Search Result
Results for "
Active Integrinalpha 2b beta 3 Inhibitors
" in MedChemExpress (MCE) Product Catalog:
9633
Inhibitors & Agonists
571
Biochemical Assay Reagents
504
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-P1108A
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CFTR
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Others
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Astressin 2B TFA is a potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist, with the IC50 values of 1.3 nM and > 500 nM for CRF2 and CRF1, respectively. Astressin 2B TFA antagonizes CRF2-mediated inhibition of gastric emptying [2] [3].
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- HY-145894
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Sodium Channel
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Others
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NaPi2b-IN-2 (compound 5) is a potent inhibitor of sodium-dependent transport protein 2b (SLC34A2, NaPi2b), with an IC50 of 38 nM for human NaPi2b. NaPi2b-IN-2 can be used for the research of hyperphosphatemia .
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- HY-P1108
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CFTR
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Others
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Astressin 2B is a potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist, with the IC50 values of 1.3 nM and > 500 nM for CRF2 and CRF1, respectively. Astressin 2B antagonizes CRF2-mediated inhibition of gastric emptying [2] [3].
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- HY-116834
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Ciba Blue 2b
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Biochemical Assay Reagents
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Others
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Vat Blue 4B (Ciba Blue 2B) is a biochemical reagent. Vat Blue 4B is a kind of biological materials or organic compounds that are widely used in life science research .
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- HY-111206
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- HY-P1114
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GSK-3
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Neurological Disease
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2B-(SP) is a eIF2B-based substrate for glycogen synthase kinase-3 (GSK-3). 2B-(SP) is readily phosphorylated by both the α and β isoforms of GSK-3 .
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- HY-P1114A
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GSK-3
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Cancer
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2B-(SP) TFA is a eIF2B-based substrate for glycogen synthase kinase-3 (GSK-3). 2B-(SP) TFA is readily phosphorylated by both the α and β isoforms of GSK-3 .
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- HY-P99348
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Ropeginterferon alfa-2b-njft; PEG-proline-interferon alpha-2b
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Apoptosis
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Cancer
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Ropeginterferon alfa-2b (Ropeginterferon alfa-2b-njft) is a monopegylated IFN-α that can be used for the research of myeloproliferative neoplasms .
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- HY-145897
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- HY-P99735
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IFNAR
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Infection
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Mipeginterferon alfa-2b is an interferon alpha-2b (IFNA2b) analogue, with an average number of 5 substituted among 11 amino groups (one N-terminal and 10 lysine N6). Mipeginterferon alfa-2b has the relative molecular mass of 40 kDa .
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- HY-P5695
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Bacterial
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Infection
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GP-2B is an antimicrobial peptide. GP-2B shows antibacterial activity against Gram-positive strain (MIC: 8-128 μg/mL for S. aureus and Enterococcus faecalis) .
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- HY-P5189A
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Endogenous Metabolite
Cholinesterase (ChE)
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Others
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His-D-beta-Nal-Ala-Trp-D-Phe-Lys-NH2 TFA, is a growth hormone releasing peptide, as well as a metabolite of GHRP-1. GHRP-1, or Ala-His-D-beta Nal-Ala-Trp-D-Phe-Lys-NH2, has the effect of promoting the release of growth hormone (GH). GHRP-1 increases GH release and increases [Ca2+]i levels in static monolayer cells of rat pituitary gland, but does not affect cAMP levels .
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- HY-142957
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Sodium Channel
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Others
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NaPi2b-IN-1 is a potent and orally active inhibitor of sodium-dependent phosphate transport protein 2b (NaPi2b) with an IC50 of 64 nM. NaPi2b is primarily expressed in the small intestine, lungs, and testes and plays an important role in phosphate homeostasis. NaPi2b-IN-1 has the potential for the research of hyperphosphatemia .
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- HY-146429
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Sodium Channel
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Metabolic Disease
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NaPi2b-IN-3 (compound 5) is a potent sodium-dependent transport protein 2b (SLC34A2, NaPi2b) inhibitor with IC50s of 71 nM and 28 nM for human NaPi2b and rat NaPi2b, respectively. NaPi2b-IN-3 can be used for researching hyperphosphatemia .
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- HY-147719
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COX
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Inflammation/Immunology
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COX-2-IN-16 (compound 2b) is a potent, selective and orally active COX-2 inhibitor with an IC50 of 102 µM. COX-2-IN-16 inhibits the NO production. COX-2-IN-16 shows anti-inflammatory activity .
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- HY-131048
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Bacterial
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Infection
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Antimicrobial agent-33 (Compound 2b) is an antimicrobial agent, with MIC values of 2-64 μg/mL. Antimicrobial agent-33 is an active compound against Staph. Aureus .
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- HY-12294
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NVP-AAM077
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Caspase
Apoptosis
iGluR
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Neurological Disease
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PEAQX (NVP-AAM077) is an orally active and selective NMDA antagonist, with IC50 values of 270 nM and 29.6 μM for hNMDAR 1A/2A and hNMDAR 1A/2B, respectively. PEAQX can promote the activation of caspase-3 and induce cell apoptosis in cortical striatal slice cultures [2].
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- HY-151145
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Glycosidase
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Metabolic Disease
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α-Glucosidase-IN-21 (Compound 2B) is a potent, orally active α-glucosidase inhibitor with an IC50 of 2.62 μM. α-Glucosidase-IN-21 shows anti-diabetic activity .
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- HY-B2006
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Phosphatase
Bacterial
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Infection
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Fenvalerate is a potent protein phosphatase 2B (calcineurin) inhibitor with an IC50 of 2-4 nM for PP2B-Aα. Fenvalerate is a pyrethroid ester insecticide and acaricide .
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- HY-101337
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- HY-101337A
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RS 21361
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Adrenergic Receptor
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Metabolic Disease
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Imiloxan hydrochloride is a potent and selective alpha 2B-adrenoceptor antagonist. Imiloxan hydrochloride has the potential for acute kidney injury research [2].
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- HY-160777
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Galeterone 3β-imidazole
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Molecular Glues
Androgen Receptor
MNK
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Cancer
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VNPP433-3β is a molecular glue degrader, which degrades androgen receptor (AR) and its splice variants (AR-Vs) and MAP kinase-interacting serine/threonine protein kinase Mnk1/2. VNPP433-3β inhibits proliferation of cancer cell LNCaP, C4-2B and CWR22Rv1 with GI50 of 0.2, 0.3 and 0.31 μM. VNPP433-3β exhibits good pharmacokinetic characters in CD-1 mouse and inhibits tumor growth in the CWR22Rv1 xenograft mouse model .
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- HY-N12250
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Others
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Cancer
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7-Deoxynarciclasine (compound 2b) can be isolated from Hymenocallis littoralis. 7-Deoxynarciclasine inhibits the cancer cell growth .
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- HY-12294A
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NVP-AAM077 tetrasodium hydrate
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Apoptosis
Caspase
iGluR
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Neurological Disease
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PEAQX tetrasodium hydrate (NVP-AAM077 tetrasodium hydrate) is a tetrasodium hydrate of PEAQX (HY-12294). PEAQX tetrasodium hydrate is an orally active and selective NMDA antagonist, with IC50 values of 270 nM and 29.6 μM for hNMDAR 1A/2A and hNMDAR 1A/2B, respectively. PEAQX tetrasodium hydrate can promote the activation of caspase-3 and induce cell apoptosis in cortical striatal slice cultures [2].
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- HY-169229
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5-HT Receptor
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Cancer
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GM-60186 is a 5-HT receptor 2B (HTR2B) inhibitor with an IC50 of 257 nM. GM-60186 significantly inhibits colorectal cancer proliferation and migration .
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- HY-162852
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G-quadruplex
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Cancer
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OAF89 is a small molecule that interacts with G-Quadruplexes (G4s) and dsDNA with an IC50 of 1.07 μM in normal lung epithelial cells BEAS-2B .
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- HY-P99666
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IFNAR
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Infection
Cancer
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Albinterferon alfa-2b is a type I interferon that activates novel genes and exerts potent antiviral and antiproliferative activity on target cells. Signaling by Albinterferon alfa-2b requires receptor-dependent activation of Stat1 and Stat2 to form a heterodimeric STAT that binds to the DNA-binding protein IRF-9 (p48) and forms ISGF-3 (IFN-stimulated gene factor 3). The driver genes are then further activated by ISGF-3 to achieve antiviral function .
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- HY-106441A
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MK-0657; CERC-301
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iGluR
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Neurological Disease
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Rislenemdaz (CERC-301) is an orally bioavailable and selective N-methyl-D-aspartate (NMDA) receptor subunit 2B (GluN2B) antagonist with Ki and IC 50 of 8.1 nM and 3.6 nM, respectively.
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- HY-142772
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Epigenetic Reader Domain
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Cancer
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Y08284 is a potent, selective, oral active CBP bromodomain inhibitor with an IC50 of 4.21 nM. Y08284 suppresses the proliferation of prostate cancer cell lines LNCaP, C4-2B, and 22Rv1. Antitumor activity .
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- HY-103521
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GABA Receptor
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Neurological Disease
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Anxiolytic/nonsedative agent-1 (compound 2b) is a potent and selective GABAA agonist. Anxiolytic/nonsedative agent-1 shows appreciable affinity for the BzR in bovine brain membranes with Kis of 14, 121, 239 nM for α1β2γ2, α2β2γ2, α5β3γ2, respectively. Anxiolytic/nonsedative agent-1 shows α2 selective efficacy in vitro and anxioselective effects in vivo .
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- HY-16729
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YKP10811
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5-HT Receptor
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Metabolic Disease
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Relenopride is a agonist of novel potent 5-HT4 receptor partial with weak binding to 5-HT 2B receptors (Ki = 31 nM) .
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- HY-145472
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Biochemical Assay Reagents
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Cancer
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Sphingosine (d18:1) alkyne (compound 2b) is an alkyne-labeled Sphingosine (d18:1) that can be used in click chemistry reactions .
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- HY-W008038
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iGluR
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Others
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NMDAR antagonist 3 (Compound 2) is an antagonist of the NMDA receptor. NMDAR antagonist 3 has a certain but weak inhibitory activity against the NR1A/2B subtype of the NMDA receptor .
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- HY-W740628
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Drug Metabolite
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Neurological Disease
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Nicorandil pyridine oxide is a metabolite of the sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel Kir6.2 (SUR2B/Kir6.2) activator and nitric oxide donor Nicorandil.
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- HY-B2006S
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Phosphatase
Bacterial
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Infection
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Fenvalerate-d5 is the deuterium labeled Fenvalerate. Fenvalerate is a potent protein phosphatase 2B (calcineurin) inhibitor with an IC50 of 2-4 nM for PP2B-Aα. Fenvalerate is a pyrethroid ester insecticide and acaricide[1].
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- HY-114732
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Adrenergic Receptor
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Others
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Procaterol is an oral selective β2 adrenergic receptor agonist. Procaterol inhibits eosinophil migration and the release of eosinophil chemotactic factor from BEAS-2B cells through a cyclic AMP-dependent mechanism. Procaterol has a large dose difference existing between the bronchodilator effect and the anabolic effect in rat, can be used for asthma research in athletes .
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- HY-107707
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iGluR
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Neurological Disease
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TCS 46b (Compound 46b) is a potent, selective and orally active NMDA NR1A/2B receptor antagonist with an IC50 of 5.3 nM . TCS 46b is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-B2006R
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Phosphatase
Bacterial
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Infection
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Fenvalerate (Standard) is the analytical standard of Fenvalerate. This product is intended for research and analytical applications. Fenvalerate is a potent protein phosphatase 2B (calcineurin) inhibitor with an IC50 of 2-4 nM for PP2B-Aα. Fenvalerate is a pyrethroid ester insecticide and acaricide .
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- HY-15472A
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5-HT Receptor
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Cardiovascular Disease
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PRX-08066 is a selective 5-hydroxytryptamine receptor 2B (5-HT2BR, IC50= 3.4 nM) antagonist that causes selective vasodilation of pulmonary arteries.
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- HY-15472
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5-HT Receptor
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Cardiovascular Disease
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PRX-08066 is a selective 5-hydroxytryptamine receptor 2B (5-HT2BR, IC50= 3.4 nM) antagonist that causes selective vasodilation of pulmonary arteries.
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- HY-161691
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Filovirus
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Infection
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EBOV-IN-9 (compound 2b) is Diphyllin derivative that blocks Ebola viral entry with an EC50 of 40 nM. EBOV-IN-9 against EBOV-infected monocyte-derived macrophages with an EC50 of 107 nM .
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- HY-122120
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AJ‐9677
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Adrenergic Receptor
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Metabolic Disease
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Rafabegron (AJ-9677) is a specific beta3-adrenoceptor agonist. Rafabegron can reduce blood glucose, insulin, FFA, and triglyceride levels in diabetic and obese mouse models .
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- HY-160210
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Adrenergic Receptor
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Cardiovascular Disease
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BAY-6096 is a potent, selective, and highly water-soluble adrenergic receptor α2B antagonist with an IC50 of 14 nM. BAY-6096 can effectively reduceα 2B receptor agonist-induced rat vascular contraction .
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- HY-103154
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5-HT Receptor
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Neurological Disease
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SB228357 is a selective, potent and orall active 5-HT2C/2B receptor antagonist with pKi values of 6.9, 8.0 and 9.0 for 5-HT2A, 5-HT2B and 5-HT2C, respectively. SB228357 has antidepressant/anxiolytic effects [2].
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- HY-B0579
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- HY-125021
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2BAct
1 Publications Verification
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Eukaryotic Initiation Factor (eIF)
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Neurological Disease
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2BAct is a highly selective, and orally active eIF2B (eukaryotic initiation factor 2B) activator with an EC50 of 33 nM. 2BAct prevents neurological defects caused by a chronic integrated stress response. 2BAct is able to penetrate the central nervous system (CNS). 2BAct displays improved solubility and pharmacokinetics relative to eIF2B activator ISRIB trans-isomer (HY-12495) .
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- HY-11100
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Org 5222 maleate
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5-HT Receptor
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Neurological Disease
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Asenapine maleate is a 5-HT (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) and D2 antagonist with Ki values of 0.03-4.0 nM, 1.3nM, respectively, and an antipsychotic.
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- HY-157262
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Others
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Infection
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Methyl isonicotinate-(CH2)2-COOH (hapten 2b) is a hapten that can be activated with NHS and DCC. Methyl isonicotinate-(CH2)2-COOH has more immunogenicity and hydrophobicity .
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- HY-101043
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Sigma Receptor
iGluR
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Neurological Disease
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4-PPBP maleate is a potent σ 1 receptor ligand and agonist. 4-PPBP maleate is a non-competitive, selective NR1a/2B NMDA receptors (expressed in Xenopus oocytes) antagonist. 4-PPBP maleate provides neuroprotection [2] [3].
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- HY-P5829A
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Bacterial
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Infection
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CRAMP (140-173) (mouse) TFA is a ortholog of human LL-37 antimicrobial peptide. CRAMP (140-173) (mouse) TFA inhibits LPS (HY-D1056)-induced responses, and can not colocalized with TLR3 in BEAS-2B cells .
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- HY-148134
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Lipoxygenase
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Inflammation/Immunology
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5-LOX-IN-1 (compound 2b) is an inhibitor of human 5-Lipoxygenase (5-LOX) with an IC50 value of 2.3 μM. 5-LOX-IN-1 can be used for the research of inflammation .
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- HY-W205320
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- HY-P4046
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HIV
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Inflammation/Immunology
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HBV Seq2 aa:179-186 serve as effective motifs for CTL response in H-2b system after in vitro restimulation of the primed T cells. HBV Seq2 aa:179-186 is a novel epitope identified on the surface antigen of hepatitis B virus .
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- HY-158020
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DNA/RNA Synthesis
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Cancer
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Anticancer agent 197 (compound 2b) shows cell cytotoxicity with IC50 values of 10.03 µM and 73.54 µM for HL-60 cells and A549 cells, respectively. Anticancer agent 197 can induce DNA damage .
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- HY-150583
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Fungal
Antibiotic
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Inflammation/Immunology
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Chitin synthase inhibitor 2 (compound 2b) is a potent inhibitor of chitin synthase with the IC50 value of 0.09 mM and the Ki value of 0.12 mM. Chitin synthase inhibitor 2 has antimicrobial activities in vitro and shows synergistic or additive effects with fluconazole or polyoxin B .
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- HY-149512
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FGFR
VEGFR
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Cancer
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FGFR1/VEGFR2-IN-1 (compound 2b) is an FGFR1/VEGFR2 inhibitor. FGFR1/VEGFR2-IN-1 can be used for cancer research .
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- HY-146290
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Apoptosis
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Cancer
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Anticancer agent 46 (compound 2b) is a potent and selective anticancer agent. Anticancer agent 46 shows cytotoxicity activity in cancer cells. Anticancer agent 46 induces apoptosis. Anticancer agent 46 shows low toxicity towards activated lymphocytes of human blood .
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- HY-135785
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OGT
Acyltransferase
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Metabolic Disease
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OSMI-3 (Compound 2b) is a potent, long-lasting, and cell-permeable O-linked N-acetylglucosamine transferase (OGT) inhibitor. Cells contain a large nuclear pool of partially spliced OGT transcript, and OSMI-3 increases detained intron splicing in cells .
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- HY-139323
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- HY-B0579R
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Molecular Glues
Complement System
Antibiotic
Cyclophilin
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Inflammation/Immunology
Cancer
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Cyclosporin A (Standard) is the analytical standard of Cyclosporin A. This product is intended for research and analytical applications. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM [3]. Cyclosporin A also inhibits CD11a/CD18 adhesion .
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- HY-W011012
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Adenosine Receptor
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Metabolic Disease
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Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes [2] [3].
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- HY-W779188
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- HY-103155
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5-HT Receptor
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Neurological Disease
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SB 221284 is a selective 5-HT2C/2B receptor antagonist with pKi values are 6.4, 7.9 and 8.6 for 5-HT2A, 5-HT2B and 5-HT2C receptors, respectively. SB 221284 can be used for the research of neurological disease .
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- HY-U00391
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-
- HY-101514
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- HY-156330
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HIV
Cytochrome P450
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Infection
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HIV-IN-9 (Compound 2b) is a HIV inhibitor (IC50: 6.65 μg/mL), and has high binding affinity with HIV-RT. HIV-IN-9 also inhibits CYP3A4, CYP1A2, CYP2C1, and CYP2D6 .
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- HY-118829
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Drug Derivative
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Neurological Disease
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3,4-Methylenedioxy PV9 hydrochloride is a Cathinone derivative. 3,4-Methylenedioxy PV9 hydrochloride shows toxicity against BEAS-2B, human aortic endothelia, HASM, SK-N-SH, A172, HepG2, MKN45, and DLD1cells (LC50=12.8-67.5 μM) .
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- HY-162488
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Fungal
|
Infection
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Laccase-IN-3 (Compound 2b) is a laccase inhibitor (IC50 = 1.02= μM) with significant antifungal activity. Laccase-IN-3 shows superior inhibitory effect on Botryosphaeria dothidea (EC50 = 0.17 mg/L). Laccase-IN-3 effectively blocks the catalytic function of laccase by binding to its active center. Laccase-IN-3 also disrupts pathogen cell membrane integrity and increases ROS .
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- HY-D0113
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Reactive Oxygen Species
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Others
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7-Hydroxy-4-methyl-2(1H)-quinolone (compound 2b) is a fluorescent hydroxylated product. 7-Hydroxy-4-methyl-2(1H)-quinolone can be used for detecting hydroxyl radicals of DNA damage .
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- HY-16567
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5-HT Receptor
Dopamine Receptor
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Neurological Disease
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Asenapine hydrochloride, an antipsychotic, is a 5-HT (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) and Dopamine (D2, D3, D4) receptor antagonist with Ki values of 0.03-4.0 nM for 5-HT and 1.3, 0.42, 1.1 nM for Dopamine receptor, respectively.
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- HY-147922
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Carbonic Anhydrase
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Inflammation/Immunology
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hCAI/II-IN-2 (compound 2b) is a potent dual hCA I/II inhibitor with Ki values of 40.97, 15.15 and 61.88 nM for hCA I, hCA II and hCA Ⅸ. hCAI/II-IN-2 possesses anti-hypoxic activity against acute mountain sickness (AMS) and low cellular activity .
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- HY-19306
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Integrin
|
Cancer
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SB-267268 is a selective and nonpeptidic alpha(v)beta3 (αvβ3) and alpha(v)beta5 (αvβ5) integrins antagonist, with Kis of 0.9, 0.5 and 0.7 nM for human αvβ3, monkey αvβ3 and human αvβ5, respectively. SB-267268 inhibits human and mouse αvβ3 with IC50s of 0.68 and 0.29 nM, respectively. SB-267268 reduces angiogenesis and VEGF expression .
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- HY-161516
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HDAC
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Cancer
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HDAC6-IN-42 (compound 2b) is an HDAC6 inhibitor (IC50=0.009 μM). HDAC6-IN-42 shows significant anti-leukemia activity and synergistic effect with Decitabine (HY-A0004). HDAC6-IN-42 can be used for the AML research .
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- HY-143457
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NO Synthase
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Inflammation/Immunology
|
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Anti-inflammatory agent 19 (compound 2b) shows NO inhibitory activity, with an IC50 of 36.00 μM. Anti-inflammatory agent 19 inhibits HMGB1-induced later inflammation. Anti-inflammatory agent 19 can be used for the research of later inflammation diseases such as coronavirus diseases (COVID-19) and sepsis, etc .
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- HY-N10996
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Others
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Others
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(3β)-3-Hydroxyoleanan-12-one (compound 23) is a natural product that can be found in Codonopsis ovata .
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- HY-14148
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5-HT Receptor
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Neurological Disease
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Renzapride hydrochloride is a benzamide that inhibits irritable bowel syndrome and has antagonistic activity at 5-HT(3) receptors and agonistic activity at 5-HT(4) receptors. Renzapride hydrochloride also exhibits antagonistic activity at 5-HT(2B) receptors and has a certain affinity for 5-HT(2A) and 5-HT(2C) receptors .
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- HY-B0579S2
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Cyclosporine A acetate-d4; Ciclosporin A acetate-d4; CsA acetate-d4
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Isotope-Labeled Compounds
Antibiotic
Complement System
Molecular Glues
Cyclophilin
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Inflammation/Immunology
|
|
Cyclosporin A acetate-d4 (Cyclosporine A acetate-d4; Ciclosporin A acetate-d4) is a deuterium labeled Cyclosporin A (HY-B0579) . Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM [2]. Cyclosporin A also inhibits CD11a/CD18 adhesion [3].
|
-
- HY-116463C
-
|
|
Sigma Receptor
|
Neurological Disease
|
|
(2R,3R)-E1R (Compound 2b) is an enantiomer of E1R. (2R,3R)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders .
|
-
- HY-170378
-
|
|
Fungal
|
Infection
|
|
Laccase-IN-5 (Compound 2b) is the inhibitor for Laccase with an IC50 of 0.82 μM. Laccase-IN-5 increases the cell membrane permeability, limits the growth of hyphae, destorys the cell wall, and induces oxidative stress responses. Laccase-IN-5 exhibits antifungal activity against various plant pathogenic fungi and oomycetes, inhibits B. dothidea with an EC50 of 0.96 mg/L .
|
-
- HY-P10404
-
|
|
α-synuclein
|
Others
Neurological Disease
|
|
Pdpe 1.3 is a peptide inhibitor, The main activity is to destroy the direct interaction between α-synuclein and CHarged Multivesicular body Protein 2B (CHMP2B). By interfering with this interaction, PDpep1.3 restores the degradation function of the endocytosomes and lysosomes, thereby reducing alpha-synuclein levels and protecting dopaminergic neurons from alpha-synuclein mediated degradation. Pdpe 1.3 can be used in the study of neurodegenerative diseases and protein-protein interactions .
|
-
- HY-P2459
-
|
|
MHC
|
Neurological Disease
|
|
MOG (35-55), human is a component of CNS myelin. MOG (35-55), human is different from mMOG (35-55) by a proline for serine substitution at position 42. MOG (35-55), human is also immunogenic via bind to H-2b class II MHC and recognized by T cells, but not encephalitogenic, and is only partially cross-reactive with mMOG35–55. MOG (35-55), human induces minimal clinical signs of EAE relative to the rodent peptide [2].
|
-
- HY-W698354
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Gal1-β-3GlcNAc1-β-Ome is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-119886
-
|
|
iGluR
|
Neurological Disease
|
BMS-986169 is an inhibitor of the glutamate N-methyl-D-aspartate 2B receptor (GluN2B). BMS-986169 has a high binding affinity for the allosteric regulatory site of the GluN2B subunit, with a Ki value of 4.03-6.3 nM. BMS-986169 can inhibit the function of GluN2B receptors in Xenopus oocytes, with an IC50 value of 24.1 nM. BMS-986169 can also inhibit the activity of the hERG channel, with an IC50 value of 28.4 μM. BMS-986169 can be used in research on treatment-resistant depression .
|
-
- HY-157389
-
|
|
Bcr-Abl
|
Cancer
|
|
AK-HW-90 (compound 2B) is a potent panBcr-Abl inhibitor with significant inhibitory activity against Imatinib (HY-15463)-resistant mutants. AK-HW-90 inhibits the resistance mutant Bcr-Abl T315I with an IC50 of 0.65 nM. AK-HW-90 has potential anticancer activity and can be used in the study of chronic myelogenous leukemia (CML) .
|
-
- HY-135359R
-
|
|
Drug Metabolite
|
Neurological Disease
|
|
Adenosine 5'-monophosphate (disodium) (Standard) is the analytical standard of Adenosine 5'-monophosphate (disodium). This product is intended for research and analytical applications. Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes [2] [3].
|
-
- HY-169349
-
|
|
Androgen Receptor
|
Cancer
|
|
Androgen receptor antagonist 12 (Compound EF2) is an orally active Androgen receptor (AR) antagonist (IC50: 0.30 μM). Androgen receptor antagonist 12 inhibits transcriptional activity of variant AR mutants and and the proliferation of AR-positive PCa cell lines. Androgen receptor antagonist 12 blocks AR nuclear translocation. Androgen receptor antagonist 12 inhibits tumor growth in a C4-2B xenograft mouse model. Androgen receptor antagonist 12 can be used for prostate cancer (PCa) research .
|
-
- HY-W011012R
-
|
|
Adenosine Receptor
|
Metabolic Disease
|
|
Adenosine 5'-monophosphate (disodium) (Standard) is the analytical standard of Adenosine 5'-monophosphate (disodium). This product is intended for research and analytical applications. Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes [2] [3].
|
-
- HY-155764
-
|
|
COX
|
Cancer
|
|
COX-1/2-IN-4 (compound 2b) is anCOX inhibitorwith IC50 values of 0.239 μM and 0.191 μM for COX-1 enzyme and COX-2 enzyme , respectively. COX-1/2-IN-4showsmoderateanticanceractivity against COLO205 and B16F1 cancer cell lines with IC50 values of 30.79 and 74.15 μM, respectively .
|
-
- HY-16567S
-
|
|
Isotope-Labeled Compounds
5-HT Receptor
Dopamine Receptor
|
Neurological Disease
|
|
Asenapine- 13C,d3 (hydrochloride) is the 13C- and deuterium labeled Asenapine (hydrochloride). Asenapine hydrochloride, an antipsychotic, is a 5-HT (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) and Dopamine (D2, D3, D4) receptor antagonist with Ki values of 0.03-4.0 nM for 5-HT and 1.3, 0.42, 1.1 nM for Dopamine receptor, respectively.
|
-
- HY-N2921
-
|
(3β)-3-(Acetyloxy)olean-12-en-11-one; 11-Oxo-β-amyrin acetate
|
Others
|
Others
|
|
β-Amyrenonol acetate ((3β)-3-(Acetyloxy)olean-12-en-11-one) is a Triterpenoids product that can be isolated from the barks of Clausena excavata .
|
-
- HY-118574
-
|
|
iGluR
|
Neurological Disease
|
|
UBP141 is a GluN2C/2D (NR2C/2D)-preferring receptor antagonist, with Kds of 2.8, 4.2, 14.2, and 19.3 μM for NMDA receptor subtypes: GluN2C, 2D, 2A, and 2B, respectively. UBP141 can induce potent motor impairment in WT mice [2].
|
-
- HY-114204
-
|
|
Epigenetic Reader Domain
|
Cancer
|
|
GSK8814 is a potent, selective, and ATAD2/2B bromodomain chemical probe and inhibitor, with a binding constant pKd=8.1 and a pKi=8.9 in BROMOscan. GSK8814 binds to ATAD2 and BRD4 BD1 with pIC50s of 7.3 and 4.6, respectively. GSK8814 shows 500-fold selectivity for ATAD2 over BRD4 BD1 .
|
-
- HY-P4288
-
|
|
Amino Acid Derivatives
|
Others
|
|
Beta-Asp-His is a dipeptide containing aspartic acid and histidine, which can form amino acid derivatives by complexing with Zinc .
|
-
- HY-W357155
-
|
Galactosyl-N-acetylglucosaminyl-β-p-nitrophenyl
|
Biochemical Assay Reagents
|
Others
|
|
Gal1-β-3GlcNAc-β-PNP (Galactosyl-N-acetylglucosaminyl-β-p-nitrophenyl) is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-138026
-
-
- HY-133963
-
-
- HY-154864
-
-
- HY-146767S
-
-
- HY-166970
-
|
|
Biochemical Assay Reagents
|
Others
|
|
3α,4β,3α-Galactotetraose is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-B0579S3
-
|
Cyclosporine A-13C2,d4; Ciclosporin A-13C2,d4; CsA-13C2,d4
|
Isotope-Labeled Compounds
|
Inflammation/Immunology
|
|
Cyclosporin A- 13C2,d4 (Cyclosporine A- 13C2,d4; Ciclosporin A- 13C2,d4) is a 13C labeled Cyclosporin A (HY-B0579) . Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM [2]. Cyclosporin A also inhibits CD11a/CD18 adhesion [3].
|
-
- HY-W699180
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Fuc1-α-2Gal1-β-3GlcNAc-β-PNP is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-117792
-
|
|
5-HT Receptor
|
Inflammation/Immunology
|
|
LY314228 is an aminoguanidine 5-HT2 antagonist with relative selectivity for 5-HT2A receptors (IC50: 147.9 nM). The Ki values ??of LY314228 targeting different 5-HT subtypes are 65 nM (5-HT 2A), 1214 nM (5-HT 2B), and 168 nM (5-HT 2C), respectively. LY314228 is an effective inhibitor of 5-HT-induced paw edema in rats with an ED50 of 6.4 mg/kg in ovariectomized female rats. .
|
-
- HY-100014
-
|
|
Histone Demethylase
|
Cancer
|
|
KDM5A-IN-1 is a potent, orally bioavailable pan-histone lysine demethylases 5 (KDM5) inhibitor with IC50s of 45 nM, 56 nM and 55 nM for KDM5A, KDM5B and KDM5C, respectively, and with an EC50 value of 960 nM for PC9 H3K4Me3. KDM5A-IN-1 is significantly less potent against other KDM5B enzymes (1A, 2B, 3B, 4C, 6A, 7B) .
|
-
- HY-10238
-
|
ITMN-191; R7227; RO5190591; RG7227
|
HCV Protease
HCV
SARS-CoV
|
Infection
|
|
Danoprevir (ITMN-191) is an orally active NS3/4A protease inhibitor for hepatitis C virus (HCV) with an IC50 of 0.29 nM and is selective for NS3/4A over a panel of 53 proteases (IC50 higher than 10 μM). Danoprevir (ITMN-191) inhibits HCV genotypes 1a, 1b, 4, 5, and 6 (IC50s=0.2-0.4 nM) as well as 2b and 3a (IC50s=1.6, 3.5 nM) [2]. Danoprevir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 0.05 μM [3].
|
-
- HY-N8987
-
|
|
Others
|
Others
|
|
(3β,7β)-3,7,23,24-Tetrahydroxycucurbita-5,25-dien-19-al (compound 3) is a cucurbitane-type triterpenoid isolated from the vines and leaves of Momordica charantia .
|
-
- HY-130795
-
|
|
GSK-3
|
Neurological Disease
|
|
GSK-3β inhibitor 2 (Compound 3) is a potent, selective and orally active GSK-3β inhibitor with an IC50 of 1.1 nM. GSK-3β inhibitor 2 can cross the blood-brain barrier. GSK-3β inhibitor 2 has the potential for Alzheimer's disease .
|
-
- HY-P4885
-
|
AβpE3-40
|
Amyloid-β
|
Neurological Disease
|
|
Glp-Amyloid-β (3-40) Peptide (human) (AβpE3-40) is a minor amounts of pyroglutamate-modified Aβ isolated from from 24-month-old Amyloid precursor protein (APP) transgenic Mice .
|
-
- HY-161783
-
|
|
HDAC
Keap1-Nrf2
Reactive Oxygen Species
Apoptosis
|
Neurological Disease
|
|
HDAC6-IN-45 (Compound 15) is a selective inhibitor for HDAC6 with IC50 of 15.2 nM. HDAC6-IN-45 exhibits neurotrophic through the upregulation of GAP43 and Beta-3 tubulin markers. HDAC6-IN-45 activates the Nrf2 signaling pathway, reduces H2O2-induced ROS production, inhibits apoptosis in PC12, and exhibits neuroprotective efficacy in SCOP-induced zebrafish Alzheimer's Disease models. HDAC6-IN-45 exhibits antioxidant activity and good blood-brain barrier (BBB) permeability .
|
-
- HY-P10605
-
|
|
Akt
GSK-3
|
Cancer
|
|
GSK3β-peptide is a substrate mimetic peptide of glycogen synthase kinase 3-β (GSK3-β) that can bind to the active site of GSK3-β and mimic the behavior of a real substrate. GSK3β-peptide can be used to develop substrate mimetic inhibitors of Akt as potential anticancer drugs .
|
-
- HY-159921
-
|
|
Microtubule/Tubulin
|
Cancer
|
|
Tubulin Polymerization-IN-1 prodrug (Compound 2b) is a palladium (Pd)-mediated tubulin polymerization inhibitor prodrug. Developed based on colchicine binding site inhibitors (CBSIs), it reduces toxicity and enhances targeted release properties. Compared to the parent compound, Tubulin Polymerization-IN-1 prodrug exhibited 68.3-fold lower cytotoxicity, which can be restored in situ in the presence of Pd resin. Mechanistic studies showed that its anticancer activity is consistent with CBSIs. In vivo, Tubulin Polymerization-IN-1 prodrug significantly inhibited tumor growth (63.2%) when activated by Pd resin. It holds promise for research in the field of anticancer therapy .
|
-
- HY-149054
-
|
|
GSK-3
Tau Protein
AAK1
Pim
PKC
|
Neurological Disease
|
|
GSK-3β inhibitor 13 (compound 47) is an orally active and potent GSK-3β inhibitor with blood-brain permeability. GSK-3β inhibitor 13 inhibits GSK-3β and GSK-3α with IC50s of 0.73 nM and 0.35 nM, respectively. GSK-3β inhibitor 13 significantly decreases the phosphorylation of tau (IC50=58 nM), which leads the formation of the neurofibrillary tangles associated with Alzheimer's disease .
|
-
- HY-N6058
-
|
|
Parasite
|
Others
|
|
(3β)-3-[(O-β-D-Glucopyranosyl-(1→3)-O-6-deoxy-α-L-mannopyranosyl-(1→2)-α-L-arabinopyranosyl)oxy]olean-12-en-28-oic acid is a member of Oleanolic acid saponins with trematocide activity .
|
-
![(3β)-3-[(O-β-D-Glucopyranosyl-(1→3)-O-6-deoxy-α-L-mannopyranosyl-(1→2)-α-L-arabinopyranosyl)oxy]olean-12-en-28-oic acid](//file.medchemexpress.com/product_pic/hy-n6058.gif)
- HY-108790
-
|
Peginterferon β-1a
|
Apoptosis
|
Neurological Disease
Cancer
|
|
Peginterferon beta-1a (Peginterferon β-1a) is the first pegylated interferon beta-1a molecule. Peginterferon beta-1a induces cancer cells apoptosis and shows anti-tumor activities in nude mice models. Peginterferon beta-1a can be used for the research of cancer and multiple sclerosis (RMS) .
|
-
- HY-N10893
-
|
|
Others
|
Others
|
|
(-)-β-Peltatin-5-O-beta-D-glucopyranoside is an active compound. (-)-β-Peltatin-5-O-beta-D-glucopyranoside can be isolated from P. peltatum L .
|
-
- HY-124208A
-
-
- HY-124208
-
-
- HY-157959
-
|
(±)-Orphenadrine
|
iGluR
Cytochrome P450
Cholinesterase (ChE)
|
Neurological Disease
Cancer
|
|
Orphenadrine ((±)-Orphenadrine) is a skeletal muscle relaxant and NMDA antagonist that also has antiparkinsonian, antihistamine, antitremor, antispasmodic, and analgesic effects. Orphenadrine inhibits the binding of [3H]MK-801 to the phencyclidine (PCP) binding site of the NMDA receptor. Orphenadrine is also an anticholinergic and cytochrome P450 (CYP) 2B inducer. Orphenadrine may exert pro-tumor effects, causing CAR nuclear translocation, resulting in microsomal reactive oxygen species (ROS) production and oxidative stress. Orphenadrine also exerts neuronal protection, protecting rat cerebellar granule cells (CGC) from 3-NPA-induced death and has inhibitory potential against neurodegenerative diseases mediated by NMDA receptor overactivation [2] [3].
|
-
- HY-148133
-
|
|
GSK-3
|
Neurological Disease
|
|
GSK-3β inhibitor 12 (compound 15) is an inhibitor of GSK-3β. GSK-3β inhibitor 12 inhibits 49.11% and 37.11% activity of 25 μM and 50 μM GSK-3β, respectively. GSK-3β inhibitor 12 can be used for the research of neurodegenerative diseases .
|
-
- HY-148132
-
|
|
GSK-3
|
Neurological Disease
|
|
GSK-3β inhibitor 11 (compound 21) is a glycogen synthase kinase-3β (GSK-3β) inhibitor (IC50=10.02 μM). GSK-3β inhibitor 11 can be used in neurodegenerative disease research .
|
-
- HY-149542
-
|
|
Tau Protein
Apoptosis
GSK-3
|
Neurological Disease
|
|
GSK-3β inhibitor 15 (Compound 54) is a GSK-3β inhibitor (IC50: 3.4 nM). GSK-3β inhibitor 15 inhibits Aβ1-42-induced GSK-3β and tau protein phosphorylation. GSK-3β inhibitor 15 inhibits LPS-induced iNOS expression. GSK-3β inhibitor 15 has neuroprotective effects on Aβ1-42-induced neurotoxicity. GSK-3β inhibitor 15 can be used for research of Alzheimer’s disease (AD) .
|
-
- HY-168857
-
|
|
GSK-3
Tau Protein
β-catenin
|
Neurological Disease
|
|
GSK-3β inhibitor 24 (Compound 41) is a potent GSK-3β inhibitor with IC50 of 0.22 nM. GSK-3β inhibitor 24 increases GSK-3β phosphorylation at Ser9 site dose-dependently. GSK-3β inhibitor 24 inhibits the hyperphosphorylation of tau protein by decreasing the p-tau-Ser396 abundance. GSK-3β inhibitor 24 up-regulates β-catenin and neurogenesis-related markers (GAP43 and MAP-2). GSK-3β inhibitor 24 demonstrates remarkable anti-Alzheimer's disease (AD) effects .
|
-
- HY-149845
-
|
|
GSK-3
PROTACs
|
Neurological Disease
|
|
PROTAC GSK-3β Degrader-1 (compound 1) is a degrader targets GSK-3β degradation with an IC50 value of 833 nM. PROTAC GSK-3β Degrader-1 contains SB-216763 (a GSK-3β inhibitor), a PEG linker and a CRBN (E3 ligase liand). PROTAC GSK-3β Degrader-1 reduces the neurotoxicity induced by Aβ25-35 peptide and CuSO4. PROTAC GSK-3β Degrader-1 can be used to research in Alzheimer's disease .
|
-
- HY-164907
-
|
|
GSK-3
|
Neurological Disease
|
|
GSK-3β inhibitor 22 (compound 20o) is a GSK-3β inhibitor with an IC50 of 3.1 nM. GSK-3β inhibitor 22 has the potential of the study of Alzheimer's disease .
|
-
- HY-164138
-
|
|
17β-HSD
|
Cancer
|
|
17β-HSD5 inhibitor 3 (Compound 31) is an orally active inhibitor for 17β-HSD5 with an IC50 of 69 nM .
|
-
- HY-169024
-
-
- HY-143261
-
|
|
GSK-3
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
GSK-3β inhibitor 7 is a GSK-3β inhibitor with an IC50 value of 5.25 μM. GSK-3β inhibitor 7 is inserted into the ATP-binding binding pocket of GSK-3β and forms hydrogen-bond. GSK-3β inhibitor 7 shows high hepatocyte glucose uptake (83.5%), and can be used in the research of numerous diseases like diabetes, inflammation, cancer, Alzheimer's disease, and bipolar disorder .
|
-
- HY-147134
-
|
|
GSK-3
|
Neurological Disease
|
|
GSK-3β inhibitor 10 (compound 14a) is a highly potent GSK-3β inhibitor with an IC50 value of 80.5 nM. GSK-3β inhibitor 10 can be used for researching Alzheimer’s disease .
|
-
- HY-169602
-
-
- HY-143260
-
|
|
GSK-3
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
GSK-3β inhibitor 6 is a potent GSK-3β inhibitor with an IC50 value of 24.4 μM. GSK-3β inhibitor 6 shows high hepatocyte glucose uptake (38%). GSK-3β inhibitor 6 can be used in the research of numerous diseases like diabetes, inflammation, cancer, Alzheimer's disease, and bipolar disorder .
|
-
- HY-120902
-
|
|
GSK-3
|
Inflammation/Immunology
|
|
GSK-3β inhibitor 8, a thiophenacil derivative, is an effective and selective inhibitor of GSK-3β (IC50=64 nM). GSK-3β inhibitor 8 negatively regulated Wnt signaling pathway and stimulated β cell proliferation [2].
|
-
- HY-141480
-
|
|
GSK-3
Apoptosis
|
Cancer
|
|
GSK-3β inhibitor 3 is a potent, selective, irreversible and covalent inhibitor of Glycogen Synthase Kinase 3β (GSK-3β), with an IC50 of 6.6 μM. GSK-3β inhibitor 3 can be used for the research of acute promyelocytic leukemia .
|
-
- HY-126144
-
|
|
GSK-3
|
Metabolic Disease
Cancer
|
|
GSK-3β inhibitor 1 (compound 3a) inhibits GSK-3β with an IC50 of 4.19 nM. GSK-3β inhibitor 1 demonstrates high antidiabetic efficacy in obese Streptozotocin (HY-13753)-treated rats .
|
-
- HY-162638
-
-
- HY-163748
-
|
|
GSK-3
|
Inflammation/Immunology
|
|
GSK-3β inhibitor 17 (compound 5 n) is a potent GSK-3β inhibitor. GSK-3β inhibitor 17 decreases cisplatin (HY-17394) induced p-p65, KIM-1 protein and mRNA expression. GSK-3β inhibitor 17 decreases cisplatin induced TNF-α, IL-1β, IL-6 and MCP-1 mRNA expression. GSK-3β inhibitor 17 shows anti-inflammation effect and has the potential for the research of acute kidney injury .
|
-
- HY-162913
-
|
|
GSK-3
|
Neurological Disease
|
|
GSK-3β inhibitor 20 (compound 3A) is an potent inhibitor of GSK-3β with an IC50 value of 74.4 nM .
|
-
- HY-P4886
-
|
|
Amyloid-β
|
Neurological Disease
|
|
Amyloid β-Protein (3-42) is the precursor of Pyr peptide. Pyroglutamate-modified Aβ (pEAβ) (3-42) is the core of the amyloid template block in Alzheimer's disease. pEAβ(3-42) accelerated the aggregation of Aβ(1-42), while Aβ(1-42) significantly slowed the primary and secondary nucleation of pEAβ(3-42) .
|
-
- HY-153760
-
-
- HY-168079
-
|
|
GSK-3
Tau Protein
|
Neurological Disease
Inflammation/Immunology
|
|
GSK-3β inhibitor 21 (compound 44) is an ATP-competitive GSK-3β inhibitor (IC50=6.06 μM) with anti-amyloid aggregation and tau phosphorylation inhibitory activities. GSK-3β inhibitor 21 can be used in the study of Alzheimer's disease .
|
-
- HY-161458
-
|
|
GSK-3
Tau Protein
|
Neurological Disease
|
|
GSK-3β inhibitor 16 (compound 7c) is a GSK-3β inhibitor with the IC50 of 4.68 nM. GSK-3β inhibitor 16 decreases Tau hyperphosphorylated aggregate and alleviates cognitive impairments in the Scopolamin (HY-N0296)-induced model in mice .
|
-
- HY-169632
-
|
|
GSK-3
|
Neurological Disease
|
|
GSK3β-IN-1 (compound 1) is a glycogen synthase kinase-3β (GSK-3β) inhibitor (IC50=65 nM), which can be used in the study of Alzheimer's disease .
|
-
- HY-114319
-
|
|
Others
|
Cancer
|
|
β-Cembrenediol is a potent and orally active anticancer agent. β-Cembrenediol shows phytotoxic activities. β-Cembrenediol reduces the migration and colony formation. β-Cembrenediol decreases the protein expression of TDO2, IDO1. β-Cembrenediol has the potential for the research of prostate cancer [2].
|
-
- HY-P4886A
-
|
|
Amyloid-β
|
Neurological Disease
|
|
Amyloid β-Protein (3-42) TFA is a precursor of Pyr peptide. Pyroglutamic acid-modified Aβ (pEAβ) (3-42) is the core of the amyloid plaque in Alzheimer's disease. pEAβ (3-42) accelerates the aggregation of Aβ(1-42), while Aβ(1-42) significantly slows down the primary and secondary nucleation of pEAβ(3-42).
|
-
- HY-148533
-
|
|
mAChR
Adrenergic Receptor
|
Neurological Disease
|
|
β2AR agonist /M-receptor antagonist-1 is a potent dual muscarinic antagonist/beta 2 agonist (MABA). β2AR agonist /M-receptor antagonist-1 potently relaxes either Carbachol (HY-B1208)-induced contraction, in the absence (MABA) or presence of Propranolol (M3; HY-B1208), or Histamine (HY-B1204)-induced contraction (β2) [2].
|
-
- HY-N10593
-
|
|
Reactive Oxygen Species
|
Cardiovascular Disease
|
|
Ladanetin-6-O-β-D-glucopyranoside is an active flavonoid. Ladanetin-6-O-β-D-glucopyranoside has antioxidative effect. Ladanetin-6-O-β-D-glucopyranoside can be used for the research of cardioprotective effects .
|
-
- HY-169606
-
-
- HY-170491
-
|
|
GSK-3
|
Infection
Neurological Disease
|
|
GSK-3β inhibitor 23 (Compound 11726169) is the inhibitor for glycogen synthase kinase-3, that inhibits GSK-3β and GSK-3α with IC50 of 12.1 nM and 18.8 nM. GSK-3β inhibitor 23 exhibits antiviral activity against HIV 1. GSK-3β inhibitor 23 exhibits good metabolic stablility in mouse/human liver microsomes and plasma, but poor Caco-2 permeability (which predicts low oral bioavailability) .
|
-
- HY-W152862S
-
|
Alpha-cyano-3-phenoxybenzyl [1R-[1alpha(R*),3beta]]-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate-d5
|
Isotope-Labeled Compounds
|
Others
|
|
Beta-cypermethrin-d5 (Alpha-cyano-3-phenoxybenzyl [1R-[1alpha(R*),3beta]]-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate-d5) is deuterium labeled Beta-cypermethrin .
|
-
- HY-120704
-
|
|
Mps1
|
Cancer
|
|
Mps-BAY2b is a oral active monopolar spindle 1 (MPS1) inhibitor with the IC50 of 14 nM (human MPS1). Mps-BAY2b shows anticancer activity and can be used for study of cancer .
|
-
- HY-147203
-
|
|
5-HT Receptor
|
Cardiovascular Disease
Metabolic Disease
Endocrinology
Cancer
|
|
5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 value of 33.4 nM. 5-HT2B antagonist-1 can be used in studies of diseases characterized by 5-HT2B receptor signaling, such as hepatocellular carcinoma, cardiovascular disease or gastrointestinal disease [2].
|
-
- HY-E70449
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Salt active endonuclease is a general, unspecific endonuclease that cleaves double-stranded and single-stranded DNA, and RNA. Salt active endonuclease can be used to remove DNA during protein expression and purification .
|
-
- HY-126144A
-
|
|
GSK-3
|
Metabolic Disease
|
|
(E/Z)-GSK-3β inhibitor 1 is a racemic compound of (E)-GSK-3β inhibitor 1 and (Z)-GSK-3β inhibitor 1 isomers. GSK-3β inhibitor 1 (compound 3a) is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy, with an IC50 of 4.9 nM .
|
-
- HY-P3713
-
|
|
GSK-3
|
Cancer
|
|
Presenilin 1 (349-361) is an active petide, and synthetic peptides representing amino acids 349–361 can be phosphorylated by glycogen synthase kinase-3β(GSK3β) in vitro. Presenilin 1 (349-361) can be used for the research of various diseases .
|
-
- HY-N11706
-
|
(+)-β-Cedrene
|
Fungal
|
Infection
Inflammation/Immunology
|
|
β-Cedrene ((+)-β-Cedrene) is a sesquiterpene compound that can be isolated from Centaurea kotschyi var. kotschyi and Centaurea kotschyi var. decumbens, exhibiting antibacterial, anti-inflammatory, antispasmodic, tonic, diuretic, sedative, insecticidal, and antifungal activities. β-Cedrene is also a potent competitive inhibitor of the CYP2B6-mediatedbupropion hydroxylase, with a Ki value of 1.6 μM [2].
|
-
- HY-N9587
-
|
|
Apoptosis
|
Neurological Disease
|
|
Tricin 7-O-β-D-glucopyranoside is a potent and orally active neuroprotective agent. Tricin 7-O-β-D-glucopyranoside induces Apoptosis. Tricin 7-O-β-D-glucopyranoside decreases the expression of TNF-α induced phosphor-κB-α, phosphor-NF-κB, HMGB1 .
|
-
- HY-149967
-
|
|
iGluR
|
Neurological Disease
Inflammation/Immunology
|
|
GluN2B-NMDAR antagonist-1 is an orally active GluN2B-NMDAR antagonist. GluN2B-NMDAR antagonist-1 has neuroprotective activity. GluN2B-NMDAR antagonist-1 can be used for research of ischemic injury .
|
-
- HY-N0236
-
Corylin
5 Publications Verification
|
Antibiotic
STAT
|
Infection
Metabolic Disease
Cancer
|
|
Corylin is an orally active flavonoid anti-inflammatory and osteogenic agent that inhibits IL-6-induced STAT3 promoter activity and STAT3 phosphorylation. Corylin also has anticancer, antiatherosclerotic, and ameliorating activity in hyperlipidemia and insulin resistance, inducing adipocyte browning and lipolysis through SIRT1 or β3-AR-dependent pathways [2] [3].
|
-
- HY-123495
-
-
- HY-P1897
-
|
|
Integrin
|
Inflammation/Immunology
|
|
Fibronectin Active Fragment Control is an active peptide fragment of fibronectin. Fibronectin is a glycoprotein interacting with integrins .
|
-
- HY-N8126
-
|
Glucoemodin
|
Others
|
Metabolic Disease
Inflammation/Immunology
|
|
Emodin-6-O-β-D-glucoside (Glucoemodin) is an active compound from Reynoutria japonica. Emodin-6-O-β-D-glucoside shows potent anti-inflammatory and barrier protective effects. Emodin-6-O-β-D-glucoside can be used for the research of diabetic complications and atherosclerosis .
|
-
- HY-19764
-
|
|
RIP kinase
|
Cancer
|
|
GSK2983559 active metabolite is an active metabolite of GSK2983559. GSK2983559 active metabolite is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043446 A1, compound example 1.
|
-
- HY-168924
-
|
|
Wnt
β-catenin
|
Metabolic Disease
|
|
Wnt/β-catenin activator 1 (Compound 5m) is the orally active activator for Wnt/β-catenin signaling pathway, that arrests cell cycle at G1 phase, inhibits early proliferation of adipocytes, and inhibits adipogenesis in cell 3T3-L1 with an IC50 of 330 nM. Wnt/β-catenin activator 1 exhibits anti-adipogenic and anti-dyslipidemic activities in high-fat diet fed Syrian golden hamster model .
|
-
- HY-10315
-
|
RWJ-53308
|
Integrin
|
Cardiovascular Disease
|
|
Elarofiban (RWJ-53308) is a nonpeptide, orally active antagonist for fibrinogen receptor αIIbβ3 (GPIIb/IIIa), with an IC50 of 0.15 nM. Elarofiban has the potential for platelet mediated thrombotic disorders research .
|
-
- HY-E70179
-
|
EC 2.4.1.149; B4GAT1; β3GNTI
|
Glucosylceramide Synthase (GCS)
|
Others
|
|
beta-1,4-Glucuronyltransferase 1 is a glucosyltransferase. beta-1,4-Glucuronyltransferase 1 transfers glucuronic acid towards both α and β anomers of xylose .
|
-
- HY-P5542
-
-
- HY-127010
-
-
- HY-N0988
-
|
|
Others
|
Cancer
|
|
1β,4β,7α-Trihydroxyeudesmane (compound 4) is a nature product that could be isolated from the rhizomes of Homalomena occulta. 1β,4β,7α-Trihydroxyeudesmane has antiproliferative active. 1β,4β,7α-Trihydroxyeudesmane can be used in research of cancer .
|
-
- HY-N0236R
-
|
|
Antibiotic
STAT
|
Infection
Metabolic Disease
Cancer
|
|
Corylin (Standard) is the analytical standard of Corylin. This product is intended for research and analytical applications. Corylin is an orally active flavonoid anti-inflammatory and osteogenic agent that inhibits IL-6-induced STAT3 promoter activity and STAT3 phosphorylation. Corylin also has anticancer, antiatherosclerotic, and ameliorating activity in hyperlipidemia and insulin resistance, inducing adipocyte browning and lipolysis through SIRT1 or β3-AR-dependent pathways [2] [3].
|
-
- HY-Y1750A
-
-
- HY-Y1750
-
-
- HY-P4211
-
|
|
Bacterial
|
Infection
|
|
PSM-β is a active peptide , which can be isolated from Staphylococcus epidermidis. PSM-β is an analog of staphylococcal toxins, as well as a termed phenol-soluble modulin. PSM-β has bacteriostatic and poorly hemolytic properties [2].
|
-
- HY-N13719
-
|
|
Others
|
Others
|
|
Tectorigenin 7-O-β-D-glucosyl-(1→6)-β-D-glucoside is an active compound.
|
-
- HY-P2770
-
|
|
Endogenous Metabolite
|
Others
|
|
β-Amylase, Bacilus subtilis has abundant starch degrading activities. β-Amylase can be used for various biochemical studies .
|
-
- HY-B1837A
-
|
beta-Cyfluthrin
|
Calcium Channel
|
Neurological Disease
|
|
β-Cyfluthrin (beta-Cyfluthrin) is a type II synthetic pyrethroid and also an active ingredient of many insecticide products used for pestsin agriculture. β-Cyfluthrin is a neurotoxicant and affects calcium concentration in nervous tissue by inhibiting Ca 2+ ATPase involved in calcium transport .
|
-
- HY-N8573
-
|
|
Bacterial
|
Infection
|
|
β-phellandrene is an orally active monocyclic monoterpenes. β-Phellandrene is obtained from Carum petroselinum. β-phellandrene has strong ability to kill pest. β-phellandrene can be used as oil additives, natural pesticides and synthetic materials [2].
|
-
- HY-133707
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
β-Muricholic acid is a potent and orally active biliary cholesterol-desaturating agent. β-Muricholic acid prevents cholesterol gallstones. β-Muricholic acid inhibits lipid accumulation. β-Muricholic acid has the potential for the research of nonalcoholic fatty liver disease (NAFLD) [2].
|
-
- HY-P990301
-
|
|
Amyloid-β
|
Others
|
|
Anti-Human/Mouse/Rat Amyloid-beta Antibody (MOAB-2) is a mouse-derived IgG2b, λ type antibody inhibitor, targeting to Amyloid-beta.
|
-
- HY-170417
-
|
|
Cholinesterase (ChE)
GSK-3
|
Neurological Disease
|
|
hAChE/hBuChE/GSK-3β-IN-1 (Compound 6c) is a BBB-penatrable and multi-target anti-Alzheimer's disease compound. hAChE/hBuChE/GSK-3β-IN-1 is the inhibitors of hAChE (IC50: 28.88 nM), hBuChE (IC50: 131.90 nM) and GSK-3β (IC50: 51.42 nM). hAChE/hBuChE/GSK-3β-IN-1 is the tau and Aβ protein aggregation inhibitors .
|
-
- HY-B1837AR
-
|
beta-Cyfluthrin (Standard)
|
Calcium Channel
|
Neurological Disease
|
|
β-Cyfluthrin (Standard) is the analytical standard of β-Cyfluthrin. This product is intended for research and analytical applications. β-Cyfluthrin (beta-Cyfluthrin) is a type II synthetic pyrethroid and also an active ingredient of many insecticide products used for pestsin agriculture. β-Cyfluthrin is a neurotoxicant and affects calcium concentration in nervous tissue by inhibiting Ca 2+ ATPase involved in calcium transport .
|
-
- HY-P990327
-
|
|
TGF-β Receptor
|
Inflammation/Immunology
|
|
The Anti-ACVR2B Antibody is a human antibody expressed in CHO cells, targeting ACVR2B. The Anti-ACVR2B Antibody has huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 144.42 kDa. The isotype control for the Anti-ACVR2B Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-10315A
-
|
|
Integrin
|
Cardiovascular Disease
|
|
Elarofiban diTFA is the salt form of Elarofiban (HY-10315) with two TFA. Elarofiban diTFA is a nonpeptide, orally active antagonist for fibrinogen receptor αIIbβ3 (GPIIb/IIIa), with an IC50 of 0.15 nM. Elarofiban diTFA has the potential for platelet mediated thrombotic disorders research [2].
|
-
- HY-160078
-
|
|
Others
|
Metabolic Disease
|
|
Deferiprone O-β-D-glucuronide is a novel orally active iron chelator. Deferiprone O-β-D-glucuronide shows the capability of reducing the iron burden in patients with β-thalassemia .
|
-
- HY-161667
-
|
|
GSK-3
HDAC
|
Neurological Disease
|
|
GSK-3β/HDAC-IN-1 (Compd 4) is a brain-penetrant and first in class dual non-ATP-competitive Glycogen Synthase Kinase 3β/Histone Deacetylases (GSK-3β/HDACs) Inhibitor with IC50s of 0.142, 0.03 and 0.045 μM against GSK-3β, HDAC2 and HDAC6, respectively. GSK-3β/HDAC-IN-1 can be used for Alzheimer’s disease research .
|
-
- HY-117239
-
|
|
Adrenergic Receptor
|
Cardiovascular Disease
|
|
SB-206606, a stereoisomer of BRL 37344, is a potentially specific, beta 3-adrenergic receptor (β3-AR) ligand. The affinity of [3H]SB 206606 is 76 times higher for the β3-AR than for the beta 1/beta 2-adrenergic receptors .
|
-
- HY-P5997
-
|
|
Autophagy
Cyclic GMP-AMP Synthase
|
Inflammation/Immunology
|
|
XQ2B is a specific cGAS inhibitor targeting protein-DNA interaction and phase separation. XQ2B markedly reduces ISD-induced Autophagy. XQ2B inhibits herpes simplex virus 1 (HSV-1)-induced antiviral immune responses and enhances HSV-1 infection .
|
-
- HY-19933
-
|
MK-4618
|
Adrenergic Receptor
|
Others
|
|
Vibegron (MK-4618) is a potent, highly selective and orally active β3-adrenoceptor agonist (EC50=1.1 nM). Vibegron can be used for severe urgency urinary incontinence related to overactive bladder [2] [3].
|
-
- HY-122084
-
-
- HY-N2922
-
|
|
Amyloid-β
NF-κB
|
Neurological Disease
Inflammation/Immunology
|
|
β-Amyrin shows effectively counteract amyloid β (Aβ)-induced impairment of long-term potentiation (LTP). β-Amyrin is a promising candidate for Alzheimer's disease (AD) research. β-Amyrin exhibits anti-inflammatory effects, protective activity against pulmonary fibrosis, and notable antibacterial capabilities. β-Amyrin is an orally active natural triterpenoid compound [2] [3] .
|
-
- HY-P1362
-
|
Amyloid β Peptide (42-1)(human)
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (42-1), human is the inactive form of Amyloid β Peptide (1-42). Its active form, β-Amyloid (1-42), may play a key role in the pathogenesis of Alzheimer's disease .
|
-
- HY-126083
-
|
Wortmannin-17β-ol
|
PI3K
|
Others
Cancer
|
|
17β-Hydroxywortmannin (Wortmannin-17β-ol) is an orally active inhibitor for phosphatidylinositol-3-kinase (PI-3-kinase) with an IC50 of 0.5 nM, suppresses the osteoclast resorption with an IC50 of 10 nM . 17β-Hydroxywortmannin exhibits antitumor activity [2].
|
-
- HY-140513
-
|
|
PROTAC Linkers
|
Cancer
|
|
Active-mono-sulfone-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-P1189
-
|
|
Integrin
|
Metabolic Disease
Inflammation/Immunology
|
|
Echistatin, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of αIIbβ3, αvβ3 and α5β1 [2] [3] .
|
-
- HY-P1189A
-
|
|
Integrin
|
Metabolic Disease
Inflammation/Immunology
|
|
Echistatin TFA, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of αIIbβ3, αvβ3 and α5β1 [2] [3] .
|
-
- HY-123712
-
-
- HY-N10013
-
|
|
Insecticide
|
Others
|
|
β-Damascone is an aroma active rice volatile and is widely used in perfume compositions. β-Damascone has also received certain attention as a potential cancer chemopreventive and a mosquito and muscoid insecticide [2].
|
-
- HY-139561
-
-
- HY-N10639
-
|
|
Others
|
Others
|
|
(1α,2α,6β,8α,9α)-1,2,6,8,12-Pentakis(acetyloxy)-9-(benzoyloxy)dihydro-β-agarofuran is a sesquiterpene polyol ester. (1α,2α,6β,8α,9α)-1,2,6,8,12-Pentakis(acetyloxy)-9-(benzoyloxy)dihydro-β-agarofuran can be used for the research of various biochemical .
|
-
- HY-P4391
-
-
- HY-137553A
-
|
SM934
|
NOD-like Receptor (NLR)
|
Inflammation/Immunology
|
|
β-Aminoarteether maleate (SM934) is an Artemisinin derivative with orally active. β-Aminoarteether maleate can be used for inflammation and autoimmune disease research, such as lupus diseases .
|
-
- HY-N13718
-
|
|
Others
|
Others
|
|
Irisolidone 7-O-β-D-glucopyranoside is an active compound.
|
-
- HY-N10013R
-
|
|
Insecticide
|
Others
|
|
β-Damascone (Standard) is the analytical standard of β-Damascone. This product is intended for research and analytical applications. β-Damascone is an aroma active rice volatile and is widely used in perfume compositions. β-Damascone has also received certain attention as a potential cancer chemopreventive and a mosquito and muscoid insecticide [2].
|
-
- HY-N2922R
-
|
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyrin shows effectively counteract amyloid β (Aβ)-induced impairment of long-term potentiation (LTP). β-Amyrin is a promising candidate for Alzheimer's disease (AD) research. β-Amyrin exhibits anti-inflammatory effects, protective activity against pulmonary fibrosis, and notable antibacterial capabilities. β-Amyrin is an orally active natural triterpenoid compound [2] [3] .
|
-
- HY-U00303
-
-
- HY-137197
-
-
- HY-157561
-
-
- HY-103081
-
|
|
Bacterial
|
Infection
Cancer
|
|
β-Glucuronidase-IN-1 is a potent, selective, uncompetitive, and orally active E. coli bacterial β-glucuronidase inhibitor, exhibiting an IC50 and a Ki of 283 nM and 164 nM, respectively .
|
-
- HY-108549
-
|
Omuralide; β-Clastolactacystin
|
Proteasome
|
Cancer
|
|
Clasto-Lactacystin β-lactone, a natural active metabolite of lactacystin, which is a metabolite of Streptomyces, acts as an irreversible 20S proteasome inhibitor.
|
-
- HY-168453
-
|
|
PROTACs
Epigenetic Reader Domain
|
Cancer
|
|
dBAZ2B is a BAZ2B PROTAC degrader, with a DC50 of 19 nM . (Pink: BAZ2A/B ligand (HY-168449); Black: linker (HY-168450); Blue: CRBN Ligand (HY-125905))
|
-
- HY-139601
-
|
|
Histone Demethylase
|
Cancer
|
|
KDM2B-IN-4 is a histone demethylase KDM2B inhibitor extracted from patent WO2016112284A1, compound 182b. KDM2B-IN-4 can be used for the research of cancer .
|
-
- HY-139600
-
|
|
Histone Demethylase
|
Cancer
|
|
KDM2B-IN-3 is a histone demethylase KDM2B inhibitor extracted from patent WO2016112284A1, compound 183c. KDM2B-IN-3 can be used for the research of cancer .
|
-
- HY-139560
-
-
- HY-19307
-
|
|
Integrin
|
Inflammation/Immunology
|
|
SB-273005 is a potent nonpeptide and orally active integrin antagonist with Kis of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively .
|
-
- HY-118944
-
|
|
Adrenergic Receptor
|
Endocrinology
|
|
L-748328 is a potent and selective human β3-adrenergic receptor antagonist. L-748328 has a Ki of 3.7 nM against human cloned β3-AR expressed in Chinese hamster ovary (CHO) cells. In addition, L-748328 inhibits the lipolytic response induced by the β3-AR agonist L-742791 in isolated non-human primate adipocytes .
|
-
- HY-N1501
-
-
- HY-11012
-
|
GSK-3β Inhibitor I; NP 01139
|
GSK-3
|
Cancer
|
|
TDZD-8 is an inhibitor of GSK-3β, with an IC50 of 2 μM; TDZD-8 shows less potent activities against Cdk-1/cyclin B, CK-II, PKA, and PKC, with all IC50s of >100 μM.
|
-
- HY-150537
-
|
|
Cholinesterase (ChE)
GSK-3
Microtubule/Tubulin
ROS Kinase
|
Neurological Disease
|
|
AChE/GSK-3β-IN-1 (compound GT15) is a potent, dual AChE/GSK-3β inhibitor with IC50 values of 1.2, 149.8 and 22.4 nM for hAChE , hBChE and hGSK-3β, respectively. AChE/GSK-3β-IN-1 penetrates the blood-brain barrier (BBB). AChE/GSK-3β-IN-1 has high kinase selectivity profiles for the CMGC kinase family. AChE/GSK-3β-IN-1 occupies the ATP binding site of DYRK1A. AChE/GSK-3β-IN-1 inhibits ROS expression and reduces oxidative stress. AChE/GSK-3β-IN-1 can be used for Alzheimer’s disease research .
|
-
- HY-N1501R
-
-
- HY-P991046
-
|
|
Amyloid-β
|
Neurological Disease
|
|
Donanemab (Mouse IgG2b) is an anti-amyloid inhibitory antibody with Mouse IgG2b. Donanemab can be used in research about Alzheimer's disease .
|
-
- HY-P5947
-
|
|
HIV
|
Neurological Disease
|
|
Tat-HA-NR2B9 contains a fragment of the cellmembrane transduction domain of HIV-1 Tat, a influenza virus hemagglutinin (HA) epitope-tag, and the C-terminal 9 amino acids of NR2B (NR2B9c). Tat-HA-NR2B9 reduces infarct size and improves neurological functions in ischemia-induced cerebral injury in the rats
|
-
- HY-168522
-
|
|
Integrin
|
Inflammation/Immunology
|
|
αvβ6-IN-2 (compound 20) is a potent and orally active αvβ6 integrin inhibitor with a pIC50 value of 7.8. αvβ6-IN-2 has the potential for the research of idiopathic pulmonary fibrosis .
|
-
- HY-157936
-
|
|
iGluR
|
Neurological Disease
|
|
GluN2B-NMDAR antagonist-2 (compound S-58) is a potent, selective and cross the blood-brain barrier NMDAR-GluN2B antagonist with an IC50 value of 74.01, nM. GluN2B-NMDAR antagonist-2 shows mild cytotoxicity. GluN2B-NMDAR antagonist-2 decreases the cerebral infarction rates and neurologic deficit scores. GluN2B-NMDAR antagonist-2 has the potential for the research of stroke .
|
-
- HY-100370
-
|
|
GABA Receptor
|
Cancer
|
|
MRK-016 is a selective, orally bioavailable inverse agonist of GABAA α5 receptor, with an EC50 of 3 nM for GABAA α5, and Kis of 0.83, 0.85, 0.77?and 1.4?nM for human?GABAA?α1β3γ2, GABAA?α2β3γ2, GABAA?α3β3γ2, and GABAA?α5β3γ2, respectively; MRK-016 also readily penetrates the CNS.
|
-
- HY-157338
-
|
|
ADC Linker
Kinesin
|
Cancer
|
|
NHS-Ala-Ala-Asn-active metabolite is a cleavable antibody-drug conjugate (ADC) linker for synthesis of kinesin spindle protein (KSP)inhibitor .
|
-
- HY-E70470
-
|
|
Cytochrome P450
|
Metabolic Disease
|
|
Human CYP2B6, Low-Reductase, a recombinant CYP2B6, is a member of the CYP enzyme family. CYP2B6 is an anti-obesity enzym, playing a role in the metabolism of numerous xeno- and endobiotic compounds .
|
-
- HY-E70474
-
|
|
Cytochrome P450
|
Metabolic Disease
|
|
Human CYP2B6, High-Reductase, a recombinant CYP2B6, is a member of the CYP enzyme family. CYP2B6 is an anti-obesity enzym, playing a role in the metabolism of numerous xeno- and endobiotic compounds .
|
-
- HY-100740C
-
|
(1α,1'S,4β)-AZD3293; (1α,1'S,4β)-LY3314814
|
Beta-secretase
|
Neurological Disease
|
|
(1α,1'S,4β)-Lanabecestat ((1α,1'S,4β)-AZD3293) a less active enantiomer of Lanabecestat. Lanabecestat is a potent, orally active and blood-brain barrier penetrating BACE1 inhibitor with a Ki of 0.4 nM .
|
-
- HY-111490
-
-
- HY-N2168
-
|
(+)-Pinoresinol 4-O-β-D-glucopyranoside
|
Phosphodiesterase (PDE)
|
Cardiovascular Disease
|
|
Pinoresinol 4-O-β-D-glucopyranoside ((+)-Pinoresinol 4-O-β-D-glucopyranoside) is the major active furofuran type lignans in Fructus Forsythiae. Pinoresinol 4-O-β-D-glucopyranoside shows antioxidant, blood pressure reducing, and cyclic adenosine monophosphate (cAMP) phosphodiesterase inhibitory effects .
|
-
- HY-157491
-
-
- HY-N9372
-
-
- HY-149218
-
|
|
Thyroid Hormone Receptor
|
Metabolic Disease
Inflammation/Immunology
|
|
THR-β agonist 6 is an orally active, selective thyroid hormone receptor β (THR-β) agonist with EC50s of 0.03 μM and 0.22 μM for THR-β and THR-α, respectively. THR-β agonist 6 exhibits an xcellent liver-to-serum ratio of 93:1 in mice. THR-β agonist 6 has the potential for nonalcoholic steatohepatitis (NASH) research .
|
-
- HY-116011
-
|
|
Drug Intermediate
|
Cancer
|
|
N,N'-bis-Cbz-β-Alethine is an active ester used in the synthesis of β-alethine, which induces cell differentiation and has potential anti-tumor applications. β-Alethine is synthesized by removing the carbobenzoxy (CBZ) groups with hydrogen bromide in glacial acetic acid.
|
-
- HY-107509
-
|
|
mGluR
|
Neurological Disease
|
|
LY2389575 hydrochloride is a selective and noncompetitive mGlu3 negative allosteric modulator (NAM), with an IC50 value of 190 nM. LY2389575 hydrochloride induces an increase in Mrc1 levels. LY2389575 hydrochloride also independently amplifies Amyloid beta (Aβ) toxicity and can be used in study of Alzheimer's disease [2] [3].
|
-
- HY-145370
-
|
|
iGluR
|
Neurological Disease
|
|
GluN2B receptor modulator-1 is a selective GluN2B negative allosteric modulator with an IC50 value of 31 nM.
|
-
- HY-116169
-
-
- HY-14773
-
-
- HY-N13704
-
|
|
Others
|
Others
|
|
(19S,23E)-5β,19-Epoxy-19-methoxycucurbita-6,23,25-trien-3β-ol is an active compound.
|
-
- HY-P10320
-
|
Tumstatin (69-88), human
|
PI3K
Akt
|
Cardiovascular Disease
|
|
T3 Peptide is an active fragment of tumstatin. T3 Peptide binds integrin αvβ3/αvβ5, activates the PI3K/Akt/p70S6K signaling pathway, and thus stimulates the proliferation and migration of rat cardiac fibroblasts .
|
-
- HY-137553
-
|
SM934 free base
|
NOD-like Receptor (NLR)
|
Inflammation/Immunology
|
|
β-Aminoarteether (SM934 free base) is an Artemisinin derivative with orally active. β-Aminoarteether can be used for inflammation and autoimmune disease research, such as lupus diseases .
|
-
- HY-119497
-
|
|
Adrenergic Receptor
|
Cardiovascular Disease
Metabolic Disease
|
|
SB251023 is a β3-adrenergic receptor agonist with pEC50 values of 7.14 and 6.91 for the β3a- and β3b-adrenergic receptors, respectively. SB251023 is capable of modulating cyclic AMP levels and extracellular acidification rate (EAR) in cells. It has potential application value in the study of cardiovascular diseases and metabolic-related disorders .
|
-
- HY-103200
-
-
- HY-100672
-
-
- HY-W721582
-
|
|
Glycosidase
|
Others
|
|
β,β-Trehalose is a analog of trehalose. β,β-Trehalose can support the growth of shoot tips of Cuscuta. β,β-Trehalose can be cleaved by nonspecific β-glucosidase .
|
-
- HY-100029B
-
|
|
HBV
|
Infection
|
|
Bay 41-4109 less active enantiomer shows less activity than Bay 41-4109. BAY 41-4109 is a potent inhibitor of human hepatitis B virus (HBV) with an IC50 of 53 nM.
|
-
- HY-B1562C
-
|
(±)-Bopindolol fumarate
|
Adrenergic Receptor
Renin
5-HT Receptor
|
Cardiovascular Disease
Neurological Disease
|
|
Bopindolol ((±)-Bopindolol) fumarate is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol fumarate is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol fumarate has intrinsic sympathomimetic as well as membrane stabilizing actions, inhibits renin secretion, and interacts with 5-HT receptors. Bopindolol fumarate is a proagent of Pindolol (HY-B0982). Bopindolol fumarate can be used for essential and renovascular hypertension research.
|
-
- HY-B1562
-
|
(±)-Bopindolol
|
Adrenergic Receptor
Renin
5-HT Receptor
|
Cardiovascular Disease
Neurological Disease
|
|
Bopindolol ((±)-Bopindolol) is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol has intrinsic sympathomimetic as well as membrane stabilizing actions, inhibits renin secretion, and interacts with 5-HT receptors. Bopindolol is a proagent of Pindolol (HY-B0982). Bopindolol can be used for essential and renovascular hypertension research.
|
-
- HY-N5112
-
|
(Rac)-β,β-Dimethylacrylalkannin; (Rac)-β,β-Dimethylacrylshikonin
|
HIF/HIF Prolyl-Hydroxylase
|
Others
Cancer
|
|
(Rac)-Arnebin 1 ((Rac)-β,β-Dimethylacrylalkannin) is the racemate of β,β-Dimethylacrylalkannin and/or β,β-Dimethylacrylshikonin. β,β-Dimethylacrylalkannin and β,β-Dimethylacrylshikonin are napthoquinones isolated from Arnebia nobilis. β,β-Dimethylacrylshikonin has anti-tumor activity .
|
-
- HY-136679
-
|
|
GSK-3
|
Neurological Disease
Metabolic Disease
|
|
TD114-2 (cmpound 29) is a potent and highly selective inhibitor of glycogen synthase kinase-3β (GSK-3β) (IC50=48 nM). TD114-2 is associated with the hydrogen bond formation of arginine 141 (ARG141) specific to GSK-3β, an amino acid that is often a negatively charged residue in other kinases, which determines the high selectivity of GSK-3β. TD114-2 can be used in the study of diabetes, neurodegenerative diseases and other diseases associated with GSK-3β .
|
-
- HY-19436A
-
|
GW 427353B
|
Adrenergic Receptor
|
Metabolic Disease
Endocrinology
|
|
Solabegron hydrochloride is a selective β3-adrenergic receptor agonist, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR, with an EC50 value of 22 nM . Solabegron hydrochloride (GW 427353) is being developed for the treatment of overactive bladder and irritable bowel syndrome .
|
-
- HY-19690
-
|
KUC-7483 hydrochloride
|
Adrenergic Receptor
|
Metabolic Disease
Endocrinology
|
|
Ritobegron, a prodrug of the active compound, KUC-7322, is a selective β3 -adrenoceptor agonist. Ritobegron decreases intravesical pressure with minimal effects on the cardiovascular system.
|
-
- HY-107670
-
|
DHβE hydrobromide
|
nAChR
|
Neurological Disease
|
|
Dihydro-β-erythroidine (DHβE) hydrobromide is a potent, orally active, and competitive antagonist of neuronal nAChRs. Dihydro-β-erythroidine hydrobromide shows selectivity for α4β4 and α4β2 nAChRs, with IC50s of 0.19 and 0.37 μM, respectively. Antidepressant-like activities [2] [3].
|
-
- HY-P5370
-
|
|
Amyloid-β
|
Others
|
|
Scrambled β-amyloid (1-40) is a biological active peptide. (Aβ (1-40) together with Aβ (1-42) are two major C-terminal variants of the Aβ protein constituting the majority of Aβs. These undergo post-secretory aggregation and deposition in the Alzheimer’s disease brain. This peptide is the scrambled sequence of Abeta 1-40 HY-P0265)
|
-
- HY-P0265F
-
|
|
Amyloid-β
|
Others
|
|
Biotin-Ahx-β-Amyloid (1-40) is a biological active peptide. (Biotin labled HY-P0265)
|
-
- HY-133102
-
|
Lycoraminone
|
GSK-3
|
Neurological Disease
|
|
Dihydronarwedine (Lycoraminone) is the alkaloid. Dihydronarwedine inhibits 39% activity of glycogen synthase kinase-3β (GSK-3β) at a concentration of 10 μM .
|
-
- HY-137854
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Naphthol AS-BI N-acetyl-β-D-glucosaminide acts as a substrate and reacts directly with N-acetyl-β-glucosaminidase enzyme. Naphthol AS-BI N-acetyl-β-D-glucosaminide can detect and localize the active region of N-acetyl-β-glucosaminidase enzyme visually .
|
-
- HY-19436
-
|
GW 427353
|
Adrenergic Receptor
|
Metabolic Disease
Endocrinology
|
|
Solabegron (GW 427353) is a selective β3-adrenergic receptor agonist, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR, with an EC50 value of 22 nM . Solabegron (GW 427353) is being developed for the treatment of overactive bladder and irritable bowel syndrome .
|
-
- HY-A0058
-
|
Retinyl β-D-glucoside
|
Drug Metabolite
|
Metabolic Disease
|
|
Retinyl-β-D-glucoside is a naturally occurring and biologically active metabolites of vitamin A, which are found in fish and mammals.
|
-
- HY-106499
-
-
- HY-117442
-
|
|
Sirtuin
|
Cancer
|
|
A2B57 is a selective inhibitor for SIRT 2 with an IC50 of 6.3 µM .
|
-
- HY-15761
-
|
|
GSK-3
|
Neurological Disease
|
|
AZD2858 is a potent, orally active GSK-3 inhibitor, with IC50s of 0.9 and 5 nM for GSK-3α and GSK-3β, respectively, used in the research of fracture healing.
|
-
- HY-135594
-
|
|
Estrogen Receptor/ERR
|
Metabolic Disease
|
|
4'-Raloxifene-β-D-glucopyranoside, a metabolite of Raloxifene, is a benzothiophene glucuronidated at the 4' postion. 4'-Raloxifene-β-D-glucopyranoside is a selective and orally active estrogen receptor antagonist. 4'-Raloxifene-β-D-glucopyranoside can be used for inhibiting bone loss and resorption, and lowering lipid levels. 4'-Raloxifene-β-D-glucopyranoside, example 5, is extracted from patent US5567820A .
|
-
- HY-135595
-
|
|
Estrogen Receptor/ERR
Drug Metabolite
|
Metabolic Disease
|
|
6-Raloxifene-β-D-glucopyranoside, a derivative of Raloxifene, is a benzothiophene glucuronidated at the 6' postion. 6-Raloxifene-β-D-glucopyranoside is a selective and orally active estrogen receptor antagonist. 6-Raloxifene-β-D-glucopyranoside can be used for inhibiting bone loss and resorption, and lowering lipid levels. 6'-Raloxifene-β-D-glucopyranoside, compound Ia, is extracted from patent US5567820A .
|
-
- HY-113887A
-
|
11β-PGF1β
|
Drug Isomer
|
Endocrinology
|
|
11β-Prostaglandin F1β (11β-PGF1β) is a stereoisomer of PGF1α with inverted C-9 and C-11 hydroxyl groups .
|
-
- HY-N10163
-
|
(+)-1β,10β-Epoxydesacetoxymatricarin
|
Others
|
Others
|
|
1β,10β-Epoxydesacetoxymatricarin is a sesquiterpenoids that can be isolated from Carthamus oxycantha .
|
-
- HY-155534
-
|
|
Endogenous Metabolite
|
Others
|
|
17β-HSD10-IN-1 (compound 9) is an orally active inhibitor of 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10) with blood-brain permeability. 17β-HSD10-IN-1 doesn't result additional effects for mitochondrial off-targets and cytotoxic or neurotoxic effects .
|
-
- HY-13713
-
-
- HY-W009009
-
|
|
GABA Receptor
|
Neurological Disease
|
|
L-838417 is a selective partial agonist at the α2, α3 and α5 subtypes of the GABAA receptor and an antagonist at the α1, with binding Ki values of 0.79 nM, 0.67 nM, 1.67 nM, 267 nM, 2.25 nM and 2183 nM for α1β3γ2, α2β3γ2, α3β3γ2, α4β3γ2, α5β3γ2 and α6β3γ2 .
|
-
- HY-B1562B
-
|
(±)-Bopindolol (malonate)
|
Adrenergic Receptor
Renin
5-HT Receptor
|
Cardiovascular Disease
Neurological Disease
|
|
Bopindolol ((±)-Bopindolol) malonate is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol malonate is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol malonate has intrinsic sympathomimetic as well as membrane stabilizing actions, inhibits renin secretion, and interacts with 5-HT receptors. Bopindolol malonate is a proagent of Pindolol (HY-B0982). Bopindolol malonate can be used for essential and renovascular hypertension research.
|
-
- HY-101393A
-
|
(±)-CGP 12177 hydrochloride
|
Adrenergic Receptor
|
Cardiovascular Disease
|
|
CGP 12177 ((±)-CGP 12177) hydrochloride is a β Adrenergic Receptor Ligand. CGP 12177 hydrochloride is a high affinity antagonist of β1- and β2-AR. CGP 12177 hydrochloride is also shown to interact, with a lower affinity, with the β3-AR and to exhibit a partial agonist activity on rodent and human β3-AR. CGP 12177 hydrochloride exhibits partial agonist properties for α1-AR in rat pulmonary artery .
|
-
- HY-E70393E
-
|
|
Angiotensin Receptor
|
Others
|
|
Human Factor XIIa Beta is the active fragment of coagulation factor XII, that participates in the intrinsic pathway of coagulation, and leads to the formation of blood clots. Human Factor XIIa Beta also participates in the kinin-generating pathway, which leads to the release of bradykinin (vasodilator). Human Factor XIIa Beta stimulates the release of catecholamines, and mediates its cardiovascular effects through a noncholinergic angiotensin-converting enzyme (ACE)-regulated mechanism .
|
-
- HY-107327
-
|
(±)-Carazolol; DL-Carazolol; Suacron
|
Adrenergic Receptor
|
Cardiovascular Disease
|
|
Carazolol is a β1/β2 adrenoceptor antagonist of high potency used in the research of hypertension. Carazolol is also a potent, selective β3-adrenoceptor agonist .
|
-
- HY-123090
-
|
|
11β-HSD
|
Metabolic Disease
|
|
11β-HSD1-IN-12 is a 11β-HSD1 inhibitor (Example 21 in reference patent). 11β-HSD1 regenerates active glucocorticoids from inactive forms and is important in regulating intracellular glucocorticoid concentration. 11β-HSD1-IN-12 can be used in the research of obesity and metabolic syndrome .
|
-
- HY-N9452
-
|
|
Others
|
Others
|
|
Capsaicin β-D-glucopyranoside is a glucoside converted by Capsaicin. Capsaicin is the active ingredient of chili peppers and gives them the characteristic pungent flavor [2].
|
-
- HY-111479
-
-
- HY-103207
-
-
- HY-14156
-
|
|
11β-HSD
|
Metabolic Disease
|
|
11β-HSD1-IN-15 is an inhibitor of 11β-hydroxysteroid dehydrogenase type I (11β-HSD1). 11β-HSD1-IN-15 blocks the conversion of corticosterone to cortisol by binding to the active site of the 11β-HSD1 enzyme. 11β-HSD1-IN-15 can be used to investigate the role of 11β-HSD1 enzymes IN the development of metabolic syndrome, obesity, cognitive decline and type 2 diabetes .
|
-
- HY-N10750
-
|
|
Others
|
Others
|
|
1α, 2α-Diacetoxy-8β-isobutanoyloxy-9α-benzoyloxy-15-β-(β-furancarbonyloxy)-4β, 6β-dihydroxy-β-dihydroagarofuran (compound 7) is an eudesmane-type sesquiterpenoid that can be founfd in the the root bark of Pseudolarix kaempferi .
|
-
- HY-168521
-
|
|
Integrin
|
Inflammation/Immunology
|
|
αvβ6-IN-1 (compound 28) is a potent and orally active αvβ6 integrin inhibitor with a pIC50 value of 8.1. αvβ6-IN-1 has the potential for the research of idiopathic pulmonary fibrosis .
|
-
- HY-139137
-
|
AGGC
|
DNA Methyltransferase
Integrin
|
Cancer
|
|
N-Acetyl-S-geranylgeranyl-L-cysteine is a Methyltransferase inhibitor. N-Acetyl-S-geranylgeranyl-L-cysteine inhibits beta 2 integrin-induced actin polymerization with an IC50 of 45 nM .
|
-
- HY-E70488
-
|
|
Cytochrome P450
|
Metabolic Disease
|
|
Human CYP2B6, High-Reductase+b5, a recombinant CYP2B6, is a member of the CYP enzyme family. CYP2B6 is an anti-obesity enzym, playing a role in the metabolism of numerous xeno- and endobiotic compounds .
|
-
- HY-E70504
-
|
|
Cytochrome P450
|
Metabolic Disease
|
|
Human CYP2B6, Low-Reductase+b5, a recombinant CYP2B6, is a member of the CYP enzyme family. CYP2B6 is an anti-obesity enzym, playing a role in the metabolism of numerous xeno- and endobiotic compounds .
|
-
- HY-139314
-
|
|
Adenosine Receptor
|
Metabolic Disease
|
A2B receptor antagonist 2 (compound 18) is an adenosine receptor A2B antagonist, with Ki values of 2.30 μM, 6.8 μM and 3.44 μM for rA1, rA2A and hA2B, respectively .
|
-
- HY-144644A
-
-
- HY-N0892
-
-
- HY-144644
-
-
- HY-16673
-
|
|
GPR119
|
Metabolic Disease
|
|
PSN632408, a selective, orally active GPR119 agonist, shows similar potency to OEA at both recombinant mouse and human GPR119 receptors (EC50=5.6 and 7.9 uM, respectively). PSN632408 can stimulate β-cell replication and improve islet graft function. PSN632408 has the potential for the research of obesity and related metabolic disorders [2].
|
-
- HY-146776S
-
-
- HY-107324
-
|
(-)-β-Elemene; Levo-β-elemene
|
Apoptosis
|
Cancer
|
|
β-Elemene ((-)-β-Elemene; Levo-β-elemene) is isolated from natural plant Curcuma aromatica with an antitumor activity. β-Elemene can induce cell apoptosis.
|
-
- HY-130502
-
|
Cholesterol 5beta,6beta-epoxide
|
Biochemical Assay Reagents
|
Others
|
|
5β,6β-epoxycholestanol is an oxidative metabolite of cholesterol formed by free-radical and non-radical oxidation of cholesterol at the 5,6 double bond. Induces lactate dehydrogenase (LDH) release and apoptosis in macrophage-differentiated U937 cells. Cholesterol 5beta,6beta-epoxide has been found in human fatty streaks and advanced atherosclerotic lesions, but not in normal aortic tissue [2] [3].
|
-
- HY-N2513
-
|
|
Lipoxygenase
DNA/RNA Synthesis
|
Cancer
|
|
β-Boswellic acid is isolated from the gum resin of Boswellia serrata with anticancer, antioxidant activity, anti-inflammatory activity and anti-arthritic pain.β-Boswellic acid is an orally active nonreducing-type inhibitor of the 5-lipoxygenase (5-LO) product formation either interacting directly with the 5-LO or blocking its translocation. β-Boswellic acid inhibits the synthesis of DNA, RNA and protein in human leukemia HL-60 cells with IC50 values ranging from 0.6 to 7.1 μM. β-Boswellic acid is promising for research of diabetes, inflammatory and arthritic diseases [2] [3] .
|
-
- HY-N10587
-
|
|
Others
|
Inflammation/Immunology
|
|
Catechin 7-O-beta-D-glucopyranoside is an orally active natural product found in Ulmus davidiana and Paeonia obovata. Catechin 7-O-β-D-glucopyranoside shows antioxidant and anti-inflammatory activities, and attenuates mitochondrial dysfunction. Catechin 7-O-beta-D-glucopyranoside can be used in intestinal inflammatory disease research [2] [3].
|
-
- HY-105272A
-
|
R 72063 hydrochloride
|
GABA Receptor
|
Neurological Disease
|
|
Loreclezole hydrochloride, an antiepileptic compound, is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors [2].
|
-
- HY-105272
-
|
R 72063
|
GABA Receptor
|
Neurological Disease
|
|
Loreclezole, an antiepileptic compound, is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors [2].
|
-
- HY-N6605
-
|
Trifolin
|
Apoptosis
|
Cardiovascular Disease
Cancer
|
|
Kaempferol 3-O-β-D-galactopyranoside (Trifolin) is an orally active flavonoid derivative that can be found in the aerial parts of Consolida oliverana. Kaempferol 3-O-β-D-galactopyranoside exhibits antitumor and cardioprotective effects [2] [3].
|
-
- HY-163318
-
-
- HY-150600
-
|
|
Virus Protease
Flavivirus
|
Infection
|
|
NS2B/NS3-IN-7 (compound 26) is a highly potent Zika virus NS2B-NS3 protease inhibitor with a Ki value of 2.33 nM. NS2B/NS3-IN-7 can reduce amounts of ZIKV-infected cells .
|
-
- HY-B0203A
-
|
R 065824 hydrochloride
|
Adrenergic Receptor
|
Cardiovascular Disease
Endocrinology
Cancer
|
|
Nebivolol (R 065824) hydrochloride is an orally active beta receptor blocker and has the high beta(1)-receptor affinity.Nebivolol hydrochloride has direct vasodilator properties and adrenergic blocking characteristics. Nebivolol hydrochloride can be used for the research of kinds of diseases such as hypertension, coronary artery disease, congestive heart failure and ischemic heart disease [2].
|
-
- HY-B0203
-
|
R 065824
|
Adrenergic Receptor
|
Cardiovascular Disease
Endocrinology
Cancer
|
|
Nebivolol (R 065824) is an orally active beta receptor blocker and has the high beta(1)-receptor affinity. Nebivolol has direct vasodilator properties and adrenergic blocking characteristics. Nebivolol can be used for the research of kinds of diseases such as hypertension, coronary artery disease, congestive heart failure and ischemic heart disease [2].
|
-
- HY-19401
-
-
- HY-W250154
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
β-Nicotinamide adenine dinucleotide reduced dipotassium is an orally active reduced coenzyme. β-Nicotinamide adenine dinucleotide reduced dipotassium is a donor of ADP-ribose units in ADP-ribosylaton reactions and a precursor of cyclic ADP-ribose. β-Nicotinamide adenine dinucleotide reduced dipotassium plays a role as a regenerative electron donor in cellular energy metabolism, including glycolysis, β-oxidation and the tricarboxylic acid (TCA) cycle .
|
-
- HY-N2168R
-
|
|
Phosphodiesterase (PDE)
|
Cardiovascular Disease
|
|
Pinoresinol 4-O-β-D-glucopyranoside (Standard) is the analytical standard of Pinoresinol 4-O-β-D-glucopyranoside. This product is intended for research and analytical applications. Pinoresinol 4-O-β-D-glucopyranoside ((+)-Pinoresinol 4-O-β-D-glucopyranoside) is the major active furofuran type lignans in Fructus Forsythiae. Pinoresinol 4-O-β-D-glucopyranoside shows antioxidant, blood pressure reducing, and cyclic adenosine monophosphate (cAMP) phosphodiesterase inhibitory effects .
|
-
- HY-107489
-
|
|
GABA Receptor
|
Neurological Disease
|
|
RO 4938581 is a potent and selective GABAA α5 inverse agonist, with a Ki of 4.6 nM for GABAA α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (Ki, 174, 185, 80 nM, respectively); RO 4938581 is used in the research of cognitive dysfunction.
|
-
- HY-144612
-
|
|
Flavivirus
Dengue Virus
Virus Protease
|
Infection
|
|
NS2B/NS3-IN-2 is a potent dengue virus (DENV) NS2B/NS3 covalent inhibitor with an IC50 of 6.0 nM and Ki of 0.66 µM. NS2B/NS3-IN-2 shows no cytotoxicity and markedly increases the cell survival rate .
|
-
- HY-N9145
-
|
|
Others
|
Others
|
|
1beta,10beta-Epoxydehydroleucodin is a Sesquiterpenoids product that can be isolated from the roots of Scorzonera latifolia .
|
-
- HY-147295
-
|
BTH 1677; Imprime PGG
|
Toll-like Receptor (TLR)
|
Inflammation/Immunology
Cancer
|
|
Odetiglucan is a novel β-glucan that is a potent immunostimulant and a Dectin-1 (CLEC7A) agonist. Odetiglucan activates innate immune effector cells and triggers a coordinated anti-cancer immune response [2].
|
-
- HY-P5796
-
|
|
Calcium Channel
|
Neurological Disease
|
|
FS-2 is a potent and specific L-type CaV channel inhibitor. FS-2 inhibits high K + or glucose induced L-type Ca 2+ influx in RIN beta cells .
|
-
- HY-137912
-
|
|
Drug Metabolite
|
Endocrinology
Cancer
|
|
trans-Resveratrol-3-O-β-D-Glucuronide is an active metabolite of trans-resveratrol. trans-Resveratrol-3-O-β-D-Glucuronide reduces the proliferation of several intestinal cancer cell line. trans-Resveratrol-3-O-β-D-Glucuronide increases pyruvate production in livers [2] [3].
|
-
- HY-B0573A
-
|
|
Adrenergic Receptor
|
Cardiovascular Disease
Inflammation/Immunology
|
|
(S)-(-)-Propranolol hydrochloride is a β-adrenergic receptor antagonist with log Kd values of -8.16, -9.08, and -6.93 for β1, β2, and β3, respectively. (S)-(-)-Propranolol hydrochloride the active enantiomer of propranolol and can be s used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy [2].
|
-
- HY-169330
-
|
|
Drug Metabolite
|
Neurological Disease
Metabolic Disease
|
|
3β,5α,6β-Trihydroxycholanic acid is a metabolite of 3β,5α,6β-Trihydroxycholestane (HY-W010934). 3β,5α,6β-Trihydroxycholanic acid can be used in research related to neurodegenerative diseases associated with lysosomal dysfunction .
|
-
- HY-100635
-
-
- HY-144740
-
|
|
Virus Protease
|
Infection
|
|
NS2B/NS3-IN-5 (Compound 25b) is an allosteric DENV2 and ZIKV NS2B/NS3 protease inhibitor with IC50 values of 0.67 µM and 4.38 µM against ZIKV and DENV2 NS2B/NS3 proteases, respectively .
|
-
- HY-144736
-
|
|
Virus Protease
|
Infection
|
|
NS2B/NS3-IN-4 (Compound 34e) is an allosteric DENV2 and ZIKV NS2B/NS3 protease inhibitor with IC50 values of 0.69 µM and 1.04 µM against DENV2 and ZIKV NS2B/NS3 proteases, respectively .
|
-
- HY-U00321
-
-
- HY-119868
-
|
Butoxamin
|
Adrenergic Receptor
|
Metabolic Disease
|
|
Butaxamine (Butoxamin) is a potent, selective and orally active β2-adrenoceptor antagonist. Butaxamine shows antiosteoporotic activity .
|
-
- HY-126123
-
|
|
iGluR
Potassium Channel
|
Neurological Disease
|
|
NR2B-selective NMDA receptor antagonist 1 (compound 29) is a potent antagonist of NR1/NR2B receptors, with IC50s of 0.05 μM, 0.73 μM, 2.4 μM to NR1/NR2B NMDA receptor, hERG, α1-AdR, respectivity. NR2B-selective NMDA receptor antagonist 1 exhibites efficient permeability across the blood–brain barrier .
|
-
- HY-148804
-
|
APD418
|
Adrenergic Receptor
|
Endocrinology
|
|
Vemtoberant is an β3 Adrenergic Receptor antagonist. Vemtoberant can be used for research of β3 adrenergic receptor-mediated disorder, such as, heart failure [2].
|
-
- HY-148804A
-
|
APD418 mesylate
|
Adrenergic Receptor
|
Endocrinology
|
|
Vemtoberant mesylate is an β3 Adrenergic Receptor antagonist. Vemtoberant mesylate can be used for research of β3 adrenergic receptor-mediated disorder, such as, heart failure [2].
|
-
- HY-W154341
-
|
|
Biochemical Assay Reagents
|
Others
|
|
3-Indolyl-β-D-glucuronide cyclohexanamine is the glucose component of X-Gluc staining buffer. 3-Indolyl-β-D-glucuronide cyclohexanamine can be used to detect gene expression. The active ingredient of the stain, β-Glucuronidase (GUS), reacts with the enzyme, causing the target gene to appear blue-purple in tissues or cells, so that the expression level and tissue distribution of the gene can be visually observed .
|
-
- HY-14872
-
|
NP031112
|
GSK-3
|
Neurological Disease
|
|
Tideglusib (NP031112) is an irreversible GSK-3 inhibitor with IC50s of 5 nM and 60 nM for GSK-3β WT (1 h preincubation) and GSK-3β C199A (1 h preincubation), respectively.
|
-
- HY-N9738
-
|
|
Endogenous Metabolite
|
Others
|
|
14β,16β-Dihydroxy-3β-(β-D-glucopyranosyloxy)-5α-bufa-20,22-dienolide (compound 10) is a butadiene lactone that can be used in related research in the field of life sciences.
|
-
- HY-100672B
-
|
|
Adrenergic Receptor
|
Cardiovascular Disease
Metabolic Disease
|
|
(2R)-SR59230A is the isomer of SR59230A (HY-100672), and can be used as an experimental control. SR59230A is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively [2].
|
-
- HY-N5112B
-
|
Isoarnebin I
|
HIF/HIF Prolyl-Hydroxylase
Apoptosis
Notch
NO Synthase
Bcl-2 Family
|
Cancer
|
|
β,β-Dimethylacrylshikonin (Isoarnebin I) is a naphthoquinone derivative that can be isolated from Lithospermum erythrorhizon Sieb. et Zucc. β,β-Dimethylacrylshikonin promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway. β,β-Dimethylacrylshikonin inhibits Notch-1 activation. β,β-Dimethylacrylshikonin inhibtis tumor cell proliferation, induces tumor cell apoptosis, and inhibits tumor growth [2] [3] .
|
-
- HY-N9040
-
|
|
Others
|
Others
|
|
6β-Angeloyloxy-1β,10β-epoxy-9-oxo-furaneremophilane is a Sesquiterpenoids product that can be isolated from the herbs of Ligularia songarica. .
|
-
- HY-107327R
-
|
|
Adrenergic Receptor
|
Cardiovascular Disease
|
|
Carazolol (Standard) is the analytical standard of Carazolol. This product is intended for research and analytical applications. Carazolol is a β1/β2 adrenoceptor antagonist of high potency used in the research of hypertension. Carazolol is also a potent, selective β3-adrenoceptor agonist .
|
-
- HY-116030
-
|
|
Integrin
|
Metabolic Disease
|
|
JNJ-26076713 is a potent and orally active alpha V integrin antagonist with IC50 values of 2.3 nM and 6.3 nM for alpha(V)beta(3) and alpha(V)beta(5), respectively. JNJ-26076713 inhibits retinal neovascularization .
|
-
- HY-14773R
-
-
- HY-W015084A
-
|
β-Lonone
|
Apoptosis
|
Cancer
|
|
(E)-β-Ionone is the isomer of β-Ionone (HY-W015084). β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. β-Ionone has anti-cancer activity .
|
-
- HY-103211
-
L748337
1 Publications Verification
|
Adrenergic Receptor
|
Cardiovascular Disease
Metabolic Disease
Cancer
|
|
L748337 is a potent β3-adrenergic receptor antagonist and displays selectivity over β1 and β2 receptors. The Ki values of L748337 for β3-, β2- and β1-adrenoceptors are 4.0 nM, 204 nM and 390 nM, respectively . L748337 couples predominantly to Gi to activate MAPK signaling and increases phosphorylation of Erk1/2 with pEC50 value of 11.6 [2]. L748337 can be used for the research of cancer, nonalcoholic fatty liver disease (NAFLD), and cardiovascular related diseases [2] [3].
|
-
- HY-101325
-
-
- HY-14773S
-
-
- HY-169340
-
|
|
Adrenergic Receptor
|
Inflammation/Immunology
|
|
SAR-150640, a selective β3-adrenoceptor agonist, prevents the increase in MMP activity and production observed after LPS stimulation or in cases of chorioamnionitis .
|
-
- HY-P1187
-
|
|
Integrin
|
Cancer
|
HSDVHK-NH2 is an antagonist of the integrin αvβ3-vitronectin interaction, with an IC50 of 1.74 pg/mL (2.414 pM) [2].
|
-
- HY-19401A
-
-
- HY-101461
-
|
Methyl-beta-cyclodextrin
|
Biochemical Assay Reagents
|
Cancer
|
|
Methyl-β-cyclodextrin (Methyl-beta-cyclodextrin) is a cyclic heptasaccharide used to deliver hydrophobic agents based on its property of solubilizing non-polar substances. Methyl-β-cyclodextrin is also extensively used as a cholesterol-depleting reagent . Methyl-β-cyclodextrin strongly reduces clathrin-dependent endocytosis [2]. Methyl-β-cyclodextrin blocks cell migrasome formation [3].
|
-
- HY-N7170
-
|
|
Glycosidase
|
Metabolic Disease
|
|
(-)-6β-Hydroxy-5β,8β,9β,10α-cleroda-3,13-dien-16,15-olid-18-oic acid (compound 4) is a α-Glucosidase inhibitor with an IC50 value of 577.7 µM .
|
-
- HY-W010934S
-
-
- HY-W113965
-
|
Octaacetyl-β-maltose; β-D-Maltopyranose octaacetate
|
Biochemical Assay Reagents
|
Others
|
|
β-D-Maltose octaacetate (Octaacetyl-β-maltose; β-D-Maltopyranose octaacetate) is a synthetic sugar compound.
|
-
- HY-141468
-
|
β-CNA dihydrochloride
|
Opioid Receptor
|
Neurological Disease
|
|
β-Chlornaltrexamine dihydrochloride (β-CNA dihydrochloride) is a potent long-term opioid receptor blocker. β-Chlornaltrexamine dihydrochloride can effectively block the inhibitory effect of κ opioid receptor agonists on dopamine release. β-Chlornaltrexamine dihydrochloride can be used to study the mechanism of pain perception .
|
-
- HY-10590
-
-
- HY-124499
-
|
|
Integrin
|
Cardiovascular Disease
|
|
RUC-1 (Compound 1) is an inhibitor for αIIbβ3 integrin. RUC-1 inhibits fibrin deposition and platelet aggregation in hybrid hαIIb/mβ3 receptors expressing mice. RUC-1 exhibits antithrombotic effect in hαIIb/mβ3 receptor expressing mice .
|
-
- HY-10133
-
|
|
Beta-secretase
|
Neurological Disease
|
|
β-Secretase Inhibitor IV is a potent, cell-active BACE-1 inhibitor with IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively.
|
-
- HY-120643
-
|
|
11β-HSD
|
Metabolic Disease
|
|
BMS-823778 hydrochloride is a potent, selective and orally active 11β-HSD1 inhibitor with an IC50 of 2.3 nM against human 11β-HSD1 .
|
-
- HY-N1615
-
|
|
Others
|
Others
|
|
1beta-Hydroxy-beta-eudesmol is a Sesquiterpenoids product that can be isolated from the herbs of Cymbopogon proximus STAPF. .
|
-
- HY-137472
-
|
|
GSK-3
|
Neurological Disease
|
|
SAR502250 is a potent, selective, ATP competitive, orally active and brain-penetrant inhibitor of GSK3, with an IC50 of 12 nM for human GSK-3β. SAR502250 displays antidepressant-like activity. SAR502250 can be used for the research of Alzheimer’s disease (AD) [2].
|
-
- HY-P1187A
-
|
|
Integrin
|
Cancer
|
HSDVHK-NH2 TFA is an antagonist of the integrin αvβ3-vitronectin interaction, with an IC50 of 1.74 pg/mL (2.414 pM) [2].
|
-
- HY-RS14965
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
TRABD2B Human Pre-designed siRNA Set A contains three designed siRNAs for TRABD2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
TRABD2B Human Pre-designed siRNA Set A
TRABD2B Human Pre-designed siRNA Set A
- HY-RS10843
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
POLR2B Human Pre-designed siRNA Set A contains three designed siRNAs for POLR2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
POLR2B Human Pre-designed siRNA Set A
POLR2B Human Pre-designed siRNA Set A
- HY-RS05894
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
GTF2B Human Pre-designed siRNA Set A contains three designed siRNAs for GTF2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
GTF2B Human Pre-designed siRNA Set A
GTF2B Human Pre-designed siRNA Set A
- HY-RS07283
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
KIF2B Human Pre-designed siRNA Set A contains three designed siRNAs for KIF2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
KIF2B Human Pre-designed siRNA Set A
KIF2B Human Pre-designed siRNA Set A
- HY-RS14962
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
TRA2B Human Pre-designed siRNA Set A contains three designed siRNAs for TRA2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
TRA2B Human Pre-designed siRNA Set A
TRA2B Human Pre-designed siRNA Set A
- HY-RS12026
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
RNASEH2B Human Pre-designed siRNA Set A contains three designed siRNAs for RNASEH2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
RNASEH2B Human Pre-designed siRNA Set A
RNASEH2B Human Pre-designed siRNA Set A
- HY-RS00249
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
Acvr2b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Acvr2b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
Acvr2b Mouse Pre-designed siRNA Set A
Acvr2b Mouse Pre-designed siRNA Set A
- HY-RS11115
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
PRKAR2B Human Pre-designed siRNA Set A contains three designed siRNAs for PRKAR2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
PRKAR2B Human Pre-designed siRNA Set A
PRKAR2B Human Pre-designed siRNA Set A
- HY-RS08978
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
MZT2B Human Pre-designed siRNA Set A contains three designed siRNAs for MZT2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
MZT2B Human Pre-designed siRNA Set A
MZT2B Human Pre-designed siRNA Set A
- HY-RS07210
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
KDM2B Human Pre-designed siRNA Set A contains three designed siRNAs for KDM2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
KDM2B Human Pre-designed siRNA Set A
KDM2B Human Pre-designed siRNA Set A
- HY-RS09775
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
OLFML2B Human Pre-designed siRNA Set A contains three designed siRNAs for OLFML2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
OLFML2B Human Pre-designed siRNA Set A
OLFML2B Human Pre-designed siRNA Set A
- HY-RS01146
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
ATG2B Human Pre-designed siRNA Set A contains three designed siRNAs for ATG2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
ATG2B Human Pre-designed siRNA Set A
ATG2B Human Pre-designed siRNA Set A
- HY-RS04575
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
EVI2B Human Pre-designed siRNA Set A contains three designed siRNAs for EVI2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
EVI2B Human Pre-designed siRNA Set A
EVI2B Human Pre-designed siRNA Set A
- HY-RS06984
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
ITM2B Human Pre-designed siRNA Set A contains three designed siRNAs for ITM2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
ITM2B Human Pre-designed siRNA Set A
ITM2B Human Pre-designed siRNA Set A
- HY-RS08168
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
MAT2B Human Pre-designed siRNA Set A contains three designed siRNAs for MAT2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
MAT2B Human Pre-designed siRNA Set A
MAT2B Human Pre-designed siRNA Set A
- HY-RS00397
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
ADORA2B Human Pre-designed siRNA Set A contains three designed siRNAs for ADORA2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
ADORA2B Human Pre-designed siRNA Set A
ADORA2B Human Pre-designed siRNA Set A
- HY-RS09974
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
PAGE2B Human Pre-designed siRNA Set A contains three designed siRNAs for PAGE2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
PAGE2B Human Pre-designed siRNA Set A
PAGE2B Human Pre-designed siRNA Set A
- HY-RS11266
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
PRXL2B Human Pre-designed siRNA Set A contains three designed siRNAs for PRXL2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
PRXL2B Human Pre-designed siRNA Set A
PRXL2B Human Pre-designed siRNA Set A
- HY-RS01857
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
CAMK2B Human Pre-designed siRNA Set A contains three designed siRNAs for CAMK2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
CAMK2B Human Pre-designed siRNA Set A
CAMK2B Human Pre-designed siRNA Set A
- HY-RS02416
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
CDKN2B Human Pre-designed siRNA Set A contains three designed siRNAs for CDKN2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
CDKN2B Human Pre-designed siRNA Set A
CDKN2B Human Pre-designed siRNA Set A
- HY-RS14897
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
TOP2B Human Pre-designed siRNA Set A contains three designed siRNAs for TOP2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
TOP2B Human Pre-designed siRNA Set A
TOP2B Human Pre-designed siRNA Set A
- HY-RS12287
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
RRM2B Human Pre-designed siRNA Set A contains three designed siRNAs for RRM2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
RRM2B Human Pre-designed siRNA Set A
RRM2B Human Pre-designed siRNA Set A
- HY-RS15833
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
WNT2B Human Pre-designed siRNA Set A contains three designed siRNAs for WNT2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
WNT2B Human Pre-designed siRNA Set A
WNT2B Human Pre-designed siRNA Set A
- HY-RS08392
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
MFSD2B Human Pre-designed siRNA Set A contains three designed siRNAs for MFSD2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
MFSD2B Human Pre-designed siRNA Set A
MFSD2B Human Pre-designed siRNA Set A
- HY-RS15715
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
VSTM2B Human Pre-designed siRNA Set A contains three designed siRNAs for VSTM2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
VSTM2B Human Pre-designed siRNA Set A
VSTM2B Human Pre-designed siRNA Set A
- HY-RS08310
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
MEF2B Human Pre-designed siRNA Set A contains three designed siRNAs for MEF2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
MEF2B Human Pre-designed siRNA Set A
MEF2B Human Pre-designed siRNA Set A
- HY-RS01380
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
BAZ2B Human Pre-designed siRNA Set A contains three designed siRNAs for BAZ2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
BAZ2B Human Pre-designed siRNA Set A
BAZ2B Human Pre-designed siRNA Set A
- HY-RS03253
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
CSNK2B Human Pre-designed siRNA Set A contains three designed siRNAs for CSNK2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
CSNK2B Human Pre-designed siRNA Set A
CSNK2B Human Pre-designed siRNA Set A
- HY-RS11402
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
PTK2B Human Pre-designed siRNA Set A contains three designed siRNAs for PTK2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
PTK2B Human Pre-designed siRNA Set A
PTK2B Human Pre-designed siRNA Set A
- HY-RS11542
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
RAB2B Human Pre-designed siRNA Set A contains three designed siRNAs for RAB2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
RAB2B Human Pre-designed siRNA Set A
RAB2B Human Pre-designed siRNA Set A
- HY-RS14055
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
SV2B Human Pre-designed siRNA Set A contains three designed siRNAs for SV2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
SV2B Human Pre-designed siRNA Set A
SV2B Human Pre-designed siRNA Set A
- HY-RS07079
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
KAT2B Rat Pre-designed siRNA Set A contains three designed siRNAs for KAT2B gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
KAT2B Rat Pre-designed siRNA Set A
KAT2B Rat Pre-designed siRNA Set A
- HY-RS07078
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
Kat2b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kat2b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
Kat2b Mouse Pre-designed siRNA Set A
Kat2b Mouse Pre-designed siRNA Set A
- HY-RS00398
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
Adora2b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Adora2b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
Adora2b Mouse Pre-designed siRNA Set A
Adora2b Mouse Pre-designed siRNA Set A
- HY-RS00412
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
ADRA2B Human Pre-designed siRNA Set A contains three designed siRNAs for ADRA2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
ADRA2B Human Pre-designed siRNA Set A
ADRA2B Human Pre-designed siRNA Set A
- HY-RS05297
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
GATAD2B Human Pre-designed siRNA Set A contains three designed siRNAs for GATAD2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
GATAD2B Human Pre-designed siRNA Set A
GATAD2B Human Pre-designed siRNA Set A
- HY-RS03773
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
DIP2B Human Pre-designed siRNA Set A contains three designed siRNAs for DIP2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
DIP2B Human Pre-designed siRNA Set A
DIP2B Human Pre-designed siRNA Set A
- HY-RS15253
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
TUBB2B Human Pre-designed siRNA Set A contains three designed siRNAs for TUBB2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
TUBB2B Human Pre-designed siRNA Set A
TUBB2B Human Pre-designed siRNA Set A
- HY-RS08363
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
METTL2B Human Pre-designed siRNA Set A contains three designed siRNAs for METTL2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
METTL2B Human Pre-designed siRNA Set A
METTL2B Human Pre-designed siRNA Set A
- HY-RS12532
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
SCN2B Human Pre-designed siRNA Set A contains three designed siRNAs for SCN2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
SCN2B Human Pre-designed siRNA Set A
SCN2B Human Pre-designed siRNA Set A
- HY-RS00399
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
Adora2b Rat Pre-designed siRNA Set A contains three designed siRNAs for Adora2b gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
Adora2b Rat Pre-designed siRNA Set A
Adora2b Rat Pre-designed siRNA Set A
- HY-RS15092
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
TRMT2B Human Pre-designed siRNA Set A contains three designed siRNAs for TRMT2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
TRMT2B Human Pre-designed siRNA Set A
TRMT2B Human Pre-designed siRNA Set A
- HY-RS15337
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
UBE2B Human Pre-designed siRNA Set A contains three designed siRNAs for UBE2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
UBE2B Human Pre-designed siRNA Set A
UBE2B Human Pre-designed siRNA Set A
- HY-RS13705
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
SPPL2B Human Pre-designed siRNA Set A contains three designed siRNAs for SPPL2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
SPPL2B Human Pre-designed siRNA Set A
SPPL2B Human Pre-designed siRNA Set A
- HY-RS00250
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
Acvr2b Rat Pre-designed siRNA Set A contains three designed siRNAs for Acvr2b gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
Acvr2b Rat Pre-designed siRNA Set A
Acvr2b Rat Pre-designed siRNA Set A
- HY-RS07402
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
KMT2B Human Pre-designed siRNA Set A contains three designed siRNAs for KMT2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
KMT2B Human Pre-designed siRNA Set A
KMT2B Human Pre-designed siRNA Set A
- HY-RS03920
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
DOC2B Human Pre-designed siRNA Set A contains three designed siRNAs for DOC2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
DOC2B Human Pre-designed siRNA Set A
DOC2B Human Pre-designed siRNA Set A
- HY-RS00674
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
AMY2B Human Pre-designed siRNA Set A contains three designed siRNAs for AMY2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
AMY2B Human Pre-designed siRNA Set A
AMY2B Human Pre-designed siRNA Set A
- HY-RS11658
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
RAP2B Human Pre-designed siRNA Set A contains three designed siRNAs for RAP2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
RAP2B Human Pre-designed siRNA Set A
RAP2B Human Pre-designed siRNA Set A
- HY-RS06949
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
ITGA2B Human Pre-designed siRNA Set A contains three designed siRNAs for ITGA2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
ITGA2B Human Pre-designed siRNA Set A
ITGA2B Human Pre-designed siRNA Set A
- HY-RS04829
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
FCGR2B Human Pre-designed siRNA Set A contains three designed siRNAs for FCGR2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
FCGR2B Human Pre-designed siRNA Set A
FCGR2B Human Pre-designed siRNA Set A
- HY-RS02641
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
CHMP2B Human Pre-designed siRNA Set A contains three designed siRNAs for CHMP2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
CHMP2B Human Pre-designed siRNA Set A
CHMP2B Human Pre-designed siRNA Set A
- HY-RS14155
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
TADA2B Human Pre-designed siRNA Set A contains three designed siRNAs for TADA2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
TADA2B Human Pre-designed siRNA Set A
TADA2B Human Pre-designed siRNA Set A
- HY-RS07077
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
KAT2B Human Pre-designed siRNA Set A contains three designed siRNAs for KAT2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
KAT2B Human Pre-designed siRNA Set A
KAT2B Human Pre-designed siRNA Set A
- HY-RS10452
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
PHOX2B Human Pre-designed siRNA Set A contains three designed siRNAs for PHOX2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
PHOX2B Human Pre-designed siRNA Set A
PHOX2B Human Pre-designed siRNA Set A
- HY-RS14409
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
TFAP2B Human Pre-designed siRNA Set A contains three designed siRNAs for TFAP2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
TFAP2B Human Pre-designed siRNA Set A
TFAP2B Human Pre-designed siRNA Set A
- HY-RS00248
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
ACVR2B Human Pre-designed siRNA Set A contains three designed siRNAs for ACVR2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
ACVR2B Human Pre-designed siRNA Set A
ACVR2B Human Pre-designed siRNA Set A
- HY-RS01573
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
BOLA2B Human Pre-designed siRNA Set A contains three designed siRNAs for BOLA2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
BOLA2B Human Pre-designed siRNA Set A
BOLA2B Human Pre-designed siRNA Set A
- HY-RS11237
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
PRRC2B Human Pre-designed siRNA Set A contains three designed siRNAs for PRRC2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
PRRC2B Human Pre-designed siRNA Set A
PRRC2B Human Pre-designed siRNA Set A
- HY-RS05917
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
GUCA2B Human Pre-designed siRNA Set A contains three designed siRNAs for GUCA2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
GUCA2B Human Pre-designed siRNA Set A
GUCA2B Human Pre-designed siRNA Set A
- HY-RS06468
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
HTR2B Human Pre-designed siRNA Set A contains three designed siRNAs for HTR2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
HTR2B Human Pre-designed siRNA Set A
HTR2B Human Pre-designed siRNA Set A
- HY-RS01120
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
ATAD2B Human Pre-designed siRNA Set A contains three designed siRNAs for ATAD2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
ATAD2B Human Pre-designed siRNA Set A
ATAD2B Human Pre-designed siRNA Set A
- HY-144742
-
|
|
Virus Protease
|
Infection
|
|
NS2B/NS3-IN-6 (Compound 1a) is an allosteric DENV and ZIKV NS2B/NS3 protease inhibitor with IC50 values of 2.23 µM and 25.2 µM against ZIKV and DENV proteases, respectively .
|
-
- HY-15102
-
MK-0429
4 Publications Verification
L-000845704
|
Integrin
|
Inflammation/Immunology
Cancer
|
|
MK-0429 (L-000845704) is an orally active, potent, selective and nonpeptide pan-integrin antagonist with IC50 values of 1.6 nM, 2.8 nM, 0.1 nM, 0.7 nM, 0.5 nM and 12.2 nM for αvβ1, αvβ3, αvβ5, αvβ6, αvβ8 and α5β1, respectively [2] [3].
|
-
- HY-161701
-
|
|
Androgen Receptor
|
Cancer
|
|
(3β,4β,17β)-17-(2-Pyridinylmethyl)androst-5-ene-3,4,17-triol is an androstane derivative with anticancer activity .
|
-
- HY-153256
-
|
|
Prostaglandin Receptor
|
Metabolic Disease
|
|
EP3 antagonist 4 (Compound 28) is an EP3 antagonist, with a Ki value of 2 nM for hEP. EP3 antagonist 4 shows low in vivo clearance, high oral AUC, and good bioavailability in the rat full PK studies. EP3 antagonist 4 can be used for research of beta cell dysfunction in diabetes .
|
-
- HY-N4180
-
|
|
Atg8/LC3
Autophagy
|
Cancer
|
|
Pennogenin 3-O-beta-chacotrioside is an active component isolated from Paris polyphylla, modulates autophagy via increasing the expressions of autophagy-related proteins LC3 and Beclin-1. Anti-colorectal cancer activity .
|
-
- HY-W145556
-
|
Gal beta(1-3)GlcNAc beta(1-3)Gal beta(1-4)Glc-beta-pNP
|
Biochemical Assay Reagents
|
Others
|
|
Galβ(1-3)GlcNAcβ(1-3)Galβ(1-4)Glc-β-pNP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-113887
-
-
- HY-101325A
-
|
|
Adrenergic Receptor
|
Metabolic Disease
|
|
BRL-37344 (Fosigotifator (THAM sodium)) is a specific β3-adrenergic receptor agonist. BRL-37344 treatment significantly lowers the body weight of obese mice .
|
-
- HY-173107S
-
-
- HY-N2931
-
|
(+)-β-Rotunol
|
Others
|
Others
|
|
β-Rotunol ((+)-β-Rotunol) is a natural product, that can be isolated from Cyperus rotundus .
|
-
- HY-A0252
-
-
- HY-N2925
-
|
β-Amyron
|
Fungal
COX
PPAR
|
Infection
Metabolic Disease
Inflammation/Immunology
|
|
β-Amyrone (β-Amyron) is a triterpene compound which has anti-inflammatory activity through inhibiting the expression of COX-2. β-Amyrone has antifungal activity , as well as antiviral activity against Chikungunya virus. β-Amyrone also inhibits α-glucosidase and acetylcholinesterase (AChE) activity. β-Amyrone can be used in the research of disease like inflammation, infection, and obesity [2] [3] .
|
-
- HY-N0941
-
|
β-Mangostin
|
Bacterial
Parasite
Apoptosis
|
Infection
Cancer
|
|
beta-Mangostin (β-Mangostin) is a xanthone compound present in Cratoxylum arborescens, with antibacterial and antimalarial activities. beta-Mangostin exhibits antimycobacterial activity against Mycobacterium tuberculosis with an MIC of 6.25 μg/mL. beta-Mangostin possesses in vitro antimalarial activity against Plasmodium falciparum, with an IC50 of 3.00 μg/mL. beta-Mangostin has potent anticancer activity against various cancers (such as hepatocellular carcinoma, leukaemic) [2] [3] .
|
-
- HY-N2920
-
|
11-Oxo-β-amyrin
|
Cytochrome P450
|
Inflammation/Immunology
Cancer
|
|
β-Amyrenonol (11-Oxo-β-amyrin), an oleanolic-type triterpenoid in licorice roots, is a precursor of Glycyrrhetinic acid. β-Amyrenonol has anti-proliferative and anti-inflammatory activities, and β-Amyrenonol could function as the skeleton for the synthesis of many triterpenoids [2].
|
-
- HY-16702
-
|
PFT β; Cyclic Pifithrin-α
|
MDM-2/p53
|
Cancer
|
|
Pifithrin-β (PFT β) is a potent p53 inhibitor with an IC50 of 23 μM.
|
-
- HY-N1601
-
|
2β,6β,15α-(-)-Kaur-16-ene
|
Others
|
Others
|
|
2β,6β,15α-Trihydroxy-ent-kaur-16-ene (compound 19) is a compound isolated from the aerial parts of Pteris cretica .
|
-
- HY-P990002
-
|
|
c-Kit
|
Cancer
|
|
Anti-Mouse CD117/c-Kit Antibody (2B8) is an IgG2b antibody inhibitor against mouse CD117. Derived from rat.
|
-
- HY-N2277
-
-
- HY-P9967
-
|
BIIB037
|
Amyloid-β
|
Neurological Disease
|
|
Aducanumab (BIIB037) is a human monoclonal antibody that selectively targets aggregated amyloid-beta (Aβ). Aducanumab shows brain penetration, and can be used for Alzheimer's disease (AD) research .
|
-
- HY-P3908
-
|
|
Amyloid-β
|
Neurological Disease
|
|
FITC-β-Ala-Amyloid β-Protein (1-42) ammonium is a FITC tagged Aβ1-42 monomer peptide. Aβ1-42 plays a key role in the pathogenesis of Alzheimer’s disease .
|
-
- HY-N13537
-
|
|
Others
|
Others
|
|
11β,13-Dihydrotaraxinic acid β-D-glucopyranosyl ester is a natural product that can be isolated from Punica granatum .
|
-
- HY-14300A
-
-
- HY-130553
-
|
β-NAAG; β-N-Acetylaspartylglutamic acid
|
Aminopeptidase
mGluR
|
Neurological Disease
|
|
β-Spaglumic acid (β-NAAG) is a competitive NAAG peptidase inhibitor (Ki=1 µM) that protects spinal cord neurons from excitotoxicity and hypoxic damage. β-Spaglumic acid is also a selective mGluR3 antagonist (mGluR3 receptor functions to regulate activity-dependent synaptic potentiation in the hippocampus). β-Spaglumic acid can be used in neuroprotection-related studies [2].
|
-
- HY-100206
-
|
|
AMPK
|
Neurological Disease
|
|
5α-Androstane-3β,5,6β-triol is a neuroprotectant. 5α-Androstane-3β,5,6β-triol can remarkably reverse intracellular acidification and alleviate neuronal injury through the inhibition of AMPK signaling. 5α-Androstane-3β,5,6β-triol remarkably reduced the infarct volume and attenuated neurologic impairment in acute ischemic stroke models of middle cerebral artery occlusion in vivo .
|
-
- HY-117378A
-
|
KRP-204 hydrochloride
|
Adrenergic Receptor
|
Inflammation/Immunology
Cancer
|
|
N-5984 (KRP-204) hydrochloride is a potent and selective agonist of β3-adrenergic receptor. N-5984 hydrochloride can be used for research of obesity and diabetes mellitus .
|
-
- HY-15378
-
|
ZD2079 hydrochloride
|
Adrenergic Receptor
|
Cardiovascular Disease
|
|
Talibegron hydrochloride (ZD2079 hydrochloride) is a potent β3-adrenoceptor agonist with a pD2 of 3.72 on phenylephrine-preconstricted rat mesenteric artery. Talibegron hydrochloride has potent vasorelaxant effect .
|
-
- HY-N7364
-
|
trans-β-Farnesene
|
Fungal
CDK
|
Infection
Cancer
|
|
(E)-β-Farnesene (trans-β-Farnesene) is an aphid alarm pheromone, which can be found in Phlomis aurea Decne essential oil. (E)-β-Farnesene shows good binding score with a value of -30.64 kcal/mol to the CDK2 receptor. (E)-β-Farnesene also exhibits good affinity to odorant-binding protein 3 (OBP3). (E)-β-Farnesene can be used as a feeding stimulant for the sand fly Lutzomyia longipalpis [2] [3] .
|
-
- HY-N10364
-
|
|
Others
|
Cancer
|
|
6β,7β-Epoxyasteriscunolide A, a sesquiterpenoid, shows cytotoxicity against the HL-60 and MOLT-3 leukemia cell lines, with IC50s range 4.1-5.4 μM .
|
-
- HY-152095
-
|
|
Ras
|
Cancer
|
|
PPI-GIT1/β-Pix interaction-IN-1 is a potent and orally active GIT1/β-Pix protein-protein interaction (PPI) inhibitor with a KD value of 7.7 µM. PPI-GIT1/β-Pix interaction-IN-1 disrupts the GIT/PIX interaction can impact the activation of the downstream Rho GTPase Rac1 and Cdc42. PPI-GIT1/β-Pix interaction-IN-1 inhibits metastasis of gastric cancer .
|
-
- HY-155735
-
|
|
iGluR
Cholinesterase (ChE)
Amyloid-β
|
Neurological Disease
|
|
AChE/Aβ-IN-2 (compound 33) is a potent and orally active inhibitor of acetylcholinesterase (AChE) with IC50 of 135 nM, as well as an antagonist of NMDA receptor (GluN1-1b/GluN2B subunit combination) with IC50 of 5.054 μM. AChE/Aβ-IN-2 also inhibits Aβ aggregation and shows good blood-brain barrier permeability. AChE/Aβ-IN-2 improves cognitive and spatial memory impairment in rats model .
|
-
- HY-155733
-
|
|
iGluR
Cholinesterase (ChE)
Amyloid-β
|
Neurological Disease
|
|
AChE/Aβ-IN-1 (compound 32) is a potent and orally active inhibitor of acetylcholinesterase (AChE) with an IC50 of 86 nM, as well as an antagonist of NMDA receptor (GluN1-1b/GluN2B subunit combination) with IC50 of 3.876 μM. AChE/Aβ-IN-1 also inhibits Aβ aggregation and shows good blood-brain barrier permeability and neuroprotection. AChE/Aβ-IN-1 improves cognitive and spatial memory impairment in rats model .
|
-
- HY-100543
-
|
ICI-118551
|
Adrenergic Receptor
|
Inflammation/Immunology
|
|
Zenidolol (ICI-118551) is a selective β2 adrenergic receptor antagonist. Zenidolol inhibits β2-, β1- and β3-adrenergic receptor with Ki values of 0.7, 49.5 and 611 nM, respectively. Zenidolol can be used as an ocular hypotensive agent used for ophthalmic disease research .
|
-
- HY-110074
-
|
|
Others
|
Others
|
|
TWS119 TFA is a specific inhibitor of GSK-3β, with an IC50 of 30 nM, and activates the wnt/β-catenin pathway.
|
-
- HY-120223
-
|
|
Adrenergic Receptor
|
Metabolic Disease
|
|
BMS-196085 is an orally active, potent and selective full agonist against human β3 adrenergic receptor with a Ki value of 21 nM. BMS-196085 also has partial agonist activity at the β1 receptor. BMS-196085 is promising for research of obesity and type-II diabetes [2].
|
-
- HY-108059
-
|
(3R)-β-Cryptoxanthin
|
Endogenous Metabolite
|
Neurological Disease
|
|
β-Cryptoxanthin ((3R)-β-Cryptoxanthin), isolated from tangerines, red peppers, and pumpkin, is an oxygenated carotenoid and a potent antioxidant. β-Cryptoxanthin has an anti-stress effect .
|
-
- HY-N9170
-
|
|
Others
|
Cancer
|
|
Lup-20(29)-ene-3β,11β-diol is a natural triterpenoid with anticancer effects. Lup-20(29)-ene-3β,11β-diol exhibits significant cytotoxic activity against HeLa with an IC50 value of 28.5 μM .
|
-
- HY-N1222
-
|
|
Others
|
Others
|
|
Stigmast-4-ene-3β,6β-diol is a stigmasterol, that can be isolated from Nux Prinsepiae .
|
-
- HY-132723AS
-
-
- HY-132723S
-
-
- HY-108229
-
|
6β-Hydroxynaltrexone
|
Drug Metabolite
Opioid Receptor
|
Neurological Disease
|
|
6β-Naltrexol (6β-Hydroxynaltrexone), the primary metabolite of Naltrexone, is a peripherally selective opioid antagonist. 6β-Naltrexol selectively inhibits gastrointestinal opioid effects in human subjects and inhibits Morphine-induced slowing of gastrointestinal transit .
|
-
- HY-14300
-
-
- HY-W414824
-
|
|
Endogenous Metabolite
|
Neurological Disease
|
|
3β,7β-Dihydroxy-5-cholestenoic acid is a C27 acid that displays elevated levels in Niemann-Pick type C and Niemann-Pick type B diseases, contributing to toxicity in oculomotor neurons. It is synthesized from 3β-hydroxy-7-oxocholest-5-en-(25R)26-oic acid (3βH,7O-CA) through the enzymatic action of hydroxysteroid 11-β dehydrogenase 1.
|
-
- HY-P5968
-
|
β(25-35)KA
|
Amyloid-β
|
Neurological Disease
|
|
[Ala28]-β Amyloid(25-35) (β(25-35)KA) is an electrically neutral mutant peptide of Aβ(25-35) that accelerates the aggregation of Firefly Luciferase .
|
-
![[Ala28]-β Amyloid(25-35)](//file.medchemexpress.com/product_pic/hy-p5968.gif)
- HY-17031
-
|
Sulfobutylether-β-Cyclodextrin
|
Biochemical Assay Reagents
|
Others
|
|
SBE-β-CD is a sulfobutylether β-cyclodextrin derivative used as an excipient or a formulating agent to increase the solubility of poorly soluble agents .
|
-
- HY-P1084
-
|
β-PMTX
|
Sodium Channel
|
Neurological Disease
|
|
β-Pompilidotoxin (β-PMTX), a wasp venom, can slow sodium channel inactivation and increases steady-state sodium current in cells .
|
-
- HY-P1051
-
|
Amyloid β-Protein (12-28)
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (12-28) (Amyloid β-Protein (12-28)) is a peptide fragment of β-amyloid protein (β1-42). β1-42, a 42 amino acid protein , is the major component of senile plaque cores. β-Amyloid (12-28) shows aggregation properties. β-Amyloid (12-28) has the potential for Alzheimer’s disease research .
|
-
- HY-N13374
-
|
|
Others
|
Others
|
|
Stigmasta-4,22-diene-3beta,6beta-diol is a natural product .
|
-
- HY-N7606
-
|
|
Others
|
Others
|
|
(Rac)-β-Chamigrenic acid is a racemate of β-Chamigrenic acid. β-Chamigrenic acid is a sesquiterpenoid isolated from S.chinensis
|
-
- HY-P2998
-
-
- HY-N3146
-
|
(3β,4β)-Olean-12-ene-3,23-diol; 3β,24-Dihydroxyolean-12-ene
|
Others
|
Others
|
|
Olean-12-ene-3β,24-diol ((3β,4β)-Olean-12-ene-3,23-diol) is a product that can be isolated from .
|
-
- HY-137781
-
-
- HY-W145607
-
|
Gal beta(1-3)GalNAc-beta-pNP
|
Biochemical Assay Reagents
|
Others
|
|
Galβ(1-3)GalNAc-β-pNP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W145631
-
|
GalNAc beta(1-4)GlcNAc-beta-pNP
|
Biochemical Assay Reagents
|
Others
|
|
GalNAcβ(1-4)GlcNAc-β-pNP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W145558
-
|
Gal beta(1-4)Glc-beta-MP
|
Biochemical Assay Reagents
|
Others
|
|
Galβ(1-4)Glc-β-MP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W699164
-
|
Benzyl β-D-galactopyranosyl-(1→4)-β-D-N-acetylglucosamine
|
Biochemical Assay Reagents
|
Others
|
|
Gal1-β-4GlcNAc-β-Bn (Benzyl β-D-galactopyranosyl-(1→4)-β-D-N-acetylglucosamine) is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-111490R
-
|
CIC-AP(Standard); Ciclesonide Active principle (Standard)
|
Glucocorticoid Receptor
|
Inflammation/Immunology
Endocrinology
|
|
Desisobutyryl-ciclesonide (Standard) is the analytical standard of Desisobutyryl-ciclesonide. This product is intended for research and analytical applications. Desisobutyryl-ciclesonide is the active metabolite of Ciclesonide. Desisobutyryl-ciclesonide has affinity for the glucocorticoid receptor.
|
-
- HY-RS04249
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
EIF2B2 Human Pre-designed siRNA Set A contains three designed siRNAs for EIF2B2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
EIF2B2 Human Pre-designed siRNA Set A
EIF2B2 Human Pre-designed siRNA Set A
- HY-RS01197
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
ATP2B4 Human Pre-designed siRNA Set A contains three designed siRNAs for ATP2B4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
ATP2B4 Human Pre-designed siRNA Set A
ATP2B4 Human Pre-designed siRNA Set A
- HY-RS12819
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
SH2B2 Human Pre-designed siRNA Set A contains three designed siRNAs for SH2B2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
SH2B2 Human Pre-designed siRNA Set A
SH2B2 Human Pre-designed siRNA Set A
- HY-RS15437
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
UGT2B10 Human Pre-designed siRNA Set A contains three designed siRNAs for UGT2B10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
UGT2B10 Human Pre-designed siRNA Set A
UGT2B10 Human Pre-designed siRNA Set A
- HY-RS15441
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
UGT2B7 Human Pre-designed siRNA Set A contains three designed siRNAs for UGT2B7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
UGT2B7 Human Pre-designed siRNA Set A
UGT2B7 Human Pre-designed siRNA Set A
- HY-RS08010
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
MAN2B1 Human Pre-designed siRNA Set A contains three designed siRNAs for MAN2B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
MAN2B1 Human Pre-designed siRNA Set A
MAN2B1 Human Pre-designed siRNA Set A
- HY-RS15440
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
UGT2B4 Human Pre-designed siRNA Set A contains three designed siRNAs for UGT2B4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
UGT2B4 Human Pre-designed siRNA Set A
UGT2B4 Human Pre-designed siRNA Set A
- HY-RS01196
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
ATP2B3 Human Pre-designed siRNA Set A contains three designed siRNAs for ATP2B3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
ATP2B3 Human Pre-designed siRNA Set A
ATP2B3 Human Pre-designed siRNA Set A
- HY-RS01194
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
ATP2B1 Human Pre-designed siRNA Set A contains three designed siRNAs for ATP2B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
ATP2B1 Human Pre-designed siRNA Set A
ATP2B1 Human Pre-designed siRNA Set A
- HY-RS04251
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
EIF2B4 Human Pre-designed siRNA Set A contains three designed siRNAs for EIF2B4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
EIF2B4 Human Pre-designed siRNA Set A
EIF2B4 Human Pre-designed siRNA Set A
- HY-RS03456
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
CYP2B6 Human Pre-designed siRNA Set A contains three designed siRNAs for CYP2B6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
CYP2B6 Human Pre-designed siRNA Set A
CYP2B6 Human Pre-designed siRNA Set A
- HY-RS04250
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
EIF2B3 Human Pre-designed siRNA Set A contains three designed siRNAs for EIF2B3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
EIF2B3 Human Pre-designed siRNA Set A
EIF2B3 Human Pre-designed siRNA Set A
- HY-RS00786
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
AP2B1 Human Pre-designed siRNA Set A contains three designed siRNAs for AP2B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
AP2B1 Human Pre-designed siRNA Set A
AP2B1 Human Pre-designed siRNA Set A
- HY-RS04248
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
EIF2B1 Human Pre-designed siRNA Set A contains three designed siRNAs for EIF2B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
EIF2B1 Human Pre-designed siRNA Set A
EIF2B1 Human Pre-designed siRNA Set A
- HY-RS14021
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
SULT2B1 Human Pre-designed siRNA Set A contains three designed siRNAs for SULT2B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
SULT2B1 Human Pre-designed siRNA Set A
SULT2B1 Human Pre-designed siRNA Set A
- HY-RS12818
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
SH2B1 Human Pre-designed siRNA Set A contains three designed siRNAs for SH2B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
SH2B1 Human Pre-designed siRNA Set A
SH2B1 Human Pre-designed siRNA Set A
- HY-RS15439
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
UGT2B17 Human Pre-designed siRNA Set A contains three designed siRNAs for UGT2B17 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
UGT2B17 Human Pre-designed siRNA Set A
UGT2B17 Human Pre-designed siRNA Set A
- HY-RS06262
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
HNRNPA2B1 Human Pre-designed siRNA Set A contains three designed siRNAs for HNRNPA2B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
HNRNPA2B1 Human Pre-designed siRNA Set A
HNRNPA2B1 Human Pre-designed siRNA Set A
- HY-RS12820
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
SH2B3 Human Pre-designed siRNA Set A contains three designed siRNAs for SH2B3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
SH2B3 Human Pre-designed siRNA Set A
SH2B3 Human Pre-designed siRNA Set A
- HY-RS13356
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
SLCO2B1 Human Pre-designed siRNA Set A contains three designed siRNAs for SLCO2B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
SLCO2B1 Human Pre-designed siRNA Set A
SLCO2B1 Human Pre-designed siRNA Set A
- HY-RS08011
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
MAN2B2 Human Pre-designed siRNA Set A contains three designed siRNAs for MAN2B2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
MAN2B2 Human Pre-designed siRNA Set A
MAN2B2 Human Pre-designed siRNA Set A
- HY-RS01195
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
ATP2B2 Human Pre-designed siRNA Set A contains three designed siRNAs for ATP2B2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
ATP2B2 Human Pre-designed siRNA Set A
ATP2B2 Human Pre-designed siRNA Set A
- HY-RS04252
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
EIF2B5 Human Pre-designed siRNA Set A contains three designed siRNAs for EIF2B5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
EIF2B5 Human Pre-designed siRNA Set A
EIF2B5 Human Pre-designed siRNA Set A
- HY-RS15438
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
UGT2B15 Human Pre-designed siRNA Set A contains three designed siRNAs for UGT2B15 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
UGT2B15 Human Pre-designed siRNA Set A
UGT2B15 Human Pre-designed siRNA Set A
- HY-122028
-
|
|
11β-HSD
|
Metabolic Disease
|
|
HSD-016 is a potent, selective and orally active 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with IC50 values of 11, 1 and 8 nM against human, mouse and rat 11β-HSD1, respectively. HSD-016 can be used for type 2 diabetes research .
|
-
- HY-152073
-
|
|
Fluorescent Dye
|
Others
|
|
BETA-1 is the first twisted intramolecular charge transfer (TICT)-aggregation-induced emission (AIE) integration molecule. BETA-1 emits cyan fluorescence in lipid droplets (LDs) and red fluorescence in mitochondria. BETA-1 can be used for the simultaneous and dual-color imaging of LDs and mitochondria in vivo and in vitro .
|
-
- HY-151260
-
|
|
Beta-secretase
Cholinesterase (ChE)
GSK-3
|
Neurological Disease
|
|
AChE/BACE1/GSK3β-IN-1 is an orally active triple inhibitor of AChE/BACE1/GSK3β. AChE/BACE1/GSK3β-IN-1 has effective inhibitory activity against AChE, BACE1 and GSK3β with IC50 values of 1.0 μM, 20 μM and 15 μM, respectively. AChE/BACE1/GSK3β-IN-1 has good blood-brain barrier penetrability, suitable bioavailability. AChE/BACE1/GSK3β-IN-1 can be used for the research of Alzheimer's disease (AD) .
|
-
- HY-101320
-
|
ICI-D 7114
|
Adrenergic Receptor
|
Endocrinology
|
|
ZD-7114 is a potent and selective agonist of β3-adrenergic. ZD-7114 is a selective thermogenic agent in vivo. ZD-7114 can be used in study obesity and diabetes .
|
-
- HY-101320A
-
|
ICI-D 7114 hydrochloride
|
Adrenergic Receptor
|
Endocrinology
|
|
ZD-7114 hydrochloride is a potent and selective agonist of β3-adrenergic. ZD-7114 hydrochloride is a selective thermogenic agent in vivo. ZD-7114 hydrochloride can be used in study obesity and diabetes .
|
-
- HY-101103
-
|
(2-Hydroxypropyl)-β-cyclodextrin
|
Biochemical Assay Reagents
|
Cancer
|
|
HP-β-CD ((2-Hydroxypropyl)-β-cyclodextrin) is a widely used drug delivery vehicle to improve the stability and bioavailability.
|
-
- HY-165277
-
|
|
Angiotensin-converting Enzyme (ACE)
|
Cardiovascular Disease
|
|
ε-Biotinamidocaproyl-β-alanyl-β-alanyl-lisinopril is an angiotensin-converting enzyme (ACE) inhibitor. Structurally, ε-Biotinamidocaproyl-β-alanyl-β-alanyl-lisinopril is a biotinylated derivative of lisinopril (HY-18206), with a chemical structure linking the biotin molecule and the lisinopril molecule composed of 19 atoms. ε-Biotinamidocaproyl-β-alanyl-β-alanyl-lisinopril can bind to both ACE and streptavidin (HY-P3152) simultaneously, making it possible to separate and purify ACE using streptavidin-agarose beads .
|
-
- HY-B0141C
-
|
β-Estradiol hemihydrate; 17β-Estradiol hemihydrate; 17β-Oestradiol hemihydrate
|
Estrogen Receptor/ERR
Endogenous Metabolite
Bacterial
|
Neurological Disease
Cancer
|
|
Estradiol (β-Estradiol) hemihydrate is a steroid hormone and the major female sex hormone. Estradiol (β-Estradiol) hemihydrate can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol (β-Estradiol) hemihydrate can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering [2].
|
-
- HY-123638
-
-
- HY-107043
-
-
- HY-P0128F1
-
|
|
Amyloid-β
|
Neurological Disease
|
|
FITC-β-Ala-β-Amyloid (25-35) is a fluorescent product labeled by FITC that can be used in Alzheimer's disease research .
|
-
- HY-N1202
-
|
Sitostane-3β,5α,6β-triol
|
Others
|
Others
|
|
Sitostanetriol (Sitostane-3β,5α,6β-triol) is a steroid isolated from Casearia membranacea (Flacourtiaceae) .
|
-
- HY-N6018
-
|
|
Caspase
TNF Receptor
SOD
Reactive Oxygen Species
|
Inflammation/Immunology
Cancer
|
|
Beta-Eudesmol has anticancer and anti-inflammatory activities. Beta-Eudesmol can induce apoptosis. Beta-Eudesmol is a neostigmine antagonist. Beta-Eudesmol can antagonize neostigmine-induced neuromuscular failure. Beta-Eudesmol can be used in the study of sepsis diseases. Beta-Eudesmol is a sesquiterpene-like compound that can be extracted from the rhizome of Atractylodes lancea [2] [3] .
|
-
- HY-106499A
-
-
- HY-N2337
-
|
11β-Hydroxyprogesterone
|
11β-HSD
|
Cardiovascular Disease
|
|
11beta-Hydroxyprogesterone is a potent inhibitors of 11β-Hydroxysteroid dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED50 of 10 nM.
|
-
- HY-12292
-
|
|
GSK-3
|
Cancer
|
|
IM-12 is an inhibitor of GSK-3β, with an IC50 of 53 nM, and also enhances Wnt signalling.
|
-
- HY-116284A
-
|
Methyl β-D-glucoside hemihydrate
|
Others
|
Others
|
|
Methyl β-D-glucopyranoside (Methyl β-D-glucoside) hemihydrate is a hemihydrate compound. Methyl β-D-glucopyranoside hemihydrate less reactive at higher PH. The formation of Methyl β-D-glucopyranoside hemihydrate is stereospecific [2].
|
-
- HY-142279S
-
-
- HY-113068
-
|
|
Tyrosinase
|
Metabolic Disease
|
|
(rel)-β-Tocopherol is a relative configuration of β-Tocopherol.(±)-β-Tocopherol is a lipid-soluble form of vitamin E with antioxidant activity. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol .
|
-
- HY-113482
-
|
1β-OH-DCA
|
Endogenous Metabolite
Cytochrome P450
|
Metabolic Disease
|
|
1β-Hydroxydeoxycholic acid (1β-OH-DCA), a secondary bile acid, is a CYP3A biomarker. Deoxycholic acid is specifically metabolized into 1β-Hydroxydeoxycholic acid by CYP3A4 and CYP3A7 using recombinant human CYP450 enzymes .
|
-
- HY-107324R
-
|
|
Apoptosis
|
Cancer
|
|
β-Elemene (Standard) is the analytical standard of β-Elemene. This product is intended for research and analytical applications. β-Elemene ((-)-β-Elemene; Levo-β-elemene) is isolated from natural plant Curcuma aromatica with an antitumor activity. β-Elemene can induce cell apoptosis.
|
-
- HY-P0117
-
|
Tat-NR2bct; NA-1
|
iGluR
NO Synthase
|
Neurological Disease
|
|
Tat-NR2B9c (Tat-NR2Bct; NA-1) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC50 values of 0.5 μM and 8 μM, respectively. Tat-NR2B9c also inhibits?neuronal nitric oxide synthase (nNOS)/PSD-95?interaction, and possesses neuroprotective efficacy [2] .
|
-
- HY-107529
-
|
|
GSK-3
|
Neurological Disease
Metabolic Disease
|
|
TC-G 24 (Compound 24) is a potent, selective glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 of 17.1 nM. TC-G 24 can cross the BBB and can be used for studying many diseases such as type 2 diabetes mellitus, stroke, Alzheimer, and other related diseases .
|
-
- HY-113630A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
20β-22-Azacholesterol is the β-configuration of 22-Azacholesterol (HY-113630). 20β-22-Azacholesterol is an inhibitor for cholesterol side chain cleavage reactions .
|
-
- HY-N13258
-
|
β-Citrylglutamic acid
|
Others
|
Others
|
|
β-Citryl-L-glutamic acid (β-Citrylglutamic acid) is a citrylglutamic acid, that can be isolated from newborn rat brain .
|
-
- HY-125396
-
|
11-Deoxy-PGF2β
|
Endogenous Metabolite
|
Others
|
|
11-Deoxyprostaglandin F2β (11-deoxy PGF2β) is an analog of PGF2β (HY-12956B). PGF2β is a metabolite produced by cyclooxygenase metabolism of arachidonic acid. PGF2β induces dose-dependent release of hexose containing mucin [2] [3].
|
-
- HY-130046S1
-
-
- HY-P99355
-
|
Anti-ACVR2b Reference Antibody; BYM338
|
TGF-β Receptor
|
Metabolic Disease
|
|
Bimagrumab (Anti-ACVR2B Reference Antibody) is a human monoclonal antibody that blocks activin type II receptor (ActRII), with KDs of 1.7 pM and 434 pM for human ActRIIB and ActRIIA, respectively. Bimagrumab can be used for the research of pathological muscle loss and weakness [2].
|
-
- HY-W012875
-
|
β-Nitropropionic acid; Bovinocidin
|
Bacterial
Apoptosis
Autophagy
|
Infection
Metabolic Disease
|
|
3-Nitropropanoic acid (β-Nitropropionic acid) is an irreversible and orally active inhibitor of succinate dehydrogenase. 3-Nitropropanoic acid exhibits potent antimycobacterial activity with a MIC value of 3.3 μM. 3-Nitropropanoic acid can induce cell apoptosis [2].
|
-
- HY-W129233
-
|
Dihydroartemisinin (α,β mixture)
|
Parasite
Autophagy
Apoptosis
|
Infection
Cancer
|
|
Dihydroartemisinin (mixture of α and β isomers) is an anti-malaria and anticancer agent, as well as an active metabolite of artemisinin and its derivatives. Dihydroartemisinin exerts anticancer effects through various molecular mechanisms, such as inhibiting proliferation, inducing apoptosis, inhibiting tumor metastasis and angiogenesis, promoting immune function, inducing autophagy and endoplasmic reticulum stress .
|
-
- HY-14300AS
-
-
- HY-N1035
-
|
|
Others
|
Others
|
|
Urs-12-ene-3β,16β,22α-triol is a terpenoid compound isolated from the ethanol extract of fresh aerial parts of the Patagonian shrub Nardophyllum bryoides .
|
-
- HY-117378
-
|
KRP-204
|
Adrenergic Receptor
|
Inflammation/Immunology
Cancer
|
|
N-5984 (KRP-204) is a potent and selective agonist of β3-adrenergic receptor. N-5984 has the potential for developing as one of the clinically effective drugs for obesity and diabetes mellitus .
|
-
- HY-P0128
-
|
Amyloid beta-peptide (25-35); Aβ25-35; β-Amyloid peptide (25-35)
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (25-35) (Amyloid beta-peptide (25-35)) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide, has shown neurotoxic activities in cultured cells .
|
-
- HY-W145521
-
|
β Glucan
|
Biochemical Assay Reagents
|
Others
|
|
β-1,3-Glucan is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-114850
-
-
- HY-P1051A
-
|
Amyloid β-Protein (12-28) (TFA); Amyloid beta-Peptide (12-28) (human) TFA; β-Amyloid protein fragment(12-28) TFA
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (12-28) (TFA) (Amyloid β-Protein (12-28) (TFA)) is a peptide fragment of β-amyloid protein (β1-42). β1-42, a 42 amino acid protein , is the major component of senile plaque cores. β-Amyloid (12-28) (TFA) shows aggregation properties. β-Amyloid (12-28) (TFA) has the potential for Alzheimer’s disease research .
|
-
- HY-N0378
-
|
Mannitol; Mannite
|
Endogenous Metabolite
Apoptosis
Adrenergic Receptor
PGC-1α
PKA
|
Cardiovascular Disease
Metabolic Disease
Cancer
|
|
D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β3-adrenergic receptor (β3-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells [2] [3] .
|
-
- HY-W416287
-
-
- HY-106578
-
|
LM 208
|
5-HT Receptor
|
Neurological Disease
|
|
Quinupramine is an orally active antidepressant. Quinupramine can penetrate into the CNS and affect some of the processes of neurotransmission. The antidepressant activity of quinupramine is associated with the central serotonin system, but not with the β-adrenergic system[1][2].
|
-
- HY-W243244
-
-
- HY-160416
-
-
- HY-103520
-
|
|
GABA Receptor
|
Neurological Disease
|
|
DS2 is a selective positive allosteric modulator of δ-GABAA receptor. DS2 selectively potentiates GABA responses mediated by α4β3δ receptor. DS2 does not enhance activity at α4β3γ2 and α1β3γ2 receptors. DS2 relieves pain and has the potential for sleep disorders research .
|
-
- HY-117194
-
|
|
HIV
GSK-3
|
Infection
|
|
18BIOder is a neuroprotective GSK-3β inhibitor, highly selectively inhibiting HIV-1 .
|
-
- HY-W015084AR
-
|
|
Apoptosis
|
Cancer
|
|
(E)-β-Ionone (Standard) is the analytical standard of (E)-β-Ionone. This product is intended for research and analytical applications. (E)-β-Ionone is the isomer of β-Ionone (HY-W015084). β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. β-Ionone has anti-cancer activity .
|
-
- HY-B0445A
-
|
β-DPN sodium; β-NAD sodium; β-Nicotinamide Adenine Dinucleotide sodium
|
Endogenous Metabolite
|
Metabolic Disease
|
|
NAD (β-Nicotinamide Adenine Dinucleotide) sodium is an analogue of NAD. NAD sodium can be reduced to β-nicotinamide adenine dinucleotide (NADH) during coupling with reactions which oxidize organic substrates. NAD sodium can be converted to β-nicotinamide adenine dinucleotide (NADH) and passes to the inside of mitochondria that indirectly generates ATP .
|
-
- HY-123449
-
|
|
Adrenergic Receptor
|
Cardiovascular Disease
|
|
MK-761 free base is a potent and orally active β2-adrenergic blocker. MK-761 free base shows antihypertensive and positive inotropic effects. MK-761 free base shows vasodilating properties .
|
-
- HY-113068R
-
|
|
Tyrosinase
|
Metabolic Disease
|
|
(rel)-β-Tocopherol (Standard) is the analytical standard of (rel)-β-Tocopherol. This product is intended for research and analytical applications. (rel)-β-Tocopherol is a relative configuration of β-Tocopherol.(±)-β-Tocopherol is a lipid-soluble form of vitamin E with antioxidant activity. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol .
|
-
- HY-W145663
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Gal-β1,3-GalNAc-β-OMe is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-N5112A
-
|
Arnebin 1
|
HIF/HIF Prolyl-Hydroxylase
|
Others
|
|
β,β-Dimethylacrylalkannin (Arnebin 1) is a napthoquinone isolated from Alkanna cappadocica , increases collagen and involucrin content in skin cells .
|
-
- HY-RS12843
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
SH3PXD2B Human Pre-designed siRNA Set A contains three designed siRNAs for SH3PXD2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
SH3PXD2B Human Pre-designed siRNA Set A
SH3PXD2B Human Pre-designed siRNA Set A
- HY-RS14240
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
TBC1D2B Human Pre-designed siRNA Set A contains three designed siRNAs for TBC1D2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
TBC1D2B Human Pre-designed siRNA Set A
TBC1D2B Human Pre-designed siRNA Set A
- HY-RS10515
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
Pik3c2b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pik3c2b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
Pik3c2b Mouse Pre-designed siRNA Set A
Pik3c2b Mouse Pre-designed siRNA Set A
- HY-RS10514
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
PIK3C2B Human Pre-designed siRNA Set A contains three designed siRNAs for PIK3C2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
PIK3C2B Human Pre-designed siRNA Set A
PIK3C2B Human Pre-designed siRNA Set A
- HY-RS11012
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
PPP2R2B Human Pre-designed siRNA Set A contains three designed siRNAs for PPP2R2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
PPP2R2B Human Pre-designed siRNA Set A
PPP2R2B Human Pre-designed siRNA Set A
- HY-RS10516
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
Pik3c2b Rat Pre-designed siRNA Set A contains three designed siRNAs for Pik3c2b gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
Pik3c2b Rat Pre-designed siRNA Set A
Pik3c2b Rat Pre-designed siRNA Set A
- HY-RS10563
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
PIP4K2B Human Pre-designed siRNA Set A contains three designed siRNAs for PIP4K2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
PIP4K2B Human Pre-designed siRNA Set A
PIP4K2B Human Pre-designed siRNA Set A
- HY-N10497
-
|
|
nAChR
|
Neurological Disease
|
|
Dihydro-β-erythroidine is a a competitive nicotinic receptor antagonist. Dihydro-β-erythroidine blocks the discriminative stimulus properties of nicotine. Dihydro-β-erythroidine inhibits the anxiolytic effect of nicotine induced [2].
|
-
- HY-P10617
-
|
|
Endogenous Metabolite
|
Cardiovascular Disease
|
|
Salusin-β is an endogenous bioactive peptide with significant hemodynamic and mitogenic activity. Salusin-β can stimulate the proliferation of quiescent vascular smooth muscle cells (VSMCs) and fibroblasts, leading to a rapid and significant decrease in blood pressure and heart rate. In addition, Salusin-β can stimulate the release of arginine vasopressin from the pituitary gland in rats. This makes Salusin-β have important application potential in cardiovascular disease research .
|
-
- HY-F0004
-
|
β-NM; NMN
|
Endogenous Metabolite
|
Neurological Disease
Cancer
|
|
β-nicotinamide mononucleotide (β-NM) is a product of the nicotinamide phosphoribosyltransferase (NAMPT) reaction and a key NAD + intermediate. The pharmacological activities of β-nicotinamide mononucleotide include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity .
|
-
- HY-B1915
-
|
Gentamicin C2b; Antibiotic XK-62-2; Sagamicin
|
Antibiotic
Bacterial
|
Infection
|
|
Micronomicin (Gentamicin C2b) is an aminoglycoside antibiotic, with antibacterial and bactericidal activities .
|
-
- HY-W019878
-
|
β-Lipotropin 61-91
|
Opioid Receptor
|
Cardiovascular Disease
Neurological Disease
|
|
β-Endorphin, rat (β-Lipotropin 61-91), a neuropeptide, is involved in cardiovascular regulation. β-Endorphin, rat induces marked, prolonged muscular rigidity and immobility similar to a catatonic state in rats [2].
|
-
- HY-P4865
-
-
- HY-P4870
-
-
- HY-P4868
-
-
- HY-125586
-
|
|
DNA/RNA Synthesis
ADC Cytotoxin
|
Cancer
|
|
β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom. β-Amanitin inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis. β-Amanitin can be used as a cytotoxic component of antibody-drug conjugates (ADCs) [2].
|
-
- HY-P1522
-
-
- HY-N6575
-
-
- HY-W127512
-
-
- HY-130570
-
|
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
Beta-gal-nonoate is a β-galactosidase dependent nitric oxide (NO) donor that releases NO once activated by β-galactosidase. β-Gal-NONOate has bactericidal activity and can be used as a bactericide .
|
-
- HY-N9987
-
-
- HY-W357146
-
|
Phenethyl β-D-galactoside
|
Others
|
Others
|
|
2-Phenylethyl β-D-galactopyranoside (Phenethyl β-D-galactoside) can be synthesized catalyzed by Aspergillus oryzae β-galactosidase .
|
-
- HY-19334
-
-
- HY-P1084A
-
|
β-PMTX TFA
|
Sodium Channel
|
Neurological Disease
|
|
β-Pompilidotoxin TFA (β-PMTX TFA), a wasp venom, can slow sodium channel inactivation and increases steady-state sodium current in cells .
|
-
- HY-131171
-
|
3β,5α-NET
|
Drug Derivative
|
Others
|
|
3β,5α-Tetrahydronorethisterone is a tetrahydro derivative of norethindrone (NET) .
|
-
- HY-16702A
-
|
PFT β hydrobromide; Cyclic Pifithrin-α hydrobromide
|
MDM-2/p53
Ferroptosis
|
Cancer
|
|
Pifithrin-β hydrobromide (PFT β hydrobromide) is a potent p53 inhibitor with an IC50 of 23 μM.
|
-
- HY-P1046
-
|
Amyloid β-Protein (1-15)
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (1-15) is a fragment of β-Amyloid peptide. Beta-amyloid is a peptide that forms amyloid plaques in the brains of Alzheimer's disease (AD) patients.
|
-
- HY-B1204S
-
-
- HY-N8453
-
|
Methyl 3,5-dicaffeoyl quinic acid
|
p38 MAPK
|
Neurological Disease
|
|
Macranthoin G is an inhibitor of p38 MAPK. Macranthoin G protects the cytotoxicity induced by Aβ or hydrogen peroxide in neuronal cells by downregulating p38 MAPK. Macranthoin G can used in study Alzheimer’s Disease .
|
-
- HY-N0411
-
|
Provitamin A; beta-Carotene
|
Endogenous Metabolite
Apoptosis
Reactive Oxygen Species
|
Metabolic Disease
Cancer
|
|
β-Carotene (Provitamin A), a carotenoid compound, is a naturally-occurring vitamin A precursor. β-Carotene is a modulator of reactive oxygen species (ROS), with antioxidant and antiinflammatory activities. β-Carotene may serve as an antioxidant or as a prooxidant, depending on its intrinsic properties as well as on the redox potential of the biological environment in which it acts. β-Carotene induces breast cancer cells apoptosis, with anticancer activities [2] [3] .
|
-
- HY-136736
-
|
|
Beta-secretase
|
Neurological Disease
|
|
β-Secretase Inhibitor II is a β-Secretase inhibitor. β-Secretase Inhibitor II is a simple tripeptide aldehyde (IC50=700 nM for inhibition of total Aβ and IC50=2.5 μM for Aβ1–42). β-Secretase Inhibitor II can be used for the research of Alzheimer's disease .
|
-
- HY-P0179
-
-
- HY-N2274
-
|
12-Oleanene-3β,16β,23,28-tetrol; 3β,16β-12-Oleanene-3, 16,23,28-tetrol
|
Others
|
Cancer
|
|
23-Hydroxylongispinogenin (12-Oleanene-3β,16β,23,28-tetrol) is extracted from Lysimachia heterogenea Klatt. Lysimachia heterogenea Klatt is a perennial herb, which is used as a folk medicine in subduing swelling and detoxicating in China. The effective fraction LH-1 of L. heterogene has antitumor activity .
|
-
- HY-144826
-
|
|
GSK-3
|
Neurological Disease
|
|
ZDWX-25 is a highly potent GSK-3β and DYRK1A dual inhibitor with an IC50 value of 71 nM for GSK-3β. ZDWX-25 possesses significant cytotoxic activities against SH-SY5Y and HL-7702 cells. ZDWX-25 can be used for researching alzheimer's disease .
|
-
- HY-130223
-
|
11β-Dinoprostone; 11β-PGE2
|
Prostaglandin Receptor
|
Endocrinology
|
|
11β-Prostaglandin E2 (11β-Dinoprostone), a Prostanoid derivative, inhibits [ 3H]PGE2 binding to hypothalamic membranes in the rat with a Ki of 53.3 nM .
|
-
- HY-N13365
-
|
|
Others
|
Others
|
|
1,10β-Epoxy-6β-isobutanoyloxy-9-oxofuranoeremophilane is a natural product .
|
-
- HY-141672
-
|
17β-Estradiol 3-sulfate sodium
|
GABA Receptor
|
Neurological Disease
|
|
17β-Estradiol sulfate (sodium), also known as β-Estradiol 3-sulfate sodium salt, is a neuroactive steroid [2].
|
-
- HY-162832
-
|
|
Amyloid-β
|
Neurological Disease
|
|
Amyloid-β-IN-1 (compound 13) is a synthetic peptide containing the hydrophobic C-terminal region "VVIA-NH2" and its reverse sequence "AIVV-NH2" of Aβ42, which is an Aβ inhibitor. Amyloid-β-IN-1 can inhibit Aβ aggregation and has neuroprotective effects .
|
-
- HY-P10628
-
|
|
Amyloid-β
|
Neurological Disease
|
|
β Amyloid (1-14), human is a peptide fragment of β-amyloid protein (Aβ), which is obtained by hydrolysis of Aβ1-40 peptide by catalytic antibody light chain #7TR. β Amyloid (1-14), human can be used for Alzheimer's disease research .
|
-
- HY-N6652
-
|
Uracil 1-β-D-arabinofuranoside
|
Others
|
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
|
1-beta-D-Arabinofuranosyluracil (Uracil 1-β-D-arabinofuranoside) isolated from the Caribbean sponge Tectitethya crypta, is a methoxyadenosine derivative. 1-beta-D-Arabinofuranosyluracil has demonstrated a diverse bioactivity profile including anti-inflammatory activity, analgesic and vasodilation properties . 1-beta-D-Arabinofuranosyluracil reduces a proliferation of mouse lymphoma cells [2].
|
-
- HY-P1521
-
|
beta-Amyloid (15-21)
|
Amyloid-β
|
Neurological Disease
|
|
β-amyloid (15-21) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.
|
-
- HY-117266
-
|
beta-D-Galactopyranoside, 98%
|
Biochemical Assay Reagents
|
Others
|
|
β-D-Galactopyranoside, 98% (beta-D-Galactopyranoside, 98%) can be used in glycobiology research.
|
-
- HY-N8090
-
|
|
NO Synthase
|
Inflammation/Immunology
|
|
(3β,7β,12β,20Z)-3,7,12-Trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid, a lanostane triterpenoids, exhibits obvious NO inhibitory activity on n LPS-induced BV-2 microglia cells with an IC50 of 9.55 uM. (3β,7β,12β,20Z)-3,7,12-Trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid has anti-inflammatory activities .
|
-
- HY-113351
-
-
- HY-114464
-
|
4-Androsten-11β-ol-3,17-dione
|
Endogenous Metabolite
11β-HSD
|
Endocrinology
|
|
11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor. As 4-androstenedione increases, measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism [2].
|
-
- HY-117215
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Beta-Ocimene is a naturally occurring organic compound that belongs to the terpene family. It exists as a mixture of three isomers: cis β-Ocimene, trans β-Ocimene and myrcene-like β-Ocimene. It has a pleasant, sweet herbaceous scent and is found in many plants, including mint, basil, parsley, and kumquat. β-Ocimene is widely used in the flavor and fragrance industry due to its characteristic aroma and taste. It also has potential applications in agriculture as natural insect repellants and pheromones that attract beneficial insects. β-Ocimene has potential anti-inflammatory and anticancer activities.
|
-
- HY-N0171R
-
|
β-Sitosterol (Standard); 22,23-Dihydrostigmasterol (Standard))
|
Apoptosis
Endogenous Metabolite
|
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
|
Beta-Sitosterol (Standard) is the analytical standard of Beta-Sitosterol. This product is intended for research and analytical applications. Beta-Sitosterol (Standard) includes β-sitosterol (≥80%), stigmasterol, campesterol and brassicasterol mainly. Beta-Sitosterol is a plant sterol. Beta-Sitosterol (Standard) interfere with multiple cell signaling pathways, including cell cycle, apoptosis, proliferation, survival, invasion, angiogenesis, metastasis and inflammation .
|
-
- HY-N5081
-
|
|
Others
|
Cancer
|
|
1αH,5αH-Guaia-6-ene-4β,10β-diol is a sesquiterpenoid derivative identified from Alisma orientale. 1αH,5αH-Guaia-6-ene-4β,10β-diol has anti-cancer activities .
|
-
- HY-W010934
-
|
|
Biochemical Assay Reagents
|
Others
|
|
3β,5α,6β-Trihydroxycholestane is a steroid that occurs naturally in the body and is also found in certain foods. It belongs to a class of compounds known as cholestanes, which are closely related to the better known cholesterol. This particular compound is formed from cholesterol through a series of enzymatic reactions in the liver and other organs. It has been studied for its potential health benefits, including its ability to reduce inflammation and oxidative stress in the body. Some research suggests that it may also play a role in regulating blood sugar levels and improving insulin sensitivity. Despite these potential benefits, 3β,5α,6β-Trihydroxycholestane is not widely used as a supplement or medicine due to its relatively low content, focus on natural resources and limited research. However, researchers continue to investigate its potential uses and effects on human health.
|
-
- HY-137824
-
|
4-Methylumbelliferyl-β-D-xyloside
|
Biochemical Assay Reagents
|
Others
|
|
4-Methylumbelliferyl-β-D-xylopyranoside (MuX) can be used as substrate for the research of β-Xylosidase activity. 4-Methylumbelliferyl-β-D-xylopyranoside shows burst, steady-state kinetics, which supports the conclusion that hydrolysis of the glycosidic bonds for the substrate 4-Methylumbelliferyl-β-D-xylopyranoside is rapid [2].
|
-
- HY-P2869A
-
|
|
Others
|
Metabolic Disease
|
|
β1-3 Galactosidase is a highly specific exoglycosidase that catalyzes the hydrolysis of terminal β1-3-linked galactose from oligosaccharides and glycoprotein substrates, at a much lower rate, β1-6 linked galactose residues from oligosaccharides .
|
-
- HY-108693R
-
|
|
Leukotriene Receptor
|
Inflammation/Immunology
|
|
β-Tocotrienol (Standard) is the analytical standard of β-Tocotrienol. This product is intended for research and analytical applications. β-Tocotrienol is one form of vitamin E. β-Tocotrienol is a less potent antioxidant than α-tocotrienol .
|
-
- HY-N3604
-
|
2β,9α-Clovanediol; 2β,9α-Dihydroxyclovane; Clovane-2β,9α-diol
|
Others
|
Others
|
|
Clovanediol (2β,9α-Clovanediol) is a product that can be isolated from .
|
-
- HY-147007
-
|
|
β-catenin
Wnt
CDK
|
Cancer
|
|
β-catenin-IN-3 (Compound C2) is a selective β-catenin inhibitor. β-catenin-IN-3 binds to allosteric site on the surface of β-catenin with K D calculated at 54.96 nM. β-catenin-IN-3 selectively inhibits β-catenin via targeting a cryptic allosteric modulation site, lowers its cellular load. β-catenin-IN-3 significantly reduces viability of β-catenin driven cancer cells, and triggers β-catenin degradation via proteasome system in β-catenin-overexpressing cancer cells .
|
-
- HY-P0023
-
|
|
Integrin
|
Cancer
|
|
Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM . Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface [2].
|
-
- HY-E70136
-
|
|
Others
|
Metabolic Disease
|
|
Endo-β-Galactosidase catalyzes the hydrolysis of internal β1-4 galactose linkages in unbranched, repeating poly-N-acetyllactosamine ([GlcNAc- (1-3)Gal- (1-4)]n) structures .
|
-
- HY-N2767
-
|
|
Others
|
Others
|
|
Naphtho[1,2-b]furan, 2-propenoic acid deriv. is a Sesquiterpenoids product that can be isolated from the herbs of Elephantopus scaber .
|
-
![Naphtho[1,2-b]furan, 2-propenoic acid deriv.](//file.medchemexpress.com/product_pic/hy-n2767.gif)
- HY-W154295
-
|
|
Fluorescent Dye
|
Others
|
|
Purple-β-D-Gal is a chromogenic β-galactosidase substrate. Intracellular enzymatic hydrolysis of Purple-β-D-Gal generates free indoxyl molecules, which undergo in situ oxidation and subsequent dimerization to produce chromogenic, water-insoluble, indigo precipitates. Purple-β-D-Gal can be used for the detection of β-galactosidase activity .
|
-
- HY-N7364R
-
|
|
Fungal
|
Infection
Cancer
|
|
(E)-β-Farnesene (Standard) is the analytical standard of (E)-β-Farnesene. This product is intended for research and analytical applications. (E)-β-Farnesene (trans-β-Farnesene) is a volatile sesquiterpene hydrocarbon which can be found in Phlomis aurea Decne essential oil. (E)-β-Farnesene can be used as a feeding stimulant for the sand fly Lutzomyia longipalpis [2].
|
-
- HY-P1481A
-
-
- HY-P2769A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Thermostable β-Agarase is a hydrolase that can hydrolyze the β-1,4 linkages in agarose to produce neoagaro-oligosaccharides, and it can be used to extract DNA and RNA from gels. Compared to conventional β-Agarase, Thermostable β-Agarase exhibits higher heat resistance and stronger hydrolytic activity. The thermostable properties of Thermostable β-Agarase simplify experimental procedures and make it suitable for the rapid purification of intact large DNA molecules .
|
-
- HY-108229S
-
|
6β-Hydroxynaltrexone-d3
|
Isotope-Labeled Compounds
Opioid Receptor
Drug Metabolite
|
Neurological Disease
|
|
6β-Naltrexol-d3 (6β-Hydroxynaltrexone-d3) is deuterium labeled 6β-Naltrexol. 6β-Naltrexol (6β-Hydroxynaltrexone), the primary metabolite of Naltrexone, is a peripherally selective opioid antagonist. 6β-Naltrexol selectively inhibits gastrointestinal opioid effects in human subjects and inhibits Morphine-induced slowing of gastrointestinal transit [2].
|
-
- HY-N11538
-
|
|
Others
|
Inflammation/Immunology
|
|
Quercetin-3-O-(2′′-O-galloyl)-β-D-glucopyranoside is a orally active phenolic compound that can be isolated from the Geranium species. Quercetin-3-O-(2′′-O-galloyl)-β-D-glucopyranoside has anti-inflammatory activities and has potential application in edema and aortic endothelium-dependent relaxation injury .
|
-
- HY-W416255
-
-
- HY-P1474
-
|
Amyloid β-Protein (22-35)
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid 22-35 (Amyloid β-Protein 22-35), the residues 22-35 fragment ofβ-amyloid protein, has a cytotoxic effect on cultured neurons from the rat hippocampus in serum-free medium. β-Amyloid 22-35 forms aggregates and typical amyloid fibrils resembling those of the β-amyloid protein in neutral buffer solution) .
|
-
- HY-146691
-
|
|
Monoamine Oxidase
|
Neurological Disease
|
|
hMAO-B-IN-2 (compound 6j) is an orally active, potent, selective and BBB penetrated and competitive reversible hMAO-B inhibitor, with an IC50 of 4 nM. hMAO-B-IN-2 shows low toxicity and good neuroprotective effects in SH-SY5Y cell. hMAO-B-IN-2 can be used for alzheimer’s disease research . hMAO-B-IN-2 is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-N1968
-
|
Quercetin-3-O-beta-D-glucose-7-O-beta-D-gentiobioside
|
Others
|
Others
|
|
Quercetin-3-O-β-D-glucose-7-O-β-D-gentiobiosiden is a flavonoid from Quercetin.
|
-
- HY-116051A
-
|
16,16-Dimethyl-PGF2β
|
Prostaglandin Receptor
|
Cardiovascular Disease
|
|
16,16-Dimethylprostaglandin F2β (16,16-Dimethyl-PGF2β) is an analog of PGF2β (HY-12956B), which is an irratant, but prevents the aspecifically induced bronchospasm .
|
-
- HY-P1468
-
|
Amyloid β-Protein (1-28)
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (1-28) is a β-Amyloid protein fragment involved in metal binding. Beta-amyloid is a peptide that forms amyloid plaques in the brains of Alzheimer's disease (AD) patients.
|
-
- HY-P1466
-
|
Amyloid β-Protein (1-16)
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (1-16) is a β-Amyloid protein fragment involved in metal binding. Beta-amyloid is a peptide that forms amyloid plaques in the brains of Alzheimer's disease (AD) patients.
|
-
- HY-128976
-
|
DHED
|
Estrogen Receptor/ERR
|
Metabolic Disease
|
|
10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) is a brain-targeting bioprecursor proagent of the main human estrogen, 17β-estradiol, alleviates hot flushes in rat models of thermoregulatory dysfunction of the brain .
|
-
- HY-113478R
-
|
|
Drug Metabolite
|
Metabolic Disease
|
|
3β-Ursodeoxycholic acid (Standard) is the analytical standard of 3β-Ursodeoxycholic acid. This product is intended for research and analytical applications. 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) is a bile acid. 3β-Ursodeoxycholic acid shows good tolerance and well intestinal absorption by oral adminstation. 3β-Ursodeoxycholic acid can be isomerized by intestinal and hepatic enzymes to yield UDCA .
|
-
- HY-119445A
-
|
2-O-beta-D-Glucopyranosyl-D-glucopyranose monohydrate
|
Biochemical Assay Reagents
|
Infection
Others
Cancer
|
|
Sophorose (2-O-beta-D-Glucopyranosyl-D-glucopyranose) monohydrate is the disaccharide component of microbial glycolipids, which are often used as biosurfactants due to their hydrophobicity. Sophorolipids also exhibit antibacterial, antifungal, spermicidal, virucidal, and anticancer activities. In studies of Trichoderma reesei fermentation, sophorose monohydrate has been identified as a potent inducer of cellulase gene expression .
|
-
- HY-N0338R
-
|
|
Others
|
Others
|
|
(-)-Syringaresnol-4-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside (Standard) is the analytical standard of (-)-Syringaresnol-4-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside. This product is intended for research and analytical applications. (-)-Syringaresnol-4-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside is isolated from the bark of Albizia julibrissin .
|
-
- HY-117025A
-
|
Keramamine A hydrochloride
|
GSK-3
CDK
Parasite
Proton Pump
HSV
Autophagy
|
Infection
Neurological Disease
Cancer
|
|
Manzamine A hydrochloride, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC50s of 10.2 μM and 1.5 μM, respectively. Manzamine A hydrochloride targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A hydrochloride has antimalarial and anticancer activities. Manzamine A hydrochloride also shows potent activity against HSV-1 [2] [3] .
|
-
- HY-117025
-
|
Keramamine A
|
GSK-3
CDK
Parasite
Proton Pump
HSV
Autophagy
|
Infection
Neurological Disease
Cancer
|
|
Manzamine A, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC50s of 10.2 μM and 1.5 μM, respectively. Manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A has antimalarial and anticancer activities. Manzamine A also shows potent activity against HSV-1 [2] [3] .
|
-
- HY-E70110
-
|
|
Others
|
Others
|
|
Endo-1,4-β-mannanase is an important catalytic agent that randomly cleave the β-1,4-linkage in the mannan backbone and release short β-1,4-mannooligosaccharides and mannose .
|
-
- HY-W706304
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Gal1-β-4GlcNAc1-β-6Gal is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-113341
-
-
- HY-N11600
-
|
|
Apoptosis
|
Cancer
|
|
β-Apopicropodophyllin is a nature product that could be isolated from Hyptis wticillata.β-Apopicropodophyllin induces apoptosis by inducing microtubule disruption, DNA damage, cell cycle arrest and ER stress. β-Apopicropodophyllin can be used in research of cancer .
|
-
- HY-118614R
-
|
|
Drug Metabolite
|
Neurological Disease
|
|
β-Nicotyrine (Standard) is the analytical standard of β-Nicotyrine. This product is intended for research and analytical applications. β-Nicotyrine is a metabolite of Nicotine.β-Nicotyrine, isolated from the leaves of Nicotiana tabacum plants and from cigarette smoke condensate, is a minor tobacco alkaloid .
|
-
- HY-125849
-
|
Chrysin 7-O-β-gentiobioside
|
Drug Derivative
|
Cancer
|
|
Chrysin 7-O-beta-gentiobioside (Chrysin 7-O-β-gentiobioside) is the glycosylation product of Chrysin .
|
-
- HY-112394
-
|
|
GSK-3
CDK
|
Cancer
|
|
2-Cyanoethylalsterpaullone (compound 7) is an Alsterpaullone (HY-108359) derivative, which exhibits potent and selective inhibitory activities against CDK1/Cyclin B and GSK-3β (GSK-3β: IC50=0.8 nM; CDK1/Cyclin B: IC50=0.23 nM) .
|
-
- HY-P2869C
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
β1-3,4 Galactosidase is a highly specific exoglycosidase that catalyzes the hydrolysis of terminal β1-3 and β1-4 linked galactose residues from oligosaccharides .
|
-
- HY-N0941R
-
|
|
Bacterial
Parasite
Apoptosis
|
Infection
Cancer
|
|
beta-Mangostin (Standard) is the analytical standard of beta-Mangostin. This product is intended for research and analytical applications. beta-Mangostin (β-Mangostin) is a xanthone compound present in Cratoxylum arborescens, with antibacterial and antimalarial activities. beta-Mangostin exhibits antimycobacterial activity against Mycobacterium tuberculosis with an MIC of 6.25 μg/mL. beta-Mangostin possesses in vitro antimalarial activity against Plasmodium falciparum, with an IC50 of 3.00 μg/mL. beta-Mangostin has potent anticancer activity against various cancers (such as hepatocellular carcinoma, leukaemic) [2] [3] .
|
-
- HY-P1468F
-
|
Biotin-amyloid β-protein (1-28)
|
Amyloid-β
|
Others
|
|
Biotin-β-amyloid (1-28) (Biotin-amyloid β-protein (1-28)) is abiotinylated β-Amyloid (1-28) (HY-P1468).
|
-
- HY-W015084AS
-
-
- HY-P0023A
-
|
|
Integrin
|
Cancer
|
|
Cyclo(-RGDfK) TFA is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM . Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface [3].
|
-
- HY-N2454R
-
-
- HY-N0527
-
|
Penta-O-galloyl-β-D-glucose; 1,2,3,4,6-Pentagalloyl glucose
|
JAK
Keap1-Nrf2
Apoptosis
β-catenin
Reactive Oxygen Species
|
Neurological Disease
Inflammation/Immunology
Cancer
|
|
Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) is an orally active gallic tannin compound and an inducer of apoptosis and autophagy. Pentagalloglucose induces cell apoptosis and autophagy through the GSK3β/β-catenin pathway. Pentagalloglucose has antioxidant, anti mutagenic, anti-inflammatory, anticonvulsant, cardioprotective, anti allergic, cholesterol lowering, and anti-tumor activities [2] [3].
|
-
- HY-138089
-
|
|
Androgen Receptor
Estrogen Receptor/ERR
LDLR
|
Metabolic Disease
Cancer
|
|
17β-Hydroxy exemestane (17-H-EXE) is the primary active metabolite of Exemestane (HY-13632). 17β-Hydroxy exemestane is an aromatase inhibitor (IC50 = 69 nM) and an androgen receptor (AR) agonist (IC50 = 39.6 nM) that is selective for AR over estrogen receptor α (ERα; IC50 = 21.2 μM). 17β-Hydroxy exemestane stimulates growth of AR- and ERα-positive MCF-7 (EC50= 2.7 μM) and T47D breast cancer cells (EC50s = 0.43 and 1500 nM for AR- and ER-mediated growth, respectively) and inhibits proliferation of testosterone-treated aromatase-overexpressing MCF-7 cells. 17β-Hydroxy exemestane inhibits increases in serum cholesterol and LDL levels and prevents decreases in bone mineral density in the lumbar vertebrae and femur, as well as femoral bending strength and compressive strength of the fifth lumbar vertebrae in ovariectomized rats [2] [3] .
|
-
- HY-N6741R
-
|
|
Others
|
Infection
Endocrinology
|
|
β-Zearalenol (Standard) is the analytical standard of β-Zearalenol. This product is intended for research and analytical applications. β-Zearalenol is a non-steroidal estrogenic mycotoxin synthesized by Fusarium species. β-Zearalenol potentially influences transcription and effects gene expression on translational level .
|
-
- HY-N5053
-
|
|
Others
|
Others
|
|
Periplogenin 3-[O-β-glucopyranosyl-(1→4)-β-sarmentopyranoside] is a cardenolide isolated from the root barks of Periploca sepium .
|
-
![Periplogenin 3-[O-β-glucopyranosyl-(1→4)-β-sarmentopyranoside]](//file.medchemexpress.com/product_pic/hy-n5053.gif)
- HY-P2858
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
β-Mannosidase is a lysosomal enzyme from the glycosyl hydrolase family 2 that cleaves the single β(1-4)-linked mannose at the nonreducing end of N-glycosylated proteins, and plays an important role in the polysaccharide degradation pathway .
|
-
- HY-N3995
-
|
|
Apoptosis
Drug Metabolite
|
Cancer
|
|
5β-Dihydrocortisol, a metabolite of Cortisol, is a potential mineralocorticoid. 5β-Dihydrocortisol can potentiate glucocorticoid activity in raising the intraocular pressure. 5β-Dihydrocortisol causes breast cancer cell apoptosis [2] [3] .
|
-
- HY-145480
-
|
Silodosin β-D-glucuronide sodium
|
Drug Metabolite
|
Others
|
|
Silodosin Glucuronide sodium (Silodosin β-D-glucuronide sodium) is the metabolite of Silodosin (HY-10122). Silodosin is a selective and orally active antagonist for α1A-adrenergic receptor (α1A-AR) with Ki of 0.036 nM .
|
-
- HY-159422
-
-
- HY-137870
-
|
gamma-Glutamyl-beta-naphthylamide
|
Biochemical Assay Reagents
|
Others
|
|
γ-Glutamyl-β-naphthylamide is a substrate for γ-glutamine peptidase. γ-Glutamyl-β-naphthylamide is specifically recognized and the peptide chain is cleaved. γ-Glutamyl-β-naphthylamide can be used to distinguish between gonococci and meningococci .
|
-
- HY-163652
-
|
|
Others
|
Metabolic Disease
|
|
Glicetanile is an orally active hypoglycemic agent, that stimulates the release of insulin from pancreatic beta cells, and lowers the blood sugar. Glicetanile exhibits potential in ameliorating the type 2 diabetes .
|
-
- HY-108693
-
-
- HY-N1876
-
|
|
Others
|
Neurological Disease
|
|
Aromadendrane-4β,10α-diol is a sesquiterpene alcohol. Aromadendrane-4β,10α-diol significantly ameliorates the Aβ1-42 peptide-induced memory impairment. Aromadendrane-4β,10α-diol can be used for Alzheimer's disease (AD) research .
|
-
- HY-117215R
-
|
|
Biochemical Assay Reagents
|
Others
|
|
β-Ocimene (Standard) is the analytical standard of β-Ocimene. This product is intended for research and analytical applications. Beta-Ocimene is a naturally occurring organic compound that belongs to the terpene family. It exists as a mixture of three isomers: cis β-Ocimene, trans β-Ocimene and myrcene-like β-Ocimene. It has a pleasant, sweet herbaceous scent and is found in many plants, including mint, basil, parsley, and kumquat. β-Ocimene is widely used in the flavor and fragrance industry due to its characteristic aroma and taste. It also has potential applications in agriculture as natural insect repellants and pheromones that attract beneficial insects. β-Ocimene has potential anti-inflammatory and anticancer activities.
|
-
- HY-125932A
-
|
|
Serotonin Transporter
|
Neurological Disease
|
|
9β-Debilon is a sesquiterpenoid compound found in Nardostachys chinensis and may possess SERT regulatory activity. Structurally, 9β-Debilon is a diastereomer of Debilon (HY-125932). 9β-Debilon holds potential for research into neurological disorders .
|
-
- HY-133680R
-
|
|
Tyrosinase
|
Metabolic Disease
|
|
β-Tocopherol (Standard) is the analytical standard of β-Tocopherol. This product is intended for research and analytical applications. β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol [2] [3].
|
-
- HY-147041
-
|
GB1211
|
Galectin
|
Inflammation/Immunology
Cancer
|
|
Selvigaltin (GB1211) is an orally active galectin-3 small molecule inhibitor with an IC50 value of 12 nM in rabbits, showing anti-tumor activity. Selvigaltin decreases galectin-3 levels in the liver and reduces biomarkers of liver function (AST, ALT, bilirubin), inflammation (cells foci) and fibrosis (PSR, SHG), as well as decreasing the mRNA and protein expression of several key inflammation and fibrosis biomarkers (IL6, TGFβ3, SNAI2, collagen). Selvigaltin restores T-cell activity and induces less tumors and metastasis [2] [3] .
|
-
- HY-D1461
-
|
|
Fluorescent Dye
|
Cancer
|
|
Fluorescein Di-β-D-Glucopyranoside is a specific β-glucocerebrosidase substrate that can be used for the intralysosomal β-galactosidase .
|
-
- HY-P1772
-
-
- HY-115843
-
-
- HY-101274A
-
-
- HY-RS10465
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
PI4K2B Human Pre-designed siRNA Set A contains three designed siRNAs for PI4K2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
PI4K2B Human Pre-designed siRNA Set A
PI4K2B Human Pre-designed siRNA Set A
- HY-131108R
-
|
|
Others
|
Others
|
|
β-Aspartylaspartic acid (Standard) is the analytical standard of β-Aspartylaspartic acid. This product is intended for research and analytical applications. β-Aspartylaspartic acid is a natural compound found in Asparagus (Asparagus officinalis) Shoots .
|
-
- HY-N9933
-
|
TβMCA
|
FXR
Apoptosis
|
Metabolic Disease
Cancer
|
|
Tauro-β-muricholic acid (TβMCA) is a trihydroxylated bile acid. Tauro-β-muricholic acid is a competitive and reversible FXR antagonist (IC50 = 40 μM). Tauro-β-muricholic acid has antiapoptotic effect. Tauro-β-muricholic acid inhibits bile acid-induced hepatocellular apoptosis by maintaining the mitochondrial membrane potential [2].
|
-
- HY-N13547
-
|
|
Others
|
Others
|
|
3β,7β-Dihydroxy-25-methoxycucurbita-5,23-dien-19-al is a natural product .
|
-
- HY-132300
-
|
|
β-catenin
|
Cancer
|
|
ZW4864 is an orally active and selective β catenin/B-Cell lymphoma 9 protein−protein interaction (β catenin/BCL9 PPI) inhibitor. ZW4864 inhibits β catenin/BCL9 PPI with a Ki value of 0.76 μM and an IC50 value of 0.87 μM .
|
-
- HY-42822A
-
-
- HY-N2454
-
-
- HY-135386
-
-
- HY-N15333
-
|
|
Insecticide
|
Infection
|
|
β-Terpinyl acetate is a compound with anti-termitic activity, which is found in Lavandula Latifolia. β-Terpinyl acetate is promising for research of natural termiticides .
|
-
- HY-N8695
-
|
|
Others
|
Cancer
|
|
1β-Hydroxybufalin is a bufadienolide that can be isolated from Ch’an Su. 1β-Hydroxybufalin inhibits cancer cell growth .
|
-
- HY-16143
-
|
EMD 121974 TFA
|
Integrin
Autophagy
|
Cancer
|
|
Cilengitide is a potent and selective integrin inhibitor for αvβ3 and αvβ5 receptor, with IC50 values of 4 nM and 79 nM, respectively.
|
-
- HY-B0320A
-
-
- HY-N1415S
-
-
- HY-P1779A
-
|
β-Casomorphin-5 TFA
|
Opioid Receptor
|
Others
|
|
β-Casomorphin (1-5), bovine (TFA) is a peptide of bovine β-Casomorphin.
|
-
- HY-P2869E
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
β1-3,4,6 Galactosidase is a broad specificity exoglycosidase that catalyzes the hydrolysis of terminal, non-reducing β1-3 β1-4 and β1-6 linked galactose residues from oligosaccharides, with β1-6 linked galactose residues at a slower rate .
|
-
- HY-136868
-
|
3-Phenoxazone 7-(β-D-glucopyranoside),98%
|
Biochemical Assay Reagents
|
Others
|
|
Resorufin-β-D-glucopyranoside, 98% (3-Phenoxazone 7-(β-D-glucopyranoside), 98%) can be used to detect and quantify β-glucosidase activity in various biological samples.
|
-
- HY-W011654
-
|
4-Aminophenyl-beta-D-galactopyranoside, 98%
|
Biochemical Assay Reagents
|
Others
|
|
4-Aminophenyl-β-D-galactopyranoside, 98% is a biochemical reagent. 4-Aminophenyl-β-D-galactopyranoside, 98% is a substrate for β-galactosidase (HY-P2869) .
|
-
- HY-133708
-
|
1-O-Galloyl-β-D-glucose
|
Aldose Reductase
|
Metabolic Disease
|
|
β-Glucogallin is a potent and selective aldose reductase (AKR1B1) inhibitor. β-Glucogallin can be isolated from the medicinal plant Emblica officinalis .
|
-
- HY-133680
-
|
|
Tyrosinase
|
Metabolic Disease
|
|
β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol [2] [3].
|
-
- HY-163338
-
|
|
Beta-lactamase
|
Infection
|
|
Metallo-β-lactamase-IN-13 (Compound 13i) is a pan Metallo-β-Lactamase inhibitor. Metallo-β-lactamase-IN-13 provides broader coverage of metallo-β-lactamases expressing Gram-negative (GN) bacteria. Metallo-β-lactamase-IN-13 has antibacterial activity against P. aeruginosa .
|
-
- HY-149858
-
|
|
Wnt
|
Cancer
|
|
β-catenin-IN-7 (Compound 9) is a β-catenin inhibitor. β-catenin-IN-7 inhibits the interaction between β-catenin and Tcf-4, and inhibits Wnt-dependent target gene expression. β-catenin-IN-7 has anti-cancer activity .
|
-
- HY-W107585
-
-
- HY-P5946
-
-
- HY-113319
-
|
|
Endogenous Metabolite
|
Cancer
|
|
β-D-Fructose is a β-fruit sugar that can be produced by the hydrolysis of sucrose. β-D-Fructose can be used as a sweetness potentiator. β-D-Fructose can be designed as a units of antiproliferative agents against breast (MCF-7) and colon (MDST8) cancer cell lines .
|
-
- HY-105058A
-
|
14α/β-RU 24722
|
Others
|
Neurological Disease
|
|
14α/β-Vindeburnol (14α/β-RU 24722) a synthetic molecule derived from the eburnamine-vincamine alkaloid group, has many neuropsychopharmacological and antidepressant-like effects .
|
-
- HY-116771
-
|
|
Adrenergic Receptor
|
Metabolic Disease
|
|
CL316243 free acid is a highly potent selective β3-adrenoceptor agonist with a EC50 of 3 nM, but is an extremely poor to β1/2- receptors. CL316243 free acid is a effective stimulant of adipocyte lipolysis and increases brown adipose tissue thermogenesis and metabolic rate. CL316243 free acid has the potential for the treatment obesity, diabetes and urge urinary incontinence [2] [3].
|
-
- HY-116771A
-
|
|
Adrenergic Receptor
|
Metabolic Disease
|
|
CL316243 is a highly potent selective β3-adrenoceptor agonist with a EC50 of 3 nM, but is an extremely poor to β1/2- receptors .CL316243 is a effective stimulant of adipocyte lipolysis and increases brown adipose tissue thermogenesis and metabolic rate [2]. CL316243 has the potential for the treatment obesity, diabetes and urge urinary incontinence [3].
|
-
- HY-153637
-
|
|
Thyroid Hormone Receptor
|
Endocrinology
|
|
THR-β modulator-1 (compound 1a) is a potent thyroid hormone receptor β modulator. THR-β modulator-1 can be used in research of thyroid hormone receptor related disorders .
|
-
- HY-168087
-
|
|
Integrin
|
Cardiovascular Disease
|
|
GSK3335103 is an orally active, non-peptide αvβ6 integrin inhibitor (pIC50=8). GSK3335103 can be used in the study of pulmonary fibrosis .
|
-
- HY-149282
-
-
- HY-149281
-
-
- HY-N7682
-
|
|
Fungal
|
Others
|
|
β-Tomatine is a breakdown product of α-tomatine and a less fungitoxic compound. β-Tomatine can suppress plant defense responses .
|
-
- HY-137827
-
|
p-Nitrophenyl β-D-Cellobioside
|
Fluorescent Dye
|
Others
|
|
4-Nitrophenyl β-D-Cellobioside (p-Nitrophenyl β-D-cellobioside) is a cellotriose analog, a chromogenic substrate for the detection of cellulase activity. Exoglucanases, endoglucanases, and β-glucosidases hydrolyze 4-Nitrophenyl β-D-Cellobioside to yield p-nitrophenol (PNP) [2].
|
-
- HY-N0411R
-
|
|
Endogenous Metabolite
Apoptosis
Reactive Oxygen Species
|
Metabolic Disease
Cancer
|
|
β-Carotene (Standard) is the analytical standard of β-Carotene. This product is intended for research and analytical applications. β-Carotene (Provitamin A), a carotenoid compound, is a naturally-occurring vitamin A precursor. β-Carotene is a modulator of reactive oxygen species (ROS), with antioxidant and antiinflammatory activities. β-Carotene may serve as an antioxidant or as a prooxidant, depending on its intrinsic properties as well as on the redox potential of the biological environment in which it acts. β-Carotene induces breast cancer cells apoptosis, with anticancer activities [2] [3] .
|
-
- HY-P0117A
-
|
Tat-NR2bct TFA; NA-1 TFA
|
iGluR
NO Synthase
|
Neurological Disease
|
|
Tat-NR2B9c TFA (Tat-NR2Bct TFA) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c TFA disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC50 values of 0.5 μM and 8 μM, respectively. Tat-NR2B9c TFA also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy .
|
-
- HY-172171
-
|
|
GSK-3
β-catenin
|
Neurological Disease
|
|
GSK3β-IN-2 (Compound S01) is the inhibitor for GSK3β with an IC50 of 0.35 nM. GSK3β-IN-2 activates Wnt/β-catenin signaling pathway, promotes neurogenesis and neurite growth. GSK3β-IN-2 inhibits Aβ-induced tau hyperphosphorylation at Ser396, reduces the formation of neurofibrillary tangles. GSK3β-IN-2 ameliorates Alzheimer's Disease in zebrafish model .
|
-
- HY-114740
-
|
5,6-Benzoflavone; beta-NF
|
Aryl Hydrocarbon Receptor
Apoptosis
|
Neurological Disease
Cancer
|
|
β-Naphthoflavone is an exogenous aryl hydrocarbon receptor (AHR) ligand. β-Naphthoflavone can activate AHR to participate in various biological processes, including cell growth, differentiation, apoptosis, and metabolism. β-Naphthoflavone has antioxidant activity and can exert its antioxidant function by regulating the activity of antioxidant enzymes. β-Naphthoflavone is also a non-carcinogenic CYP1A inducer and can be used to treat aristolochic acid (AAI) induced renal injury [2] [3].
|
-
- HY-130842
-
|
β-NF-CH2-Br
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
β-Naphthoflavone-CH2-Br (β-NF-CH2-Br) is an arylhydrocarbon receptor (AhR) ligand. β-Naphthoflavone-CH2-Br can be used to synthesize the PROTAC β-NF-JQ1(HY-130256) .
|
-
- HY-N8214
-
|
|
Others
|
Cardiovascular Disease
|
|
Isorhamnetin 3-O-β-D-glucose-7-O-β-D-gentiobioside is a bioactive constituent that can be found in the seeds of Lepidium apetalum Willd. Isorhamnetin 3-O-β-D-glucose-7-O-β-D-gentiobioside exhibits significant triglyceride (TG)-lowering effects in HepG2 cells .
|
-
- HY-158977
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
β-Lactamase-IN-9 (compound 2) is a β-lactamase inhibitor that can restore the sensitivity of pathogens to β-lactam antibiotics .
|
-
- HY-W291131
-
|
IBT
|
HSV
Orthopoxvirus
|
Infection
|
|
Isatin-β-thiosemicarbazone is a potent anti-poxvirus agent (including monkeypox virus, orthopoxvirus, vaccinia virus, etc). Isatin-β-thiosemicarbazone also is a potent herpes simplex virus (HSV) inhibitor. Isatin-β-thiosemicarbazone exhibits
|
-
- HY-135577R
-
|
|
Drug Metabolite
|
Infection
|
|
β-Apooxytetracycline (Standard) is the analytical standard of β-Apooxytetracycline. This product is intended for research and analytical applications. β-Apooxytetracycline is a degradation product of Oxytetracycline (HY-B0275). Oxytetracycline is a widespread antibiotic .
|
-
- HY-N9521
-
|
|
Others
|
Cancer
|
|
3-O-β-D-Glucopyranosyl(1→2)-[a-Lrhamnopyranosyl(1→3)]-β-D-glucopyranosyl 28-O-β-D-glucuronopyranoside, a saponin, is isolated from Polaskia chichipe Backbg. 3-O-β-D-Glucopyranosyl(1→2)-[a-Lrhamnopyranosyl(1→3)]-β-D-glucopyranosyl 28-O-β-D-glucuronopyranoside shows ability to inhibit melanin biosynthesis by B16 melanoma cell with inhibitory activity 84.2% at 100μM[1].
|
-
![3-O-β-D-Glucopyranosyl(1→2)-[a-Lrhamnopyranosyl(1→3)]-β-D-glucopyranosyl 28-O-β-D-glucuronopyranoside](//file.medchemexpress.com/product_pic/hy-n9521.gif)
- HY-137249
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Resorufin-β-D-galactopyranoside is a commonly used substrate in various biochemical assays to measure the activity of β-galactosidase, an important enzyme involved in lactose metabolism and regulation of gene expression. Resorufin-β-D-galactopyranoside has unique chemical properties and can be hydrolyzed by β-galactosidase to form a red fluorescent product called resorufin. This makes it a useful tool for detecting and quantifying β-galactosidase activity in biological samples such as bacteria or mammalian cells.
|
-
- HY-18500
-
|
|
Drug Isomer
|
Others
|
|
(βS)-β-Hydroxy-L-histidine hydrochloride is a stereoisomer of β-hydroxyhistidine .
|
-
- HY-118614
-
|
|
Drug Metabolite
|
Neurological Disease
|
|
β-Nicotyrine is a metabolite of Nicotine.β-Nicotyrine, isolated from the leaves of Nicotiana tabacum plants and from cigarette smoke condensate, is a minor tobacco alkaloid .
|
-
- HY-N12378
-
|
|
Others
|
Inflammation/Immunology
|
|
β-Patchoulene is a tricyclic sesquiterpene isolated from the oil of Pogostemon cablin (patchouli oil). β-Patchoulene
can be used for the treatment of inflammatory diseases .
|
-
- HY-125773
-
|
beta-cyano-l-alanine
|
Endogenous Metabolite
|
Neurological Disease
|
|
β-cyano-L-Alanine (Beta-cyano-l-alanine), a nitrile of widespread occurrence in higher plants, is enzymatically produced by cyanoalanine synthase from cyanide and cysteine as substrates . β-cyano-L-Alanine abolishes the protective effect of ethanol on cerebral ischemia/reperfusion (I/R) injury [2].
|
-
- HY-N13329
-
|
|
Others
|
Others
|
|
Orcinol 1-O-beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside is a natural product .
|
-
- HY-W015084R
-
|
|
Apoptosis
|
Cancer
|
|
β-Ionone (Standard) is the analytical standard of β-Ionone. This product is intended for research and analytical applications. β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. Anti-cancer activity .
|
-
- HY-W744666
-
-
- HY-N3808
-
|
|
Others
|
Others
|
|
(4α,11β,15β)-11,15-Dihydroxykaur-16-en-19-oic acid is a compound isolated from the Tunisian Pulicaria laciniata (Coss.et Kral.) Thell. flowers .
|
-
- HY-N0378R
-
|
Mannitol(Standard); Mannite (Standard)
|
Endogenous Metabolite
Apoptosis
Adrenergic Receptor
PGC-1α
PKA
|
Cardiovascular Disease
Metabolic Disease
Cancer
|
|
D-Mannitol (Standard) is the analytical standard of D-Mannitol. This product is intended for research and analytical applications. D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β3-adrenergic receptor (β3-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells [2] [3] .
|
-
- HY-113024R
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
D-Mannitol (Standard) is the analytical standard of D-Mannitol. This product is intended for research and analytical applications. D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β3-adrenergic receptor (β3-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells [2] [3] .
|
-
- HY-141626S
-
-
- HY-N10867
-
|
|
Others
|
Others
|
|
β-Acids colupulone is the bitter substance. β-Acids colupulone can be isolated from hops .
|
-
- HY-N9443
-
|
|
Others
|
Others
|
|
(12β)-20-(β-D-Glucopyranosyloxy)-12-hydroxydammar-24-en-3-one is a natural product that can be found in Cladosporium microorganisms .
|
-
- HY-N1688
-
|
|
Others
|
Others
|
|
24-Norhopa-4(23),22(29)-diene-3β,6β-diol is a Triterpenoids product that can be isolated from the herbs of Dodonaea viscosa .
|
-
- HY-100563
-
|
|
Integrin
|
Cancer
|
|
Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.
|
-
- HY-100563A
-
|
|
Integrin
|
Cancer
|
|
Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.
|
-
- HY-144290
-
|
|
GSK-3
DYRK
|
Neurological Disease
|
|
ARN25068 is a sub-micromolar inhibitor of the three protein kinases, GSK-3β, FYN and DYRK1A to tackle tau hyperphosphorylation .
|
-
- HY-163896
-
|
|
β-catenin
|
Cancer
|
|
β-Catenin modulator-7 (Compound 5) is a modulator for β-catenin. β-Catenin modulator-7 inhibits the expression of β-catenin in HCT-116 cytoplasm and nucleus, suppresses the phosphorylation of GSK 3β. β-Catenin modulator-7 promotes NO release in HCT-116, and inhibits the proliferation of cancer cell HCT-116 with IC50 of 0.6-0.9 μM. β-Catenin modulator-7 can be used in reasearch about colon cancer .
|
-
- HY-P1502F
-
|
|
Opioid Receptor
|
Neurological Disease
|
|
Biocytin-β-endorphin, human is abiotinylated β-Endorphin, human (HY-P1502). β-Endorphin, human, a prominent endogenous peptide, existing in the hypophysis cerebri and hypothalamus, is an agonist of opioid receptor, with preferred affinity for μ-opioid receptor and δ-opioid receptor; β-Endorphin, human exhibits antinociception activity.
|
-
- HY-107201A
-
|
betadex hydrate
|
Biochemical Assay Reagents
|
Others
|
|
β-Cyclodextrin hydrate (Betadex hydrate) is a cyclic oligosaccharide composed of seven glucose units, featuring a hydrophobic central cavity and a hydrophilic outer surface. β-Cyclodextrin hydrate is utilized in an immunoassay method that leverages the complex formed by β-Cyclodextrin hydrate with small molecules to enhance the sensitivity of the immunodetection for these small molecules. β-Cyclodextrin hydrate is applicable for research in biosensing and immunoanalysis .
|
-
- HY-N6741
-
|
|
Others
|
Infection
Endocrinology
|
|
β-Zearalenol is a non-steroidal estrogenic mycotoxin synthesized by Fusarium species. β-Zearalenol potentially influences transcription and effects gene expression on translational level .
|
-
- HY-131405
-
|
|
Apoptosis
Bcl-2 Family
|
Cancer
|
|
β-Eleostearic acid is an apoptosis inducer with antiproliferative properties. β-Eleostearic acid down-regulates and up-regulates the mRNA levels of Bcl-2 and Bax, respectively .
|
-
- HY-136552
-
|
|
Others
|
Cancer
|
|
β-Bisabolene is a sesquiterpene isolated from opoponax (Commiphora guidotti). β-Bisabolene, an anti-cancer agent, can be used for the study of breast cancer .
|
-
- HY-N15410
-
|
|
Endogenous Metabolite
|
Others
|
|
β-Cotonefuran is a dibenzofuran phytoalexin produced by plants in response to biotic and abiotic stresses. β-Cotonefuran can be used in the study of Arabidopsis thaliana's response to salt stress .
|
-
- HY-A0252R
-
|
|
Adrenergic Receptor
|
Inflammation/Immunology
Cancer
|
|
Bupranolol (Standard) is the analytical standard of Bupranolol. This product is intended for research and analytical applications. Bupranolol is an orally active, competitive and non-selective β-adrenoceptor antagonist without intrinsic sympathomimetic activity .
|
-
- HY-N13497
-
|
|
Others
|
Others
|
|
3β,7β,19-Trihydroxy-25-methoxycucurbita-5,23-diene 7-O-glucoside is a triterpenoid product that can be isolated from Momordica charantia .
|
-
- HY-P1880
-
-
- HY-P1891
-
-
- HY-P1879
-
-
- HY-P1893
-
-
- HY-13951
-
-
- HY-20696R
-
|
|
5-HT Receptor
|
Metabolic Disease
|
|
Tetrahydro-β-carboline (Standard) is the analytical standard of Tetrahydro-β-carboline. This product is intended for research and analytical applications. Tetrahydro-β-carboline (Tryptoline) is a metabolite of tryptamine, also is a competitive serotonin reuptake inhibitor with an Ki value of 6.1 μM .
|
-
- HY-113478
-
|
Isoursodeoxycholic acid
|
Drug Metabolite
|
Metabolic Disease
|
|
3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) is a bile acid. 3β-Ursodeoxycholic acid shows good tolerance and well intestinal absorption by oral adminstation. 3β-Ursodeoxycholic acid can be isomerized by intestinal and hepatic enzymes to yield UDCA .
|
-
- HY-P3319
-
|
|
iGluR
|
Neurological Disease
|
|
β-Neuroprotectin is a (3H)TCP binding inhibitor with activity against NMDA-mediated neuronal cell death. β-Neuroprotectin can effectively inhibit the binding of [3H]TCP. β-Neuroprotectin provides neuroprotection at low concentrations against NMDA-induced neuronal cell death .
|
-
- HY-N1810
-
|
3α,6β-Ditigloyloxytropan-7β-ol
|
Others
|
Others
|
|
Ditigloylteloidine (3α,6β-Ditigloyloxytropan-7β-ol) is a Sesquiterpenoids product that can be isolated from the herbs of Eupatorium chinense var. tozanense. .
|
-
- HY-14679
-
|
|
GSK-3
|
Neurological Disease
|
|
GSK3β inhibitor II is an inhibitor of GSK3β. GSK3β inhibitor II can be used for research of Alzheimer’s disease (AD) .
|
-
- HY-P2803B
-
|
|
β-glucuronidase
|
Metabolic Disease
|
|
Beta-glucuronidase (helix pomatia) is a glycosyl hydrolase that hydrolyzes β-glucuronic acid and sulfate esters in urine and other biological fluids, and then releases β-glucuronate .
|
-
- HY-135670A
-
|
|
Glycosidase
|
Metabolic Disease
|
|
β-glycosidase-IN-1 (Compound 33) is a piperidine derivative and a β-glycosidase inhibitor. β-glycosidase-IN-1 has hypoglycemic activity .
|
-
- HY-N1415R
-
-
- HY-N13491
-
|
|
Others
|
Others
|
|
3β-Hydroxy-7β,25-dimethoxycucurbita-5,23-dien-19-al is a triterpenoid product that can be isolated from Momordica charantia .
|
-
- HY-N13525
-
|
|
Others
|
Others
|
|
Neochlorogenin6-O-β-D-xylopyranosyl-(1→3)-β-D-quinovopyranoside is a natural product .
|
-
- HY-N3995S
-
|
|
Apoptosis
Drug Metabolite
|
Cancer
|
|
5β-Dihydrocortisol-d6 is the deuterium labeled 5β-Dihydrocortisol. 5β-Dihydrocortisol, a metabolite of Cortisol, is a potential mineralocorticoid. 5β-Dihydrocortisol can potentiate glucocorticoid activity in raising the intraocular pressure. 5β-Dihydrocortisol causes breast cancer cell apoptosis[1][2][3][4][5].
|
-
- HY-169348
-
|
|
β-catenin
Wnt
c-Myc
|
Cancer
|
|
β-catenin-IN-8 (Compound 25) is a β-catenin inhibitor. β-catenin-IN-8 inhibits β-catenin and c-Myc protein levels, and inhibits Wnt-target genes level (Fgf20 and Sall4). β-catenin-IN-8 has colorectal cancer anticancer activities, and has metabolic stability .
|
-
- HY-156297
-
|
|
Proteasome
|
Inflammation/Immunology
|
|
β5i-IN-1 is a potent and selective inhibitor of β5i with a IC50 of 8.463 nM. β5i-IN-1 releases TNF-α and IL-6 and influences the transcriptional activity of NF-κB. β5i-IN-1 can be used in study idiopathic pulmonary fibrosis .
|
-
- HY-138111
-
|
p-Nitopheyl β-D-cellotetaoside
|
Fluorescent Dye
|
Others
|
|
4-Nitrophenyl β-D-cellotetraoside (p-Nitopheyl β-D-cellotetaoside) is a small molecule cellulose mimetic consisting of a tetramer of D-glucose units linked by β-1-4 glycosidic bonds. The fragmentation pattern of 4-Nitrophenyl β-D-cellotetraoside after enzymatic hydrolysis can be analyzed by TLC or by the release of 4-nitrophenol, which has a strong absorbance at 395 nm in alkaline solutions. 4-Nitrophenyl β-D-cellotetraoside can be used in cellulose degradation studies to determine the specificity of cellulases .
|
-
- HY-N2513R
-
|
|
Lipoxygenase
DNA/RNA Synthesis
|
Cancer
|
|
β-Boswellic acid (Standard) is the analytical standard of β-Boswellic acid. This product is intended for research and analytical applications. β-Boswellic acid is isolated from the gum resin of Boswellia serrata. β-Boswellic acid is a nonreducing-type inhibitor of the 5-lipoxygenase (5-LO) product formation either interacting directly with the 5-LO or blocking its translocation . β-Boswellic acid inhibits the synthesis of DNA, RNA and protein in human leukemia HL-60 cells [2].
|
-
- HY-156243
-
|
|
ROCK
|
Cancer
|
|
GDI2-IN-1 (compound (+)-37) is a GDP-dissociation inhibitor beta (GDI2) inhibitor with an IC50 of 2.87 μM and a KD of 36 μM. GDI2-IN-1 exhibits excellent in vivo antitumor activity in GDI2-overexpressing pancreatic xenograft models .
|
-
- HY-N8029
-
|
|
Others
|
Others
|
|
6-Hydroxyapigenin 6-O-β-D-glucoside-7-O-β-D-glucuronide (compound 8) is a kind of flavonoid. 6-Hydroxyapigenin 6-O-β-D-glucoside-7-O-β-D-glucuronide can be isolated from the water extract of Carthamus tinctorius .
|
-
- HY-136234
-
|
|
Endogenous Metabolite
|
Others
|
|
9-cis-β-Carotene, a precursor of retinal, is cleaved by beta-carotene oxygenase 1 (BCMO1) to produce 9-cis-retinal. 9-cis-β-Carotene inhibits photoreceptor degeneration and restores retinal function in vivo. 9-cis-β-Carotene has the potential for the study of congenital stationary night blindness and fundus albipunctatus .
|
-
- HY-P1047
-
|
[Pro18, Asp21] β-Amyloid (17-21)
|
Amyloid-β
|
Neurological Disease
|
|
β-Sheet Breaker Peptide iAβ5 is an effective brain amyloid-β (Abeta) degrader. Abeta deposits are associated with Alzheimer's disease (AD), and the related toxicity arises from its β-sheet conformation and aggregation. β-Sheet Breaker Peptide iAβ5 can repeatedly induce the degradation of fibrillary amyloid deposits in vivo. Therefore, β-Sheet Breaker Peptide iAβ5 can prevent and/or reverse neuronal contraction caused by Abeta and reduce the range of interleukin IL-1beta positive microglial-like cells around Abeta deposits. β-Sheet Breaker Peptide iAβ5 can reduce the size and/or number of brain amyloid plaques in AD. β-Sheet Breaker Peptide iAβ5 is labeled with a hydrophobic benzyl alcohol (HBA) tag and shows a bright blue color under acidic conditions, which can be used for quantitative determination.
|
-
- HY-P1962
-
|
[Asn670, Sta671, Val672]-Amyloid β Peptide (662-675)
|
Beta-secretase
|
Neurological Disease
|
|
β-Secretase inhibitor ([Asn670, Sta671, Val672]-Amyloid β Peptide (662-675)) is a β-secretase and BACE1 inhibitor (IC50: 25 nM for β-secretase) .
|
-
- HY-P1474A
-
|
Amyloid β-Protein (22-35) (TFA)
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid 22-35 (Amyloid β-Protein 22-35) TFA, the residues 22-35 fragment ofβ-amyloid protein, has a cytotoxic effect on cultured neurons from the rat hippocampus in serum-free medium. β-Amyloid 22-35 TFA forms aggregates and typical amyloid fibrils resembling those of the β-amyloid protein in neutral buffer solution) .
|
-
- HY-N15237
-
|
Allyl β-D-lactose
|
Biochemical Assay Reagents
|
Others
|
|
Allyl β-lactoside (Allyl β-D-lactose) is a lactoside, which can be generated by incubating lactose and allyl alcohol with cellulase preparation, and can be used as a starting material for the synthesis of glycopolymers .
|
-
- HY-156485S
-
-
- HY-130522
-
|
6β-PGI1
|
Prostaglandin Receptor
|
Others
|
|
6β-Prostaglandin I1 (6β-PGI1) is an analog of prostaglandin I2 (PGI2) that is resistant to hydrolysis in aqueous solutions. 6β-Prostaglandin I1 can reduce gastric acid secretion with an ID50 (dose causing 50% inhibition) of approximately 3.0 μg/kg/min (intravenous injection) .
|
-
- HY-P0179A
-
-
- HY-113068S
-
|
|
Isotope-Labeled Compounds
Tyrosinase
|
Metabolic Disease
|
|
β-Tocopherol-d3 is the deuterium labeled β-Tocopherol. β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol can also prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol[1][2][3].
|
-
- HY-133680S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
β-Tocopherol-d4 is a deuterium labeled β-Tocopherol (HY-133680). β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol .
|
-
- HY-N13444
-
|
|
Others
|
Others
|
|
10β-Hydroxycadina-4,11(13)-dien-12,8β-olide is a natural product .
|
-
- HY-P10037
-
|
|
Amyloid-β
|
Neurological Disease
|
|
β Amyloid(17-28) human is a β-amyloid peptide (Abeta), a lipid-induced amyloid core fragment. β Amyloid(17-28) human enhances aggregation of full-length β Amyloid40, producing toxic aggregates in Alzheimer's disease (AD) .
|
-
- HY-N0180R
-
|
|
Endogenous Metabolite
|
Inflammation/Immunology
Cancer
|
|
18β-Glycyrrhetinic acid (Standard) is the analytical standard of 18β-Glycyrrhetinic acid. This product is intended for research and analytical applications. 18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhiza uralensis and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.
|
-
- HY-W357154
-
|
4-Methylumbelliferyl beta-L-fucopyranoside
|
Biochemical Assay Reagents
|
Others
|
|
Methylumbelliferyl β-L-fucoside (4-Methylumbelliferyl beta-L-fucopyranoside) is a derivative of fucose that can be used in glycobiology research.
|
-
- HY-W039938
-
|
|
Fluorescent Dye
|
Others
|
|
4-Nitrophenyl β-D-xylopyranoside is a chromogenic β-xylosidase substrate. 4-Nitrophenyl β-D-xylopyranoside can be used to test β-xylosidase activity .
|
-
- HY-W013254
-
|
|
Glycosidase
|
Others
|
|
2-Nitrophenyl β-D-glucopyranoside is a substrate for β-glucosidase. 2-Nitrophenyl β-D-glucopyranoside can be used to test β-glucosidase activity [2].
|
-
- HY-N13142
-
|
|
Others
|
Inflammation/Immunology
|
|
Luteolin 7-O-[β-D-apiofuranosyl-(1→6)]-β-D-glucopyranoside (compound 3) is a flavonoid with antioxidant activity, which can be isolated from Margaritopsis carrascoana. Luteolin 7-O-[β-D-apiofuranosyl-(1→6)]-β-D-glucopyranoside has good DPPH free radical scavenging activity (IC50=0.188 mg/mL) .
|
-
![Luteolin 7-O-[β-D-apiofuranosyl-(1→6)]-β-D-glucopyranoside](//file.medchemexpress.com/product_pic/hy-n13142.gif)
- HY-N7907
-
|
|
Others
|
Metabolic Disease
|
|
Myricetin-3-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranoside is a natural product that can be obtained from sphaerophysa salsula. Myricetin-3-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranoside inhibits triglyceride (TG) accumulation in 3T3-L1 adipocytes [2].
|
-
- HY-59090
-
-
- HY-P0128A
-
|
Amyloid beta-peptide (25-35), HFIP-treated; Aβ25-35, HFIP-treated; β-Amyloid peptide (25-35), HFIP-treated
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (25-35) (Amyloid beta-peptide (25-35)), HFIP-treated is a β-Amyloid (25-35) (HY-P0128) treated with HFIP. β-Amyloid (25-35) (Amyloid beta-peptide (25-35)) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide, has shown neurotoxic activities in cultured cells .
|
-
- HY-132300A
-
|
|
β-catenin
|
Cancer
|
|
ZW4864 (free base) is an orally active and selective β catenin/B-Cell lymphoma 9 protein−protein interaction (β catenin/BCL9 PPI) inhibitor. ZW4864 (free base) inhibits β catenin/BCL9 PPI with a Ki value of 0.76 μM and an IC50 value of 0.87 μM .
|
-
- HY-P3966
-
-
- HY-P1787
-
|
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (4-10) is an epitope for the polyclonal anti-Aβ(1-42) antibody, reduces amyloid deposition in a transgenic Alzheimer disease mouse model .
|
-
- HY-W699926
-
|
(R)-Naproxen-β-D-glucuronide
|
Biochemical Assay Reagents
|
|
|
(R)-Naproxen acyl-β-D-glucuronide ((R)-Naproxen-β-D-glucuronide) is a compound metabolite with anti-inflammatory activity. (R)-Naproxen acyl-β-D-glucuronide can serve as a sensitive fluorescent substrate for proglutamyl peptidase 1, which produces a blue reaction after cleavage.
|
-
- HY-107045
-
|
|
Estrogen Receptor/ERR
|
Endocrinology
|
|
CHF 4227 free base is an orally active and selective estrogen receptor modulator (SERM) with high affinity to the human estrogen receptor-α and -β (Ki values of 0.017 nM and 0.099 nM, respectively) [2].
|
-
- HY-W008234
-
|
|
Biochemical Assay Reagents
|
Inflammation/Immunology
|
|
N-Phthaloyl-β-alanine (hapten FP) is an FX-type hapten without CH2S moiety. N-Phthaloyl-β-alanine can be coupled to OVA using the mixed anhydride method. N-Phthaloyl-β-alanine has more heterologies .
|
-
- HY-P2775
-
|
|
Glycosidase
|
Others
|
|
β-Glucosidase, almond is the rate-limiting enzyme of degradation of cellulose. β-Glucosidase is a major group among glycoside hydrolases. β-Glucosidase is involved in the degradation of cellulose in soils and has potential for monitoring biological soil quality [2] [3].
|
-
- HY-D1460
-
|
|
Bacterial
|
Infection
|
|
Fluorescein Di-β-D-Glucuronide, a fluorescent probe, can be utilized to non-invasively image the intestinal bacterial β-glucuronidase activity in nude mice. Fluorescein Di-β-D-Glucuronide-based imaging reveals the in vitro and in vivo activity of intestinal bacterial β-glucuronidase, which would facilitate pharmacodynamic studies of specific bacterial β-glucuronidase inhibitors in animal studies .
|
-
- HY-P1867
-
-
- HY-152057S
-
-
- HY-137783
-
-
- HY-N7635
-
|
β-D-Glucopyranosyl oleanolate
|
Others
|
Others
|
|
Oleanolic acid 28-O-β-D-glucopyranoside (β-D-Glucopyranosyl oleanolate) is a saponin isolated from the roots of Achyranthes bidentata Blume .
|
-
- HY-134353B
-
|
Adenosine 5'-β-thiodiphosphate (trilithium)
|
P2Y Receptor
NF-κB
|
Inflammation/Immunology
|
|
ADP-β-S trilithium is the trilithium salt form of ADP-β-S (HY-134353). ADP-β-S trilithium is the activator for P2Y12 receptor, which upregulates levels of IL-1βand IL-6 production in microglial cells, promotes the phosphorylation and nuclear translocation of NF-κB, and enhances the activation of the NLRP3 inflammasome .
|
-
- HY-137909
-
-
- HY-W150340
-
|
|
Galectin
Biochemical Assay Reagents
|
Cancer
|
|
β-Lactose is a disaccharide commonly found in milk and dairy products. It consists of two monosaccharides, glucose and galactose, linked by β-glycosidic bonds. β-Lactose has various applications in the food industry, especially as a sweetener and bulking agent. Furthermore, it can be used as a substrate for enzymes involved in lactose metabolism and as a model compound for studying carbohydrate-protein interactions.
|
-
- HY-W751152R
-
|
|
Others
|
Cancer
|
|
α,β-Thujone (Standard) is the analytical standard of α,β-Thujone. This product is intended for research and analytical applications. α,β-Thujone is a component of the essential oils of some plants. α,β-Thujone causes cancers in male rats and induces seizures in the highest doses .
|
-
- HY-P3489
-
|
|
Melanocortin Receptor
|
Endocrinology
|
|
β-Corticotropin (swine) is a synthetic form of the peptide hormone corticotropin (ACTH). β-Corticotropin stimulates steroid release [2].
|
-
- HY-N10493
-
-
- HY-66007
-
-
- HY-W041333
-
|
β-Phenyl-GABA hydrochloride; 4-Amino-3-phenylbutanoic acid hydrochloride; 4-Amino-3-phenylbutyric acid hydrochloride
|
GABA Receptor
|
Neurological Disease
|
|
Phenibut (β-Phenyl-GABA) hydrochloride is an orally active GABA-B agonist . Phenibut hydrochloride acts as a GABA-mimetic, primarily at GABAB?receptors. Phenibut hydrochloride has anxiolytic and nootropic (cognition enhancing) effects [2].
|
-
- HY-N6652R
-
|
|
Others
|
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
|
1-beta-D-Arabinofuranosyluracil (Standard) is the analytical standard of 1-beta-D-Arabinofuranosyluracil. This product is intended for research and analytical applications. 1-beta-D-Arabinofuranosyluracil (Uracil 1-β-D-arabinofuranoside) isolated from the Caribbean sponge Tectitethya crypta, is a methoxyadenosine derivative. 1-beta-D-Arabinofuranosyluracil has demonstrated a diverse bioactivity profile including anti-inflammatory activity, analgesic and vasodilation properties . 1-beta-D-Arabinofuranosyluracil reduces a proliferation of mouse lymphoma cells [2].
|
-
- HY-149136
-
|
|
Integrin
TGF-beta/Smad
|
Inflammation/Immunology
|
|
MORF-627 is a selective, orally active inhibitor for integrin αvβ6 with an IC50 of 9.2 nM measuring by human serum ligand binding assay. MORF-627 inhibits αvβ6-mediated TGF-β1 activation with an IC50 of 2.63 nM, inhibits SMAD2/3 phosphorylation with an IC50 of 8.3 nM. MORF-627 ameliorates the Bleomycin (HY-108345)-induced mouse lung fibrosis .
|
-
- HY-N12742
-
|
|
Others
|
Inflammation/Immunology
|
|
Tamarixetin 3-O-β-d-apiofuranosyl-(1 → 2)-β-d-galactopyranoside (compound 4) is an inhibitor of collagenase and elastase with potential anti-inflammatory activity. Tamarixetin 3-O-β-d-apiofuranosyl-(1 → 2)-β-d-galactopyranoside can be isolated from the methanol extract of the Balkan endemic species Astragalus thracicus Griseb .
|
-
- HY-P990078
-
|
LY3372993
|
Amyloid-β
|
Neurological Disease
|
|
Remternetug is a human immunoglobulin G1-kappa, anti-APP (amyloid beta A4 precursor protein) Aβ42 N3pGlu peptide monoclonal antibody. Remternetug recognizes a pyroglutamated form of Aβ. Remternetug results in rapid and robust amyloid plaque reduction. Remternetug can be used for Alzheimer's disease research [2].
|
-
- HY-137496
-
|
|
Biochemical Assay Reagents
|
|
|
4-Methylumbelliferyl β-D-mannopyranoside is a substrate that exhibits β-mannosidase activity. 4-Methylumbelliferyl β-D-mannopyranoside can be used to study β-mannosidase deficiency. The reactivity of 4-Methylumbelliferyl β-D-mannopyranoside shows different inhibitory effects on various substrates.
|
-
- HY-144316
-
|
|
Cholinesterase (ChE)
GSK-3
|
Neurological Disease
|
|
ZLWH-23 is a selective AChE inhibitor (IC50=0.27 μM) with GSK-3β inhibitory property (IC50=6.78 μM). ZLWH-23 possesses selectivity for AChE over BChE (IC50=20.82 μM) and for GSK-3β over multi-kinases. ZLWH-23 has the potential for the research of Alzheimer's disease .
|
-
- HY-117133
-
|
SF0166
|
Integrin
|
Metabolic Disease
|
|
Nesvategrast (SF0166) is a potent and selective αvβ3 antagonist with IC50 values of 0.6 nM, 8 nM, and 13 nM for αvβ3, αvβ6, and αvβ8, respectively. Nesvategrast inhibits cellular adhesion to vitronectin across human, rat, rabbit, and dog cell lines with IC50 values of 7.6 pM to 76 nM. Nesvategrast decreases neovascularization in the oxygen-induced retinopathy mouse model .
|
-
- HY-103512
-
|
|
GABA Receptor
|
Neurological Disease
|
|
TP003 is a non-selective benzodiazepine site agonist with EC50s of 20.3, 10.6, 3.24, 5.64 nM for α1β2γ2, α2β3γ2, α3β3γ2, α5β2γ2, respectively. TP003 induces anxiolysis via α2GABAA receptors .
|
-
- HY-144659
-
|
|
Beta-lactamase
Apoptosis
Bacterial
|
Infection
|
|
Metallo-β-lactamase-IN-5 (compound 5c) is a potent metallo-β-lactamases (MBL) inhibitor. Metallo-β-lactamase-IN-5 shows inhibitory activity against MBLs NDM-1 and VIM-1. Metallo-β-lactamase-IN-5 inhibits HUVECs with an IC50 of 45 μg/mL. Metallo-β-lactamase-IN-5 plus Imipenem exhibits synergistic antimicrobial activity .
|
-
- HY-129124
-
-
- HY-N1484
-
-
- HY-W001210
-
-
- HY-W738987
-
-
- HY-N13448
-
-
- HY-N2056
-
|
11-Keto-β-boswellic acid
|
Lipoxygenase
Leukotriene Receptor
NF-κB
|
Metabolic Disease
Cancer
|
|
11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production .
|
-
- HY-P4320
-
|
|
Integrin
|
Cancer
|
|
Cys-Arg-Gly-Asp-Phe-Pro-Ala-Ser-Ser-Cys (Disulfide bridge:cys1-cys10), a decapeptide containing a cyclic RGD active sequence, is an Integrin αIIbβ3 antagonist that inhibits platelet and Adhesion of proMMP-13 .
|
-
- HY-W145529
-
|
Gb4-beta-pNP
|
Biochemical Assay Reagents
|
Others
|
|
GalNAcβ(1-3)Galα(1-4)Galβ(1-4)Glc-β-pNP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-22306
-
|
Penta-O-acetyl-β-D-glucopyranose
|
Biochemical Assay Reagents
|
Metabolic Disease
|
|
β-D-Glucose Pentaacetate (Penta-O-acetyl-β-D-glucopyranose) is a glucose derivative, which is mainly used to explore the mechanism of insulin secretion .
|
-
- HY-N0338
-
|
|
Others
|
Others
|
|
(-)-Syringaresnol-4-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside is isolated from the bark of Albizia julibrissin .
|
-
- HY-141672S1
-
|
17β-Estradiol 3-sulfate-d4 sodium
|
GABA Receptor
|
Neurological Disease
|
|
17β-Estradiol sulfate-d4 (sodium) is the deuterium labeled 17β-Estradiol sulfate 17β-Estradiol sulfate (sodium), also known as β-Estradiol 3-sulfate sodium salt, is a neuroactive steroid[1][2].
|
-
- HY-W213592S
-
-
- HY-146996S
-
-
- HY-138112S
-
-
- HY-P1895
-
-
- HY-138112S2
-
-
- HY-138112S1
-
-
- HY-P1903
-
-
- HY-115872
-
-
- HY-P1898
-
-
- HY-113887S
-
-
- HY-146067
-
|
|
Fungal
Reactive Oxygen Species
|
Infection
|
|
β-Nor-lapachone is a Candida glabrata antibiofilm agent. β-Nor-lapachone can stimulate ROS production, inhibits efflux activity, adhesion, biofilm formation and the metabolism of mature biofilms of Candida glabrata. β-Nor-lapachone has antifungal activity .
|
-
- HY-P3513
-
|
|
ERK
MMP
|
Neurological Disease
|
|
β-Neo-Endorphin is an endogenous opioid peptide. β-Neo-Endorphin is a hypothalamic “big” Leu-enkephalin of porcine origin. β-Neo-Endorphin shows activation of the Erk1/2, MMP-2 and MMP-9 [2].
|
-
- HY-P3513A
-
|
|
ERK
MMP
|
Neurological Disease
|
|
β-Neo-Endorphin acetate is an endogenous opioid peptide. β-Neo-Endorphin acetate is a hypothalamic "big" Leu-enkephalin of porcine origin. β-Neo-Endorphin acetate shows activation of the Erk1/2, MMP-2 and MMP-9 [2].
|
-
- HY-B0452A
-
|
DU21220
|
Adrenergic Receptor
|
Endocrinology
|
|
Ritodrine (DU21220) is a potent and orally active β-adrenergic agonist. Ritodrine decreases preterm delivery and uterine contraction. Ritodrine has the potential for the research of preterm labor [2].
|
-
- HY-B0452
-
|
DU21220 hydrochloride
|
Adrenergic Receptor
|
Endocrinology
|
|
Ritodrine (DU21220) hydrochloride is a potent and orally active β-adrenergic agonist. Ritodrine hydrochloride decreases preterm delivery and uterine contraction. Ritodrine hydrochloride has the potential for the research of preterm labor [2].
|
-
- HY-159179
-
|
|
Integrin
|
Inflammation/Immunology
|
|
α4 integrin receptor antagonist 3 (Compound 11) is an orally active α4integrin receptor antagonist. α4 integrin receptor antagonist 3 can inhibit the adhesion of K562 cells mediated by the interaction between α4β1/VCAM-1 and α4β7/MAdCAM-1, with IC50 values of 130 nM and 2 nM, respectively. α4 integrin receptor antagonist 3 has the potential to be used in the study of dextran sulfate sodium (DSS) colitis mouse model .
|
-
- HY-164745
-
|
|
Fluorescent Dye
|
Others
|
|
L-β-ethynylserine (βES) is a threonine analog. L-β-ethynylserine is efficiently incorporated into newly synthesized proteins, and allows their selective visualization or enrichment through bioorthogonal ligation to fluorescent dyes or affinity tags,
respectively.
|
-
- HY-N11972
-
|
|
Others
|
Neurological Disease
|
|
β-Maaliene can be isolated from the fresh leaves of Vitex densiflora (Maaliene) and is the main component in the isolate. β-Maaliene can significantly reduce the exercise capacity of mice at certain doses .
|
-
- HY-N2924
-
-
- HY-10834
-
|
|
β-catenin
|
Cancer
|
|
β-catenin-IN-6 is a β-catenin inhibitor, targeting to canonical Wingless-related integration site signaling pathway. β-catenin-IN-6 inhibits human colorectal cancer cells proliferation, as well as in a β-catenin/RK3E mouse model [2].
|
-
- HY-19773
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
β-Lactamase-IN-1 is an inhibitor of β-Lactamase extracted from patent WO2016027249A1, page 77. β-Lactamase-IN-1 can be used to prepare of tricyclic nitrogen containing compound. β-Lactamase-IN-1 can be used for the research of neisseria gonorrhea infection .
|
-
- HY-N1814
-
|
11,12-Dehydroursolic acid lactone
|
Bacterial
|
Infection
|
|
3β-Hydroxyurs-11-en-28,13β-olide (11,12-Dehydroursolic acid lactone) is a triterpenoid that can be found in Fadogia tetraquetra var. tetraquetra . 3β-Hydroxyurs-11-en-28,13β-olide shows antibacterial activity .
|
-
- HY-W127769
-
|
Salmon-Gal
|
Fluorescent Dye
|
Others
|
|
Rose-β-D-Gal is a flurescent dye, is also a β-galactosidase substrate. Rose-β-D-Gal creates a pink/magenta color after the reaction and has been used for detection of β-gal activity [2].
|
-
- HY-W587733
-
-
- HY-P3793
-
|
|
Amyloid-β
|
Neurological Disease
|
|
Amyloid β-Protein (33-42) TFA is the residues 33-42 fragment of the β-amyloid protein. Amyloid β-Protein (33-42) TFA inhibits Aβ42-induced toxicity .
|
-
- HY-160266
-
-
- HY-P2046
-
|
|
Opioid Receptor
|
Neurological Disease
|
|
β-Endorphin (rat) is an endogenous opioid neuropeptide and peptide hormone. β-Endorphin (rat) has analgesic activity and also contributes to food intake in satiated rats. β-Endorphin (rat) can be used in the research of neurological diseases such as analgesia and drug addiction [2].
|
-
- HY-157161
-
|
|
11β-HSD
|
Cancer
|
|
11β-HSD2-IN-1 (compound CDSN) is a potent inhibitor of 11β-HSD2, inhibiting the metabolism of Cholestane-3β,5α,6β-triol (CT) in cells by 11β-HSD2 into the tumor promoter, carcinosterone. 11β-HSD2-IN-1 inhibits testosterone biosynthesis, thereby inhibiting MCF-7 cell proliferation. 11β-HSD2-IN-1 has immune activity and antiviral infection effects .
|
-
- HY-W145620
-
|
Gal[246Bn]beta(1-4)Glc[236Bn]-beta-MP
|
Biochemical Assay Reagents
|
Others
|
|
Gal[246Bn]β(1-4)Glc[236Bn]-β-MP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
![Gal[246Bn]β(1-4)Glc[236Bn]-β-MP](//file.medchemexpress.com/product_pic/hy-w145620.gif)
- HY-W145594
-
|
Gal[26bn]beta(1-4)glc[236bn]-beta-MP
|
Biochemical Assay Reagents
|
Others
|
|
Gal[26Bn]β(1-4)Glc[236Bn]-β-MP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
![Gal[26Bn]β(1-4)Glc[236Bn]-β-MP](//file.medchemexpress.com/product_pic/hy-w145594.gif)
- HY-125135
-
|
β-Peltatin
|
Drug Isomer
|
Cancer
|
|
(-)-β-Peltatin is an organic heterotetracyclic compound with antitumor activity and phytometabolite effects that are functionally related to α-peltatin .
|
-
- HY-N9258
-
|
|
Others
|
Others
|
|
p-Vinylphenyl O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside is a phenolic glycoside that can be isolated from the leaves of Viburnum furcatum .
|
-
- HY-P4894
-
-
- HY-P4892
-
-
- HY-P4883
-
-
- HY-P4884
-
-
- HY-P4887
-
-
- HY-W011410
-
|
p-Nitrophenyl β-D-Mannopyranoside
|
Glycosidase
|
Others
|
|
4-Nitrophenyl β-D-mannopyranoside is a useful substrate for β-D-mannopyranosidase. 4-Nitrophenyl β-D-mannopyranoside is also a substrate for GH1-glucosidase (EaBgl1A) and α-L-rhamnosidase [2] [3].
|
-
- HY-N2703
-
|
|
Glycosidase
|
Metabolic Disease
|
|
6β-Hydroxyipolamiide can be isolated from the methanolic extract of S. jamaicensis leaves. 6β-Hydroxyipolamiide has α-glucosidase inhibitory activity with an IC50 of 539.17 μg/mL .
|
-
- HY-N6740
-
|
|
Apoptosis
|
Metabolic Disease
|
|
Beta-Zearalenol is an mycotoxin produced by Fusarium spp, which causes apoptosis and oxidative stress in mammalian reproductive cells . Beta-Zearalenol is the derivative of zearalenone (ZEA) which can conjugate with glucuronic acid [2].
|
-
- HY-119963A
-
|
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
trans-β-terpineol, a monoterpenoid compound, can be isolated from the leaves of Schinus terebinthifolius. Terpineol has antioxidant and antibacterial activity. trans-β-terpineol is a bioactive compound that plays an antibacterial role in Schinus terebinthifolius .
|
-
- HY-122482
-
-
- HY-P1850
-
-
- HY-133179
-
-
- HY-P1510
-
-
- HY-P1517
-
-
- HY-151892S
-
-
- HY-N13402
-
|
|
Others
|
Others
|
|
Formononetin-8-C-beta-D-apiofuranosyl-(1->6)-O-beta-D-glucopyranoside is a natural product .
|
-
- HY-E70393A
-
|
|
Others
|
Metabolic Disease
|
|
Human Factor IXa Beta is composed of two polypeptide chains held together by disulfide bonds. Human Factor IXa Beta shows clotting activity .
|
-
- HY-139751
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
β-Lactamase-IN-4 is a β-lactamase inhibitor extracted from patent WO2013149121A1, compound 708. β-Lactamase-IN-4 can be used for the research of bacterial infections .
|
-
- HY-146075
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
β-Lactamase-IN-8 (compound 20) is a potent and oral bioavailable broad-spectrum cyclic boronate β-lactamase inhibitor. β-Lactamase-IN-8 can be used for researching antibacteria .
|
-
- HY-139779
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
β-Lactamase-IN-5 is a β-lactamase inhibitor extracted from patent WO2013149121A1, compound 720. β-Lactamase-IN-5 can be used for the research of bacterial infections .
|
-
- HY-163339
-
|
|
Beta-lactamase
|
Infection
|
|
Metallo-β-lactamase-IN-14 (Compound 17e) is a Metallo-β-Lactamase inhibitor. Metallo-β-lactamase-IN-14 shows inhibition activity against VIM-1 and VIM-2. Metallo-β-lactamase-IN-14 has antibacterial activity against Gram-negative (GN) bacteria and P. aeruginosa .
|
-
- HY-151166
-
|
|
Bacterial
|
Cancer
|
|
β-Glucuronidase-IN-2 is a potent E. coli β-glucuronidase inhibitor with an IC50 value of 0.24 μM, an Ki value of 1.09 μM. β-Glucuronidase-IN-2 shows antiproliferative activity. β-Glucuronidase-IN-2 has the potential for the research of anti-cancer and anti-inflammatory therapies .
|
-
- HY-N6740S
-
|
|
Isotope-Labeled Compounds
Apoptosis
|
Metabolic Disease
|
|
β-Zearalanol-d4 is a deuterium labeled Beta-Zearalanol (HY-N6740） . Beta-Zearalenol is an mycotoxin produced by Fusarium spp, which causes apoptosis and oxidative stress in mammalian reproductive cells [2]. Beta-Zearalenol is the derivative of zearalenone (ZEA) which can conjugate with glucuronic acid [3].
|
-
- HY-N0171
-
|
|
Apoptosis
Endogenous Metabolite
|
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
|
Beta-Sitosterol (purity>80%) includes β-sitosterol (≥80%), stigmasterol, campesterol and brassicasterol mainly. Beta-Sitosterol is a plant sterol. Beta-Sitosterol (purity>80%) interfere with multiple cell signaling pathways, including cell cycle, apoptosis, proliferation, survival, invasion, angiogenesis, metastasis and inflammation .
|
-
- HY-N8279
-
|
Endo-β-1,3-1,4-glucanase
|
Endogenous Metabolite
|
Metabolic Disease
|
|
β-1,3-1,4-Glucanase catalyzes the hydrolysis ofβ-glucan into low molecular weight glucose polymers, thus reducing the hydrophilicity and viscosity of chyme and eliminating the anti-nutritional negative effect. β-1,3-1,4-glucanase can improve feed intake, enhance animal production, regulate cecal microbiota and increase feed conversion ratio .
|
-
- HY-P10035
-
|
|
Amyloid-β
|
Neurological Disease
|
|
β Amyloid(28-35) human is a β-amyloid peptide (Abeta), a lipid-induced amyloid core fragment. β Amyloid oligomers are neurotoxic, and β Amyloid(28-35) human can interact with neuronal membranes, regulate secondary structure and neurotoxicity, and cause Alzheimer's disease. β Amyloid(28-35) human has anisotropic effects on the acidic phospholipid DPH, resulting in enhanced internal fluidity of lipid membrane bilayers .
|
-
- HY-W024698
-
-
- HY-113418
-
-
- HY-N7276A
-
-
- HY-P3004
-
|
Lyticase
|
Endogenous Metabolite
|
Others
|
|
Endo-1,3-β-glucanase specifically hydrolyzes β-1,3-glycosidic bonds randomly along the β-glucan chain, and the final product is mainly glucan oligosaccharide. Endo-1,3-β-glucanase is produced by a variety of fungi, is often used in biochemical studies .
|
-
- HY-N13555
-
|
|
Others
|
Others
|
|
(19R)-5β,19-Epoxy-19-methoxycucurbita-6,23-diene-3β,25-diol is a triterpenoid product that can be isolated from Momordica charantia .
|
-
- HY-P1378
-
|
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (1-43)(human) is more prone to aggregation and has higher toxic properties than the long-known Aβ1-42. β-Amyloid (1-43)(human) shows a correlation with both sAPPα and sAPPβ. β-Amyloid (1-43)(human) could be considered an added Alzheimer's disease (AD) biomarker together with the others already in use .
|
-
- HY-131108
-
|
L-β-Aspartyl-L-aspartic acid
|
Others
|
Others
|
|
β-Aspartylaspartic acid is a natural compound found in Asparagus (Asparagus officinalis) Shoots .
|
-
- HY-N8982
-
|
|
Others
|
Others
|
|
Heraclenol 3'-O-[beta-D-apiofuranosyl-(1-6)-beta-D-glucopyranoside] is a Coumarins product that can be isolated from the roots of Heracleum stenopterum .
|
-
![Heraclenol 3'-O-[beta-D-apiofuranosyl-(1-6)-beta-D-glucopyranoside]](//file.medchemexpress.com/product_pic/hy-n8982.gif)
- HY-N7945
-
|
|
Others
|
Inflammation/Immunology
|
|
6-Hydroxykaempferol 3-O-β-rutinoside-6-O-β-D-glucoside is a potent antioxidant that can be isolated from Carthamus tinctorius .
|
-
- HY-N5119
-
|
|
Others
|
Others
|
|
Kaempferol-3-O-(2''-O-β-D-glucopyl)-β-D-rutinoside is a natural glycoside that could be found in Camellia oleifera seeds .
|
-
- HY-N9802
-
|
|
Apoptosis
Bcl-2 Family
|
Cancer
|
|
n-Butyl-β-D-fructofuranoside could be isolated from kangaisan. n-Butyl-β-D-fructofuranoside induces apoptosis through the mitochondrial pathway. n-Butyl-β-D-fructofuranoside can be used for cancer research .
|
-
- HY-147651
-
|
|
β-catenin
|
Cancer
|
|
β-catenin-IN-4 (Compound 39) is a β-catenin inhibitor with a Ki of 0.64 μM. β-catenin-IN-4 reduces the protein expression levels of cyclin D1 and c-Myc .
|
-
- HY-P1053
-
-
- HY-126548
-
-
- HY-W345102
-
-
- HY-N6616
-
|
Pinocembrin-7-O-β-D-glucoside
|
Others
|
Others
|
|
Pinocembrin-7-O-β-D-glucopyranoside (Pinocembrin 7-O-β-D-Glucoside) is is a flavanone that enhances lipid peroxidation .
|
-
- HY-N9439
-
|
|
Endogenous Metabolite
|
Others
|
|
6-O-β-D-Galactopyranosyl-D-galactose, a disaccharide, is a part of the polysaccharide main chain with β-(1→6)-glycoside bonds with a side chain bonded to the main one by the β-(1→3) bond .
|
-
- HY-B1449
-
-
- HY-W357142
-
-
- HY-P1850A
-
|
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (1-20) acetate is the acetate form of β-Amyloid (1-20)，which consists of amino acids 1 to 20 of beta amyloid protein .
|
-
- HY-P5308
-
|
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (1-19) (acetate) is the acetate form of β-Amyloid (1-19)，which consists of amino acids 1 to 19 of beta amyloid protein .
|
-
- HY-114464S1
-
|
4-Androsten-11β-ol-3,17-dione-d7
|
Endogenous Metabolite
11β-HSD
|
Others
|
|
11-Beta-hydroxyandrostenedione-d7 is the deuterium labeled 11-Beta-hydroxyandrostenedione. 11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor [1][2]
|
-
- HY-114464S
-
|
4-Androsten-11β-ol-3,17-dione-d4
|
Isotope-Labeled Compounds
Endogenous Metabolite
11β-HSD
|
Endocrinology
|
|
11-Beta-hydroxyandrostenedione-d4 is the deuterium labeled 11-Beta-hydroxyandrostenedione. 11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor[1][2].
|
-
- HY-W127641R
-
|
|
Biochemical Assay Reagents
|
Others
|
|
β-Methylcholine (chloride) (Standard) is the analytical standard of β-Methylcholine (chloride). This product is intended for research and analytical applications. β-Methylcholine chloride is an organic compound containing choline and chloride ions. It is commonly used as a pharmacological research tool, especially in the study of acetylcholine receptors and signaling pathways. β-Methylcholine chloride has various applications in the pharmaceutical industry, especially as a standard reference material for the calibration of analytical instruments. In addition, it can be used in the production of other choline derivatives and as a precursor of neurotransmitters.
|
-
- HY-N1415
-
-
- HY-P3777
-
|
|
Potassium Channel
|
Neurological Disease
|
|
β-Bag cell peptide is a neuroactive peptide. β-Bag cell peptide elevates cyclic AMP levels in the bag cell neurons. β-Bag cell peptide decreases the amplitudes of the voltage-dependent potassium currents .
|
-
- HY-137261
-
|
|
Others
|
Metabolic Disease
|
|
UDP-β-D-glucose disodium is a the stereoisomer of UDP-α-D-glucose. UDP-β-D-glucose disodium is an oligosaccharide that can be used to synthesize glycoproteins and glycolipids. UDP-β-D-glucose disodium can be used as a substrate .
|
-
- HY-N10645
-
|
|
Others
|
Others
|
|
Rhamnocitrin 3-O-β-D-apiofuranosyl(1→2)-β-D-glucopyranoside is a flavonol O-glycoside, isolated from Astragali semen of leguminous plants .
|
-
- HY-P3860
-
-
- HY-169126
-
|
|
β-catenin
Wnt
|
Cancer
|
|
β-catenin modulator IIa-661 is a β-catenin modulator that modulates β-catenin activity and inhibits the activity of the Wnt/wingless (wg) signaling pathway. β-catenin modulator IIa-661 can be utilized in cancer research .
|
-
- HY-W145656S
-
-
- HY-W145553
-
|
|
Biochemical Assay Reagents
|
Others
|
|
GalNAcβ(1-3)GlcNAc-β-pNP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-168500
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
Metallo-β-lactamase-IN-16 (compound 18) is a sulfone containing metallo-β-lactamase inhibitor with an anti-bacterial activity. Metallo-β-lactamase-IN-16 inhibits NDM-1 (New Dehli metallo-β-lactamase-1), IMP-1 (imipenemase-1), VIM-1 (Verona integron-encoded metallo-β-lactamase), and VIM-2 with IC50 values of 0.16 nM, 0.23 nM, 0.31 nM and 1.0 nM, respectively .
|
-
- HY-W751152
-
|
|
GABA Receptor
|
Cancer
|
|
α,β-Thujone is a component of the essential oils of some plants. α,β-Thujone causes cancers in male rats and induces seizures in the highest doses .
|
-
- HY-N4034
-
|
|
Others
|
Others
|
|
Hopane-3β,22-diol (compound 74) is a hopane isolated from A. mariesii .
|
-
- HY-124265S
-
-
- HY-P4740
-
-
- HY-150693
-
|
|
Estrogen Receptor/ERR
|
Cancer
|
|
Estrogen receptor β antagonist 2 is a potent and selective estrogen receptor β (ERβ) antagonist with IC50s of 109.10, 0.63 µM for Erα and Erβ, respectively .
|
-
- HY-P1779
-
-
- HY-118161
-
|
beta-1-Adamantylaspartic acid
|
Biochemical Assay Reagents
|
Others
|
|
1-Adamantylaspartate is a newly developed β-β-1-imidopropionic acid used to synthesize the C-terminal octapeptide of the β subunit of human chorionic gonadotropin (hCG) and the hexadecapeptide of the α subunit of the insulin receptor (30-55) by conventional solution methods and solid phase methods, aiming to inhibit the formation of asparagine during the synthesis of asparagyl peptides. Studies have shown that β-β-1-imidopropionic acid is an effective protector of the β-carboxyl function of aspartic acid residues.
|
-
- HY-116970
-
-
- HY-N2075R
-
|
|
Others
|
Inflammation/Immunology
|
|
3-Acetyl-beta-boswellic acid (Standard) is the analytical standard of 3-Acetyl-beta-boswellic acid. This product is intended for research and analytical applications. 3-Acetyl-beta-boswellic acid is a boswellic acid isolated from Boswellia serrata gum resin .
|
-
- HY-P2869D
-
|
|
Others
|
Metabolic Disease
|
|
β1-3,6 Galactosidase, Xanthomonas manihotis is a highly specific exoglycosidase that catalyzes the hydrolysis of non-reducing terminal β1-3 and β1-6 linked galactose from complex carbohydrates and glycoproteins .
|
-
- HY-115543
-
|
|
β-catenin
|
Cancer
|
|
β-catenin-IN-37 is a selective β-Catenin/T-cell factor protein-protein interaction (β-catenin/Tcf PPI) inhibitor. β-catenin-IN-37 inhibits canonical Wnt signaling and the growth of colorectal cancer cells SW480 and HCT116 with the IC50 values of 20 μM and 31 μM, respectively .
|
-
- HY-144261
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
Metallo-β-lactamase-IN-3 (compound 35) is a potent metallo-β-lactamases (MBL) inhibitor. Metallo-β-lactamase-IN-3 shows high activity against VIM-1 and NDM-1, with IC50 of 0.6 and 1.0 μM, respectively. Metallo-β-lactamase-IN-3 does not show inhibition of IMP-7 .
|
-
- HY-P3841
-
|
|
PKC
|
Others
|
|
Protein Kinase C β Peptide is a peptide fragment of Protein Kinase Cβ. Protein Kinase Cβ is related with hyperglycemia decreases endothelium-derived nitric oxide. Inhibition of Protein kinase Cβ prevents the reduction in endothelium-dependent vasodilation induced by acute hyperglycemia .
|
-
- HY-N0181A
-
|
9β,10α-Ergosterol
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Lumisterol (9β,10α-Ergosterol), a steroid compound, is the (9β,10α)-stereoisomer of Ergosterol (HY-N0181). Lumisterol is a photoprotective agent against UVB-induced DNA damage and anti-proliferative activities .
|
-
- HY-N12983
-
|
|
Apoptosis
Bcl-2 Family
|
Cancer
|
|
β-Bourbonene is a kind of sesquiterpene. β-Bourbonene inhibits cell growth, and induces apoptosis and G0/G1 arrest of prostate cancer PC-3M cells .
|
-
- HY-N9981
-
|
|
Biochemical Assay Reagents
|
Cancer
|
|
5β-Hydroxybufotalin (compound 6) is an anticancer agent that can effectively inhibit the growth activity of cancer cells. 5β-Hydroxybufotalin is also a natural product obtained from the chinese traditional drug Ch'an Su .
|
-
- HY-N12035
-
|
|
Others
|
Cancer
|
|
Picropodophyllin-4-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside (compound 17) is a lignan isolated from the roots and rhizomes of Podophyllum sinensis .
|
-
- HY-12452
-
-
- HY-P3550
-
-
- HY-104076
-
-
- HY-107530
-
-
- HY-N13420
-
|
|
Others
|
Others
|
|
3beta-Acetoxy-11alpha,12alpha-epoxyoleanan-28,13beta-olide is a natural product .
|
-
- HY-136464
-
|
|
β-catenin
|
Cancer
|
|
β-catenin-IN-2 is a potent β-catenin inhibitor, compound H1B1, extracted from patent US20150374662A1. β-catenin-IN-2 can be used for the study of colorectal cancer .
|
-
- HY-124265S2
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
4β-Hydroxycholesterol-d4 is the deuterium labeled 4β-Hydroxycholesterol. 4β-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation[1][2].
|
-
- HY-160709
-
|
|
Wnt
β-catenin
|
Cancer
|
|
Wnt/β-catenin-IN-2 (Compound 3235-0367) is a Wnt/β-catenin signaling pathway inhibitor, with IC50 and KD values of 7.1 and 2.5 μM, respectively. Wnt/β-catenin-IN-2 can be used for the research of cancer .
|
-
- HY-P3185
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
beta-Galactose dehydrogenase can make conversion of galactose to galactonolactone and the concomitant reduction of NAD to the fluorescent NADH. beta-Galactose dehydrogenase can be used for the determination of galactose .
|
-
- HY-W011063
-
|
|
Cathepsin
|
Metabolic Disease
|
|
Gly-Phe-β-naphthylamide is the substrate of Cathepsin C. Gly-Phe-β-naphthylamide can be used to study intralysosomal hydrolysis, lysosomal membrane permeability, and the function of cathepsin C .
|
-
- HY-Y1801
-
|
L-Aspartic acid β-methyl ester hydrochloride
|
Amino Acid Derivatives
|
Others
|
|
β-Methyl L-aspartate hydrochloride is an aspartic acid derivative .
|
-
- HY-P4867
-
|
|
Amyloid-β
|
Others
|
|
β Amyloid (1-42) (scrambled) is acontrol of β-Amyloid (1-42), human TFA (HY-P1363).
|
-
- HY-169569
-
|
|
β-catenin
|
Cancer
|
|
β-Catenin modulator-8 (Compound Ⅸa) is a β-Catenin modulator and can be used for cancer research .
|
-
- HY-N9169
-
|
|
Others
|
Others
|
|
8β-(4-Hydroxytigloyloxy)ovatifolin is a Sesquiterpenoids product that can be isolated from the herbs of Eupatorium glehni .
|
-
- HY-153678
-
|
|
β-catenin
|
Cancer
|
|
β-Catenin modulator-1 (IIa-650) is a β-Catenin modulator useful in cancer research .
|
-
- HY-138943
-
|
5'-O-β-D-galactosyl-5-fluorouridine
|
Drug Intermediate
|
Cancer
|
|
5-Fluorouridine 5'-O-β-D-galactopyranoside (5'-O-β-D-galactosyl-5-fluorouridine) is a 5-Fluorouridine proagent. 5-Fluorouridine 5'-O-β-D-galactopyranoside can be converted by the enzyme β-D-galactosidase to the potent antineoplastic agent 5-Fluorouridine .
|
-
- HY-E70046
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
beta-1,4-Galactosyltransferase (LgtB) (EC 2.4.1.90) (B4GALT1 (LgtB)) is often used in biochemical studies. beta-1,4-Galactosyltransferase (LgtB) catalyzes the reaction involving UDP-galactose and N-acetylglucosamine for the production of galactose beta-1,4-N-acetylglucosamine .
|
-
- HY-130214
-
-
- HY-P2869B
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
β1-4 Galactosidase, E. coli is a highly specific exoglycosidase that catalyzes the hydrolysis of terminal, non-reducing β1-4 linked galactose residues from oligosaccharides .
|
-
- HY-N2923
-
-
- HY-W043333
-
-
- HY-U00325
-
|
|
11β-HSD
|
Neurological Disease
|
|
11β-HSD1-IN-1 is an inhibitor of 11β-hydroxydehydrogenase 1 (11β-HSD1), with an IC50 of 52 nM, and used for the treatment of pain.
|
-
- HY-137550
-
|
|
Biochemical Assay Reagents
|
Others
|
|
4-Nitrophenyl β-D-galactopyranoside is a derivative of beta-D-galactoside and monosaccharide. 4-Nitrophenyl β-D-galactopyranoside can be used for affinity label .
|
-
- HY-153701
-
|
|
JAK
|
Cancer
|
|
JAK-IN-26 (compound 2) is an orally active JAK inhibitor with good pharmacokinetic characteristics. JAK-IN-26 inhibits IFN-α2B-induced phosphorylation of STAT3 in Jurkat cells (IC50=17.2 nM) .
|
-
- HY-101532
-
|
β-CDN3; 6A-deoxy-6A-azido-β-cyclodextrin
|
Biochemical Assay Reagents
|
Others
|
|
6A-Azido-6A-deoxy-β-cyclodextrin (β-CDN3; 6A-deoxy-6A-azido-β-cyclodextrin) is a new water-soluble Schiff base ligand based on β-cyclodextrin (HY-107201). 6a-Azido-6a-deoxy-β-cyclodextrin can be used for biaqueous hydroformylation. β-cyclodextrin (βCD) has a unique affinity for Dexamethasone (HY-14648), and can be used as a topical osmotic enhancer to introduce it into the agent carrier system [2]. 6A-Azido-6A-deoxy-β-cyclodextrin is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-113914
-
|
Elraglusib
|
GSK-3
Apoptosis
Autophagy
|
Cancer
|
|
9-ING-41 (Elraglusib) is a maleimide-based ATP-competitive and selective glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 of 0.71 μM. 9-ING-41 significantly leads to cell cycle arrest, autophagy and apoptosis in cancer cells. 9-ING-41 has anticancer activity and has the potential for enhancing the antitumor effects of chemotherapeutic agents [2] [3] .
|
-
- HY-15927
-
|
|
Biochemical Assay Reagents
|
Metabolic Disease
|
|
4-Nitrophenyl β-D-glucopyranoside is a chromogenic substrate for β-glucosidase. 4-Nitrophenyl β-D-glucopyranoside is converted to a colored product, p-nitrophenol that is easily detected spectrophotometrically at 405 nm when used in a β-glycosidase assay. 4-Nitrophenyl β-D-glucopyranoside is hydrolysed through intramolecular nucleophilic catalysis by the phosphate group in the 2-position. 4-Nitrophenyl β-D-glucopyranoside is promising for research of postmenopausal osteoporosis [2] [3].
|
-
- HY-W011792R
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Diacetone-β-D-fructose (Standard) is the analytical standard of Diacetone-β-D-fructose. This product is intended for research and analytical applications. Diacetone-β-D-fructose is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
|
-
- HY-D1224
-
|
|
Fluorescent Dye
|
Others
|
|
Chlorophenol red-β-D-galactopyranoside is a long-wavelength dye, which has been widely used for colorimetric assays. Chlorophenol red-β-D-galactopyranoside is also a β-galactosidase substrate commonly used in recombinant yeast oestrogenic assays [2].
|
-
- HY-115419
-
|
|
Liposome
|
Others
|
|
1-Thio-β-D-glucose sodium is the sodium salt form of 1-Thio-β-D-glucose. 1-Thio-β-D-glucose forms hydrophilic self-assembled monolayer with metal, stablizes the lipid bilayer and protects the proteins from denaturation .
|
-
- HY-D1510
-
|
|
Biochemical Assay Reagents
|
Others
|
|
4-Nitrophenyl 2-O-(β-L-Fucopyranosyl)-β-D-Galactopyranoside is a synthetic chromogenic substrate and can be used in the assay of α-fucosidases which hydrolyze the glycosidic linkage Fuc α1-2Gal. The assay is based on the sequential action of α-fucosidase and an exogenously added exo-β-d-galactosidase to release the easily measurable p-nitrophenol moiety .
|
-
- HY-P1286
-
-
- HY-W141960
-
-
- HY-E70078
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Cystathionine β-synthase is an enzyme that catalyzes the condensation of serine and homocysteine to water and cystathionine. Cystathionine β-synthase is a prominent enzyme for the production of hydrogen sulfide (H2S) .
|
-
- HY-113482S
-
-
- HY-W587978
-
-
- HY-152805
-
|
|
Nucleoside Antimetabolite/Analog
|
Others
|
|
9-(2-β-C-Methyl-β-D-ribofuranosyl)purine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
|
-
- HY-169472
-
|
|
Drug Derivative
|
Cardiovascular Disease
|
|
11-Deoxy prostaglandin F1β is a synthetic analog of PGF1β. 11-Deoxy prostaglandin F1β exhibits vasodepressor and bronchodilator activities in guinea pigs .
|
-
- HY-138244
-
-
- HY-P2551
-
|
|
Amyloid-β
|
Neurological Disease
|
|
Biotin-β-Amyloid (17-40) is a N-terminal-labelled biotinylated amyloid-?-(1-40) peptide. β-Amyloid (17-40) is a 24-residue fragment of the Aβ protein via?post-translational processing of amyloid precursor protein (APP) .
|
-
- HY-D0935
-
|
|
Fluorescent Dye
|
Others
|
|
4-Methylumbelliferyl-β-D-glucuronide is a fluorogenic substrat (λex=362 nm, λem=445 nm). 4-Methylumbelliferyl-β-D-glucuronide has potential applications in detecting the activity of β-glucuronidase and the number of Escherichia coli [2] [3].
|
-
- HY-N5152
-
|
|
Others
|
Cancer
|
(2′S)-4′-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranosylvisamminol is a chromone Glycoside that could be isolated from Roots of Saposhnikovia divaricate. (2′S)-4′-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranosylvisamminol exhibits weak anti-cancer activity in human cancer cell lines .
|
-
- HY-W283359
-
|
|
Fluorescent Dye
|
Others
|
|
4-Methylumbelliferyl β-D-ribofuranoside is a fluorogenic substrate of β-ribosidase .
|
-
- HY-147055
-
-
- HY-155504
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
Metallo-β-lactamase-IN-11 (compound 5f) is a Metallo-β-lactamases (MBLs) inhibitor, potent against bacterial metallophyllactamase CphA (IC50=45 µM). Metallo-β-lactamase-IN-11 (10 µM) inhibits NDM-1 by 49% and AIM-1 by 61%. Metallo-β-lactamase-IN-11 can be used in the research of inhibiting antibiotic resistance .
|
-
- HY-116055
-
|
3-O-β-D-Galactopyranosyl-sn-glycerol
|
Biochemical Assay Reagents
|
Others
|
|
(2R)-Glycerol-O-β-D-galactopyranoside (3-O-β-D-Galactopyranosyl-sn-glycerol) is a good substrate for all three components of the lac operon, i.e. β-galactosidase, the lactose transporter and thiogalactoside transacetylase .
|
-
- HY-P1362A
-
|
Amyloid β Peptide (42-1)(human) TFA
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (42-1), human TFA is the inactive form of Amyloid β Peptide (1-42). β-Amyloid (42-1), human TFA is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease .
|
-
- HY-145381
-
|
|
11β-HSD
|
Metabolic Disease
|
|
11β-HSD1-IN-6 is a an 11β-HSD-1 inhibitor. The 11β hydroxysteroid dehydrogenase enzymes (11β-HSDs) mediate the interconversion of the glucocorticoid (GC) corticosterone or cortisol to an inactive form, 11-dehydrocorticosterone (11-DHC) or Cortisone, respectively .
|
-
- HY-107201
-
|
betadex
|
Influenza Virus
|
Infection
|
|
β-Cyclodextrin is a cyclic polysaccharide composed of seven units of glucose (α-D-glucopyranose) linked by α-(1,4) type bonds. β-Cyclodextrin has often been used to enhance the solubility of agents. β-Cyclodextrin has anti-influenza virus H1N1 activities.
|
-
- HY-138795
-
|
|
Endogenous Metabolite
|
Cancer
|
|
Curcumin-β-D-glucuronide is a major metabolite after oral intake of Curcumin in hepatic tissue and portal blood. Curcumin-β-D-glucuronide can be used for the research of colon cancer [2].
|
-
- HY-144513
-
|
|
Bacterial
|
Infection
|
|
Stigmastan-3β-ol is a sterol that can be isolated from Tinospora sinensis and Ginkgo biloba L.. Stigmastan-3β-ol has antimicrobial activity [2].
|
-
- HY-18644
-
CWHM-12
5 Publications Verification
|
Integrin
|
Cancer
|
|
CWHM-12 is a potent inhibitor of αV integrins with IC50s of 0.2, 0.8, 1.5, and 1.8 nM for αvβ8, αvβ3, αvβ6, and αvβ1.
|
-
- HY-P1468F1
-
|
5-FAM-Amyloid β-protein (1-28)
|
Amyloid-β
|
Others
|
|
5-FAM-β-Amyloid (1-28) is afluorescently labeled β-Amyloid (1-28) (HY-P1468).
|
-
- HY-124265S1
-
-
- HY-W324243
-
|
|
11β-HSD
|
Metabolic Disease
|
|
11β-HSD1-IN-9 (compound c4a) is a potent 11β-HSD1 inhibitor with IC50 values of 0.48 and 1.3 µM for human and murine 11β-HSD1, respectively. 11β-HSD1-IN-9 competitively interacts with rat 11β-HSD1. 11β-HSD1-IN-19 can be used in studies of obesity, hyperglycemia and cognitive impairment .
|
-
- HY-149728
-
-
- HY-N12095
-
|
|
Others
|
Others
|
|
Chavicol β-D-glucoside is a phenylpropanoid heteroside. Chavicol β-D-glucoside can be isolated from subspecies of Cedronella canariensis .
|
-
- HY-W768883
-
-
- HY-N7401
-
|
|
Complement System
|
Others
|
|
Entadamide-A-β-D-glucopyranoside is one of the major components in the seeds of Entada phaseoloides. Entadamide-A-β-D-glucopyranoside has anti-complement activitie .
|
-
- HY-E70113
-
-
- HY-117215A
-
|
|
Others
|
Others
|
|
trans-β-Ocimene is a compound that can be isolated from Melaleuca viridiflora .
|
-
- HY-N9751
-
|
|
Others
|
Others
|
|
β-Guaiene is a sesquiterpene, which can be used for perfuming and flavoring .
|
-
- HY-P10040
-
|
|
Amyloid-β
|
Neurological Disease
|
|
(Gln22)β-Amyloid (1-40) human is an amyloid beta protein (Aβ)-containing peptide used in Alzheimer's disease research .
|
-
- HY-153477
-
-
- HY-153196
-
|
|
ADC Linker
|
Others
|
|
Tetra-O-acetyl-β-D-galactopyranosyl-Ph-CH2-(4-nitrophenyl)carbonate-Fmoc (Example 2.28.6) is an ADC linker that can be used to synthesize antibody-conjugated active molecules (ADCs) .
|
-
- HY-N0343A
-
|
p-Formylphenyl-β-D-glucopyranoside; p-Hydroxybenzaldehyde glucoside
|
Others
|
Others
|
|
4-Formylpyrnyl-β-D-glucopyranoside (p-Formylphenyl-β-D-glucopyranoside) is a metabolite of Gastrodin (HY-N0115) in rat plasma. 4-Formylpyrnyl-β-D-glucopyranoside can be used to study the effects of multiple doses and food on the pharmacokinetic behavior of oral Gastrodin and its metabolites .
|
-
- HY-N11678
-
|
DON-3-β-D-glucoside; Deoxynivalenol 3-glucoside
|
Drug Metabolite
|
Metabolic Disease
|
|
Deoxynivalenol-3-β-D-glucoside (DON-3-β-D-glucoside) is a plant metabolite of the Fusarium mycotoxin Deoxynivalenol (HY-N6684). Deoxynivalenol-3-β-D-glucoside exhibits lower toxicity than Deoxynivalenol in vitro and in vivo [2].
|
-
- HY-152817
-
|
|
Nucleoside Antimetabolite/Analog
|
Others
|
|
2′-β-C-Methyl-beta-D-6-methylpurine riboside is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
|
-
- HY-124324
-
|
p-Nitopheyl β-D-cellotioside
|
Fluorescent Dye
|
Others
|
|
4-Nitrophenyl β-D-cellotrioside (p-Nitopheyl β-D-cellotioside) is a chromogenic substrate for endoglucanases and cellulose biohydrolases. As a fluorescent dye, nitrophenyl β-D-Cellotrioside can be hydrolyzed by enzymes to release 4-nitrophenol, producing a yellow color. The activity of the enzyme can be quantitatively analyzed by monitoring the change in absorbance at 405 nm .
|
-
- HY-P1378A
-
|
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (1-43)(human) TFA is more prone to aggregation and has higher toxic properties than the long-known Aβ1-42. β-Amyloid (1-43)(human) TFA shows a correlation with both sAPPα and sAPPβ. β-Amyloid (1-43)(human) TFA could be considered an added Alzheimer's disease (AD) biomarker together with the others already in use .
|
-
- HY-160618
-
|
|
11β-HSD
|
Metabolic Disease
|
|
11β-HSD2-IN-2 (compound 3) is a selective inhibitor for 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) with an IC50 of 300 nM .
|
-
- HY-136960
-
|
|
Adrenergic Receptor
|
Others
|
|
β2AR antagonist 1 (Cmpd-15PA) is an antagonist of β2 adrenergic receptor (β2AR). β2AR antagonist 1 binds to the intracellular surface of the β2AR .
|
-
- HY-157990
-
|
|
Wnt
β-catenin
|
Cancer
|
|
Wnt/β-catenin-in-1 (compounds 17) is a Wnt/β-catenin signaling pathway inhibitor. Wnt/β-catenin-IN-1 can induce apoptosis of colon cancer cells, has broad-spectrum anticancer activity, and can be used for the reseach of a variety of solid tumors .
|
-
- HY-N6851
-
|
Glycyrrhetic acid 3-O-mono-β-D-glucuronide; 3-monoglucuronyl-glycyrrhetinic acid
|
Others
|
Inflammation/Immunology
|
|
Glycyrrhetic acid 3-O-β-D-glucuronide, isolated from glycyrrhiza, is an important derivative of glycyrrhizin (GL) with an anti -allergic activity . Glycyrrhetic acid 3-O-β-D-glucuronide (GAMG) shows that β-glucuronidases (β-GUS) are key GAMG-producing enzymes, displaying a high potential to convert GL directly into GAMG [2].Glycyrrhetic acid 3-O-β-D-glucuronide is valuable as a sweetener.
|
-
- HY-135114
-
|
HPCD
|
SARS-CoV
|
Infection
Inflammation/Immunology
|
Hydroxypropyl-beta-cyclodextrin is a SARS-CoV-2 inhibitor. Hydroxypropyl-beta-cyclodextrin has immunomodulatory effects, which can reduce the production of inflammatory cytokines in lung epithelial cells infected by the virus .
|
-
- HY-124957
-
|
|
Cholinesterase (ChE)
Apoptosis
|
Cancer
|
|
β-NETA is a potent and noncompetitive choline acetyltransferase (ChA; IC50=76 μM) and cholinesterase (ChE; IC50=40 μM) inhibitor. β-NETA weakly inhibits acetylcholinesterase (AChE; IC50=1 mM) [2].
|
-
- HY-N8934
-
|
|
Others
|
Cancer
|
|
6β-Hydroxytomentosin, a sesquiterpenoid, can be found in flowers of Inula japonica. 6β-Hydroxytomentosin exhibits weak cytotoxicities against A549, SK-OV-3, HepG-2 and HT-29 cell lines [2].
|
-
- HY-123012
-
|
LY-488756
|
Adrenergic Receptor
|
Others
|
|
Lubabegron is a potent modulator of β-adrenergic receptor (β -AR). Lubabegron demonstrates antagonistic behavior at the β1 and β 2 receptor subtypes and agonistic behavior at the β 3 receptor subtype in cattle. Lubabegron reduces NH3 gas emissions from an animal or its waste .
|
-
- HY-148524
-
|
|
mAChR
Adrenergic Receptor
|
Cardiovascular Disease
|
|
β2AR/M-receptor agonist-1 (example 131) is a muscarinic antagonist and β2 adrenoceptor agonist (MABA). β2AR/M-receptor agonist-1 shows potency to β2 adrenoceptor with an EC50 value of 9.2 nM. β2AR/M-receptor agonist-1 also has potency to muscarinic receptor with a Ki value of 30.2 nM. β2AR/M-receptor agonist-1 shows MABA potency with an EC50 value of 4.0 nM .
|
-
- HY-145433
-
|
|
17β-HSD
|
Cancer
|
|
17β-HSD1-IN-1 (Compound 1) is a highly selective 17β-HSD1 inhibitor with IC50s of 5.6 and 3155 nM for 17β-HSD1 and 17β-HSD2, respectively. 17β-HSD1-IN-1 can be used for the research of non-small cell lung cancer (NSCLC) .
|
-
- HY-N13705
-
|
|
Others
|
Others
|
|
3β,7β-Dihydroxy-11,15,23-trioxo-lanost-8,16-dien-26-oic acid is a triterpene compound that can be found in Ganoderma lucidum .
|
-
- HY-126304
-
|
|
Phosphatase
Endogenous Metabolite
ERK
|
Metabolic Disease
|
|
β-Glycerophosphate disodium salt pentahydrate is a bioactive endogenous metabolite and a phosphatase inhibitor. β-Glycerophosphate disodium salt pentahydrate plays an important role in inducing and maintaining osteoblast differentiation, mineral metabolism and signal transduction, and can be used as a drug carrier to form heat-sensitive hydrogels. β-Glycerophosphate disodium salt hydrate accelerates the calcification of vascular smooth muscle cells [2] [3].
|
-
- HY-130269
-
|
β-NF-CH2-OH
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
β-Naphthoflavone-CH2-OH (β-NF-CH2-OH) is a ligand for arylhydrocarbon receptor (AhR) E3 ligase. β-Naphthoflavone-CH2-OH can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs (e.g., β-naphthoflavone-JQ1) that recruit the AhR E3 ligase complex by incorporating AhR ligands into chimeric molecules. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins .
|
-
- HY-W145559
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Gal[236Bn]β(1-4)Glc[236Bn]-β-MP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
![Gal[236Bn]β(1-4)Glc[236Bn]-β-MP](//file.medchemexpress.com/product_pic/hy-w145559.gif)
- HY-164568
-
|
|
Drug Derivative
|
Cancer
|
|
7β,16α-Dihydroxybufalin is a dihydroxylated derivative of bufalin, which exhibits cytotoxicities against cancer cell lines [2].
|
-
- HY-P0128F
-
-
- HY-153682
-
|
|
β-catenin
|
Cancer
|
|
β-Catenin modulator-5 (compound IIa-84), an oxazole and thiazole compound, is a potent and selective β-Catenin modulator .
|
-
- HY-153680
-
|
|
β-catenin
|
Cancer
|
|
β-Catenin modulator-3 (compound IIa-112), an oxazole and thiazole compound, is a potent and selective β-Catenin modulator .
|
-
- HY-153681
-
|
|
β-catenin
|
Cancer
|
|
β-Catenin modulator-4 (compound IIa-92), an oxazole and thiazole compound, is a potent and selective β-Catenin modulator .
|
-
- HY-153679
-
|
|
β-catenin
|
Cancer
|
|
β-Catenin modulator-2 (compound IIa-130), an oxazole and thiazole compound, is a potent and selective β-Catenin modulator .
|
-
- HY-158453
-
|
FA2b N-linked oligosaccharide, 2-AA labelled; G0F with bisecting GlcNAc, 2-AA labelled
|
Biochemical Assay Reagents
|
Others
|
|
FA2B glycan (G0B), 2-AA labelled (FA2B N-linked oligosaccharide, 2-AA labelled; G0F with bisecting GlcNAc, 2-AA labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .
|
-
- HY-P3688
-
|
Aβ (1-38); Aβ38
|
Amyloid-β
|
Others
|
|
β-Amyloid (1-38) (Aβ (1-38); Aβ38) is aAβ Fragment.
|
-
- HY-113245
-
|
|
Endogenous Metabolite
|
Others
|
|
3-Indolyl-β-D-glucuronide, a chromogenic substrate for β-D-glucuronidase, employs in the detection and enumeration of E. coli, yielding a blue precipitate upon cleavage. 3-Indolyl-β-D-glucuronide in? patients' plasma act as a new indicator of renal failure [2].
|
-
- HY-W011849
-
|
|
NF-κB
COX
|
Cancer
|
|
Phenyl β-D-glucopyranoside has anti-cancer and anti-inflammatory activities. Phenyl β-D-glucopyranoside inhibits nitric oxide (NO) production, and the expression of iNOS and COX-2. Phenyl β-D-glucopyranoside also inhibits the nuclear translocation of NF-κB .
|
-
- HY-P10039
-
|
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (1-16) rat is a β-amyloid peptide (Abeta), a metal-binding domain fragment of amyloid. Three amino acid substitutions in β-Amyloid (1-16) rat that differ from humans render rats and mice less susceptible to AD-like neurodegeneration .
|
-
- HY-W015084S
-
|
|
Isotope-Labeled Compounds
Apoptosis
|
Cancer
|
|
β-Ionone- 13C3 is the 13C-labeled β-Ionone. β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. Anti-cancer activity[1].
|
-
- HY-P3515
-
-
- HY-P1854
-
|
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (1-9), an N-terminal fragment of beta amyloid, consists of amino acid residues 1 to 9. β-Amyloid (1-9) contains a B cell epitope, but it does not include T cell epitopes. Omission of residues 1 to 9 from the full-length Alzheimer'sβ-Amyloid peptide 1 to 40 does not prevent the peptide from forming amyloid fibrils or eliminate fibril polymorphism [2].
|
-
- HY-161094
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
Metallo-β-lactamase-IN-12 is a dual inhibitor of metal β-lactamases (MβLs (NDM-1, IMP-1)) and serine β-lactamases (SβLs (OXA-48, KPC-2)), with IC50 values of 0.64 μM, 1.32 μM, 1.01 μM, and 0.57 μM, respectively. Metallo-β-lactamase-IN-12 has antibacterial activity .
|
-
- HY-126039
-
|
|
Integrin
|
Cardiovascular Disease
|
|
L-739758 is an antagonist for αIIbβ3 integrin (platelet glycoprotein IIb/IIIa). L-739758 acts as a peptidomimetic, binds to αIIbβ3 integrin by mimicking the interaction of the RGD (arginine-glycine-aspartic acid) motif, and is involved in the blood coagulation process. L-739758 inhibits platelet aggregation, and is used for thrombosis research .
|
-
- HY-W795507
-
|
|
Adrenergic Receptor
5-HT Receptor
|
Neurological Disease
|
|
Cyanopindolol is an β3-adrenoceptor antagonist. Cyanopindolol is a potent and selective antagonist at the presynaptic serotonin autoreceptor in the rat brain cortex. Cyanopindolol has binding affinity for 5-HT1A and 5-HT1B receptor (Ki: 2.1 and 3 nM respectively) [2] [3].
|
-
- HY-29268
-
|
|
Bacterial
Indoleamine 2,3-Dioxygenase (IDO)
NF-κB
Phosphodiesterase (PDE)
|
Infection
Inflammation/Immunology
Cancer
|
|
β-Carboline 1-carboxylic acid is a β-carboline alkaloid with anti-inflammatory, antifibrotic, antitumor and antibacterial activities. β-Carboline 1-carboxylic acid is the cAMP phosphodiesterase (IC50: 96 µM) and indoleamine 2, 3-dioxygenase (IDO) inhibitor. β-Carboline 1-carboxylic acid is cytotoxic to tumor cells. β-Carboline 1-carboxylic acid inhibits inflammation through the NF-κb/p65 pathway and can reverse epithelial-mesenchymal transition (EMT). In addition, β-Carboline 1-carboxylic acid has strong inhibitory activity against S. aureus (IC50: 47.70 μg/mL) and E. coli (IC50: 19.17 μg/mL) [2] [3] .
|
-
- HY-W104635
-
|
6-Bromo-2-naphthyl-beta-D-galactopyranoside
|
Biochemical Assay Reagents
|
Others
|
|
6-Bromo-2-naphthyl-β-D-galactopyranoside is a chromogenic substrate commonly used to measure β-galactosidase enzyme activity in food, enzyme substrates, and culture media. Upon hydrolysis by β-galactosidase, it generates a yellow precipitate indicating the enzyme's presence.
|
-
- HY-137198
-
-
- HY-133707S
-
-
- HY-133707S1
-
-
- HY-100924
-
|
|
GABA Receptor
|
Neurological Disease
|
|
β-CCB is a ligand for benzodiazepine receptor, which inhibits the binding of [ 3H]flunitrazepam and ethyl (3-[ 3H]carboline-3-carboxylate to benzodiazepine receptors, with Ki of 3-4 nM. β-CCB exhibits proconvulsant and anxiogenic effects .
|
-
- HY-160053
-
|
|
PDGFR
|
Cancer
|
|
Gint4.T aptamer sodium is a nuclease-resistant RNA aptamer-based antagonist targeting platelet-derived growth factor receptor beta (PDGFRβ) (Kd: 9.6 nM). Gint4.T aptamer sodium inhibits PDGFRβ heterodimerization and EGFR transactivation. It can significantly inhibit cell migration and proliferation, induce differentiation and prevent tumor growth in vivo. Gint4.T aptamer sodium specifically inhibits PDGFRβ-mediated tropism of mesenchymal stem cells (MSCs) toward the tumor microenvironment .
|
-
- HY-153702
-
|
|
JAK
|
Cancer
|
|
JAK-IN-27 (compound 1) is an orally active and potent JAKS family kinase inhibitor with IC50s of 3.0 nM (TYK2), 7.7 nM (JAK1), 629.6 nM (JAK3), respectively. JAK-IN-27 inhibits IFN-α2B-induced phosphorylation of STAT3 in Jurkat cells (IC50=23.7 nM) .
|
-
- HY-157035
-
|
|
Proteasome
|
Others
|
|
Proteasome β2c/i-IN-1 (compound 37) is a subunit-selective human proteasome β2c and β2i inhibitor
.
|
-
- HY-P3726
-
|
|
Integrin
|
Inflammation/Immunology
Cancer
|
|
Lys-Gln-Ala-Gly-Asp-Val (KQAGDV) is the six most carboxyl-terminal amino acids in the fibrinogen γ-chain sequence. Lys-Gln-Ala-Gly-Asp-Val is a cell adhesion peptide which is mediated through the α2bβ3 integrin. Lys-Gln-Ala-Gly-Asp-Val is a potent adhesion ligand for smooth muscle cells (SMCs) [2].
|
-
- HY-P3517
-
|
β-EP (6-31), human
|
Opioid Receptor
|
Neurological Disease
Endocrinology
|
|
β-Endorphin, an endogenous opioid neuropeptide, is an opioid receptor agonist. β-Endorphin binds preferentially to μ-opioid receptors and is produced in certain neurons of the central and peripheral nervous system and is one of three endorphins produced in humans. β-Endorphin can be used to reduce stress and maintain homeostasis in the body and is involved in neurological pain perception regulation .
|
-
- HY-W129359
-
|
|
11β-HSD
|
Neurological Disease
Metabolic Disease
|
|
11β-HSD1-IN-8 (compound c6a) is a 11β‑HSD1 inhibitor with an IC50 value of 2.3 μM for human 11β‑HSD1. 11β-HSD1-IN-8 can be used for the research of diabetes and cognitive decline .
|
-
- HY-W106057
-
|
|
11β-HSD
|
Neurological Disease
Metabolic Disease
|
|
11β-HSD1-IN-7 (compound c10a) is a 11β‑HSD1 inhibitor with an IC50 value of 1.9 μM for human 11β‑HSD1. 11β-HSD1-IN-7 can be used for the research of diabetes and cognitive decline .
|
-
- HY-N1940
-
|
Cycloicaritin
|
Interleukin Related
TNF Receptor
MMP
|
Inflammation/Immunology
Cancer
|
|
β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties . β-Anhydroicaritin ameliorates the degradation of periodontal tissue and inhibits the synthesis and secretion of TNF-α and MMP-3 in diabetic rats [2]. β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca 2+, and markedly decreases iNOS protein expression [3].
|
-
- HY-N2056R
-
|
|
Lipoxygenase
Leukotriene Receptor
NF-κB
|
Metabolic Disease
Cancer
|
|
11-Keto-beta-boswellic acid (Standard) is the analytical standard of 11-?Keto-?beta-?boswellic acid. This product is intended for research and analytical applications. 11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production .
|
-
- HY-E70054
-
|
CgtB
|
Others
|
Others
|
|
beta-1,3-Galactosyltransferase (WbgO) (CgtB) acts on N-glycan substrates. beta-1,3-Galactosyltransferase (WbgO) catalyzes the formation of type 1 chains on oligosaccharide, glycopeptide, and glycoprotein substrates, including itself .
|
-
- HY-P99705
-
|
RG-7599; DNIB-0600A; NaPi2b-ADC
|
Antibody-Drug Conjugates (ADCs)
|
Cancer
|
|
Lifastuzumab vedotin (RG-7599; DNIB0600A) is an antibody-drug conjugate (ADC) that comprises a humanized IgG1 anti-NaPi2b monoclonal antibody (MNIB2126A) and a potent antimitotic agent, monomethyl auristatin E (MMAE), which inhibits cell division by blocking the polymerization of tubulin. Lifastuzumab vedotin has the potential for non-small cell lung cancer (NSCLC) and platinum-resistant ovarian cancer (PROC) research .
|
-
- HY-N2188
-
-
- HY-124670
-
-
- HY-148055
-
|
|
β-catenin
|
Cardiovascular Disease
|
|
Wnt/β-catenin agonist 3 (compound 98) is a Wnt/β-catenin signalling pathway agonist. Wnt/β-catenin agonist 3 can be used for the research of osteoporosis .
|
-
- HY-148055A
-
|
|
β-catenin
|
Others
|
|
Wnt/β-catenin agonist 3 hydrochloride is a Wnt/β-catenin signalling pathway agonist. Wnt/β-catenin agonist 3 (compound 98) can be used for the research of osteoporosis .
|
-
- HY-N1238
-
|
Δ4-Sitosterol-3-one; β-Rosasterol oxide
|
Tyrosinase
Endogenous Metabolite
|
Cancer
|
|
β-Sitostenone is a sterols that can be isolated from Cochlospermum vitifolium.β-Sitostenone inhibits tyrosinase activity, and has anti-melanogenic and anti-tumor activities [2] [3].
|
-
- HY-N5137
-
|
OJV-II
|
Others
|
Others
|
|
L-Borneol 7-O-[β-D-apiofuranosyl-(1→6)]-β-D-glucopyranoside is one of the components of the Shengmai injection .
|
-
![L-Borneol 7-O-[β-D-apiofuranosyl-(1→6)]-β-D-glucopyranoside](//file.medchemexpress.com/product_pic/hy-n5137.gif)
- HY-W743741
-
-
- HY-W009841
-
-
- HY-W007578
-
-
- HY-W007942
-
-
- HY-W011089
-
-
- HY-N3870
-
|
|
Others
|
Others
|
|
Ethyl β-fructofuranoside is a natural product .
|
-
- HY-W015231
-
-
- HY-W013185
-
-
- HY-W012379
-
-
- HY-W012451
-
-
- HY-145969
-
|
|
DNA/RNA Synthesis
|
Others
|
|
β-S-ARCA is a mRNA 7-methylguanosine (m 7G) cap analog carrying a phosphorothioate (PS) moiety. mRNAs incorporating β-S-ARCA have elongated cellular half-lives and showed augmented protein expression. β-S-ARCA D1 has been applied in researching experimental mRNA-based anticancer vaccines .
|
-
- HY-N0180S
-
|
|
Endogenous Metabolite
|
Inflammation/Immunology
Cancer
|
|
18β-Glycyrrhetinic acid-d3 is deuterium labeled 18β-Glycyrrhetinic acid. 18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhizae Radix and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.
|
-
- HY-N9187
-
|
|
Others
|
Others
|
|
1α,4β,10β-Trihydroxyguaia-2,11(13)-dien-12,6α-olide is a Sesquiterpenoids product that can be isolated from the rhizomes of Alisma orientale .
|
-
- HY-N7489
-
|
|
Parasite
|
Infection
Inflammation/Immunology
|
|
β-Hederin, a saponin isolated from Hedera helix L.(Araliaceae), possesses antileishmanial activity. β-Hederin exhibits IC50 values of 1.5 μM, 68 nM and 4.57 μM in L. Mexicana promastigotes, L. mexicana amastigotes and THP1 cells, respectively [2].
|
-
- HY-E70044
-
|
|
Glycosyltransferase
|
Metabolic Disease
|
|
beta-1, 3-N-Acetylhexaminyltransferase (LgtA) is a glycosyltransferase, is often used in biochemical studies. beta-1, 3-N-Acetylhexaminyltransferase (LgtA) catalyzes the transfer of N-acetylglucosamine from UDP-GlcNAc to N-acetyllactosamine and lactose .
|
-
- HY-P2294
-
|
|
TGF-β Receptor
|
Inflammation/Immunology
|
|
pm26TGF-β1 peptide is a peptide that mimics a portion of the human TGF-β1 molecule. pm26TGF-β1 peptide shows high affinity for the TGF-β1 receptor. pm26TGF-β1 peptide displays potent anti-inflammatory properties and does not exhibit neutrophils’ chemoattraction [2].
|
-
- HY-148013
-
|
|
Beta-secretase
NF-κB
|
Neurological Disease
|
|
K284-6111 is an orally active inhibitor for protein chitinase 3-like 1 (CHI3L1). K284-6111 reduces the expression of inflammatory proteins such as iNOS, COX-2, GFAP, and Iba-1, inhibits β-secretase and NF-κB, and suppresses Aβ production. K284-6111 ameliorates the Aβ1–42-induced mice memory impairment, and can be used in research about Alzheimer’s Diseases .
|
-
- HY-101895
-
|
FDG
|
Fluorescent Dye
|
Others
|
|
Fluorescein di(β-D-galactopyranoside) is a fluorogenic substrate for β-galactosidase (λex=485 nm, λem=535 nm).
|
-
- HY-141907S
-
-
- HY-144100
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
β-Lactamase-IN-7 (compound 14) is a potent VIM-Type metallo-β-lactamase inhibitor, with Kis of 1.26 μM and 0.54 μM for VIM-1 and VIM-4, respectively. β-Lactamase-IN-7 can effectively inhibit Klebsiella pneumoniae .
|
-
- HY-156180
-
|
|
Drug Metabolite
|
Neurological Disease
|
|
DDC 3′-O-β-D glucuronide (compound 5) is a drug metabolite that can prevent the fibrillization and oligomerization of Aβ42. DDC 3′-O-β-D glucuronide has potential for the research of Alzheimer's disease .
|
-
- HY-129433
-
|
|
17β-HSD
|
Endocrinology
|
|
17β-HSD1-IN-2 (PBRM) is a non-estrogenic and steroidal covalent irreversible inhibitor of 17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) (Ki=368 nM). 17β-HSD1-IN-2 can be used for the research of estrogen-dependent disorders .
|
-
- HY-E70068
-
|
|
Others
|
Others
|
|
Endo-β-N-acetylglucosaminidase (Endo S) is a family 18 glycosyl hydrolase secreted by Streptococcus pyogenes. Endo-β-N-acetylglucosaminidase (Endo S) exclusively hydrolyzes the β-1,4-di-N-acetylchitobiose core of the asparagine-linked complex-type glycan on Asn-297 of the γ-chains of IgG antibody .
|
-
- HY-W145656
-
|
alpha,beta-Trehalose
|
Biochemical Assay Reagents
|
Others
|
|
α,β-Trehalose is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-107373
-
|
L-β-Chloroalanine
|
Bacterial
|
Infection
|
|
β-Chloro-L-alanine is a bacteriostatic amino acid analog which inhibits a number of enzymes, including threonine deaminase and alanine racemase.
|
-
- HY-W145637
-
|
Gb3-beta-MP
|
Biochemical Assay Reagents
|
Others
|
|
Gb -β-MP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W145648
-
|
Methyl-beta-D-thiogalactoside
|
Biochemical Assay Reagents
|
Others
|
|
Methyl-β-D-thiogalactoside is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-P99222
-
|
MGA-031; PRV-031
|
CD3
|
Metabolic Disease
|
|
Teplizumab (MGA-031) is a Fc receptor non-binding anti-human CD3 monoclonal antibody. Teplizumab reduces the loss of beta-cell function. Teplizumab can be used in the research of type 1 diabetes [2].
|
-
- HY-160489
-
|
|
β-catenin
|
Cancer
|
|
PTK7/β-catenin-IN-2 (compound 04967) is an inhibitor of PTK7/β-catenin. It inhibits the binding of PTK7 to β-catenin (IC50: 5.6 μM), thereby inhibiting the signaling of the Wnt/β-catenin pathway. PTK7/β-catenin-IN-2 targets cell growth dependent on the Wnt signaling pathway and has anticancer properties. PTK7/β-catenin-IN-2 also showed inhibitory potency against p53 and MDM2 binding with an IC50 of 157.1 μM .
|
-
- HY-F0004S
-
|
β-NM-d4; NMN-d4
|
Endogenous Metabolite
|
Neurological Disease
Cancer
|
|
β-Nicotinamide mononucleotide-d4 is the deuterium labeled β-Nicotinamide mononucleotide. β-nicotinamide mononucleotide (β-NM) is a product of the nicotinamide phosphoribosyltransferase (NAMPT) reaction and a key NAD+ intermediate. The pharmacological activities of β-nicotinamide mononucleotide include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity[1].
|
-
- HY-151643
-
|
|
ADC Linker
|
Others
|
|
beta-Glc-TEG-Alkyne is a click chemistry reagent containing an alkynes group. beta-Glc-TEG-Alkyne can be used for the research of various biochemical .
|
-
- HY-P3275
-
|
Aβ(17-40)
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (17-40) (Aβ(17-40)) is a fragment of Amyloid-β peptide that has shown neurotoxic activities in SH-SY5Y and IMR-32 cells. β-Amyloid (17-40) can be used for the research of neurological disease .
|
-
- HY-P3845
-
|
|
Amyloid-β
|
Neurological Disease
|
|
(Gly22)-Amyloid β-Protein (1-42) is a peptide fragment of amyloid β-protein (Aβ). Amyloid β-protein is the primary component of both vascular and parenchymal amyloid deposits in Alzheimer's disease. Mutation of Glu22 to Gly22 in Aβ can increase aggregation [2].
|
-
- HY-W197533
-
|
|
Others
|
Neurological Disease
|
|
3-Hydroxymethyl-β-carboline antagonizes the anxiolytic and anticonvulsant actions of Diazepam and reverses the sedative action of Flurazepam. 3-Hydroxymethyl-β-carboline also antagonizes the cerebrovascular and cerebral metabolic depression produced by Flurazepam [2].
|
-
- HY-W049881
-
|
|
Dopamine Receptor
|
Neurological Disease
Inflammation/Immunology
|
|
9-Methyl-β-carboline is a cognitive enhancer with neuroprotective, neurorestorative and anti-inflammatory properties. The behavioral effects of 9-Methyl-β-carboline may be related to the stimulation of hippocampal dopamine levels and dendritic and synaptic proliferation .
|
-
- HY-141379
-
|
|
PROTAC Linkers
ADC Linker
|
Cancer
|
|
N-Bromoacetyl-β-alanine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . N-Bromoacetyl-β-alanine is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [2].
|
-
- HY-E70393I
-
|
|
Others
|
Others
|
|
Bovine Factor IXa Beta is an inactive and highly specific enzyme, with a minimal extended substrate recognition site and a preference for particular amino acid residues at specific subsites. Bovine Factor IXa Beta plays a role in the blood coagulation cascade .
|
-
- HY-N10983
-
|
|
Others
|
Others
|
|
13β-Hydroxylupanine is a natural product that can be found in Caulophyllum robustum Maxim .
|
-
- HY-148378
-
|
|
Drug Intermediate
|
Others
|
|
5β-Dihydrocortisone acetate can be used for the synthesis of tetrahydrocortisone 3-glucuronide .
|
-
- HY-N6824
-
|
|
Others
|
Others
|
|
Hydroxy-β-sanshool is an alkylamide exists in Zanthoxylum bungeanum oil and Zanthoxylum schinifolium oil .
|
-
- HY-N9277
-
|
|
Others
|
Others
|
|
β-Furoyleupatolide (Compound 2) is a compound that can be isolated from Helogyne apaloidea .
|
-
- HY-N11026
-
|
|
Others
|
Others
|
|
22-Beta-Acetoxyglycyrrhizin is a triterpene glucuronide that can be isolated from the roots of Glycyrrhiza .
|
-
- HY-N2930
-
|
|
Others
|
Others
|
|
β-Peltoboykinolic acid is a Triterpenoids product that can be isolated from the rhizomes of Astilbe koreana. .
|
-
- HY-N12342
-
|
|
Others
|
Others
|
|
17β-Tanghinigenin is a kind of glucos-3-ulosyl-thevetoside .
|
-
- HY-N2928
-
|
|
Others
|
Others
|
|
β-Dihydroplumericinic acid is a Iridoids product that can be isolated from the herbs of Plumeria rubra .
|
-
- HY-P991101
-
|
|
Amyloid-β
|
Neurological Disease
|
|
Anti-Amyloid Beta Antibody (scFv59) is a human antibody expressed in CHO cells, targeting Amyloid-β. Anti-Amyloid Beta Antibody (scFv59) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P9984
-
|
rhuMAb beta7; RG7413; PRO145223
|
Integrin
|
Cancer
|
|
Etrolizumab (rhuMAb Beta7) is a gut-selective, anti-β7 integrin monoclonal antibody. Etrolizumab is specific targeting of the β7 subunit of α4β7 and αEβ7 integrins with Ki values of 18 nM and 1800 pM for Human α4β7 and Human αEβ7-293, respectively. Etrolizumab can be used in research of inflammatory bowel disease (IBD) [2].
|
-
- HY-139924S
-
-
- HY-N1590
-
|
|
Others
|
Others
|
|
8β,18-Dihydroxysandaracopimar-15-ene is a compound isolated from Thuja orientalis .
|
-
- HY-170663
-
|
|
Glycosyltransferase
|
Infection
|
|
β-1,4-GALT1-IN-1 (Compound 6) is a β-1,4-GALT1 inhibitor, with an IC50 value of 6.2 μM. β-1,4-GALT1-IN-1 can be used in many pathology investigations such as cancer, autoimmune diseases and viral infections .
|
-
- HY-103524
-
|
(-)-Valerenic Acid
|
GABA Receptor
5-HT Receptor
|
Neurological Disease
|
|
Valerenic acid ((-)-Valerenic Acid), a sesquiterpenoid, is an orally active positive allosteric modulator of GABAA receptors. Valerenic acid is also a partial agonist of the 5-HT5a receptor. Valerenic acid mediates anxiolytic activity via GABAA receptors containing the β3 subunit. Valerenic acid also exhibits potent antioxidant properties [2] [3].
|
-
- HY-N9830
-
|
|
Others
|
Others
|
|
7β-Hydroxycucurbitacin B is a natural product .
|
-
- HY-167570
-
-
- HY-N1633
-
|
|
Others
|
Others
|
|
1-Methoxycarbonyl-β-carboline is a natural alkaloid .
|
-
- HY-W415981
-
-
- HY-105670
-
|
|
nAChR
|
Neurological Disease
|
|
PHA-543613 is a potent, orally active, brain-penetrant and selective α7 nAChR agonist with a Ki of 8.8 nM. PHA-543613 displays selectivity for α7-nAChR over α3β4, α1β1γδ, α4β2 and 5-HT3 receptors . PHA-543613 can be used for the cognitive deficits of Alzheimer's disease and schizophrenia research [2].
|
-
- HY-105670B
-
|
|
nAChR
|
Neurological Disease
|
|
PHA-543613 dihydrochloride is a potent, orally active, brain-penetrant and selective α7 nAChR agonist with a Ki value of 8.8 nM. PHA-543613 dihydrochloride displays selectivity for α7-nAChR over α3β4, α1β1γδ, α4β2 and 5-HT3 receptors . PHA-543613 dihydrochloride can be used for the cognitive deficits of Alzheimer's disease and schizophrenia research [2] [3].
|
-
- HY-E70070
-
|
|
Bacterial
|
Others
|
|
Endo-β-N-acetylglucosaminidase (Endo A) is an Endo-β-N-acetylglucosaminidases (ENGases) from Arthrobacter protophormiae. Endo-β-N-acetylglucosaminidase (Endo A) can transfer a high-mannose type oligosaccharide to monosaccharides such as N-acetylglucosamine (GlcNAc) and glucose to form a new oligosaccharide. Endo-β-N-acetylglucosaminidase (Endo A) catalyzes glycopeptide synthesis by using Man3GlcNAc-oxazoline .
|
-
- HY-N9310
-
|
|
Others
|
Others
|
|
6-Deoxy-3-O-methyl-beta-allopyranosyl(1-4)-beta-cymaronic acid delta-lactone is a natural product .
|
-
- HY-152982
-
-
- HY-135103S
-
|
|
FXR
|
Cancer
|
|
Tauro-β-muricholic acid-d4 (sodium) is the deuterium labeled Tauro-β-muricholic acid sodium. Tauro-β-muricholic Acid sodium (T-βMCA sodium), a endogenous metabolite, is a competitive and reversible farnesoid X receptor (FXR) antagonist, with an IC50 of 40 μM[1][2][3].
|
-
- HY-155535
-
|
|
Endogenous Metabolite
|
Neurological Disease
|
|
17β-HSD10-IN-2 (compound 11) is a benzothiazolylurea-based inhibitor，targeting to 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10)，a multifunctional mitochondrial enzyme. 17β-HSD10-IN-2 don't lead to mitochondrial off-targets and cytotoxic or neurotoxic effects. 17β-HSD10 inhibitors can be used for research in Alzheimer's disease (AD) and hormone-dependent cancer .
|
-
- HY-P1387
-
|
|
Amyloid-β
Apoptosis
|
Neurological Disease
|
|
β-Amyloid (1-40) (rat) is a rat form of the amyloid β-peptide, which accumulates as an insoluble extracellular deposit around neurons, giving rise to the senile plaques associated with Alzheimer's disease (AD). β-Amyloid (1-40) (rat) increases 45Ca 2+ influx, induces neurodegeneration in the rat hippocampal neurons of the CA1 subfield. β-Amyloid (1-40) (rat) induces apoptosis. β-Amyloid (1-40) (rat) can be used for the research of Alzheimer's disease [2].
|
-
- HY-155391
-
|
|
Carbonic Anhydrase
P-glycoprotein
Wnt
β-catenin
|
Cancer
|
|
hCA/Wnt/β-catenin-IN-1 (Compd 15) is an inhibitor of hCA (Ki: 33.6, 24.1, 6.8 nM for hCA II, hCA IX, hCA XII). hCA/Wnt/β-catenin-IN-1 reduces P-gp activity. hCA/Wnt/β-catenin-IN-1 also inhibits Wnt/β-catenin signaling pathway. hCA/Wnt/β-catenin-IN-1 inhibits cancer cell viability, including the NCI/ADR-RES DOX-resistant cell line .
|
-
- HY-123633
-
|
|
Glycosidase
|
Others
|
|
4-Methylumbelliferyl β-D-Glucopyranoside, a β-D-glucoside, is a fluorogenic substrate for β-glucosidase, utilizes to assay β-glucosidase activity . 4-Methylumbelliferyl β-D-Glucopyranoside releases the highly fluorescent 4-methylumbelliferyl (4-MU), which has an emission maximum at 445-454 nm. The excitation maximum for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively [2].
|
-
- HY-137396
-
|
|
Endogenous Metabolite
|
Cardiovascular Disease
|
|
6β-Hydroxy Eplerenone is a metabolite of Eplerenone (HY-B0251). 6β-Hydroxy Eplerenone plays an important role in the research of hypertension, atherosclerosis, chronic systolic heart failure (HF) and cardiovascular (CV) .
|
-
- HY-W588194S
-
-
- HY-W130965
-
|
|
Influenza Virus
Akt
|
Infection
|
|
1-Formyl-beta-carboline is an alkaloid with inhibitory activity against Newcastle disease virus (NDV). 1-Formyl-beta-carboline can effectively inhibit different genotypes of NDV with IC50 values within 10 μM, and its inhibition rate is more than 90% at a concentration of 20 μM. 1-Formyl-beta-carboline mainly exerts its effects by inhibiting the adsorption and entry processes in the NDV life cycle. 1-Formyl-beta-carboline has been identified as a novel HN inhibitor that can directly interact with the NDV HN protein and affect the adsorption of NDV. 1-Formyl-beta-carboline also inhibits the entry of NDV by inhibiting the PI3K/Akt signaling pathway rather than the ERK pathway .
|
-
- HY-E70191
-
|
EC:2.4.1.22; B4GALT2
|
Glycosyltransferase
|
Others
|
|
β-1,4-Galactosyltransferase 2 catal exclusive specificity for the donor substrate UDP-galactose and all transfer galactosein a beta1,4 linkage .
|
-
- HY-W288349
-
-
- HY-P1363F1
-
|
Biotin-amyloid β-peptide (1-42) (human) TFA
|
Amyloid-β
|
Neurological Disease
|
|
Biotin-β-Amyloid (1-42), human TFA (Biotin-Amyloid β-Peptide (1-42) (human) TFA) is the botin labeled β-Amyloid (1-42), human TFA (HY-P1363). β-Amyloid (1-42), human TFA is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease .
|
-
- HY-164429
-
|
|
Integrin
Elastase
|
Cancer
|
|
VIP236 is a small-molecule-drug conjugates (SMDCs) consisting of an αvβ3 integrin binder linked to an optimized Camptothecin (HY-16560) topoisomerase I (TOP1) inhibitor payload. VIP236 exerts anticancer activity by targeting αvβ3 integrins, and it can release payload upon cleavage by neutrophil elastase in the tumor microenvironment .
|
-
- HY-N1525
-
|
|
Others
|
Others
|
|
Quinovic acid 3-O-(6-deoxy-β-D-glucopyranoside) 28-O-β-D-glucopyranosyl ester is a Triterpenoids product that can be isolated from the vines of Uncaria tomentosa .
|
-
- HY-22306S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
β-D-Glucose pentaacetate- 13C6 is the 13C labeled β-D-Glucose pentaacetate[1]. β-D-Glucose Pentaacetate (Penta-O-acetyl-β-D-glucopyranose) is used in biochemical reaction.
|
-
- HY-171296
-
|
|
p38 MAPK
JNK
|
Inflammation/Immunology
|
|
p38 Kinase inhibitor 8 (Compound CCLXXVIII) is the orally active inhibitor for p38β and JNK2α2 with IC50 of 6.3 nM and 53.6 nM. p38 Kinase inhibitor 8 exhibits anti-inflammatory effect in rats collagen-induced arthritis models .
|
-
- HY-D0935A
-
|
MUG
|
Fluorescent Dye
|
Others
|
|
4-Methylumbelliferyl-β-D-glucuronide hydrate is a fluorogenic substrat (λex=362 nm, λem=445 nm). 4-Methylumbelliferyl-β-D-glucuronide hydrate has potential applications in detecting the activity of β-glucuronidase and the number of Escherichia coli [2] [3].
|
-
- HY-N0171AR
-
|
|
Apoptosis
Endogenous Metabolite
|
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
|
Beta-Sitosterol (purity>98%) (Standard) is the analytical standard of Beta-Sitosterol (purity>98%). This product is intended for research and analytical applications. Beta-Sitosterol (purity>98%) is a plant sterol. Beta-Sitosterol (purity>98%) interfere with multiple cell signaling pathways, including cell cycle, apoptosis, proliferation, survival, invasion, angiogenesis, metastasis and inflammation .
|
-
- HY-N9268
-
|
|
Others
|
Others
|
|
8β-Tigloyloxyreynosin is a Sesquiterpenoids product that can be isolated from the roots of Dolomiaea souliei .
|
-
- HY-N1017
-
|
|
Others
|
Others
|
|
11β-Hydroxycedrelone is a natural tetranortriterpenoid compound isolated from the bark of Walsura yunnanensis .
|
-
- HY-119866
-
-
- HY-N2744
-
|
|
Others
|
Others
|
|
7beta-Hydroxyrutaecarpine is a Alkaloids product that can be isolated from the fruits of Euodia ruticarpa .
|
-
- HY-N1721
-
|
|
Others
|
Others
|
|
2β-Hydroxykolavelool is a Diterpenoids product that can be isolated from the tubers of Sagittaria trifolia .
|
-
- HY-N1617
-
|
|
Others
|
Others
|
|
1beta-Hydroxytorilin is a Sesquiterpenoids product that can be isolated from the fruits of Torilis japonica. .
|
-
- HY-W011183
-
|
|
Biochemical Assay Reagents
|
Metabolic Disease
|
|
4-Nitrophenyl-N-acetyl-β-D-glucosaminide, an artificial substrate of N-acetyl-beta-D-hexosaminidase (NAGase), can be used in rapid and accurate rate assay for N-acetyl-beta-D-hexosaminidase. 4-Nitrophenyl-N-acetyl-β-D-glucosaminide is highly soluble and stable. 4-Nitrophenyl-N-acetyl-β-D-glucosaminide can be used for the study of renal tubular injury [2] [3].
|
-
- HY-P1502
-
|
|
Opioid Receptor
|
Neurological Disease
|
|
β-Endorphin, human, a prominent endogenous peptide, existing in the hypophysis cerebri and hypothalamus, is an agonist of opioid receptor, with preferred affinity for μ-opioid receptor and δ-opioid receptor; β-Endorphin, human exhibits antinociception activity.
|
-
- HY-12074
-
|
|
GSK-3
|
Metabolic Disease
|
|
Cazpaullone is a glycogen synthase kinase-3 (GSK-3) inhibitor. Cazpaullone can activate pancreatic beta cell protection and replication. Cazpaullone can be used for the research of diabetes .
|
-
- HY-120270
-
|
|
AMPK
|
Metabolic Disease
|
|
PF-06679142 (Compound 10) is a potent, orally active AMPK activator with an EC50 of 22 nM against α1β1γ1-AMPK. PF-06679142 can be used for diabetic nephropathy research .
|
-
- HY-12012
-
-
- HY-136537A
-
-
- HY-W687950
-
-
- HY-W060074
-
-
- HY-163037
-
-
- HY-W033010
-
|
β-Tropine
|
Drug Derivative
|
Others
|
|
Pseudotropine (β-Tropine), a derivative of Tropane, is a plant alkaloid .
|
-
- HY-168734
-
|
|
Cannabinoid Receptor
|
Inflammation/Immunology
|
|
CB2 receptor agonist 9 (Compound 33) is an orally active agonist for cannabinoid receptor 2 (CB2 receptor) with an EC50 of 16.2 nM. CB2 receptor agonist 9 inhibits the expression of TNF-α, IL-1β and IL-6, exhibits anti-inflammatory efficacy in DDS (HY-116282)-induced mouse acute colitis model .
|
-
- HY-P1524
-
-
- HY-137382
-
-
- HY-113019
-
-
- HY-P1363A
-
|
Amyloid β-peptide (1-42) (human)
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (1-42), human (Amyloid β-peptide (1-42), human) is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease [2] [3].
|
-
- HY-W603112
-
|
|
Biochemical Assay Reagents
|
Others
|
|
β-D-Glucopyranosyl 1-thio-β-D-glucopyranoside is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-W416257
-
|
|
Biochemical Assay Reagents
|
|
|
Methyl 3-O-β-D-galactopyranosyl-β-D-galactopyranoside is a class of biochemical reagent used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It deals with carbohydrate chemistry, glycan formation and degradation enzymology, protein-glycan recognition, and the role of glycans in biological systems. The field is closely related to basic research, biomedicine and biotechnology .
|
-
- HY-144513S
-
-
- HY-N5111
-
|
Aloe-emodin 3-O-β-D-glucoside
|
Others
|
Others
|
|
Aloe-emodin-3-(hydroxymethyl)-O-β-D-glucopyranoside (Aloe-emodin 3-O-β-D-glucoside) is a natural antraquinone .
|
-
- HY-P5811
-
|
CcoTx1; β-TRTX-cm1a
|
Sodium Channel
|
Neurological Disease
|
|
Ceratotoxin-1 (CcoTx1), a peptide toxin, is an voltage-gated sodium channel subtypes inhibitor. Ceratotoxin-1 inhibits Nav1.1/β1, Nav1.2/β1, Nav1.4/β1, and Nav1.5/β1 with IC50 of 523 nM, 3 nM, 888 nM, and 323 nM, respectively. Ceratotoxin-1 also inhibits Nav1.8/β1 .
|
-
- HY-N10944
-
|
|
Others
|
Inflammation/Immunology
|
|
Chrysoobtusin 2-β-D-glucoside is an anthraquinone glycoside found in Cassia obtusifolia. Chrysoobtusin 2-β-D-glucoside may have potential anti-inflammatory and antioxidant activities .
|
-
- HY-161449
-
|
|
11β-HSD
|
Metabolic Disease
|
|
JTT-654 is an orally active, potent and selective11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor. The IC50 of JTT-654 for 11β-HSD1 is 4.65, 0.97, and 0.74 nM in human, rat, and mouse recombinant enzymes, respectively. JTT-654 showed competitive inhibition against human recombinant enzyme. The IC50 value for human 11β-HSD2 is > 30 μM (human 11β-HSD2 is responsible for the reverse reaction against human 11β-HSD1). JTT-654 ameliorates insulin resistance and non-obese type 2 diabetes by inhibiting adipose tissue and liver 11β-HSD1 [2].
|
-
- HY-160488
-
|
|
β-catenin
|
Cancer
|
|
PTK7/β-catenin-IN-1 (compound 01065) is a potent PTK7/β-catenin inhibitor with an IC50 of 8.9 μM and 56.5 μM for PTK7/β-catenin and p53/MDM2, respectively. PTK7/β-catenin-IN-1 has the potential for cancer research .
|
-
- HY-150511
-
|
|
Microtubule/Tubulin
Apoptosis
|
Cancer
|
|
3-(3-Phenoxybenzyl)amino-β-carboline is a potent tubulin inhibitor. 3-(3-Phenoxybenzyl)amino-β-carboline promotes selective degradation of αβ-tubulin heterodimers. 3-(3-Phenoxybenzyl)amino-β-carboline induces G2/M phase cell cycle arrest and apoptosis. 3-(3-Phenoxybenzyl)amino-β-carboline exhibits anticancer activity .
|
-
- HY-N0406R
-
|
|
Others
|
Inflammation/Immunology
|
|
2"-O-beta-L-galactopyranosylorientin (Standard) is the analytical standard of 2"-O-beta-L-galactopyranosylorientin. This product is intended for research and analytical applications. 2"-O-beta-L-galactopyranosylorientin is extracted from the flowers of Trollius ledebouri. 2"-O-beta-L-galactopyranosylorientin involves transporter mediated efflux in addition to passive diffusion and is the substrate of multidrug resistance protein 2 (MRP2). Anti-inflammatory effect [2] [3].
|
-
- HY-P3846
-
|
|
Amyloid-β
|
Neurological Disease
|
|
(Glu20)-Amyloid β-Protein (1-42) is a slower fibrillizing variant of amyloid β-protein (Aβ). The Glu20 mutation reduces the aggregation propensity of Aβ42 and prevents accumulation of the slowly fibrillizing peptide. Amyloid β-protein is the primary component of both vascular and parenchymal amyloid deposits in Alzheimer's disease [2].
|
-
- HY-116284
-
|
Methyl β-D-glucoside
|
Drug Intermediate
|
Others
|
|
Methyl β-D-glucopyranoside is used to synthesize natural glycophenolics via enzymatic caffeoylation .
|
-
- HY-18593
-
|
6-O-alpha-D-Maltosyl-beta-cyclodextrin
|
Biochemical Assay Reagents
|
Others
|
|
Mal-β-CD is a cellular cholesterol modifier which can form soluble inclusion complex with cholesterol.
|
-
- HY-N3554
-
|
(+)-Catechol 7-β-D-xylopyranoside
|
Others
|
Others
|
|
Catechin-7-O-β-D-xylopyranoside is an antioxidant compound with strong DPPH free radical scavenging ability. Catechin-7-O-β-D-xylopyranoside can be extracted from birch inner bark and nepeta stem bark [2].
|
-
- HY-160959
-
|
|
nAChR
|
Neurological Disease
|
|
AN317 is a selective agonist for α6β2-containing nicotinic acetylcholine receptor (nAChR) with Ki of 6.2 nM and 4.1 nM, for α6/α3β2β3 receptor and α4β2 receptor, respectively. AN317 induces dopamine release in the synaptosomes of the rat striatum, enhances dopaminergic neuronal activity in substantia nigra, and exhibits protective efficacy to rat neurons against dopamine neurotoxin MPP +. AN317 exhibits good pharmacokinetic characteristics in rats. AN317 penetrates the blood-brain barrier (BB) .
|
-
- HY-18688
-
|
|
Herbicide
|
Others
|
|
5,6-Bis(4-methoxyphenyl)-2,3-diphenylthieno[3,2-b]furan is a herbicide .
|
-
![5,6-Bis(4-methoxyphenyl)-2,3-diphenylthieno[3,2-b]furan](//file.medchemexpress.com/product_pic/hy-18688.gif)
- HY-118774R
-
|
|
Endogenous Metabolite
|
Inflammation/Immunology
|
|
Propofol β-D-glucuronide (Standard) is the analytical standard of Propofol β-D-glucuronide. This product is intended for research and analytical applications. Propofol β-D-glucuronide is a metabolite of Propofol sulfate and can be used for diagnosis to distinguish colorectal cancer from healthy individuals .
|
-
- HY-135577
-
|
|
Drug Metabolite
|
Infection
|
|
β-Apooxytetracycline is a degradation product of Oxytetracycline (HY-B0275). Oxytetracycline is a widespread antibiotic .
|
-
- HY-N2667
-
|
|
Others
|
Others
|
|
5β-Hydroxycostic acid is a Sesquiterpenoids product that can be isolated from the roots of Aucklandia lappa Decne .
|
-
- HY-N9081
-
|
|
Others
|
Others
|
|
6β-Hydroxyhispanone is a Diterpenoids product that can be isolated from the aerial parts of Leonurus japonicus .
|
-
- HY-W039920
-
|
β-D-Galactosylamine, 98%
|
Biochemical Assay Reagents
|
Others
|
|
1-Amino-1-deoxy-β-D-galactose, 98% is a galactose analog used as a competitive inhibitor to aid in the separation, purification, identification, differentiation, and characterization of β-D-galactosidase and galactose oxidase.
|
-
- HY-W145622
-
|
Gal beta(1-3)[Neu5Ac alpha(2-6)]GlcNAc-beta-pNP
|
Biochemical Assay Reagents
|
Others
|
|
Galβ(1-3)[Neu5Acα(2-6)]GlcNAc-β-pNP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
![Galβ(1-3)[Neu5Acα(2-6)]GlcNAc-β-pNP](//file.medchemexpress.com/product_pic/hy-w145622.gif)
- HY-W008917S1
-
-
- HY-146760S
-
-
- HY-126304A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Glycerophosphoric acid (disodium salt hydrate) (α and β mixture) is a complex contains α and β Glycerophosphoric acid isomers.
|
-
- HY-134924
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Succinyl-β-cycloaltrin is a modified cyclodextrin with unique chemical properties that make it an effective solubilizer and stabilizer for various compounds, especially in the pharmaceutical industry. Succinyl-β-cycloaltrin has a hydrophobic interior and a hydrophilic exterior, enabling it to form stable clathrates with hydrophobic molecules such as drugs and nutrients. This increases their solubility and bioavailability, making them more effective for recreational or nutritional purposes.
|
-
- HY-N3872
-
|
|
Others
|
Others
|
|
Ethyl β-D-glucopyranoside (compound 10) is a kind of phenolic compound. Ethyl β-D-glucopyranoside can be isolated from ethanolic extract of Scabiosa stellata LS.
|
-
- HY-W040224
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Octyl β-D-thioglucopyranoside is a non-ionic detergent that can be used in the field of membrane biochemistry. Octyl β-D-thioglucopyranoside has the ability to solubilize E. coli membrane proteins .
|
-
- HY-N6616R
-
|
|
Others
|
Others
|
|
Pinocembrin-7-O-β-D-glucopyranoside (Standard) is the analytical standard of Pinocembrin-7-O-β-D-glucopyranoside. This product is intended for research and analytical applications. Pinocembrin-7-O-β-D-glucopyranoside (Pinocembrin 7-O-β-D-Glucoside) is is a flavanone that enhances lipid peroxidation .
|
-
- HY-N0171B
-
|
β-Sitosterol (purity>75%); 22,23-Dihydrostigmasterol (purity>75%)
|
Apoptosis
|
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
|
Beta-Sitosterol (purity>75%) is a phytosterol with oral activity. Beta-Sitosterol (purity>75%) interferes with a variety of cell signaling pathways, including the cell cycle, apoptosis and cell proliferation. Beta-Sitosterol (purity>75%) has anti-inflammatory, antioxidant, and antitumor activities [2] [3].
|
-
- HY-145969A
-
|
|
DNA/RNA Synthesis
|
Cancer
|
|
β-S-ARCA (triammonium) is a mRNA 7-methylguanosine (m 7G) cap analog carrying a phosphorothioate (PS) moiety. mRNA incorporating β-S-ARCA (triammonium) can prolong cellular half-life and increase protein expression. β-S-ARCA (triammonium) can be used in research of mRNA-based anti-cancer vaccines .
|
-
- HY-N2769
-
|
|
Others
|
Others
|
|
9β-Hydroxy-ageraphorone is a natural cadinene sesquiterpene compound .
|
-
- HY-W739772
-
-
- HY-P1286A
-
-
- HY-W587779
-
|
|
Biochemical Assay Reagents
|
|
|
o-Nitrophenyl β-D-galactopyranoside-6-phosphate cyclohexylammonium is a chromogenic substrate with activity for β-galactosidase detection. The use of o-Nitrophenyl β-D-galactopyranoside-6-phosphate cyclohexylammonium can help researchers quickly identify and quantify β-galactosidase activity.
|
-
- HY-164462
-
|
|
PKC
NF-κB
Apoptosis
|
Cancer
|
|
BHA536 is an orally active selective inhibitor for PKCα/β and NF-kB signaling pathway. BHA536 inhibits the proliferation of CD79-mutated ABC DLBCL cell, arrests cell cycle at G1 phase, and induces apoptosis in TMD8 cell. BHA536 exhibits antitumor efficacy in mice .
|
-
- HY-W604882
-
|
Orthonitrophenyl-beta-D-fucopyranoside, 98%
|
Biochemical Assay Reagents
|
Others
|
|
Orthonitrophenyl-β-D-fucopyranoside, 98% is a chromogenic substrate used in various enzyme assays to detect the presence of fucosidase.
|
-
- HY-W007497S
-
-
- HY-N13541
-
|
|
Others
|
Others
|
|
(19S,23R)-5β,19-Epoxy-19,23-dimethoxycucurbita-6,24-dien-3β-ol is a natural product .
|
-
- HY-162026
-
|
|
11β-HSD
|
Metabolic Disease
|
|
11β-HSD1-IN-14 (Compound 17) is a selective inhibitor for 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1), with IC50 of 74 nM for human HSD1, and 603 nM for HSD1 expressed HEK293 cell .
|
-
- HY-106288
-
|
|
PTHR
|
Cancer
|
|
Human PTHrP-(1-36) is a secretory form of PTHrP with anticalciuric effects. Human PTHrP-(1-36) enhances beta cell function and proliferation. Human PTHrP-(1-36) can be used in the research of humoral hypercalcemia of malignancy (HHM) and hyperparathyroidism [3].
|
-
- HY-P2294A
-
|
|
TGF-β Receptor
|
Inflammation/Immunology
|
|
pm26TGF-β1 TFA peptide is a peptide that mimics a portion of the human TGF-β1 molecule. pm26TGF-β1 peptide TFA shows high affinity for the TGF-β1 receptor. pm26TGF-β1 peptide TFA displays potent anti-inflammatory properties and does not exhibit neutrophils’ chemoattraction [2].
|
-
- HY-100207
-
CP21R7
5 Publications Verification
CP21
|
GSK-3
|
Cancer
|
|
CP21R7 is potent GSK-3β inhibitor, with an IC50 of 1.8 nM; CP21R7 also shows inhibitory activitiy against PKCα, with an IC50 of 1900 nM.
|
-
- HY-N3658
-
|
|
Others
|
Others
|
|
Cycloart-25-ene-3β,24-diol is a natural triterpene .
|
-
- HY-W701013
-
-
- HY-151520
-
|
|
Wnt
|
Cancer
|
|
Wnt/β-catenin agonist 4 (Derivative 83) is an agonist of Wnt that activates Wnt/β-catenin signal transmission .
|
-
- HY-W714951S
-
-
- HY-P1567
-
|
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (10-35), amide is composed of 26 aa (10-35 residues of the Aβ peptide) and is the primary component of the amyloid plaques of Alzheimer’s disease.
|
-
- HY-148002
-
|
|
Drug Metabolite
|
Others
|
|
1'-Hydroxy Midazolam-β-D-glucuronide is a β-D-glucuronide that acts as a drug metabolite, human urine metabolite, and human serum metabolite .
|
-
- HY-134425
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
β-Methylcrotonyl coenzyme A lithium is an intermediate in leucine metabolism and can be used as a substrate to study the specificity and kinetics of β-methylcrotonyl coenzyme A carboxylase (MCCase) .
|
-
- HY-124463
-
-
- HY-N1152
-
|
|
Others
|
Inflammation/Immunology
|
|
threo-Guaiacylglycerol beta-coniferyl ether is a lignan that can inhibit NO production. threo-Guaiacylglycerol beta-coniferyl ether exhibits anti-neuroinflammatory activities .
|
-
- HY-N2926
-
|
|
Parasite
|
Infection
|
|
β-Carboline-1-propionic acid is a alkaloid which can be extracted from Ailanthus altissima. β-Carboline-1-propionic acid can be used as an antileishmanial agent [2].
|
-
- HY-W015084
-
|
|
Apoptosis
|
Cancer
|
|
β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. Anti-cancer activity .
|
-
- HY-W145581
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Triacetyl-β-cyclodextrin is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-P2763
-
|
|
Biochemical Assay Reagents
|
Others
|
|
beta-Glucanase is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-N11498
-
|
|
Others
|
Others
|
|
β-Obscurine is a lycopodine-type alkaloid, which can be isolated from the club moss Lycopodium casuarinoides .
|
-
- HY-W203728
-
-
- HY-W585922
-
|
|
Drug Derivative
|
Others
|
|
3β-Cholic acid is a derivative of cholic acid (HY-N0324), and can be found in human feces .
|
-
- HY-W127641
-
|
|
Biochemical Assay Reagents
|
Others
|
|
β-Methylcholine Chloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-N13289
-
|
|
Others
|
Cancer
|
|
12β-Hydroxyresibufogenin is a bufadienolide, which shows significant inhibitory activities against cancer cell lines .
|
-
- HY-P9911A
-
|
|
Integrin
|
Inflammation/Immunology
|
|
Vedolizumab (anti-α4β7-integrin) is a humanized IgG1 monoclonal antibody that targets the α4β7 integrin for the treatment of ulcerative colitis and Crohn's disease [2].
|
-
- HY-P0178
-
|
|
Integrin
|
Inflammation/Immunology
|
|
LXW7, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor. LXW7 has a high binding affinity to αvβ3 integrin with an IC50 of 0.68 μM. LXW7 increases phosphorylation of VEGFR-2 and activation of ERK1/2. Anti-inflammatory effect [2] [3].
|
-
- HY-N4099R
-
|
|
Others
|
Inflammation/Immunology
|
|
Luteolin-3-O-beta-D-glucuronide (Standard) is the analytical standard of Luteolin-3-O-beta-D-glucuronide. This product is intended for research and analytical applications. Luteolin-3-O-beta-D-glucuronide is a luteolin glucosiduronic acid consisting of luteolin having a beta-D-glucosiduronic acid residue attached at the 3'-position.
|
-
- HY-N3814
-
|
|
Others
|
Inflammation/Immunology
|
|
ent-16β,17-Dihydroxykauran-19-oic acid is an anti-inflammatory agent, which can be isolated from Siegesbeckia pubescens herb. ent-16β,17-Dihydroxykauran-19-oic acid inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglia .
|
-
- HY-N12079
-
|
|
Biochemical Assay Reagents
|
Cancer
|
|
(2,4-Dichloro-3,5-dimethoxyphenyl) methyl 6-O-β-D-glucopyranosyl-β-D-glucopyranoside is an anticancer agent that inhibits the proliferation of lung cancer A549 cells (IC50=29 μΜ). (2,4-Dichloro-3,5-dimethoxyphenyl) methyl 6-O-β-D-glucopyranosyl-β-D-glucopyranoside can be obtained from Lilium regale and can be used in cancer research .
|
-
- HY-N0936
-
Coixol
1 Publications Verification
6-Methoxy-2-benzoxazolinone; 6-MBOA
|
Others
|
Inflammation/Immunology
|
|
Coixol (6-Methoxy-2-benzoxazolinone; 6-MBOA) is a potent and orally active anti-inflammatory agent. Coixol decreases the iNOS protein expression. Coixol inhibits the production of TNF-α, IL-6, and IL-1β. Coixol improves glucose tolerance and plasma insulin. Coixol decreases the blood glucose level [2] [3].
|
-
- HY-W145659
-
|
Di-beta-D-Xylopyranosylamine
|
Biochemical Assay Reagents
|
Others
|
|
Di(β-D-xylopyranosyl)amine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-14759
-
|
PAZ-417
|
PAI-1
Amyloid-β
|
Neurological Disease
|
|
Aleplasinin is an orally active, potent, BBB-penetrated and selectiveSERPINE1 (PAI-1, Plasminogen activator inhibitor-1) inhibitor. Aleplasinin increases amyloid-β (Aβ) catabolism and ameliorates amyloid-related pathology. Aleplasinin improves memory deficiency. Aleplasinin can be used for Alzheimer's disease research [2].
|
-
- HY-136542
-
-
- HY-W348476
-
-
- HY-W041992
-
-
- HY-W011445
-
-
- HY-W328332
-
-
- HY-128737
-
-
- HY-130256
-
|
|
PROTACs
Epigenetic Reader Domain
|
Cancer
|
|
β-NF-JQ1 is a PROTAC that recruits Aryl Hydrocarbon Receptor E3 ligase to target proteins. β-NF-JQ1 is directed against bromodomain-containing (BRD) proteins using β-NF as an AhR ligand, induces the interaction of AhR and BRD proteins, and displays effective anticancer activity that correlated with protein knockdown activity .
|
-
- HY-D0886
-
|
|
Phosphatase
Endogenous Metabolite
ERK
|
Metabolic Disease
Cancer
|
|
β-Glycerophosphate disodium salt pentahydrate is a bioactive endogenous metabolite and a phosphatase inhibitor. β-Glycerophosphate disodium salt pentahydrate plays an important role in inducing and maintaining osteoblast differentiation, mineral metabolism and signal transduction, and can be used as a drug carrier to form heat-sensitive hydrogels. β-Glycerophosphate disodium salt hydrate accelerates the calcification of vascular smooth muscle cells [2] [3] .
|
-
- HY-143415
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
Metallo-β-lactamase-IN-7 is a potent VIM-Type metallo-β-lactamase inhibitor with IC50s of 0.019 μM, 13.64 μM, 0.38 μM for VIM-2, VIM-1 and VIM-5. Metallo-β-lactamase-IN-7 potentiate antibacterial activity of Meropenem against the Gram-negative bacterial strains .
|
-
- HY-151627
-
-
- HY-N3825
-
|
|
Apoptosis
|
Cancer
|
|
ent-Kaurane-3α,16β,17-triol (Compound 3) is an anticancer agent. ent-Kaurane-3α,16β,17-triol induces apoptosis in HCT116 cells .
|
-
- HY-N9398
-
|
|
Sirtuin
|
Cancer
|
|
3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol, a SIRT1 activator, exhibits significant stimulation of SIRT1 activity. Anti-tumor activity .
|
-
- HY-P2289
-
|
pBD-1
|
Bacterial
|
Infection
|
|
β-defesin 1 (pig) (pBD-1) is an endogenous and constitutively expressed antimicrobial peptide (AMP) from porcine tissues, particularly expresses in pig mucosal epithelial sites. β-defesin 1 (pig) has antimicrobial activities and contributes to mucosal and systemic host defenses in pigs .
|
-
- HY-N0411S1
-
-
- HY-N13707
-
|
|
Reactive Oxygen Species
|
Others
|
|
3′-Hydroxytectorigenin-7-O-β-D-xylosyl-(1→6)-β-D-glucopyranoside is an antioxidant that can be found in Pueraria montana var. lobata. It exhibits DPPH radical scavenging activity, with an IC50 value of 42 μg/mL .
|
-
- HY-W353102
-
|
|
Endogenous Metabolite
|
Metabolic Disease
Endocrinology
|
|
Estradiol 17-(β-D-Glucuronide), a metabolite of estrogen, is well known to cause intrahepatic cholestasis in humans. Estradiol 17-(β-D-Glucuronide) is a high-affinity substrate for oatp organic anion transporter .
|
-
- HY-134426
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
DL-β-Hydroxybutyryl coenzyme A lithium is an intermediate in the fermentation of butyric acid and the metabolism of lysine and tryptophan, and is produced from β-hydroxybutyric acid by short-chain-CoA synthase [2].
|
-
- HY-N4099
-
|
|
Others
|
Inflammation/Immunology
|
|
Luteolin-3-O-beta-D-glucuronide is a luteolin glucosiduronic acid consisting of luteolin having a beta-D-glucosiduronic acid residue attached at the 3'-position.
|
-
- HY-137236
-
-
- HY-N2760
-
|
|
Others
|
Others
|
|
Sandaracopimaradien-3β-ol is a natural isopimarane-type diterpenoid .
|
-
- HY-118774S
-
-
- HY-142598S
-
-
- HY-142266S
-
-
- HY-N3657
-
|
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Others
|
Others
|
|
Cycloart-23-ene-3β,25-diol is a natural crystalline triterpene .
|
-
- HY-132480S
-
-
- HY-117623
-
|
PF-249
|
AMPK
|
Metabolic Disease
|
|
PF-06685249 (PF-249) is a potent and orally active allosteric AMPK activator with an EC50 of 12 nM for recombinant AMPK α1β1γ1. PF-06685249 can be used for diabetic nephropathy research .
|
-
- HY-B0708
-
-
- HY-W145539
-
|
GlcNAc beta(1-3)[GlcNAc beta(1-6)]GalNAc-alpha-Thr
|
Biochemical Assay Reagents
|
Others
|
|
GlcNAcβ(1-3)[GlcNAcβ(1-6)]GalNAc-α-Thr is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
![GlcNAcβ(1-3)[GlcNAcβ(1-6)]GalNAc-α-Thr](//file.medchemexpress.com/product_pic/hy-w145539.gif)
- HY-P3858
-
|
|
Amyloid-β
|
Neurological Disease
|
|
(D-Asp1)-Amyloid β-Protein (1-42) is a peptide fragment of amyloid β-protein (Aβ). Amyloid β-protein is the primary component of both vascular and parenchymal amyloid deposits in Alzheimer's disease .
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- HY-P1548
-
|
Human β-CGRP; CGRP-II (Human)
|
CGRP Receptor
|
Cardiovascular Disease
Inflammation/Immunology
|
|
β-CGRP, human (Human β-CGRP) is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC50s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells .
|
-
- HY-159106
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-
- HY-N0180
-
-
- HY-141873
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|
|
β-catenin
|
Others
|
|
Wnt/β-catenin agonist 2 is a potent Wnt agonist. Wnt/β-catenin agonist 2 activates Wnt/β-catenin signaling and can be used in the research of diseases related to the signal transduction . (From patent WO2007078113A1, compound 39)
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-
- HY-155010
-
|
|
Steroid Sulfatase
|
Metabolic Disease
|
|
Steroid sulfatase/17β-HSD1-IN-5 is a irreversible inhibitor of steroid sulfatase (STS) .Steroid sulfatase/17β-HSD1-IN-5 is a reversible and selective inhibitor of 7β-hydroxysteroid dehydrogenase type1 (17β-HSD1), with IC50s of 43 nM and 6.2μM for 17β-HSD1 and 17β-HSD2, respectively. Steroid sulfatase/17β-HSD1-IN-5 can be used for metabolic disease (especially for endometriosis) research .
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- HY-N3824
-
|
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Others
|
Others
|
|
ent-Atisane-3β,16α,17-triol is a compound that can be isolated from the acetone extract of roots of Euphorbia sieboldiana. ent-Atisane-3β,16α,17-triol is a natural control product .
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- HY-157796
-
|
|
Adrenergic Receptor
|
Metabolic Disease
|
|
β2AR agonist 4 (compound A19) is a potent and selective β2-Adrenoceptor agonist with an EC50 of 3.7 pM. β2AR agonist 4 suppresses the inflammatory cytokines and leukocytes upregulation and improves lung function in COPD rat model .
|
-
- HY-U00278
-
|
(3β,20β)-3-(3-Carboxy-1-oxopropoxy)olean-9(11)-en-29-oic acid
|
Drug Derivative
|
Inflammation/Immunology
|
|
Deloxolone has the potential for inflammatory, ischemic and proliferative diseases treatment.
|
-
- HY-W155446
-
|
Decyl 4-O-α-D-glucopyranosyl-1-thio-β-D-glucopyranoside
|
Biochemical Assay Reagents
|
Others
|
|
Decyl beta-d-thiomaltopyranoside (Decyl 4-O-α-D-glucopyranosyl-1-thio-β-D-glucopyranoside) is a biochemical assay reagent.
|
-
- HY-101953
-
|
D'Orenone
|
RAR/RXR
|
Others
|
|
β-Apo-13-carotenone (D'Orenone) is a naturally occurring β-apocarotenoid functioned as an antagonist of RXRα.
|
-
- HY-W587959
-
-
- HY-137426
-
-
- HY-W040202
-
-
- HY-W040166
-
-
- HY-W008866
-
-
- HY-W010924
-
-
- HY-W693175
-
-
- HY-N2212
-
-
- HY-W010888
-
-
- HY-W022446
-
-
- HY-137902
-
-
- HY-W338768
-
-
- HY-W013210
-
-
- HY-W142009
-
-
- HY-W561088
-
-
- HY-W040203
-
-
- HY-137116
-
-
- HY-W013048
-
-
- HY-W011216
-
-
- HY-W142120
-
-
- HY-139138
-
-
- HY-134450
-
-
- HY-W142163
-
-
- HY-134935
-
-
- HY-W015457
-
-
- HY-W015993
-
-
- HY-137522A
-
|
3'-Azido-3'-deoxythymidine β-D-glucuronide
|
Drug Metabolite
|
Others
|
|
Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the major metabolite of Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection [2].
|
-
- HY-162722
-
|
|
GSK-3
|
Others
|
|
GSK-3 inhibitor 6 (2) is a CNS penetrated GSK-3 inhibitor, with IC50 values of 29 nM and 24 nM for GSK-3α and GSK-3β, respectively .
|
-
- HY-142128
-
|
Cyclohexyl-hexyl-β-D-maltoside
|
Bacterial
|
Infection
|
|
Cymal-6 (Cyclohexyl-hexyl-β-D-maltoside) is a potent TEM-1 beta-lactamase inhibitor with an Ki value of 40.05 µM. Cymal-6 (Cyclohexyl-hexyl-β-D-maltoside) can be used as glycosidic surfactant [2].
|
-
- HY-148525
-
|
β2AR/M-receptor agonist-2
|
mAChR
Adrenergic Receptor
|
Cardiovascular Disease
Inflammation/Immunology
|
|
β2AR/M-receptor agonist-2 (compound 15) is a muscarinic antagonist and β2 adrenoceptor agonist (MABA). β2AR/M-receptor agonist-2 shows potency to β2 adrenoceptor with an EC50 value of 3.7 nM. β2AR/M-receptor agonist-2 also has potency to human cloned M3 receptor with a Ki value of 0.73 nM. β2AR/M-receptor agonist-2 is a potent bronchodilator, it can be used for the research of chronic obstructive pulmonary disease (COPD) .
|
-
- HY-W671745
-
|
|
Others
|
Others
|
|
Entadamide A 2'-O-(6''-O-β-D-glucopyranosyl)-β-D-glucopyranoside (MFLNH I) (compound 5) can be isolated from the seed kernel of Entada rheedei. Entada rheedei is a medicinal plant from Thailand that is used to suppress stomach pain .
|
-
- HY-143614
-
|
|
Thyroid Hormone Receptor
|
Metabolic Disease
|
|
THR-β agonist 3 is a potent agonist of THR-β. THR-β agonist 3 has the potential for the research of metabolic diseases such as obesity, hyperlipidemia, hypercholesterolemia, diabetes and other conditions such as steatosis and non-alcoholic steatohepatitis (NASH), atherosclerosis and other related conditions and diseases (extracted from patent WO2021129827A1, compound 6) .
|
-
- HY-157935
-
|
|
Endogenous Metabolite
|
Neurological Disease
|
|
17β-HSD10-IN-3 (compound 23) is a 17β-HSD10 inhibitor with the IC50 of 5.59 μM. 17β-HSD10-IN-3 shows no cell cytotoxicity toward the HEK-293 cell line up to 20 μM .
|
-
- HY-143613
-
|
|
Thyroid Hormone Receptor
|
Metabolic Disease
|
|
THR-β agonist 2 is a potent agonist of THR-β. THR-β agonist 2 has the potential for the research of metabolic diseases such as obesity, hyperlipidemia, hypercholesterolemia, diabetes and other conditions such as steatosis and non-alcoholic steatohepatitis (NASH), atherosclerosis and other related conditions and diseases (extracted from patent WO2021121210A1, compound 3) .
|
-
- HY-W324220
-
|
|
11β-HSD
|
Metabolic Disease
|
|
11β-HSD1-IN-10 (compound c3a) is a potent 11β-HSD1 inhibitor (IC50=1.8 µM for human). 11β-HSD1-IN-10 can be used in studies of obesity, hyperglycemia and cognitive impairment .
|
-
- HY-142917
-
|
|
Thyroid Hormone Receptor
|
Metabolic Disease
|
|
THR-β agonist 4 is a potent agonist of THR-β. THR-β agonist 4 has the potential for the research of metabolic diseases such as obesity, hyperlipidemia, hypercholesterolemia, diabetes and other conditions such as steatosis and non-alcoholic steatohepatitis (NASH), atherosclerosis and other related conditions and diseases (extracted from patent WO2021143706A1, compound 72) .
|
-
- HY-112426
-
-
- HY-18668
-
|
|
Integrin
|
Cancer
|
|
Integrin antagonist 27 is a small molecule integrin αvβ3 antagonist with binding affinity of 18 nM, as s novel anticancer agent.
|
-
- HY-W016083
-
|
β-Naphthoxyethanol
|
Others
|
Others
|
|
Anavenol (β-Naphthoxyethanol) is an agent that can suppress or relieve pain, used for horses .
|
-
- HY-N5153
-
|
|
Others
|
Others
|
|
12β-Acetoxyganoderic Acid θ is a triterpenoid that can be isolated from G. lucidum .
|
-
- HY-W016424
-
-
- HY-N3534
-
|
Cannabispirol
|
Others
|
Others
|
|
β-Cannabispiranol (Cannabispirol) is a spiro-compound that can be isoalted from Thailand Cannabis .
|
-
- HY-W290273
-
|
2-Nitrophenyl-beta-D-thiogalactopyranoside
|
Biochemical Assay Reagents
|
Others
|
|
2-Nitrophenyl-β-D-thiogalactopyranoside is a chromogenic substrate used to detect the presence of galactosidase in various biological and biochemical assays.
|
-
- HY-P2999
-
|
ENGase
|
Endogenous Metabolite
|
Others
|
|
Endo-β-N-acetylglucosaminidase (ENGase) is cytosolic deglycosylating enzyme that hydrolyzes the N-linked oligosaccharides. Endo-β-N-acetylglucosaminidase can be used for glycan analysis on glycoproteins and preparation of precursors for glycosylated compounds, is often used in biochemical studies .
|
-
- HY-107271
-
|
|
Others
|
Cancer
|
|
Imperialine 3-β-D-glucoside is the glycoside of Imperialine (HY-N0696). Imperialine 3-β-D-glucoside may exhibit anti-tumor properties against multi-agent resistant tumor cells .
|
-
- HY-N2100
-
|
|
Reactive Oxygen Species
|
Metabolic Disease
|
|
6'-O-beta-D-Glucosylgentiopicroside is a secoiridoid isolated from the roots of G. straminea. 6'-O-beta-D-Glucosylgentiopicroside strongly suppresses N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide generation .
|
-
- HY-148225
-
|
|
Drug Metabolite
|
Cancer
|
|
Fulvestrant 3-β-D-Glucuronide, a metabolite, is glucuronide and sulfate conjugates of Fulvestrant (HY-13636), a pure anti-estrogenic steroid. Fulvestrant 3-β-D-Glucuronide can be used for the research of breast cancer .
|
-
- HY-P1866A
-
|
|
Opioid Receptor
|
Neurological Disease
|
|
β-Endorphin, equine TFA is an endogenous opioid peptide, which binds at high affinity to both μ/δ opioid receptors. β-Endorphin, equine TFA has analgesic properties [2] [3] .
|
-
- HY-P1362F
-
|
Cy5-Amyloid β Peptide (42-1)(human)
|
Amyloid-β
|
Neurological Disease
|
|
Cy5-β-Amyloid (42-1), human is a Cy5 fluorescently-labelled β-Amyloid (42-1, human) peptide (λex= 633 nm and λem= 670 nm) .
|
-
- HY-158210
-
|
|
Wnt
β-catenin
MDM-2/p53
|
Cancer
|
|
Wnt/β-catenin-IN-3 (compound 17) is a Wnt/β-catenin inhibitor with low micromolarGI50s against various cancer cells. Wnt/β-catenin-IN-3triggers G2/M cell cycle arrest though activation of p53-p21 pathway as well as intrinsic and extrinsic apoptotic death of colon cancer cells .
|
-
- HY-146165
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
Metallo-β-lactamase-IN-8 (compound 17) is a potent, reversible and competitive broad-spectrum inhibitor of metallo-β-lactamases (MβLs), with IC50s of 1.3 μM, 5.7 μM, 9.8 μM, and 9.9 μM for L1, ImiS, IMP-1 and VIM-2, respectively. Metallo-β-lactamase-IN-8 exhibits antibacterial activity .
|
-
- HY-P2866
-
|
|
Endogenous Metabolite
|
Others
|
|
β-N-Acetylhexosaminidase (EC 3.2.1.52) is an exoglycosidase that catalyzes the hydrolysis of terminal non-reducing β-N-acetylgalactosamine and glucosamine residues in oligosaccharides for epigenetic applications .
|
-
- HY-124265
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
4β-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation .
|
-
- HY-W701984
-
|
|
Glucocorticoid Receptor
|
Endocrinology
|
|
11β-Hydroxyetiocholanolone is a metabolite of Hydrocortisone (HY-N0583). Hydrocortisone is a steroid hormone or glucocorticoid secreted by the adrenal cortex.
|
-
- HY-N6879R
-
|
|
Others
|
Metabolic Disease
|
|
DiosMetin 7-O-β-D-Glucuronide (Standard) is the analytical standard of DiosMetin 7-O-β-D-Glucuronide. This product is intended for research and analytical applications. DiosMetin 7-O-β-D-Glucuronide is an antioxidant constituent in the fruits of Luffa cylindrical .
|
-
- HY-N4088R
-
|
|
Fungal
|
Infection
Endocrinology
|
|
Pseudolaric acid A-O-β-D-glucopyranoside (Standard) is the analytical standard of Pseudolaric acid A-O-β-D-glucopyranoside. This product is intended for research and analytical applications. Pseudolaric acid A-O-β-D-glucopyranoside, isolated from Cortex Pseudolaricis, demonstrates antifungal and antifertility activities .
|
-
- HY-W416254
-
|
|
Biochemical Assay Reagents
|
Others
|
|
4-Nitrophenyl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-114321
-
|
|
Wnt
|
Cancer
|
|
Wnt/β-catenin agonist 1 (compound 3f) is a Wnt/β-catenin signalling pathway agonist, with an EC50 of 0.27 μM .
|
-
- HY-E70285
-
|
B4GALT1 (Y285L)
|
Endogenous Metabolite
|
Metabolic Disease
|
|
beta-1,4-Galactosyltransferase 1 (Y285L) can enzymatic synthesis of the LacdiNAc motif. beta-1,4-Galactosyltransferase 1 (Y285L) can transfer of GalNAc from UDP-GalNAc .
|
-
- HY-N13510
-
|
|
Others
|
Others
|
|
(19R,23S)-5β,19-Epoxy-19,23-dimethoxycucurbita-6,24-dien-3β-ol is a triterpenoid product that can be isolated from Momordica charantia .
|
-
- HY-N13492
-
|
|
Others
|
Others
|
|
(19R,23E)-5β,19-Epoxy-19-methoxycucurbita-6,23,25-trien-3β-ol is a Triterpene product that can be isolated from Momordica charantia .
|
-
- HY-148526
-
|
|
Adrenergic Receptor
mAChR
|
Metabolic Disease
|
|
β2AR/M3-receptor agonist-1 (example 9) is a potent β2AR and M3 receptor agonist. β2AR/M3-receptor agonist-1 shows M3 receptor affinity with a pIC50 value of 9.3. β2AR/M3-receptor agonist-1 has the potential for the research of respiratory tract disorders .
|
-
- HY-P0178A
-
|
|
Integrin
|
Inflammation/Immunology
|
|
LXW7 TFA, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor. LXW7 has a high binding affinity to αvβ3 integrin with an IC50 of 0.68 μM. LXW7 TFA increases phosphorylation of VEGFR-2 and activation of ERK1/2. Anti-inflammatory effect [2] [3].
|
-
- HY-162659
-
|
|
Adrenergic Receptor
|
Others
|
|
β2AR ligand 1 (Compound 4) is a homobivalent bitopic ligand for β2 adrenergic receptor (β2AR) on the orthosteric binding site (OBS) and the metastable binding sites (MBS) .
|
-
- HY-113949A
-
|
|
Drug Isomer
|
Others
|
|
Methyl 2,3-O-Isopropylidene-β-L-ribofuranoside is an enantiomer of Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside. Methyl 2,3-O-Isopropylidene-β-L-ribofuranoside is a derivative of L-ribose .
|
-
- HY-W039892
-
|
pNPG_1
|
β-glucuronidase
|
Others
|
|
4-Nitrophenyl β-D-glucuronide (pNPG_1) is aderivative of 4-nitrophenol 4-Nitrophenyl β-D-glucuronide is a chromogenic compound and is the chromogenic substrate for β-glucuronidase .
|
-
- HY-P990140
-
|
|
MHC
|
Others
|
|
Anti-Rat β-2-Microglobulin Antibody (4C9) is a mouse-derived IgG1 type antibody inhibitor, targeting to rat β-2-Microglobulin.
|
-
- HY-152105
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
Metallo-β-lactamase-IN-9 (Compound 23) is a pan metallo-beta-lactamase (MBL) inhibitor with IC50s of 35, 269 and 369 nM against NDM-1, VIM-1 and IMP-1, respectively .
|
-
- HY-147342
-
|
|
DNA/RNA Synthesis
|
Others
|
|
β-Benzamide adenine dinucleotide is a bioactive metabolite of benzamide nucleoside and a potent inhibitor of inosine 5 '-monophosphate dehydrogenase (IMPDH). β-Benzamide adenine dinucleotide is a potent, competitive inhibitor of human NAD kinase (Ki = 90 µM) [2].
|
-
- HY-W293502
-
|
2-Chloro-4-nitrophenyl-beta-D-galactopyranoside
|
Biochemical Assay Reagents
|
Others
|
|
2-Chloro-4-nitrophenyl-β-D-galactopyranoside is a chromogenic substrate used for testing enzyme activity. It is commonly used in molecular biology research to detect and measure the activity of β-galactosidase (biosynth: EC03318).
|
-
- HY-N13701
-
|
|
NO Synthase
|
Inflammation/Immunology
|
|
3β,7β,15α-Trihydroxy-4-(hydroxymethyl)-11,23-dioxo-lanost-8-en-26-oic acid is a triterpene compound that can be found in Ganoderma lucidum, and it inhibits nitric oxide (NO) production in BV-2 microglial cells induced by lipopolysaccharide (LPS, HY-D1056), with an IC50 of 4.15 μM .
|
-
- HY-P5892
-
|
|
Opioid Receptor
|
Neurological Disease
|
|
β-Endorphin (1-27) (human) is an opioid antagonist that binds μ-, δ-, and κ-opioid receptors with Kis of 5.31, 6.17, and 39.82 nM, respectively. β-Endorphin (1-27) (human) inhibits β-Endorphin (HY-P1502)-induced and etorphine-induced analgesia [2].
|
-
- HY-N7683
-
|
|
Glycosidase
|
Metabolic Disease
|
|
Prunetin 5-O-β-D-glucopyranoside is an isoflavone isolated from extracts of Potentilla astracanica. Prunetin 5-O-β-D-glucopyranoside is a potent and uncompetitive inhibitor of α-glucosidase, with an IC50 of 56.05 μg/mL. Prunetin 5-O-β-D-glucopyranoside can be used for the research of type-2 diabetes .
|
-
- HY-W854392
-
|
|
Biochemical Assay Reagents
|
|
|
3-Carboxyumbelliferyl-β-D-glucuronide (dipotassium) is a chromogenic substrate with biological activity for enzyme activity detection. 3-Carboxyumbelliferyl-β-D-glucuronide (dipotassium) can be used to evaluate biological reactions associated with glycosidases. 3-Carboxyumbelliferyl-β-D-glucuronide (dipotassium) shows a wide range of application potentials in compound discovery and biomedical research.
|
-
- HY-N12123
-
|
|
Others
|
Others
|
|
Peimisine 3-O-β-D-glucopyranoside (Compound 1) is a steroid alkaloid. Peimisine 3-O-β-D-glucopyranoside can be isolated and purified from natural Fritillaria unibracteata. Peimisine 3-O-β-D-glucopyranoside shows moderate protective effect on rotenone-induced neurotoxicity of PC12 cell line .
|
-
- HY-168593
-
|
|
β-catenin
PROTACs
Histone Demethylase
|
Cancer
|
|
Wnt/β-catenin-IN-5 (Compound 4) is an inhibitor of the Wnt/β-catenin signaling pathway. Wnt/β-catenin-IN-5 eliminates colorectal cancer stem cells and inhibits tumor growth by suppressing the Wnt signaling pathway. PROTACs Wnt/β-catenin-IN-5, which is also a PROTAC based on IOX1, effectively induces the degradation of KDM3A and KDM3B (Target protein ligand (Pink): HY-12304; linker (Black): HY-22335; Conjugate of E3 ligase ligand and linker: HY-112599; E3 ligase (Blue): HY-41547) .
|
-
- HY-150977
-
-
- HY-150976
-
-
- HY-P3831
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
β-Interleukin II (44-56) is a 44-56 fragment of beta-interleukin II polypeptide. Interleukin family are a group of cytokines associated with immune system, mainly expressed by leukocytes .
|
-
- HY-N12997
-
|
|
Others
|
Others
|
|
Torachrysone 8-O-β-D-glucoside is a phenolic glycoside that can be isolated from the seeds of Senna tora. Torachrysone 8-O-β-D-glucoside shows cytotoxicity .
|
-
- HY-N12245
-
|
|
Others
|
Cancer
|
|
Narciclasine-4-O-β-D-glucopyranoside can be isolated from Pancratium maritimum. Narciclasine-4-O-β-D-glucopyranoside has anticancer activity .
|
-
- HY-N2831
-
|
|
Others
|
Others
|
|
Agrimonolide 6-O-β-D-glucoside is a isocoumarin that can be isolated from Agrimonia pilosa. Agrimonolide 6-O-β-D-glucoside is used in hepatic disease research .
|
-
- HY-N9525
-
|
|
Others
|
Others
|
|
Limocitrin 3-β-D-glucose is a flavonoid glycoside .
|
-
- HY-N13309
-
|
|
Others
|
Others
|
|
Torosachrysone 8-O-beta-gentiobioside is a natural product .
|
-
- HY-W039931
-
-
- HY-W008741
-
-
- HY-W339410
-
-
- HY-W013854
-
|
3β-Hydroxy-5α-androstane
|
Endogenous Metabolite
|
Others
|
|
5α-Androstan-3β-ol (Androstan), a saturated sterol, is a CAR (constitutive androstane receptor) inverse agonist ligand. 5α-Androstan-3β-ol (Androstan) increases the AmB-channel conductance in a concentration dependent manner [2].
|
-
- HY-N8021
-
|
(+)-Epipinoresinol-4′′-β-D-glucoside
|
Others
|
Others
|
|
Epipinoresinol-4-O-β-glucoside (Compound 3) is a lignan glucoside that can be isolated from Forsythia suspensa .
|
-
- HY-N11016
-
|
|
Others
|
Others
|
|
1-Methoxymethyl-β-carboline is a natural product isolated from the root of Eurycoma longifolia .
|
-
- HY-160790
-
|
|
ADC Linker
|
Cancer
|
|
β-Glu-PNP is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
|
-
- HY-P1589
-
|
|
β-catenin
|
Cancer
|
|
β-catenin peptide is a 8-aa peptide, and can promote thymocyte positive selection.
|
-
- HY-W699936
-
|
|
Cytochrome P450
|
Others
|
|
6β-Hydroxy androstenedione is a steroid product that can be isolated from Fusarium culmorum .
|
-
- HY-N2075
-
-
- HY-N3358
-
|
|
Others
|
Others
|
|
Lupeol β-hydroxyoctadecanoate is a Triterpenoids product that can be isolated from the roots of Biondia hemsleyana. .
|
-
- HY-N5108
-
|
|
Others
|
Others
|
|
4β,12-Dihydroxyguaian-6,10-diene, a natural terpene, is isolated from the rhizomes of Alisma orientale .
|
-
- HY-163779
-
|
|
Glycosidase
|
Neurological Disease
|
|
β-Glucocerebrosidase modulator 1 (Compound 28) is an allosteric modulator for β-Glucocerebrosidase with an EC50 of 9.0 μM and a Kd of 0.050 μM .
|
-
- HY-N8555
-
|
|
Others
|
Others
|
|
ent-Kaurane-16β,19,20-triol is a Diterpenoids product that can be isolated from the herbs of Euphorbia ehracteolata .
|
-
- HY-113019S
-
-
- HY-133709
-
|
|
Parasite
|
Infection
|
|
β-Aflatrem is an insecticide metabolite from the sclerotium of Aspergillus flavus that exhibits significant activity against the corn borer H. zea .
|
-
- HY-154852
-
|
|
GSK-3
CDK
|
Neurological Disease
|
|
GSK-3 inhibitor 4 is an orally active and brain-penetrant inhibitor of GSK-3, CDK2, and CDK5, with IC50 values of 0.56 nM (GSK-3β), 0.45 nM (GSK-3α), 0.47 μM, and 0.68 μM, respectively. GSK-3 inhibitor 4 effectively reduces the phosphorylation level of Tau protein. GSK-3 inhibitor 4 can be used in Alzheimer's disease (AD) studies .
|
-
- HY-P1363F3
-
|
5-FAM-Amyloid β-peptide (1-42) (human) Tris
|
Amyloid-β
|
Neurological Disease
|
|
5-FAM-β-Amyloid (1-42), human (5-FAM-Amyloid β-peptide (1-42) (human) TFA is a5-FAM labeled β-Amyloid (1-42), human TFA (HY-P1363).
|
-
- HY-N8805
-
|
|
Others
|
Cancer
|
|
Nortrachelogenin-8'-O-β-glucoside is a natural product that can be isolated from the dried roots of Pulsatilla koreana. Nortrachelogenin-8'-O-β-glucoside inhibits cancer cell proliferation and reduces hormone dependence [2].
|
-
- HY-N12067
-
|
|
Others
|
Inflammation/Immunology
|
|
Columbianetin β-D-glucopyranoside can be isolated from Angelicae pubescentis radix and has antiplatelet aggregation, anti-inflammatory and analgesic activities. Columbianetin β-D-glucopyranoside exerts significant protective effects against glutamate-induced toxicity .
|
-
- HY-N1661
-
|
|
Others
|
Others
|
|
2α,3β-Dihydroxypterodontic acid is a natural product used for synthesize 2α,3β-dihydroxy-5,11(13)-dien-eudesman-12-oic acid .
|
-
- HY-160497
-
|
|
PROTAC-Linker Conjugates for PAC
|
Cancer
|
|
MC-(β-Ala)-PABC-(β-D-GlcUA)-amide-PEG1-CH2-CC-885 (Comp Ie) is a neodegrader conjugate, can be used in the synthesis of antibody neoDegrader conjugate (AnDC) .
|
-
- HY-B0452R
-
|
|
Adrenergic Receptor
|
Endocrinology
|
|
Ritodrine (hydrochloride) (Standard) is the analytical standard of Ritodrine (hydrochloride). This product is intended for research and analytical applications. Ritodrine (DU21220) hydrochloride is a potent and orally active β-adrenergic agonist. Ritodrine hydrochloride decreases preterm delivery and uterine contraction. Ritodrine hydrochloride has the potential for the research of preterm labor [2].
|
-
- HY-16294
-
|
|
GSK-3
|
Cancer
|
|
LY2090314 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50 values of 1.5 nM and 0.9 nM for GSK-3α and GSK-3β, respectively.
|
-
- HY-P10704
-
|
|
Integrin
|
Cancer
|
|
C16Y is a short peptide and an inhibitor of integrins αvβ3 and α5β1. C16Y acts on the cell membrane and exerts its anticancer activity by inhibiting angiogenesis .
|
-
- HY-B0320AR
-
|
Disodium Cromoglycate (Standard); FPL-670 (Standard)
|
Calcium Channel
GSK-3
|
Inflammation/Immunology
|
|
Cromolyn (sodium) (Standard) is the analytical standard of Cromolyn (sodium). This product is intended for research and analytical applications. Cromolyn sodium (Disodium Cromoglycate; FPL-670) is an antiallergic agent. Cromolyn sodium is a GSK-3β inhibitor with an IC50 of 2.0 μM.
|
-
- HY-111931
-
|
|
CDK
GSK-3
|
Cancer
|
|
Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of CDK1, CDK5, and GSK-3β with IC50s of 5 nM, 7 nM, and 80 nM, respectively .
|
-
- HY-126402
-
|
|
Integrin
|
Cancer
|
|
Arg-Gly-Asp (RGD) is a synthetic peptide corresponding to the cell adhesion sequence for the integrins αVβ1, αVβ3, αVβ5, αVβ6, αVβ8, α8β1, and α5β1. It is a component of radioligands and peptidomimetics that have been used in the study of integrin expression and activity in vivo.
|
-
- HY-W416278
-
|
Pentyl 2-acetamido-2-deoxy-β-D-glucopyranoside
|
Biochemical Assay Reagents
|
Others
|
|
Pentyl 2-(acetylamino)-2-deoxy-β-D-glucopyranoside (Pentyl 2-acetamido-2-deoxy-β-D-glucopyranoside) is used in glycobiology research.
|
-
- HY-N2142
-
|
|
Others
|
Cancer
|
|
3-O-beta-Allopyranosyl-(1->4)-beta-oleandropyranosyl-11-O-isobutyryl-12-O-acetyltenacigenin B is a chemical constituent of the plant Poria cocos .
|
-
- HY-P1548B
-
|
Human β-CGRP acetate; CGRP-II (Human) (acetate)
|
CGRP Receptor
|
Cardiovascular Disease
Inflammation/Immunology
|
|
β-CGRP, human acetate (Human β-CGRP acetate) is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC50s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells .
|
-
- HY-137522S
-
|
3'-Azido-3'-deoxythymidine β-D-glucuronide-d3 sodium
|
Isotope-Labeled Compounds
Drug Metabolite
|
Others
|
|
Zidovudine O-β-D-glucuronide-d3 (sodium) (3'-Azido-3'-deoxythymidine β-D-glucuronide-d3 (sodium)) is a deuterium labeled Zidovudine O-β-D-glucuronide (sodium) (HY-137522). Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the major metabolite of Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection [2] [3].
|
-
- HY-N10741
-
|
|
Xanthine Oxidase
Bacterial
|
Infection
|
|
Ellagic acid 4-O-β-D-xylopyranoside is a natural ellagitannin with antimicrobial activity. Ellagic acid 4-O-β-D-xylopyranoside is an xanthine oxidase inhibitor with an 50 of 2.1 μg/mL .
|
-
- HY-N7755
-
|
|
Estrogen Receptor/ERR
|
Cancer
|
|
Estradiol 3-(β-D-Glucuronide) sodium is the glucuronic acid derivative of estradiol (HY-B0141). Estradiol 3-(β-D-Glucuronide) sodium is radiolabeled for use in tumor imaging and biodistribution studies .
|
-
- HY-128974
-
|
Lauryl Maltoside
|
DNA/RNA Synthesis
|
Others
|
|
N-Dodecyl-β-D-maltoside (Lauryl Maltoside) is a non-ionic detergent. N-Dodecyl-β-D-maltoside has strong adsorption on alumina, titanium dioxide and hematite. N-Dodecyl-β-D-maltoside can promote the reactivation of various proteins. N-Dodecyl-β-D-maltoside can effectively stabilize photoactive reaction center complexes (RCs) and inhibit the degradation of Rhodopseudomonas spheroides R-26 reaction center in solution. N-Dodecyl-β-D-maltoside can be used for purification and stabilization of RNA polymerase and for detection of protein-lipid interactions [2] [3] .
|
-
- HY-N3661
-
|
|
Bacterial
|
Infection
|
|
(24S)-Cycloartane-3β,24,25-triol, a cycloartane, has antitubercular activity against Mycobacterium tuberculosis H37Rv (MIC: 32 μg/mL). (24S)-Cycloartane-3β,24,25-triol can be isolated from the flowers of Chrysanthemum morifolium .
|
-
- HY-P1363B
-
|
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (1-42), human, HFIP-treated is a β-Amyloid (1-42), human (HY-P1363A) treated with HFIP. β-Amyloid (1-42), human (Amyloid β-Peptide (1-42) (human)) is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease [2] [3].
|
-
- HY-P4882
-
|
|
Amyloid-β
|
Neurological Disease
|
|
(Pyr3)-Amyloid β-Protein (3-42) is the predominant amyloid β-peptide structure deposited in human brain of Alzheimer's disease and Down's syndrome patients. (Pyr3)-Amyloid β-Protein (3-42) is suggested to accumulate in the brain and to trigger the formation of insoluble amyloid β-peptide deposits .
|
-
- HY-163363
-
|
|
Adrenergic Receptor
|
Cancer
|
|
β-AR antagonist 2 (compound 43) is an antagonist of β-AR (IC50: 0.17 μM). β-AR-IN-1 inhibits the growth of mouse A549 xenograft tumors and shows cardioprotective efficacy against DOX-induced HF in C57 mice .
|
-
- HY-W142692
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Dodecyl β-D-glucopyranoside is a non-ionic detergent and surfactant commonly used to solubilize and purify membrane proteins in biochemical research. Dodecyl β-D-glucopyranoside also interacts with bovine serum albumin (BSA) to quench its intrinsic fluorescence. The critical micelle concentration (CMC) of Dodecyl β-D-glucopyranoside (DG) and DG/BSA complex is 2.0 mM and 2.34 mM, respectively. Micelles can be formed in aqueous solutions above this concentration .
|
-
- HY-126107
-
-
- HY-N1905
-
|
|
Others
|
Others
|
|
4-Methoxy-β-carboline-1-carboxylic acid methylester is an alkaloid with the structure of canthin-6-one and β-carboline .
|
-
- HY-D1224A
-
-
- HY-171031
-
|
|
GSK-3
Apoptosis
Caspase
Bcl-2 Family
Reactive Oxygen Species
|
Neurological Disease
|
|
TFGF-18 is a GSK-3β inhibitor (IC50: 0.59 μM). TFGF-18 inhibits LPS-induced microglia activation and proinflammatory mediators release via inhibiting GSK-3β and downstream p65/NF-κB signaling. TFGF-18 inhibits neuronal apoptosis and oxidative stress, inhibits expressions of Bax, caspase3 and cleaved-caspase3 and increases the expression of Bcl-2. TFGF-18 has neuroprotection effect, inhibit neuroinflammation and attenuates cognitive impairment [2].
|
-
- HY-N0520R
-
|
|
Reactive Oxygen Species
|
Others
|
|
Calycosin-7-O-β-D-glucoside (Standard) is the analytical standard of Calycosin-7-O-β-D-glucoside. This product is intended for research and analytical applications. Calycosin-7-O-β-D-glucoside is an isoflavone isolated from Astragali Radix. Calycosin-7-O-β-D-glucoside has variety of biological activities, such as neuroprotective, cardioprotection, anti-inflammation, and antioxidative stress effects [2].
|
-
- HY-W559353
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
1-(3-Beta-amino-2,3-dideoxy-beta-d-threopenta-furanosyl)thymine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
|
-
- HY-P1363
-
|
Amyloid β-peptide (1-42) (human) TFA
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (1-42), human TFA (Amyloid β-Peptide (1-42) (human) TFA) is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease [2] [3].
|
-
- HY-N2929
-
|
|
Glycosidase
|
Cardiovascular Disease
|
|
β-Hydroxypropiovanillone, a natural compound, shows significant concentration-dependent inhibitory effects on α-glucosidase with an IC50 of 257.8 μg/mL .
|
-
- HY-N1616
-
|
|
Apoptosis
|
Others
|
|
1β-Hydroxyeuscaphic acid has significant hepatoprotective activity by lowering the leakage of intracellular enzymes, reducing the oxidation of proteins and decreasing the incidence of apoptosis .
|
-
- HY-N9201
-
|
|
Others
|
Others
|
|
8beta-Methoxyatractylenolide I is a Sesquiterpenoids product that can be isolated from the rhizomes of Atractylodes macrocephala. .
|
-
- HY-N7559
-
|
|
Others
|
Others
|
|
7β-Acetoxytaxuspine C is a Diterpenoids product that can be isolated from the needles of Taxus canadensis. .
|
-
- HY-N2820
-
|
|
Others
|
Others
|
|
Adynerigenin beta-neritrioside is a Steroids product that can be isolated from the herbs of Nerium indicum Mill. .
|
-
- HY-137919
-
-
- HY-138322
-
|
|
ADC Linker
|
Cancer
|
|
N-trifluoroacetyl-β-alanyl chloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
|
-
- HY-137940
-
|
Gentiobiose
|
Others
|
Others
|
|
β-Gentiobiose (Gentiobiose) is a naturally occurring oligosaccharin with a rapid turnover rate in ripening tomato fruit .
|
-
- HY-W114954
-
|
|
Bacterial
|
Inflammation/Immunology
|
|
Guaiacylglycerol-beta-guaiacyl ether is a model compound of lignin monomers that can be degraded by Bacillus amyloliquefaciens CotA .
|
-
- HY-N12034
-
|
|
Others
|
Others
|
|
Picropodophyllin-β-D-glucoside (compound 3) is a podophyllotoxin glucoside isolated from Chinese medicinal plants .
|
-
- HY-N8143
-
-
- HY-N13348
-
|
|
Others
|
Others
|
|
Emodin-8-O-beta-gentiobioside is a natural product .
|
-
- HY-W357152
-
-
- HY-W014505
-
-
- HY-W274569
-
-
- HY-N13419
-
|
|
Others
|
Others
|
|
3β-Isodihydrocadambine 4-oxide is a natural product .
|
-
- HY-137232
-
-
- HY-48959
-
|
|
Integrin
|
Metabolic Disease
|
|
α7β1 integrin modulator-1 is a potent α7β1 integrin modulator. α7β1 integrin modulator-1 has the potential for the research of muscular dystrophy .
|
-
- HY-P0031
-
|
|
Integrin
|
Others
|
|
Cyclo(RADfK) is a selective α(v)β(3) integrin ligand that has been extensively used for research, therapy, and diagnosis of neoangiogenesis.
|
-
- HY-P5124
-
|
KLVFF
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid peptide(16-20) is a amino acid sequences (KLVFF) of Amyloid-β (Abeta). β-Amyloid peptide(16-20) is an effective inhibitor of Abeta fibril formation, with RG-/-GR-NH2 residues added at N- and C-terminal ends to aid solubility) .
|
-
- HY-169238
-
|
|
17β-HSD
|
Metabolic Disease
|
|
17β-HSD7-IN-1 (compound 4) is an inhibitor of 17β-HSD7, with inhibitory effect agasint the formation of Estradiol (IC50=63?nM). .
|
-
- HY-N8102
-
|
|
Transmembrane Glycoprotein
Others
|
Cardiovascular Disease
|
|
Echinocystic acid 28-O-β-D-glucoside is a metabolite of Echinocystic acid by microbial oxidation and glucosidation. Echinocystic acid 28-O-β-D-glucoside is a tissue factor pathway inhibitor, with an IC50 of 10.61 nM .
|
-
- HY-P2283
-
|
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (1-37) (human) correlates moderately with Mini-Mental State Examination (MMSE) scores in Alzheimer disease. β-Amyloid (1-37) (human) possesses an added diagnostic value .
|
-
- HY-132382S
-
-
- HY-14302
-
|
GR33343X
|
Adrenergic Receptor
|
Inflammation/Immunology
Endocrinology
|
|
Salmeterol (GR33343X) is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively .
|
-
- HY-N4201
-
|
|
EGFR
Src
|
Cancer
|
|
Beta-hydroxyisovalerylshikonin is a natural product isolated from Lithospermum erythrorhizon, acts as a potent inhibitor of protein tyrosine kinases (PTK), with IC50s of 0.7μM and 1μM for EGFR and v-Src receptor, respectively. Beta-hydroxyisovalerylshikonin is effective against a wide variety of tumor cell lines, and most efficiently induces cell-death in NCI-H522 and DMS114 cells .
|
-
- HY-139413
-
|
|
Toll-like Receptor (TLR)
|
Cancer
|
|
β-D-glucan is a natural non-digestible polysaccharide and high biocompatibility that can be selectively recognized by recognition receptors such as Dectin-1 and Toll-like receptors as well as being easily internalized by murine or human macrophages, which is likely to attribute to a target delivery . β-d-glucan is an enteric delivery vehicle for probiotics [2].
|
-
- HY-N12978
-
|
|
Others
|
Cancer
|
|
Benzyl β-gentiobioside is a phenyl alcohol glycoside found in peach kernels (Prunus persica seeds). Benzyl β-gentiobioside has anti-tumor promoting activity by inhibiting TPA (12-O-tetradecanoylphorbol 13-acetate, a tumor promoter)-induced Epstein-Barr virus early antigen (EBV-EA) activation .
|
-
- HY-P3859
-
|
|
Amyloid-β
|
Neurological Disease
|
|
Cys-Gly-Lys-Arg-Amyloid β-Protein (1-42) is a peptide fragment of amyloid β-protein (Aβ). Cys-Gly-Lys-Arg-Amyloid β-Protein (1-42) can be used in research of Alzheimer's disease .
|
-
- HY-N7598
-
|
|
Monoamine Oxidase
|
Neurological Disease
|
|
Chrysophanol-1-O-β-gentiobioside, an anthraquinone glycoside isolated from Cassia obtusifolia seeds. Chrysophanol-1-O-β-gentiobioside shows selective inhibition of hMAO-A isozyme activity (IC50=96.15 μM) .
|
-
- HY-W587861
-
|
5βDHP
|
Oxytocin Receptor
|
Endocrinology
|
|
5β-Dihydroprogesterone (5βDHP) is the metabolite of Progesterone (HY-N0437). 5β-Dihydroprogesterone binds to oxytocin receptor, reduces the Oxytocin (HY-17571)-induced calcium signal transduction, thereby exhibiting the tocolytic activity .
|
-
- HY-142441
-
|
|
Thyroid Hormone Receptor
|
Endocrinology
|
|
THR-β Agonist 1 is a potent and selective agonist of THRβ. Thyroid hormone receptor mediates the physiological activity of thyroid hormones which plays a key role in normal growth and development of the body and in maintaining metabolic balance. THR-β Agonist 1 has the potential for the research of thyroid hormone receptor-related diseases (extracted from patent WO2021104288A1, compound 2) .
|
-
- HY-168130
-
|
|
TNF Receptor
Interleukin Related
|
Cardiovascular Disease
|
|
TNF-α/IL-1β-IN-1 (compund 11a) is an anti-inflammatory agent that reduces the expression of TNF-α and IL-1β, inhibits oxidative stress and cardiomyocyte apoptosis, has good activity against septic myocardial injury, and improves myocardial blood supply in vivo .
|
-
- HY-N2182R
-
|
|
Others
|
Inflammation/Immunology
|
|
Episyringaresinol 4'-O-β-D-glncopyranoside (Standard) is the analytical standard of Episyringaresinol 4'-O-β-D-glncopyranoside. This product is intended for research and analytical applications. Episyringaresinol 4'-O-β-D-glncopyranoside (compound 22), isolated from Alhagi sparsifolia Shap, is a natural potential neuroinflammatory inhibitor .
|
-
- HY-N0171A
-
-
- HY-E70139
-
|
EC:2.4.1.313; B3GALNT2; β-1,3-N-acetylgalactosaminyltransferase II
|
Glucosylceramide Synthase (GCS)
|
Others
|
|
UDP-GalNAc:β-1,3-N-acetylgalactosaminyltransferase 2 ( EC:2.4.1.313; B3GALNT2; β-1,3-N-acetylgalactosaminyltransferase II) is a glycosyltransferase
.
|
-
- HY-149727
-
|
|
Adrenergic Receptor
|
Metabolic Disease
|
|
β2AR agonist 2(compound 8a) is a β2 -Adrenergic receptor (β2AR) agonist. β2AR agonist 2 is a saturated nitrogen ring compound containing 4- to 7-membered heterocycle. β2AR agonist 2 has a chiral structure (the -R form) by carrying carbon containing the essential hydroxyl, thereby enhancing cellular glucose uptake (GU) activity and significantly stimulating glucose uptake by skeletal muscle cells. β2AR agonist 2 can be used in the study of Type 2 Diabetes (T2D) .
|
-
- HY-155379
-
|
|
Virus Protease
|
Infection
|
|
β-Herpesvirus protease-IN-1 (compound 19) is a β-herpesvirus protease inhibitor with IC50s of 2.5 μM and 0.33 μM for HCMVPro and HHV6Pro, respectively .
|
-
- HY-N1111
-
|
6β,19α-Dihydroxyursolic acid
|
HIV
|
Infection
|
|
Uncaric acid (6β,19α-Dihydroxyursolic acid) (compound 6) is a triterpene that can be found in Eriobotrya japonica. Uncaric acid shows anti HIV-1, HRV 1B, SNV activity .
|
-
- HY-137845
-
|
|
Fluorescent Dye
|
Others
|
|
4-Methylumbelliferyl β-D-galactopyranoside is a fluorescent substrate for β-galactosidase which, when cleaved, produces a water-soluble blue fluorescent coumarin fluorophore that can be detected using a fluoroenzymeter or fluorometer .
|
-
- HY-N6677
-
|
Apocarotenal
|
Cytochrome P450
|
Cancer
|
|
β-Apo-8'-carotenal (Apocarotenal), a provitamin A carotenoid, is an inducer of CYPlA1 and CYPlA2 in rat. β-Apo-8'-carotenal is present in many fruits and vegetables .
|
-
- HY-B0141S
-
|
β-Estradiol-d3; 17β-Estradiol-d3; 17β-Oestradiol-d3
|
Estrogen Receptor/ERR
Endogenous Metabolite
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Endocrinology
Cancer
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Estradiol-d3 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.
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- HY-W250196
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Nonyl-beta-D-1-thiomaltoside
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Biochemical Assay Reagents
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Others
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Nonyl-β-D-1-thiomaltoside is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-P10783
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Peptide-Drug Conjugates (PDCs)
Integrin
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Cancer
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BGC0222 is a novel prodrug of Irinotecan (HY-16562). BGC0222, as a PEG-cRGD-conjugated Irinotecan (HY-16562) derivative, could slowly and steadily release Irinotecan (HY-16562). BGC0222 binds to αVβ3 with IC50 values of 4.25 μM (αVβ3) and 58.7 μM (αVβ5). BGC0222 possesses the property of inducing neovascularization. BGC0222 exhibits good antiproliferation activity in many tumors .
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- HY-B1803A
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ICI 136753 hydrochloride
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GABA Receptor
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Neurological Disease
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Tracazolate (ICI 136753) hydrochloride is a potent GABAA receptor modulator. Tracazolate hydrochloride has selectivity for β3 and potentiates α1β1γ2s (EC50=13.2 μM), α1β3γ2 (EC50=1.5 μM). Tracazolate hydrochloride has the potency (EC50) determined by the nature of the third subunit (γ1-3, δ, ε) within the receptor complex. Tracazolate hydrochloride possesses anxiolytic and anticonvulsant activity [2].
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- HY-N12078
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Biochemical Assay Reagents
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Cancer
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4-Chloro-3-methoxy-5-methylphenyl 6-O-(6-deoxy-β-L-mannopyranosyl)-β-D-glucopyranoside (compound 3) is an anticancer agent and natural product that can effectively inhibit lung cancer proliferation of A549 cells. 4-Chloro-3-methoxy-5-methylphenyl 6-O-(6-deoxy-β-L-mannopyranosyl)-β-D-glucopyranoside is available from Lilium regale and has potential for use in cancer research .
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- HY-155705
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TGF-β Receptor
GSK-3
β-catenin
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Others
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BMP agonist 1 (compound 2 b) is a small-molecule agonist of bone morphogenic protein (BMP). BMP induces C2C12 cell differentiation with BMP and highly depends on active BMP signaling. BMP agonist 1 inhibits GSK3β, increases β-catenin signaling and synergistically regulates Id2and Id3 expression. BMP agonist 1 is used in diseases and defects of the skeleton research .
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- HY-161751
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GSK-3
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Cancer
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MJ34 is a potent inhibitor of GSK-3β and GSK-3α, with the IC50s of 15.4 nM and 31.5 nM, respectively. MJ34 plays an important role in cancer research
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- HY-P5945
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- HY-144259
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Beta-lactamase
Bacterial
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Infection
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Metallo-β-lactamase-IN-4 (compound 40) is a potent metallo-β-lactamases (MBL) inhibitor, with IC50 values of 0.1 μM (VIM-1), 1.3 μM (NDM-1), and 5.0 μM (IMP-7), respectively .
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- HY-N0097A
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AraG
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Drug Derivative
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Cancer
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9-β-D-Arabinofuranosylguanine is a Guanosine (HY-N0097) analog and shows high affinity for deoxyguanosine kinase (dGK) with a Km of 8.0 μM. 9-β-D-Arabinofuranosylguanine can be used for the research of T-cell lymphoblastic disease [2].
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- HY-W020795
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Biochemical Assay Reagents
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Others
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Hexadecyl β-D-maltoside is the anomer of Hexadecyl α-d-maltoside. Hexadecyl β-D-maltoside is different from Hexadecyl α-d-maltoside, showing non-Newtonian behavior, including thixotropic behavior, shear-thinning, and viscoelastic behavior .
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- HY-144262
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Beta-lactamase
Bacterial
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Infection
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Metallo-β-lactamase-IN-4 (compound 40) is a potent metallo-β-lactamases (MBL) inhibitor, with IC50 values of 0.5 μM (VIM-1), 2.1 μM (NDM-1), and 3.3 μM (IMP-7), respectively .
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- HY-N0406
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P-glycoprotein
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Inflammation/Immunology
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2"-O-beta-L-galactopyranosylorientin is extracted from the flowers of Trollius ledebouri. 2"-O-beta-L-galactopyranosylorientin involves transporter mediated efflux in addition to passive diffusion and is the substrate of multidrug resistance protein 2 (MRP2). Anti-inflammatory effect [2] [3].
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- HY-137816
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β-glucuronidase
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Others
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6-Chloro-3-indolyl-β-D-glucuronide cyclohexylammonium salt is a chromogenic substrate for β-glucuronidase. 6-Chloro-3-indolyl-β-D-glucuronide cyclohexylammonium salt produces a salmon colored precipitate upon cleavage .
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- HY-N5094
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Others
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Others
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6'-O-β-Apiofuranosylsweroside is a secoiridoid glycoside that can be isolated from the leaves of Lonicera angustifolia Wall .
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- HY-N11631
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Others
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Others
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1-O-trans-Cinnamoyl-β-D-glucopyranose is a nature product. 1-O-trans-Cinnamoyl-β-D-glucopyranose can be isolated from fruits .
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- HY-P2562
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Amyloid-β
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Neurological Disease
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β-Amyloid (1-38), mouse, rat is composed of 38 aa (1-38 residues of the Aβ peptide) and is the primary component of the amyloid plaques of Alzheimer’s disease .
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- HY-W288676
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Biochemical Assay Reagents
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Others
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6-Fluoro-3-indolyl-β-D-galactopyranoside is a chromogenic enzyme substrate commonly used in microbiology to detect the expression of β-galactosidase in bacterial colonies.
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- HY-W015546R
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Bacterial
mGluR
PKC
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Neurological Disease
Inflammation/Immunology
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Clenbuterol (Standard) is the analytical standard of Clenbuterol. This product is intended for research and analytical applications. Clenbuterol (NAB-365) is a β2-adrenergic receptor agonist with an EC50 of 31.9 nM . Clenbuterol is a very potent inhibitor of the lipopolysaccharide (LPS)-induced release of TNF-α and IL-1β. Clenbuterol can inhibit the inflammatory process. Clenbuterol is a bronchodilator [2].
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- HY-P5810
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CcoTx2; β-TRTX-cm1b
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Sodium Channel
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Neurological Disease
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Ceratotoxin-2 (CcoTx2) is a voltage-gated sodium channel blocker with IC50s of 8 nM and 88 nM against Nav1.2/β1 and Nav1.3/β1, respectively .
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- HY-P0265AS
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Amyloid beta-Peptide-15N (1-40) (human) TFA; Amyloid β-Peptide-15N (1-40) (human) TFA
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Amyloid-β
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Neurological Disease
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β-Amyloid- 15N (1-40) (TFA) is the 15N-labledβ-Amyloid (1-40) (TFA). β-Amyloid (1-40) is a primary protein in plaques found in the brains of patients with Alzheimer's disease[1].
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- HY-133972
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- HY-N10525
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- HY-P3781
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Amyloid-β
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Neurological Disease
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(Met(O)35)-Amyloid β-Protein (1-42) is the oxidation form of Met35 in Aβ42. (Met(O)35)-Amyloid β-Protein (1-42) can yield an oligomer size distribution characteristic of Aβ40. (Met(O)35)-Amyloid β-Protein (1-42) can be used in the research of Alzheimer’s disease (AD) .
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- HY-P1362FA
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Cy5-Amyloid β Peptide (42-1)(human) Tris
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Amyloid-β
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Neurological Disease
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Cy5-β-Amyloid (42-1), human is a Cy5 fluorescently-labelled β-Amyloid (42-1, human) peptide (λex= 633 nm and λem= 670 nm) .
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- HY-143414
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Beta-lactamase
Bacterial
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Infection
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Metallo-β-lactamase-IN-6 is a potent VIM-Type metallo-β-lactamase inhibitor with IC50s of 0.56 μM, 29.50 μM and 5.78 μM for VIM-2, VIM-1 and VIM-5. Metallo-β-lactamase-IN-6 displays potent synergistic antibacterial activity with Meropenem against engineered Escherichia coli strains and intractable clinically isolated Pseudomonas aeruginosa producing VIM-2 MBL .
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- HY-N5129
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Others
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Others
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Genistein 7-O-β-D-glucopyranoside-4'-O-[α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside] is an isoflavone triglycoside that could be isolated from Sophora japonica .
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![Genistein 7-O-β-D-glucopyranoside-4'-O-[α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside]](//file.medchemexpress.com/product_pic/hy-n5129.gif)
- HY-N12077
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Parasite
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Infection
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Eurycomanol 2-O-β-D-glucopyranoside (compound 4) is a natural product that can be obtained from Eurycoma longifolia. Eurycomanol 2-O-β-D-glucopyranoside has the potential for anti-malarial research .
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- HY-N12856
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Others
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Others
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Cyclo-olivil-9-O-β-glucopyranoside can be isolated from the root of Urtica triangularis HAND-MASS. Cyclo-olivil-9-O-β-glucopyranoside can be used in the drug development .
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- HY-160788
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- HY-N3523
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Others
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Cancer
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3-O-Beta-D-Glucopyranosylplatycodigenin is an oleanane-type triterpenoid isolated from roots of Platycodon grandiflorum. 3-O-Beta-D-Glucopyranosylplatycodigenin exhibits anti-proliferative activities against HSC-T6 cell line with an IC50 of 13.36 μM .
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- HY-P99274
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BI 836845; Anti-Human IGF1 and IGF2 Recombinant Antibody
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IGF-1R
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Cancer
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Xentuzumab (Anti-Human IGF1 and IGF2 Recombinant Antibody; BI836845) is a recombinant a human monoclonal antibody that targets IGF ligands IGF1 and IGF2. Xentuzumab inhibits both of IGF1 and IGF2 growth-promoting signalling and suppresses AKT activation .
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- HY-N8788
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Others
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Inflammation/Immunology
Cancer
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Baicalein 7-O-β-D-ethylglucuronide is a natural flavone glycoside that can be extracted from Scutellaria baicalensis Georgi. Baicalein 7-O-β-D-ethylglucuronide has antioxidant activity. Baicalein 7-O-β-D-ethylglucuronide inhibits FeSO4-Cys-induced lipid peroxidation of liver homogenate. Baicalein 7-O-β-D-ethylglucuronide also shows strong cytoprotective effect on H2O2-induced oxidative damage of human umbilical vein endothelial cells [2].
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- HY-139702
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Integrin
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Cancer
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α5β1 integrin agonist-1, acting as α5β1 integrin agonist, is able to selectively deliver 5-FU into tumor cells, successfully leading to cancer cell death.
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- HY-161087
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β-catenin
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Cancer
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β-catenin/BCL9 PPI-IN-1 (compound B4) is a potent inhibitor of β catenin/B-Cell lymphoma 9 protein?protein interaction (β catenin/BCL9 PPI) with the IC50 value of 2.25 μM .
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- HY-N6986
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Liquiritigenin-7-apiosylglucoside
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Others
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Cancer
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Liquiritigenin-7-O-β-D-glucopyranosyl-(1→2)-β-D-apiofuranoside (Liquiritigenin-7-apiosylglucoside) is a flavonoid isolated from the roots of Glycyrrhiza, has weaker cytotoxicity against several tumor cells and normal cells .
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- HY-P1363S
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Amyloid β-peptide-15N (1-42) (human) TFA
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Amyloid-β
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Neurological Disease
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β-Amyloid- 15N (1-42), human (TFA) is the 15N-labledβ-Amyloid (1-42) (TFA). β-Amyloid (1-42), human TFA (Amyloid β-Peptide (1-42) (human) TFA) is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease[1].
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- HY-W722177
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- HY-170743
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- HY-W283245
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- HY-W569842
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- HY-W009472
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- HY-W283166
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- HY-153060
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- HY-W144276
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- HY-122813S1
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- HY-W850994
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Tridecyl beta-D-maltopyranoside
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Biochemical Assay Reagents
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Others
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Tridecyl β-D-maltopyranoside is a synthetic sugar, modified by fluorination and methylation. Carbohydrates can be used for the synthesis of glycosylated proteins (biosynth: W-204093).
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- HY-151201
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Steroid Sulfatase
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Cancer
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Steroid sulfatase/17β-HSD1-IN-3 (compound 19) is a dual inhibitor of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1 (17β HSD1). Steroid sulfatase/17β-HSD1-IN-3 irreversibly inhibits hSTS activity with anIC50 value of 27 nM. Steroid sulfatase/17β-HSD1-IN-3 can be used in the study of endometriosis and other estrogen-dependent diseases .
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- HY-151202
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Steroid Sulfatase
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Cancer
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Steroid sulfatase/17β-HSD1-IN-4 (compound 37) is a dual inhibitor of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1 (17β HSD1). Steroid sulfatase/17β-HSD1-IN-4 irreversibly inhibits hSTS activity with anIC50 value of 63 nM. Steroid sulfatase/17β-HSD1-IN-4 can be used in the study of endometriosis and other estrogen-dependent diseases .
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- HY-E70079
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CBL
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Biochemical Assay Reagents
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Infection
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Cystathionine β-lyase, Recombinant Microorganisms (CBL) is an enzyme that catalyzes the breakdown of cystathionine to homocysteine, the penultimate step in methionine biosynthesis. Cystathionine β-lyase is important for bacterial virulence .
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- HY-P2550
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Amyloid-β
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Neurological Disease
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β-Amyloid (1-40), FAM-labeled is a FAM fluorescently-labelled?β-Amyloid (1-40) peptide (λex=?492?nm and λem=?518?nm) .
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- HY-N9121
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Others
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Others
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8β-(4-Acetoxy-5-hydroxytigloyloxy)costunolide (compound 5) is a sesquiterpene lactone that can be isolated from Stevia alpina var. glutinosa .
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- HY-114392
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![(3β)-3-[(O-β-D-Glucopyranosyl-(1→3)-O-6-deoxy-α-L-mannopyranosyl-(1→2)-α-L-arabinopyranosyl)oxy]olean-12-en-28-oic acid](http://file.medchemexpress.com/product_pic/hy-n6058.gif)
![[Ala28]-β Amyloid(25-35)](http://file.medchemexpress.com/product_pic/hy-p5968.gif)
![Naphtho[1,2-b]furan, 2-propenoic acid deriv.](http://file.medchemexpress.com/product_pic/hy-n2767.gif)
![Periplogenin 3-[O-β-glucopyranosyl-(1→4)-β-sarmentopyranoside]](http://file.medchemexpress.com/product_pic/hy-n5053.gif)
![3-O-β-D-Glucopyranosyl(1→2)-[a-Lrhamnopyranosyl(1→3)]-β-D-glucopyranosyl 28-O-β-D-glucuronopyranoside](http://file.medchemexpress.com/product_pic/hy-n9521.gif)
![Luteolin 7-O-[β-D-apiofuranosyl-(1→6)]-β-D-glucopyranoside](http://file.medchemexpress.com/product_pic/hy-n13142.gif)
![Gal[246Bn]β(1-4)Glc[236Bn]-β-MP](http://file.medchemexpress.com/product_pic/hy-w145620.gif)
![Gal[26Bn]β(1-4)Glc[236Bn]-β-MP](http://file.medchemexpress.com/product_pic/hy-w145594.gif)
![Heraclenol 3'-O-[beta-D-apiofuranosyl-(1-6)-beta-D-glucopyranoside]](http://file.medchemexpress.com/product_pic/hy-n8982.gif)
![Gal[236Bn]β(1-4)Glc[236Bn]-β-MP](http://file.medchemexpress.com/product_pic/hy-w145559.gif)
![L-Borneol 7-O-[β-D-apiofuranosyl-(1→6)]-β-D-glucopyranoside](http://file.medchemexpress.com/product_pic/hy-n5137.gif)
![5,6-Bis(4-methoxyphenyl)-2,3-diphenylthieno[3,2-b]furan](http://file.medchemexpress.com/product_pic/hy-18688.gif)
![Galβ(1-3)[Neu5Acα(2-6)]GlcNAc-β-pNP](http://file.medchemexpress.com/product_pic/hy-w145622.gif)
![GlcNAcβ(1-3)[GlcNAcβ(1-6)]GalNAc-α-Thr](http://file.medchemexpress.com/product_pic/hy-w145539.gif)
![Genistein 7-O-β-D-glucopyranoside-4'-O-[α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside]](http://file.medchemexpress.com/product_pic/hy-n5129.gif)
