated Receptor (PAR) Apoptosis	Inflammation/Immunology
ENMD-1068 hydrochloride is a selective *protease-activated* receptor 2 (PAR2*) antagonist. ENMD-1068 hydrochloride reduces hepatic stellate cell activation* and collagen expression by inhibiting *TGF-β1/Smad* signaling. ENMD-1068 hydrochloride also inhibits the proliferation of endometrial cells and induces apoptosis of epithelial cells in the lesion. ENMD-1068 hydrochloride can be used in the study of endometriosis and liver fibrosis.

HY-A0295

(R)-Propranolol hydrochloride	Adrenergic Receptor	Endocrinology Neurological Disease Cardiovascular Disease
(R)-Propranolol hydrochloride is a less active enantiomer of the β-adrenoceptor antagonist propranolol (HY-B0573). Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β₁AR and β₂AR with K_i values of 1.8 nM and 0.8 nM, respectively.

HY-141622

SDZ 224-015	Interleukin Related Caspase SARS-CoV	Infection Inflammation/Immunology
SDZ 224-015 is an orally active inhibitor of the **interleukin-1 beta (IL-1β) converting enzyme and caspase-1*. SDZ 224-015 possesses anti-COVID-19 activity, targeting M^pro (IC₅₀ of 30 nM).*

HY-B1081

Oxidopamine hydrochloride 6-Hydroxydopamine hydrochloride; 6-OHDA hydrochloride	Dopamine Receptor Autophagy Mitophagy COX PGE synthase Interleukin Related p38 MAPK Apoptosis Caspase	Cancer Neurological Disease
Oxidopamine (6-OHDA) hydrochloride is an antagonist of the neurotransmitter dopamine. Oxidopamine hydrochloride is a widely used neurotoxin and selectively destroys dopaminergic neurons. Oxidopamine hydrochloride promotes COX-2 activation, leading to PGE₂ synthesis and pro-inflammatory cytokine *IL-1β* secretion. Oxidopamine hydrochloride can be used for the research of Parkinson’s disease (PD), attention-deficit hyperactivity disorder (ADHD), and Lesch-Nyhan syndrome.

HY-119802S

Practolol-d7	Adrenergic Receptor	Cardiovascular Disease
(Rac)-Practolol-d7 is the deuterium labeled Practolol. Practolol is a potent and selective β1-adrenergic receptor antagonist. Practolol can be used for the research of cardiac arrhythmias.

HY-13013

(E)-SIS3	TGF-beta/Smad	Inflammation/Immunology
(E)-SIS3 is a potent and selective inhibitor of Smad3 with an IC₅₀ of 3 μM for Smad3 phosphorylation. (E)-SIS3 inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.

HY-129029

Bisoprolol	Adrenergic Receptor	Cancer Inflammation/Immunology Cardiovascular Disease
Bisoprolol is a potent, selective and orally active β1-adrenergic receptor blocker with little activity on β2-receptor. Bisoprolol has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research.

HY-P99235

Nadunolimab	Interleukin Related	Cancer
Nadunolimab is a human monoclonal IgG1 antibody targeting *IL1RAP. Nadunolimab blocks IL-1α* and IL-1β signaling and triggering antibody-dependent cellular cytotoxicity. Nadunolimab can be used in research of cancer.

HY-120829

Bisoprolol fumarate	Adrenergic Receptor	Cancer Inflammation/Immunology Cardiovascular Disease
Bisoprolol fumarate is a potent, selective and orally active β1-adrenergic receptor blocker with little activity on β2-receptor. Bisoprolol fumarate has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research.

HY-13671

LW6 HIF-1α inhibitor; LW8	HIF/HIF Prolyl-Hydroxylase Apoptosis	Cancer
LW6 (HIF-1α inhibitor) is a novel *HIF-1* inhibitor with an IC₅₀ of 4.4 μM. LW6 decreases *HIF-1α* protein expression without affecting HIF-1β expression.

HY-150965

NDT-30805	NOD-like Receptor (NLR)	Inflammation/Immunology
NDT-30805 is a selective NLRP3 inflammasome inhibitor. NDT-30805 is a triazolopyrimidinone derivative and inhibits IL-1β release in PBMCs with an IC₅₀ of 0.013 μM. NDT-30805 can be used for the research of inflammation and innate immunity.

HY-B0203BS

(rac)-Nebivolol-d8	Adrenergic Receptor	Cardiovascular Disease Endocrinology
(Rac)-Nebivolol-d8 ((rac)-R 065824-d8) is a labelled racemic Nebivolol. Nebivolol selectively inhibits β1- adrenergic receptor with IC₅₀ of 0.8 nM.

HY-10337

Brivanib BMS-540215	VEGFR Autophagy	Cancer
Brivanib (BMS-540215) is an ATP-competitive inhibitor against VEGFR2 with an IC₅₀ of 25 nM, and has moderate potency against VEGFR-1 and FGFR-1, but >240-fold against PDGFR-β.

HY-121186

Bevantolol hydrochloride	Adrenergic Receptor Calcium Channel	Metabolic Disease Neurological Disease
Bevantolol hydrochloride is a selective β1 and α1-adrenergic receptor antagonist with pK_i values of 7.83, 6.9 in rat cerebral cortex, respectively. Bevantolol hydrochloride is a potent Ca²⁺ antagonist.

HY-B0203BS1

(rac)-Nebivolol-d4	Adrenergic Receptor	Cardiovascular Disease Endocrinology
(Rac)-Nebivolol-d4 ((Rac)-R 065824-d4) is a labelled racemic Nebivolol. Nebivolol selectively inhibits β1- adrenergic receptor with IC₅₀ of 0.8 nM.

HY-17462

Adrenosterone (+)-Adrenosterone	Androgen Receptor Endogenous Metabolite	Cancer Endocrinology
Adrenosterone ((+)-Adrenosterone) is a competitive hydroxysteroid (11-beta) dehydrogenase 1 (HSD11β1) inhibitor. Adrenosterone is a steroid hormone with weak androgenic effect. Adrenosterone is a dietary supplement that can decrease fat and increase muscle mass. Adrenosterone acts as a suppressor of metastatic progression of human cancer cells.

HY-B1081A

Oxidopamine hydrobromide 6-Hydroxydopamine hydrobromide; 6-OHDA hydrobromide	Dopamine Receptor Autophagy Mitophagy COX PGE synthase Interleukin Related p38 MAPK Apoptosis Caspase	Neurological Disease Cancer
Oxidopamine (6-OHDA) hydrobromide is an antagonist of the neurotransmitter dopamine. Oxidopamine hydrobromide is a widely used neurotoxin and selectively destroys dopaminergic neurons. Oxidopamine hydrobromide promotes COX-2 activation, leading to PGE₂ synthesis and pro-inflammatory cytokine *IL-1β* secretion. Oxidopamine hydrobromide can be used for the research of Parkinson’s disease (PD), attention-deficit hyperactivity disorder (ADHD), and Lesch-Nyhan syndrome.

HY-101092

QS-21 Stimulon	NOD-like Receptor (NLR)	Inflammation/Immunology Cancer
QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and *Th1* cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18.

HY-N0619

Mulberroside A	TNF Receptor Interleukin Related Tyrosinase	Inflammation/Immunology
Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.). Mulberroside A decreases the expressions of TNF-α, *IL-1β, and IL-6* and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects. Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM.

HY-117239

SB-206606	Adrenergic Receptor	Cardiovascular Disease
SB-206606, a stereoisomer of BRL 37344, is a potentially specific, beta 3-adrenergic receptor (β₃-AR) ligand. The affinity of [3H]SB 206606 is 76 times higher for the β₃-AR than for the beta 1/beta 2-adrenergic receptors.

HY-B0076

Bisoprolol hemifumarate	Adrenergic Receptor	Cancer Endocrinology Inflammation/Immunology Cardiovascular Disease
Bisoprolol hemifumarate is a potent, selective and orally active β1-adrenergic receptor blocker with little activity on β2-receptor. Bisoprolol hemifumarate has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research.

HY-147295

Odetiglucan	Others	Cancer Inflammation/Immunology
Odetiglucan, a novel beta glucan, is a potent immunostimulant. Odetiglucan activates innate immune effector cells and triggers a coordinated anti-cancer immune response.

HY-123268

Ro 363	Adrenergic Receptor	Cardiovascular Disease
Ro 363, an effective inotropic stimulant, is a potent and highly selective *β1-adrenoceptor* agonist. RO 363 is a cardiovascular modulator that reduces diastolic blood pressure and pronounces increases in myocardial contractility.

HY-123268A

Ro 363 hydrochloride	Adrenergic Receptor	Cardiovascular Disease
Ro 363 hydrochloride, an effective inotropic stimulant, is a potent and highly selective *β1-adrenoceptor* agonist. Ro 363 hydrochloride is a cardiovascular modulator that reduces diastolic blood pressure and pronounces increases in myocardial contractility.

HY-17503AS

Metoprolol-d7 hydrochloride	Adrenergic Receptor	Cancer Infection Endocrinology Cardiovascular Disease
Metoprolol-d7 hydrochloride is the deuterium labeled Metoprolol. Metoprolol is an orally active, selective *β1-adrenoceptor* antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties.

HY-P1189

Echistatin	Integrin	Metabolic Disease Inflammation/Immunology
Echistatin, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of α_IIbβ₃, α_vβ₃ and *α₅β₁*.

HY-14302

Salmeterol GR33343X	Adrenergic Receptor	Endocrinology Inflammation/Immunology
Salmeterol (GR33343X) is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC₅₀s of 9.6, 6.1, and 5.9, respectively.

HY-17453

Salmeterol xinafoate GR 33343X xinafoate	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Salmeterol (GR 33343X) xinafoate is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC₅₀s of 9.6, 6.1, and 5.9, respectively.

HY-N8376

Fustin (±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone	Amyloid-β mAChR Cholinesterase (ChE)	Neurological Disease
Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) is a potent amyloid β (Aβ) inhibitor. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases the expression of acetylcholine (ACh) levels, choline acetyltransferase (ChAT) activity, and ChAT gene induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) decreases in acetyl cholinesterase (AChE) activity and AChE gene expression induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases muscarinic M1 receptor gene expression and muscarinic M1 receptor binding activity. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) can be used for Alzheimer's disease research.

HY-P1420

TAT-cyclo-CLLFVY	HIF/HIF Prolyl-Hydroxylase	Cancer
TAT-cyclo-CLLFVY is a cyclic peptide inhibitor of *HIF-1* heterodimerization that inhibits hypoxia signaling in cancer cells. TAT-cyclo-CLLFVY disrupts *HIF-1α/HIF-1β* protein-protein interaction with an IC₅₀ of 1.3 μM.

HY-N4285

Negletein 5,6-Dihydroxy-7-methoxyflavone	TNF Receptor Interleukin Related	Inflammation/Immunology Neurological Disease
Negletein is a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. Negletein shows promising anti-inflammatory activity via inhibition of TNF-α and *IL-1β* with IC₅₀ values of 16.4 and 10.8 μM, respectively.

HY-14190

Valategrast R-411 free base	Integrin	Inflammation/Immunology
Valategrast (R-411 free base) is a potent and orally active integrin α4β1 (VLA-4) and *α4β7* dual antagonist. Valategrast has the potential for Chronic obstructive pulmonary disease (COPD) and asthma treatment.

HY-144452

Immunoproteasome inhibitor 1	Proteasome	Cancer
Immunoproteasome inhibitor 1 is a potent, reversible, time-independent immunoproteasome and proteasome inhibitor (K_is of 1.18, 0.27, 1.91 μM in β5c, β1i, β5i submits, respectively). Immunoproteasome inhibitor 1 can be used for the treatment of certain neoplastic diseases.

HY-101019

Ossirene AS101	Interleukin Related Caspase	Cancer Inflammation/Immunology
Ossirene (AS101), an immunomodulatory tellurium compound, is a potent *IL-1β* inhibitor. Ossirene abolishes phosphorylation of STAT3 by inhibiting IL-10. Ossirene potently inhibits *Caspase-1* and is used for the autoimmune diseases and certain malignancies.

HY-16056

Arbutamine	Adrenergic Receptor	Cardiovascular Disease
Arbutamine is a short-acting, potent and nonselective *β-adrenoceptor* agonist. Arbutamine stimulates cardiac β₁-, tracheal β₂-, and adiopocyte β₃- adrenergic receptors. Arbutamine provides cardiac stress increases heart rate, cardiac contractility, and systolic blood pressure. Arbutamine can be used for cardiac stress agent ^[1].

HY-16056A

Arbutamine hydrochloride	Adrenergic Receptor	Cardiovascular Disease
Arbutamine hydrochloride is a short-acting, potent and nonselective *β-adrenoceptor* agonist. Arbutamine hydrochloride stimulates cardiac β₁-, tracheal β₂-, and adiopocyte β₃- adrenergic receptors. Arbutamine hydrochloride provides cardiac stress increases heart rate, cardiac contractility, and systolic blood pressure. Arbutamine hydrochloride can be used for cardiac stress agent ^[1].

HY-B0573A

(S)-(-)-Propranolol hydrochloride	Adrenergic Receptor	Inflammation/Immunology Cardiovascular Disease
(S)-(-)-Propranolol hydrochloride is a β-adrenergic receptor antagonist with log K_d values of -8.16, -9.08, and -6.93 for β₁, β₂, and β₃, respectively. (S)-(-)-Propranolol hydrochloride the active enantiomer of propranolol and can be s used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy.

HY-P1189A

Echistatin TFA	Integrin	Metabolic Disease Inflammation/Immunology
Echistatin TFA, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of α_IIbβ₃, α_vβ₃ and *α₅β₁*.

HY-17503BS

Metoprolol-d6 tartrate	Adrenergic Receptor	Cancer Infection Endocrinology Cardiovascular Disease
Metoprolol-d6 tartrate is the deuterium labeled Metoprolol tartrate. Metoprolol is an orally active, selective *β1-adrenoceptor* antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties.

HY-131040

NLRP3-IN-NBC6	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-NBC6 is a potent, selective NLRP3 inflammasome inhibitor (IC₅₀= 574 nM) that acts independently of Ca²⁺. NLRP3-IN-NBC6 inhibits Nigericin (HY-127019)-induced inflammasome activation in THP-1 cells and Imiquimod (HY-B0180)-induced IL-1β release from LPS-primed bone marrow-derived macrophages (BMDMs).

HY-P1420A

TAT-cyclo-CLLFVY TFA	HIF/HIF Prolyl-Hydroxylase	Cancer
TAT-cyclo-CLLFVY TFA is a cyclic peptide inhibitor of *HIF-1* heterodimerization that inhibits hypoxia signaling in cancer cells. TAT-cyclo-CLLFVY TFA disrupts *HIF-1α/HIF-1β* protein-protein interaction with an IC₅₀ of 1.3 μM.

HY-139727A

S(-)-Bisoprolol fumarate	Adrenergic Receptor	Cardiovascular Disease
S(-)-Bisoprolol fumarate is a S(-)-enantiomer of Bisoprolol fumarate. Bisoprolol fumarate is a potent, selective and orally active β1-adrenergic receptor blocker. Bisoprolol has little activity on β2-receptor and has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research.

HY-139727

S(-)-Bisoprolol	Adrenergic Receptor	Cardiovascular Disease
S(-)-Bisoprolol is a S(-)-enantiomer of Bisoprolol. Bisoprolol is a potent, selective and orally active β1-adrenergic receptor blocker. Bisoprolol has little activity on β2-receptor and has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research.

HY-P1266

α-Conotoxin EI	nAChR	Neurological Disease
α-Conotoxin EI is a selective *nicotinic acetylcholine α1β1γδ receptor* (nAChR) antagonist (IC₅₀=187 nM) and an α3β4 receptor inhibitor. α-Conotoxin EI can block muscle and ganglionic receptors.

HY-19717

DCVC S-[(1E)-1,2-dichloroethenyl]--L-cysteine	TNF Receptor	Inflammation/Immunology
DCVC (S-[(1E)-1,2-dichloroethenyl]--L-cysteine) is a bioactive metabolite of trichloroethylene (TCE). DCVC inhibits pathogen-stimulated pro-inflammatory cytokines IL-1β, IL-8, and TNF-α release from tissue cultures.

HY-P0299

LSKL, Inhibitor of Thrombospondin (TSP-1)	TGF-β Receptor	Cancer
LSKL, Inhibitor of Thrombospondin (TSP-1) is a latency-associated protein (LAP)-TGFβ derived tetrapeptide and a competitive *TGF-β1* antagonist. LSKL, Inhibitor of Thrombospondin (TSP-1) inhibits the binding of *TSP-1* to LAP and alleviates renal interstitial fibrosis and hepatic fibrosis. LSKL, Inhibitor of Thrombospondin (TSP-1) suppresses subarachnoid fibrosis via inhibition of *TSP-1*-mediated *TGF-β1* activity, prevents the development of chronic hydrocephalus and improves long-term neurocognitive defects following subarachnoid hemorrhage (SAH). LSKL, Inhibitor of Thrombospondin (TSP-1) can readily crosse the blood-brain barrier.

HY-P0299A

LSKL, Inhibitor of Thrombospondin (TSP-1) (TFA)	TGF-β Receptor	Cancer
LSKL, Inhibitor of Thrombospondin (TSP-1) TFA is a latency-associated protein (LAP)-TGFβ derived tetrapeptide and a competitive *TGF-β1* antagonist. LSKL, Inhibitor of Thrombospondin (TSP-1) TFA inhibits the binding of *TSP-1* to LAP and alleviates renal interstitial fibrosis and hepatic fibrosis. LSKL, Inhibitor of Thrombospondin (TSP-1) TFA suppresses subarachnoid fibrosis via inhibition of *TSP-1*-mediated *TGF-β1* activity, prevents the development of chronic hydrocephalus and improves long-term neurocognitive defects following subarachnoid hemorrhage (SAH). LSKL, Inhibitor of Thrombospondin (TSP-1) TFA can readily crosse the blood-brain barrier.

HY-100444

SIS3 free base	TGF-beta/Smad	Inflammation/Immunology
SIS3 free base is a potent and selective inhibitor of Smad3 phosphorylation. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1. SIS3 free base does not affect the phosphorylation of Smad2.

HY-135119

Salmeterol-D3	Adrenergic Receptor	Endocrinology Inflammation/Immunology
Salmeterol-D3 is a deuterium labeled Salmeterol. Salmeterol is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC₅₀s of 9.6, 6.1, and 5.9, respectively.

HY-10985

Marizomib Salinosporamide A; NPI-0052	Proteasome	Cancer
Marizomib (Salinosporamide A) is a second-generation, irreversible, brain-penetrant, pan-proteasome inhibitor. Marizomib inhibits the CT-L (β5), CT-T-laspase-like (C-L, β1) and trypsin-like (T-L, β2) activities of the 20S proteasome (IC₅₀=3.5, 28, and 430 nM, respectively).

HY-128859

EMT inhibitor-2	Cytochrome P450	Metabolic Disease
EMT inhibitor-2 (Compound 1) inhibits epithelial-mesenchymal transition (EMT) induced by substances such as IL-1β and TGF-β released from the immunocytes. EMT inhibitor-2 inhibits CYP3A4 testosteron and CYP2C9 with IC₅₀s of 49.72 and 5.54 μM, respectively.

HY-145721

Mongersen GED-0301	TGF-beta/Smad	Inflammation/Immunology
Mongersen (GED-0301) is a specific and orally active SMAD7 antisense oligonucleotide. Mongersen restores TGF-β1 activity leading to inhibition of inflammatory signals. Mongersen can attenuate Crohn's disease-like experimental colitis in mice.

HY-12308

TCS 2314
Integrin Inflammation/Immunology

TCS 2314 (compound 3) is orally active and selective very late antigen-4 (VLA-4, α4β1, CD49d/CD29) antagonist with an IC₅₀ of 4.4 nM.

HY-119515

Denopamine (R)-(-)-Denopamine; TA-064	Adrenergic Receptor	Cardiovascular Disease
Denopamine ((R)-(-)-Denopamine) is an orally active, selective *β1-adrenergic* agonist. Denopamine prolongs survival in a murine model of congestive heart failure induced by viral myocarditis: suppression of tumor necrosis factor-α production in the heart. Cardiovascular effects.

HY-119873

Celiprolol REV 5320	NO Synthase Adrenergic Receptor	Cardiovascular Disease
Celiprolol (REV 5320) is a potent, cardioselective and orally active β1-andrenoceptor r antagonist with partial β2 agonist activity, with K_i values of 0.14-8.3 μM. Celiprolol has antihypertensive and antianginal activity, and can be used for the research of cardiovascular disease such as high blood pressure.

HY-N6927

Isoforskolin Coleonol B	TNF Receptor Interleukin Related	Inflammation/Immunology
Isoforskolin is the principle active component of C. forskohlii native to China. Isoforskolin reduces the secretion of lipopolysaccharide (LPS)-induced cytokines, namely TNF-α, *IL-1β, IL-6* and IL-8, in human mononuclear leukocytes. Isoforskolin acts as an anti-inflammatory agent for the treatment of Lyme arthritis.

HY-129029S

Bisoprolol-d5	Adrenergic Receptor	Cardiovascular Disease
Bisoprolol-d5 is the deuterium labeled Bisoprolol. Bisoprolol is a potent, selective and orally active β1-adrenergic receptor blocker. Bisoprolol has little activity on β2-receptor and has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research.

HY-19888

GSK-1482160	P2X Receptor	Inflammation/Immunology
GSK-1482160 is an orally available negative allosteric modulator of the P2X7 receptor. P2X7 receptors are involved in the production of pro-inflammatory cytokines, such as Il-1β, by central and peripheral immune cells. GSK-1482160 has the potential for the research of inflammation diseases.

HY-B1264

Celiprolol hydrochloride	NO Synthase Adrenergic Receptor	Cardiovascular Disease
Celiprolol (REV 5320) is a potent, cardioselective and orally active β1-andrenoceptor r antagonist with partial β2 agonist activity, with K_i values of 0.14-8.3 μM. Celiprolol has antihypertensive and antianginal activity, and can be used for the research of cardiovascular disease such as high blood pressure.

HY-14300A

Vilanterol trifenatate GW642444 trifenatate	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Vilanterol trifenatate (GW642444 trifenatate) is a long-acting *β₂-adrenoceptor* (β₂-AR) agonist with inherent 24-hour activity. The pEC₅₀s for β₂-AR, β₁-AR and β₃-AR are 10.37, 6.98 and 7.36, respectively.

HY-14302S

Salmeterol-d4	Adrenergic Receptor	Endocrinology Inflammation/Immunology
Salmeterol-d4 is the deuterium labeled Salmeterol. Salmeterol (GR33343X) is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC₅₀s of 9.6, 6.1, and 5.9, respectively.

HY-N0619A

cis-Mulberroside A Mulberroside D	TNF Receptor Interleukin Related Tyrosinase	Inflammation/Immunology
cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.). Mulberroside A decreases the expressions of TNF-α, *IL-1β, and IL-6* and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory and anti-apoptotic effects. Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM.

HY-N10578

Genkwadaphnin	Others	Cancer
Genkwadaphnin is a daphnane diterpenoid, targeting of importin-β1 to reduce the nuclear accumulation of key CRPC drivers, and shut down their downstream oncogenic signaling. Genkwadaphnin shows potent anti-tumor activity and inhibits castration-resistant prostate cancer (CRPC) in vivo in mice.

HY-50754

gamma-secretase modulator 2	γ-secretase	Neurological Disease
gamma-secretase modulator 2 is a potent and selective γ-secretase modulator for treatment of Alzheimer's disease IC50 value: Target: γ-secretase γ-secretase modulator is modulation of the action of γ-secretase so as to Selectively attenuate production of Aβ(1-42) and hence find use in treatment or prevention of diseases associated with deposition of Aβ in the brain.

HY-P0297

Protease-Activated Receptor-4
Protease Activated Receptor (PAR) Others

Protease-Activated Receptor-4 is the agonist of proteinase-activated receptor-4 (PAR4).

HY-14300

Vilanterol GW642444	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Vilanterol (GW642444) is a long-acting *β₂-adrenoceptor* (β₂-AR) agonist with 24 h activity. The pEC₅₀s for β₂-AR,β₁-AR and β₃-AR is 10.37±0.05, 6.98±0.03 and 7.36±0.03, respectively.

HY-130252

YQ128	NOD-like Receptor (NLR) Interleukin Related	Inflammation/Immunology
YQ128 is a potent and selective second-generation NLRP3 (NOD-like receptor P3) inflammasome inhibitor with an IC₅₀ of 0.30 µM. YQ128 significantly and selectively suppresses the production of *IL-1β, but not TNF-α, and it can cross the BBB to reach the CNS. YQ128 has anti-inflammatory activity.*

HY-10426

XCT790	Estrogen Receptor/ERR Autophagy	Cancer
XCT-790 is a potent and selective inverse agonist for ERRα with an IC₅₀ value of 0.37 μM. XCT-790 induces cell death in chemotherapeutic resistant cancer cells. XCT-790 (Compound 12) is inactive against ERRγ and the estrogen receptors ERα and ERβ.

HY-18754

FR 167653 free base	p38 MAPK Autophagy	Endocrinology
FR 167653 free base, an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity. FR 167653 free base is effective in treating inflammation, relieving trauma and ischemia-reperfusion injury in vivo.

HY-129113

α-Chaconine	COX	Inflammation/Immunology
α-Chaconine inhibits the expressions of COX-2, *IL-1β, IL-6, and TNF-α* at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects.

HY-15507

VGX-1027 GIT 27	Interleukin Related TNF Receptor	Metabolic Disease Inflammation/Immunology
VGX-1027 is an orally active isoxazole compound that exhibits various immunomodulatory properties. VGX-1027 targets macrophages, reducing the production of the proinflammatory mediators TNF-α, IL-1β, IL-10. VGX-1027 has antidiabetogenic effects by limiting cytokine-mediated immunoinflammatory events.

HY-13335

PKCβ inhibitor 1	PKC Apoptosis	Cancer
PKCβ inhibitor 1 is a potent, ATP-competitive, and selective PKCβ inhibitor with IC₅₀s of 21 and 5 nM for human PKCβ1 and PKCβ2, respectively. PKCβ inhibitor 1 exhibits selectivity of more than 60-fold in favor of PKCβ2 relative to other PKC isozymes (PKCα, PKCγ, and PKCε).

HY-N7142S

DL-Norepinephrine-d6 hydrochloride	Adrenergic Receptor	Neurological Disease Endocrinology
DL-Norepinephrine-d6 hydrochloride is the deuterium labeled DL-Norepinephrine hydrochloride. DL-Norepinephrine hydrochloride is a synthetic phenylethylamine that mimics the sympathomimetic actions of the endogenous norepinephrine．DL-Norepinephrine hydrochloride is a neurotransmitter targets α1 and β1 adrenoceptors, has an increasing effect on subendocardial oxygen tension.

HY-19975

RN-1734	TRP Channel	Neurological Disease
RN-1734 is selective antagonist of the TRPV4 channel, completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC₅₀s for all three species (hTRPV4: 2.3 μM, mTRPV4: 5.9 μM, rTRPV4: 3.2 μM). RN-1734 clearly decreases the production of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) without altering the number of olig2-positive cells.

HY-P3653

α-Conotoxin M I	mAChR nAChR	Neurological Disease
α-Conotoxin M I is a potent and selective inhibitor of mAChR and *α1β1γδ nAChR, but has no effect on nicotine-stimulated dopamine release. α-Conotoxins are small, disulfide-rich peptides that competitively inhibit muscle and neuronal nicotinic AChRs.*

HY-126236

3,5-Diiodothyropropionic acid	Thyroid Hormone Receptor	Cardiovascular Disease Endocrinology
3,5-Diiodothyropropionic acid is a thyroid hormone analog, induces α-myosin heavy chain mRNA expression, binds to thyroid hormone receptor (TR), with K_a of 2.40 and 4.06 M^-1 for TRα1 and TRβ1, respectively.

HY-P0283

*Protease-Activated* Receptor-2, amide**	Protease Activated Receptor (PAR)	Cancer
Protease-Activated Receptor-2, amide (SLIGKV-NH₂) is a highly potent protease-activated receptor-2 (PAR2) activating peptide.

HY-B0573AS

(S)-(-)-Propranolol-d7 hydrochloride	Adrenergic Receptor	Inflammation/Immunology Cardiovascular Disease
(S)-(-)-Propranolol-d7 hydrochloride is the deuterium labeled (S)-(-)-Propranolol hydrochloride. (S)-(-)-Propranolol hydrochloride is a β-adrenergic receptor antagonist with log K_d values of -8.16, -9.08, and -6.93 for β₁, β₂, and β₃, respectively. (S)-(-)-Propranolol hydrochloride the active enantiomer of propranolol and can be s used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy.

HY-N7652

Terminolic acid	Bacterial	Infection Inflammation/Immunology
Terminolic acid is a pentacyclic triterpenoid glucoside isolated from Combretum racemosum. Terminolic acid can inhibit the pro-inflammatory cytokines by binding to receptor active site of IL-1β and IL-6, and enhance anti-inflammatory cytokines by binding to IL-4 receptor binding sites. Terminolic acid also exhibits moderate antibacterial activity.

HY-18754A

FR 167653 FR 167653 sulfate	p38 MAPK Autophagy	Endocrinology
FR 167653 (FR 167653 sulfate), an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity. FR 167653 (FR 167653 sulfate) is effective in treating inflammation, relieving trauma and ischemia-reperfusion injury in vivo.

HY-N6896

Isoviolanthin	TGF-beta/Smad	Cancer
Isoviolanthin, a flavonoid glycoside, could markedly inhibit TGF-β1-mediated migration and invasion by deactivating epithelial-mesenchymal transition (EMT) via the *TGF-β/Smad* and PI3K/Akt/mTOR pathways in HCC cells. Isoviolanthin exhibits no cytotoxic effects on normal liver LO2 cells.

HY-123495

CRANAD-28
Others Neurological Disease

CRANAD-28 is a robust fluorescent compound for visualization of amyloid beta plaques.

HY-114170

ML604440	Proteasome	Inflammation/Immunology
ML604440 is a specific and cell-permeable Proteasome β1i (LMP2) subunit inhibitor. ML604440 can be used in experimental colitis, EAE and autoimmune disease research. ML604440 shows synergistic effects and advantageous when combined with LMP7 inhibitor.

HY-B0449

Methacycline hydrochloride	Bacterial Antibiotic	Infection
Methacycline hydrochloride is a tetracycline antibiotic and can inhibits bacterial protein synthesis. Methacycline hydrochloride is a potent epithelial-mesenchymal transition (EMT) inhibitor. Methacycline hydrochloride blocks EMT in vitro and fibrogenesis in vivo without directly affecting TGF-β1 Smad signaling. Methacycline hydrochloride is an antimicrobial and has the potential for pulmonary fibrosis.

HY-107588

TC-I 15	Integrin	Cardiovascular Disease
TC-I 15 (TC-I-15) is an allosteric, collagen-binding integrin *α2β1* inhibitor with IC₅₀ values of 26.8 μM and 0.4 μM for GFOGER and GLOGEN, respectively. TC-I 15 inhibits platelet adhesion to collagen and thrombus deposition.

HY-17453S1

Salmeterol-13C6 xinafoate GR 33343X-13C6 xinafoate	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Salmeterol-13C6 (xinafoate) is the 13C6 labeled Salmeterol (xinafoate). Salmeterol (GR 33343X) xinafoate is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively.

HY-13306

Pyrintegrin	Integrin	Metabolic Disease
Pyrintegrin is an *β1-integrin* agonist and a 2,4-disubstituted pyrimidine that promotes embryonic stem cells survival. Pyrintegrin enhances cell-extracellular matrix (ECM) adhesion-mediated integrin signaling. Pyrintegrin can be used as a podocyte-protective agent and has robustly adipogenic.

HY-12753A

Debutyldronedarone hydrochloride SR35021 hydrochloride	Thyroid Hormone Receptor	Cardiovascular Disease
Debutyldronedarone (SR35021) hydrochloride, the main metabolite of Dronedarone, is a selective thyroid hormone receptor α₁ (TRα₁) inhibitor. Debutyldronedarone hydrochloride inhibits T3 binding to TRα₁ and TRβ₁ by 77% and 25%, respectively. Debutyldronedarone hydrochloride can be used for the research of arrhythmic.

HY-B0446

Naphazoline hydrochloride Naphthazoline hydrochloride	Adrenergic Receptor TNF Receptor Interleukin Related VEGFR	Inflammation/Immunology Cardiovascular Disease
Naphazoline (Naphthazoline) hydrochloride is a potent α-adrenergic receptor agonist. Naphazoline hydrochloride reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline hydrochloride reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF。Naphazoline hydrochloride can be used for non-bacterial conjunctivitis research.

HY-144307

Aurora A/PKC-IN-1	Aurora Kinase PKC	Cancer
Aurora A/PKC-IN-1 (Compound 2e) is a potent dual inhibitor of Aurora A (AurA) and PKC (α, β1, β2, and θ) kinases with IC₅₀s of 6.9 nM and 16.9 nM for AurA and PKCα, respectively. Aurora A/PKC-IN-1 has antiproliferative activity in breast cancer cells and antimetastatic activity.

HY-111326

Naphazoline Naphthazoline	Adrenergic Receptor TNF Receptor Interleukin Related VEGFR	Inflammation/Immunology Cardiovascular Disease
Naphazoline (Naphthazoline) is a potent α-adrenergic receptor agonist. Naphazoline reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF。Naphazoline can be used for non-bacterial conjunctivitis research.

HY-N0411

β-Carotene Provitamin A; beta-Carotene	Endogenous Metabolite Apoptosis Reactive Oxygen Species	Cancer Metabolic Disease
β-Carotene (Provitamin A), a carotenoid compound, is a naturally-occurring vitamin A precursor. β-Carotene is a modulator of reactive oxygen species (ROS), with antioxidant and antiinflammatory activities. β-Carotene may serve as an antioxidant or as a prooxidant, depending on its intrinsic properties as well as on the redox potential of the biological environment in which it acts. β-Carotene induces breast cancer cells apoptosis, with anticancer activities.

HY-N2337

11beta-Hydroxyprogesterone 11β-Hydroxyprogesterone	Endogenous Metabolite	Cardiovascular Disease
11beta-Hydroxyprogesterone is a potent inhibitors of 11β-Hydroxysteroid dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED₅₀ of 10 nM.

HY-14300AS

Vilanterol-d4 trifenatate GW642444-d4 trifenatate	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Vilanterol-d4 (trifenatate) is deuterium labeled Vilanterol (trifenatate). Vilanterol trifenatate (GW642444 trifenatate) is a long-acting β2-adrenoceptor (β2-AR) agonist with inherent 24-hour activity. The pEC50s for β2-AR, β1-AR and β3-AR are 10.37, 6.98 and 7.36, respectively.

HY-111326A

Naphazoline nitrate Naphthazoline nitrate	Adrenergic Receptor TNF Receptor Interleukin Related VEGFR	Inflammation/Immunology Cardiovascular Disease
Naphazoline (Naphthazoline) nitrate is an α-adrenergic receptor agonist. Naphazoline nitrate reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline nitrate reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF。Naphazoline nitrate can be used for non-bacterial conjunctivitis research.

HY-151876

Glucocorticoid receptor modulator 1	Glucocorticoid Receptor NF-κB AP-1	Inflammation/Immunology
Glucocorticoid receptor modulator 1 is a highly potent and orally active non-steroidal selective glucocorticoid receptor modulator with an IC₅₀ value of 9 nM and 130 nM for NF-κB and *AP-1, respectively. Glucocorticoid receptor modulator 1 can effectively reduce the expression of inflammatory factors IL-6, IL-1β, TNF-α, also can relieve dermatitis in mice.*

HY-W396714

Succinic acid sodium Wormwood acid sodium	Potassium Channel	Neurological Disease
Succinic acid sodium is a potent and orally active anxiolytic agent. Succinic acid sodium shows inhibitory effects on colonic epithelial cell proliferation in vivo. Succinic acid sodium can down-regulate the expression of *KCNMB1* (potassium channel subunit β1) and *TET1* (ten‑eleven translocation 1). Succinic acid sodium can be used for gestational hypertension research.

HY-B0573

Propranolol hydrochloride	Adrenergic Receptor Bacterial	Neurological Disease Endocrinology Cancer
Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with K_i values of 1.8 nM and 0.8 nM, respectively. Propranolol hydrochloride inhibits [³H]-DHA binding to rat brain membrane preparation with an IC₅₀ of 12 nM. Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy.

HY-N1326

Santamarine Santamarin; Balchanin	Others	Inflammation/Immunology
Santamarine (Santamarin), a sesquiterpene lactone, increases HO-1 expression through Nrf2 translocation and suppresses NO, PGE2, TNF-α, and IL-1β production through inhibition of NF-κB translocation in LPS-induced macrophages. Santamarine shows anti-photoaging properties via inhibition of MAPK/AP-1 and stimulation of TGF-β/Smad signaling in UVA-irradiated human dermal fibroblasts (HDFs). Antioxidant activities.

HY-B0573B

Propranolol	Adrenergic Receptor Bacterial	Neurological Disease Cardiovascular Disease Endocrinology Cancer
Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with K_i values of 1.8 nM and 0.8 nM, respectively. Propranolol inhibits [³H]-DHA binding to rat brain membrane preparation with an IC₅₀ of 12 nM. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy.

HY-17453S

Salmeterol-d3 xinafoate GR 33343X-d3 xinafoate	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Salmeterol-d3 (GR 33343X-d3) xinafoate is the deuterium labeled Salmeterol xinafoate. Salmeterol (GR 33343X) xinafoate is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC₅₀s of 9.6, 6.1, and 5.9, respectively.

HY-121166

Levobetaxolol (S)-betaxolol	Adrenergic Receptor	Others
Levobetaxolol is a potent and high affinity *β-adrenergic* antagonist with IC₅₀ values of 33.2, 2970, 709 nM for guinea pig atrial β1, tracheal β2 and rat colonic β3 receptors, respectively. Levobetaxolol reduces IOP (intraocular pressure). Levobetaxolol exhibits a micromolar affinity for L-type Ca21-channels. Levobetaxolol decreases the effects of ischaemia/reperfusion injury in rats. Levobetaxolol has the potential for the research of glaucoma.

HY-144388

ChE/Aβ1-42-IN-1	Cholinesterase (ChE) Amyloid-β	Neurological Disease
ChE/Aβ1-42-IN-1 (compound 28) is a potent ChE and Aβ_1-42 aggregation inhibitor with IC₅₀s of 0.062, 0.767 and 1.227 µM for AChE, BuChE and Aβ_1-42 aggregation, respectively. ChE/β1-42-IN-1 shows excellent BBB penetration. ChE/Aβ1-42-IN-1 is a potent multi-targeted anti-Alzheimer's agent.

HY-146564

R-HP210	NF-κB	Inflammation/Immunology
R-HP210 acts on the NF-κB mediated tethered transrepression function (IC₅₀=3.80 μM). R-HP210 represses the LPS-induced transcription of a variety of proinflammatory genes such as IL-1β, IL-6 and COX-2. R-HP210 does not induce the transactivation functions of Glucocorticoids (GCs).

HY-B0203B

(Rac)-Nebivolol (Rac)-R 065824	Adrenergic Receptor NADPH Oxidase	Cardiovascular Disease
(Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC₅₀ value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity.

HY-143313

*Protease-Activated* Receptor-1 antagonist 1**	Protease Activated Receptor (PAR)	Cardiovascular Disease
Protease-Activated Receptor-1 antagonist 1 (Compound 13) is a protease-activated receptor-1 (PAR-1) antagonist with the IC₅₀ of 3 nM by FLIPR technology. Protease-Activated Receptor-1 antagonist 1 can be used for the research of thrombotic cardiovascular, myocardial infarction, and peripheral arterial disease.

HY-143314

*Protease-Activated* Receptor-1 antagonist 2**	Protease Activated Receptor (PAR)	Cardiovascular Disease
Protease-Activated Receptor-1 antagonist 2 is an orally active protease-activated receptor-1 (PAR-1) antagonist, with an IC₅₀ value of 7 nM. Protease-Activated Receptor-1 antagonist 2 has favorable pharmacokinetic properties which is useful in the research of cardiovascular disease (CVD), such as atherosclerosis and restenosis.

HY-100634

4-Hydroxypropranolol hydrochloride (±)-4-hydroxy Propranolol hydrochloride	Adrenergic Receptor	Neurological Disease
4-Hydroxypropranolol hydrochlorid is an active metabolite of Propranolol. 4-Hydroxypropranolol hydrochlorid is of comparable potency to Propranolol. 4-Hydroxypropranolol hydrochlorid inhibits β1- and β2-adrenergic receptors with pA₂ values of 8.24 and 8.26, respectively. 4-Hydroxypropranolol hydrochlorid has intrinsic sympathomimetic activity, membrane stabilizing activity and potent antioxidant properties.

HY-B0240

Disulfiram Tetraethylthiuram disulfide; TETD	Aldehyde Dehydrogenase (ALDH) Interleukin Related Pyroptosis Apoptosis	Metabolic Disease Cancer
Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells. Disulfiram + Cu²⁺ increases intracellular ROS levels triggering apoptosis of ovarian cancer stem cells^[1-6].

HY-15509A

Semapimod tetrahydrochloride CNI-1493; CPSI-2364 tetrahydrochloride	TNF Receptor Interleukin Related p38 MAPK	Inflammation/Immunology
Semapimod tetrahydrochloride (CNI-1493), an inhibitor of proinflammatory cytokine production, can inhibit TNF-α, *IL-1β, and IL-6. Semapimod tetrahydrochloride inhibits TLR4 signaling (IC₅₀≈0.3 μM). Semapimod tetrahydrochloride inhibits p38 MAPK* and nitric oxide production in macrophages. Semapimod tetrahydrochloride has potential in a variety of inflammatory and autoimmune disorders.

HY-N6018

Beta-Eudesmol	TRP Channel	Metabolic Disease
Beta-Eudesmol is a natural oxygenated sesquiterpene, activates *hTRPA1, with an EC₅₀* of 32.5 μM. Beta-Eudesmol increases appetite through TRPA1.

HY-115669

Pentachloropseudilin Antibiotic A 15104 Y; PClP	Myosin TGF-β Receptor	Cancer
Pentachloropseudilin (Antibiotic A 15104 Y; PClP) is a reversible and allosteric potent inhibitor of *Myo1s* (class 1 myosins) with IC₅₀s range from 1 to 5 μM for mammalian class-1 myosins and greater than 90 μM for class-2 and class-5 myosins. Pentachloropseudilin is a potent inhibitor of transforming growth factor-β *(TGF-β)*-stimulated signaling, with an IC₅₀ of 0.1 to 0.2 μM for TGF-β.

HY-120087

KG-548	HIF/HIF Prolyl-Hydroxylase	Cancer
KG-548 is an ARNT/TACC3 disruptor and a *HIF-1α* inhibitor. KG-548 directly interferes with ARNT/TACC3 complex formation by competing with TACC3 for binding to the ARNT PAS-B domain. ARNT is the aryl hydrocarbon receptor nuclear translocator, also known as *HIF-β*.

HY-130437

p-nitro-Pifithrin-α	MDM-2/p53 TGF-β Receptor Caspase	Infection Metabolic Disease
p-nitro-Pifithrin-α, a cell-permeable analog of pifithrin-α, is a potent p53 inhibitor. p-nitro-Pifithrin-α suppresses p53-mediated *TGF-β1* expression in HK-2 cells. p-nitro-Pifithrin-α inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice fed a high-fat diet [4]. non-alcoholic fatty liver disease.

HY-146483

Anti-Aβ agent 1A	Amyloid-β	Inflammation/Immunology Neurological Disease
Anti-Aβ agent 1A (compound M15) has potent activity against *amyloid-β. Anti-Aβ agent 1A possesses can significantly inhibit LPS-induced levels of IL-1β, IL-6 and TNF-α, and reduces the apoptosis of SH-SY5Y* induced by H₂O₂ through mitochondria pathway. Anti-Aβ agent 1A possesses antioxidant, anti-inflammatory, anti-Aβ toxicity and neuroprotective activities. Anti-Aβ agent 1A can be used for researching Alzheimer’s disease (AD).

HY-131997

2'MeO6MF	GABA Receptor	Inflammation/Immunology Neurological Disease
2'MeO6MF is a brain-penetrant positive allosteric modulator at *α2β1γ2L* and all α1-containing GABA_A receptors. 2'MeO6MF also can directly activate *α2β2/3* and α2β2/3γ2L GABA_A receptors. 2'MeO6MF has anxiolytic and psychomotor stabilizing properties. 2'MeO6MF offers neuroprotection and improved functional recovery and dampens the stroke-induced inflammatory response.

HY-111379

EHT 5372	DYRK CDK GSK-3	Cancer Metabolic Disease Neurological Disease
EHT 5372 is a highly potent and selective inhibitor of DYRK’s family kinases with IC₅₀s of 0.22, 0.28, 10.8, 93.2, 22.8, 88.8, 59.0, 7.44, 221 nM for *DYRK1A, DYRK1B* , DYRK2， DYRK3， CLK1, CLK2, CLK4, GSK-3α, GSK-3β.

HY-146561

S-HP210	Glucocorticoid Receptor NF-κB	Inflammation/Immunology
S-HP210 is a potent and selective glucocorticoid receptor (GR) with an IC₅₀ value of 1.92 μM for NF-κB transrepression (TR). S-HP210 represses the LPS-induced transcription of a variety of proinflammatory genes such as IL-1β, IL-6 and COX-2. S-HP210 is nontoxic at effective doses against mouse fibroblasts 3T3 cells.

HY-147660

IMMH001	LPL Receptor	Inflammation/Immunology
IMMH001, also called SYL930, is an orally active, potent and selective *S1P1* (sphingosine-1-phosphate receptor 1) agonist. IMMH001 decreased levels of both chemokines and proinflammatory cytokines, including IL-1β, IL-5, IL-18, IP10, CCL3, and CCL5. IMMH001 can be used for rheumatoid arthritis (RA) research.

HY-P99111

Golimumab CNTO-148	TNF Receptor Apoptosis Interleukin Related Caspase	Cancer Inflammation/Immunology
Golimumab (CNTO-148) is a potent human IgG1 TNFα antagonist monoclonal antibody. Golimumab has anti-inflammation activitity and inhibits IL-6 and IL-1β production. Golimumab acts via targeting and neutralizing TNF to prevent inflammation and destruction of cartilage and bone. Golimumab has the anticancer activity and induces cell apoptosis. Golimumab can be used for rheumatoid arthritis, Crohn's disease and cancer research.

HY-P1308

SLIGRL-NH2 Protease-Activated Receptor-2 Activating Peptide	Protease Activated Receptor (PAR)	Inflammation/Immunology
SLIGRL-NH2 (Protease-Activated Receptor-2 Activating Peptide) is an agonist of Protease-Activated Receptor-2 (PAR-2).

HY-151520

Wnt/β-catenin agonist 4
Wnt Cancer

Wnt/β-catenin agonist 4 (Derivative 83) is an agonist of Wnt that activates Wnt/β-catenin signal transmission.

HY-110112

BTT-3033	Integrin Apoptosis	Cancer Inflammation/Immunology Cardiovascular Disease
BTT-3033 is an orally active conformation-selective inhibitor of *α2β1* (EC50: 130 nM) by binding to the α2I domain. BTT-3033 inhibits platelet binding to collagen Ⅰ and cell proliferation, and induces cell apoptosis. BTT-3033 can be used in the research of prostate cancer, inflammation and cardiovascular disease.

HY-106345

ILS-920	FKBP Calcium Channel	Inflammation/Immunology Neurological Disease
ILS-920 is a nonimmunosuppressive Rapamycin analog with reduced immunosuppressive activity and potent neuroprotective activity. ILS-920 binds selectively to the immunophilin FKBP52 and to the β1-subunit of L-type voltage-gated calcium channels (VGCC). ILS-920 shows 200-fold selectivity for FKBP52 versus FKBP12.

HY-12274

ML347 LDN 193719	TGF-β Receptor	Cancer
ML347 (LDN193719) is a highly selective *ALK1/ALK2* inhibitor. ML347 has IC₅₀ values of 46 and 32 nM against ALK1 and ALK2, respectively, >300-fold selective over ALK3. ML347 block the phosphorylation of Smad1/5 by TGF-β1.

HY-P2518

*Protease-Activated* Receptor-1, PAR-1 Agonist**	Protease Activated Receptor (PAR)	Inflammation/Immunology
Protease-Activated Receptor-1, PAR-1 Agonist is a selective proteinase-activated receptor1 *(PAR-1)* agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist corresponds to PAR1 tethered ligand and which can selectively mimic theactions of thrombin via this receptor.

HY-B1562C

Bopindolol fumarate (±)-Bopindolol fumarate	Adrenergic Receptor Renin 5-HT Receptor	Neurological Disease Cardiovascular Disease
Bopindolol ((±)-Bopindolol) fumarate is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol fumarate is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol fumarate has intrinsic sympathomimetic as well as membrane stabilizing actions, inhibits renin secretion, and interacts with 5-HT receptors. Bopindolol fumarate is a prodrug of Pindolol (HY-B0982). Bopindolol fumarate can be used for essential and renovascular hypertension research.

HY-B1562

Bopindolol (±)-Bopindolol	Adrenergic Receptor Renin 5-HT Receptor	Neurological Disease Cardiovascular Disease
Bopindolol ((±)-Bopindolol) is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol has intrinsic sympathomimetic as well as membrane stabilizing actions, inhibits renin secretion, and interacts with 5-HT receptors. Bopindolol is a prodrug of Pindolol (HY-B0982). Bopindolol can be used for essential and renovascular hypertension research.

HY-B0573BS

Propranolol-d7	Adrenergic Receptor	Neurological Disease Cardiovascular Disease Endocrinology
Propranolol-d7 is the deuterium labeled Propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with K_i values of 1.8 nM and 0.8 nM, respectively. Propranolol inhibits [³H]-DHA binding to rat brain membrane preparation with an IC₅₀ of 12 nM. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy.

HY-B0573S

Propranolol-d7 hydrochloride	Adrenergic Receptor	Endocrinology Neurological Disease Cardiovascular Disease
Propranolol D7 hydrochloride is a deuterium labeled Propranolol hydrochloride. Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with K_i values of 1.8 nM and 0.8 nM, respectively. Propranolol hydrochloride inhibits [³H]-DHA binding to rat brain membrane preparation with an IC₅₀ of 12 nM. Propranolol hydrochloride is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy.

HY-105670

PHA-543613	nAChR	Neurological Disease
PHA-543613 is a potent, orally active, brain-penetrant and selective α7 nAChR agonist with a K_i of 8.8 nM. PHA-543613 displays selectivity for α7-nAChR over α3β4, α1β1γδ, α4β2 and 5-HT3 receptors. PHA-543613 can be used for the cognitive deficits of Alzheimer's disease and schizophrenia research.

HY-B1803A

Tracazolate hydrochloride ICI 136753 hydrochloride	GABA Receptor	Neurological Disease
Tracazolate (ICI 136753) hydrochloride is a potent GABA_A receptor modulator. Tracazolate hydrochloride has selectivity for β3 and potentiates α1β1γ2s (EC₅₀=13.2 μM), α1β3γ2 (EC₅₀=1.5 μM). Tracazolate hydrochloride has the potency (EC₅₀) determined by the nature of the third subunit (γ1-3, δ, ε) within the receptor complex. Tracazolate hydrochloride possesses anxiolytic and anticonvulsant activity.

HY-113402A

Gamma-glutamylcysteine TFA γ-Glutamylcysteine TFA	Interleukin Related TNF Receptor Endogenous Metabolite	Inflammation/Immunology
Gamma-glutamylcysteine (γ-Glutamylcysteine) TFA, an intermediate in glutathione (GSH) synthesis, is a dipeptide served as an essential cofactor for the antioxidant enzyme glutathione peroxidase (GPx). Gamma-glutamylcysteine TFA also upregulates the level of the anti-inflammatory cytokine IL-10 and reduces the levels of the pro-inflammatory cytokines (TNF-α, IL-6, and *IL-1β). Gamma-glutamylcysteine TFA attenuates the changes in metalloproteinase activity in oligomeric Aβ40-treated astrocytes.*

HY-105670B

PHA-543613 dihydrochloride	nAChR	Neurological Disease
PHA-543613 dihydrochloride is a potent, orally active, brain-penetrant and selective α7 nAChR agonist with a K_i value of 8.8 nM. PHA-543613 dihydrochloride displays selectivity for α7-nAChR over α3β4, α1β1γδ, α4β2 and 5-HT3 receptors. PHA-543613 dihydrochloride can be used for the cognitive deficits of Alzheimer's disease and schizophrenia research.

HY-143315

*Protease-Activated* Receptor-1 antagonist 3**	Protease Activated Receptor (PAR)	Cardiovascular Disease
Protease-Activated Receptor-1 antagonist 3 is a potent protease-activated receptor-1 antagonist with an IC₅₀ value of 7 nM. Protease-Activated Receptor-1 antagonist 3 shows binding affinity for hERG K⁺ channel with an IC₅₀ value of 9 µM.

HY-P3513

β-Neo-Endorphin	ERK MMP	Neurological Disease
β-Neo-Endorphin is an endogenous opioid peptide. β-Neo-Endorphin is a hypothalamic “big” Leu-enkephalin of porcine origin. β-Neo-Endorphin shows activation of the *Erk1/2, MMP-2* and *MMP-9*.

HY-13205

Belnacasan VX-765	Caspase	Inflammation/Immunology
Belnacasan (VX-765) is an orally bioactive prodrug of VRT-043198, which is a potent and selective inhibitor of IL-converting enzyme (ICE)/caspase-1 with K_is of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively. Belnacasan (VX-765) inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC₅₀ of ~0.7 μM.

HY-123857

JNJ-55308942	P2X Receptor	Inflammation/Immunology Neurological Disease
JNJ-55308942 is a high-affinity, selective, brain-penetrant P2X7 functional antagonist (hP2X7: IC₅₀=10 nM, *K_i*=7.1 nM; rP2X7: IC₅₀=15 nM, K_i=2.9 nM). JNJ-55308942 is orally bioavailable, binds to brain P2X7 and blocks IL-1β release from adult rodent brain.

HY-B2205

Magnesium silicate Activated magnesium silicate	Fungal	Infection Inflammation/Immunology
Magnesium silicate (Activated magnesium silicate) is a compound of magnesium oxide (MgO) and silicon dioxide (SiO2). Magnesium silicate is used in antiacid and antiulcer preparation, and as a deodorizer, decolorizer and antifungal.

HY-B1562B

Bopindolol (malonate) (±)-Bopindolol (malonate)	Adrenergic Receptor Renin 5-HT Receptor	Neurological Disease Cardiovascular Disease
Bopindolol ((±)-Bopindolol) malonate is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol malonate is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol malonate has intrinsic sympathomimetic as well as membrane stabilizing actions, inhibits renin secretion, and interacts with 5-HT receptors. Bopindolol malonate is a prodrug of Pindolol (HY-B0982). Bopindolol malonate can be used for essential and renovascular hypertension research.

HY-133987

AP-1/NF-κB activation inhibitor 1	NF-κB	Inflammation/Immunology
AP-1/NF-κB activation inhibitor 1 is a potent *AP-1* and NF-κB mediated transcriptional activation inhibitor (IC₅₀=1 μM), without blocking basal transcription driven by the β-actin promoter. AP-1/NF-κB activation inhibitor 1 has a similar inhibitory effect on the production of IL-2 and IL-8 levels in stimulated cells.

HY-P2518A

*Protease-Activated* Receptor-1, PAR-1 Agonist TFA**	Protease Activated Receptor (PAR)	Cancer
Protease-Activated Receptor-1, PAR-1 Agonist TFA is a selective proteinase-activated receptor1 *(PAR-1)* agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist TFA corresponds to PAR1 tethered ligand and which can selectively mimic theactions of thrombin via this receptor.

HY-B0573S1

Propranolol-d7 (ring-d7)	Adrenergic Receptor	Neurological Disease Endocrinology
Propranolol-d7 (ring-d7) is the deuterium labeled Propranolol hydrochloride. Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with K_i values of 1.8 nM and 0.8 nM, respectively. Propranolol hydrochloride inhibits [³H]-DHA binding to rat brain membrane preparation with an IC₅₀ of 12 nM. Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy.

HY-P2519

*Protease-Activated* Receptor-3 (PAR-3) (1-6), human**	Protease Activated Receptor (PAR)	Inflammation/Immunology
Protease-Activated Receptor-3 (PAR-3) (1-6), human is a proteinase-activated receptor (PAR-3) agonist peptide.

HY-18766

EW-7195	TGF-β Receptor p38 MAPK	Cancer
EW-7195 is a potent and selective ALK5 (TGFβR1) inhibitor with an IC₅₀ of 4.83 nM. EW-7195 has >300-fold selectivity for ALK5 over p38α. EW-7195 efficiently inhibits TGF-β1-induced Smad signaling, epithelial-to-mesenchymal transition (EMT) and breast tumour metastasis to the lung.

HY-P1308A

SLIGRL-NH2 TFA Protease-Activated Receptor-2 Activating Peptide TFA	Protease Activated Receptor (PAR)	Inflammation/Immunology
SLIGRL-NH2 TFA (Protease-Activated Receptor-2 Activating Peptide TFA) is an agonist of Protease-Activated Receptor-2 (PAR-2).

HY-110266

GN44028	HIF/HIF Prolyl-Hydroxylase	Cancer
GN44028 is a potent and orally active hypoxia inducible factor (HIF)-1α inhibitor, with an IC₅₀ of 14 nM. GN44028 inhibits hypoxia-induced HIF-1α transcriptional activity without suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization. GN44028 can be used in the research of cancers.

HY-144737

Anti-inflammatory agent 15	Bacterial TNF Receptor	Infection Inflammation/Immunology
Anti-inflammatory agent 15 (compound 29) is a potent antimycobacterial and anti-inflammatory agent. Anti-inflammatory agent 15 inhibits Mtb H37Rv and M299 growth, with MIC₅₀ (minimum inhibitory concentration 50%) of 2.3 and 7.8 μM, respectively. Anti-inflammatory agent 15 inhibits NO through the suppression of iNOS expression, and also inhibited the production of TNF-α and IL-1β. Anti-inflammatory agent 15 can be used for tuberculosis (TB) research.

HY-100634S

4-Hydroxypropranolol-d7 hydrochloride (±)-4-Hydroxy Propranolol-d7 hydrochloride	Adrenergic Receptor	Neurological Disease
4-Hydroxypropranolol D7 hydrochloride ((±)-4-hydroxy Propranolol D7 hydrochloride) is a deuterium labeled 4-Hydroxypropranolol hydrochloride. 4-Hydroxypropranolol hydrochlorid is an active metabolite of Propranolol, with potency comparable to Propranolol. 4-Hydroxypropranolol hydrochlorid inhibits β1- and β2-adrenergic receptors with pA₂ values of 8.24 and 8.26, respectively. 4-Hydroxypropranolol hydrochlorid has intrinsic sympathomimetic activity, membrane stabilizing activity and potent antioxidant properties.

HY-144727

Anti-inflammatory agent 11	Bacterial TNF Receptor	Infection Inflammation/Immunology
Anti-inflammatory agent 11 (compound 16) is a potent antimycobacterial and anti-inflammatory agent. Anti-inflammatory agent 11 inhibits Mtb H37Rv and M299 growth, with MIC₅₀ (minimum inhibitory concentration 50%) of 1.3 and 6.9 μM, respectively. Anti-inflammatory agent 11 inhibits NO through the suppression of iNOS expression, and also inhibited the production of TNF-α and IL-1β. Anti-inflammatory agent 11 can be used for tuberculosis (TB) research.

HY-N2187

Deoxyshikonin	Bacterial HIF/HIF Prolyl-Hydroxylase	Cancer Infection Cardiovascular Disease
Deoxyshikonin is isolated from Arnebia euchroma with antitumor activity. Deoxyshikonin increases the expression of VEGF-C and VEGF-A mRNA in HMVEC-dLy, promotes HIF-1α and HIF-1β subunit interaction and binds to specific DNA sequences targeted by HIF, indicates a prolymphangiogenesis as well as a proangiogenesis effect in vitro. Deoxyshikonin shows significant synergic antimicrobial activity against S. pneumonia (MIC=17 μg/mL), also shows significantly inhibitory activities against MRSA.

HY-123489

3α,21-Dihydroxy-5α-pregnan-20-one THDOC	GABA Receptor	Neurological Disease
3α,21-Dihydroxy-5α-pregnan-20-one (THDOC), an endogenous neurosteroid, is a positive modulator of GABA_A receptors. 3α,21-Dihydroxy-5α-pregnan-20-one potentiates neuronal response to low concentrations of GABA at α4β1δ GABA_A receptors in vitro.

HY-P1376

G-Protein antagonist peptide	mAChR Adrenergic Receptor	Endocrinology
G-Protein antagonist peptide is the substance P-related peptide that inhibits binding of G proteins to their receptors. G-Protein antagonist peptide competitively and reversibly inhibits M2 muscarinic receptor activation of G_i or G_o and inhibits G_s activation by β-adrenoceptors.

HY-N1533

28-O-β-D-Glucopyranosyl pomolic acid
PAI-1 Inflammation/Immunology

28-O-β-D-Glucopyranosyl pomolic acid is a urokinase plasminogen activator inhibitor with IC₅₀ at 37.82 μM.

HY-P2519A

*Protease-Activated* Receptor-3 (PAR-3) (1-6), human TFA**	Protease Activated Receptor (PAR)	Inflammation/Immunology
Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA is a proteinase-activated receptor (PAR-3) agonist peptide.

HY-141873

Wnt/β-catenin agonist 2	β-catenin	Others
Wnt/β-catenin agonist 2 is a potent Wnt agonist. Wnt/β-catenin agonist 2 activates Wnt/β-catenin signaling and can be used in the research of diseases related to the signal transduction. (From patent WO2007078113A1, compound 39)

HY-N2056

*11-Keto-beta-boswellic acid* 11-Keto-β-boswellic acid	Lipoxygenase Leukotriene Receptor NF-κB	Cancer
11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production.

HY-N9398

3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol	Sirtuin	Cancer
3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol, a *SIRT1* activator, exhibits significant stimulation of SIRT1 activity. Anti-tumor activity.

HY-10255AS

Sunitinib-d10 SU 11248-d10	VEGFR PDGFR IRE1 Mitophagy Autophagy Apoptosis	Cancer
Sunitinib D10 (SU 11248 D10) is a deuterium labeled Sunitinib. Sunitinib is a multi-targeted receptor tyrosine kinase inhibitor with IC₅₀s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively. Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of *Ire1α* by inhibiting autophosphorylation and consequent RNase activation.

HY-118528A

TP0427736 hydrochloride	TGF-β Receptor	Endocrinology
TP0427736 hydrochloride is a potent inhibitor of *ALK5* kinase activity with an IC₅₀ of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC₅₀=836 nM). TP0427736 hydrochloride also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC₅₀ value of 8.68 nM. TP0427736 hydrochloride can be used for the research of androgenic alopecia (AGA).

HY-124745

KY-05009	MAP4K Wnt Apoptosis	Cancer
KY-05009 is an ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor with a K_i of 100 nM. KY-05009 pharmacologically inhibits TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells. KY-05009 inhibits the protein expression of TNIK and transcriptional activity of Wnt target genes and induces apoptosis in cancer cells. KY-05009 exerts anti-cancer activity.

HY-N0892

AKBA Acetyl-11-keto-β-boswellic acid	HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species Endogenous Metabolite	Cancer
AKBA (Acetyl-11-keto-β-boswellic acid) is an active triterpenoid compound from the extract of Boswellia serrate and a novel Nrf2 activator.

HY-148313

PKM2 activator 4
Pyruvate Kinase Cancer

PKM2 activator 4 is a PKM2 activator with an AC₅₀ value of 1-10 μM. PKM2 activator 4 can be used for the research of cancer.

HY-110133

JTE-607	Interleukin Related	Inflammation/Immunology
JTE-607, a highly selective inflammatory cytokine synthesis inhibitor, protects from endotoxin shock in mice. JTE-607 inhibits inflammatory cytokine production, including TNF-α, *IL-1β, IL-6, IL-8* and IL-10, from LPS-stimulated human PBMCs, with IC₅₀s of 11, 5.9, 8.8, 7.3 and 9.1 nM, respectively. Cleavage and Polyadenylation Specificity Factor 3 (CPSF3) is the target of JTE-607.

HY-N5112

(Rac)-Arnebin 1 (Rac)-β,β-Dimethylacrylalkannin; (Rac)-β,β-Dimethylacrylshikonin	HIF/HIF Prolyl-Hydroxylase	Others
(Rac)-Arnebin 1 ((Rac)-β,β-Dimethylacrylalkannin) is the racemate of β,β-Dimethylacrylalkannin and/or β,β-Dimethylacrylshikonin. β,β-Dimethylacrylalkannin and β,β-Dimethylacrylshikonin are napthoquinones isolated from Arnebia nobilis. β,β-Dimethylacrylshikonin has anti-tumor activity.

HY-100634SA

4-Hydroxypropranolol-d7 (±)-4-Hydroxy Propranolol-d7	Adrenergic Receptor	Neurological Disease
4-Hydroxypropranolol-d7 ((±)-4-Hydroxy Propranolol-d7) is the deuterium labeled 4-Hydroxypropranolol hydrochloride. 4-Hydroxypropranolol hydrochlorid is an active metabolite of Propranolol. 4-Hydroxypropranolol hydrochlorid is of comparable potency to Propranolol. 4-Hydroxypropranolol hydrochlorid inhibits β1- and β2-adrenergic receptors with pA₂ values of 8.24 and 8.26, respectively. 4-Hydroxypropranolol hydrochlorid has intrinsic sympathomimetic activity, membrane stabilizing activity and potent antioxidant properties.

HY-19744

T6167923	MyD88	Inflammation/Immunology
T6167923 is a selective inhibitor of MyD88-dependent signaling pathways. T6167923 directly binds to Toll/IL1 receptor (TIR) domain of MyD88 and disrupts MyD88 homodimeric formation. T6167923 inhibits NF-κB driven Staphylococcus enterotoxin AP (SEAP) activity, and improves anti-inflammatory activity with IC₅₀s of 2.7 μM, 2.9 μM, 2.66 μM and 2.66 μM for IFN-γ, IL-1β, IL-6 and TNF-α, respectively.

HY-P1328

TAT-14	Keap1-Nrf2	Others
TAT-14 is a 14-mer peptide that acts as Nrf2* activator* with an anti-inflammatory effect. TAT-14 has no effect on Nrf2 mRNA expression, but increases Nrf2 protein level due to targeting the Nrf2 binding site on Keap1.

HY-13453

BAY 11-7082 BAY 11-7821	IKK Deubiquitinase Autophagy Apoptosis NF-κB	Cancer Inflammation/Immunology
BAY 11-7082 is an IκBα phosphorylation and NF-κB inhibitor. BAY 11-7082 selectively and irreversibly inhibits the TNF-α-induced phosphorylation of IκB-α, and decreases NF-κB and expression of adhesion molecules. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC₅₀=0.19, 0.96 μM, respectively). BAY 11-7082 inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells.

HY-107324

β-Elemene (-)-β-Elemene; Levo-β-elemene	Apoptosis	Cancer
β-Elemene ((-)-β-Elemene; Levo-β-elemene) is isolated from natural plant Curcuma aromatica with an antitumor activity. β-Elemene can induce cell apoptosis.

HY-146066

α7 nAchR-JAK2-STAT3 agonist 1	nAChR JAK STAT NO Synthase	Inflammation/Immunology
α7 nAchR-JAK2-STAT3 agonist 1 is a potent α7 nAchR-JAK2-STAT3 agonist, with an IC₅₀ value of 0.32 μM for nitric oxide (NO). α7 nAchR-JAK2-STAT3 agonist 1 effectively suppresses the expression of iNOS, IL-1β, and IL-6 in murine RAW264.7 macrophages. α7 nAchR-JAK2-STAT3 agonist 1 can inhibit LPS-induced NO release, NF-κB activation and cytokine production. α7 nAchR-JAK2-STAT3 can be used for researching sepsis.

HY-69359

Nipecotic acid (±)-β-Homoproline; Hexahydronicotinic acid; 3-Carboxypiperidine	GABA Receptor	Neurological Disease
Nipecotic acid ((±)-β-Homoproline) is a potent inhibitor of neuronal and glial-aminobutyric acid (GABA) uptake in vitro. Nipecotic acid can also directly activate GABA_A-like chloride channels, with an EC₅₀ of approximately 300 μM.

HY-139791

KCNQ2/3 activator-1	Potassium Channel	Cancer
KCNQ2/3 activator-1 is an activator of Kv7.2/Kv7.3 (KCNQ2/3) potassium channel. KCNQ2/3 activator-1 has the potential in relieving pain (the main problem from medical treatment) (extracted from patent WO2021113757A1, compound A).

HY-131096

L-Proline 4-methoxy-β-naphthylamide hydrochloride H-Pro-4MβNA hydrochloride	Others	Cancer
L-Proline 4-methoxy-β-naphthylamide hydrochloride (H-Pro-4MβNA hydrochloride) can be used for Fap-activated anti-tumor compounds preparaction.

HY-B1204S

*Histamine-α,α,β,β-d4 dihydrochloride* Ergamine-α,α,β,β-d4 dihydrochloride	Histamine Receptor Endogenous Metabolite	Neurological Disease Endocrinology Cancer
Histamine-α,α,β,β-d4 (Ergamine-α,α,β,β-d4) dihydrochloride is the deuterium labeled Histamine. Histamine is an organic nitrogenous compound involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter.

HY-P9967

Aducanumab BIIB037	Amyloid-β	Neurological Disease
Aducanumab (BIIB037), a human monoclonal antibody selective for aggregated forms of *amyloid beta* (Aβ)*. Aducanumab shows brain penetration, and can be used for Alzheimer's disease (AD) research.*

HY-N0550

β-Pinene (-)-β-Pinene	Bacterial	Infection
β-Pinene ((-)-β-Pinene), a major component of turpentine, inhibit infectious bronchitis virus (IBV) with an IC₅₀ of 1.32 mM. β-Pinene presents antimicrobial activity.

HY-N2277

3β,7β,15β-Trihydroxy-11-oxo-lanosta-8-en-24→20 lactone	Bacterial	Infection Inflammation/Immunology
3β,7β,15β-Trihydroxy-11-oxo-lanosta-8-en-24→20 lactone is a natural compound that could be isolated from G. lucidum with antimycobacterial activity.

HY-N1601

2β,6β,15α-Trihydroxy-ent-kaur-16-ene 2β,6β,15α-(-)-Kaur-16-ene	Others	Others
2β,6β,15α-Trihydroxy-ent-kaur-16-ene (compound 19) is a compound isolated from the aerial parts of Pteris cretica.

HY-16702

Pifithrin-β
PFT β; Cyclic Pifithrin-α
MDM-2/p53 Cancer

Pifithrin-β (PFT β) is a potent p53 inhibitor with an IC₅₀ of 23 μM.

HY-N2925

β-Amyrone β-Amyron	Fungal COX PPAR	Infection Metabolic Disease Inflammation/Immunology
β-Amyrone (β-Amyron) is a triterpene compound which has anti-inflammatory activity through inhibiting the expression of COX-2. β-Amyrone has antifungal activity , as well as antiviral activity against Chikungunya virus. β-Amyrone also inhibits α-glucosidase and acetylcholinesterase (AChE) activity. β-Amyrone can be used in the research of disease like inflammation, infection, and obesity.

HY-N0941

beta-Mangostin β-Mangostin	Bacterial Parasite Apoptosis	Cancer Infection
beta-Mangostin (β-Mangostin) is a xanthone compound present in Cratoxylum arborescens, with antibacterial and antimalarial activities. beta-Mangostin exhibits antimycobacterial activity against Mycobacterium tuberculosis with an MIC of 6.25 μg/mL. beta-Mangostin possesses in vitro antimalarial activity against Plasmodium falciparum, with an IC₅₀ of 3.00 μg/mL. beta-Mangostin has potent anticancer activity against various cancers (such as hepatocellular carcinoma, leukaemic).

HY-N2920

β-Amyrenonol 11-Oxo-β-amyrin	Cytochrome P450	Cancer Inflammation/Immunology
β-Amyrenonol (11-Oxo-β-amyrin), an oleanolic-type triterpenoid in licorice roots, is a precursor of Glycyrrhetinic acid. β-Amyrenonol has anti-proliferative and anti-inflammatory activities, and β-Amyrenonol could function as the skeleton for the synthesis of many triterpenoids.

HY-N5112B

β,β-Dimethylacrylshikonin Isoarnebin I	HIF/HIF Prolyl-Hydroxylase	Cancer
β,β-Dimethylacrylshikonin (Isoarnebin I) is a naphthoquinone derivative isolated from Lithospermum erythrorhizon Sieb. et Zucc. , promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway.β,β-Dimethylacrylshikonin has anti-tumor activity.

HY-100206

5α-Androstane-3β,5,6β-triol	AMPK	Neurological Disease
5α-Androstane-3β,5,6β-triol is a neuroprotectant. 5α-Androstane-3β,5,6β-triol can remarkably reverse intracellular acidification and alleviate neuronal injury through the inhibition of AMPK signaling. 5α-Androstane-3β,5,6β-triol remarkably reduced the infarct volume and attenuated neurologic impairment in acute ischemic stroke models of middle cerebral artery occlusion in vivo.

HY-130553

β-Spaglumic acid β-NAAG; β-N-Acetylaspartylglutamic acid	Aminopeptidase mGluR	Neurological Disease
β-Spaglumic acid (β-NAAG) is a competitive NAAG peptidase inhibitor (K_i=1 µM) that protects spinal cord neurons from excitotoxicity and hypoxic damage. β-Spaglumic acid is also a selective mGluR3 antagonist (mGluR3 receptor functions to regulate activity-dependent synaptic potentiation in the hippocampus). β-Spaglumic acid can be used in neuroprotection-related studies.

HY-N7364

(E)-β-Farnesene trans-β-Farnesene	Fungal	Cancer Infection
(E)-β-Farnesene (trans-β-Farnesene) is a volatile sesquiterpene hydrocarbon which can be found in Phlomis aurea Decne essential oil. (E)-β-Farnesene can be used as a feeding stimulant for the sand fly Lutzomyia longipalpis.

HY-N9170

Lup-20(29)-ene-3β,11β-diol	Others	Cancer
Lup-20(29)-ene-3β,11β-diol is a natural triterpenoid with anticancer effects. Lup-20(29)-ene-3β,11β-diol exhibits significant cytotoxic activity against HeLa with an IC₅₀ value of 28.5 μM.

HY-108059

β-Cryptoxanthin (3R)-β-Cryptoxanthin	Endogenous Metabolite	Neurological Disease
β-Cryptoxanthin ((3R)-β-Cryptoxanthin), isolated from Satsuma mandarin orange, is an oxygenated carotenoid and a potent antioxidant. β-Cryptoxanthin has an anti-stress effect.

HY-N10364

6β,7β-Epoxyasteriscunolide A	Others	Cancer
6β,7β-Epoxyasteriscunolide A, a sesquiterpenoid, shows cytotoxicity against the HL-60 and MOLT-3 leukemia cell lines, with IC₅₀s range 4.1-5.4 μM.

HY-P1084

β-Pompilidotoxin β-PMTX	Sodium Channel	Neurological Disease
β-Pompilidotoxin (β-PMTX), a wasp venom, can slow sodium channel inactivation and increases steady-state sodium current in cells.

HY-113953

Z-Asp-CH2-DCB	Caspase Apoptosis	Inflammation/Immunology
Z-Asp-CH2-DCB is an irreversible broad spectrum caspase inhibitor. Z-Asp-CH2-DCB also inhibits proteases with caspase-like activity. Z-D-CH2-DCB blocks the production of IL-1β, TNF-α, IL-6, and IFN-γ in staphylococcal enterotoxin B (SEB)-stimulated peripheral blood mononuclear cells (PBMC), and reduces SEB-1-stimulated T-cell proliferation in a dose-dependent manner. Z-Asp-CH2-DCB prevents SU5416-induced septal cell apoptosis and emphysema development.

HY-149010

NXPZ-2	Keap1-Nrf2	Neurological Disease
NXPZ-2 is an orally active *Keap1-Nrf2* protein–protein interaction (PPI) inhibitor with a K_i value of 95 nM, EC₅₀ value of 120 and 170 nM. NXPZ-2 can dose-dependently ameliorate Aβ_[1-42]-Induced cognitive dysfunction, improve brain tissue pathological changes in Alzheimer’s disease (AD) mouse by increasing neuron quantity and function. NXPZ-2 can inhibit oxidative stress by increasing Nrf2 expression levels and promoting its cytoplasm to nuclear translocation, which is helpful for Keap1-Nrf2 PPI inhibitors and AD associated disease research.

HY-P1328A

TAT-14 TFA	Keap1-Nrf2	Others
TAT-14 TFA is a 14-mer peptide that acts as Nrf2* activator* with an anti-inflammatory effect. TAT-14 TFA has no effect on Nrf2 mRNA expression, but increases Nrf2 protein level due to targeting the Nrf2 binding site on Keap1.

HY-N7606

(Rac)-β-Chamigrenic acid
Others Others

(Rac)-β-Chamigrenic acid is a racemate of β-Chamigrenic acid. β-Chamigrenic acid is a sesquiterpenoid isolated from S.chinensis

HY-N2922

β-Amyrin	Amyloid-β	Neurological Disease
β-Amyrin, an ingredient of Celastrus hindsii, blocks amyloid β (Aβ)-induced long-term potentiation (LTP) impairment. β-amyrin is a promising candidate of treatment for AD.

HY-B1837A

β-Cyfluthrin beta-Cyfluthrin	Calcium Channel	Neurological Disease
β-Cyfluthrin (beta-Cyfluthrin) is a type II synthetic pyrethroid and also an active ingredient of many insecticide products used for pestsin agriculture. β-Cyfluthrin is a neurotoxicant and affects calcium concentration in nervous tissue by inhibiting Ca²⁺ ATPase involved in calcium transport.

HY-P1376A

G-Protein antagonist peptide TFA	mAChR Adrenergic Receptor	Endocrinology
G-Protein antagonist peptide TFA is a truncated substance P-related peptide, competes with receptor for G protein binding. G-Protein antagonist peptide TFA inhibits the activation of G_i or G_o by M2 muscarinic cholinergic receptor (M2 mAChR) or of G_s by beta-adrenergic receptor in the reconstituted phospholipid vesicles, assayed by receptor-promoted GTP hydrolysis.

HY-B0141C

Estradiol hemihydrate β-Estradiol hemihydrate; 17β-Estradiol hemihydrate; 17β-Oestradiol hemihydrate	Estrogen Receptor/ERR Endogenous Metabolite Bacterial	Cancer Neurological Disease
Estradiol (β-Estradiol) hemihydrate is a steroid hormone and the major female sex hormone. Estradiol (β-Estradiol) hemihydrate can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol (β-Estradiol) hemihydrate can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering.

HY-125996

NR1H4 activator 1	FXR	Inflammation/Immunology
NR1H4 activator 1 is a potent and selective Famesoid X Receptor (FXR) agonist, extracted from patent WO2018152171A1, example 4. NR1H4 activator 1 shows strong FXR agonistic potency with a EC₅₀ value of 1 nM in a Human FXR (NR1H4) Assay. NR1H4 activator 1 has the potential for treatment of gastrointestinal disease.

HY-P1051

β-Amyloid (12-28) Amyloid β-Protein (12-28)	Amyloid-β	Neurological Disease
β-Amyloid (12-28) (Amyloid β-Protein (12-28)) is a peptide fragment of β-amyloid protein (β1-42). β1-42, a 42 amino acid protein , is the major component of senile plaque cores. β-Amyloid (12-28) shows aggregation properties. β-Amyloid (12-28) has the potential for Alzheimer’s disease research.

HY-P0128

β-Amyloid (25-35) Amyloid beta-peptide (25-35); Aβ25-35; β-Amyloid peptide (25-35)	Amyloid-β	Neurological Disease
β-Amyloid (25-35) (Amyloid beta-peptide (25-35)) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide, has shown neurotoxic activities in cultured cells.

HY-113068

(rel)-β-Tocopherol	Tyrosinase	Metabolic Disease
(rel)-β-Tocopherol is a relative configuration of β-Tocopherol.(±)-β-Tocopherol is a lipid-soluble form of vitamin E with antioxidant activity. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol.

HY-N1035

Urs-12-ene-3β,16β,22α-triol	Others	Others
Urs-12-ene-3β,16β,22α-triol is a terpenoid compound isolated from the ethanol extract of fresh aerial parts of the Patagonian shrub Nardophyllum bryoides.

HY-113349S

5β-Androstan-3β-ol-17-one-d5
Endogenous Metabolite Metabolic Disease

5β-Androstan-3β-ol-17-one-d5 is the deuterium labeled 5β-Androstan-3β-ol-17-one.

HY-B0445A

NAD sodium β-DPN sodium; β-NAD sodium; β-Nicotinamide Adenine Dinucleotide sodium	Endogenous Metabolite	Metabolic Disease
NAD (β-Nicotinamide Adenine Dinucleotide) sodium is an analogue of NAD. NAD sodium can be reduced to β-nicotinamide adenine dinucleotide (NADH) during coupling with reactions which oxidize organic substrates. NAD sodium can be converted to β-nicotinamide adenine dinucleotide (NADH) and passes to the inside of mitochondria that indirectly generates ATP.

HY-144287

Glucokinase activator 3	Glucokinase	Endocrinology
Glucokinase activator 3 is a potent and full Glucokinase (GK) activator with an AC₅₀ of 38 nM. Glucokinase activator 3 has the potential for the research of type 2 diabetes.

HY-100767

Guanylyl Imidodiphosphate trisodium Guanosine 5'-[β,γ-imido]triphosphate trisodium	Adenylate Cyclase	Endocrinology
Guanylyl Imidodiphosphate (Guanosine 5'-[β,γ-imido]triphosphate) trisodium is a non-hydrolysable GTP analogue, an activator of ADP-ribosylation factor (ARF) and a potent stimulator of adenylate cyclase. Imidodiphosphate trisodium can be used in protein synthesis studies.

HY-P1522

β-Amyloid (29-40)
Amyloid beta-protein(29-40)
Amyloid-β Neurological Disease

β-Amyloid (29-40) is a fragment of Amyloid-β peptide.

HY-N5112A

β,β-Dimethylacrylalkannin Arnebin 1	HIF/HIF Prolyl-Hydroxylase	Others
β,β-Dimethylacrylalkannin (Arnebin 1) is a napthoquinone isolated from Alkanna cappadocica , increases collagen and involucrin content in skin cells.

HY-F0004

β-Nicotinamide mononucleotide β-NM; NMN	Endogenous Metabolite	Cancer Neurological Disease
β-nicotinamide mononucleotide (β-NM) is a product of the nicotinamide phosphoribosyltransferase (NAMPT) reaction and a key NAD⁺ intermediate. The pharmacological activities of β-nicotinamide mononucleotide include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity.

HY-121035

7BIO 7-Bromoindirubin-3-Oxime	CDK GSK-3	Neurological Disease
7BIO (7-Bromoindirubin-3-Oxime) is the derivate of indirubin. 7BIO (7-Bromoindirubin-3-Oxime) has inhibitory effects against cyclin-dependent kinase-5 (CDK5) and glycogen synthase kinase-3β (GSK3β). 7BIO (7-Bromoindirubin-3-Oxime) inhibits Aβ oligomer-induced neuroinflammation, synaptic impairments, tau hyper-phosphorylation, activation of astrocytes and microglia, and attenuates Aβ oligomer-induced cognitive impairments in mice^[1].

HY-145390

Nrf2 activator-1	Keap1-Nrf2	Inflammation/Immunology
Nrf2 activator-1 is a potent activator of NF-E2 related factor 2 (Nrf2). Nrf2 activator-1 has the potential for the treatment of COPD and other respiratory diseases, including asthma, Acute Lung Injury (ALI), Acute Respiratory Distress Syndrome (ARDS) and pulmonary fibrosis (extracted from patent WO2018109647A1).

HY-16702A

Pifithrin-β hydrobromide PFT β hydrobromide; Cyclic Pifithrin-α hydrobromide	MDM-2/p53 Ferroptosis	Cancer
Pifithrin-β hydrobromide (PFT β hydrobromide) is a potent p53 inhibitor with an IC₅₀ of 23 μM.

HY-P1046

β-Amyloid (1-15) Amyloid β-Protein (1-15)	Amyloid-β	Neurological Disease
β-Amyloid (1-15) is a fragment of β-Amyloid peptide. Beta-amyloid is a peptide that forms amyloid plaques in the brains of Alzheimer's disease (AD) patients.

HY-P1934A

Cyclo(L-Phe-L-Pro)	Fungal IFNAR Reactive Oxygen Species	Cancer Inflammation/Immunology Infection
Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide. Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation. Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC₅₀ of 24 µM in the DPPH assay.

HY-N10497

Dihydro-β-erythroidine	nAChR	Neurological Disease
Dihydro-β-erythroidine is a a competitive nicotinic receptor antagonist. Dihydro-β-erythroidine blocks the discriminative stimulus properties of nicotine. Dihydro-β-erythroidine inhibits the anxiolytic effect of nicotine induced.

HY-N8090

(3β,7β,12β,20Z)-3,7,12-Trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid	Others	Inflammation/Immunology
(3β,7β,12β,20Z)-3,7,12-Trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid, a lanostane triterpenoids, exhibits obvious NO inhibitory activity on n LPS-induced BV-2 microglia cells with an IC₅₀ of 9.55 uM. (3β,7β,12β,20Z)-3,7,12-Trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid has anti-inflammatory activities.

HY-B0151

Pregnenolone 3β-Hydroxy-5-pregnen-20-one	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels.

HY-P1521

β-Amyloid (15-21)
beta-Amyloid (15-21)
Amyloid-β Neurological Disease

β-amyloid (15-21) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.

HY-P0179

β-Casomorphin, bovine β-Casomorphin-7 (bovine); Bovine β-casomorphin-7	Opioid Receptor	Metabolic Disease Neurological Disease
β-Casomorphin, bovine (β-Casomorphin-7 (bovine) ) is a opioid peptide with an IC₅₀ of 14 μM in an Opioid receptors binding assay.

HY-N2274

23-Hydroxylongispinogenin 12-Oleanene-3β,16β,23,28-tetrol; 3β,16β-12-Oleanene-3, 16,23,28-tetrol	Others	Cancer
23-Hydroxylongispinogenin (12-Oleanene-3β,16β,23,28-tetrol) is extracted from Lysimachia heterogenea Klatt. Lysimachia heterogenea Klatt is a perennial herb, which is used as a folk medicine in subduing swelling and detoxicating in China. The effective fraction LH-1 of L. heterogene has antitumor activity.

HY-125586

β-Amanitin	DNA/RNA Synthesis ADC Cytotoxin	Cancer
β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom. β-Amanitin inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis. β-Amanitin can be used as a cytotoxic component of antibody-drug conjugates (ADCs).

HY-145983

Suc-Gly-Pro-AMC
Others Cancer

Suc-Gly-Pro-AMC is a fibroblast activation protein (FAP)-specific substrate. Suc-Gly-Pro-AMC can be used to study the activity of FAP.

HY-112472

S3969	Sodium Channel	Metabolic Disease
S3969 is a potent and reversible activator of the human epithelial sodium channel (hENaC). The apparent EC₅₀ for S3969 activation of hENaC is 1.2 μm.

HY-P1084A

β-Pompilidotoxin TFA β-PMTX TFA	Sodium Channel	Neurological Disease
β-Pompilidotoxin TFA (β-PMTX TFA), a wasp venom, can slow sodium channel inactivation and increases steady-state sodium current in cells.

HY-N6575

7β-Hydroxybufalin	Glucosidase Cholinesterase (ChE)	Metabolic Disease
7β-Hydroxybufalin is a bufadienolide. 7β-Hydroxybufalin can be isolated from the venom of Bufo bufo gargarizans. 7β-Hydroxybufalin inhibits α-glucosidase and *acetylcholinesterase*.

HY-P1051A

β-Amyloid (12-28) (TFA) Amyloid β-Protein (12-28) (TFA); Amyloid beta-Peptide (12-28) (human) TFA; β-Amyloid protein fragment(12-28) TFA	Amyloid-β	Neurological Disease
β-Amyloid (12-28) (TFA) (Amyloid β-Protein (12-28) (TFA)) is a peptide fragment of β-amyloid protein (β1-42). β1-42, a 42 amino acid protein , is the major component of senile plaque cores. β-Amyloid (12-28) (TFA) shows aggregation properties. β-Amyloid (12-28) (TFA) has the potential for Alzheimer’s disease research.

HY-N1968

*Quercetin-3-O-β-D-glucose-7-O-β-D-gentiobiosiden* Quercetin-3-O-beta-D-glucose-7-O-beta-D-gentiobioside	Others	Others
Quercetin-3-O-β-D-glucose-7-O-β-D-gentiobiosiden is a flavonoid from Quercetin.

HY-121320

Raptinal	Caspase Apoptosis	Cancer
Raptinal, a agent that directly activates caspase-3, initiates intrinsic pathway caspase-dependent apoptosis. Raptinal is able to rapidly induce cancer cell death by directly activating the effector caspase-3, bypassing the activation of initiator caspase-8 and caspase-9.

HY-137824

4-Methylumbelliferyl-β-D-xylopyranoside 4-Methylumbelliferyl-β-D-xyloside	Others	Others
4-Methylumbelliferyl-β-D-xylopyranoside (MuX) can be used as substrate for the research of β-Xylosidase activity. 4-Methylumbelliferyl-β-D-xylopyranoside shows burst, steady-state kinetics, which supports the conclusion that hydrolysis of the glycosidic bonds for the substrate 4-Methylumbelliferyl-β-D-xylopyranoside is rapid.

HY-W127512

5β-Cholanic acid
Others Others

5β-Cholanic acid can be used for 5β-Cholanic acid derivatives synthesis.

HY-N3847

Eriodictyol-7-O-glucoside Eriodictyol 7-O-β-D-glucoside	Keap1-Nrf2	Metabolic Disease
Eriodictyol-7-O-glucoside (Eriodictyol 7-O-β-D-glucoside), a flavonoid, is a potent free radical scavenger. Eriodictyol-7-O-glucoside is also an Nrf2 activator, confers protection against Cisplatin-induced toxicity.

HY-141672

17β-Estradiol sulfate sodium 17β-Estradiol 3-sulfate sodium	GABA Receptor	Neurological Disease
17β-Estradiol sulfate (sodium), also known as β-Estradiol 3-sulfate sodium salt, is a neuroactive steroid.

HY-N5081

1αH,5αH-Guaia-6-ene-4β,10β-diol	Others	Cancer
1αH,5αH-Guaia-6-ene-4β,10β-diol is a sesquiterpenoid derivative identified from Alisma orientale. 1αH,5αH-Guaia-6-ene-4β,10β-diol has anti-cancer activities.

HY-W010231

β-Cyclocitral	Others	Others
β-Cyclocitral, a volatile oxidized derivative of β-carotene, is a grazer defence signal unique to the Cyanobacterium Microcystis. β-Cyclocitral, one of the predominant volatile terpenoid compounds, can upregulate the expression of defence genes to enhance excess light (EL) acclimation. β-Cyclocitral is a powerful repellent.

HY-P1474

β-Amyloid (22-35) Amyloid β-Protein (22-35)	Amyloid-β	Neurological Disease
β-Amyloid 22-35 (Amyloid β-Protein 22-35), the residues 22-35 fragment ofβ-amyloid protein, has a cytotoxic effect on cultured neurons from the rat hippocampus in serum-free medium. β-Amyloid 22-35 forms aggregates and typical amyloid fibrils resembling those of the β-amyloid protein in neutral buffer solution).

HY-P1468

β-Amyloid (1-28) Amyloid β-Protein (1-28)	Amyloid-β	Neurological Disease
β-Amyloid (1-28) is a β-Amyloid protein fragment involved in metal binding. Beta-amyloid is a peptide that forms amyloid plaques in the brains of Alzheimer's disease (AD) patients.

HY-P1466

β-Amyloid (1-16) Amyloid β-Protein (1-16)	Amyloid-β	Neurological Disease
β-Amyloid (1-16) is a β-Amyloid protein fragment involved in metal binding. Beta-amyloid is a peptide that forms amyloid plaques in the brains of Alzheimer's disease (AD) patients.

HY-N6652

1-beta-D-Arabinofuranosyluracil Uracil 1-β-D-arabinofuranoside	Others	Cancer Inflammation/Immunology Cardiovascular Disease
1-beta-D-Arabinofuranosyluracil (Uracil 1-β-D-arabinofuranoside) isolated from the Caribbean sponge Tectitethya crypta, is a methoxyadenosine derivative. 1-beta-D-Arabinofuranosyluracil has demonstrated a diverse bioactivity profile including anti-inflammatory activity, analgesic and vasodilation properties. 1-beta-D-Arabinofuranosyluracil reduces a proliferation of mouse lymphoma cells.

HY-P1481A

β-Casomorphin, human TFA Human β-casomorphin 7 TFA	Opioid Receptor	Metabolic Disease Neurological Disease
β-Casomorphin, human TFA (Human β-casomorphin 7 TFA) is an opioid peptide, acts as an agonist of opioid receptor.

HY-130223

11β-Prostaglandin E2 11β-Dinoprostone; 11β-PGE2	Prostaglandin Receptor	Endocrinology
11β-Prostaglandin E2 (11β-Dinoprostone), a Prostanoid derivative, inhibits [^3H]PGE₂ binding to hypothalamic membranes in the rat with a K_i of 53.3 nM.

HY-114464

*11-Beta-hydroxyandrostenedione* 4-Androsten-11β-ol-3,17-dione	Endogenous Metabolite 11β-HSD	Endocrinology
11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor. As 4-androstenedione increases, measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism.

HY-128976

10β,17β-dihydroxyestra-1,4-dien-3-one DHED	Estrogen Receptor/ERR	Metabolic Disease
10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) is a brain-targeting bioprecursor prodrug of the main human estrogen, 17β-estradiol, alleviates hot flushes in rat models of thermoregulatory dysfunction of the brain.

HY-106029

4α-TPA
α-TPA
Others Cancer

4α-TPA is an inactive form of TPA, and is used as a negative control for TPA-activated events.
HY-113351

11β-Hydroxyandrosterone
Endogenous Metabolite Endocrinology

11β-Hydroxyandrosterone is a 11-oxygenated androgen metabolite of 11β-hydroxyandrostenedione.
HY-125849

Chrysin 7-O-beta-gentiobioside
Chrysin 7-O-β-gentiobioside
Others Cancer

Chrysin 7-O-beta-gentiobioside (Chrysin 7-O-β-gentiobioside) is the glycosylation product of Chrysin.
HY-22306

β-D-Glucose pentaacetate
Penta-O-acetyl-β-D-glucopyranose
Others Others

β-D-Glucose Pentaacetate (Penta-O-acetyl-β-D-glucopyranose) is used in biochemical reaction.

HY-141672S

17β-Estradiol sulfate-d5 sodium 17β-Estradiol 3-sulfate-d5 sodium	GABA Receptor	Neurological Disease
17β-Estradiol sulfate-d5 (17β-Estradiol 3-sulfate-d5) sodium is the deuterium labeled 17β-Estradiol sulfate sodium. 17β-Estradiol sulfate sodium, also known as β-Estradiol 3-sulfate sodium salt, is a neuroactive steroid.

HY-N8573

β-Phellandrene
Others Others

β-Phellandrene is obtained from Carum petroselinum. β-Phellandrene can be used to essential oil additives.
HY-N8549

5β-Dihydrocortisone
Endogenous Metabolite Metabolic Disease

5β-Dihydrocortisone is a sterol metabolite of cortisone by 5β-reductase (AKR1D1) in liver.

HY-N5053

*Periplogenin 3-[O-β-glucopyranosyl-(1→4)-β-sarmentopyranoside]*	Others	Others
Periplogenin 3-[O-β-glucopyranosyl-(1→4)-β-sarmentopyranoside] is a cardenolide isolated from the root barks of Periploca sepium.

HY-136736

β-Secretase Inhibitor II	Beta-secretase	Neurological Disease
β-Secretase Inhibitor II is a *β-Secretase* inhibitor. β-Secretase Inhibitor II is a simple tripeptide aldehyde (IC₅₀=700 nM for inhibition of total Aβ and *IC₅₀*=2.5 μM for Aβ_1–42). β-Secretase Inhibitor II can be used for the research of Alzheimer's disease.

HY-12780S

*6-beta-Naloxol D5 hydrochloride* 6β-Naloxol D5 hydrochloride	Opioid Receptor	Neurological Disease
6-beta-Naloxol D5 hydrochloride is the deuterium labeled 6-beta-Naloxol, which is an opioid antagonist closely related to naloxone.

HY-P2775

β-Glucosidase	Glucosidase	Others
β-Glucosidase is the rate-limiting enzyme of degradation of cellulose. β-Glucosidase is a major group among glycoside hydrolases. β-Glucosidase is involved in the degradation of cellulose in soils and has potential for monitoring biological soil quality.

HY-141672S1

17β-Estradiol sulfate-d4 sodium 17β-Estradiol 3-sulfate-d4 sodium	GABA Receptor
17β-Estradiol sulfate-d4 (sodium) is the deuterium labeled 17β-Estradiol sulfate 17β-Estradiol sulfate (sodium), also known as β-Estradiol 3-sulfate sodium salt, is a neuroactive steroid.

HY-147007

β-catenin-IN-3	β-catenin Wnt	Cancer
β-catenin-IN-3 (compound C2) is a potent and selective *β-catenin* inhibitor with a K_D value of 54.96 nM. β-catenin-IN-3 acts by targeting a cryptic allosteric modulation site of β-catenin. β-catenin-IN-3 can significantly reduce viability of β-catenin-driven cancer cells.

HY-148133

GSK-3β inhibitor 12	GSK-3	Neurological Disease
GSK-3β inhibitor 12 (compound 15) is an inhibitor of *GSK-3β. GSK-3β* inhibitor 12 inhibits 49.11% and 37.11% activity of 25 μM and 50 μM GSK-3β, respectively. GSK-3β inhibitor 12 can be used for the research of neurodegenerative diseases.

HY-P1772

β-Amyloid (1-17)
Amyloid-β Neurological Disease

β-Amyloid (1-17) is a peptide of β-Amyloid, stabilizes the fibres and plays a role in Aβ fibre formation.

HY-N1415S

β-Caryophyllene-d2	Cannabinoid Receptor Endogenous Metabolite	Cancer Infection Neurological Disease
β-Caryophyllene-d2 is deuterium labeled β-Caryophyllene. β-Caryophyllene is a CB2 receptor agonist.

HY-N3995

5β-Dihydrocortisol	Apoptosis Drug Metabolite	Cancer
5β-Dihydrocortisol, a metabolite of Cortisol, is a potential mineralocorticoid. 5β-Dihydrocortisol can potentiate glucocorticoid activity in raising the intraocular pressure. 5β-Dihydrocortisol causes breast cancer cell apoptosis.

HY-N9521

*3-O-β-D-Glucopyranosyl(1→2)-[a-Lrhamnopyranosyl(1→3)]-β-D-glucopyranosyl 28-O-β-D-glucuronopyranoside*	Others	Cancer
3-O-β-D-Glucopyranosyl(1→2)-[a-Lrhamnopyranosyl(1→3)]-β-D-glucopyranosyl 28-O-β-D-glucuronopyranoside, a saponin, is isolated from Polaskia chichipe Backbg. 3-O-β-D-Glucopyranosyl(1→2)-[a-Lrhamnopyranosyl(1→3)]-β-D-glucopyranosyl 28-O-β-D-glucuronopyranoside shows ability to inhibit melanin biosynthesis by B16 melanoma cell with inhibitory activity 84.2% at 100μM[1].

HY-130842

β-Naphthoflavone-CH2-Br β-NF-CH2-Br	Ligands for E3 Ligase	Cancer
β-Naphthoflavone-CH2-Br (β-NF-CH2-Br) is an arylhydrocarbon receptor (AhR) ligand. β-Naphthoflavone-CH2-Br can be used to synthesize the PROTAC β-NF-JQ1(HY-130256).

HY-108693

β-Tocotrienol
Others Inflammation/Immunology

β-Tocotrienol is one form of vitamin E. β-Tocotrienol is a less potent antioxidant than α-tocotrienol.

HY-N8214

*Isorhamnetin 3-O-β-D-glucose-7-O-β-D-gentiobioside*	Others	Cardiovascular Disease
Isorhamnetin 3-O-β-D-glucose-7-O-β-D-gentiobioside is a bioactive constituent that can be found in the seeds of Lepidium apetalum Willd. Isorhamnetin 3-O-β-D-glucose-7-O-β-D-gentiobioside exhibits significant triglyceride (TG)-lowering effects in HepG2 cells.

HY-F0004S

β-Nicotinamide mononucleotide-d4 β-NM-d4; NMN-d4	Endogenous Metabolite	Cancer Neurological Disease
β-Nicotinamide mononucleotide-d4 (β-NM-d4) is the deuterium labeled β-Nicotinamide mononucleotide. β-nicotinamide mononucleotide (β-NM) is a product of the nicotinamide phosphoribosyltransferase (NAMPT) reaction and a key NAD⁺ intermediate. The pharmacological activities of β-nicotinamide mononucleotide include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity.

HY-148132

GSK-3β inhibitor 11	GSK-3	Neurological Disease
GSK-3β inhibitor 11 (compound 21) is a glycogen synthase kinase-3β (GSK-3β) inhibitor (IC₅₀=10.02 μM). GSK-3β inhibitor 11 can be used in neurodegenerative disease research.

HY-W187305

MASM7	Others	Others
MASM7 is a mitofusin activator, and can achieve mitochondrial fusion via mitofusins. MASM7 can increase Mito AR with an EC₅₀ value of 75 nM in MEFs in concentration-responsively, and can promote mitochondrial fusion by directly activating MFN2 or MFN. MASM7 also demonstrates direct binding to the HR2 domain of MFN2 with K_d value of 1.1 μM.

HY-N2454

β-Elemonic acid	Apoptosis Reactive Oxygen Species COX Endogenous Metabolite Prolyl Endopeptidase (PREP)	Cancer Inflammation/Immunology
β-Elemonic acid is a triterpene isolated from Boswellia carterii. β-Elemonic acid induces cell apoptosis, reactive oxygen species (ROS) and COX-2 expression and inhibits prolyl endopeptidase. β-Elemonic acid exhibits anticancer and anti-inflammatory effects.

HY-P0078

TRAP-6 PAR-1 agonist peptide; Thrombin Receptor Activator Peptide 6	Protease Activated Receptor (PAR)	Inflammation/Immunology
TRAP-6 (PAR-1 agonist peptide), a peptide fragment, is a selective protease activating receptor 1 (PAR1) agonist. TRAP-6 activates human platelets via the thrombin receptor. TRAP-6 shows no activity at PAR4.

HY-135386

5β-Dutasteride	Drug Metabolite	Inflammation/Immunology
5β-Dutasteride is the S configuration of Dutasteride. 5β-Dutasteride is a potent inhibitor of both 5 alpha-reductase isozymes.

HY-N3808

(4α,11β,15β)-11,15-Dihydroxykaur-16-en-19-oic acid	Others	Others
(4α,11β,15β)-11,15-Dihydroxykaur-16-en-19-oic acid is a compound isolated from the Tunisian Pulicaria laciniata (Coss.et Kral.) Thell. flowers.

HY-N1033

12-Hydroxyjasmonic acid
(-)-12-Hydroxyjasmonic acid
Others Others

12-Hydroxyjasmonic acidis is a COI1-JAZ-independent activator of leaf-closing movement in Samanea saman.

HY-133680

β-Tocopherol	Tyrosinase	Metabolic Disease
β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol.

HY-W291131

Isatin-β-thiosemicarbazone IBT	HSV Orthopoxvirus	Infection
Isatin-β-thiosemicarbazone is a potent anti-poxvirus agent (including monkeypox virus, orthopoxvirus, vaccinia virus, etc). Isatin-β-thiosemicarbazone also is a potent herpes simplex virus (HSV) inhibitor. Isatin-β-thiosemicarbazone exhibits

HY-114740

β-Naphthoflavone 5,6-Benzoflavone; beta-NF	Aryl Hydrocarbon Receptor Apoptosis	Cancer Neurological Disease
β-Naphthoflavone is a non-carcinogenic AhR agonist as a positive control for the induction of AhR transcriptional activity. β-Naphthoflavone inhibits hydrogen peroxide-induced apoptosis.

HY-130795

GSK-3β inhibitor 2	GSK-3	Neurological Disease
GSK-3β inhibitor 2 (Compound 3) is a potent, selective and orally active *GSK-3β* inhibitor with an IC₅₀ of 1.1 nM. GSK-3β inhibitor 2 can cross the blood-brain barrier. GSK-3β inhibitor 2 has the potential for Alzheimer's disease.

HY-N7682

β-Tomatine
Fungal Others

β-Tomatine is a breakdown product of α-tomatine and a less fungitoxic compound. β-Tomatine can suppress plant defense responses.

HY-125773

β-cyano-L-Alanine beta-cyano-l-alanine	Endogenous Metabolite	Neurological Disease
β-cyano-L-Alanine (Beta-cyano-l-alanine), a nitrile of widespread occurrence in higher plants, is enzymatically produced by cyanoalanine synthase from cyanide and cysteine as substrates. β-cyano-L-Alanine abolishes the protective effect of ethanol on cerebral ischemia/reperfusion (I/R) injury.

HY-12452

DPN Diarylpropionitrile	Estrogen Receptor/ERR Apoptosis Autophagy	Neurological Disease
DPN (Diarylpropionitrile) is a non-steroidal estrogen receptor β (ERβ) selective ligand, with an EC₅₀ of 0.85 nM. DPN has neuroprotective effects in a number of neurological diseases.

HY-P1880

β-Amyloid (12-20)
Amyloid-β Neurological Disease

β-Amyloid (12-20) is a peptide fragment of β-Amyloid.
HY-P1891

β-Amyloid (22-40)
Amyloid-β Neurological Disease

β-Amyloid (22-40) is a peptide fragment of β-Amyloid.
HY-P1879

β-Amyloid (18-28)
Amyloid-β Neurological Disease

β-Amyloid (18-28) is a peptide fragment of β-Amyloid.
HY-P1893

β-Amyloid (11-22)
Amyloid-β Neurological Disease

β-Amyloid (11-22) is a peptide fragment of β-Amyloid.

HY-141480

GSK-3β inhibitor 3	GSK-3 Apoptosis	Cancer
GSK-3β inhibitor 3 is a potent, selective, irreversible and covalent inhibitor of Glycogen Synthase Kinase 3β (GSK-3β), with an IC₅₀ of 6.6 μM. GSK-3β inhibitor 3 can be used for the research of acute promyelocytic leukemia.

HY-P1474A

β-Amyloid (22-35) (TFA) Amyloid β-Protein (22-35) (TFA)	Amyloid-β	Neurological Disease
β-Amyloid 22-35 (Amyloid β-Protein 22-35) TFA, the residues 22-35 fragment ofβ-amyloid protein, has a cytotoxic effect on cultured neurons from the rat hippocampus in serum-free medium. β-Amyloid 22-35 TFA forms aggregates and typical amyloid fibrils resembling those of the β-amyloid protein in neutral buffer solution).

HY-122098

Diaplasinin
PAI-749
PAI-1 Cardiovascular Disease

Diaplasinin (PAI-749) is a plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC₅₀ of 295 nm. Antithrombotic efficacy.

HY-143261

GSK-3β inhibitor 7	GSK-3	Cancer Metabolic Disease Inflammation/Immunology
GSK-3β inhibitor 7 is a *GSK-3β* inhibitor with an IC₅₀ value of 5.25 μM. GSK-3β inhibitor 7 is inserted into the ATP-binding binding pocket of GSK-3β and forms hydrogen-bond. GSK-3β inhibitor 7 shows high hepatocyte glucose uptake (83.5%), and can be used in the research of numerous diseases like diabetes, inflammation, cancer, Alzheimer's disease, and bipolar disorder.

HY-B0141S

Estradiol-d3 β-Estradiol-d3; 17β-Estradiol-d3; 17β-Oestradiol-d3	Estrogen Receptor/ERR Endogenous Metabolite	Endocrinology Cancer
Estradiol-d3 (β-Estradiol-d3) is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.

HY-N3995S

5β-Dihydrocortisol-d6	Apoptosis Drug Metabolite	Cancer
5β-Dihydrocortisol-d6 is the deuterium labeled 5β-Dihydrocortisol. 5β-Dihydrocortisol, a metabolite of Cortisol, is a potential mineralocorticoid. 5β-Dihydrocortisol can potentiate glucocorticoid activity in raising the intraocular pressure. 5β-Dihydrocortisol causes breast cancer cell apoptosis.

HY-P0179A

β-Casomorphin, bovine TFA β-Casomorphin-7 (bovine) (TFA); Bovine β-casomorphin-7 TFA	Opioid Receptor	Metabolic Disease Neurological Disease
β-Casomorphin, bovine TFA (β-Casomorphin-7 (bovine) TFA) is a opioid peptide with an IC₅₀ of 14 μM in an Opioid receptors binding assay.

HY-N7907

*Myricetin-3-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranoside*	Others	Metabolic Disease
Myricetin-3-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranoside is a natural product that can be obtained from sphaerophysa salsula. Myricetin-3-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranoside inhibits triglyceride (TG) accumulation in 3T3-L1 adipocytes.

HY-A0144

Etilefrine	Adrenergic Receptor AMPK	Cardiovascular Disease
Etilefrine (3-[2-(ethylamino)-1-hydroxyethyl]phenol) is an α adrenergic agonist. Etilefrine also is an AMPK activator. Etilefrine can be used for the research of postural hypotension.

HY-135670A

*β-glycosidase-IN-1*	Glucosidase Others	Metabolic Disease
β-glycosidase-IN-1 (Compound 33) is a piperidine derivative and a *β-glycosidase* inhibitor. β-glycosidase-IN-1 has hypoglycemic activity.

HY-114464S1

*11-Beta-hydroxyandrostenedione-d7* 4-Androsten-11β-ol-3,17-dione-d7	Endogenous Metabolite 11β-HSD	Others
11-Beta-hydroxyandrostenedione-d7 is the deuterium labeled 11-Beta-hydroxyandrostenedione. 11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor. As 4-androstenedione increases, measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism.

HY-P1362

β-Amyloid (42-1), human Amyloid β Peptide (42-1)(human)	Amyloid-β	Neurological Disease
β-Amyloid (42-1), human is the inactive form of Amyloid β Peptide (1-42). β-Amyloid (42-1), human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.

HY-114464S

*11-Beta-hydroxyandrostenedione-d4* 4-Androsten-11β-ol-3,17-dione-d4	Endogenous Metabolite 11β-HSD	Endocrinology
11-Beta-hydroxyandrostenedione-d4 (4-Androsten-11β-ol-3,17-dione-d4) is the deuterium labeled 11-Beta-hydroxyandrostenedione. 11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor. As 4-androstenedione increases, measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism.

HY-113068S

β-Tocopherol-d3	Tyrosinase	Metabolic Disease
β-Tocopherol-d3 is the deuterium labeled β-Tocopherol. β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol can also prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol.

HY-N6741

β-Zearalenol	Others	Infection Endocrinology
β-Zearalenol is a non-steroidal estrogenic mycotoxin synthesized by Fusarium species. β-Zearalenol potentially influences transcription and effects gene expression on translational level.

HY-136552

β-Bisabolene	Others	Cancer
β-Bisabolene is a sesquiterpene isolated from opoponax (Commiphora guidotti). β-Bisabolene, an anti-cancer agent, can be used for the study of breast cancer.

HY-147134

GSK-3β inhibitor 10	GSK-3	Neurological Disease
GSK-3β inhibitor 10 (compound 14a) is a highly potent *GSK-3β* inhibitor with an IC₅₀ value of 80.5 nM. GSK-3β inhibitor 10 can be used for researching Alzheimer’s disease.

HY-147946

PDE1-IN-4	Phosphodiesterase (PDE) Calcium Channel	Inflammation/Immunology
PDE1-IN-4 (compound 2g) is a potent and selective *PDE1* (phosphodiesterase-1) inhibitor, with IC₅₀ values of 10, 145, and 354 nM for *PDE1C, PDE1A, and PDE1B, respectively. PDE1-IN-4* inhibits myofibroblast differentiation of human lung fibroblasts induced by TGF-β1. PDE1-IN-4 shows anti-fibrosis effects through the regulation of cAMP (3′,5′-cyclic adenosine monophosphate) and cGMP (3′,5′-cyclic guanosine monophosphate). PDE1-IN-4 can be used for idiopathic pulmonary fibrosis (IPF) research.

HY-P1867

β-Amyloid (1-34)
Amyloid-β Neurological Disease

β-Amyloid (1-34) is a β-Amyloid peptide consists of 34 amino acid.

HY-143260

GSK-3β inhibitor 6	GSK-3	Cancer Metabolic Disease Inflammation/Immunology
GSK-3β inhibitor 6 is a potent *GSK-3β* inhibitor with an IC₅₀ value of 24.4 μM. GSK-3β inhibitor 6 shows high hepatocyte glucose uptake (38%). GSK-3β inhibitor 6 can be used in the research of numerous diseases like diabetes, inflammation, cancer, Alzheimer's disease, and bipolar disorder.

HY-N7635

Oleanolic acid 28-O-β-D-glucopyranoside β-D-Glucopyranosyl oleanolate	Others	Others
Oleanolic acid 28-O-β-D-glucopyranoside (β-D-Glucopyranosyl oleanolate) is a saponin isolated from the roots of Achyranthes bidentata Blume.

HY-B0141S3

Estradiol-d2 β-Estradiol-d2; 17β-Estradiol-d2; 17β-Oestradiol-d2	Estrogen Receptor/ERR Endogenous Metabolite	Endocrinology Cancer
Estradiol-d2 (β-Estradiol-d2) is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.

HY-B0141S1

Estradiol-d4 β-Estradiol-d4; 17β-Estradiol-d4; 17β-Oestradiol-d4	Estrogen Receptor/ERR Endogenous Metabolite	Endocrinology Cancer
Estradiol-d4 (β-Estradiol-d4) is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.

HY-D1460

Fluorescein Di-β-D-Glucuronide	Bacterial	Infection
Fluorescein Di-β-D-Glucuronide, a fluorescent probe, can be utilized to non-invasively image the intestinal bacterial β-glucuronidase activity in nude mice. Fluorescein Di-β-D-Glucuronide-based imaging reveals the in vitro and in vivo activity of intestinal bacterial β-glucuronidase, which would facilitate pharmacodynamic studies of specific bacterial β-glucuronidase inhibitors in animal studies.

HY-136234

9-cis-β-Carotene	Others	Others
9-cis-β-Carotene, a precursor of retinal, is cleaved by beta-carotene oxygenase 1 (BCMO1) to produce 9-cis-retinal. 9-cis-β-Carotene inhibits photoreceptor degeneration and restores retinal function in vivo. 9-cis-β-Carotene has the potential for the study of congenital stationary night blindness and fundus albipunctatus.

HY-113478

3β-Ursodeoxycholic acid Isoursodeoxycholic acid	Others	Metabolic Disease
3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) is a bile acid. 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) shows good tolerance and well intestinal absorption by oral adminstation. 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) can be isomerized by intestinal and hepatic enzymes to yield UDCA.

HY-126144

GSK-3β inhibitor 1	GSK-3	Metabolic Disease
GSK-3β inhibitor 1 (compound 3a) is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy, with an IC₅₀ of 4.9 nM.

HY-141432

Cbl-b-IN-3	E1/E2/E3 Enzyme	Cancer
Cbl-b-IN-3 (Compound 23) is a casitas B-lineage lymphoma proto-oncogene-b (Cbl-b) inhibitor with an IC₅₀ of < 1 nM. Cbl-b is an E3 ubiquitin ligase that negatively regulates T-cell activation.

HY-139553

Zunsemetinib ATI-450; CDD-450	MAPKAPK2 (MK2)	Inflammation/Immunology
Zunsemetinib (CDD-450) is an orally active and selective p38α mitogen-activated protein kinase-activated protein kinase 2 (MK2) pathway inhibitor. Zunsemetinib can be used for the research of immuno-inflammatory diseases.

HY-19345

Vacquinol-1 NSC13316	Others	Cancer
Vacquinol-1 (NSC13316) is a MKK4-specific activator that activates MAPK pathways. Vacquinol-1 specifically induces human glioblastoma cell (GC) death, attenuates tumor progression and prolongs survival in a glioblastoma multiforme (GBM) mouse model. Vacquinol-1 also induces apoptosis in hepatocellular carcinoma (HCC)cell.

HY-N0338

*(-)-Syringaresnol-4-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside*	Others	Others
(-)-Syringaresnol-4-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside is isolated from the bark of Albizia julibrissin.

HY-P1895

β-Amyloid (33-40)
Amyloid-β Neurological Disease

β-Amyloid (33-40) is a peptide consisting of amino acid of 33 to 40 of beta amyloid protein.
HY-P1903

β-Amyloid (35-42)
Amyloid-β Neurological Disease

β-Amyloid (35-42) is a peptide consisting of amino acid of 35 to 42 of beta amyloid protein.
HY-115872

β-Lactamase-IN-6
Bacterial Infection

β-Lactamase-IN-6 is a β-Lactamase inhibitor that shows high antibacetrial activity.
HY-P1898

β-Amyloid (13-27)
Amyloid-β Neurological Disease

β-Amyloid (13-27) is a peptide consisting of amino acid of 13 to 27 of beta amyloid protein.
HY-N1484

7beta-Hydroxylathyrol
Others Others

7beta-Hydroxylathyrol is a natural product.

HY-144659

Metallo-β-lactamase-IN-5	Apoptosis Bacterial	Infection
Metallo-β-lactamase-IN-5 (compound 5c) is a potent metallo-β-lactamases (MBL) inhibitor. Metallo-β-lactamase-IN-5 shows inhibitory activity against MBLs NDM-1 and VIM-1. Metallo-β-lactamase-IN-5 inhibits HUVECs with an IC₅₀ of 45 μg/mL. Metallo-β-lactamase-IN-5 plus Imipenem exhibits synergistic antimicrobial activity.

HY-107201

β-Cyclodextrin	Influenza Virus	Infection
β-Cyclodextrin is a cyclic polysaccharide composed of seven units of glucose (α-D-glucopyranose) linked by α-(1,4) type bonds. β-Cyclodextrin has often been used to enhance the solubility of drugs. β-Cyclodextrin has anti-influenza virus *H1N1* activities.

HY-N8486

β-Escin	FGFR	Cardiovascular Disease
β-Escin is the major active compound of Aesculus hippocastanum L. seeds. β-Escin exerts inhibitory effect on the basic fibroblast growth factor (bFGF)-induced proliferation, migration and tube formation, as well as CAM angiogenesis in vivo. β-Escin has the potential for the research of studying the molecular mechanism underlying the anti-angiogenic effect.

HY-B1739

Pregnenolone monosulfate 3β-Hydroxy-5-pregnen-20-one monosulfate	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate can protect the brain from cannabis intoxication. Pregnenolone monosulfate is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels.

HY-110189

Pregnenolone monosulfate sodium 3β-Hydroxy-5-pregnen-20-one monosulfate sodium	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication. Pregnenolone monosulfate sodium is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels.

HY-N10493

7β,25-Dihydroxycholesterol	Endogenous Metabolite	Inflammation/Immunology
7β,25-Dihydroxycholesterol is an endogenous metabolite and is found to act as chemoattractants for immune cells expressing EBI2.

HY-66007

Ac-β-Ala-OH
Endogenous Metabolite Metabolic Disease

Ac-β-Ala-OH (N-Acetyl-β-alanine), an abnormal amino acid metabolite, is a mono-N-protected amino acid (MPAA) ligand.
HY-P1510

β-Amyloid (1-11)
Amyloid-β Neurological Disease

β-Amyloid (1-11) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.
HY-P1517

β-Amyloid (31-35)
Amyloid-β Neurological Disease

β-Amyloid (31-35) is the shortest sequence of native Amyloid-β peptide that retains neurotoxic activity.

HY-N1415

β-Caryophyllene (-)-(E)-Caryophyllene; (−)-β-caryophyllene; (−)-trans-Caryophyllene	Cannabinoid Receptor Endogenous Metabolite	Cancer Infection Neurological Disease
β-Caryophyllene is a CB2 receptor agonist.

HY-146067

β-Nor-lapachone	Fungal Reactive Oxygen Species	Infection
β-Nor-lapachone is a *Candida glabrata* antibiofilm agent. β-Nor-lapachone can stimulate ROS production, inhibits efflux activity, adhesion, biofilm formation and the metabolism of mature biofilms of Candida glabrata. β-Nor-lapachone has antifungal activity.

HY-126144A

(E/Z)-GSK-3β inhibitor 1	GSK-3	Metabolic Disease
(E/Z)-GSK-3β inhibitor 1 is a racemic compound of (E)-GSK-3β inhibitor 1 and (Z)-GSK-3β inhibitor 1 isomers. GSK-3β inhibitor 1 (compound 3a) is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy, with an IC₅₀ of 4.9 nM.

HY-19773

*β-Lactamase-IN-1*	Bacterial	Infection
β-Lactamase-IN-1 is an inhibitor of *β-Lactamase* extracted from patent WO2016027249A1, page 77. β-Lactamase-IN-1 can be used to prepare of tricyclic nitrogen containing compound. β-Lactamase-IN-1 can be used for the research of neisseria gonorrhea infection.

HY-N5119

*Kaempferol-3-O-(2''-O-β-D-glucopyl)-β-D-rutinoside*	Others	Others
Kaempferol-3-O-(2''-O-β-D-glucopyl)-β-D-rutinoside is a natural glycoside that could be found in Camellia oleifera seeds.

HY-113418

Beta-Cortol
Endogenous Metabolite Endocrinology

Beta-Cortol is an androgen metabolite present in adults.

HY-N6616

Pinocembrin-7-O-β-D-glucopyranoside Pinocembrin-7-O-β-D-glucoside	Others	Others
Pinocembrin-7-O-β-D-glucopyranoside (Pinocembrin 7-O-β-D-Glucoside) is is a flavanone that enhances lipid peroxidation.

HY-P1850

β-Amyloid (1-20)
Amyloid-β Neurological Disease

β-Amyloid (1-20) consists of amino acids 1 to 20 of beta amyloid protein.
HY-126548

β-Secretase Inhibitor I
Beta-secretase Neurological Disease

β-Secretase Inhibitor I is an extremely potent β-secretase inhibitor with reduced cardiovascular and liver toxicity.

HY-139751

β-Lactamase-IN-4	Bacterial	Infection
β-Lactamase-IN-4 is a *β-lactamase* inhibitor extracted from patent WO2013149121A1, compound 708. β-Lactamase-IN-4 can be used for the research of bacterial infections.

HY-146075

β-Lactamase-IN-8	Bacterial	Infection
β-Lactamase-IN-8 (compound 20) is a potent and oral bioavailable broad-spectrum cyclic boronate *β-lactamase* inhibitor. β-Lactamase-IN-8 can be used for researching antibacteria.

HY-139779

*β-Lactamase-IN-5*	Bacterial	Infection
β-Lactamase-IN-5 is a *β-lactamase* inhibitor extracted from patent WO2013149121A1, compound 720. β-Lactamase-IN-5 can be used for the research of bacterial infections.

HY-150537

AChE/GSK-3β-IN-1	Cholinesterase (ChE) GSK-3 Microtubule/Tubulin ROS Kinase	Neurological Disease
AChE/GSK-3β-IN-1 (compound GT15) is a potent, dual *AChE/GSK-3β* inhibitor with IC₅₀ values of 1.2, 149.8 and 22.4 nM for hAChE , hBChE and hGSK-3β, respectively. AChE/GSK-3β-IN-1 penetrates the blood-brain barrier (BBB). AChE/GSK-3β-IN-1 has high kinase selectivity profiles for the CMGC kinase family. AChE/GSK-3β-IN-1 occupies the ATP binding site of DYRK1A. AChE/GSK-3β-IN-1 inhibits ROS expression and reduces oxidative stress. AChE/GSK-3β-IN-1 can be used for Alzheimer’s disease research.

HY-131108

β-Aspartylaspartic acid
L-β-Aspartyl-L-aspartic acid
Others Others

β-Aspartylaspartic acid is a natural compound found in Asparagus (Asparagus officinalis) Shoots.

HY-N2924

β-Amyrin palmitate	HMG-CoA Reductase (HMGCR)	Cardiovascular Disease Endocrinology
β-Amyrin palmitate shows HMG-CoA reductase inhibition. And β-Amyrin palmitate has anti-diabetes mellitus activity.

HY-N10645

*Rhamnocitrin 3-O-β-D-apiofuranosyl(1→2)-β-D-glucopyranoside*	Others	Others
Rhamnocitrin 3-O-β-D-apiofuranosyl(1→2)-β-D-glucopyranoside is a flavonol O-glycoside, isolated from Astragali semen of leguminous plants.

HY-N0171B

Beta-Sitosterol (purity>75%) β-Sitosterol (purity>75%); 22,23-Dihydrostigmasterol (purity>75%)	Apoptosis	Cancer Inflammation/Immunology Cardiovascular Disease
Beta-Sitosterol (purity>75%) includes 75% β-sitosterol and 10% campesterol. Beta-Sitosterol is a plant sterol. Beta-Sitosterol (purity>75%) interfere with multiple cell signaling pathways, including cell cycle, apoptosis, proliferation, survival, invasion, angiogenesis, metastasis and inflammation.

HY-151166

β-Glucuronidase-IN-2	Bacterial	Cancer
β-Glucuronidase-IN-2 is a potent E. coli *β-glucuronidase* inhibitor with an IC₅₀ value of 0.24 µM, an K_i value of 1.09 µM. β-Glucuronidase-IN-2 shows antiproliferative activity. β-Glucuronidase-IN-2 has the potential for the research of anti-cancer and anti-inflammatory therapies.

HY-113341

7β-Hydroxycholesterol	Others	Inflammation/Immunology Neurological Disease Cardiovascular Disease
7β-Hydroxycholesterol is an oxysterol that derived by the oxidation of cholesterol. 7β-hydroxycholesterol is a powerful inducer of oxidative stress, inducing dysfunction of organelles (mitochondria, lysosomes and peroxisomes) that can cause cell death.

HY-N10013

β-Damascone	Others	Others
β-Damascone is an aroma active rice volatile and is widely used in perfume compositions. β-Damascone has also received certain attention as a potential cancer chemopreventive and a mosquito and muscoid insecticide.

HY-122482

β-Rubromycin	HIV Reverse Transcriptase Antibiotic	Inflammation/Immunology
β-Rubromycin is a potent and selective inhibitor of human immunodeficiency virus-1 (HIV-1) RNA-directed DNA polymeras (reverse transcriptase). β-Rubromycin is a class of quinone antibacterials.

HY-N9802

n-Butyl-β-D-fructofuranoside	Apoptosis Bcl-2 Family	Cancer
n-Butyl-β-D-fructofuranoside could be isolated from kangaisan. n-Butyl-β-D-fructofuranoside induces apoptosis through the mitochondrial pathway. n-Butyl-β-D-fructofuranoside can be used for cancer research.

HY-147651

β-catenin-IN-4	β-catenin	Cancer
β-catenin-IN-4 (Compound 39) is a *β-catenin* inhibitor with a K_i of 0.64 μM. β-catenin-IN-4 reduces the protein expression levels of cyclin D1 and c-Myc.

HY-P1053

β-Amyloid (10-20)
Amyloid-β Neurological Disease

β-Amyloid (10-20) is a fragment of Amyloid-β peptide and maybe used in the research of neurological disease.

HY-138943

*5-Fluorouridine 5'-O-β-D-galactopyranoside* 5'-O-β-D-galactosyl-5-fluorouridine	Others	Cancer
5-Fluorouridine 5'-O-β-D-galactopyranoside (5'-O-β-D-galactosyl-5-fluorouridine) is a 5-Fluorouridine prodrug. 5-Fluorouridine 5'-O-β-D-galactopyranoside can be converted by the enzyme β-D-galactosidase to the potent antineoplastic agent 5-Fluorouridine.

HY-W024698

β-Cyclogeraniol
Others Others

β-Cyclogeraniol is a natural odour compound.

HY-150693

Estrogen receptor β antagonist 2	Estrogen Receptor/ERR	Cancer
Estrogen receptor β antagonist 2 is a potent and selective estrogen receptor β (ERβ) antagonist with IC₅₀s of 109.10, 0.63 µM for Erα and Erβ, respectively.

HY-P3777

β-Bag cell peptide	Potassium Channel	Neurological Disease
β-Bag cell peptide is a neuroactive peptide. β-Bag cell peptide elevates cyclic AMP levels in the bag cell neurons. β-Bag cell peptide decreases the amplitudes of the voltage-dependent potassium currents.

HY-N2513

β-Boswellic acid	Lipoxygenase DNA/RNA Synthesis	Cancer
β-Boswellic acid is isolated from the gum resin of Boswellia serrata. β-Boswellic acid is a nonreducing-type inhibitor of the 5-lipoxygenase (5-LO) product formation either interacting directly with the 5-LO or blocking its translocation. β-Boswellic acid inhibits the synthesis of DNA, RNA and protein in human leukemia HL-60 cells.

HY-P3550

β-Lipotropin (60-65)
β-LPH (60-65); [Arg0] Met-Enkephalin
Opioid Receptor Neurological Disease

β-Lipotropin (60-65) (β-LPH (60-65)), an opioid peptide, is a potent opioid agonist.

HY-115543

β-catenin-IN-37	β-catenin	Cancer
β-catenin-IN-37 is a selective β-Catenin/T-cell factor protein-protein interaction (β-catenin/Tcf PPI) inhibitor. β-catenin-IN-37 inhibits canonical Wnt signaling and the growth of colorectal cancer cells SW480 and HCT116 with the IC₅₀ values of 20 μM and 31 μM, respectively.

HY-144261

Metallo-β-lactamase-IN-3	Bacterial	Infection
Metallo-β-lactamase-IN-3 (compound 35) is a potent metallo-β-lactamases (MBL) inhibitor. Metallo-β-lactamase-IN-3 shows high activity against *VIM-1* and *NDM-1, with IC₅₀* of 0.6 and 1.0 μM, respectively. Metallo-β-lactamase-IN-3 does not show inhibition of IMP-7.

HY-N0171

Beta-Sitosterol (purity>80%) β-Sitosterol (purity>80%); 22,23-Dihydrostigmasterol (purity>80%)	Endogenous Metabolite Apoptosis	Cancer Inflammation/Immunology Cardiovascular Disease
Beta-Sitosterol (purity>80%) includes β-sitosterol (≥80%), stigmasterol, campesterol and brassicasterol mainly. Beta-Sitosterol is a plant sterol. Beta-Sitosterol (purity>80%) interfere with multiple cell signaling pathways, including cell cycle, apoptosis, proliferation, survival, invasion, angiogenesis, metastasis and inflammation.

HY-N8812

19-[(β-D-Glucopyranosyl)oxy]-19-oxo-ent-labda-8(17),13-dien-16,15-olide	NO Synthase	Inflammation/Immunology
19-[(β-D-Glucopyranosyl)oxy]-19-oxo-ent-labda-8(17),13-dien-16,15-olide, the metabolite of Neoandrographolide, inhibits nitric oxide (NO) production in lipopolysaccharide-activated macrophages.

HY-N0181A

Lumisterol 9β,10α-Ergosterol	Endogenous Metabolite	Metabolic Disease
Lumisterol (9β,10α-Ergosterol), a steroid compound, is the (9β,10α)-stereoisomer of Ergosterol (HY-N0181). Lumisterol is a photoprotective agent against UVB-induced DNA damage and anti-proliferative activities.

HY-N1940

β-Anhydroicaritin	Interleukin Related TNF Receptor MMP	Inflammation/Immunology
β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties. β-Anhydroicaritin ameliorates the degradation of periodontal tissue and inhibits the synthesis and secretion of TNF-α and MMP-3 in diabetic rats. β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca²⁺, and markedly decreases iNOS protein expression.

HY-D1510

*4-Nitrophenyl 2-O-(β-L-Fucopyranosyl)-β-D-Galactopyranoside*	Others	Others
4-Nitrophenyl 2-O-(β-L-Fucopyranosyl)-β-D-Galactopyranoside is a synthetic chromogenic substrate and can be used in the assay of α-fucosidases which hydrolyze the glycosidic linkage Fuc α1-2Gal. The assay is based on the sequential action of α-fucosidase and an exogenously added exo-β-d-galactosidase to release the easily measurable p-nitrophenol moiety.

HY-N4034

Hopane-3β,22-diol
Others Others

Hopane-3β,22-diol (compound 74) is a hopane isolated from A. mariesii.

HY-124265S2

4β-Hydroxycholesterol-d4	Endogenous Metabolite	Metabolic Disease
4β-Hydroxycholesterol-d4 is the deuterium labeled 4β-Hydroxycholesterol. 4β-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation.

HY-U00325

11β-HSD1-IN-1
11β-HSD Neurological Disease

11β-HSD1-IN-1 is an inhibitor of 11β-hydroxydehydrogenase 1 (11β-HSD1), with an IC₅₀ of 52 nM, and used for the treatment of pain.

HY-N1501

Beta-asarone	Others	Inflammation/Immunology Neurological Disease
Beta-asarone is a major ingredient of Acorus tatarinowii Schott, penetrates blood brain barrier, with the properties of immunosuppression, central nervous system inhibition, sedation, and hypothermy. Beta-asarone protects against Parkinson’s disease.

HY-N6740

Beta-Zearalanol	Apoptosis	Metabolic Disease
Beta-Zearalenol is an mycotoxin produced by Fusarium spp, which causes apoptosis and oxidative stress in mammalian reproductive cells. Beta-Zearalenol is the derivative of zearalenone (ZEA) which can conjugate with glucuronic acid.

HY-N5152

*(2′S)-4′-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranosylvisamminol*	Others	Cancer
(2′S)-4′-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranosylvisamminol is a chromone Glycoside that could be isolated from Roots of Saposhnikovia divaricate. (2′S)-4′-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranosylvisamminol exhibits weak anti-cancer activity in human cancer cell lines.

HY-N2168

Pinoresinol 4-O-β-D-glucopyranoside (+)-Pinoresinol 4-O-β-D-glucopyranoside	Others	Cardiovascular Disease
Pinoresinol 4-O-β-D-glucopyranoside ((+)-Pinoresinol 4-O-β-D-glucopyranoside) is the major active furofuran type lignans in Fructus Forsythiae. Pinoresinol 4-O-β-D-glucopyranoside shows antioxidant, blood pressure reducing, and cyclic adenosine monophosphate (cAMP) phosphodiesterase inhibitory effects.

HY-107753

XRP44X	Ras	Cancer Inflammation/Immunology
XRP44X inhibits Ras-induced transcription activation with the IC₅₀ of 10 nM. XRP44X inhibits activation of the Ras-Erk-1/2 pathway by FGF-2. XRP44X is an inhibitor of Ras/Erk activation of Elk3 that also affects microtubules.

HY-B0151S2

Pregnenolone-d4-1 3β-Hydroxy-5-pregnen-20-one-d4-1	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone-d4-1 (3β-Hydroxy-5-pregnen-20-one-d4-1) is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels.

HY-136464

β-catenin-IN-2	β-catenin	Cancer
β-catenin-IN-2 is a potent *β-catenin* inhibitor, compound H1B1, extracted from patent US20150374662A1. β-catenin-IN-2 can be used for the study of colorectal cancer.

HY-116055

(2R)-Glycerol-O-β-D-galactopyranoside 3-O-β-D-Galactopyranosyl-sn-glycerol	Others	Others
(2R)-Glycerol-O-β-D-galactopyranoside (3-O-β-D-Galactopyranosyl-sn-glycerol) is a good substrate for all three components of the lac operon, i.e. β-galactosidase, the lactose transporter and thiogalactoside transacetylase.

HY-P1362A

β-Amyloid (42-1), human TFA Amyloid β Peptide (42-1)(human) TFA	Amyloid-β	Neurological Disease
β-Amyloid (42-1), human TFA is the inactive form of Amyloid β Peptide (1-42). β-Amyloid (42-1), human TFA is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.

HY-130214

7-Hydroxypestalotin
LL-P880β
Endogenous Metabolite Others

7-Hydroxypestalotin (LL-P880β) is a fungal metabolite.

HY-B1449

Uridine β-Uridine	Endogenous Metabolite Nucleoside Antimetabolite/Analog	Cancer
Uridine (β-Uridine) is a glycosylated pyrimidine-analog containing uracil attached to a ribose ring (or more specifically, aribofuranose) via a β-N1-glycosidic bond.

HY-Y1750A

β-Aminopropionitrile hydrochloride BAPN hydrochloride	Monoamine Oxidase Endogenous Metabolite	Cancer Metabolic Disease
β-Aminopropionitrile (BAPN) hydrochloride is a specific, irreversible and orally active lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile hydrochloride targets the active site of LOX or LOXL isoenzymes.

HY-Y1750

β-Aminopropionitrile BAPN	Monoamine Oxidase Endogenous Metabolite	Cancer Metabolic Disease
β-Aminopropionitrile (BAPN) is a specific, irreversible and orally active lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile targets the active site of LOX or LOXL isoenzymes.

HY-W011063

Gly-Phe-β-naphthylamide	Cathepsin Others	Metabolic Disease
Gly-Phe-β-naphthylamide is the substrate of Cathepsin C. Gly-Phe-β-naphthylamide can be used to study intralysosomal hydrolysis, lysosomal membrane permeability, and the function of cathepsin C.

HY-147057A

FAP-2286 acetate	Others	Cancer
FAP-2286 acetate is the conjugate of a *fibroblast activation* protein** (FAP)-binding peptide. FAP-2286 acetate can be labeled with radionuclides for theranostic applications. FAP-2286 acetate has antitumor activity.

HY-15310

Ivermectin MK-933	Parasite HIV Mitophagy HSV SARS-CoV Antibiotic Autophagy Bacterial	Infection Cancer
Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. It is a positive allosteric effector of P2X₄ and the α7 neuronal nicotinic acetylcholine receptor (nAChRs). Ivermectin also inhibits bovine herpesvirus1 (BoHV-1) replication and inhibits *BoHV-1* DNA polymerase nuclear import. Ivermectin is a candidate therapeutic against *SARS-CoV-2/COVID-19*.

HY-123489S

3α,21-Dihydroxy-5α-pregnan-20-one-d3 THDOC-d3	GABA Receptor	Neurological Disease
3α,21-Dihydroxy-5α-pregnan-20-one-d3 (THDOC-d3) is the deuterium labeled 3α,21-Dihydroxy-5α-pregnan-20-one. 3α,21-Dihydroxy-5α-pregnan-20-one (THDOC), an endogenous neurosteroid, is a positive modulator of GABA_A receptors. 3α,21-Dihydroxy-5α-pregnan-20-one potentiates neuronal response to low concentrations of GABA at α4β1δ GABA_A receptors in vitro.

HY-P3793

Amyloid β-Protein (33-42) (TFA)	Amyloid-β	Neurological Disease
Amyloid β-Protein (33-42) TFA is the residues 33-42 fragment of the β-amyloid protein. Amyloid β-Protein (33-42) TFA inhibits Aβ42-induced toxicity.

HY-130269

β-Naphthoflavone-CH2-OH β-NF-CH2-OH	Ligands for E3 Ligase	Cancer
β-Naphthoflavone-CH2-OH (β-NF-CH2-OH) is a ligand for arylhydrocarbon receptor (AhR) E3 ligase. β-Naphthoflavone-CH2-OH can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs (e.g., β-naphthoflavone-JQ1) that recruit the AhR E3 ligase complex by incorporating AhR ligands into chimeric molecules. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins ^[1].

HY-124265S1

4β-Hydroxycholesterol-d5	Endogenous Metabolite	Metabolic Disease
4β-Hydroxycholesterol-d5 is the deuterium labeled 4β-Hydroxycholesterol (HY-124265). 4β-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation.

HY-16673

PSN632408	GPR119	Metabolic Disease
PSN632408, a selective, orally active GPR119 agonist, shows similar potency to OEA at both recombinant mouse and human GPR119 receptors (EC₅₀=5.6 and 7.9 uM, respectively). PSN632408 can stimulate β-cell replication and improve islet graft function. PSN632408 has the potential for the research of obesity and related metabolic disorders.

HY-W324243

11β-HSD1-IN-9	Others	Metabolic Disease
11β-HSD1-IN-9 (compound c4a) is a potent *11β-HSD1* inhibitor with IC₅₀ values of 0.48 and 1.3 µM for human and murine *11β-HSD1, respectively. 11β-HSD1-IN-9* competitively interacts with rat *11β-HSD1. 11β-HSD1-IN-19* can be used in studies of obesity, hyperglycemia and cognitive impairment.

HY-P1286

PKC β pseudosubstrate
PKC Neurological Disease

PKC β pseudosubstrate is a selective cell-permeable inhibitor of PKC.

HY-145381

11β-HSD1-IN-6	11β-HSD	Metabolic Disease
11β-HSD1-IN-6 is a an *11β-HSD-1* inhibitor. The 11β hydroxysteroid dehydrogenase enzymes (11β-HSDs) mediate the interconversion of the glucocorticoid (GC) corticosterone or cortisol to an inactive form, 11-dehydrocorticosterone (11-DHC) or Cortisone, respectively.

HY-N2923

β-Amyrin acetate	HMG-CoA Reductase (HMGCR) Fungal	Infection Metabolic Disease Inflammation/Immunology Cardiovascular Disease
β-Amyrin acetate is a triterpenoid with potent anti-inflammatory, antifungal, anti-diabetic, anti-hyperlipidemic activities. β-Amyrin acetate can inhibit HMG-CoA reductase activity by locating in the hydrophobic binding cleft of HMG CoA reductase.

HY-P3517

β-Endorphin (6-31), human β-EP (6-31), human	Opioid Receptor	Endocrinology Neurological Disease
β-Endorphin, an endogenous opioid neuropeptide, is an opioid receptor agonist. β-Endorphin binds preferentially to μ-opioid receptors and is produced in certain neurons of the central and peripheral nervous system and is one of three endorphins produced in humans. β-Endorphin can be used to reduce stress and maintain homeostasis in the body and is involved in neurological pain perception regulation.

HY-P2551

Biotin-β-Amyloid (17-40)	Amyloid-β	Neurological Disease
Biotin-β-Amyloid (17-40) is a N-terminal-labelled biotinylated amyloid-ß-(1-40) peptide. β-Amyloid (17-40) is a 24-residue fragment of the Aβ protein via post-translational processing of amyloid precursor protein (APP).

HY-N6851

Glycyrrhetic acid 3-O-β-D-glucuronide	Others	Inflammation/Immunology
Glycyrrhetic acid 3-O-β-D-glucuronide, isolated from glycyrrhiza, is an important derivative of glycyrrhizin (GL) with an anti -allergic activity. Glycyrrhetic acid 3-O-β-D-glucuronide (GAMG) shows that β‐glucuronidases (β‐GUS) are key GAMG-producing enzymes, displaying a high potential to convert GL directly into GAMG.Glycyrrhetic acid 3-O-β-D-glucuronide is valuable as a sweetener.

HY-145433

17β-HSD1-IN-1	Others	Cancer
17β-HSD1-IN-1 (Compound 1) is a highly selective *17β-HSD1* inhibitor with IC₅₀s of 5.6 and 3155 nM for 17β-HSD1 and 17β-HSD2, respectively. 17β-HSD1-IN-1 can be used for the research of non-small cell lung cancer (NSCLC).

HY-P1378

β-Amyloid (1-43)(human)	Amyloid-β	Neurological Disease
β-Amyloid (1-43)(human) is more prone to aggregation and has higher toxic properties than the long-known Aβ1-42. β-Amyloid (1-43)(human) shows a correlation with both sAPPα and sAPPβ. β-Amyloid (1-43)(human) could be considered an added Alzheimer's disease (AD) biomarker together with the others already in use.

HY-117958

HJC0197	Ras	Cancer Metabolic Disease Cardiovascular Disease
HJC0197 is a potent *Epac1* (exchange protein directly activated by cAMP 1) and Epac2 (IC₅₀=5.9 μM for Epac2) antagonist. HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM in the presence of equal concentration of cAMP.

HY-138795

Curcumin-β-D-glucuronide	Others	Cancer
Curcumin-β-D-glucuronide is a major metabolite after oral intake of Curcumin in hepatic tissue and portal blood. Curcumin-β-D-glucuronide can be used for the research of colon cancer.

HY-N7401

Entadamide-A-β-D-glucopyranoside	Complement System	Others
Entadamide-A-β-D-glucopyranoside is one of the major components in the seeds of Entada phaseoloides. Entadamide-A-β-D-glucopyranoside has anti-complement activitie.

HY-147055

THR-β agonist 5
Others Metabolic Disease

THR-β agonist 5 (compound 54) is a potent THR-β agonist, with an EC₅₀ of <50 nM.

HY-126304A

Glycerophosphoric acid disodium salt hydrate (α and β mixture)	Others	Others
Glycerophosphoric acid (disodium salt hydrate) (α and β mixture) is a complex contains α and β Glycerophosphoric acid isomers.

HY-N5137

*L-Borneol 7-O-[β-D-apiofuranosyl-(1→6)]-β-D-glucopyranoside* OJV-II	Others	Others
L-Borneol 7-O-[β-D-apiofuranosyl-(1→6)]-β-D-glucopyranoside is one of the components of the Shengmai injection.

HY-P3515

β-Lipotropin (61-69)
β-LPH (61-69)
Opioid Receptor Neurological Disease

β-Lipotropin (61-69) is a potent opioid agonist.

HY-P1854

β-Amyloid (1-9)	Amyloid-β	Neurological Disease
β-Amyloid (1-9), an N-terminal fragment of beta amyloid, consists of amino acid residues 1 to 9. β-Amyloid (1-9) contains a B cell epitope, but it does not include T cell epitopes. Omission of residues 1 to 9 from the full-length Alzheimer'sβ-Amyloid peptide 1 to 40 does not prevent the peptide from forming amyloid fibrils or eliminate fibril polymorphism ^[1].

HY-135594

4'-Raloxifene-β-D-glucopyranoside	Estrogen Receptor/ERR	Metabolic Disease
4'-Raloxifene-β-D-glucopyranoside, a metabolite of Raloxifene, is a benzothiophene glucuronidated at the 4' postion. 4'-Raloxifene-β-D-glucopyranoside is a selective and orally active estrogen receptor antagonist. 4'-Raloxifene-β-D-glucopyranoside can be used for inhibiting bone loss and resorption, and lowering lipid levels. 4'-Raloxifene-β-D-glucopyranoside, example 5, is extracted from patent US5567820A.

HY-135595

6-Raloxifene-β-D-glucopyranoside	Estrogen Receptor/ERR Drug Metabolite	Metabolic Disease
6-Raloxifene-β-D-glucopyranoside, a derivative of Raloxifene, is a benzothiophene glucuronidated at the 6' postion. 6-Raloxifene-β-D-glucopyranoside is a selective and orally active estrogen receptor antagonist. 6-Raloxifene-β-D-glucopyranoside can be used for inhibiting bone loss and resorption, and lowering lipid levels. 6'-Raloxifene-β-D-glucopyranoside, compound Ia, is extracted from patent US5567820A.

HY-B0172B

Isolithocholic acid 3β-Hydroxy-5β-cholanic acid; 3-Epilithocholic acid; β-Lithocholic acid	Endogenous Metabolite	Endocrinology
Isolithocholic acid (β-Lithocholic acid) is an isomer of Lithocholic acid. Isolithocholic acid, a bile acid, is formed by microbial metabolism of Lithocholic acid or Lithocholic acid 3α-sulfate.

HY-N0180S

18β-Glycyrrhetinic acid-d3	Endogenous Metabolite	Cancer Inflammation/Immunology
18β-Glycyrrhetinic acid-d3 is deuterium labeled 18β-Glycyrrhetinic acid. 18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhizae Radix and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.

HY-107373

β-Chloro-L-alanine L-β-Chloroalanine	Bacterial	Infection
β-Chloro-L-alanine is a bacteriostatic amino acid analog which inhibits a number of enzymes, including threonine deaminase and alanine racemase.

HY-148055

Wnt/β-catenin agonist 3	β-catenin	Cardiovascular Disease
Wnt/β-catenin agonist 3 (compound 98) is a *Wnt/β-catenin* signalling pathway agonist. Wnt/β-catenin agonist 3 can be used for the research of osteoporosis.

HY-N8934

6β-Hydroxytomentosin	Others	Cancer
6β-Hydroxytomentosin, a sesquiterpenoid, can be found in flowers of Inula japonica. 6β-Hydroxytomentosin exhibits weak cytotoxicities against A549, SK-OV-3, HepG-2 and HT-29 cell lines.

HY-145969

β-S-ARCA	Others	Others
β-S-ARCA is a mRNA 7-methylguanosine (m⁷G) cap analog carrying a phosphorothioate (PS) moiety. mRNAs incorporating β-S-ARCA have elongated cellular half-lives and showed augmented protein expression. β-S-ARCA D1 has been applied in researching experimental mRNA-based anticancer vaccines.

HY-107670

Dihydro-β-erythroidine hydrobromide DHβE hydrobromide	nAChR	Neurological Disease
Dihydro-β-erythroidine (DHβE) hydrobromide is a potent, orally active, and competitive antagonist of neuronal nAChRs. Dihydro-β-erythroidine hydrobromide shows selectivity for α4β4 and α4β2 nAChRs, with IC₅₀s of 0.19 and 0.37 μM, respectively. Antidepressant-like activities.

HY-W129359

11β-HSD1-IN-8	Others	Metabolic Disease Neurological Disease
11β-HSD1-IN-8 (compound c6a) is a *11β‑HSD1* inhibitor with an IC₅₀ value of 2.3 μM for human 11β‑HSD1. 11β-HSD1-IN-8 can be used for the research of diabetes and cognitive decline.

HY-W106057

11β-HSD1-IN-7	Others	Metabolic Disease Neurological Disease
11β-HSD1-IN-7 (compound c10a) is a *11β‑HSD1* inhibitor with an IC₅₀ value of 1.9 μM for human 11β‑HSD1. 11β-HSD1-IN-7 can be used for the research of diabetes and cognitive decline.

HY-124957

β-NETA	Cholinesterase (ChE) Apoptosis	Cancer
β-NETA is a potent and noncompetitive choline acetyltransferase (ChA; IC₅₀=76 μM) and cholinesterase (ChE; IC₅₀=40 µM) inhibitor. β-NETA weakly inhibits acetylcholinesterase (AChE; *IC₅₀=1 mM).*

HY-114134

Epoetin beta rhEPO; EPOCH; Genetical recombination	Others	Cancer Metabolic Disease
Epoetin beta (rhEPO) is a recombinant form of erythropoietin. Epoetin beta is responsible for the maintenance of erythropoiesis and can be used for anaemia research.

HY-W015084S

β-Ionone-13C3	Apoptosis	Cancer
β-Ionone-13C3 is the 13C-labeled β-Ionone. β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. Anti-cancer activity.

HY-B0708S

β-Estradiol 17-acetate-d3 1,3,5(10)-Estratriene-3,17β-diol 17-acetate-d3	Estrogen Receptor/ERR	Endocrinology
β-Estradiol 17-acetate-d3 (1,3,5(10)-Estratriene-3,17β-diol 17-acetate-d3) is the deuterium labeled β-Estradiol 17-acetate. β-Estradiol 17-acetate is a metabolite of estradiol.

HY-144100

β-Lactamase-IN-7	Bacterial	Infection
β-Lactamase-IN-7 (compound 14) is a potent VIM-Type metallo-β-lactamase inhibitor, with K_is of 1.26 μM and 0.54 μM for *VIM-1* and VIM-4, respectively. β-Lactamase-IN-7 can effectively inhibit Klebsiella pneumoniae.

HY-126304

β-Glycerophosphate disodium salt hydrate	Phosphatase Endogenous Metabolite	Metabolic Disease
β-Glycerophosphate disodium salt hydrate, an endogenous metabolite, is a phosphatase inhibitor.

HY-B0141S2

Estradiol-d5 β-Estradiol-d5; 17β-Estradiol-d5; 17β-Oestradiol-d5	Estrogen Receptor/ERR Endogenous Metabolite	Endocrinology Cancer
Estradiol-d5 is deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.

HY-N2188

Beta-Acetoxyisovalerylshikonin
Others Inflammation/Immunology

Beta-Acetoxyisovalerylshikonin is a naphthoquinone derivative isolated from Arnebia euchroma.
HY-124670

1beta-Hydroxyalantolactone
Others Inflammation/Immunology

1beta-Hydroxyalantolactone modulate many processes that influence inflammatory reactions.

HY-N7489

β-Hederin	Parasite	Infection Inflammation/Immunology
β-Hederin, a saponin isolated from Hedera helix L.(Araliaceae), possesses antileishmanial activity. β-Hederin exhibits IC₅₀ values of 1.5 μM, 68 nM and 4.57 μM in L. Mexicana promastigotes, L. mexicana amastigotes and THP1 cells, respectively.

HY-151643

beta-Glc-TEG-Alkyne	Others	Others
beta-Glc-TEG-Alkyne is a click chemistry reagent containing an alkynes group. beta-Glc-TEG-Alkyne can be used for the research of various biochemical.

HY-135103S

Tauro-β-muricholic acid-d4 sodium	FXR	Cancer
Tauro-β-muricholic acid-d4 sodium is the deuterium labeled Tauro-β-muricholic acid sodium. Tauro-β-muricholic Acid sodium (T-βMCA sodium), a endogenous metabolite, is a competitive and reversible farnesoid X receptor (FXR) antagonist, with an IC₅₀ of 40 μM.

HY-123633

4-Methylumbelliferyl β-D-Glucopyranoside	Glucosidase Others	Others
4-Methylumbelliferyl β-D-Glucopyranoside, a β-D-glucoside, is a fluorogenic substrate for *β-glucosidase, utilizes to assay β-glucosidase activity.* 4-Methylumbelliferyl β-D-Glucopyranoside releases the highly fluorescent 4-methylumbelliferyl (4-MU), which has an emission maximum at 445-454 nm. The excitation maximum for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively.

HY-N1590

8β,18-Dihydroxysandaracopimar-15-ene
Others Others

8β,18-Dihydroxysandaracopimar-15-ene is a compound isolated from Thuja orientalis.
HY-P1524

β-Amyloid (1-14),mouse,rat
Amyloid-β Neurological Disease

β-Amyloid (1-14),mouse,rat is a 1 to 14 fragment of Amyloid-β peptide.

HY-103081

*β-Glucuronidase-IN-1*	Bacterial	Cancer Infection
β-Glucuronidase-IN-1 is a potent, selective, uncompetitive, and orally active E. coli bacterial β-glucuronidase inhibitor, exhibiting an IC₅₀ and a K_i of 283 nM and 164 nM, respectively.

HY-B0151S

Pregnenolone-d4 3β-Hydroxy-5-pregnen-20-one-d4	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone-d4 is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels.

HY-N5111

Aloe-emodin-3-(hydroxymethyl)-O-β-D-glucopyranoside Aloe-emodin 3-O-β-D-glucoside	Others	Others
Aloe-emodin-3-(hydroxymethyl)-O-β-D-glucopyranoside (Aloe-emodin 3-O-β-D-glucoside) is a natural antraquinone.

HY-N1633

1-Methoxycarbonyl-β-carboline
Others Others

1-Methoxycarbonyl-β-carboline is a natural alkaloid.
HY-148378

5β-Dihydrocortisone acetate
Others Others

5β-Dihydrocortisone acetate can be used for the synthesis of tetrahydrocortisone 3-glucuronide.

HY-P1502

β-Endorphin, human	Opioid Receptor	Neurological Disease
β-Endorphin, human, a prominent endogenous peptide, existing in the hypophysis cerebri and hypothalamus, is an agonist of opioid receptor, with preferred affinity for μ-opioid receptor and δ-opioid receptor; β-Endorphin, human exhibits antinociception activity.

HY-141379

N-Bromoacetyl-β-alanine	PROTAC Linkers ADC Linker	Cancer
N-Bromoacetyl-β-alanine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. N-Bromoacetyl-β-alanine is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-P1378A

β-Amyloid (1-43)(human) TFA	Amyloid-β	Neurological Disease
β-Amyloid (1-43)(human) TFA is more prone to aggregation and has higher toxic properties than the long-known Aβ1-42. β-Amyloid (1-43)(human) TFA shows a correlation with both sAPPα and sAPPβ. β-Amyloid (1-43)(human) TFA could be considered an added Alzheimer's disease (AD) biomarker together with the others already in use.

HY-P1387

β-Amyloid (1-40) (rat)	Amyloid-β Apoptosis	Neurological Disease
β-Amyloid (1-40) (rat) is a rat form of the amyloid β-peptide, which accumulates as an insoluble extracellular deposit around neurons, giving rise to the senile plaques associated with Alzheimer's disease (AD). β-Amyloid (1-40) (rat) increases ⁴⁵Ca²⁺ influx, induces neurodegeneration in the rat hippocampal neurons of the CA1 subfield. β-Amyloid (1-40) (rat) induces apoptosis. β-Amyloid (1-40) (rat) can be used for the research of Alzheimer's disease.

HY-150511

3-(3-Phenoxybenzyl)amino-β-carboline	Microtubule/Tubulin Apoptosis	Cancer
3-(3-Phenoxybenzyl)amino-β-carboline is a potent tubulin inhibitor. 3-(3-Phenoxybenzyl)amino-β-carboline promotes selective degradation of αβ-tubulin heterodimers. 3-(3-Phenoxybenzyl)amino-β-carboline induces G2/M phase cell cycle arrest and apoptosis. 3-(3-Phenoxybenzyl)amino-β-carboline exhibits anticancer activity.

HY-N10593

Ladanetin-6-O-β-D-glucopyranoside	Reactive Oxygen Species	Cardiovascular Disease
Ladanetin-6-O-β-D-glucopyranoside is an active flavonoid. Ladanetin-6-O-β-D-glucopyranoside has antioxidative effect. Ladanetin-6-O-β-D-glucopyranoside can be used for the research of cardioprotective effects.

HY-116284

Methyl β-D-glucopyranoside
Methyl β-D-glucoside
Others Others

Methyl β-D-glucopyranoside is used to synthesize natural glycophenolics via enzymatic caffeoylation.

HY-P9984

Etrolizumab rhuMAb beta7; RG7413; PRO145223	Integrin	Cancer
Etrolizumab (rhuMAb Beta7) is a gut-selective, anti-β7 integrin monoclonal antibody. Etrolizumab is specific targeting of the β7 subunit of α4β7 and αEβ7 integrins with K_i values of 18 nM and 1800 pM for Human α4β7 and Human αEβ7-293, respectively. Etrolizumab can be used in research of inflammatory bowel disease (IBD).

HY-N1017

11β-Hydroxycedrelone
Others Others

11β-Hydroxycedrelone is a natural tetranortriterpenoid compound isolated from the bark of Walsura yunnanensis.

HY-136537A

N-β-alanyldopamine hydrochloride NBAD hydrochloride	Endogenous Metabolite	Neurological Disease
N-β-alanyldopamine hydrochloride (NBAD hydrochloride) is the major dopamine derivative in haemolymph.

HY-W060074

1-Acetyl-β-carboline
Others Infection

1-Acetyl-β-carboline is metabolite of streptomyces kasugaensis.
HY-B0708

β-Estradiol 17-acetate
1,3,5(10)-Estratriene-3,17β-diol 17-acetate
Estrogen Receptor/ERR Endocrinology

β-Estradiol 17-acetate is a metabolite of estradiol.

HY-P1567

β-Amyloid (10-35), amide	Amyloid-β	Neurological Disease
β-Amyloid (10-35), amide is composed of 26 aa (10-35 residues of the Aβ peptide) and is the primary component of the amyloid plaques of Alzheimer’s disease.

HY-147311

NSC622608
PD-1/PD-L1 Inflammation/Immunology

NSC622608 is a V-domain Ig suppressor of T-cell activation (VISTA) ligand with an IC₅₀ value of 4.8 μM.
HY-10590

TWS119
GSK-3 Autophagy Neurological Disease Cancer

TWS119 is a specific inhibitor of GSK-3β, with an IC₅₀ of 30 nM, and activates the wnt/β-catenin pathway.

HY-W019721

Cyclosporin D	Nuclear Factor of activated T Cells (NFAT)	Inflammation/Immunology
Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A. Cyclosporin A is a potent immunosuppressant drug, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc).

HY-136542

H-β-Ala-AMC TFA
Others Cancer

H-β-Ala-AMC TFA is a substrate for aminopeptidase.
HY-128737

Methyl β-D-Galactopyranoside
Endogenous Metabolite Metabolic Disease

Methyl β-D-Galactopyranoside is an endogenous metabolite.

HY-107271

Imperialine 3-β-D-glucoside	Others	Cancer
Imperialine 3-β-D-glucoside is the glycoside of Imperialine. Imperialine 3-β-D-glucoside may exhibit anti-tumor properties against multi-drug resistant tumor cells.

HY-147037

AMPK activator 7	AMPK	Metabolic Disease Cardiovascular Disease
AMPK activator 7 (compound I-3-24) is a an AMPK activator with the EC₅₀ of 8.8 nM. AMPK activator 7 can be used for the research of diseases involving AMPK, particularly diseases such as type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia and/or hypertension.

HY-P9911A

Vedolizumab (anti-α4β7-integrin)	Integrin	Inflammation/Immunology
Vedolizumab (anti-α4β7-integrin) is a humanized IgG1 monoclonal antibody that targets the α4β7 integrin for the treatment of ulcerative colitis and Crohn's disease.

HY-130256

*β-NF-JQ1*	PROTACs Epigenetic Reader Domain	Cancer
β-NF-JQ1 is a PROTAC that recruits Aryl Hydrocarbon Receptor E3 ligase to target proteins. β-NF-JQ1 is directed against bromodomain-containing (BRD) proteins using β-NF as an AhR ligand, induces the interaction of AhR and BRD proteins, and displays effective anticancer activity that correlated with protein knockdown activity.

HY-143415

Metallo-β-lactamase-IN-7	Bacterial	Infection
Metallo-β-lactamase-IN-7 is a potent VIM-Type metallo-β-lactamase inhibitor with IC₅₀s of 0.019 μM, 13.64 μM, 0.38 μM for VIM-2, VIM-1 and VIM-5. Metallo-β-lactamase-IN-7 potentiate antibacterial activity of Meropenem against the Gram-negative bacterial strains.

HY-N4099

*Luteolin-3-O-beta-D-glucuronide*	Others	Inflammation/Immunology
Luteolin-3-O-beta-D-glucuronide is a luteolin glucosiduronic acid consisting of luteolin having a beta-D-glucosiduronic acid residue attached at the 3'-position.

HY-134425

β-Methylcrotonyl coenzyme A lithium	Endogenous Metabolite	Metabolic Disease
β-Methylcrotonyl coenzyme A lithium is an intermediate in leucine metabolism and can be used as a substrate to study the specificity and kinetics of β-methylcrotonyl coenzyme A carboxylase (MCCase).

HY-U00391

β3-AR agonist 2
Adrenergic Receptor Metabolic Disease Endocrinology

β₃-AR agonist 2 is a potent and selective β₃-adrenergic receptor (β₃-AR) agonist with an EC₅₀ of 8 nM.
HY-P1286A

PKC β pseudosubstrate TFA
PKC Neurological Disease

PKC β pseudosubstrate TFA is a selective cell-permeable inhibitor of PKC.

HY-151627

11β-HSD1-IN-11	11β-HSD	Metabolic Disease Neurological Disease
11β-HSD1-IN-11 (Compound c1a) is a competitive *11β-HSD1* inhibitor with IC₅₀s of 0.34 μM and 0.13 μM against rat and human 11β-HSD1, respectively.

HY-P1548

β-CGRP, human Human β-CGRP; CGRP-II (Human)	CGRP Receptor	Inflammation/Immunology Cardiovascular Disease
β-CGRP, human (Human β-CGRP) is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC₅₀s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells.

HY-101953

β-Apo-13-carotenone
D'Orenone
RAR/RXR Others

β-Apo-13-carotenone (D'Orenone) is a naturally occurring β-apocarotenoid functioned as an antagonist of RXRα.

HY-134426

DL-β-Hydroxybutyryl coenzyme A lithium	Endogenous Metabolite	Metabolic Disease
DL-β-Hydroxybutyryl coenzyme A lithium is an intermediate in the fermentation of butyric acid and the metabolism of lysine and tryptophan, and is produced from β-hydroxybutyric acid by short-chain-CoA synthase.

HY-N2212

Arctigenin 4'-O-β-gentiobioside
Others Inflammation/Immunology Metabolic Disease

Arctigenin 4'-O-β-gentiobioside is a natural compound.

HY-137522

Zidovudine O-β-D-glucuronide sodium 3'-Azido-3'-deoxythymidine β-D-glucuronide sodium	Drug Metabolite	Others
Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the major metabolite of Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection.

HY-W015084

β-Ionone
Apoptosis Cancer

β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. Anti-cancer activity.

HY-N0180

18β-Glycyrrhetinic acid	Endogenous Metabolite	Cancer Inflammation/Immunology
18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhiza uralensis and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.

HY-143614

THR-β agonist 3	Others	Metabolic Disease
THR-β agonist 3 is a potent agonist of *THR-β. THR-β agonist 3 has the potential for the research of metabolic diseases such as obesity, hyperlipidemia, hypercholesterolemia, diabetes and other conditions such as steatosis and non-alcoholic steatohepatitis (NASH), atherosclerosis and other related conditions and diseases (extracted from patent WO2021129827A1, compound 6).*

HY-143613

THR-β agonist 2	Others	Metabolic Disease
THR-β agonist 2 is a potent agonist of *THR-β. THR-β agonist 2 has the potential for the research of metabolic diseases such as obesity, hyperlipidemia, hypercholesterolemia, diabetes and other conditions such as steatosis and non-alcoholic steatohepatitis (NASH), atherosclerosis and other related conditions and diseases (extracted from patent WO2021121210A1, compound 3).*

HY-W324220

11β-HSD1-IN-10	Others	Metabolic Disease
11β-HSD1-IN-10 (compound c3a) is a potent *11β-HSD1* inhibitor (IC₅₀=1.8 µM for human). 11β-HSD1-IN-10 can be used in studies of obesity, hyperglycemia and cognitive impairment.

HY-142917

THR-β agonist 4	Others	Metabolic Disease
THR-β agonist 4 is a potent agonist of *THR-β. THR-β agonist 4 has the potential for the research of metabolic diseases such as obesity, hyperlipidemia, hypercholesterolemia, diabetes and other conditions such as steatosis and non-alcoholic steatohepatitis (NASH), atherosclerosis and other related conditions and diseases (extracted from patent WO2021143706A1, compound 72).*

HY-147204

Mc-Alanyl-Alanyl-Asparagine-PAB-MMAE	Others	Cancer
Mc-Alanyl-Alanyl-Asparagine-PAB-MMAE (compound S6) is a potent anticancer agent, which can be specific activated by tumor microenvironment. Mc-Alanyl-Alanyl-Asparagine-PAB-MMAE can suppress tumor growth in mice (extracted from patent CN104147612A).

HY-N0181AS

Lumisterol-d3 9β,10α-Ergosterol-d3	Endogenous Metabolite	Metabolic Disease
Lumisterol-d3 (9β,10α-Ergosterol-d3) is the deuterium labeled Lumisterol. Lumisterol (9β,10α-Ergosterol), a steroid compound, is the (9β,10α)-stereoisomer of Ergosterol. Lumisterol is a photoprotective agent against UVB-induced DNA damage and anti-proliferative activities.

HY-N0181AS1

Lumisterol-d5 9β,10α-Ergosterol-d5	Endogenous Metabolite	Metabolic Disease
Lumisterol-d5 (9β,10α-Ergosterol-d5) is the deuterium labeled Lumisterol. Lumisterol (9β,10α-Ergosterol), a steroid compound, is the (9β,10α)-stereoisomer of Ergosterol. Lumisterol is a photoprotective agent against UVB-induced DNA damage and anti-proliferative activities.

HY-146165

Metallo-β-lactamase-IN-8	Bacterial	Infection
Metallo-β-lactamase-IN-8 (compound 17) is a potent, reversible and competitive broad-spectrum inhibitor of metallo-β-lactamases (MβLs), with IC₅₀s of 1.3 μM, 5.7 μM, 9.8 μM, and 9.9 μM for L1, ImiS, *IMP-1* and VIM-2, respectively. Metallo-β-lactamase-IN-8 exhibits antibacterial activity.

HY-N2142

*3-O-beta-Allopyranosyl-(1->4)-beta-oleandropyranosyl-11-O-isobutyryl-12-O-acetyltenacigenin B*	Others	Cancer
3-O-beta-Allopyranosyl-(1->4)-beta-oleandropyranosyl-11-O-isobutyryl-12-O-acetyltenacigenin B is a chemical constituent of the plant Poria cocos ^[1].

HY-P1363

β-Amyloid (1-42), human TFA Amyloid β-Peptide (1-42) (human) TFA	Amyloid-β	Neurological Disease
β-Amyloid (1-42), human TFA (Amyloid β-Peptide (1-42) (human) TFA) is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.

HY-102011

BMS-1166	PD-1/PD-L1	Cancer Inflammation/Immunology
BMS-1166 is a potent *PD-1/PD-L1* immune checkpoint inhibitor. BMS-1166 induces dimerization of PD-L1 and blocks its interaction with PD-1, with an IC₅₀ of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation.

HY-N6904

Crocetin β-Crocetin	Amyloid-β	Inflammation/Immunology Neurological Disease
Crocetin (β-Crocetin), isolated from Crocus sativus, possesses anti-inflammatory, neuroprotective and antioxidant activity. Crocetin promotes clearance of *amyloid-β* by inducing autophagy via the STK11/LKB1-mediated AMPK pathway.

HY-D0886

β-Glycerophosphate disodium salt pentahydrate
Phosphatase Endogenous Metabolite Cancer Neurological Disease

β-Glycerophosphate disodium salt pentahydrate is a phosphatase inhibitor.
HY-113019S

3β,7α-Dihydroxycholest-5-enoic acid-d3
Endogenous Metabolite Others

3β,7α-Dihydroxycholest-5-enoic acid-d3 is deuterium labeled 3β,7α-Dihydroxycholest-5-enoic acid.

HY-N2100

*6'-O-beta-D-Glucosylgentiopicroside*	Reactive Oxygen Species Others	Metabolic Disease
6'-O-beta-D-Glucosylgentiopicroside is a secoiridoid isolated from the roots of G. straminea. 6'-O-beta-D-Glucosylgentiopicroside strongly suppresses N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide generation.

HY-148225

Fulvestrant 3-β-D-Glucuronide	Others	Cancer
Fulvestrant 3-β-D-Glucuronide, a metabolite, is glucuronide and sulfate conjugates of Fulvestrant (HY-13636), a pure anti-estrogenic steroid. Fulvestrant 3-β-D-Glucuronide can be used for the research of breast cancer.

HY-114321

Wnt/β-catenin agonist 1
Wnt Cancer

Wnt/β-catenin agonist 1 (compound 3f) is a Wnt/β-catenin signalling pathway agonist, with an EC₅₀ of 0.27 μM.

HY-113949A

Methyl 2,3-O-Isopropylidene-β-L-ribofuranoside	Others	Others
Methyl 2,3-O-Isopropylidene-β-L-ribofuranoside is an enantiomer of Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside. Methyl 2,3-O-Isopropylidene-β-L-ribofuranoside is a derivative of L-ribose.

HY-W039892

4-Nitrophenyl β-D-glucuronide pNPG_1	Others	Others
4-Nitrophenyl β-D-glucuronide (pNPG_1) is aderivative of 4-nitrophenol 4-Nitrophenyl β-D-glucuronide is a chromogenic compound and is the chromogenic substrate for β-glucuronidase.

HY-W250154

β-Nicotinamide adenine dinucleotide reduced dipotassium	Endogenous Metabolite	Metabolic Disease
β-Nicotinamide adenine dinucleotide reduced dipotassium is an orally active reduced coenzyme. β-Nicotinamide adenine dinucleotide reduced dipotassium is a donor of ADP-ribose units in ADP-ribosylaton reactions and a precursor of cyclic ADP-ribose. β-Nicotinamide adenine dinucleotide reduced dipotassium plays a role as a regenerative electron donor in cellular energy metabolism, including glycolysis, β-oxidation and the tricarboxylic acid (TCA) cycle.

HY-P1548B

β-CGRP, human acetate Human β-CGRP acetate; CGRP-II (Human) (acetate)	CGRP Receptor	Inflammation/Immunology Cardiovascular Disease
β-CGRP, human acetate (Human β-CGRP acetate) is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC₅₀s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells.

HY-113313

Aldosterone	Endogenous Metabolite	Cardiovascular Disease
Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level.

HY-150977

β-Glucuronidase/hCAII-IN-2	Carbonic Anhydrase	Cancer Metabolic Disease Neurological Disease
β-Glucuronidase/hCAII-IN-2 (Compound 12e) is a potent *β-glucuronidase* and hCA II inhibitor with an IC₅₀ of 670.7 μM and 21.77 μM, respectively.

HY-150976

*β-Glucuronidase/hCAII-IN-1*	Carbonic Anhydrase	Cancer Metabolic Disease Neurological Disease
β-Glucuronidase/hCAII-IN-2 (Compound 12e) is a potent *β-glucuronidase* and hCA II inhibitor with an IC₅₀ of 440.1 μM and 4.91 μM, respectively.

HY-N5108

4β,12-Dihydroxyguaian-6,10-diene
Others Others

4β,12-Dihydroxyguaian-6,10-diene, a natural terpene, is isolated from the rhizomes of Alisma orientale.

HY-124265

4β-Hydroxycholesterol	Endogenous Metabolite	Metabolic Disease
4β-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation.

HY-N7683

*Prunetin 5-O-β-D-glucopyranoside*	Glucosidase	Metabolic Disease
Prunetin 5-O-β-D-glucopyranoside is an isoflavone isolated from extracts of Potentilla astracanica. Prunetin 5-O-β-D-glucopyranoside is a potent and uncompetitive inhibitor of α-glucosidase, with an IC₅₀ of 56.05 μg/mL. Prunetin 5-O-β-D-glucopyranoside can be used for the research of type-2 diabetes.

HY-N9525

Limocitrin 3-β-D-glucose
Others Others

Limocitrin 3-β-D-glucose is a flavonoid glycoside.

HY-139303

LUF5771	Others	Endocrinology
LUF5771 is a potent allosteric recombinant luteinizing hormone (recLH) and Org 43553 inhibitor. LUF5771 is able to partially activate the LH receptor with low efficacy.

HY-N8805

Nortrachelogenin-8'-O-β-glucoside	Others	Cancer
Nortrachelogenin-8'-O-β-glucoside is a natural product that can be isolated from the dried roots of Pulsatilla koreana. Nortrachelogenin-8'-O-β-glucoside inhibits cancer cell proliferation and reduces hormone dependence.

HY-151815

beta-Lac-TEG-N3
Others Others

beta-Lac-TEG-N3 is a click chemistry reagent containing an azide group. beta-Lac-TEG-N3 can be used for the research of various biochemical.
HY-N2075

3-Acetyl-beta-boswellic acid
Others Inflammation/Immunology

3-Acetyl-beta-boswellic acid is a boswellic acid isolated from Boswellia serrata gum resin.

HY-P2550

β-Amyloid (1-40), FAM-labeled	Amyloid-β Others	Neurological Disease
β-Amyloid (1-40), FAM-labeled is a FAM fluorescently-labelled β-Amyloid (1-40) peptide (λ_ex= 492 nm and λ_em= 518 nm).

HY-N0171A

Beta-Sitosterol (purity>98%) β-Sitosterol (purity>98%); 22,23-Dihydrostigmasterol (purity>98%)	Apoptosis Endogenous Metabolite	Cancer Inflammation/Immunology Cardiovascular Disease
Beta-Sitosterol (purity>98%) is a plant sterol. Beta-Sitosterol (purity>98%) interfere with multiple cell signaling pathways, including cell cycle, apoptosis, proliferation, survival, invasion, angiogenesis, metastasis and inflammation.

HY-142441

THR-β agonist 1	Others	Endocrinology
THRβ Agonist 1 is a potent and selective agonist of THRβ. Thyroid hormone receptor mediates the physiological activity of thyroid hormones which plays a key role in normal growth and development of the body and in maintaining metabolic balance. THRβ Agonist 1 has the potential for the research of thyroid hormone receptor-related diseases (extracted from patent WO2021104288A1, compound 2).

HY-N10587

Catechin 7-O-β-D-glucopyranoside	Others	Inflammation/Immunology
Catechin 7-O-beta-D-glucopyranoside is an orally active natural product found in Ulmus davidiana and Paeonia obovata. Catechin 7-O-β-D-glucopyranoside shows antioxidant and anti-inflammatory activities, and attenuates mitochondrial dysfunction. Catechin 7-O-beta-D-glucopyranoside can be used in intestinal inflammatory disease research.

HY-P2283

β-Amyloid (1-37) (human)	Amyloid-β	Neurological Disease
β-Amyloid (1-37) (human) correlates moderately with Mini-Mental State Examination (MMSE) scores in Alzheimer disease. β-Amyloid (1-37) (human) possesses an added diagnostic value.

HY-111516

MGV354	Guanylate Cyclase	Inflammation/Immunology Cardiovascular Disease
MGV354 is a soluble guanylate cyclase (sGC) activator with EC₅₀s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively.

HY-151260

AChE/BACE1/GSK3β-IN-1	Beta-secretase Cholinesterase (ChE) GSK-3	Neurological Disease
AChE/BACE1/GSK3β-IN-1 is an orally active triple inhibitor of *AChE/BACE1/GSK3β. AChE/BACE1/GSK3β-IN-1* has effective inhibitory activity against AChE, BACE1 and GSK3β with IC₅₀ values of 1.0 μM, 20 μM and 15 μM, respectively. AChE/BACE1/GSK3β-IN-1 has good blood-brain barrier penetrability, suitable bioavailability. AChE/BACE1/GSK3β-IN-1 can be used for the research of Alzheimer's disease (AD).

HY-N5129

*Genistein 7-O-β-D-glucopyranoside-4'-O-[α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside]*	Others	Others
Genistein 7-O-β-D-glucopyranoside-4'-O-[α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside] is an isoflavone triglycoside that could be isolated from Sophora japonica.

HY-N8143

Emodin-1-O-β-gentiobioside
Others Metabolic Disease

Emodin-1-O-β-gentiobioside is an anthraquinone.

HY-P3781

(Met(O)35)-Amyloid β-Protein (1-42)	Amyloid-β	Neurological Disease
(Met(O)35)-Amyloid β-Protein (1-42) is the oxidation form of Met35 in Aβ42. (Met(O)35)-Amyloid β-Protein (1-42) can yield an oligomer size distribution characteristic of Aβ40. (Met(O)35)-Amyloid β-Protein (1-42) can be used in the research of Alzheimer’s disease (AD).

HY-P2290

Beta-defensin 1, pig	Bacterial	Infection Inflammation/Immunology
Beta-defensin 1, pig is an antimicrobial peptide found primarily in tongue mucosa of pig. Beta-defensin 1, pig is active against bacteria such as *Escherichia coli, Salmonella typhimurium, Listeria monocytogenes, Staphylococcus aureus, Bordetella pertussis* and Candida albicans.

HY-N7598

*Chrysophanol-1-O-β-gentiobioside*	Monoamine Oxidase	Neurological Disease
Chrysophanol-1-O-β-gentiobioside, an anthraquinone glycoside isolated from Cassia obtusifolia seeds. Chrysophanol-1-O-β-gentiobioside shows selective inhibition of hMAO-A isozyme activity (IC₅₀=96.15 μM).

HY-138322

N-trifluoroacetyl-β-alanyl chloride
ADC Linker Cancer

N-trifluoroacetyl-β-alanyl chloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-137940

β-Gentiobiose
Gentiobiose
Others Others

β-Gentiobiose (Gentiobiose) is a naturally occurring oligosaccharin with a rapid turnover rate in ripening tomato fruit.

HY-B0141S4

Estradiol-13C6 β-Estradiol-13C6; E2-13C6; 17β-Estradiol-13C6; 17β-Oestradiol-13C6	Estrogen Receptor/ERR Endogenous Metabolite	Endocrinology Cancer
Estradiol-13C6 (β-Estradiol-13C6) is the 13C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.

HY-B0141S5

Estradiol-13C2 β-Estradiol-13C2; E2-13C2; 17β-Estradiol-13C2; 17β-Oestradiol-13C2	Estrogen Receptor/ERR Endogenous Metabolite	Endocrinology Cancer
Estradiol-13C2 (β-Estradiol-13C2) is the 13C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.

HY-N6986

*Liquiritigenin-7-O-β-D-glucopyranosyl-(1→2)-β-D-apiofuranoside* Liquiritigenin-7-apiosylglucoside	Others	Cancer
Liquiritigenin-7-O-β-D-glucopyranosyl-(1→2)-β-D-apiofuranoside (Liquiritigenin-7-apiosylglucoside) is a flavonoid isolated from the roots of Glycyrrhiza, has weaker cytotoxicity against several tumor cells and normal cells.

HY-N9446S

H-Asn(glcnac-beta-D)-OH-d2
Endogenous Metabolite Others

H-Asn(glcnac-beta-D)-OH-d2 is the deuterium labeled H-Asn(glcnac-beta-D)-OH.

HY-N8102

Echinocystic acid 28-O-β-D-glucoside	Others	Cardiovascular Disease
Echinocystic acid 28-O-β-D-glucoside is a metabolite of Echinocystic acid by microbial oxidation and glucosidation. Echinocystic acid 28-O-β-D-glucoside is a tissue factor pathway inhibitor, with an IC₅₀ of 10.61 nM.

HY-N6677

β-Apo-8'-carotenal Apocarotenal	Cytochrome P450	Cancer
β-Apo-8'-carotenal (Apocarotenal), a provitamin A carotenoid, is an inducer of *CYPlA1* and CYPlA2 in rat. β-Apo-8'-carotenal is present in many fruits and vegetables.

HY-N2929

β-Hydroxypropiovanillone	Glucosidase	Cardiovascular Disease
β-Hydroxypropiovanillone, a natural compound, shows significant concentration-dependent inhibitory effects on α-glucosidase with an IC₅₀ of 257.8 μg/mL.

HY-N1616

1β-Hydroxyeuscaphic acid	Apoptosis	Others
1β-Hydroxyeuscaphic acid has significant hepatoprotective activity by lowering the leakage of intracellular enzymes, reducing the oxidation of proteins and decreasing the incidence of apoptosis.

HY-110189S1

Pregnenolone monosulfate-d4 sodium 3β-Hydroxy-5-pregnen-20-one monosulfate-d4 sodium	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy
Pregnenolone monosulfate-d4 (sodium) is the deuterium labeled Pregnenolone monosulfate. Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication. Pregnenolone monosulfate sodium is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels.

HY-143414

Metallo-β-lactamase-IN-6	Bacterial	Infection
Metallo-β-lactamase-IN-6 is a potent VIM-Type *metallo-β-lactamase* inhibitor with IC₅₀s of 0.56 μM, 29.50 μM and 5.78 μM for VIM-2, VIM-1 and VIM-5. Metallo-β-lactamase-IN-6 displays potent synergistic antibacterial activity with Meropenem against engineered Escherichia coli strains and intractable clinically isolated Pseudomonas aeruginosa producing VIM-2 MBL.

HY-N8163

*Kaempferol-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside*	Others	Others
Kaempferol-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside is an antioxidant with an IC₅₀ of 26.6 μM (DPPH assay).

HY-P2562

β-Amyloid (1-38), mouse, rat	Amyloid-β	Neurological Disease
β-Amyloid (1-38), mouse, rat is composed of 38 aa (1-38 residues of the Aβ peptide) and is the primary component of the amyloid plaques of Alzheimer’s disease.

HY-137553

β-Aminoarteether SM934 free base	NOD-like Receptor (NLR)	Inflammation/Immunology
β-Aminoarteether (SM934 free base) is an Artemisinin derivative with orally active. β-Aminoarteether can be used for inflammation and autoimmune disease research, such as lupus diseases.

HY-144259

Metallo-β-lactamase-IN-2	Bacterial	Infection
Metallo-β-lactamase-IN-4 (compound 40) is a potent metallo-β-lactamases (MBL) inhibitor, with IC₅₀ values of 0.1 μM (VIM-1), 1.3 μM (NDM-1), and 5.0 μM (IMP-7), respectively.

HY-144262

Metallo-β-lactamase-IN-4	Bacterial	Infection
Metallo-β-lactamase-IN-4 (compound 40) is a potent metallo-β-lactamases (MBL) inhibitor, with IC₅₀ values of 0.5 μM (VIM-1), 2.1 μM (NDM-1), and 3.3 μM (IMP-7), respectively.

HY-N0406

*2"-O-beta-L-galactopyranosylorientin*	Others	Inflammation/Immunology
2"-O-beta-L-galactopyranosylorientin is extracted from the flowers of Trollius ledebouri. 2"-O-beta-L-galactopyranosylorientin involves transporter mediated efflux in addition to passive diffusion and is the substrate of multidrug resistance protein 2 (MRP2). Anti-inflammatory effect.

HY-151201

Steroid sulfatase/17β-HSD1-IN-3	Others	Cancer
Steroid sulfatase/17β-HSD1-IN-3 (compound 19) is a dual inhibitor of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1 (17β *HSD1). Steroid sulfatase/17β-HSD1-IN-3* irreversibly inhibits hSTS activity with anIC₅₀ value of 27 nM. Steroid sulfatase/17β-HSD1-IN-3 can be used in the study of endometriosis and other estrogen-dependent diseases.

HY-151202

Steroid sulfatase/17β-HSD1-IN-4	Others	Cancer
Steroid sulfatase/17β-HSD1-IN-4 (compound 37) is a dual inhibitor of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1 (17β *HSD1). Steroid sulfatase/17β-HSD1-IN-4* irreversibly inhibits hSTS activity with anIC₅₀ value of 63 nM. Steroid sulfatase/17β-HSD1-IN-4 can be used in the study of endometriosis and other estrogen-dependent diseases.

HY-139413

β-D-Glucan	Toll-like Receptor (TLR)	Cancer
β-D-glucan is a natural non-digestible polysaccharide and high biocompatibility that can be selectively recognized by recognition receptors such as Dectin-1 and Toll-like receptors as well as being easily internalized by murine or human macrophages, which is likely to attribute to a target delivery. β-d-glucan is an enteric delivery vehicle for probiotics.

HY-N4201

β-Hydroxyisovalerylshikonin	EGFR Src	Cancer
Beta-hydroxyisovalerylshikonin is a natural product isolated from Lithospermum erythrorhizon, acts as a potent inhibitor of protein tyrosine kinases (PTK), with IC₅₀s of 0.7μM and 1μM for EGFR and v-Src receptor, respectively. Beta-hydroxyisovalerylshikonin is effective against a wide variety of tumor cell lines, and most efficiently induces cell-death in NCI-H522 and DMS114 cells.

HY-139733

β-N-Acetyl-D-hexosaminidase-IN-1
Others Others

β-N-Acetyl-D-hexosaminidase-IN-1 is a novel β-N-acetyl-d-hexosaminidase inhibitor with a K_i value of 3.72 μM.
HY-139720

β-Secretase Inhibitor III
Beta-secretase Neurological Disease

β-Secretase Inhibitor III is an extremely selective BACE1 inhibitor (K_i = 0.13 nM).
HY-N10525

3α,4β-Galactotriose
Others Others

3α,4β-Galactotriose is a galactosyl residue.
HY-N5094

6'-O-β-Apiofuranosylsweroside
Others Others

6'-O-β-Apiofuranosylsweroside is a secoiridoid glycoside that can be isolated from the leaves of Lonicera angustifolia Wall.

HY-N3523

*3-O-Beta-D-Glucopyranosylplatycodigenin*	Others	Cancer
3-O-Beta-D-Glucopyranosylplatycodigenin is an oleanane-type triterpenoid isolated from roots of Platycodon grandiflorum. 3-O-Beta-D-Glucopyranosylplatycodigenin exhibits anti-proliferative activities against HSC-T6 cell line with an IC₅₀ of 13.36 μM.

HY-N8126

Emodin 6-O-β-D-glucoside Glucoemodin	Others	Metabolic Disease Inflammation/Immunology
Emodin-6-O-β-D-glucoside (Glucoemodin) is an active compound from Reynoutria japonica. Emodin-6-O-β-D-glucoside shows potent anti-inflammatory and barrier protective effects. Emodin-6-O-β-D-glucoside can be used for the research of diabetic complications and atherosclerosis.

HY-151199

Steroid sulfatase/17β-HSD1-IN-1	Others	Cancer Endocrinology
Steroid sulfatase/17β-HSD1-IN-1 is a potent steroid sulfatase and 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) inhibitor with an IC₅₀ value of 28 nM for cellular human steroid sulfatase. Steroid sulfatase/17β-HSD1-IN-1 can be used to research estrogen-dependent diseases.

HY-N2287

Cimifugin 4'-O-β-D-glucopyranoside
Others Inflammation/Immunology

Cimifugin 4'-O-β-D-glucopyranoside is a derivative of cimifugin.

HY-145736

β-Glucuronide-dPBD-PEG5-NH2	Drug-Linker Conjugates for ADC Apoptosis	Cancer
β-Glucuronide-dPBD-PEG5-NH2 is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD. β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2, as a prodrug of cIRCR201-dPBD, reduces side effects. β-Glucuronide-dPBD-PEG5-NH2 can induce apoptosis and arrest cell cycle. β-Glucuronide-dPBD-PEG5-NH2 has antitumor activity.

HY-114392

Gly-β-MCA	FXR Autophagy	Metabolic Disease
Gly-β-MCA, a bile acid, is a potent, sable, intestine-selective and oral bioactive farnesoid X receptor (FXR) inhibitor that may be a candidate for the treatment of metabolic disorders.

HY-20696

Tetrahydro-β-carboline Tryptoline	5-HT Receptor	Metabolic Disease
Tetrahydro-β-carboline (Tryptoline) is a metabolite of tryptamine, also is a competitive serotonin reuptake inhibitor with an K_i value of 6.1 µM.

HY-P0265

β-Amyloid (1-40)
Amyloid-β Neurological Disease

β-Amyloid (1-40) is a primary protein in plaques found in the brains of patients with Alzheimer's disease.

HY-N6006

1,3,6-Tri-O-galloyl-beta-D-glucose 1,3,6-Tri-O-galloyl-β-D-glucose	Others	Others
1,3,6-Tri-O-galloyl-beta-D-glucose (1,3,6-Tri-O-galloyl-β-D-glucose) is a phenolic compound in Black Walnut Kernels.

HY-112023

Lumisterol 3 (>90%) 9β,10α-Cholesta-5,7-dien-3β-ol; Cholecalciferol EP Impurity C	Endogenous Metabolite	Metabolic Disease
Lumisterol 3 (>90%) (9β,10α-Cholesta-5,7-dien-3β-ol) is a normal human secosterooid metabolite from the class of vitamin D3 photoisomer derivatives. Lumisterol 3 (>90%) is used in the preparation of vitamin D.

HY-107231

Xanthiside
Xanthiazone O-β-D-glucoside
Others Others

Xanthiside (Xanthiazone O-β-D-glucoside) is a heterocyclic glucoside.

HY-N7661

4β-Hydroxywithanolide E	PPAR	Metabolic Disease
4β-Hydroxywithanolide E, isolated from Physalis peruviana L., inhibits adipocyte differentiation of 3T3-L1 cells through modulation of mitotic clonal expansion. 4β-Hydroxywithanolide E is an adipogenesis inhibitor and inhibits PPARγ, C/EBPα, and the adipocyte-specific molecule aP2 mRNA expression.

HY-W353804

2′-Deoxy-β-L-uridine	Nucleoside Antimetabolite/Analog	Infection
2'-Deoxy-β-L-uridine is a nucledside analogue and a specific substrate for the viral enzyme, shows no stereospecificity against herpes simplex 1 (HSV1) thymidine kinase (TK). 2′-Deoxy-β-L-uridine exerts antiviral activity via the interation of 5'-triphosphates with the viral DNA polymerase.

HY-114981

SRTCX1002	Sirtuin	Inflammation/Immunology
SRTCX1002 is a potent activator of *SIRT1* (STAC), suppresses inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB Activity. SRTCX1002 suppresses stimuli-induced NF-κB transcriptional activation and LPS-induced TNFα secretion with IC₅₀s of 0.71 and 7.58 µM, respectively.

HY-15870

SR 11302	AP-1	Cancer Inflammation/Immunology
SR 11302 is an **activator protein-1** (AP-1) transcription factor inhibitor. SR 11302 is a retinoid that specifically inhibits AP-1 activity without activating the transcription of retinoic acid response element (RARE).

HY-100084

Methyl-3β-hydroxycholenate
ROR Inflammation/Immunology

Methyl-3β-hydroxycholenate is a ROR gamma modulator extracted from patent US20110263046 A1, in figure 2.

HY-103349

PETCM	Caspase Apoptosis	Cancer
PETCM is an activator of caspase-3 and acts as an cytochrome c (cyto c)-dependent manner. PETCM promotes Apaf-1 oligomerization and induces cell apoptosis in HeLa cells.

HY-136306

Metallo β-lactamase ligand 1	Bacterial	Infection
Metallo-beta-lactamase ligand 1 is a class B *β-lactamase* inhibitor with antibacterial activity extracted from patent WO2019221122A1, compound A.

HY-W015546

β-N-methylamino-L-alanine hydrochloride BMAA hydrochloride	Others	Neurological Disease
β-N-methylamino-L-alanine hydrochloride (BMAA hydrochloride) is a neurotoxin produced by cyanobacteria. β-N-methylamino-L-alanine hydrochloride could cause amyotrophic lateral sclerosis (ALS) and possibly other neurodegenerative diseases.

HY-N9322

Bergaptol O-β-D-glucopyranoside
Others Cancer

Bergaptol O-β-D-glucopyranoside possesses anti-gastric ulcer and anti-cancer effect.
HY-15679

PI4KIII beta inhibitor 3
PI4K Cancer

PI4KIII beta inhibitor 3 is a novel and high effective PI4KIIIβ inhibitor with IC₅₀ of 5.7 nM.
HY-N6911

Licorice-saponin H2
(18β,20α)-Glycyrrhizic acid
Others Metabolic Disease

Licorice-saponin H2 ((18β,20α)-Glycyrrhizic acid) is a saponin from Glycyrrhiza uralensis Fischer.

HY-N5091

Physcion 8-O-β-D-glucopyranoside	Others	Cancer Inflammation/Immunology
Physcion 8-O-β-D-glucopyranosideis an anthraquinone compound isolated from Rumex japonicus Houtt. Physcion 8-O-β-D-glucopyranoside exerts anti-inflammatory and anti-cancer properties, can be for common malignancy cancer research.

HY-N9615

Azadiradione	HSP	Infection Inflammation/Immunology Neurological Disease
Azadiradione is a bioactive limonoid found in Azadirachta indica. Azadiradione is a *HSF1* activator. Azadiradione has antimycobacterial, anti-nociceptive and anti-inflammatory activities.

HY-P0265A

β-Amyloid (1-40) (TFA) Amyloid beta-Peptide (1-40) (human) TFA; Amyloid β-Peptide (1-40) (human) TFA	Amyloid-β	Neurological Disease
β-Amyloid (1-40) TFA is a primary protein in plaques found in the brains of patients with Alzheimer's disease.

HY-P1548A

β-CGRP, human TFA Human β-CGRP TFA; CGRP-II (Human) (TFA)	CGRP Receptor	Inflammation/Immunology Cardiovascular Disease
β-CGRP, human TFA (Human β-CGRP TFA) is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC₅₀s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells.

HY-B0141

Estradiol β-Estradiol; E2; 17β-Estradiol; 17β-Oestradiol	Estrogen Receptor/ERR Endogenous Metabolite Bacterial	Endocrinology Cancer
Estradiol (β-Estradiol) is a steroid hormone and the major female sex hormone. Estradiol can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering.

HY-P3343A

hFSH-β-(33-53) (TFA)	Estrogen Receptor/ERR	Cancer
hFSH-β-(33-53) TFA, a thiol-containing peptide which corresponds to a second FSH receptor-binding domain, is a FSHR (follicle-stimulating hormone receptor) antagonist. hFSH-β-(33-53) TFA inhibits binding of FSH to receptor and is a partial agonist of estradiol synthesis in Sertoli cells.

HY-N0520

Calycosin-7-O-β-D-glucoside	Reactive Oxygen Species	Others
Calycosin-7-O-β-D-glucoside is an isoflavone isolated from Astragali Radix. Calycosin-7-O-β-D-glucoside has variety of biological activities, such as neuroprotective, cardioprotection, anti-inflammation, and antioxidative stress effects.

HY-117917

(Rac)-MGV354	Guanylate Cyclase	Inflammation/Immunology Cardiovascular Disease
(Rac)-MGV354 is the racemate of MGV354. MGV354 is a soluble guanylate cyclase (sGC) activator with EC₅₀s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively.

HY-16785

Veledimex INXN-1001; RG-115932	Interleukin Related	Cancer Inflammation/Immunology
Veledimex (INXN-1001), a synthetic analog of the insect molting hormone ecdysone, is an orally active activator ligand for a proprietary gene therapy promoter system. Veledimex can be used to activate certain genes using the ecdysone receptor (EcR)-based inducible gene regulation system, the RheoSwitch Therapeutic System (RTS). Veledimex can cross blood-brain barrier (BBB) in both orthotopic GL-261 mice and cynomolgus monkeys.

HY-138247

β-Lactamase-IN-2 EX-A4764; UUN51204	Bacterial Antibiotic	Infection
β-Lactamase-IN-2 is a *beta-lactamase* inhibitor, extracted from patent WO 2019075084 A1, compound 1. β-Lactamase-IN-2 has anti-microbial and anti-bacterial effects.

HY-N10371

Physcion-8-O-β-gentiobioside
Others Others

Physcion-8-O-β-gentiobioside is an anthraquinone glycoside isolated from rhubarb roots.

HY-N10227

Geodin	PAI-1 Antibiotic	Infection Inflammation/Immunology
Geodin, a fungal metabolite, shows antibacterial activity. Geodin also is an inhibitor of plasminogen activator inhibitor- 1 (PAI-1).

HY-100740C

*(1α,1'S,4β)-Lanabecestat* (1α,1'S,4β)-AZD3293; (1α,1'S,4β)-LY3314814	Beta-secretase	Neurological Disease
(1α,1'S,4β)-Lanabecestat ((1α,1'S,4β)-AZD3293) a less active enantiomer of Lanabecestat. Lanabecestat is a potent, orally active and blood-brain barrier penetrating BACE1 inhibitor with a K_i of 0.4 nM.

HY-13856

(R)-PS210	PDK-1	Cancer
(R)-PS210, the R enantiomer of PS210 (compound 4h-eutomer), is a substrate-selective allosteric activator of *PDK1* with an AC₅₀ value of 1.8 μM. (R)-PS210 targets to the PIF-binding pocket of PDK1. PIF: The protein kinase C-related kinase 2 (PRK2)-interacting fragment.

HY-124702

ICA-105574	Potassium Channel	Cardiovascular Disease
ICA-105574 is a potent and efficacious hERG channel activator. The primary mechanism by which ICA-105574 potentiates hERG channel activity is by removing hERG channel inactivation. ICA-105574 steeply potentiates current amplitudes more than 10-fold with an EC₅₀ value of 0.5 +/- 0.1 μM and a Hill slope (n(H)) of 3.3 +/- 0.2.

HY-N0087

Gambogic Acid beta-Guttiferrin	Bcl-2 Family Autophagy	Cancer
Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits Bcl-X_L, Bcl-2, Bcl-W, Bcl-B, *Bfl-1* and *Mcl-1* with IC₅₀s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.

HY-145736A

β-Glucuronide-dPBD-PEG5-NH2 TFA	Drug-Linker Conjugates for ADC Apoptosis	Cancer
β-Glucuronide-dPBD-PEG5-NH2 TFA is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD.β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2 TFA, as a prodrug of cIRCR201-dPBD, reduces side effects. β-Glucuronide-dPBD-PEG5-NH2 TFA can induce apoptosis and arrest cell cycle. β-Glucuronide-dPBD-PEG5-NH2 TFA has antitumor activity.

HY-W050145

Levoglucosan 1,6-Anhydro-β-D-glucopyranose; 1,6-Anhydro-β-D-glucose	Endogenous Metabolite	Metabolic Disease
Levoglucosan (1,6-Anhydro-β-D-glucopyranose) is an anhydrosugar produced through glucan pyrolysis and is widely found in nature.

HY-144329

STING agonist-11	STING	Inflammation/Immunology Cancer
STING agonist-11 (Compound 92) is a potent small molecule cyclic urea activator of STING with EC₅₀ of 18 nM. Activation of STING is a highly promising approach in immunotherapy.

HY-144328

STING agonist-10	STING	Inflammation/Immunology Cancer
STING agonist-10 (Compound 91) is a potent small molecule cyclic urea activator of STING with the EC₅₀ of 2600 nM. Activation of STING is a highly promising approach in immunotherapy.

HY-N7957

Pratensein-7-O-β-D-glucopyranoside
Others Others

Pratensein-7-O-β-D-glucopyranoside is a new isoflavone.

HY-N10378

Rubrofusarin 6-O-β-D-glucopyranoside	Phosphatase	Metabolic Disease Neurological Disease
Rubrofusarin 6-O-β-D-glucopyranoside, the glycoside of Rubrofusarin, is a protein tyrosine phosphatase 1B (PTP1B) inhibitor with the IC₅₀ of 87.36 μM. Rubrofusarin 6-O-β-D-glucopyranoside can be used for the research of comorbid diabetes and depression.

HY-P2290A

Beta-defensin 1, pig TFA	Bacterial	Infection Inflammation/Immunology
Beta-defensin 1, pig TFA is an antimicrobial peptide found primarily in tongue mucosa of pig. Beta-defensin 1, pig TFA is active against bacteria such as *Escherichia coli, Salmonella typhimurium, Listeria monocytogenes, Staphylococcus aureus, Bordetella pertussis* and Candida albicans.

HY-N9000

Loganic acid 6′-O-β-D-glucoside	TNF Receptor	Inflammation/Immunology
Loganic acid 6′-O-β-D-glucoside, a iridoidal glucoside, is isolated from the whole plant of Gentiana rhodantha (Gentianaceae). Loganic acid 6′-O-β-D-glucoside inhibits LPS-induced NO and TNF-α production in macrophage RAW264.7 cells.

HY-137276

5-Bromo-3-indolyl β-D-galactopyranoside Bluo-Gal	Others	Others
5-Bromo-3-indolyl β-D-galactopyranoside (Bluo-Gal) is a chromogenic substrate to detect bacterial β-D-galactosidase activity. 5-Bromo-3-indolyl β-D-galactopyranoside is used both to recognize labelled myofibers, and beta-gal positive organelles inside single myofibers.

HY-141490

Beta-D-Glucopyranosyl nitromethane	Others	Others
Beta-D-Glucopyranosyl nitromethane, as a salt of a strongly basic anion exchanger in the OH cycle, is a glycosyl derivative of nitromethane.

HY-139671

Ultrashort α,β-Peptide
Others Others

Ultrashort α,β-Peptide is found to be able to stabilize colloidal gold nanoparticles in physiological media over 3 months.

HY-P2313

Human β-defensin-2 HβD-2	Antibiotic Bacterial	Infection
Human β-defensin-2 (HβD-2) is a small cysteine-rich cationic skin-antimicrobial peptide (SAP) produced by a number of epithelial cells.Human β-defensin-2 has antimicrobial activity against gram-negative bacteria and Candida, but not gram-positive Staphylococcus aureus. Human β-defensin-2 can be used for the study of colitis.

HY-N10411

Morin 3-O-β-D-glucopyranoside	Reverse Transcriptase HIV Xanthine Oxidase	Cancer Infection Cardiovascular Disease
Morin 3-O-β-D-glucopyranoside is a natural flavonoid with antifungal, anticancer and antioxidant activities. Morin 3-O-β-D-glucopyranoside inhibits reverse transcriptase, protein-tyrosine kinase and xanthine oxidase, and also shows anti-HIV, antiarteriosclerotic, and superoxide scavenging activities.

HY-N6885

Puerarin-4'-O-β-D-glucopyranoside	Others	Cancer
Puerarin-4'-O-β-D-glucopyranoside (compound 8) is a isoflavone from Pueraria lobata root (PLR). Puerarin-4'-O-β-D-glucopyranoside has estrogenic activity and anti-proliferation of MCF-7 human breast carcinoma cells.

HY-50900

gamma-Secretase Modulators Amyloid-β production inhibitor; γ-Secretase Modulators	Amyloid-β	Neurological Disease
gamma-Secretase Modulators (Amyloid-β production inhibitor) is a Amyloid-β production inhibitor.

HY-B0141S6

Estradiol-d2-1 β-Estradiol-d2-1; E2-d2-1; 17β-Estradiol-d2-1; 17β-Oestradiol-d2-1	Estrogen Receptor/ERR Endogenous Metabolite	Inflammation/Immunology Neurological Disease
Estradiol-d2-1 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.

HY-B1427

Gamibetal Gamma-amino-beta-hydroxybutyric acid	Endogenous Metabolite	Neurological Disease
Gamibetal is the gamma-amino-beta-hydroxybutyric acid. Gamibetal has the potential for the research of epilepsy.

HY-N9408

Furostan, β-D-glucopyranoside deriv
Others Others

Furostan, β-D-glucopyranoside deriv (compound 2) is a oligofurostanoside that can be found in Asparagus cochinchinensis.
HY-N6938

Pseudolaric acid B β-D-glucoside
Others Infection

Pseudolaric acid B β-D-glucoside is a diterpenoid isolated from Pseudolarix kaempferi.

HY-137853

4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-Glucopyranoside	Others	Others
4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-Glucopyranoside is a fluorogenic substrate for N-acetyl-β-D-glucosaminidase.

HY-142119S

5-Hydroxy tryptophol β-D-glucuronide-d4
mAChR NF-κB Others Others

5-Hydroxy tryptophol β-D-glucuronide-d4 is the deuterium labeled 5-Hydroxy tryptophol β-D-glucuronide.

HY-N9372

Crocetin β-D-glucopyranoside	Others	Cancer Neurological Disease Cardiovascular Disease
Crocetin β-D-glucopyranoside is an active part of saffron pigments extracted from patent CN 105935363 A.

HY-N9009

1-Hydroxymethyl-β-carboline glucoside
Others Others

1-Hydroxymethyl-β-carboline glucoside (Compound 13) is a natural product that can be isolated from Picrasma quassioides.
HY-N6630

6-Methylflavone
GABA Receptor Neurological Disease

6-Methylflavone is an activator of α₁β₂γ_2L and α₁β₂ GABA_A receptors.

HY-P1430

11R-VIVIT	Nuclear Factor of activated T Cells (NFAT)	Metabolic Disease
11R-VIVIT is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. 11R-VIVIT can be used for the research of podocyte and diabetic nephropathy.

HY-113261

Oleoylcarnitine	Endogenous Metabolite	Cancer Metabolic Disease
Oleoylcarnitine, the metabolite which accumulates through suppression of fatty acid β-oxidation, can enhance hepatocarcinogenesis via STAT3 activation.

HY-N6879

DiosMetin 7-O-β-D-Glucuronide
Others Metabolic Disease

DiosMetin 7-O-β-D-Glucuronide is an antioxidant constituent in the fruits of Luffa cylindrical.
HY-N6260

4-O-beta-Glucopyranosyl-cis-coumaric acid
Others Others

4-O-beta-Glucopyranosyl-cis-coumaric acid is a natural compound isolated formn Nelumbo nucifera Gaertn.

HY-N8132

*2,4,6-Trichlorol-3-methyl-5-methoxy-phenol 1-O-β-d-glucopyranosyl-(1* → 6)-β-d-glucopyranoside**	Reactive Oxygen Species	Inflammation/Immunology
2,4,6-Trichlorol-3-methyl-5-methoxy-phenol 1-O-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside is a chlorophenyl glycoside found in the bulbs of Lilium brownie var. viridulum. 2,4,6-Trichlorol-3-methyl-5-methoxy-phenol 1-O-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside exhibits weak inhibition of NO production in LPS-stimulated RAW 264.7 cells.

HY-43470

3α,12β-Dihydroxycholanoic acid
Endogenous Metabolite Metabolic Disease

3α,12β-Dihydroxycholanoic acid is a bile acid that can be isolated from urine specimens of healthy humans.

HY-136344

Simvastatin Acyl-β-D-glucuronide	Drug Metabolite	Others
Simvastatin Acyl-β-D-glucuronide is a metabolite of Simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase with a K_i of 0.2 nM.

HY-N1626

1β-Hydroxy-2-oxopomolic acid
Others Others

1β-Hydroxy-2-oxopomolic acid is a compound isolated from methanolic extract of leaves of Eriobotrya deflexa.
HY-N2054

Kaempferol 4'-glucoside
Kaempferol 4'-β-glucoside
Others Others

Kaempferol 4'-glucoside (Kaempferol 4'-β-glucoside) is a flavonol glycoside.

HY-N10441

3β-Hydroxy-hop-22(29)-ene	Parasite	Infection
3β-Hydroxy-hop-22(29)-ene (compound 3) is a potent antiparasitic agent. 3β-Hydroxy-hop-22(29)-ene shows moderate activity against Trypanosoma cruzi and Leishmania mexicana.

HY-145781

β-L-Fucopyranosyl phosphate	Others	Metabolic Disease
β-L-Fucopyranosyl phosphate can be used for the research of carbohydrate metabolism. Glycosyl phosphates play crucial roles in carbohydrate metabolism as metabolic regulators or ubiquitous intermediates for glycoconjugate biosynthesis.

HY-N0803

Myrcene
β-Myrcene
NF-κB Others

Myrcene (β-Myrcene), an aromatic volatile compound, suppresses TNFα-induced NF-κB activity. Myrcene has anti-invasive effect.

HY-N1646

2,16-Kauranediol 2-O-β-D-allopyranoside 2β,16α-dihydroxy-ent-kaurane 2-O-β-D-allopyranoside	Others	Others
2,16-Kauranediol 2-O-β-D-allopyranoside (compound 26) is a natural product that can be isolated from the air-dried fronds of Pteris cretica.

HY-138936

SSK1	p38 MAPK Apoptosis	Inflammation/Immunology
SSK1, a senescence-specific killing compound, is a β-galactosidase-targeted prodrug attenuates inflammation. SSK1 is activated by lysosomal β-galactosidase and selectively killed senescent cells through the activation of p38 MAPK and induction of *apoptosis*.

HY-137823

4-Nitrophenyl-N-acetyl-β-D-galactosaminide	Endogenous Metabolite	Cancer
4-Nitrophenyl-N-acetyl-β-D-galactosaminide has inhibitory activity against GlcNAc and GalNAc with K_is of 1.15 mM and 0.51 mM, respectively. 4-Nitrophenyl-N-acetyl-β-D-galactosaminide is extracted from Trichomonas foetus (T. foetus)

HY-P1866

β-Endorphin, equine	Opioid Receptor	Neurological Disease
β-Endorphin, equine is an endogenous opioid peptide, which binds at high affinity to both μ/δ opioid receptors. Analgesic properties.

HY-N8971

Bauer-7-ene-3β,16α-diol 16α-Hydroxybauerenol	Bacterial	Infection
Bauer-7-ene-3β,16α-diol, a triterpenoid, is a natural product that can be isolated from dried flower buds of Tussilago farfara L. or Petasites tricholobus (Compositae). Bauer-7-ene-3β,16α-diol shows medium antibacterial activity against E. coli.

HY-145519

Mu-6S-Palm-β-Glc	Others	Neurological Disease
Mu-6S-Palm-β-Glc is a fluorogenic substrate for palmitoyl-protein thioesterase (PPT). Mu-6S-Palm-β-Glc can be used for the research of neuronal ceroid lipofuscin disease in infants.

HY-128974

N-Dodecyl-β-D-maltoside Lauryl Maltoside	Others	Others
N-Dodecyl-β-D-maltoside (Lauryl Maltoside) is a derivatives of pyrene (Py), and it is a alkyl maltopyranoside detergent, especially in transporters and respiratory complexes. N-Dodecyl-β-D-maltoside has also been employed in applications such as in the purification and stabilization of RNA polymerase and detection of protein-lipid interactions.

HY-P1430A

11R-VIVIT TFA	Nuclear Factor of activated T Cells (NFAT)	Metabolic Disease
11R-VIVIT TFA is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. 11R-VIVIT TFA can be used for the research of podocyte and diabetic nephropathy.

HY-P2291

Beta-defensin 103 isoform X1, pig	Bacterial	Inflammation/Immunology
Beta-defensin 103 isoform X1, pig is an antimicrobial peptide found in different living organisms, involved in the first line of defense in their innate immune response against pathogens.

HY-N8204

Siaresinolic acid 28-O-β-D-glucopyranosyl ester	Others	Cancer Metabolic Disease
Siaresinolic acid 28-O-β-D-glucopyranosyl ester possesses anti-tumor and antidiabetic effect activity.

HY-N4088

Pseudolaric acid A-O-β-D-glucopyranoside	Fungal	Infection Endocrinology
Pseudolaric acid A-O-β-D-glucopyranoside, isolated from Cortex Pseudolaricis, demonstrates antifungal and antifertility activities.

HY-129987

Estradiol 17-(β-D-Glucuronide) (sodium)	Endogenous Metabolite	Endocrinology Metabolic Disease
Estradiol 17-(β-D-Glucuronide) sodium, a metabolite of estrogen, is well known to cause intrahepatic cholestasis in humans.

HY-19121A

TCV-309 chloride	Platelet-activating Factor Receptor (PAFR)	Cancer
TCV-309 chloride is a potent and specific *platelet activating* factor (PAF) antagonist. TCV-309 chloride specifically inhibits PAF-induced aggregation of rabbit and human platelets, and [3H]PAF binding to rabbit platelet microsomes with IC₅₀** values of 33 nM, 58 nM and 27 nM, respectively. TCV-309 chloride has beneficial effects in anaphylactic shock.

HY-B1192

Estradiol benzoate β-Estradiol 3-benzoate; 17β-Estradiol 3-benzoate	Estrogen Receptor/ERR	Endocrinology Cancer
Estradiol Benzoate (β-Estradiol 3-benzoate), a prodrug of estradiol, acts as a steroid sex hormone. It exhibits mild anabolic and metabolic properties, and increases blood coagulability.

HY-N7898

Epipinoresinol-4'-O-β-D-glucoside
Simplocosin
Others Others

Epipinoresinol-4'-O-β-D-glucoside (Simplocosin) is a glucoside compound.

HY-N0230

β-Alanine 2-Carboxyethylamine; 3-Aminopropanoic acid	Endogenous Metabolite	Metabolic Disease
β-Alanine is a non-essential amino acid that is shown to be metabolized into carnosine, which functions as an intracellular buffer.

HY-111642

3'-Azido-3'-deoxy-beta-L-uridine
Nucleoside Antimetabolite/Analog Others

3'-Azido-3'-deoxy-beta-L-uridine (Compound 25) is a nucleoside derivative.

HY-P1894

β-Amyloid Protein Precursor 770 (135-155)	Amyloid-β	Neurological Disease
β-Amyloid Protein Precursor 770 (135-155) is a peptide of amyloid precursor protein isoform (APP 770). APP 770 produces Aβ40/42.

HY-109897

CV-6209	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
CV-6209 is a potent antagonist of *platelet activating* factor (PAF). CV-6209 inhibits the PAF-induced aggregation of rabbit and human platelets, with IC₅₀*s of 75 nM and 170 nM, respectively. CV-6209 can inhibit PAF-induced hypotension in rats.*

HY-N9452

Capsaicin β-D-glucopyranoside	Others	Others
Capsaicin β-D-glucopyranoside is a glucoside converted by Capsaicin. Capsaicin is the active ingredient of chili peppers and gives them the characteristic pungent flavor.

HY-135103

Tauro-β-muricholic acid sodium T-βMCA sodium	FXR	Cancer
Tauro-β-muricholic Acid sodium (T-βMCA sodium), a endogenous metabolite, is a competitive and reversible farnesoid X receptor (FXR) antagonist, with an IC₅₀ of 40 μM.

HY-W010452

3-Hydroxybutyric acid sodium β-Hydroxybutyric acid sodium	Endogenous Metabolite	Metabolic Disease
3-Hydroxybutyric acid sodium (β-Hydroxybutyric acid sodium) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid sodium can modulate the properties of membrane lipids.

HY-113378

3-Hydroxybutyric acid β-Hydroxybutyric acid	Endogenous Metabolite	Metabolic Disease
3-Hydroxybutyric acid (β-Hydroxybutyric acid) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid can modulate the properties of membrane lipids.

HY-101804

(E)-Alprenoxime
CDDD-1815
Others Cardiovascular Disease

(E)-Alprenoxime is the isomer of the Alprenoxime. Alprenoxime is a site-activated ocular β-blocker.
HY-N9380

Luteolin-7-O-β-D-glucopyranoside
Others Cardiovascular Disease

Luteolin-7-O-β-D-glucopyranoside is one of the chemical constituents of the aerial parts of codonopsis nervosa.

HY-U00250

β-Amino Acid Imagabalin Hydrochloride PD-0332334	Calcium Channel	Neurological Disease
β-Amino Acid Imagabalin Hydrochloride (PD-0332334) is a ligand for the α2δ subunit of the voltage-dependent calcium channel.

HY-N2107

Physion 8-O-β-D-glucoside	Others	Neurological Disease Cardiovascular Disease
Physion 8-O-β-D-glucoside, a bioactive component of Fallopia multiflora, can be used for the research of dizziness.

HY-136329

β-D-glucuronide-pNP-carbonate
ADC Linker Cancer

β-D-glucuronide-pNP-carbonate is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-151196

FXIa-IN-10
Others Cardiovascular Disease

FXIa-IN-10 (Compound 3f) is a potent activated factor XI (FXIa) inhibitor with an K_i of 0.17 nM. FXIa-IN-10 has good oral bioavailability.

HY-141464

*Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OH* Fmoc-Asn(Ac3AcNH-beta-Glc)-OH	Others	Cancer
Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OH (Fmoc-Asn(Ac3AcNH-beta-Glc)-OH) can be used in the synthesis of silicon-fluoride acceptor (SiFA) derivatized octreotate derivatives. SiFA-octreotate analogues, as tumor imaging agents, are useful tool for the research of positron emission tomography (PET).

HY-P2312

Human β-defensin-3 HβD-3	Antibiotic Bacterial	Infection
Human β-defensin-3 (HβD-3) is an antibiotic anti-microbial peptide produced by epithelial cells with antimicrobial activities and reduces the effect of inflammatory cytokine responses. Human β-defensin-3 is against different microbes with IC₉₀ values of 6-25 μg/ml.

HY-P3780

Cys-Gly-Lys-Lys-Gly-Amyloid β-Protein (36-42)	Amyloid-β	Neurological Disease
Cys-Gly-Lys-Lys-Gly-Amyloid β-Protein (36-42) is the 36-42 fragment of Amyloid β-Protein. β-amyloid, a polypeptide made up of 36-43 amino acids, is the main component of amyloid plaques found in the brains of people with Alzheimer's disease. β-amyloid oligomers (Aβos) plays A key role in the progression of Alzheimer's disease (AD) by inducing neuronal damage and cognitive impairment.

HY-A0058

Retinyl glucoside Retinyl β-D-glucoside	Others	Metabolic Disease
Retinyl-β-D-glucoside is a naturally occurring and biologically active metabolites of vitamin A, which are found in fish and mammals.

HY-P1504

β-Melanocyte Stimulating Hormone (MSH), human beta-MSH (1-22) (human)	Melanocortin Receptor	Metabolic Disease Neurological Disease Endocrinology
β-Melanocyte Stimulating Hormone (MSH), human, a 22-residue peptide, acts as an endogenous melanocortin-4 receptor (MC4-R) agonist.

HY-141131

Propargyl-PEG2-beta-D-glucose
PROTAC Linkers Cancer

Propargyl-PEG2-beta-D-glucose is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-141132

Propargyl-PEG4-beta-D-glucose
PROTAC Linkers Cancer

Propargyl-PEG4-beta-D-glucose is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-N10647

Isoscutellarein 8-O-β-D-glucuronide
Others Inflammation/Immunology

Isoscutellarein 8-O-β-D-glucuronide is a flavonoid antioxidant, can be isolated from Theobroma grandiflorum seeds.
HY-140012

Azido-PEG4-beta-D-glucose
PROTAC Linkers Cancer

Azido-PEG4-beta-D-glucose is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-P2315

Human β-defensin-1 HβD-1	Antibiotic Bacterial	Infection
Human β-defensin-1 (HβD-1) is a cysteine-rich cationic skin-antimicrobial peptide (SAP) produced by all epithelial surfaces, but also by circulatory cells and cells of the reproductive tract. Human β-defensin-1 has antimicrobial activities against a broad-sperm bacteria.

HY-113320

Etiocholanolone 5β-Androsterone	GABA Receptor Endogenous Metabolite	Neurological Disease
Etiocholanolone (5β-Androsterone) is the excreted metabolite of testosterone and has anticonvulsant activity. Etiocholanolone is a less potent neurosteroid positive allosteric modulator (PAM) of the GABA_A receptor than its enantiomer form.

HY-P1388

β-Amyloid (1-42), (rat/mouse) Amyloid β-peptide (1-42) (rat/mouse)	Amyloid-β	Neurological Disease
β-Amyloid (1-42), (rat/mouse) is a 42-aa peptide, shows cytotoxic effect on acute hippocampal slices, and used in the research of Alzheimer's disease.

HY-P2291A

Beta-defensin 103 isoform X1, pig TFA	Bacterial	Inflammation/Immunology
Beta-defensin 103 isoform X1, pig TFA is an antimicrobial peptide found in different living organisms, involved in the first line of defense in their innate immune response against pathogens.

HY-108652

α,β-Methylene ATP trisodium	P2X Receptor	Inflammation/Immunology
α,β-Methylene ATP trisodium, a phosphonic analog of ATP, is a P2X3 and P2X7 receptor ligand. α,β-Methylene ATP trisodium is a highly selective agonist for P2X1 and P2X3, with practically no activity at P2X2,4-7.

HY-134440

α,β-Methylene-ATP dilithium	P2X Receptor	Inflammation/Immunology
α,β-Methylene ATP dilithium, a phosphonic analog of ATP, is a P2X3 and P2X7 receptor ligand. α,β-Methylene ATP dilithium is a highly selective agonist for *P2X1* and P2X3, with practically no activity at P2X2,4-7.

HY-W054064

6-Chloro-7-deazapurine-β-D-riboside
Fungal Infection

Chloro-7-deazapurine-β-D-riboside is a nucleoside derivative and has antifungal activity.
HY-N8054

1-Hydroxypinoresinol 1-O-β-D-glucoside
Reactive Oxygen Species Others

1-Hydroxypinoresinol 1-O-β-D-glucoside (Compound 4) is an antioxidative compound.

HY-N0197

Baicalin Baicalein 7-O-β-D-glucuronide	NF-κB Autophagy HIV	Inflammation/Immunology Cancer
Baicalin, as a flavonoid glycoside, is an allosteric carnitine palmityl transferase 1 (CPT1) activator. Baicalin reduces the expression of *NF-κB*.

HY-N0377

Liquiritigenin 4',7-Dihydroxyflavanone	Estrogen Receptor/ERR	Cancer Inflammation/Immunology Neurological Disease
Liquiritigenin, a flavanone isolated from Glycyrrhiza uralensis, is a highly selective estrogen receptor β (ERβ) agonist with an EC₅₀ of 36.5 nM for activation of the ERE tk-Luc.

HY-75342

Methyl vanillate	Wnt Reactive Oxygen Species Endogenous Metabolite	Inflammation/Immunology Cancer
Methyl vanillate, one of the ingredients in Oryza sativa Linn., is a *Wnt/β-catenin* pathway activator. A benzoate ester that is the methyl ester of vanillic acid. It has a role as an antioxidant and a plant metabolite.

HY-107586

Demethylasterriquinone B1 DAQ B1; L-783281; Dimethylasterriquinone	Insulin Receptor Akt	Endocrinology
Demethylasterriquinone B1 is a selective insulin receptor activator. Demethylasterriquinone B1 stimulates tyrosine phosphorylation of the IR β subunit, and the activation of PIK3 and *AKT*.

HY-N2601

Bayogenin 3-O-β-D-glucopyranoside	Others	Inflammation/Immunology
Bayogenin 3-O-β-D-glucopyranoside, a triterpenoid saponin isolated from Polygala japonica, possesses anti-inflammatory activities.

HY-N10439

3β-Acetoxy-hop-22(29)-ene	Glucosidase	Inflammation/Immunology
3β-Acetoxy-hop-22(29)-ene (compound 1) is a potent anti-inflammatory agent. 3β-Acetoxy-hop-22(29)-ene shows high inhibitory activity of yeast α-glucosidase, with an IC₅₀ of 5.74 μM. 3β-Acetoxy-hop-22(29)-ene inhibits MPO (myeloperoxidase) activity in a dose-dependent manner in mouse ear edema model induced by 12-O-tetradecanoylphorbol acetate (TPA), with an IC₅₀ of 0.23 μmol/ear.

HY-109564

5α-Pregnane-3β,6α-diol-20-one	Others	Cancer
5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite of progesterone, and it can be produced in starved androgen-responsive prostate cancer cells.

HY-B0406

Bethanechol Carbamyl-β-methylcholine	mAChR	Neurological Disease
Bethanechol (Carbamyl-β-methylcholine), a parasympathomimetic agent, is a mAChR agonist that exerts its effects via directly stimulating the mAChR (M1, M2, M3, M4, and M5) of the parasympathetic nervous system.

HY-B0406A

Bethanechol chloride Carbamyl-β-methylcholine chloride	mAChR	Neurological Disease
Bethanechol chloride (Carbamyl-β-methylcholine chloride), a parasympathomimetic agent, is a mAChR agonist that exerts its effects via directly stimulating the mAChR (M1, M2, M3, M4, and M5) of the parasympathetic nervous system.

HY-N0713

Diosmetin-7-O-β-D-glucopyranoside	Others	Others
Diosmetin-7-O-β-D-glucopyranoside is a natural product isolated from the flowers of Chrysanthemum morifolium, with antioxidant activity.

HY-N8205

Hispidulin 4'-O-β-D-glucopyranoside	SARS-CoV	Infection Inflammation/Immunology
Hispidulin 4'-O-β-D-glucopyranosid, a natural compound, may serve as a potential COVID-19 main protease inhibitor.

HY-N2213

Matairesinol 4′-O-β-D-glucopyranoside
Others Cancer

Matairesinol 4′-O-β-D-glucopyranoside displays cytotoxic activity against HeLa cell line with an IC₅₀ of 47.1 μM.

HY-N2182

Episyringaresinol 4'-O-β-D-glncopyranoside	Others	Inflammation/Immunology
Episyringaresinol 4'-O-β-D-glncopyranoside (compound 22), isolated from Alhagi sparsifolia Shap, is a natural potential neuroinflammatory inhibitor.

HY-N0230S2

β-Alanine-d4 2-Carboxyethylamine-d4; 3-Aminopropanoic acid-d4	Endogenous Metabolite	Metabolic Disease
β-Alanine-d4 (2-Carboxyethylamine-d4) is the deuterium labeled β-Alanine. β-Alanine is a non-essential amino acid that is shown to be metabolized into carnosine, which functions as an intracellular buffer.

HY-N9522

β-D-glucopyranosyl-[α-L-rhamnopyranosyl-(1→3)-βD-glucuronopyranosyl-(1→3)]-3β-hydroxyolean-12-ene28-oate	Others	Others
β-D-glucopyranosyl-[α-L-rhamnopyranosyl-(1→3)-βD-glucuronopyranosyl-(1→3)]-3β-hydroxyolean-12-ene28-oate, as a saponin, has a glucuronic acid attached to carbon C-3 and is isolated from S. simplex.

HY-P1866A

β-Endorphin, equine TFA	Opioid Receptor	Neurological Disease
β-Endorphin, equine (TFA) is an endogenous opioid peptide, which binds at high affinity to both μ/δ opioid receptors. Analgesic properties.

HY-N5039

1,2-O-Dilinoleoyl-3-O-Beta-D-Galactopyranosylracglycerol 1,2-O-Dilinoleoyl-3-O-β-D-galactopyranosylracglycerol	Others	Others
1,2-O-Dilinoleoyl-3-O-Beta-D-Galactopyranosylracglycerol is isolated from the flower of Magnolia denudate.

HY-N8161

Kaempferol-3,7-di-O-β-glucoside Kaempferol 3,7-diglucoside	Glucosidase Cholinesterase (ChE)	Neurological Disease
Kaempferol-3,7-di-O-β-glucoside (Kaempferol 3,7-diglucoside), a flavonol, possesses enzyme inhibition property towards α-amylase, α-glucosidase and Acetylcholinesterase. Kaempferol-3,7-di-O-β-glucoside protects differentiating neuronal cells, SH-SY5Y from Amyloid β peptide-induced injury. Kaempferol-3,7-di-O-β-glucoside has the potential for Alzheimer's research.

HY-115537

NAE-IN-M22	Apoptosis	Cancer
NAE-IN-M22 is a potent, selective and reversible inhibitor of *NEDD8 activating* enzyme (NAE)*, with potency in micromolar range. NAE-IN-M22 inhibits multiple cancer cell lines and induces apoptosis in A549 cells. NAE-IN-M22 also can inhibit tumor growth in vivo.*

HY-N10390

3β-Hydroxylanosta-8,24-dien-21-al	Others	Cancer
3β-Hydroxylanosta-8,24-dien-21-al is a lanostane-type triterpene. 3β-Hydroxylanosta-8,24-dien-21-al can inhibit the tumor promotion, reducing the percentage of mice bearing papillomas.

HY-101923B

LYN-1604 dihydrochloride	ULK Autophagy Apoptosis	Cancer
LYN-1604 dihydrochloride is a potent UNC-51-like kinase 1 (ULK1) activator (EC₅₀=18.94 nM) for the research of triple negative breast cancer (TNBC).

HY-101923A

LYN-1604 hydrochloride	ULK Autophagy Apoptosis	Cancer
LYN-1604 hydrochloride is a potent UNC-51-like kinase 1 (ULK1) activator (EC₅₀=18.94 nM) for the research of triple negative breast cancer (TNBC).

HY-101923

LYN-1604
ULK Autophagy Apoptosis Cancer

LYN-1604 is a potent UNC-51-like kinase 1 (ULK1) activator (EC₅₀=18.94 nM) for the research of triple negative breast cancer (TNBC).

HY-112331

SJ000291942	TGF-β Receptor	Cancer
SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway. BMPs are members of the transforming growth factor beta (TGFβ) family of secreted signaling molecules.

HY-N8209

(+)-Medioresinol Di-O-β-D-glucopyranoside	Phosphodiesterase (PDE)	Inflammation/Immunology
(+)-Medioresinol Di-O-β-D-glucopyranoside is a lignan glucoside with strong inhibitory activity of 3', 5'-cyclic monophosphate (cyclic AMP) phosphodiesterase.

HY-N2094

*Genipin 1-β-D-gentiobioside* Genipin 1-gentiobioside; Genipin 1-β-gentiobioside; Genipin gentiobioside	Others	Inflammation/Immunology
Genipin 1-β-D-gentiobioside (Genipin 1-gentiobioside) is one of the most abundant and bioactive iridoid glycosides in Gardenia jasminoides Ellis, which possesses hepatoprotective, anti-inflammatory, antioxidant, and antithrombotic activities.

HY-113492

5(S)15(S)-DiHETE	Interleukin Related	Inflammation/Immunology Cardiovascular Disease
5(S)15(S)-DiHETE is an “activated” intermediate, inhibits platelet aggregation with an IC₅₀ of 1.3 μM. 5(S)15(S)-DiHETE enhances the rate of either LXA4 or LXB4 biosynthesis.

HY-B0406AS

Bethanechol-d6 chloride Carbamyl-β-methylcholine-d6 chloride	mAChR	Neurological Disease
Bethanechol-d6 (Carbamyl-β-methylcholine-d6) chloride is the deuterium labeled Bethanechol chloride. Bethanechol chloride (Carbamyl-β-methylcholine chloride), a parasympathomimetic agent, is a mAChR agonist that exerts its effects via directly stimulating the mAChR (M1, M2, M3, M4, and M5) of the parasympathetic nervous system.

HY-N3991

14β-Benzoyloxy-2-deacetylbaccatin VI	Others	Others
14β-Benzoyloxy-2-deacetylbaccatin VI is a xetane-ring-containing taxoid compound isolated from the leaves and stems of Taxus chinensis.

HY-N0230S1

β-Alanine-15N 2-Carboxyethylamine-15N; 3-Aminopropanoic acid-15N	Endogenous Metabolite	Metabolic Disease
β-Alanine-15N (2-Carboxyethylamine-15N) is the 15N-labeled β-Alanine. β-Alanine is a non-essential amino acid that is shown to be metabolized into carnosine, which functions as an intracellular buffer.

HY-115768

Compound 48/80 Poly-p-methoxyphenethylmethylamine	Others	Cancer Neurological Disease
Compound 48/80 (Poly-p-methoxyphenethylmethylamine) is widely used in animal and tissue models as a "selective" mast cell activator. Compound 48/80 acts at the mast cell membrane to stimulate trimeric G-proteins and induces degranulation via phospholipase C and D pathways.

HY-111974

β-D-Glucopyranosyl abscisate ABA-GE; (S)-cis,trans-Abscisic acid glucosyl ester	Others	Endocrinology
β-D-Glucopyranosyl abscisate (ABA-GE) is a hydrolyzable abscisic acid (ABA) conjugate that accumulates in the vacuole and presumably also in the endoplasmic reticulum. The deconjugation of β-D-Glucopyranosyl abscisate allows the rapid formation of free ABA in response to abiotic stress conditions such as dehydration and salt stress. β-D-Glucopyranosyl abscisate contributes to the maintenance of ABA homeostasis.

HY-N3517

Oxyresveratrol 3'-O-β-D-glucopyranoside	Tyrosinase	Metabolic Disease
Oxyresveratrol 3'-O-β-D-glucopyranoside is a phenolic compound isolated from Morus nigra root and is an effective tyrosinase inhibitor with an IC₅₀ of 1.64 μM.

HY-N3516

Oxyresveratrol 2-O-β-D-glucopyranoside	Tyrosinase	Metabolic Disease
Oxyresveratrol 2-O-β-D-glucopyranoside is a phenolic compound isolated from Morus nigra root and is an effective tyrosinase inhibitor with an IC₅₀ of 29.75 μM.

HY-N7604

Isorubrofusarin-6-O-β-gentiobioside Isorubrofusarin gentiobioside	Others	Others
Isorubrofusarin-6-O-β-gentiobioside (Isorubrofusarin gentiobioside) is a naphthopyrone glycoside isolated from Cassia obtusifolia Linn seeds.

HY-N6605

Kaempferol 3-O-β-D-galactopyranoside Trifolin	Others	Cancer Cardiovascular Disease
Kaempferol 3-O-β-D-galactopyranoside (Trifolin) is a derivative of flavonoid, which is isolated from the aerial part of Consolida oliveriana.

HY-P1504A

β-Melanocyte Stimulating Hormone (MSH), human TFA beta-MSH (1-22) (human) TFA	Melanocortin Receptor	Metabolic Disease Neurological Disease Endocrinology
β-Melanocyte Stimulating Hormone (MSH), human TFA, a 22-residue peptide, acts as an endogenous melanocortin-4 receptor (MC4-R) agonist.

HY-111447

VAS 3947	NADPH Oxidase Apoptosis	Cancer Cardiovascular Disease
VAS 3947, a specific NADPH oxidase (NOX) inhibitor, exerts a potent antiplatelet effect. VAS3947 induces apoptosis independently of anti-NOX activity, via UPR activation, mainly due to aggregation and misfolding of proteins.

HY-P1388A

β-Amyloid (1-42), (rat/mouse) (TFA) Amyloid β-peptide (1-42) (rat/mouse) TFA	Amyloid-β	Neurological Disease
β-Amyloid (1-42), (rat/mouse) TFA is a 42-aa peptide, shows cytotoxic effect on acute hippocampal slices, and used in the research of Alzheimer's disease.

HY-10133

β-Secretase Inhibitor IV	Beta-secretase	Neurological Disease
β-Secretase Inhibitor IV is a potent, cell-active *BACE-1* inhibitor with IC₅₀s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively.

HY-151375

CDK9/10/GSK3β-IN-1	Others	Cancer
CDK9/10/GSK3β-IN-1 (compound 13c) is a kinase inhibitor (Flavopiridol (HY-10005) analogue) that effectively inhibits *HsGSK3β* (IC₅₀=59 nM), HsCDK9/CyclinT (IC₅₀=64 nM), *HsCDK5/p25* (IC₅₀=1.093 µM) and HsCDK2/CyclinA (IC₅₀=1.725 µM). CDK9/10/GSK3β-IN-1 has anti-cancer cellular activity comparable to or higher than that of Flavopiridol. CDK9/10/GSK3β-IN-1 shows high anti-proliferative activity in vitro against up to seven cancer cell lines.

HY-B0672

Estradiol valerianate β-Estradiol 17-valerate	Estrogen Receptor/ERR	Endocrinology Cancer
Estradiol valerianate (β-estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy drugs.

HY-N7162

3-O-Acetyl-11-hydroxy-beta-boswellic acid
Lipoxygenase Others

3-O-Acetyl-11-hydroxy-beta-boswellic acid is a potent 5-lipoxygenase (5-LO) inhibitor.
HY-136614

H-Val-βNA
L-Valine β-naphthylamide
Others Others

H-Val-βNA (L-Valine β-naphthylamide) can be used as an aminopeptidase and a Valine arylamidase substrate.

HY-W012875

3-Nitropropanoic acid β-Nitropropionic acid; Bovinocidin	Bacterial Apoptosis	Infection Metabolic Disease
3-Nitropropanoic acid (β-Nitropropionic acid) is an irreversible inhibitor of succinate dehydrogenase. 3-Nitropropanoic acid exhibits potent antimycobacterial activity with a MIC value of 3.3 μM.

HY-N0627

Kaempferol-7-O-β-D-glucopyranoside	Others	Inflammation/Immunology
Kaempferol-7-O-β-D-glucopyranoside is a flavonoid isolated from Malus pumila Mill. flowers, has antioxidative, anti-inflammatory and procoagulant activitives.

HY-135588

Raloxifene 6,4'-Bis-β-D-glucuronide	Drug Metabolite	Metabolic Disease
Raloxifene 6,4'-Bis-β-D-glucuronide (compound IV) is a metabolite of Raloxifene. Raloxifene is a selective estrogen receptor antagonist for the prevention of osteoporosis.

HY-N4180

*Pennogenin 3-O-beta-chacotrioside*	Autophagy	Cancer
Pennogenin 3-O-beta-chacotrioside is an active component isolated from Paris polyphylla, modulates autophagy via increasing the expressions of autophagy-related proteins LC3 and Beclin-1. Anti-colorectal cancer activity.

HY-B1209

Etofylline 7-(β-Hydroxyethyl)theophylline	Others	Cardiovascular Disease
Etofylline (7-(β-Hydroxyethyl)theophylline) is a N-7-substituted derivative of Theophylline. Etofylline is a bronchodilator which can be used for the research of asthma. Etofylline is also an anticholesteremic and reduces total cholesterol level in the blood.

HY-113013

Hydroxypyruvic acid β-Hydroxypyruvic acid; 3-Hydroxypyruvic acid	Endogenous Metabolite	Metabolic Disease
Hydroxypyruvic acid (β-Hydroxypyruvic acid) is an intermediate in the metabolism of glycine, serine and threonine. Hydroxypyruvic acid is a substrate for serine-pyruvate aminotransferase and glyoxylate reductase/hydroxypyruvate reductase. Hydroxypyruvic acid is involved in the metabolic disorder which is the dimethylglycine dehydrogenase deficiency pathway.

HY-N10450

Kumujian A 1-Ethoxycarbonyl-β-carboline	Reactive Oxygen Species	Inflammation/Immunology
Kumujian A (1-Ethoxycarbonyl-β-carboline), an anti-inflammatory agent, inhibits both superoxide anion generation (IC₅₀ = 4.87 μg/mL) and elastase release (IC₅₀ = 6.29 μg/mL).

HY-135955

Levothyroxine acyl glucuronide Thyroxine acyl-β-D-glucuronide	Endogenous Metabolite	Metabolic Disease
Levothyroxine acyl glucuronide (Thyroxine Acyl-β-D-glucuronide), an endogenous metabolite, is the acyl glucuronide formation of thyroxine (T4).

HY-W251393

S-(2-Carboxypropyl)-L-cysteine β-Isobuteine	Endogenous Metabolite	Metabolic Disease
S-(2-Carboxypropyl)-L-cysteine (β-Isobuteine) is a urine metabolite, a metabolic marker of leigh-like syndrome.

HY-W007648

Methyl 3-aminopropanoate hydrochloride β-Alanine methyl ester hydrochloride	Others	Others
Methyl 3-aminopropanoate hydrochloride is prepared by esterification of Β-Alanine (I). Methyl 3-aminopropanoate hydrochloride can be used in the synthesis of bidentate pyridine-acid ligand.

HY-N7422

Kauran-16,17-diol ent-Kauran-16β,17-diol	Apoptosis	Cancer Inflammation/Immunology
Kauran-16,17-diol (ent-Kauran-16β,17-diol), a natural diterpene, posseses anti-tumor and inducing-apoptosis activity, with a IC₅₀ of 17 μM on inhibiting NO production in LPS-stimulated RAW 264.7 macrophages.

HY-115365

(3β,20E)-24-Norchola-5,20(22)-diene-3,23-diol
Others Others

(3β,20E)-24-Norchola-5,20(22)-diene-3,23-diol is a steroid-based allylic alcohol.

HY-N3811

ent-11β-Hydroxyatis-16-ene-3,14-dione	RSV	Infection
ent-11β-Hydroxyatis-16-ene-3,14-dione (compound 11) is a diterpenoid from the fresh roots of Euphorbia jolkinii. ent-11β-Hydroxyatis-16-ene-3,14-dione has anti-RSV activity.

HY-137331

FAPI-46	Others	Cancer
FAPI-46 is a quinoline-based *fibroblast activation* protein (FAP)*-targeted radiotracer. FAPI-46 has higher tumor uptake and prolonged tumor accumulation. FAPI-46 can be used for tumor imaging of a multitude of different cancers.*

HY-N7681

Taxifolin 7-O-β-D-glucoside Taxifolin 7-O-glucoside	Others	Others
Taxifolin 7-O-β-D-glucoside (Taxifolin 7-O-glucoside) is one of the main metabolites at the seed germination stage in Scutellaria baicalensis. Taxifolin 7-O-β-D-glucoside, a flavonoid, mainly exists in the episperm and participates in defending against pathogens and UV-damage.

HY-N7024

Quercetin 3-O-(6''-galloyl)-β-D-galactopyranoside
Others Metabolic Disease

Quercetin 3-O-(6''-galloyl)-β-D-galactopyranoside is from the fresh leaves of Psidium Guajava L..

HY-129993

*Gemfibrozil 1-O-β-glucuronide*	PPAR Cytochrome P450 Drug Metabolite	Metabolic Disease Cardiovascular Disease
Gemfibrozil 1-O-β-Glucuronide, a metabolite of Gemfibrozil (CI-719; HY-B0258), is a potent and competitive P450 (CYP) isoform CYP2C8 inhibitor with an IC₅₀ of 4.07 μM.

HY-N5131

3β-Methoxy-2,3-dihydrowithaferin A
Quresimin A
Others Others

3β-Methoxy-2,3-dihydrowithaferin A is one of withanolides found in Withania somnifera.

HY-N7035

*Wogonin 7-O-beta-D-glucuronide methyl ester* Wogonoside methyl ester	Others	Metabolic Disease
Wogonin 7-O-beta-D-glucuronide methyl ester is a natural compound isolated from Huanglian Jiedutang.

HY-N10128

(8′α,9′β-Dihydroxy)-3-farnesylindole
Bacterial Infection

(8'α,9'β-Dihydroxy)-3-farnesylindole shows strong inhibitory activity (EC₅₀ 9.8 μM) against B. subtilis.

HY-12545

Brevetoxin-3 PbTx-3	Sodium Channel	Inflammation/Immunology
Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na⁺ channel activator and has multiple active centers (A-ring lactone, C-42 of R side chain). Brevetoxin-3 (PbTx-3) has a high affinity to site 5 of the voltage-sensitive Na⁺ channels, inhibits the inactivation of Na⁺ channels and prolongs the mean open time of these channels. Brevetoxin-3 (PbTx-3) repeated exposures can lead to prolonged airway hyperresponsiveness (AHR) and lung inflammation.

HY-107238

(3β,24R)-3-(Acetyloxy)eupha-7,25-dien-24-ol	Others	Others
(3β,24R)-3-(Acetyloxy)eupha-7,25-dien-24-ol is an euphane triterpene compound isolated from the barks of Broussonetia papyrifera.

HY-N7003

28-Demethyl-β-amyrone 28-Norolean-12-en-3-one	Bacterial	Infection
28-Demethyl-β-amyrone (28-Norolean-12-en-3-one) is one of the main triterpenes from Pistacia lentiscus var. Chia. 28-Demethyl-β-amyrone is an antitoxin and can effectively for the toxic effects of Staphylococcal enterotoxins (SEs).

HY-139654

α/β-Hydrolase-IN-1	Others	Infection
α/β-Hydrolase-IN-1 exhibits the best-in-class MICs of 50 μM (25 μg/mL) and 16 μM (8.4 μg/mL) against M. smegmatis and M. tuberculosis H37Ra, respectively.

HY-N2394

*Emodin-1-O-β-D-glucopyranoside*	Others	Inflammation/Immunology
Emodin-1-O-β-D-glucopyranoside, isolated from medicinal plant Polygonum cuspidatum Sieb. & Zucc, is a potent and noncompetitive bacterial neuraminidase (BNA) inhibitor with an IC₅₀ of 0.85 μM.

HY-10595

RO-28-1675	Glucokinase	Metabolic Disease
RO-28-1675 is a potent allosteric glucokinase (GK) activator with an EC₅₀ of 54 nM. RO-28-1675 can be used for the research of type 2 diabetes.

HY-N1718

2α,3β,24-Trihydroxyurs-12-en-28-oic acid 2,24-Dihydroxyursolic acid	Others	Others
2α,3β,24-Trihydroxyurs-12-en-28-oic acid is a natural product that can be isolated from Salvia palaestina.

HY-11012

TDZD-8 GSK-3β Inhibitor I; NP 01139	GSK-3	Cancer
TDZD-8 is an inhibitor of *GSK-3β, with an IC₅₀* of 2 μM; TDZD-8 shows less potent activities against Cdk-1/cyclin B, CK-II, PKA, and PKC, with all IC₅₀s of >100 μM.

HY-141133

Propargyl-PEG4-tetra-Ac-beta-D-glucose
PROTAC Linkers Cancer

Propargyl-PEG4-tetra-Ac-beta-D-glucose is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-N4179

Aurantio-obtusin β-D-glucoside Glucoaurantio-obtusin	Others	Metabolic Disease
Aurantio-obtusin β-D-glucoside (Glucoaurantio-obtusin), isolated from Cassiae Semen (seeds of Cassia tora), is a glucoside of aurantio-obtusin.

HY-141135

Propargyl-PEG4-tetra-Ac-beta-D-galactose
PROTAC Linkers Cancer

Propargyl-PEG4-tetra-Ac-beta-D-galactose is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-141127

Azido-PEG4-tetra-Ac-beta-D-glucose
PROTAC Linkers Cancer

Azido-PEG4-tetra-Ac-beta-D-glucose is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-N0815

Resibufogenin Bufogenin; Recibufogenin	Others	Cancer
Resibufogenin, a component of huachansu, has been shown to exhibit the anti-proliferative effect against cancer cells, and this may be attributed to the degradation of cyclin D1 caused by the activation of GSK-3β.

HY-13555

β-Lapachone ARQ-501; NSC-26326	Topoisomerase Autophagy Apoptosis	Cancer
β-Lapachone (ARQ-501;NSC-26326) is a naturally occurring O-naphthoquinone, acts as a topoisomerase I inhibitor, and induces apoptosis by inhibiting cell cycle progression.

HY-N0192

Arbutin β-Arbutin	Tyrosinase Endogenous Metabolite	Cancer
Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase, with K_i^app values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents. Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties.

HY-122009

Indican
Indoxyl-β-D-glucoside
Others