Search Result
Results for "
ActiveIL-1 beta Inhibitors
" in MedChemExpress (MCE) Product Catalog:
7297
Inhibitors & Agonists
552
Biochemical Assay Reagents
526
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-P5189A
-
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Endogenous Metabolite
Cholinesterase (ChE)
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Others
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His-D-beta-Nal-Ala-Trp-D-Phe-Lys-NH2 TFA, is a growth hormone releasing peptide, as well as a metabolite of GHRP-1. GHRP-1, or Ala-His-D-beta Nal-Ala-Trp-D-Phe-Lys-NH2, has the effect of promoting the release of growth hormone (GH). GHRP-1 increases GH release and increases [Ca2+]i levels in static monolayer cells of rat pituitary gland, but does not affect cAMP levels [1].
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- HY-123495
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- HY-P5542
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- HY-N5112
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(Rac)-β,β-Dimethylacrylalkannin; (Rac)-β,β-Dimethylacrylshikonin
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HIF/HIF Prolyl-Hydroxylase
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Others
Cancer
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(Rac)-Arnebin 1 ((Rac)-β,β-Dimethylacrylalkannin) is the racemate of β,β-Dimethylacrylalkannin and/or β,β-Dimethylacrylshikonin. β,β-Dimethylacrylalkannin and β,β-Dimethylacrylshikonin are napthoquinones isolated from Arnebia nobilis. β,β-Dimethylacrylshikonin has anti-tumor activity [1].
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- HY-107509
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mGluR
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Neurological Disease
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LY2389575 hydrochloride is a selective and noncompetitive mGlu3 negative allosteric modulator (NAM), with an IC50 value of 190 nM. LY2389575 hydrochloride induces an increase in Mrc1 levels. LY2389575 hydrochloride also independently amplifies Amyloid beta (Aβ) toxicity and can be used in study of Alzheimer's disease [1] .
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- HY-P4288
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Amino Acid Derivatives
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Others
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Beta-Asp-His is a dipeptide containing aspartic acid and histidine, which can form amino acid derivatives by complexing with Zinc [1].
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- HY-108790
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Peginterferon β-1a
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Apoptosis
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Neurological Disease
Cancer
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Peginterferon beta-1a (Peginterferon β-1a) is the first pegylated interferon beta-1a molecule. Peginterferon beta-1a induces cancer cells apoptosis and shows anti-tumor activities in nude mice models. Peginterferon beta-1a can be used for the research of cancer and multiple sclerosis (RMS) [1].
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- HY-148533
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mAChR
Adrenergic Receptor
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Neurological Disease
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β2AR agonist /M-receptor antagonist-1 is a potent dual muscarinic antagonist/beta 2 agonist (MABA). β2AR agonist /M-receptor antagonist-1 potently relaxes either Carbachol (HY-B1208)-induced contraction, in the absence (MABA) or presence of Propranolol (M3; HY-B1208), or Histamine (HY-B1204)-induced contraction (β2) [1] .
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- HY-127010
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-
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- HY-W721582
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Glycosidase
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Others
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β,β-Trehalose is a analog of trehalose. β,β-Trehalose can support the growth of shoot tips of Cuscuta. β,β-Trehalose can be cleaved by nonspecific β-glucosidase [1].
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- HY-113887A
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11β-PGF1β
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Drug Isomer
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Endocrinology
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11β-Prostaglandin F1β (11β-PGF1β) is a stereoisomer of PGF1α with inverted C-9 and C-11 hydroxyl groups [1].
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- HY-N10163
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(+)-1β,10β-Epoxydesacetoxymatricarin
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Others
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Others
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1β,10β-Epoxydesacetoxymatricarin is a sesquiterpenoids that can be isolated from Carthamus oxycantha [1].
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- HY-N10750
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Others
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Others
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1α, 2α-Diacetoxy-8β-isobutanoyloxy-9α-benzoyloxy-15-β-(β-furancarbonyloxy)-4β, 6β-dihydroxy-β-dihydroagarofuran (compound 7) is an eudesmane-type sesquiterpenoid that can be founfd in the the root bark of Pseudolarix kaempferi [1].
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- HY-N0988
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Others
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Cancer
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1β,4β,7α-Trihydroxyeudesmane (compound 4) is a nature product that could be isolated from the rhizomes of Homalomena occulta. 1β,4β,7α-Trihydroxyeudesmane has antiproliferative active. 1β,4β,7α-Trihydroxyeudesmane can be used in research of cancer [1].
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- HY-146776S
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- HY-107324
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(-)-β-Elemene; Levo-β-elemene
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Apoptosis
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Cancer
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β-Elemene ((-)-β-Elemene; Levo-β-elemene) is isolated from natural plant Curcuma aromatica with an antitumor activity. β-Elemene can induce cell apoptosis.
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- HY-130502
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Cholesterol 5beta,6beta-epoxide
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Biochemical Assay Reagents
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Others
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5β,6β-epoxycholestanol is an oxidative metabolite of cholesterol formed by free-radical and non-radical oxidation of cholesterol at the 5,6 double bond. Induces lactate dehydrogenase (LDH) release and apoptosis in macrophage-differentiated U937 cells. Cholesterol 5beta,6beta-epoxide has been found in human fatty streaks and advanced atherosclerotic lesions, but not in normal aortic tissue [1] .
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- HY-139137
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AGGC
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DNA Methyltransferase
Integrin
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Cancer
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N-Acetyl-S-geranylgeranyl-L-cysteine is a Methyltransferase inhibitor. N-Acetyl-S-geranylgeranyl-L-cysteine inhibits beta 2 integrin-induced actin polymerization with an IC50 of 45 nM [1].
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- HY-N15128
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- HY-N9145
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Others
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Others
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1beta,10beta-Epoxydehydroleucodin is a Sesquiterpenoids product that can be isolated from the roots of Scorzonera latifolia [1].
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- HY-169330
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Drug Metabolite
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Neurological Disease
Metabolic Disease
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3β,5α,6β-Trihydroxycholanic acid is a metabolite of 3β,5α,6β-Trihydroxycholestane (HY-W010934). 3β,5α,6β-Trihydroxycholanic acid can be used in research related to neurodegenerative diseases associated with lysosomal dysfunction [1].
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- HY-N7768
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- HY-N9738
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Endogenous Metabolite
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Others
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14β,16β-Dihydroxy-3β-(β-D-glucopyranosyloxy)-5α-bufa-20,22-dienolide (compound 10) is a butadiene lactone that can be used in related research in the field of life sciences.
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- HY-N5112B
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Isoarnebin I
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HIF/HIF Prolyl-Hydroxylase
Apoptosis
Notch
NO Synthase
Bcl-2 Family
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Cancer
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β,β-Dimethylacrylshikonin (Isoarnebin I) is a naphthoquinone derivative that can be isolated from Lithospermum erythrorhizon Sieb. et Zucc. β,β-Dimethylacrylshikonin promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway. β,β-Dimethylacrylshikonin inhibits Notch-1 activation. β,β-Dimethylacrylshikonin inhibtis tumor cell proliferation, induces tumor cell apoptosis, and inhibits tumor growth [1] .
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- HY-N9040
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Others
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Others
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6β-Angeloyloxy-1β,10β-epoxy-9-oxo-furaneremophilane is a Sesquiterpenoids product that can be isolated from the herbs of Ligularia songarica. [1].
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- HY-147295
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BTH 1677; Imprime PGG
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Toll-like Receptor (TLR)
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Inflammation/Immunology
Cancer
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Odetiglucan is a novel β-glucan that is a potent immunostimulant and a Dectin-1 (CLEC7A) agonist. Odetiglucan activates innate immune effector cells and triggers a coordinated anti-cancer immune response [1] .
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- HY-P5796
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Calcium Channel
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Neurological Disease
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FS-2 is a potent and specific L-type CaV channel inhibitor. FS-2 inhibits high K + or glucose induced L-type Ca 2+ influx in RIN beta cells [1].
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- HY-W145521
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β Glucan
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Biochemical Assay Reagents
IKK
NO Synthase
Bacterial
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Infection
Inflammation/Immunology
Cancer
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β-1,3-Glucan (β Glucan) is an orally active polysaccharide composed of glucose polymers. β-1,3-Glucan increase the activity of IKKβ kinase, enhances the production of nitric oxide. β-1,3-Glucan improves resistance to Vibrio harveyi infection. β-1,3-Glucan enhances immune response, promotes blood pressure recovery, reduces lung, kidney and liver damage, inhibits the growth of syngeneic tumors [1] .
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- HY-W015084A
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β-Lonone
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Apoptosis
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Cancer
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(E)-β-Ionone is the isomer of β-Ionone (HY-W015084). β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. β-Ionone has anti-cancer activity [1].
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- HY-N15534
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Others
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Others
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5β,6α-Dihydroxy-3β-(β-glucopyranosyloxy)-7-megastigmen-9-one (Compound 2) is a compound found in Agastache rugosa. 5β,6α-Dihydroxy-3β-(β-glucopyranosyloxy)-7-megastigmen-9-one (Compound 2) is promising for research of skin pigment-related diseases [1].
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- HY-101318
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β-FNA hydrochloride
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Opioid Receptor
NO Synthase
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Neurological Disease
Inflammation/Immunology
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β-Funaltrexamine (β-FNA) hydrochloride is a selective μ opioid receptor antagonist. β-Funaltrexamine hydrochloride also inhibits cytokine-induced iNOS activation. β-Funaltrexamine hydrochloride inhibits neuroinflammation and ameliorated neuronal degeneration. β-Funaltrexamine hydrochloride has anti-inflammatory and neuroprotective effects and can be used for research of neurodegenerative diseases (eg: stroke) [1] [2]
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- HY-N15129
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- HY-101461
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Methyl-beta-cyclodextrin
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Biochemical Assay Reagents
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Cancer
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Methyl-β-cyclodextrin (Methyl-beta-cyclodextrin) is a cyclic heptasaccharide used to deliver hydrophobic agents based on its property of solubilizing non-polar substances. Methyl-β-cyclodextrin is also extensively used as a cholesterol-depleting reagent [1]. Methyl-β-cyclodextrin strongly reduces clathrin-dependent endocytosis . Methyl-β-cyclodextrin blocks cell migrasome formation .
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- HY-N7170
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Glycosidase
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Metabolic Disease
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(-)-6β-Hydroxy-5β,8β,9β,10α-cleroda-3,13-dien-16,15-olid-18-oic acid (compound 4) is a α-Glucosidase inhibitor with an IC50 value of 577.7 µM [1].
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- HY-W010934S
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- HY-W113965
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Octaacetyl-β-maltose; β-D-Maltopyranose octaacetate
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Biochemical Assay Reagents
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Others
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β-D-Maltose octaacetate (Octaacetyl-β-maltose; β-D-Maltopyranose octaacetate) is a synthetic sugar compound.
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- HY-141468
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β-CNA dihydrochloride
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Opioid Receptor
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Neurological Disease
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β-Chlornaltrexamine dihydrochloride (β-CNA dihydrochloride) is a potent long-term opioid receptor blocker. β-Chlornaltrexamine dihydrochloride can effectively block the inhibitory effect of κ opioid receptor agonists on dopamine release. β-Chlornaltrexamine dihydrochloride can be used to study the mechanism of pain perception [1].
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- HY-N1615
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Others
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Others
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1beta-Hydroxy-beta-eudesmol is a Sesquiterpenoids product that can be isolated from the herbs of Cymbopogon proximus STAPF. [1].
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- HY-161701
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Androgen Receptor
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Cancer
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(3β,4β,17β)-17-(2-Pyridinylmethyl)androst-5-ene-3,4,17-triol is an androstane derivative with anticancer activity [1].
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- HY-W145556
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Gal beta(1-3)GlcNAc beta(1-3)Gal beta(1-4)Glc-beta-pNP
|
Biochemical Assay Reagents
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Others
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Galβ(1-3)GlcNAcβ(1-3)Galβ(1-4)Glc-β-pNP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-113887
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- HY-N2931
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(+)-β-Rotunol
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Others
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Others
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β-Rotunol ((+)-β-Rotunol) is a natural product, that can be isolated from Cyperus rotundus [1].
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- HY-N10893
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Others
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Others
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(-)-β-Peltatin-5-O-beta-D-glucopyranoside is an active compound. (-)-β-Peltatin-5-O-beta-D-glucopyranoside can be isolated from P. peltatum L [1].
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- HY-N2925
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β-Amyron
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Fungal
COX
PPAR
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Infection
Metabolic Disease
Inflammation/Immunology
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β-Amyrone (β-Amyron) is a triterpene compound which has anti-inflammatory activity through inhibiting the expression of COX-2. β-Amyrone has antifungal activity , as well as antiviral activity against Chikungunya virus. β-Amyrone also inhibits α-glucosidase and acetylcholinesterase (AChE) activity. β-Amyrone can be used in the research of disease like inflammation, infection, and obesity [1] .
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- HY-N0941
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β-Mangostin
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Bacterial
Parasite
Apoptosis
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Infection
Cancer
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beta-Mangostin (β-Mangostin) is a xanthone compound present in Cratoxylum arborescens, with antibacterial and antimalarial activities. beta-Mangostin exhibits antimycobacterial activity against Mycobacterium tuberculosis with an MIC of 6.25 μg/mL. beta-Mangostin possesses in vitro antimalarial activity against Plasmodium falciparum, with an IC50 of 3.00 μg/mL. beta-Mangostin has potent anticancer activity against various cancers (such as hepatocellular carcinoma, leukaemic) [1] .
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- HY-N2920
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11-Oxo-β-amyrin
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Cytochrome P450
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Inflammation/Immunology
Cancer
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β-Amyrenonol (11-Oxo-β-amyrin), an oleanolic-type triterpenoid in licorice roots, is a precursor of Glycyrrhetinic acid. β-Amyrenonol has anti-proliferative and anti-inflammatory activities, and β-Amyrenonol could function as the skeleton for the synthesis of many triterpenoids [1] .
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- HY-16702
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PFT β; Cyclic Pifithrin-α
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MDM-2/p53
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Cancer
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Pifithrin-β (PFT β) is a potent p53 inhibitor with an IC50 of 23 μM.
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- HY-N1601
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2β,6β,15α-(-)-Kaur-16-ene
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Others
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Others
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2β,6β,15α-Trihydroxy-ent-kaur-16-ene (compound 19) is a compound isolated from the aerial parts of Pteris cretica [1].
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-
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- HY-N2277
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-
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- HY-P3908
-
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Amyloid-β
|
Neurological Disease
|
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FITC-β-Ala-Amyloid β-Protein (1-42) ammonium is a FITC tagged Aβ1-42 monomer peptide. Aβ1-42 plays a key role in the pathogenesis of Alzheimer’s disease [1].
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- HY-N13537
-
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Others
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Others
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11β,13-Dihydrotaraxinic acid β-D-glucopyranosyl ester is a natural product that can be isolated from Punica granatum [1].
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- HY-100206
-
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AMPK
|
Neurological Disease
|
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5α-Androstane-3β,5,6β-triol is a neuroprotectant. 5α-Androstane-3β,5,6β-triol can remarkably reverse intracellular acidification and alleviate neuronal injury through the inhibition of AMPK signaling. 5α-Androstane-3β,5,6β-triol remarkably reduced the infarct volume and attenuated neurologic impairment in acute ischemic stroke models of middle cerebral artery occlusion in vivo [1].
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- HY-130553
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β-NAAG; β-N-Acetylaspartylglutamic acid
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Aminopeptidase
mGluR
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Neurological Disease
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β-Spaglumic acid (β-NAAG) is a competitive NAAG peptidase inhibitor (Ki=1 µM) that protects spinal cord neurons from excitotoxicity and hypoxic damage. β-Spaglumic acid is also a selective mGluR3 antagonist (mGluR3 receptor functions to regulate activity-dependent synaptic potentiation in the hippocampus). β-Spaglumic acid can be used in neuroprotection-related studies [1] .
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- HY-N7364
-
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trans-β-Farnesene
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Fungal
CDK
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Infection
Cancer
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(E)-β-Farnesene (trans-β-Farnesene) is an aphid alarm pheromone, which can be found in Phlomis aurea Decne essential oil. (E)-β-Farnesene shows good binding score with a value of -30.64 kcal/mol to the CDK2 receptor. (E)-β-Farnesene also exhibits good affinity to odorant-binding protein 3 (OBP3). (E)-β-Farnesene can be used as a feeding stimulant for the sand fly Lutzomyia longipalpis [1] .
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- HY-N10364
-
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Others
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Cancer
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6β,7β-Epoxyasteriscunolide A, a sesquiterpenoid, shows cytotoxicity against the HL-60 and MOLT-3 leukemia cell lines, with IC50s range 4.1-5.4 μM [1].
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- HY-108059
-
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(3R)-β-Cryptoxanthin
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Endogenous Metabolite
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Neurological Disease
|
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β-Cryptoxanthin ((3R)-β-Cryptoxanthin), isolated from tangerines, red peppers, and pumpkin, is an oxygenated carotenoid and a potent antioxidant. β-Cryptoxanthin has an anti-stress effect [1].
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- HY-N9170
-
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Others
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Cancer
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Lup-20(29)-ene-3β,11β-diol is a natural triterpenoid with anticancer effects. Lup-20(29)-ene-3β,11β-diol exhibits significant cytotoxic activity against HeLa with an IC50 value of 28.5 μM [1].
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- HY-N1222
-
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Others
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Others
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Stigmast-4-ene-3β,6β-diol is a stigmasterol, that can be isolated from Nux Prinsepiae [1].
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- HY-132723S
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- HY-132723AS
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- HY-153256
-
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Prostaglandin Receptor
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Metabolic Disease
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EP3 antagonist 4 (Compound 28) is an EP3 antagonist, with a Ki value of 2 nM for hEP. EP3 antagonist 4 shows low in vivo clearance, high oral AUC, and good bioavailability in the rat full PK studies. EP3 antagonist 4 can be used for research of beta cell dysfunction in diabetes [1].
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- HY-108229
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6β-Hydroxynaltrexone
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Drug Metabolite
Opioid Receptor
|
Neurological Disease
|
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6β-Naltrexol (6β-Hydroxynaltrexone), the primary metabolite of Naltrexone, is a peripherally selective opioid antagonist. 6β-Naltrexol selectively inhibits gastrointestinal opioid effects in human subjects and inhibits Morphine-induced slowing of gastrointestinal transit [1].
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- HY-P5968
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β(25-35)KA
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Amyloid-β
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Neurological Disease
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[Ala28]-β Amyloid(25-35) (β(25-35)KA) is an electrically neutral mutant peptide of Aβ(25-35) that accelerates the aggregation of Firefly Luciferase [1].
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![[Ala28]-β Amyloid(25-35)](//file.medchemexpress.com/product_pic/hy-p5968.gif)
- HY-W414824
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Endogenous Metabolite
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Neurological Disease
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3β,7β-Dihydroxy-5-cholestenoic acid is a C27 acid that displays elevated levels in Niemann-Pick type C and Niemann-Pick type B diseases, contributing to toxicity in oculomotor neurons. It is synthesized from 3β-hydroxy-7-oxocholest-5-en-(25R)26-oic acid (3βH,7O-CA) through the enzymatic action of hydroxysteroid 11-β dehydrogenase 1.
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- HY-P1084
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β-PMTX
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Sodium Channel
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Neurological Disease
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β-Pompilidotoxin (β-PMTX), a wasp venom, can slow sodium channel inactivation and increases steady-state sodium current in cells [1].
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- HY-17031
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Sulfobutylether-β-Cyclodextrin
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Biochemical Assay Reagents
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Others
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SBE-β-CD is a sulfobutylether β-cyclodextrin derivative used as an excipient or a formulating agent to increase the solubility of poorly soluble agents [1].
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- HY-P1051
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Amyloid β-Protein (12-28)
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Amyloid-β
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Neurological Disease
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β-Amyloid (12-28) (Amyloid β-Protein (12-28)) is a peptide fragment of β-amyloid protein (β1-42). β1-42, a 42 amino acid protein , is the major component of senile plaque cores. β-Amyloid (12-28) shows aggregation properties. β-Amyloid (12-28) has the potential for Alzheimer’s disease research [1].
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- HY-N13374
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Others
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Others
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Stigmasta-4,22-diene-3beta,6beta-diol is a natural product [1].
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- HY-N7606
-
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Others
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Others
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(Rac)-β-Chamigrenic acid is a racemate of β-Chamigrenic acid. β-Chamigrenic acid is a sesquiterpenoid isolated from S.chinensis [1]
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- HY-P2998
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-
- HY-N3146
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(3β,4β)-Olean-12-ene-3,23-diol; 3β,24-Dihydroxyolean-12-ene
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Others
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Others
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Olean-12-ene-3β,24-diol ((3β,4β)-Olean-12-ene-3,23-diol) is a product that can be isolated from [1].
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- HY-137781
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- HY-W145631
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GalNAc beta(1-4)GlcNAc-beta-pNP
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Biochemical Assay Reagents
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Others
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GalNAcβ(1-4)GlcNAc-β-pNP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W145558
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Gal beta(1-4)Glc-beta-MP
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Biochemical Assay Reagents
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Others
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Galβ(1-4)Glc-β-MP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W145607
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Gal beta(1-3)GalNAc-beta-pNP
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Biochemical Assay Reagents
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Others
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Galβ(1-3)GalNAc-β-pNP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W699164
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Benzyl β-D-galactopyranosyl-(1→4)-β-D-N-acetylglucosamine
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Biochemical Assay Reagents
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Others
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Gal1-β-4GlcNAc-β-Bn (Benzyl β-D-galactopyranosyl-(1→4)-β-D-N-acetylglucosamine) is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology [1].
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- HY-P9967
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BIIB037
|
Amyloid-β
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Neurological Disease
|
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Aducanumab (BIIB037) is a human monoclonal antibody that selectively targets aggregated amyloid-beta (Aβ). Aducanumab shows brain penetration, and can be used for Alzheimer's disease (AD) research [1].
|
-
- HY-152073
-
|
|
Fluorescent Dye
|
Others
|
|
BETA-1 is the first twisted intramolecular charge transfer (TICT)-aggregation-induced emission (AIE) integration molecule. BETA-1 emits cyan fluorescence in lipid droplets (LDs) and red fluorescence in mitochondria. BETA-1 can be used for the simultaneous and dual-color imaging of LDs and mitochondria in vivo and in vitro [1].
|
-
- HY-B1837A
-
|
beta-Cyfluthrin
|
Calcium Channel
SOD
|
Neurological Disease
|
|
β-Cyfluthrin (beta-Cyfluthrin) is a type II synthetic pyrethroid and also an active ingredient of many insecticide products used for pestsin agriculture. β-Cyfluthrin is a neurotoxicant and affects calcium concentration in nervous tissue by inhibiting Ca 2+ ATPase involved in calcium transport [1].
|
-
- HY-B1837AR
-
|
beta-Cyfluthrin (Standard)
|
Calcium Channel
SOD
|
Neurological Disease
|
|
β-Cyfluthrin (Standard) is the analytical standard of β-Cyfluthrin. This product is intended for research and analytical applications. β-Cyfluthrin (beta-Cyfluthrin) is a type II synthetic pyrethroid and also an active ingredient of many insecticide products used for pestsin agriculture. β-Cyfluthrin is a neurotoxicant and affects calcium concentration in nervous tissue by inhibiting Ca 2+ ATPase involved in calcium transport [1].
|
-
- HY-101103
-
|
(2-Hydroxypropyl)-β-cyclodextrin
|
Biochemical Assay Reagents
|
Cancer
|
|
HP-β-CD ((2-Hydroxypropyl)-β-cyclodextrin) is a widely used drug delivery vehicle to improve the stability and bioavailability.
|
-
- HY-165277
-
|
|
Angiotensin-converting Enzyme (ACE)
|
Cardiovascular Disease
|
|
ε-Biotinamidocaproyl-β-alanyl-β-alanyl-lisinopril is an angiotensin-converting enzyme (ACE) inhibitor. Structurally, ε-Biotinamidocaproyl-β-alanyl-β-alanyl-lisinopril is a biotinylated derivative of lisinopril (HY-18206), with a chemical structure linking the biotin molecule and the lisinopril molecule composed of 19 atoms. ε-Biotinamidocaproyl-β-alanyl-β-alanyl-lisinopril can bind to both ACE and streptavidin (HY-P3152) simultaneously, making it possible to separate and purify ACE using streptavidin-agarose beads [1].
|
-
- HY-B0141C
-
|
β-Estradiol hemihydrate; 17β-Estradiol hemihydrate; 17β-Oestradiol hemihydrate
|
Estrogen Receptor/ERR
Endogenous Metabolite
Bacterial
|
Neurological Disease
Cancer
|
|
Estradiol (β-Estradiol) hemihydrate is a steroid hormone and the major female sex hormone. Estradiol (β-Estradiol) hemihydrate can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol (β-Estradiol) hemihydrate can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering [1] .
|
-
- HY-107043
-
-
- HY-P10605
-
|
|
Akt
GSK-3
|
Cancer
|
|
GSK3β-peptide is a substrate mimetic peptide of glycogen synthase kinase 3-β (GSK3-β) that can bind to the active site of GSK3-β and mimic the behavior of a real substrate. GSK3β-peptide can be used to develop substrate mimetic inhibitors of Akt as potential anticancer drugs [1].
|
-
- HY-P0128F1
-
|
|
Amyloid-β
|
Neurological Disease
|
|
FITC-β-Ala-β-Amyloid (25-35) is a fluorescent product labeled by FITC that can be used in Alzheimer's disease research [1].
|
-
- HY-N1202
-
|
Sitostane-3β,5α,6β-triol
|
Others
|
Others
|
|
Sitostanetriol (Sitostane-3β,5α,6β-triol) is a steroid isolated from Casearia membranacea (Flacourtiaceae) [1].
|
-
- HY-114319
-
|
|
Others
|
Cancer
|
|
β-Cembrenediol is a potent and orally active anticancer agent. β-Cembrenediol shows phytotoxic activities. β-Cembrenediol reduces the migration and colony formation. β-Cembrenediol decreases the protein expression of TDO2, IDO1. β-Cembrenediol has the potential for the research of prostate cancer [1] .
|
-
- HY-P4211
-
|
|
Bacterial
|
Infection
|
|
PSM-β is a active peptide , which can be isolated from Staphylococcus epidermidis. PSM-β is an analog of staphylococcal toxins, as well as a termed phenol-soluble modulin. PSM-β has bacteriostatic and poorly hemolytic properties [1] .
|
-
- HY-N2922
-
|
|
Amyloid-β
NF-κB
|
Neurological Disease
Inflammation/Immunology
|
|
β-Amyrin shows effectively counteract amyloid β (Aβ)-induced impairment of long-term potentiation (LTP). β-Amyrin is a promising candidate for Alzheimer's disease (AD) research. β-Amyrin exhibits anti-inflammatory effects, protective activity against pulmonary fibrosis, and notable antibacterial capabilities. β-Amyrin is an orally active natural triterpenoid compound [1] .
|
-
- HY-N6018
-
|
|
Caspase
TNF Receptor
SOD
Reactive Oxygen Species
|
Inflammation/Immunology
Cancer
|
|
Beta-Eudesmol has anticancer and anti-inflammatory activities. Beta-Eudesmol can induce apoptosis. Beta-Eudesmol is a neostigmine antagonist. Beta-Eudesmol can antagonize neostigmine-induced neuromuscular failure. Beta-Eudesmol can be used in the study of sepsis diseases. Beta-Eudesmol is a sesquiterpene-like compound that can be extracted from the rhizome of Atractylodes lancea [1] .
|
-
- HY-N2337
-
|
11β-Hydroxyprogesterone
|
11β-HSD
|
Cardiovascular Disease
|
|
11beta-Hydroxyprogesterone is a potent inhibitors of 11β-Hydroxysteroid dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED50 of 10 nM.
|
-
- HY-116284A
-
|
Methyl β-D-glucoside hemihydrate
|
Others
|
Others
|
|
Methyl β-D-glucopyranoside (Methyl β-D-glucoside) hemihydrate is a hemihydrate compound. Methyl β-D-glucopyranoside hemihydrate less reactive at higher PH. The formation of Methyl β-D-glucopyranoside hemihydrate is stereospecific [1] .
|
-
- HY-142279S
-
-
- HY-113068
-
|
|
Tyrosinase
|
Metabolic Disease
|
|
(rel)-β-Tocopherol is a relative configuration of β-Tocopherol.(±)-β-Tocopherol is a lipid-soluble form of vitamin E with antioxidant activity. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol [1].
|
-
- HY-113482
-
|
1β-OH-DCA
|
Endogenous Metabolite
Cytochrome P450
|
Metabolic Disease
|
|
1β-Hydroxydeoxycholic acid (1β-OH-DCA), a secondary bile acid, is a CYP3A biomarker. Deoxycholic acid is specifically metabolized into 1β-Hydroxydeoxycholic acid by CYP3A4 and CYP3A7 using recombinant human CYP450 enzymes [1].
|
-
- HY-107324R
-
|
|
Apoptosis
|
Cancer
|
|
β-Elemene (Standard) is the analytical standard of β-Elemene. This product is intended for research and analytical applications. β-Elemene ((-)-β-Elemene; Levo-β-elemene) is isolated from natural plant Curcuma aromatica with an antitumor activity. β-Elemene can induce cell apoptosis.
|
-
- HY-N13258
-
|
β-Citrylglutamic acid
|
Others
|
Others
|
|
β-Citryl-L-glutamic acid (β-Citrylglutamic acid) is a citrylglutamic acid, that can be isolated from newborn rat brain [1].
|
-
- HY-113630A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
20β-22-Azacholesterol is the β-configuration of 22-Azacholesterol (HY-113630). 20β-22-Azacholesterol is an inhibitor for cholesterol side chain cleavage reactions [1].
|
-
- HY-125396
-
|
11-Deoxy-PGF2β
|
Endogenous Metabolite
|
Others
|
|
11-Deoxyprostaglandin F2β (11-deoxy PGF2β) is an analog of PGF2β (HY-12956B). PGF2β is a metabolite produced by cyclooxygenase metabolism of arachidonic acid. PGF2β induces dose-dependent release of hexose containing mucin [1] .
|
-
- HY-130046S1
-
-
- HY-N1035
-
|
|
Others
|
Others
|
|
Urs-12-ene-3β,16β,22α-triol is a terpenoid compound isolated from the ethanol extract of fresh aerial parts of the Patagonian shrub Nardophyllum bryoides [1].
|
-
- HY-P0128
-
|
Amyloid beta-peptide (25-35); Aβ25-35; β-Amyloid peptide (25-35)
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (25-35) (Amyloid beta-peptide (25-35)) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide, has shown neurotoxic activities in cultured cells [1].
|
-
- HY-114850
-
-
- HY-P1051A
-
|
Amyloid β-Protein (12-28) (TFA); Amyloid beta-Peptide (12-28) (human) TFA; β-Amyloid protein fragment(12-28) TFA
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (12-28) (TFA) (Amyloid β-Protein (12-28) (TFA)) is a peptide fragment of β-amyloid protein (β1-42). β1-42, a 42 amino acid protein , is the major component of senile plaque cores. β-Amyloid (12-28) (TFA) shows aggregation properties. β-Amyloid (12-28) (TFA) has the potential for Alzheimer’s disease research [1].
|
-
- HY-W416287
-
-
- HY-N8573
-
|
|
Bacterial
|
Infection
|
|
β-phellandrene is an orally active monocyclic monoterpenes. β-Phellandrene is obtained from Carum petroselinum. β-phellandrene has strong ability to kill pest. β-phellandrene can be used as oil additives, natural pesticides and synthetic materials [1] .
|
-
- HY-133707
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
β-Muricholic acid is a potent and orally active biliary cholesterol-desaturating agent. β-Muricholic acid prevents cholesterol gallstones. β-Muricholic acid inhibits lipid accumulation. β-Muricholic acid has the potential for the research of nonalcoholic fatty liver disease (NAFLD) [1] .
|
-
- HY-W243244
-
-
- HY-160416
-
-
- HY-W357155
-
|
Galactosyl-N-acetylglucosaminyl-β-p-nitrophenyl
|
Biochemical Assay Reagents
|
Others
|
|
Gal1-β-3GlcNAc-β-PNP (Galactosyl-N-acetylglucosaminyl-β-p-nitrophenyl) is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology [1].
|
-
- HY-W015084AR
-
|
|
Apoptosis
|
Cancer
|
|
(E)-β-Ionone (Standard) is the analytical standard of (E)-β-Ionone. This product is intended for research and analytical applications. (E)-β-Ionone is the isomer of β-Ionone (HY-W015084). β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. β-Ionone has anti-cancer activity [1].
|
-
- HY-B0445A
-
|
β-DPN sodium; β-NAD sodium; β-Nicotinamide Adenine Dinucleotide sodium
|
Endogenous Metabolite
|
Metabolic Disease
|
|
NAD (β-Nicotinamide Adenine Dinucleotide) sodium is an analogue of NAD. NAD sodium can be reduced to β-nicotinamide adenine dinucleotide (NADH) during coupling with reactions which oxidize organic substrates. NAD sodium can be converted to β-nicotinamide adenine dinucleotide (NADH) and passes to the inside of mitochondria that indirectly generates ATP [1].
|
-
- HY-N5112A
-
|
Arnebin 1
|
HIF/HIF Prolyl-Hydroxylase
|
Others
|
|
β,β-Dimethylacrylalkannin (Arnebin 1) is a napthoquinone isolated from Alkanna cappadocica , increases collagen and involucrin content in skin cells [1].
|
-
- HY-W145663
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Gal-β1,3-GalNAc-β-OMe is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-113068R
-
|
|
Tyrosinase
|
Metabolic Disease
|
|
(rel)-β-Tocopherol (Standard) is the analytical standard of (rel)-β-Tocopherol. This product is intended for research and analytical applications. (rel)-β-Tocopherol is a relative configuration of β-Tocopherol.(±)-β-Tocopherol is a lipid-soluble form of vitamin E with antioxidant activity. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol [1].
|
-
- HY-N10497
-
|
|
nAChR
|
Neurological Disease
|
|
Dihydro-β-erythroidine is a a competitive nicotinic receptor antagonist. Dihydro-β-erythroidine blocks the discriminative stimulus properties of nicotine. Dihydro-β-erythroidine inhibits the anxiolytic effect of nicotine induced [1] .
|
-
- HY-F0004
-
|
β-NM; NMN
|
Endogenous Metabolite
|
Neurological Disease
Cancer
|
|
β-nicotinamide mononucleotide (β-NM) is a product of the nicotinamide phosphoribosyltransferase (NAMPT) reaction and a key NAD + intermediate. The pharmacological activities of β-nicotinamide mononucleotide include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity [1].
|
-
- HY-P10617
-
|
|
Endogenous Metabolite
|
Cardiovascular Disease
|
|
Salusin-β is an endogenous bioactive peptide with significant hemodynamic and mitogenic activity. Salusin-β can stimulate the proliferation of quiescent vascular smooth muscle cells (VSMCs) and fibroblasts, leading to a rapid and significant decrease in blood pressure and heart rate. In addition, Salusin-β can stimulate the release of arginine vasopressin from the pituitary gland in rats. This makes Salusin-β have important application potential in cardiovascular disease research [1].
|
-
- HY-W019878
-
|
β-Lipotropin 61-91
|
Opioid Receptor
|
Cardiovascular Disease
Neurological Disease
|
|
β-Endorphin, rat (β-Lipotropin 61-91), a neuropeptide, is involved in cardiovascular regulation. β-Endorphin, rat induces marked, prolonged muscular rigidity and immobility similar to a catatonic state in rats [1] .
|
-
- HY-P4865
-
-
- HY-P4870
-
-
- HY-P4868
-
-
- HY-P1522
-
-
- HY-125586
-
|
|
DNA/RNA Synthesis
ADC Cytotoxin
|
Cancer
|
|
β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom. β-Amanitin inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis. β-Amanitin can be used as a cytotoxic component of antibody-drug conjugates (ADCs) [1] .
|
-
- HY-N6575
-
-
- HY-130570
-
|
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
Beta-gal-nonoate is a β-galactosidase dependent nitric oxide (NO) donor that releases NO once activated by β-galactosidase. β-Gal-NONOate has bactericidal activity and can be used as a bactericide [1].
|
-
- HY-N9987
-
-
- HY-160777
-
|
Galeterone 3β-imidazole
|
Molecular Glues
Androgen Receptor
MNK
|
Cancer
|
|
VNPP433-3β is a molecular glue degrader, which degrades androgen receptor (AR) and its splice variants (AR-Vs) and MAP kinase-interacting serine/threonine protein kinase Mnk1/2. VNPP433-3β inhibits proliferation of cancer cell LNCaP, C4-2B and CWR22Rv1 with GI50 of 0.2, 0.3 and 0.31 μM. VNPP433-3β exhibits good pharmacokinetic characters in CD-1 mouse and inhibits tumor growth in the CWR22Rv1 xenograft mouse model [1].
|
-
- HY-N2921
-
|
(3β)-3-(Acetyloxy)olean-12-en-11-one; 11-Oxo-β-amyrin acetate
|
Others
|
Others
|
|
β-Amyrenonol acetate ((3β)-3-(Acetyloxy)olean-12-en-11-one) is a Triterpenoids product that can be isolated from the barks of Clausena excavata [1].
|
-
- HY-W357146
-
|
Phenethyl β-D-galactoside
|
Others
|
Others
|
|
2-Phenylethyl β-D-galactopyranoside (Phenethyl β-D-galactoside) can be synthesized catalyzed by Aspergillus oryzae β-galactosidase [1].
|
-
- HY-126083
-
|
Wortmannin-17β-ol
|
PI3K
|
Others
Cancer
|
|
17β-Hydroxywortmannin (Wortmannin-17β-ol) is an orally active inhibitor for phosphatidylinositol-3-kinase (PI-3-kinase) with an IC50 of 0.5 nM, suppresses the osteoclast resorption with an IC50 of 10 nM [1]. 17β-Hydroxywortmannin exhibits antitumor activity .
|
-
- HY-133708
-
|
1-O-Galloyl-β-D-glucose
|
Aldose Reductase
Reactive Oxygen Species
NF-κB
PDGFR
SOD
|
Neurological Disease
Metabolic Disease
|
|
β-Glucogallin is an orally active and selective aldose reductase (AKR1B1) inhibitor with an IC50 value of 58 μM when using Glyceraldehyde (HY-128748) as AKR1B1 substrate. β-Glucogallin reduces ROS, PDGF, RAGE, and NF-κB. β-Glucogallin increases SOD. β-Glucogallin has antioxidant and hepatoprotective effects. β-Glucogallin can be used in retinal research [1] .
|
-
- HY-P4886
-
|
|
Amyloid-β
|
Neurological Disease
|
|
Amyloid β-Protein (3-42) is the precursor of Pyr peptide. Pyroglutamate-modified Aβ (pEAβ) (3-42) is the core of the amyloid template block in Alzheimer's disease. pEAβ(3-42) accelerated the aggregation of Aβ(1-42), while Aβ(1-42) significantly slowed the primary and secondary nucleation of pEAβ(3-42) [1].
|
-
- HY-131171
-
|
3β,5α-NET
|
Drug Derivative
|
Others
|
|
3β,5α-Tetrahydronorethisterone is a tetrahydro derivative of norethindrone (NET) [1].
|
-
- HY-16702A
-
|
PFT β hydrobromide; Cyclic Pifithrin-α hydrobromide
|
MDM-2/p53
Ferroptosis
|
Cancer
|
|
Pifithrin-β hydrobromide (PFT β hydrobromide) is a potent p53 inhibitor with an IC50 of 23 μM.
|
-
- HY-P1084A
-
|
β-PMTX TFA
|
Sodium Channel
|
Neurological Disease
|
|
β-Pompilidotoxin TFA (β-PMTX TFA), a wasp venom, can slow sodium channel inactivation and increases steady-state sodium current in cells [1].
|
-
- HY-P1046
-
|
Amyloid β-Protein (1-15)
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (1-15) is a fragment of β-Amyloid peptide. Beta-amyloid is a peptide that forms amyloid plaques in the brains of Alzheimer's disease (AD) patients.
|
-
- HY-B1204S
-
-
- HY-N0411
-
|
Provitamin A; beta-Carotene
|
Endogenous Metabolite
Apoptosis
Reactive Oxygen Species
|
Metabolic Disease
Cancer
|
|
β-Carotene (Provitamin A), a carotenoid compound, is a naturally-occurring vitamin A precursor. β-Carotene is a modulator of reactive oxygen species (ROS), with antioxidant and antiinflammatory activities. β-Carotene may serve as an antioxidant or as a prooxidant, depending on its intrinsic properties as well as on the redox potential of the biological environment in which it acts. β-Carotene induces breast cancer cells apoptosis, with anticancer activities [1] .
|
-
- HY-P0179
-
-
- HY-136736
-
|
|
Beta-secretase
|
Neurological Disease
|
|
β-Secretase Inhibitor II is a β-Secretase inhibitor. β-Secretase Inhibitor II is a simple tripeptide aldehyde (IC50=700 nM for inhibition of total Aβ and IC50=2.5 μM for Aβ1–42). β-Secretase Inhibitor II can be used for the research of Alzheimer's disease [1].
|
-
- HY-N2922R
-
|
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyrin shows effectively counteract amyloid β (Aβ)-induced impairment of long-term potentiation (LTP). β-Amyrin is a promising candidate for Alzheimer's disease (AD) research. β-Amyrin exhibits anti-inflammatory effects, protective activity against pulmonary fibrosis, and notable antibacterial capabilities. β-Amyrin is an orally active natural triterpenoid compound [1] .
|
-
- HY-N2274
-
|
12-Oleanene-3β,16β,23,28-tetrol; 3β,16β-12-Oleanene-3, 16,23,28-tetrol
|
Others
|
Cancer
|
|
23-Hydroxylongispinogenin (12-Oleanene-3β,16β,23,28-tetrol) is extracted from Lysimachia heterogenea Klatt. Lysimachia heterogenea Klatt is a perennial herb, which is used as a folk medicine in subduing swelling and detoxicating in China. The effective fraction LH-1 of L. heterogene has antitumor activity [1].
|
-
- HY-130223
-
|
11β-Dinoprostone; 11β-PGE2
|
Prostaglandin Receptor
|
Endocrinology
|
|
11β-Prostaglandin E2 (11β-Dinoprostone), a Prostanoid derivative, inhibits [ 3H]PGE2 binding to hypothalamic membranes in the rat with a Ki of 53.3 nM [1].
|
-
- HY-N13365
-
|
|
Others
|
Others
|
|
1,10β-Epoxy-6β-isobutanoyloxy-9-oxofuranoeremophilane is a natural product [1].
|
-
- HY-141672
-
|
17β-Estradiol 3-sulfate sodium
|
GABA Receptor
|
Neurological Disease
|
|
17β-Estradiol sulfate (sodium), also known as β-Estradiol 3-sulfate sodium salt, is a neuroactive steroid [1] .
|
-
- HY-162832
-
|
|
Amyloid-β
|
Neurological Disease
|
|
Amyloid-β-IN-1 (compound 13) is a synthetic peptide containing the hydrophobic C-terminal region "VVIA-NH2" and its reverse sequence "AIVV-NH2" of Aβ42, which is an Aβ inhibitor. Amyloid-β-IN-1 can inhibit Aβ aggregation and has neuroprotective effects [1].
|
-
- HY-P10628
-
|
|
Amyloid-β
|
Neurological Disease
|
|
β Amyloid (1-14), human is a peptide fragment of β-amyloid protein (Aβ), which is obtained by hydrolysis of Aβ1-40 peptide by catalytic antibody light chain #7TR. β Amyloid (1-14), human can be used for Alzheimer's disease research [1].
|
-
- HY-N6652
-
|
Uracil 1-β-D-arabinofuranoside
|
Others
|
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
|
1-beta-D-Arabinofuranosyluracil (Uracil 1-β-D-arabinofuranoside) isolated from the Caribbean sponge Tectitethya crypta, is a methoxyadenosine derivative. 1-beta-D-Arabinofuranosyluracil has demonstrated a diverse bioactivity profile including anti-inflammatory activity, analgesic and vasodilation properties [1]. 1-beta-D-Arabinofuranosyluracil reduces a proliferation of mouse lymphoma cells .
|
-
- HY-P1521
-
|
beta-Amyloid (15-21)
|
Amyloid-β
|
Neurological Disease
|
|
β-amyloid (15-21) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.
|
-
- HY-117266
-
|
beta-D-Galactopyranoside, 98%
|
Biochemical Assay Reagents
|
Others
|
|
β-D-Galactopyranoside, 98% (beta-D-Galactopyranoside, 98%) can be used in glycobiology research.
|
-
- HY-N8090
-
|
|
NO Synthase
|
Inflammation/Immunology
|
|
(3β,7β,12β,20Z)-3,7,12-Trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid, a lanostane triterpenoids, exhibits obvious NO inhibitory activity on n LPS-induced BV-2 microglia cells with an IC50 of 9.55 uM. (3β,7β,12β,20Z)-3,7,12-Trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid has anti-inflammatory activities [1].
|
-
- HY-114464
-
|
4-Androsten-11β-ol-3,17-dione
|
Endogenous Metabolite
11β-HSD
|
Endocrinology
|
|
11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor. As 4-androstenedione increases, measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism [1] .
|
-
- HY-N11706
-
|
(+)-β-Cedrene
|
Fungal
|
Infection
Inflammation/Immunology
|
|
β-Cedrene ((+)-β-Cedrene) is a sesquiterpene compound that can be isolated from Centaurea kotschyi var. kotschyi and Centaurea kotschyi var. decumbens, exhibiting antibacterial, anti-inflammatory, antispasmodic, tonic, diuretic, sedative, insecticidal, and antifungal activities. β-Cedrene is also a potent competitive inhibitor of the CYP2B6-mediatedbupropion hydroxylase, with a Ki value of 1.6 μM [1] .
|
-
- HY-N0171R
-
|
β-Sitosterol (Standard); 22,23-Dihydrostigmasterol (Standard))
|
Apoptosis
Endogenous Metabolite
|
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
|
Beta-Sitosterol (Standard) is the analytical standard of Beta-Sitosterol. This product is intended for research and analytical applications. Beta-Sitosterol (Standard) includes β-sitosterol (≥80%), stigmasterol, campesterol and brassicasterol mainly. Beta-Sitosterol is a plant sterol. Beta-Sitosterol (Standard) interfere with multiple cell signaling pathways, including cell cycle, apoptosis, proliferation, survival, invasion, angiogenesis, metastasis and inflammation [1].
|
-
- HY-N5081
-
|
|
Others
|
Cancer
|
|
1αH,5αH-Guaia-6-ene-4β,10β-diol is a sesquiterpenoid derivative identified from Alisma orientale. 1αH,5αH-Guaia-6-ene-4β,10β-diol has anti-cancer activities [1].
|
-
- HY-113351
-
-
- HY-N3604
-
|
2β,9α-Clovanediol; 2β,9α-Dihydroxyclovane; Clovane-2β,9α-diol
|
Others
|
Others
|
|
Clovanediol (2β,9α-Clovanediol) is a product that can be isolated from [1].
|
-
- HY-117215
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Beta-Ocimene is a naturally occurring organic compound that belongs to the terpene family. It exists as a mixture of three isomers: cis β-Ocimene, trans β-Ocimene and myrcene-like β-Ocimene. It has a pleasant, sweet herbaceous scent and is found in many plants, including mint, basil, parsley, and kumquat. β-Ocimene is widely used in the flavor and fragrance industry due to its characteristic aroma and taste. It also has potential applications in agriculture as natural insect repellants and pheromones that attract beneficial insects. β-Ocimene has potential anti-inflammatory and anticancer activities.
|
-
- HY-137824
-
|
4-Methylumbelliferyl-β-D-xyloside
|
Biochemical Assay Reagents
|
Others
|
|
4-Methylumbelliferyl-β-D-xylopyranoside (MuX) can be used as substrate for the research of β-Xylosidase activity. 4-Methylumbelliferyl-β-D-xylopyranoside shows burst, steady-state kinetics, which supports the conclusion that hydrolysis of the glycosidic bonds for the substrate 4-Methylumbelliferyl-β-D-xylopyranoside is rapid [1] .
|
-
- HY-P2869A
-
|
|
Glycosidase
|
Metabolic Disease
|
|
β1-3 Galactosidase is a highly specific exoglycosidase that catalyzes the hydrolysis of terminal β1-3-linked galactose from oligosaccharides and glycoprotein substrates, at a much lower rate, β1-6 linked galactose residues from oligosaccharides [1].
|
-
- HY-W010934
-
|
|
Biochemical Assay Reagents
|
Others
|
|
3β,5α,6β-Trihydroxycholestane is a steroid that occurs naturally in the body and is also found in certain foods. It belongs to a class of compounds known as cholestanes, which are closely related to the better known cholesterol. This particular compound is formed from cholesterol through a series of enzymatic reactions in the liver and other organs. It has been studied for its potential health benefits, including its ability to reduce inflammation and oxidative stress in the body. Some research suggests that it may also play a role in regulating blood sugar levels and improving insulin sensitivity. Despite these potential benefits, 3β,5α,6β-Trihydroxycholestane is not widely used as a supplement or medicine due to its relatively low content, focus on natural resources and limited research. However, researchers continue to investigate its potential uses and effects on human health.
|
-
- HY-108693R
-
|
|
Leukotriene Receptor
|
Inflammation/Immunology
|
|
β-Tocotrienol (Standard) is the analytical standard of β-Tocotrienol. This product is intended for research and analytical applications. β-Tocotrienol is one form of vitamin E. β-Tocotrienol is a less potent antioxidant than α-tocotrienol [1].
|
-
- HY-147007
-
|
|
β-catenin
Wnt
CDK
|
Cancer
|
|
β-catenin-IN-3 (Compound C2) is a selective β-catenin inhibitor. β-catenin-IN-3 binds to allosteric site on the surface of β-catenin with K D calculated at 54.96 nM. β-catenin-IN-3 selectively inhibits β-catenin via targeting a cryptic allosteric modulation site, lowers its cellular load. β-catenin-IN-3 significantly reduces viability of β-catenin driven cancer cells, and triggers β-catenin degradation via proteasome system in β-catenin-overexpressing cancer cells [1].
|
-
- HY-146767S
-
-
- HY-149845
-
|
|
GSK-3
PROTACs
|
Neurological Disease
|
|
PROTAC GSK-3β Degrader-1 (compound 1) is a degrader targets GSK-3β degradation with an IC50 value of 833 nM. PROTAC GSK-3β Degrader-1 contains SB-216763 (a GSK-3β inhibitor), a PEG linker and a CRBN (E3 ligase liand). PROTAC GSK-3β Degrader-1 reduces the neurotoxicity induced by Aβ25-35 peptide and CuSO4. PROTAC GSK-3β Degrader-1 can be used to research in Alzheimer's disease [1].
|
-
- HY-W154295
-
|
|
Fluorescent Dye
|
Others
|
|
Purple-β-D-Gal is a chromogenic β-galactosidase substrate. Intracellular enzymatic hydrolysis of Purple-β-D-Gal generates free indoxyl molecules, which undergo in situ oxidation and subsequent dimerization to produce chromogenic, water-insoluble, indigo precipitates. Purple-β-D-Gal can be used for the detection of β-galactosidase activity [1].
|
-
- HY-N7364R
-
|
|
Fungal
|
Infection
Cancer
|
|
(E)-β-Farnesene (Standard) is the analytical standard of (E)-β-Farnesene. This product is intended for research and analytical applications. (E)-β-Farnesene (trans-β-Farnesene) is a volatile sesquiterpene hydrocarbon which can be found in Phlomis aurea Decne essential oil. (E)-β-Farnesene can be used as a feeding stimulant for the sand fly Lutzomyia longipalpis [1] .
|
-
- HY-P1481A
-
-
- HY-E70136
-
|
|
Others
|
Metabolic Disease
|
|
Endo-β-Galactosidase catalyzes the hydrolysis of internal β1-4 galactose linkages in unbranched, repeating poly-N-acetyllactosamine ([GlcNAc- (1-3)Gal- (1-4)]n) structures [1].
|
-
- HY-128174
-
|
beta-CCM; Ro 22-7497
|
GABA Receptor
|
Neurological Disease
|
|
β-CCM is a benzodiazepine receptor inverse agonist with anxiogenic and proconvulsant effects. β-CCM enhances emotional reactivity and reduces vulnerability to interference in spatial working memory tasks. β-CCM can be used for research on anxiety-related disorders [1] .
|
-
- HY-P2769A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Thermostable β-Agarase is a hydrolase that can hydrolyze the β-1,4 linkages in agarose to produce neoagaro-oligosaccharides, and it can be used to extract DNA and RNA from gels. Compared to conventional β-Agarase, Thermostable β-Agarase exhibits higher heat resistance and stronger hydrolytic activity. The thermostable properties of Thermostable β-Agarase simplify experimental procedures and make it suitable for the rapid purification of intact large DNA molecules [1].
|
-
- HY-108229S
-
|
6β-Hydroxynaltrexone-d3
|
Isotope-Labeled Compounds
Opioid Receptor
Drug Metabolite
|
Neurological Disease
|
|
6β-Naltrexol-d3 (6β-Hydroxynaltrexone-d3) is deuterium labeled 6β-Naltrexol. 6β-Naltrexol (6β-Hydroxynaltrexone), the primary metabolite of Naltrexone, is a peripherally selective opioid antagonist. 6β-Naltrexol selectively inhibits gastrointestinal opioid effects in human subjects and inhibits Morphine-induced slowing of gastrointestinal transit [1] .
|
-
- HY-W416255
-
-
- HY-P1474
-
|
Amyloid β-Protein (22-35)
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid 22-35 (Amyloid β-Protein 22-35), the residues 22-35 fragment ofβ-amyloid protein, has a cytotoxic effect on cultured neurons from the rat hippocampus in serum-free medium. β-Amyloid 22-35 forms aggregates and typical amyloid fibrils resembling those of the β-amyloid protein in neutral buffer solution) [1].
|
-
- HY-N1968
-
|
Quercetin-3-O-beta-D-glucose-7-O-beta-D-gentiobioside
|
Others
|
Others
|
|
Quercetin-3-O-β-D-glucose-7-O-β-D-gentiobiosiden is a flavonoid from Quercetin.
|
-
- HY-116051A
-
|
16,16-Dimethyl-PGF2β
|
Prostaglandin Receptor
|
Cardiovascular Disease
|
|
16,16-Dimethylprostaglandin F2β (16,16-Dimethyl-PGF2β) is an analog of PGF2β (HY-12956B), which is an irratant, but prevents the aspecifically induced bronchospasm [1].
|
-
- HY-W205320
-
-
- HY-P1468
-
|
Amyloid β-Protein (1-28)
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (1-28) is a β-Amyloid protein fragment involved in metal binding. Beta-amyloid is a peptide that forms amyloid plaques in the brains of Alzheimer's disease (AD) patients.
|
-
- HY-P1466
-
|
Amyloid β-Protein (1-16)
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (1-16) is a β-Amyloid protein fragment involved in metal binding. Beta-amyloid is a peptide that forms amyloid plaques in the brains of Alzheimer's disease (AD) patients.
|
-
- HY-169632
-
|
|
GSK-3
|
Neurological Disease
|
|
GSK3β-IN-1 (compound 1) is a glycogen synthase kinase-3β (GSK-3β) inhibitor (IC50=65 nM), which can be used in the study of Alzheimer's disease [1].
|
-
- HY-128976
-
|
DHED
|
Estrogen Receptor/ERR
|
Metabolic Disease
|
|
10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) is a brain-targeting bioprecursor proagent of the main human estrogen, 17β-estradiol, alleviates hot flushes in rat models of thermoregulatory dysfunction of the brain [1].
|
-
- HY-113478R
-
|
|
Drug Metabolite
|
Metabolic Disease
|
|
3β-Ursodeoxycholic acid (Standard) is the analytical standard of 3β-Ursodeoxycholic acid. This product is intended for research and analytical applications. 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) is a bile acid. 3β-Ursodeoxycholic acid shows good tolerance and well intestinal absorption by oral adminstation. 3β-Ursodeoxycholic acid can be isomerized by intestinal and hepatic enzymes to yield UDCA [1].
|
-
- HY-E70110
-
|
|
Others
|
Others
|
|
Endo-1,4-β-mannanase is an important catalytic agent that randomly cleave the β-1,4-linkage in the mannan backbone and release short β-1,4-mannooligosaccharides and mannose [1].
|
-
- HY-149542
-
|
|
Tau Protein
Apoptosis
GSK-3
|
Neurological Disease
|
|
GSK-3β inhibitor 15 (Compound 54) is a GSK-3β inhibitor (IC50: 3.4 nM). GSK-3β inhibitor 15 inhibits Aβ1-42-induced GSK-3β and tau protein phosphorylation. GSK-3β inhibitor 15 inhibits LPS-induced iNOS expression. GSK-3β inhibitor 15 has neuroprotective effects on Aβ1-42-induced neurotoxicity. GSK-3β inhibitor 15 can be used for research of Alzheimer’s disease (AD) [1].
|
-
- HY-W706304
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Gal1-β-4GlcNAc1-β-6Gal is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology [1].
|
-
- HY-125849
-
|
Chrysin 7-O-β-gentiobioside
|
Drug Derivative
|
Cancer
|
|
Chrysin 7-O-beta-gentiobioside (Chrysin 7-O-β-gentiobioside) is the glycosylation product of Chrysin [1].
|
-
- HY-113341
-
-
- HY-N11600
-
|
|
Apoptosis
|
Cancer
|
|
β-Apopicropodophyllin is a nature product that could be isolated from Hyptis wticillata.β-Apopicropodophyllin induces apoptosis by inducing microtubule disruption, DNA damage, cell cycle arrest and ER stress. β-Apopicropodophyllin can be used in research of cancer [1].
|
-
- HY-118614R
-
|
|
Drug Metabolite
|
Neurological Disease
|
|
β-Nicotyrine (Standard) is the analytical standard of β-Nicotyrine. This product is intended for research and analytical applications. β-Nicotyrine is a metabolite of Nicotine.β-Nicotyrine, isolated from the leaves of Nicotiana tabacum plants and from cigarette smoke condensate, is a minor tobacco alkaloid [1].
|
-
- HY-W015084AS
-
-
- HY-P1468F
-
|
Biotin-amyloid β-protein (1-28)
|
Amyloid-β
|
Others
|
|
Biotin-β-amyloid (1-28) (Biotin-amyloid β-protein (1-28)) is abiotinylated β-Amyloid (1-28) (HY-P1468).
|
-
- HY-N14912
-
|
|
Antibiotic
Bacterial
Fungal
|
Infection
|
|
β-Prumycin hydrochloride is a carbohydrate antibiotic. β-Prumycin hydrochloride has anti-fungal activity and weak anti-individual bacterial activity.
|
-
- HY-P2869C
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
β1-3,4 Galactosidase is a highly specific exoglycosidase that catalyzes the hydrolysis of terminal β1-3 and β1-4 linked galactose residues from oligosaccharides [1].
|
-
- HY-N0941R
-
|
|
Bacterial
Parasite
Apoptosis
|
Infection
Cancer
|
|
beta-Mangostin (Standard) is the analytical standard of beta-Mangostin. This product is intended for research and analytical applications. beta-Mangostin (β-Mangostin) is a xanthone compound present in Cratoxylum arborescens, with antibacterial and antimalarial activities. beta-Mangostin exhibits antimycobacterial activity against Mycobacterium tuberculosis with an MIC of 6.25 μg/mL. beta-Mangostin possesses in vitro antimalarial activity against Plasmodium falciparum, with an IC50 of 3.00 μg/mL. beta-Mangostin has potent anticancer activity against various cancers (such as hepatocellular carcinoma, leukaemic) [1] .
|
-
- HY-N2454R
-
-
- HY-N5053
-
|
|
Others
|
Others
|
|
Periplogenin 3-[O-β-glucopyranosyl-(1→4)-β-sarmentopyranoside] is a cardenolide isolated from the root barks of Periploca sepium [1].
|
-
![Periplogenin 3-[O-β-glucopyranosyl-(1→4)-β-sarmentopyranoside]](//file.medchemexpress.com/product_pic/hy-n5053.gif)
- HY-114508
-
|
3-Phenylpropiophenone; β-Phenylpropiophenone
|
Amyloid-β
|
Neurological Disease
|
|
Dihydrochalcone (3-Phenylpropiophenone) is a BBB-penatrable Aβ aggregation inhibitor. Dihydrochalcone destabilizes Aβ17-42 protofibrils by disrupting the β-sheet of β1 region. Dihydrochalcone destabilizes both U-shaped Aβ40/Aβ42 protofibrils and S-shaped Aβ42 protofibrils by binding to the protofibril cavity. Dihydrochalcone is the main component of daemonorops draco tree [1].
|
-
- HY-N6741R
-
|
|
Others
|
Infection
Endocrinology
|
|
β-Zearalenol (Standard) is the analytical standard of β-Zearalenol. This product is intended for research and analytical applications. β-Zearalenol is a non-steroidal estrogenic mycotoxin synthesized by Fusarium species. β-Zearalenol potentially influences transcription and effects gene expression on translational level [1].
|
-
- HY-P2858
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
β-Mannosidase is a lysosomal enzyme from the glycosyl hydrolase family 2 that cleaves the single β(1-4)-linked mannose at the nonreducing end of N-glycosylated proteins, and plays an important role in the polysaccharide degradation pathway [1].
|
-
- HY-N3995
-
|
|
Apoptosis
Drug Metabolite
|
Cancer
|
|
5β-Dihydrocortisol, a metabolite of Cortisol, is a potential mineralocorticoid. 5β-Dihydrocortisol can potentiate glucocorticoid activity in raising the intraocular pressure. 5β-Dihydrocortisol causes breast cancer cell apoptosis [1] .
|
-
- HY-137870
-
|
gamma-Glutamyl-beta-naphthylamide
|
Biochemical Assay Reagents
|
Others
|
|
γ-Glutamyl-β-naphthylamide is a substrate for γ-glutamine peptidase. γ-Glutamyl-β-naphthylamide is specifically recognized and the peptide chain is cleaved. γ-Glutamyl-β-naphthylamide can be used to distinguish between gonococci and meningococci [1].
|
-
- HY-N1876
-
|
|
Others
|
Neurological Disease
|
|
Aromadendrane-4β,10α-diol is a sesquiterpene alcohol. Aromadendrane-4β,10α-diol significantly ameliorates the Aβ1-42 peptide-induced memory impairment. Aromadendrane-4β,10α-diol can be used for Alzheimer's disease (AD) research [1].
|
-
- HY-N15333
-
|
|
Insecticide
|
Infection
|
|
β-Terpinyl acetate is a compound with anti-termitic activity, which is found in Lavandula Latifolia. β-Terpinyl acetate is promising for research of termiticides [1].
|
-
- HY-108693
-
-
- HY-E70179
-
|
EC 2.4.1.149; B4GAT1; β3GNTI
|
Glucosylceramide Synthase (GCS)
|
Others
|
|
beta-1,4-Glucuronyltransferase 1 is a glucosyltransferase. beta-1,4-Glucuronyltransferase 1 transfers glucuronic acid towards both α and β anomers of xylose [1].
|
-
- HY-N8453
-
|
Methyl 3,5-dicaffeoyl quinic acid
|
p38 MAPK
|
Neurological Disease
|
|
Macranthoin G is an inhibitor of p38 MAPK. Macranthoin G protects the cytotoxicity induced by Aβ or hydrogen peroxide in neuronal cells by downregulating p38 MAPK. Macranthoin G can used in study Alzheimer’s Disease [1].
|
-
- HY-D1461
-
|
|
Fluorescent Dye
|
Cancer
|
|
Fluorescein Di-β-D-Glucopyranoside is a specific β-glucocerebrosidase substrate that can be used for the intralysosomal β-galactosidase [1].
|
-
- HY-P1772
-
-
- HY-101274A
-
-
- HY-133680R
-
|
|
Tyrosinase
|
Others
|
|
β-Tocopherol (Standard) is the analytical standard of β-Tocopherol. This product is intended for research and analytical applications. β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol [1] .
|
-
- HY-115843
-
-
- HY-125932A
-
|
|
Serotonin Transporter
|
Neurological Disease
|
|
9β-Debilon is a sesquiterpenoid compound found in Nardostachys chinensis and may possess SERT regulatory activity. Structurally, 9β-Debilon is a diastereomer of Debilon (HY-125932). 9β-Debilon holds potential for research into neurological disorders [1].
|
-
- HY-131108R
-
|
|
Others
|
Others
|
|
β-Aspartylaspartic acid (Standard) is the analytical standard of β-Aspartylaspartic acid. This product is intended for research and analytical applications. β-Aspartylaspartic acid is a natural compound found in Asparagus (Asparagus officinalis) Shoots [1].
|
-
- HY-N13547
-
|
|
Others
|
Others
|
|
3β,7β-Dihydroxy-25-methoxycucurbita-5,23-dien-19-al is a natural product [1].
|
-
- HY-N9933
-
|
TβMCA
|
FXR
Apoptosis
|
Metabolic Disease
Cancer
|
|
Tauro-β-muricholic acid (TβMCA) is a trihydroxylated bile acid. Tauro-β-muricholic acid is a competitive and reversible FXR antagonist (IC50 = 40 μM). Tauro-β-muricholic acid has antiapoptotic effect. Tauro-β-muricholic acid inhibits bile acid-induced hepatocellular apoptosis by maintaining the mitochondrial membrane potential [1] .
|
-
- HY-148133
-
|
|
GSK-3
|
Neurological Disease
|
|
GSK-3β inhibitor 12 (compound 15) is an inhibitor of GSK-3β. GSK-3β inhibitor 12 inhibits 49.11% and 37.11% activity of 25 μM and 50 μM GSK-3β, respectively. GSK-3β inhibitor 12 can be used for the research of neurodegenerative diseases [1].
|
-
- HY-42822A
-
-
- HY-N2454
-
-
- HY-N1415S
-
-
- HY-P1779A
-
|
β-Casomorphin-5 TFA
|
Opioid Receptor
|
Others
|
|
β-Casomorphin (1-5), bovine (TFA) is a peptide of bovine β-Casomorphin.
|
-
- HY-135386
-
-
- HY-N8695
-
|
|
Others
|
Cancer
|
|
1β-Hydroxybufalin is a bufadienolide that can be isolated from Ch’an Su. 1β-Hydroxybufalin inhibits cancer cell growth [1].
|
-
- HY-P2869E
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
β1-3,4,6 Galactosidase is a broad specificity exoglycosidase that catalyzes the hydrolysis of terminal, non-reducing β1-3 β1-4 and β1-6 linked galactose residues from oligosaccharides, with β1-6 linked galactose residues at a slower rate [1].
|
-
- HY-136868
-
|
3-Phenoxazone 7-(β-D-glucopyranoside),98%
|
Biochemical Assay Reagents
|
Others
|
|
Resorufin-β-D-glucopyranoside, 98% (3-Phenoxazone 7-(β-D-glucopyranoside), 98%) can be used to detect and quantify β-glucosidase activity in various biological samples.
|
-
- HY-W011654
-
|
4-Aminophenyl-beta-D-galactopyranoside, 98%
|
Biochemical Assay Reagents
|
Others
|
|
4-Aminophenyl-β-D-galactopyranoside, 98% is a biochemical reagent. 4-Aminophenyl-β-D-galactopyranoside, 98% is a substrate for β-galactosidase (HY-P2869) [1].
|
-
- HY-N0338R
-
|
|
Others
|
Others
|
|
(-)-Syringaresnol-4-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside (Standard) is the analytical standard of (-)-Syringaresnol-4-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside. This product is intended for research and analytical applications. (-)-Syringaresnol-4-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside is a lignan glycoside that can be isolated from the stem bark of Albizia julibrissin Durazz [1].
|
-
- HY-163338
-
|
|
Beta-lactamase
|
Infection
|
|
Metallo-β-lactamase-IN-13 (Compound 13i) is a pan Metallo-β-Lactamase inhibitor. Metallo-β-lactamase-IN-13 provides broader coverage of metallo-β-lactamases expressing Gram-negative (GN) bacteria. Metallo-β-lactamase-IN-13 has antibacterial activity against P. aeruginosa [1].
|
-
- HY-149858
-
|
|
Wnt
|
Cancer
|
|
β-catenin-IN-7 (Compound 9) is a β-catenin inhibitor. β-catenin-IN-7 inhibits the interaction between β-catenin and Tcf-4, and inhibits Wnt-dependent target gene expression. β-catenin-IN-7 has anti-cancer activity [1].
|
-
- HY-W107585
-
-
- HY-P5946
-
-
- HY-148132
-
|
|
GSK-3
|
Neurological Disease
|
|
GSK-3β inhibitor 11 (compound 21) is a glycogen synthase kinase-3β (GSK-3β) inhibitor (IC50=10.02 μM). GSK-3β inhibitor 11 can be used in neurodegenerative disease research [1].
|
-
- HY-133680
-
|
|
Tyrosinase
|
Others
|
|
β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol [1] .
|
-
- HY-105058A
-
|
14α/β-RU 24722
|
Others
|
Neurological Disease
|
|
14α/β-Vindeburnol (14α/β-RU 24722) a synthetic molecule derived from the eburnamine-vincamine alkaloid group, has many neuropsychopharmacological and antidepressant-like effects [1].
|
-
- HY-113319
-
|
|
Endogenous Metabolite
|
Cancer
|
|
β-D-Fructose is a β-fruit sugar that can be produced by the hydrolysis of sucrose. β-D-Fructose can be used as a sweetness potentiator. β-D-Fructose can be designed as a units of antiproliferative agents against breast (MCF-7) and colon (MDST8) cancer cell lines [1].
|
-
- HY-N10013R
-
|
|
Insecticide
|
Others
|
|
β-Damascone (Standard) is the analytical standard of β-Damascone. This product is intended for research and analytical applications. β-Damascone is an aroma active rice volatile and is widely used in perfume compositions. β-Damascone has also received certain attention as a potential cancer chemopreventive and a mosquito and muscoid insecticide [1] .
|
-
- HY-P4886A
-
|
|
Amyloid-β
|
Neurological Disease
|
|
Amyloid β-Protein (3-42) TFA is a precursor of Pyr peptide. Pyroglutamic acid-modified Aβ (pEAβ) (3-42) is the core of the amyloid plaque in Alzheimer's disease. pEAβ (3-42) accelerates the aggregation of Aβ(1-42), while Aβ(1-42) significantly slows down the primary and secondary nucleation of pEAβ(3-42).
|
-
- HY-168857
-
|
|
GSK-3
Tau Protein
β-catenin
|
Neurological Disease
|
|
GSK-3β inhibitor 24 (Compound 41) is a potent GSK-3β inhibitor with an IC50 of 0.22 nM. GSK-3β inhibitor 24 increases GSK-3β phosphorylation at Ser9 site dose-dependently. GSK-3β inhibitor 24 inhibits the hyperphosphorylation of tau protein by decreasing the p-tau-Ser396 abundance. GSK-3β inhibitor 24 up-regulates β-catenin and neurogenesis-related markers (GAP43 and MAP-2). GSK-3β inhibitor 24 demonstrates remarkable anti-Alzheimer's disease (AD) effects [1].
|
-
- HY-137827
-
|
p-Nitrophenyl β-D-Cellobioside
|
Fluorescent Dye
|
Others
|
|
4-Nitrophenyl β-D-Cellobioside (p-Nitrophenyl β-D-cellobioside) is a cellotriose analog, a chromogenic substrate for the detection of cellulase activity. Exoglucanases, endoglucanases, and β-glucosidases hydrolyze 4-Nitrophenyl β-D-Cellobioside to yield p-nitrophenol (PNP) [1] .
|
-
- HY-153637
-
|
|
Thyroid Hormone Receptor
|
Endocrinology
|
|
THR-β modulator-1 (compound 1a) is a potent thyroid hormone receptor β modulator. THR-β modulator-1 can be used in research of thyroid hormone receptor related disorders [1].
|
-
- HY-149282
-
-
- HY-149281
-
-
- HY-N7682
-
|
|
Fungal
|
Others
|
|
β-Tomatine is a breakdown product of α-tomatine and a less fungitoxic compound. β-Tomatine can suppress plant defense responses [1].
|
-
- HY-N13719
-
|
|
Others
|
Others
|
|
Tectorigenin 7-O-β-D-glucosyl-(1→6)-β-D-glucoside is an active compound.
|
-
- HY-N0411R
-
|
|
Endogenous Metabolite
Apoptosis
Reactive Oxygen Species
|
Metabolic Disease
Cancer
|
|
β-Carotene (Standard) is the analytical standard of β-Carotene. This product is intended for research and analytical applications. β-Carotene (Provitamin A), a carotenoid compound, is a naturally-occurring vitamin A precursor. β-Carotene is a modulator of reactive oxygen species (ROS), with antioxidant and antiinflammatory activities. β-Carotene may serve as an antioxidant or as a prooxidant, depending on its intrinsic properties as well as on the redox potential of the biological environment in which it acts. β-Carotene induces breast cancer cells apoptosis, with anticancer activities [1] .
|
-
- HY-172171
-
|
|
GSK-3
β-catenin
Wnt
|
Neurological Disease
|
|
GSK3β-IN-2 (Compound S01) is the inhibitor for GSK3β with an IC50 of 0.35 nM. GSK3β-IN-2 activates Wnt/β-catenin signaling pathway, promotes neurogenesis and neurite growth. GSK3β-IN-2 inhibits Aβ-induced tau hyperphosphorylation at Ser396, reduces the formation of neurofibrillary tangles. GSK3β-IN-2 ameliorates Alzheimer's Disease in zebrafish model [1].
|
-
- HY-130842
-
|
β-NF-CH2-Br
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
β-Naphthoflavone-CH2-Br (β-NF-CH2-Br) is an arylhydrocarbon receptor (AhR) ligand. β-Naphthoflavone-CH2-Br can be used to synthesize the PROTAC β-NF-JQ1(HY-130256) [1].
|
-
- HY-N8214
-
|
|
Others
|
Cardiovascular Disease
|
|
Isorhamnetin 3-O-β-D-glucose-7-O-β-D-gentiobioside is a bioactive constituent that can be found in the seeds of Lepidium apetalum Willd. Isorhamnetin 3-O-β-D-glucose-7-O-β-D-gentiobioside exhibits significant triglyceride (TG)-lowering effects in HepG2 cells [1].
|
-
- HY-114740
-
|
5,6-Benzoflavone; beta-NF
|
Aryl Hydrocarbon Receptor
Apoptosis
|
Neurological Disease
Cancer
|
|
β-Naphthoflavone is an exogenous aryl hydrocarbon receptor (AHR) ligand. β-Naphthoflavone can activate AHR to participate in various biological processes, including cell growth, differentiation, apoptosis, and metabolism. β-Naphthoflavone has antioxidant activity and can exert its antioxidant function by regulating the activity of antioxidant enzymes. β-Naphthoflavone is also a non-carcinogenic CYP1A inducer and can be used to treat aristolochic acid (AAI) induced renal injury [1] .
|
-
- HY-N9521
-
|
|
Others
|
Cancer
|
|
3-O-β-D-Glucopyranosyl(1→2)-[a-Lrhamnopyranosyl(1→3)]-β-D-glucopyranosyl 28-O-β-D-glucuronopyranoside, a saponin, is isolated from Polaskia chichipe Backbg. 3-O-β-D-Glucopyranosyl(1→2)-[a-Lrhamnopyranosyl(1→3)]-β-D-glucopyranosyl 28-O-β-D-glucuronopyranoside shows ability to inhibit melanin biosynthesis by B16 melanoma cell with inhibitory activity 84.2% at 100μM[1].
|
-
![3-O-β-D-Glucopyranosyl(1→2)-[a-Lrhamnopyranosyl(1→3)]-β-D-glucopyranosyl 28-O-β-D-glucuronopyranoside](//file.medchemexpress.com/product_pic/hy-n9521.gif)
- HY-158977
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
β-Lactamase-IN-9 (compound 2) is a β-lactamase inhibitor that can restore the sensitivity of pathogens to β-lactam antibiotics [1].
|
-
- HY-W698354
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Gal1-β-3GlcNAc1-β-Ome is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology [1].
|
-
- HY-W291131
-
|
IBT
|
HSV
Orthopoxvirus
|
Infection
|
|
Isatin-β-thiosemicarbazone is a potent anti-poxvirus agent (including monkeypox virus, orthopoxvirus, vaccinia virus, etc). Isatin-β-thiosemicarbazone also is a potent herpes simplex virus (HSV) inhibitor. Isatin-β-thiosemicarbazone exhibits
|
-
- HY-135577R
-
|
|
Drug Metabolite
|
Infection
|
|
β-Apooxytetracycline (Standard) is the analytical standard of β-Apooxytetracycline. This product is intended for research and analytical applications. β-Apooxytetracycline is a degradation product of Oxytetracycline (HY-B0275). Oxytetracycline is a widespread antibiotic [1].
|
-
- HY-18500
-
|
|
Drug Isomer
|
Others
|
|
(βS)-β-Hydroxy-L-histidine hydrochloride is a stereoisomer of β-hydroxyhistidine [1].
|
-
- HY-137249
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Resorufin-β-D-galactopyranoside is a commonly used substrate in various biochemical assays to measure the activity of β-galactosidase, an important enzyme involved in lactose metabolism and regulation of gene expression. Resorufin-β-D-galactopyranoside has unique chemical properties and can be hydrolyzed by β-galactosidase to form a red fluorescent product called resorufin. This makes it a useful tool for detecting and quantifying β-galactosidase activity in biological samples such as bacteria or mammalian cells.
|
-
- HY-133969
-
|
|
FXR
|
Metabolic Disease
|
|
5β-Cholane is a farnesoid X receptor (FXR) activator. 5β-Cholane can be used for the research of cholesterol and lipid-related diseases [1].
|
-
- HY-118614
-
|
|
Drug Metabolite
|
Neurological Disease
|
|
β-Nicotyrine is a metabolite of Nicotine.β-Nicotyrine, isolated from the leaves of Nicotiana tabacum plants and from cigarette smoke condensate, is a minor tobacco alkaloid [1].
|
-
- HY-N12378
-
|
|
Others
|
Inflammation/Immunology
|
|
β-Patchoulene is a tricyclic sesquiterpene isolated from the oil of Pogostemon cablin (patchouli oil). β-Patchoulene
can be used for the treatment of inflammatory diseases [1].
|
-
- HY-125773
-
|
beta-cyano-l-alanine
|
Endogenous Metabolite
|
Neurological Disease
|
|
β-cyano-L-Alanine (Beta-cyano-l-alanine), a nitrile of widespread occurrence in higher plants, is enzymatically produced by cyanoalanine synthase from cyanide and cysteine as substrates [1]. β-cyano-L-Alanine abolishes the protective effect of ethanol on cerebral ischemia/reperfusion (I/R) injury .
|
-
- HY-N13329
-
|
|
Others
|
Others
|
|
Orcinol 1-O-beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside is a natural product [1].
|
-
- HY-N3808
-
|
|
Others
|
Others
|
|
(4α,11β,15β)-11,15-Dihydroxykaur-16-en-19-oic acid is a compound isolated from the Tunisian Pulicaria laciniata (Coss.et Kral.) Thell. flowers [1].
|
-
- HY-W744666
-
-
- HY-W015084R
-
|
|
Apoptosis
|
Cancer
|
|
β-Ionone (Standard) is the analytical standard of β-Ionone. This product is intended for research and analytical applications. β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. Anti-cancer activity [1].
|
-
- HY-141626S
-
-
- HY-101514
-
|
|
Adrenergic Receptor
|
Cardiovascular Disease
Endocrinology
|
|
β3-AR agonist 1 (compound 15) is a highly potent, selective, and orally available β3-adrenergic receptor (β3-AR) agonist (EC50=18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/β3, and α1A/β3>556-fold) [1].
|
-
- HY-N1688
-
|
|
Others
|
Others
|
|
24-Norhopa-4(23),22(29)-diene-3β,6β-diol is a Triterpenoids product that can be isolated from the herbs of Dodonaea viscosa [1].
|
-
- HY-N9443
-
|
|
Others
|
Others
|
|
(12β)-20-(β-D-Glucopyranosyloxy)-12-hydroxydammar-24-en-3-one is a natural product that can be found in Cladosporium microorganisms [1].
|
-
- HY-N10867
-
|
|
Others
|
Others
|
|
β-Acids colupulone is the bitter substance. β-Acids colupulone can be isolated from hops [1].
|
-
- HY-130795
-
|
|
GSK-3
|
Neurological Disease
|
|
GSK-3β inhibitor 2 (Compound 3) is a potent, selective and orally active GSK-3β inhibitor with an IC50 of 1.1 nM. GSK-3β inhibitor 2 can cross the blood-brain barrier. GSK-3β inhibitor 2 has the potential for Alzheimer's disease [1].
|
-
- HY-120902
-
|
|
Wnt
GSK-3
|
Inflammation/Immunology
|
|
GSK-3β inhibitor 8, a thiophenacil derivative, is an effective and selective inhibitor of GSK-3β (IC50=64 nM). GSK-3β inhibitor 8 negatively regulated Wnt signaling pathway and stimulated β cell proliferation [1] .
|
-
- HY-163896
-
|
|
β-catenin
|
Cancer
|
|
β-Catenin modulator-7 (Compound 5) is a modulator for β-catenin. β-Catenin modulator-7 inhibits the expression of β-catenin in HCT-116 cytoplasm and nucleus, suppresses the phosphorylation of GSK 3β. β-Catenin modulator-7 promotes NO release in HCT-116, and inhibits the proliferation of cancer cell HCT-116 with IC50 of 0.6-0.9 μM. β-Catenin modulator-7 can be used in reasearch about colon cancer [1].
|
-
- HY-N13497
-
|
|
Others
|
Others
|
|
3β,7β,19-Trihydroxy-25-methoxycucurbita-5,23-diene 7-O-glucoside is a triterpenoid product that can be isolated from Momordica charantia [1].
|
-
- HY-P1502F
-
|
|
Opioid Receptor
|
Neurological Disease
|
|
Biocytin-β-endorphin, human is abiotinylated β-Endorphin, human (HY-P1502). β-Endorphin, human, a prominent endogenous peptide, existing in the hypophysis cerebri and hypothalamus, is an agonist of opioid receptor, with preferred affinity for μ-opioid receptor and δ-opioid receptor; β-Endorphin, human exhibits antinociception activity.
|
-
- HY-107201A
-
|
betadex hydrate
|
Biochemical Assay Reagents
|
Others
|
|
β-Cyclodextrin hydrate (Betadex hydrate) is a cyclic oligosaccharide composed of seven glucose units, featuring a hydrophobic central cavity and a hydrophilic outer surface. β-Cyclodextrin hydrate is utilized in an immunoassay method that leverages the complex formed by β-Cyclodextrin hydrate with small molecules to enhance the sensitivity of the immunodetection for these small molecules. β-Cyclodextrin hydrate is applicable for research in biosensing and immunoanalysis [1].
|
-
- HY-P1880
-
-
- HY-P1891
-
-
- HY-P1879
-
-
- HY-P1893
-
-
- HY-N6741
-
|
|
Others
|
Infection
Endocrinology
|
|
β-Zearalenol is a non-steroidal estrogenic mycotoxin synthesized by Fusarium species. β-Zearalenol potentially influences transcription and effects gene expression on translational level [1].
|
-
- HY-131405
-
|
|
Apoptosis
Bcl-2 Family
|
Cancer
|
|
β-Eleostearic acid is an apoptosis inducer with antiproliferative properties. β-Eleostearic acid down-regulates and up-regulates the mRNA levels of Bcl-2 and Bax, respectively [1].
|
-
- HY-136552
-
|
|
Others
|
Cancer
|
|
β-Bisabolene is a sesquiterpene isolated from opoponax (Commiphora guidotti). β-Bisabolene, an anti-cancer agent, can be used for the study of breast cancer [1].
|
-
- HY-N15410
-
|
|
Endogenous Metabolite
|
Others
|
|
β-Cotonefuran is a dibenzofuran phytoalexin produced by plants in response to biotic and abiotic stresses. β-Cotonefuran can be used in the study of Arabidopsis thaliana's response to salt stress [1].
|
-
- HY-164907
-
|
|
GSK-3
|
Neurological Disease
|
|
GSK-3β inhibitor 22 (compound 20o) is a GSK-3β inhibitor with an IC50 of 3.1 nM. GSK-3β inhibitor 22 has the potential of the study of Alzheimer's disease [1].
|
-
- HY-N1810
-
|
3α,6β-Ditigloyloxytropan-7β-ol
|
Others
|
Others
|
|
Ditigloylteloidine (3α,6β-Ditigloyloxytropan-7β-ol) is a Sesquiterpenoids product that can be isolated from the herbs of Eupatorium chinense var. tozanense. [1].
|
-
- HY-20696R
-
|
|
5-HT Receptor
|
Metabolic Disease
|
|
Tetrahydro-β-carboline (Standard) is the analytical standard of Tetrahydro-β-carboline. This product is intended for research and analytical applications. Tetrahydro-β-carboline (Tryptoline) is a metabolite of tryptamine, also is a competitive serotonin reuptake inhibitor with an Ki value of 6.1 μM [1].
|
-
- HY-113478
-
|
Isoursodeoxycholic acid
|
Drug Metabolite
|
Metabolic Disease
|
|
3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) is a bile acid. 3β-Ursodeoxycholic acid shows good tolerance and well intestinal absorption by oral adminstation. 3β-Ursodeoxycholic acid can be isomerized by intestinal and hepatic enzymes to yield UDCA [1].
|
-
- HY-N1415R
-
-
- HY-P3319
-
|
|
iGluR
|
Neurological Disease
|
|
β-Neuroprotectin is a (3H)TCP binding inhibitor with activity against NMDA-mediated neuronal cell death. β-Neuroprotectin can effectively inhibit the binding of [3H]TCP. β-Neuroprotectin provides neuroprotection at low concentrations against NMDA-induced neuronal cell death [1].
|
-
- HY-N13491
-
|
|
Others
|
Others
|
|
3β-Hydroxy-7β,25-dimethoxycucurbita-5,23-dien-19-al is a triterpenoid product that can be isolated from Momordica charantia [1].
|
-
- HY-P1362
-
|
Amyloid β Peptide (42-1)(human)
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (42-1), human is the inactive form of Amyloid β Peptide (1-42). Its active form, β-Amyloid (1-42), may play a key role in the pathogenesis of Alzheimer's disease [1].
|
-
- HY-14679
-
|
|
GSK-3
|
Neurological Disease
|
|
GSK3β inhibitor II is an inhibitor of GSK3β. GSK3β inhibitor II can be used for research of Alzheimer’s disease (AD) [1].
|
-
- HY-P2803B
-
|
|
β-glucuronidase
|
Metabolic Disease
|
|
Beta-glucuronidase (helix pomatia) is a glycosyl hydrolase that hydrolyzes β-glucuronic acid and sulfate esters in urine and other biological fluids, and then releases β-glucuronate [1].
|
-
- HY-135670A
-
|
|
Glycosidase
|
Metabolic Disease
|
|
β-glycosidase-IN-1 (Compound 33) is a piperidine derivative and a β-glycosidase inhibitor. β-glycosidase-IN-1 has hypoglycemic activity [1].
|
-
- HY-141480
-
|
|
GSK-3
Apoptosis
|
Cancer
|
|
GSK-3β inhibitor 3 is a potent, selective, irreversible and covalent inhibitor of Glycogen Synthase Kinase 3β (GSK-3β), with an IC50 of 6.6 μM. GSK-3β inhibitor 3 can be used for the research of acute promyelocytic leukemia [1].
|
-
- HY-N13525
-
|
|
Others
|
Others
|
|
Neochlorogenin6-O-β-D-xylopyranosyl-(1→3)-β-D-quinovopyranoside is a natural product [1].
|
-
- HY-N3995S
-
|
|
Apoptosis
Drug Metabolite
|
Cancer
|
|
5β-Dihydrocortisol-d6 is the deuterium labeled 5β-Dihydrocortisol. 5β-Dihydrocortisol, a metabolite of Cortisol, is a potential mineralocorticoid. 5β-Dihydrocortisol can potentiate glucocorticoid activity in raising the intraocular pressure. 5β-Dihydrocortisol causes breast cancer cell apoptosis[1][2][3][4][5].
|
-
- HY-169348
-
|
|
β-catenin
Wnt
c-Myc
|
Cancer
|
|
β-catenin-IN-8 (Compound 25) is a β-catenin inhibitor. β-catenin-IN-8 inhibits β-catenin and c-Myc protein levels, and inhibits Wnt-target genes level (Fgf20 and Sall4). β-catenin-IN-8 has colorectal cancer anticancer activities, and has metabolic stability [1].
|
-
- HY-138111
-
|
p-Nitopheyl β-D-cellotetaoside
|
Fluorescent Dye
|
Others
|
|
4-Nitrophenyl β-D-cellotetraoside (p-Nitopheyl β-D-cellotetaoside) is a small molecule cellulose mimetic consisting of a tetramer of D-glucose units linked by β-1-4 glycosidic bonds. The fragmentation pattern of 4-Nitrophenyl β-D-cellotetraoside after enzymatic hydrolysis can be analyzed by TLC or by the release of 4-nitrophenol, which has a strong absorbance at 395 nm in alkaline solutions. 4-Nitrophenyl β-D-cellotetraoside can be used in cellulose degradation studies to determine the specificity of cellulases [1].
|
-
- HY-156297
-
|
|
Proteasome
|
Inflammation/Immunology
|
|
β5i-IN-1 is a potent and selective inhibitor of β5i with a IC50 of 8.463 nM. β5i-IN-1 releases TNF-α and IL-6 and influences the transcriptional activity of NF-κB. β5i-IN-1 can be used in study idiopathic pulmonary fibrosis [1].
|
-
- HY-169024
-
-
- HY-143261
-
|
|
GSK-3
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
GSK-3β inhibitor 7 is a GSK-3β inhibitor with an IC50 value of 5.25 μM. GSK-3β inhibitor 7 is inserted into the ATP-binding binding pocket of GSK-3β and forms hydrogen-bond. GSK-3β inhibitor 7 shows high hepatocyte glucose uptake (83.5%), and can be used in the research of numerous diseases like diabetes, inflammation, cancer, Alzheimer's disease, and bipolar disorder [1].
|
-
- HY-N1501R
-
|
|
α-synuclein
Reference Standards
|
Cardiovascular Disease
Neurological Disease
Inflammation/Immunology
|
|
Beta-asarone (Standard) is the analytical standard of Beta-asarone. This product is intended for research and analytical applications. Beta-asarone is an orally active and BBB-penetrable anti-inflammatory agent and neuroprotective agent, which is the major ingredient of Acorus tatarinowii Schott. Beta-asarone can protect nerve cells from apoptosis and autophagy, inhibit expression of α-synuclein, as well as myocardial protection. Beta-asarone can be used in the study of neurological and cardiovascular diseases [1].
|
-
- HY-N2513R
-
|
|
Lipoxygenase
DNA/RNA Synthesis
|
Cancer
|
|
β-Boswellic acid (Standard) is the analytical standard of β-Boswellic acid. This product is intended for research and analytical applications. β-Boswellic acid is isolated from the gum resin of Boswellia serrata. β-Boswellic acid is a nonreducing-type inhibitor of the 5-lipoxygenase (5-LO) product formation either interacting directly with the 5-LO or blocking its translocation [1]. β-Boswellic acid inhibits the synthesis of DNA, RNA and protein in human leukemia HL-60 cells .
|
-
- HY-163748
-
|
|
GSK-3
|
Inflammation/Immunology
|
|
GSK-3β inhibitor 17 (compound 5 n) is a potent GSK-3β inhibitor. GSK-3β inhibitor 17 decreases cisplatin (HY-17394) induced p-p65, KIM-1 protein and mRNA expression. GSK-3β inhibitor 17 decreases cisplatin induced TNF-α, IL-1β, IL-6 and MCP-1 mRNA expression. GSK-3β inhibitor 17 shows anti-inflammation effect and has the potential for the research of acute kidney injury [1].
|
-
- HY-N8029
-
|
|
Others
|
Others
|
|
6-Hydroxyapigenin 6-O-β-D-glucoside-7-O-β-D-glucuronide (compound 8) is a kind of flavonoid. 6-Hydroxyapigenin 6-O-β-D-glucoside-7-O-β-D-glucuronide can be isolated from the water extract of Carthamus tinctorius [1].
|
-
- HY-P1962
-
|
[Asn670, Sta671, Val672]-Amyloid β Peptide (662-675)
|
Beta-secretase
|
Neurological Disease
|
|
β-Secretase inhibitor ([Asn670, Sta671, Val672]-Amyloid β Peptide (662-675)) is a β-secretase and BACE1 inhibitor (IC50: 25 nM for β-secretase) [1].
|
-
- HY-P1047
-
|
[Pro18, Asp21] β-Amyloid (17-21)
|
Amyloid-β
|
Neurological Disease
|
|
β-Sheet Breaker Peptide iAβ5 is an effective brain amyloid-β (Abeta) degrader. Abeta deposits are associated with Alzheimer's disease (AD), and the related toxicity arises from its β-sheet conformation and aggregation. β-Sheet Breaker Peptide iAβ5 can repeatedly induce the degradation of fibrillary amyloid deposits in vivo. Therefore, β-Sheet Breaker Peptide iAβ5 can prevent and/or reverse neuronal contraction caused by Abeta and reduce the range of interleukin IL-1beta positive microglial-like cells around Abeta deposits. β-Sheet Breaker Peptide iAβ5 can reduce the size and/or number of brain amyloid plaques in AD. β-Sheet Breaker Peptide iAβ5 is labeled with a hydrophobic benzyl alcohol (HBA) tag and shows a bright blue color under acidic conditions, which can be used for quantitative determination.
|
-
- HY-P2551
-
|
|
Amyloid-β
|
Neurological Disease
|
|
Biotin-β-Amyloid (17-40) is a N-terminal-labelled biotinylated amyloid-β(1-40) peptide. β-Amyloid (17-40) is a 24-residue fragment of the Aβ protein via post-translational processing of amyloid precursor protein (APP) [1].
|
-
- HY-172599
-
|
|
GSK-3
|
Neurological Disease
|
|
GSK-3β probe-1 (10c) is a GSK-3β probe (Ex = 341 nm, Em= 574nm, ɛ= 3.51 × 10 4L/mol·cm −1) and can be be used in the study of Alzheimer's disease [1].
|
-
- HY-136234
-
|
|
Endogenous Metabolite
|
Others
|
|
9-cis-β-Carotene, a precursor of retinal, is cleaved by beta-carotene oxygenase 1 (BCMO1) to produce 9-cis-retinal. 9-cis-β-Carotene inhibits photoreceptor degeneration and restores retinal function in vivo. 9-cis-β-Carotene has the potential for the study of congenital stationary night blindness and fundus albipunctatus [1].
|
-
- HY-P1474A
-
|
Amyloid β-Protein (22-35) (TFA)
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid 22-35 (Amyloid β-Protein 22-35) TFA, the residues 22-35 fragment ofβ-amyloid protein, has a cytotoxic effect on cultured neurons from the rat hippocampus in serum-free medium. β-Amyloid 22-35 TFA forms aggregates and typical amyloid fibrils resembling those of the β-amyloid protein in neutral buffer solution) [1].
|
-
- HY-N15237
-
|
Allyl β-D-lactose
|
Biochemical Assay Reagents
|
Others
|
|
Allyl β-lactoside (Allyl β-D-lactose) is a lactoside, which can be generated by incubating lactose and allyl alcohol with cellulase preparation, and can be used as a starting material for the synthesis of glycopolymers [1].
|
-
- HY-156485S
-
-
- HY-P0179A
-
-
- HY-130522
-
|
6β-PGI1
|
Prostaglandin Receptor
|
Others
|
|
6β-Prostaglandin I1 (6β-PGI1) is an analog of prostaglandin I2 (PGI2) that is resistant to hydrolysis in aqueous solutions. 6β-Prostaglandin I1 can reduce gastric acid secretion with an ID50 (dose causing 50% inhibition) of approximately 3.0 μg/kg/min (intravenous injection) [1].
|
-
- HY-N13444
-
|
|
Others
|
Others
|
|
10β-Hydroxycadina-4,11(13)-dien-12,8β-olide is a natural product [1].
|
-
- HY-113068S
-
|
|
Isotope-Labeled Compounds
Tyrosinase
|
Metabolic Disease
|
|
β-Tocopherol-d3 is the deuterium labeled β-Tocopherol. β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol can also prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol[1][2][3].
|
-
- HY-133680S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
β-Tocopherol-d4 is a deuterium labeled β-Tocopherol (HY-133680). β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol [1].
|
-
- HY-W357154
-
|
4-Methylumbelliferyl beta-L-fucopyranoside
|
Biochemical Assay Reagents
|
Others
|
|
Methylumbelliferyl β-L-fucoside (4-Methylumbelliferyl beta-L-fucopyranoside) is a derivative of fucose that can be used in glycobiology research.
|
-
- HY-147134
-
|
|
GSK-3
|
Neurological Disease
|
|
GSK-3β inhibitor 10 (compound 14a) is a highly potent GSK-3β inhibitor with an IC50 value of 80.5 nM. GSK-3β inhibitor 10 can be used for researching Alzheimer’s disease [1].
|
-
- HY-169602
-
-
- HY-P10037
-
|
|
Amyloid-β
|
Neurological Disease
|
|
β Amyloid(17-28) human is a β-amyloid peptide (Abeta), a lipid-induced amyloid core fragment. β Amyloid(17-28) human enhances aggregation of full-length β Amyloid40, producing toxic aggregates in Alzheimer's disease (AD) [1].
|
-
- HY-N0180R
-
|
|
Endogenous Metabolite
|
Inflammation/Immunology
Cancer
|
|
18β-Glycyrrhetinic acid (Standard) is the analytical standard of 18β-Glycyrrhetinic acid. This product is intended for research and analytical applications. 18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhiza uralensis and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.
|
-
- HY-P2775
-
|
|
Glycosidase
|
Others
|
|
β-Glucosidase, almond is the rate-limiting enzyme in cellulose degradation. β-Glucosidase is a major group among glycoside hydrolases. β-Glucosidase is involved in the degradation of cellulose in soils and has potential for monitoring soil quality [1] .
|
-
- HY-P0128A
-
|
Amyloid beta-peptide (25-35), HFIP-treated; Aβ25-35, HFIP-treated; β-Amyloid peptide (25-35), HFIP-treated
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (25-35) (Amyloid beta-peptide (25-35)), HFIP-treated is a β-Amyloid (25-35) (HY-P0128) treated with HFIP. β-Amyloid (25-35) (Amyloid beta-peptide (25-35)) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide, has shown neurotoxic activities in cultured cells [1].
|
-
- HY-N13142
-
|
|
Others
|
Inflammation/Immunology
|
|
Luteolin 7-O-[β-D-apiofuranosyl-(1→6)]-β-D-glucopyranoside (compound 3) is a flavonoid with antioxidant activity, which can be isolated from Margaritopsis carrascoana. Luteolin 7-O-[β-D-apiofuranosyl-(1→6)]-β-D-glucopyranoside has good DPPH free radical scavenging activity (IC50=0.188 mg/mL) [1].
|
-
![Luteolin 7-O-[β-D-apiofuranosyl-(1→6)]-β-D-glucopyranoside](//file.medchemexpress.com/product_pic/hy-n13142.gif)
- HY-N7907
-
|
|
Others
|
Metabolic Disease
|
|
Myricetin-3-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranoside is a natural product that can be obtained from sphaerophysa salsula. Myricetin-3-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranoside inhibits triglyceride (TG) accumulation in 3T3-L1 adipocytes [1] .
|
-
- HY-W039938
-
|
|
Fluorescent Dye
|
Others
|
|
4-Nitrophenyl β-D-xylopyranoside is a chromogenic β-xylosidase substrate. 4-Nitrophenyl β-D-xylopyranoside can be used to test β-xylosidase activity [1].
|
-
- HY-W013254
-
|
|
Glycosidase
|
Others
|
|
2-Nitrophenyl β-D-glucopyranoside is a substrate for β-glucosidase. 2-Nitrophenyl β-D-glucopyranoside can be used to test β-glucosidase activity [1] .
|
-
- HY-N8987
-
|
|
Others
|
Others
|
|
(3β,7β)-3,7,23,24-Tetrahydroxycucurbita-5,25-dien-19-al (compound 3) is a cucurbitane-type triterpenoid isolated from the vines and leaves of Momordica charantia [1].
|
-
- HY-143260
-
|
|
GSK-3
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
GSK-3β inhibitor 6 is a potent GSK-3β inhibitor with an IC50 value of 24.4 μM. GSK-3β inhibitor 6 shows high hepatocyte glucose uptake (38%). GSK-3β inhibitor 6 can be used in the research of numerous diseases like diabetes, inflammation, cancer, Alzheimer's disease, and bipolar disorder [1].
|
-
- HY-P3966
-
-
- HY-P1787
-
|
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (4-10) is an epitope for the polyclonal anti-Aβ(1-42) antibody, reduces amyloid deposition in a transgenic Alzheimer disease mouse model [1].
|
-
- HY-W699926
-
|
(R)-Naproxen-β-D-glucuronide
|
Biochemical Assay Reagents
|
|
|
(R)-Naproxen acyl-β-D-glucuronide ((R)-Naproxen-β-D-glucuronide) is a compound metabolite with anti-inflammatory activity. (R)-Naproxen acyl-β-D-glucuronide can serve as a sensitive fluorescent substrate for proglutamyl peptidase 1, which produces a blue reaction after cleavage.
|
-
- HY-W008234
-
|
|
Biochemical Assay Reagents
|
Inflammation/Immunology
|
|
N-Phthaloyl-β-alanine (hapten FP) is an FX-type hapten without CH2S moiety. N-Phthaloyl-β-alanine can be coupled to OVA using the mixed anhydride method. N-Phthaloyl-β-alanine has more heterologies [1].
|
-
- HY-D1460
-
|
|
β-glucuronidase
Bacterial
|
Infection
|
|
Fluorescein Di-β-D-Glucuronide, a fluorescent probe, can be utilized to non-invasively image the intestinal bacterial β-glucuronidase activity in nude mice. Fluorescein Di-β-D-Glucuronide-based imaging reveals the in vitro and in vivo activity of intestinal bacterial β-glucuronidase, which would facilitate pharmacodynamic studies of specific bacterial β-glucuronidase inhibitors in animal studies [1].
|
-
- HY-P1867
-
-
- HY-W779188
-
-
- HY-152057S
-
-
- HY-137783
-
-
- HY-134353B
-
|
Adenosine 5'-β-thiodiphosphate (trilithium)
|
P2Y Receptor
NF-κB
|
Inflammation/Immunology
|
|
ADP-β-S trilithium is the trilithium salt form of ADP-β-S (HY-134353). ADP-β-S trilithium is the activator for P2Y12 receptor, which upregulates levels of IL-1βand IL-6 production in microglial cells, promotes the phosphorylation and nuclear translocation of NF-κB, and enhances the activation of the NLRP3 inflammasome [1].
|
-
- HY-160078
-
|
|
Others
|
Metabolic Disease
|
|
Deferiprone O-β-D-glucuronide is a novel orally active iron chelator. Deferiprone O-β-D-glucuronide shows the capability of reducing the iron burden in patients with β-thalassemia [1].
|
-
- HY-137909
-
-
- HY-W751152R
-
|
|
Others
|
Cancer
|
|
α,β-Thujone (Standard) is the analytical standard of α,β-Thujone. This product is intended for research and analytical applications. α,β-Thujone is a component of the essential oils of some plants. α,β-Thujone causes cancers in male rats and induces seizures in the highest doses [1].
|
-
- HY-W150340
-
|
|
Galectin
Biochemical Assay Reagents
|
Cancer
|
|
β-Lactose is a disaccharide commonly found in milk and dairy products. It consists of two monosaccharides, glucose and galactose, linked by β-glycosidic bonds. β-Lactose has various applications in the food industry, especially as a sweetener and bulking agent. Furthermore, it can be used as a substrate for enzymes involved in lactose metabolism and as a model compound for studying carbohydrate-protein interactions.
|
-
- HY-P3489
-
|
|
Melanocortin Receptor
|
Endocrinology
|
|
β-Corticotropin (swine) is a synthetic form of the peptide hormone corticotropin (ACTH). β-Corticotropin stimulates steroid release [1] .
|
-
- HY-N10493
-
-
- HY-66007
-
-
- HY-126144
-
|
|
GSK-3
|
Metabolic Disease
Cancer
|
|
GSK-3β inhibitor 1 (compound 3a) inhibits GSK-3β with an IC50 of 4.19 nM. GSK-3β inhibitor 1 demonstrates high antidiabetic efficacy in obese Streptozotocin (HY-13753)-treated rats [1].
|
-
- HY-N6652R
-
|
|
Others
|
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
|
1-beta-D-Arabinofuranosyluracil (Standard) is the analytical standard of 1-beta-D-Arabinofuranosyluracil. This product is intended for research and analytical applications. 1-beta-D-Arabinofuranosyluracil (Uracil 1-β-D-arabinofuranoside) isolated from the Caribbean sponge Tectitethya crypta, is a methoxyadenosine derivative. 1-beta-D-Arabinofuranosyluracil has demonstrated a diverse bioactivity profile including anti-inflammatory activity, analgesic and vasodilation properties [1]. 1-beta-D-Arabinofuranosyluracil reduces a proliferation of mouse lymphoma cells .
|
-
- HY-149218
-
|
|
Thyroid Hormone Receptor
|
Metabolic Disease
Inflammation/Immunology
|
|
THR-β agonist 6 is an orally active, selective thyroid hormone receptor β (THR-β) agonist with EC50s of 0.03 μM and 0.22 μM for THR-β and THR-α, respectively. THR-β agonist 6 exhibits an xcellent liver-to-serum ratio of 93:1 in mice. THR-β agonist 6 has the potential for nonalcoholic steatohepatitis (NASH) research [1].
|
-
- HY-N12742
-
|
|
Others
|
Inflammation/Immunology
|
|
Tamarixetin 3-O-β-d-apiofuranosyl-(1 → 2)-β-d-galactopyranoside (compound 4) is an inhibitor of collagenase and elastase with potential anti-inflammatory activity. Tamarixetin 3-O-β-d-apiofuranosyl-(1 → 2)-β-d-galactopyranoside can be isolated from the methanol extract of the Balkan endemic species Astragalus thracicus Griseb [1].
|
-
- HY-162638
-
-
- HY-137496
-
|
|
Biochemical Assay Reagents
|
|
|
4-Methylumbelliferyl β-D-mannopyranoside is a substrate that exhibits β-mannosidase activity. 4-Methylumbelliferyl β-D-mannopyranoside can be used to study β-mannosidase deficiency. The reactivity of 4-Methylumbelliferyl β-D-mannopyranoside shows different inhibitory effects on various substrates.
|
-
- HY-129124
-
-
- HY-N1484
-
-
- HY-W001210
-
-
- HY-W738987
-
-
- HY-N13448
-
-
- HY-N2056
-
|
11-Keto-β-boswellic acid
|
Lipoxygenase
Leukotriene Receptor
NF-κB
|
Metabolic Disease
Cancer
|
|
11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production [1].
|
-
- HY-144659
-
|
|
Beta-lactamase
Apoptosis
Bacterial
|
Infection
|
|
Metallo-β-lactamase-IN-5 (compound 5c) is a potent metallo-β-lactamases (MBL) inhibitor. Metallo-β-lactamase-IN-5 shows inhibitory activity against MBLs NDM-1 and VIM-1. Metallo-β-lactamase-IN-5 inhibits HUVECs with an IC50 of 45 μg/mL. Metallo-β-lactamase-IN-5 plus Imipenem exhibits synergistic antimicrobial activity [1].
|
-
- HY-141672S1
-
|
17β-Estradiol 3-sulfate-d4 sodium
|
GABA Receptor
|
Neurological Disease
|
|
17β-Estradiol sulfate-d4 (sodium) is the deuterium labeled 17β-Estradiol sulfate 17β-Estradiol sulfate (sodium), also known as β-Estradiol 3-sulfate sodium salt, is a neuroactive steroid[1][2].
|
-
- HY-136464
-
|
|
β-catenin
|
Cancer
|
|
β-catenin-IN-2 (Compound H1B1) is a potent β-catenin inhibitor. β-catenin-IN-2 can be used for the study of colorectal cancer [1].
|
-
- HY-22306
-
|
Penta-O-acetyl-β-D-glucopyranose
|
Biochemical Assay Reagents
|
Metabolic Disease
|
|
β-D-Glucose Pentaacetate (Penta-O-acetyl-β-D-glucopyranose) is a glucose derivative, which is mainly used to explore the mechanism of insulin secretion [1].
|
-
- HY-U00391
-
-
- HY-113887S
-
-
- HY-W213592S
-
-
- HY-146996S
-
-
- HY-138112S
-
-
- HY-P1895
-
-
- HY-138112S2
-
-
- HY-138112S1
-
-
- HY-P1903
-
-
- HY-115872
-
-
- HY-P1898
-
-
- HY-162913
-
|
|
GSK-3
|
Neurological Disease
|
|
GSK-3β inhibitor 20 (compound 3A) is an potent inhibitor of GSK-3β with an IC50 value of 74.4 nM [1].
|
-
- HY-146067
-
|
|
Fungal
Reactive Oxygen Species
|
Infection
|
|
β-Nor-lapachone is a Candida glabrata antibiofilm agent. β-Nor-lapachone can stimulate ROS production, inhibits efflux activity, adhesion, biofilm formation and the metabolism of mature biofilms of Candida glabrata. β-Nor-lapachone has antifungal activity [1].
|
-
- HY-P3513
-
|
|
ERK
MMP
|
Neurological Disease
|
|
β-Neo-Endorphin is an endogenous opioid peptide. β-Neo-Endorphin is a hypothalamic “big” Leu-enkephalin of porcine origin. β-Neo-Endorphin shows activation of the Erk1/2, MMP-2 and MMP-9 [1] .
|
-
- HY-P3513A
-
|
|
ERK
MMP
|
Neurological Disease
|
|
β-Neo-Endorphin acetate is an endogenous opioid peptide. β-Neo-Endorphin acetate is a hypothalamic "big" Leu-enkephalin of porcine origin. β-Neo-Endorphin acetate shows activation of the Erk1/2, MMP-2 and MMP-9 [1] .
|
-
- HY-164745
-
|
|
Fluorescent Dye
|
Others
|
|
L-β-ethynylserine (βES) is a threonine analog. L-β-ethynylserine is efficiently incorporated into newly synthesized proteins, and allows their selective visualization or enrichment through bioorthogonal ligation to fluorescent dyes or affinity tags,
respectively.
|
-
- HY-N11972
-
|
|
Others
|
Neurological Disease
|
|
β-Maaliene can be isolated from the fresh leaves of Vitex densiflora (Maaliene) and is the main component in the isolate. β-Maaliene can significantly reduce the exercise capacity of mice at certain doses [1].
|
-
- HY-N2924
-
-
- HY-N1814
-
|
11,12-Dehydroursolic acid lactone
|
Bacterial
|
Infection
|
|
3β-Hydroxyurs-11-en-28,13β-olide (11,12-Dehydroursolic acid lactone) is a triterpenoid that can be found in Fadogia tetraquetra var. tetraquetra [1]. 3β-Hydroxyurs-11-en-28,13β-olide shows antibacterial activity [1].
|
-
- HY-10834
-
|
|
β-catenin
|
Cancer
|
|
β-catenin-IN-6 is a β-catenin inhibitor, targeting to canonical Wingless-related integration site signaling pathway. β-catenin-IN-6 inhibits human colorectal cancer cells proliferation, as well as in a β-catenin/RK3E mouse model [1] .
|
-
- HY-19773
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
β-Lactamase-IN-1 is an inhibitor of β-Lactamase extracted from patent WO2016027249A1, page 77. β-Lactamase-IN-1 can be used to prepare of tricyclic nitrogen containing compound. β-Lactamase-IN-1 can be used for the research of neisseria gonorrhea infection [1].
|
-
- HY-W587733
-
-
- HY-149054
-
|
|
GSK-3
Tau Protein
AAK1
Pim
PKC
|
Neurological Disease
|
|
GSK-3β inhibitor 13 (compound 47) is an orally active and potent GSK-3β inhibitor with blood-brain permeability. GSK-3β inhibitor 13 inhibits GSK-3β and GSK-3α with IC50s of 0.73 nM and 0.35 nM, respectively. GSK-3β inhibitor 13 significantly decreases the phosphorylation of tau (IC50=58 nM), which leads the formation of the neurofibrillary tangles associated with Alzheimer's disease [1].
|
-
- HY-W060074
-
|
|
Endogenous Metabolite
Bacterial
Tyrosinase
PERK
|
Infection
Endocrinology
|
|
1-Acetyl-β-carboline is a metabolite of Streptomyces kasugaensis and antibacterial agent. 1-Acetyl-β-carboline increases tyrosinase activity, reduces ERK phosphorylation. 1-Acetyl-β-carboline exhibits antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) strains with MICs ranging from 128 to 256 ug/mL. 1-Acetyl-β-carboline increases the melanin [1] .
|
-
- HY-W127769
-
|
Salmon-Gal
|
Fluorescent Dye
|
Others
|
|
Rose-β-D-Gal is a chromogenic substrate, is also a β-galactosidase substrate. Rose-β-D-Gal creates a pink/magenta color after the reaction and has been used for detection of β-gal activity [1] .
|
-
- HY-P3793
-
|
|
Amyloid-β
|
Neurological Disease
|
|
Amyloid β-Protein (33-42) TFA is the residues 33-42 fragment of the β-amyloid protein. Amyloid β-Protein (33-42) TFA inhibits Aβ42-induced toxicity [1].
|
-
- HY-153760
-
-
- HY-W145620
-
|
Gal[246Bn]beta(1-4)Glc[236Bn]-beta-MP
|
Biochemical Assay Reagents
|
Others
|
|
Gal[246Bn]β(1-4)Glc[236Bn]-β-MP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
![Gal[246Bn]β(1-4)Glc[236Bn]-β-MP](//file.medchemexpress.com/product_pic/hy-w145620.gif)
- HY-W145594
-
|
Gal[26bn]beta(1-4)glc[236bn]-beta-MP
|
Biochemical Assay Reagents
|
Others
|
|
Gal[26Bn]β(1-4)Glc[236Bn]-β-MP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
![Gal[26Bn]β(1-4)Glc[236Bn]-β-MP](//file.medchemexpress.com/product_pic/hy-w145594.gif)
- HY-160266
-
-
- HY-N14129
-
|
|
Bacterial
|
Infection
|
|
Citreamicin β has anti-Gram-positive aerobic and anaerobic bacterial activities [1].
|
-
- HY-116284
-
|
Methyl β-D-glucoside
|
Drug Intermediate
|
Others
|
|
Methyl β-D-glucopyranoside (Methyl β-D-glucoside) is a model glycosyl acceptor for enzymatic glycosylation reactions. Methyl β-D-glucopyranoside participates in glycoside synthesis and can react with acyl donors such as caffeic acid esters under the catalysis of specific enzymes (such as Lipozyme TL IM) to achieve acylation modification. Methyl β-D-glucopyranoside can generate biologically active derivatives (such as 6-O-caffeoyl glucoside). Methyl β-D-glucopyranoside can be used in organic synthesis and biocatalysis research, especially the efficient enzymatic preparation of medicinal glycosides (such as Robustaside B (HY-N2720), 6-O-caffeoyl salidroside) [1] .
|
-
- HY-111206
-
-
- HY-N9258
-
|
|
Others
|
Others
|
|
p-Vinylphenyl O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside is a phenolic glycoside that can be isolated from the leaves of Viburnum furcatum [1].
|
-
- HY-P2046
-
|
|
Opioid Receptor
|
Neurological Disease
|
|
β-Endorphin (rat) is an endogenous opioid neuropeptide and peptide hormone. β-Endorphin (rat) has analgesic activity and also contributes to food intake in satiated rats. β-Endorphin (rat) can be used in the research of neurological diseases such as analgesia and drug addiction [1] .
|
-
- HY-114392R
-
|
|
FXR
Autophagy
|
Metabolic Disease
|
|
Gly-β-MCA (Standard) is the analytical standard of Gly-β-MCA. This product is intended for research and analytical applications. Gly-β-MCA, a bile acid, is a potent, sable, intestine-selective and oral bioactive farnesoid X receptor (FXR) inhibitor that may be a candidate for the treatment of metabolic disorders[1].
|
-
- HY-157161
-
|
|
11β-HSD
|
Cancer
|
|
11β-HSD2-IN-1 (compound CDSN) is a potent inhibitor of 11β-HSD2, inhibiting the metabolism of Cholestane-3β,5α,6β-triol (CT) in cells by 11β-HSD2 into the tumor promoter, carcinosterone. 11β-HSD2-IN-1 inhibits testosterone biosynthesis, thereby inhibiting MCF-7 cell proliferation. 11β-HSD2-IN-1 has immune activity and antiviral infection effects [1].
|
-
- HY-125135
-
|
β-Peltatin
|
Drug Isomer
|
Cancer
|
|
(-)-β-Peltatin is an organic heterotetracyclic compound with antitumor activity and phytometabolite effects that are functionally related to α-peltatin [1].
|
-
- HY-P4892
-
-
- HY-P4887
-
-
- HY-P4894
-
-
- HY-P4883
-
-
- HY-P4884
-
-
- HY-W011410
-
|
p-Nitrophenyl β-D-Mannopyranoside
|
Glycosidase
|
Others
|
|
4-Nitrophenyl β-D-mannopyranoside is a useful substrate for β-D-mannopyranosidase. 4-Nitrophenyl β-D-mannopyranoside is also a substrate for GH1-glucosidase (EaBgl1A) and α-L-rhamnosidase [1] .
|
-
- HY-168079
-
|
|
GSK-3
Tau Protein
|
Neurological Disease
Inflammation/Immunology
|
|
GSK-3β inhibitor 21 (compound 44) is an ATP-competitive GSK-3β inhibitor (IC50=6.06 μM) with anti-amyloid aggregation and tau phosphorylation inhibitory activities. GSK-3β inhibitor 21 can be used in the study of Alzheimer's disease [1].
|
-
- HY-161458
-
|
|
GSK-3
Tau Protein
|
Neurological Disease
|
|
GSK-3β inhibitor 16 (compound 7c) is a GSK-3β inhibitor with the IC50 of 4.68 nM. GSK-3β inhibitor 16 decreases Tau hyperphosphorylated aggregate and alleviates cognitive impairments in the Scopolamin (HY-N0296)-induced model in mice [1].
|
-
- HY-133179
-
-
- HY-P1517
-
-
- HY-P1850
-
-
- HY-P1510
-
-
- HY-151892S
-
-
- HY-N13402
-
|
|
Others
|
Others
|
|
Formononetin-8-C-beta-D-apiofuranosyl-(1->6)-O-beta-D-glucopyranoside is a natural product [1].
|
-
- HY-N2703
-
|
|
Glycosidase
|
Metabolic Disease
|
|
6β-Hydroxyipolamiide can be isolated from the methanolic extract of S. jamaicensis leaves. 6β-Hydroxyipolamiide has α-glucosidase inhibitory activity with an IC50 of 539.17 μg/mL [1].
|
-
- HY-N6740
-
|
|
Apoptosis
|
Metabolic Disease
|
|
Beta-Zearalenol is an mycotoxin produced by Fusarium spp, which causes apoptosis and oxidative stress in mammalian reproductive cells [1]. Beta-Zearalenol is the derivative of zearalenone (ZEA) which can conjugate with glucuronic acid .
|
-
- HY-119963A
-
|
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
trans-β-terpineol, a monoterpenoid compound, can be isolated from the leaves of Schinus terebinthifolius. Terpineol has antioxidant and antibacterial activity. trans-β-terpineol is a bioactive compound that plays an antibacterial role in Schinus terebinthifolius [1].
|
-
- HY-N10013
-
|
|
Insecticide
|
Others
|
|
β-Damascone is an aroma active rice volatile and is widely used in perfume compositions. β-Damascone has also received certain attention as a potential cancer chemopreventive and a mosquito and muscoid insecticide [1] .
|
-
- HY-122482
-
-
- HY-N7635
-
|
β-D-Glucopyranosyl oleanolate
|
NO Synthase
COX
Interleukin Related
Claudin
p38 MAPK
Akt
PI3K
|
Inflammation/Immunology
|
|
Oleanolic acid 28-O-β-D-glucopyranoside (β-D-Glucopyranosyl oleanolate) is an orally active pentacyclic triterpenoid compound. Oleanolic acid 28-O-β-D-glucopyranoside has anti-inflammatory effects. In ulcerative colitis models, Oleanolic acid 28-O-β-D-glucopyranoside can inhibit the inflammatory response, enhance the intestinal epithelial barrier function, and modulate the gut microbiota. Its mechanism of action is related to the PI3K-AKT and MAPK signaling pathways. Oleanolic acid 28-O-β-D-glucopyranoside can be used in the research of diseases such as colitis [1] .
|
-
- HY-N2168
-
|
(+)-Pinoresinol 4-O-β-D-glucopyranoside
|
Glycosidase
Estrogen Receptor/ERR
Phosphodiesterase (PDE)
|
Neurological Disease
Metabolic Disease
Cancer
|
|
Pinoresinol 4-O-β-D-glucopyranoside ((+)-Pinoresinol 4-O-β-D-glucopyranoside) is an orally active α-glucosidase inhibitor, with an IC50 of 48.13 μg/mL. Pinoresinol 4-O-β-D-glucopyranoside binds to estrogen receptors. Pinoresinol 4-O-β-D-glucopyranoside inhibits phosphodiesterase. Pinoresinol 4-O-β-D-glucopyranoside exhibits various activities such as antioxidant, anti-inflammatory, anti-hyperglycemic, hepatoprotective and anti-epileptic effects [1] .
|
-
- HY-N14860
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Milbemycin β3 is a macrolide antibiotic. Milbemycin β3 has insecticidal effects on agricultural harmful insects, pans, larvae, etc [1].
|
-
- HY-E70393A
-
|
|
Others
|
Metabolic Disease
|
|
Human Factor IXa Beta is composed of two polypeptide chains held together by disulfide bonds. Human Factor IXa Beta shows clotting activity [1].
|
-
- HY-N14900
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Milbemycin β1 is a macrolide antibiotic. Milbemycin β1 has insecticidal effects on agricultural harmful insects, pans, larvae, etc [1].
|
-
- HY-139751
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
β-Lactamase-IN-4 is a β-lactamase inhibitor extracted from patent WO2013149121A1, compound 708. β-Lactamase-IN-4 can be used for the research of bacterial infections [1].
|
-
- HY-146075
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
β-Lactamase-IN-8 (compound 20) is a potent and oral bioavailable broad-spectrum cyclic boronate β-lactamase inhibitor. β-Lactamase-IN-8 can be used for researching antibacteria [1].
|
-
- HY-139779
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
β-Lactamase-IN-5 is a β-lactamase inhibitor extracted from patent WO2013149121A1, compound 720. β-Lactamase-IN-5 can be used for the research of bacterial infections [1].
|
-
- HY-N8279
-
|
Endo-β-1,3-1,4-glucanase
|
Endogenous Metabolite
|
Metabolic Disease
|
|
β-1,3-1,4-Glucanase catalyzes the hydrolysis ofβ-glucan into low molecular weight glucose polymers, thus reducing the hydrophilicity and viscosity of chyme and eliminating the anti-nutritional negative effect. β-1,3-1,4-glucanase can improve feed intake, enhance animal production, regulate cecal microbiota and increase feed conversion ratio [1].
|
-
- HY-163339
-
|
|
Beta-lactamase
|
Infection
|
|
Metallo-β-lactamase-IN-14 (Compound 17e) is a Metallo-β-Lactamase inhibitor. Metallo-β-lactamase-IN-14 shows inhibition activity against VIM-1 and VIM-2. Metallo-β-lactamase-IN-14 has antibacterial activity against Gram-negative (GN) bacteria and P. aeruginosa [1].
|
-
- HY-151166
-
|
|
β-glucuronidase
Bacterial
|
Cancer
|
|
β-Glucuronidase-IN-2 is a potent E. coli β-glucuronidase inhibitor with an IC50 value of 0.24 μM, an Ki value of 1.09 μM. β-Glucuronidase-IN-2 shows antiproliferative activity. β-Glucuronidase-IN-2 has the potential for the research of anti-cancer and anti-inflammatory therapies [1].
|
-
- HY-N6740S
-
|
|
Isotope-Labeled Compounds
Apoptosis
|
Metabolic Disease
|
|
β-Zearalanol-d4 is a deuterium labeled Beta-Zearalanol (HY-N6740） [1]. Beta-Zearalenol is an mycotoxin produced by Fusarium spp, which causes apoptosis and oxidative stress in mammalian reproductive cells . Beta-Zearalenol is the derivative of zearalenone (ZEA) which can conjugate with glucuronic acid .
|
-
- HY-N0171
-
|
|
Apoptosis
Endogenous Metabolite
|
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
|
Beta-Sitosterol (purity>80%) includes β-sitosterol (≥80%), stigmasterol, campesterol and brassicasterol mainly. Beta-Sitosterol is a plant sterol. Beta-Sitosterol (purity>80%) interfere with multiple cell signaling pathways, including cell cycle, apoptosis, proliferation, survival, invasion, angiogenesis, metastasis and inflammation [1].
|
-
- HY-W024698
-
|
|
Others
|
Others
|
|
β-Cyclogeraniol is a natural odour compound [1].
|
-
- HY-113418
-
-
- HY-N7276A
-
|
|
Others
|
Others
|
|
7β-Galloyloxysweroside is a natural product [1].
|
-
- HY-P10035
-
|
|
Amyloid-β
|
Neurological Disease
|
|
β Amyloid(28-35) human is a β-amyloid peptide (Abeta), a lipid-induced amyloid core fragment. β Amyloid oligomers are neurotoxic, and β Amyloid(28-35) human can interact with neuronal membranes, regulate secondary structure and neurotoxicity, and cause Alzheimer's disease. β Amyloid(28-35) human has anisotropic effects on the acidic phospholipid DPH, resulting in enhanced internal fluidity of lipid membrane bilayers [1].
|
-
- HY-P3004
-
|
Lyticase
|
Endogenous Metabolite
|
Others
|
|
Endo-1,3-β-glucanase specifically hydrolyzes β-1,3-glycosidic bonds randomly along the β-glucan chain, and the final product is mainly glucan oligosaccharide. Endo-1,3-β-glucanase is produced by a variety of fungi, is often used in biochemical studies [1].
|
-
- HY-N13555
-
|
|
Others
|
Others
|
|
(19R)-5β,19-Epoxy-19-methoxycucurbita-6,23-diene-3β,25-diol is a triterpenoid product that can be isolated from Momordica charantia [1].
|
-
- HY-156243
-
|
|
ROCK
|
Cancer
|
|
GDI2-IN-1 (compound (+)-37) is a GDP-dissociation inhibitor beta (GDI2) inhibitor with an IC50 of 2.87 μM and a KD of 36 μM. GDI2-IN-1 exhibits excellent in vivo antitumor activity in GDI2-overexpressing pancreatic xenograft models [1].
|
-
- HY-N1501
-
|
|
α-synuclein
|
Cardiovascular Disease
Neurological Disease
Inflammation/Immunology
|
|
Beta-asarone is an orally active and BBB-penetrable anti-inflammatory agent and neuroprotective agent, which is the major ingredient of Acorus tatarinowii Schott. Beta-asarone can protect nerve cells from apoptosis and autophagy, inhibit expression of α-synuclein, as well as myocardial protection. Beta-asarone can be used in the study of neurological and cardiovascular diseases [1] .
|
-
- HY-131108
-
|
L-β-Aspartyl-L-aspartic acid
|
Others
|
Others
|
|
β-Aspartylaspartic acid is a natural compound found in Asparagus (Asparagus officinalis) Shoots [1].
|
-
- HY-P1378
-
|
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (1-43)(human) is more prone to aggregation and has higher toxic properties than the long-known Aβ1-42. β-Amyloid (1-43)(human) shows a correlation with both sAPPα and sAPPβ. β-Amyloid (1-43)(human) could be considered an added Alzheimer's disease (AD) biomarker together with the others already in use [1].
|
-
- HY-N8982
-
|
|
Others
|
Others
|
|
Heraclenol 3'-O-[beta-D-apiofuranosyl-(1-6)-beta-D-glucopyranoside] is a Coumarins product that can be isolated from the roots of Heracleum stenopterum [1].
|
-
![Heraclenol 3'-O-[beta-D-apiofuranosyl-(1-6)-beta-D-glucopyranoside]](//file.medchemexpress.com/product_pic/hy-n8982.gif)
- HY-N7945
-
|
|
Others
|
Inflammation/Immunology
|
|
6-Hydroxykaempferol 3-O-β-rutinoside-6-O-β-D-glucoside is a potent antioxidant that can be isolated from Carthamus tinctorius [1].
|
-
- HY-N5119
-
|
|
Others
|
Others
|
|
Kaempferol-3-O-(2''-O-β-D-glucopyl)-β-D-rutinoside is a natural glycoside that could be found in Camellia oleifera seeds [1].
|
-
- HY-126144A
-
|
|
GSK-3
|
Metabolic Disease
|
|
(E/Z)-GSK-3β inhibitor 1 is a racemic compound of (E)-GSK-3β inhibitor 1 and (Z)-GSK-3β inhibitor 1 isomers. GSK-3β inhibitor 1 (compound 3a) is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy, with an IC50 of 4.9 nM [1].
|
-
- HY-N9802
-
|
|
Apoptosis
Bcl-2 Family
|
Cancer
|
|
n-Butyl-β-D-fructofuranoside could be isolated from kangaisan. n-Butyl-β-D-fructofuranoside induces apoptosis through the mitochondrial pathway. n-Butyl-β-D-fructofuranoside can be used for cancer research [1].
|
-
- HY-147651
-
|
|
β-catenin
CDK
c-Myc
|
Cancer
|
|
β-catenin-IN-4 (Compound 39) is a β-catenin inhibitor with a Ki of 0.64 μM. β-catenin-IN-4 reduces the protein expression levels of cyclin D1 and c-Myc [1].
|
-
- HY-N6616
-
|
Pinocembrin-7-O-β-D-glucoside
|
Others
|
Others
|
|
Pinocembrin-7-O-β-D-glucopyranoside (Pinocembrin 7-O-β-D-Glucoside) is is a flavanone that enhances lipid peroxidation [1].
|
-
- HY-P2549
-
-
- HY-P1053
-
-
- HY-126548
-
-
- HY-W345102
-
-
- HY-150537
-
|
|
Cholinesterase (ChE)
GSK-3
Microtubule/Tubulin
ROS Kinase
|
Neurological Disease
|
|
AChE/GSK-3β-IN-1 (compound GT15) is a potent, dual AChE/GSK-3β inhibitor with IC50 values of 1.2, 149.8 and 22.4 nM for hAChE , hBChE and hGSK-3β, respectively. AChE/GSK-3β-IN-1 penetrates the blood-brain barrier (BBB). AChE/GSK-3β-IN-1 has high kinase selectivity profiles for the CMGC kinase family. AChE/GSK-3β-IN-1 occupies the ATP binding site of DYRK1A. AChE/GSK-3β-IN-1 inhibits ROS expression and reduces oxidative stress. AChE/GSK-3β-IN-1 can be used for Alzheimer’s disease research [1].
|
-
- HY-N9439
-
|
|
Endogenous Metabolite
|
Others
|
|
6-O-β-D-Galactopyranosyl-D-galactose, a disaccharide, is a part of the polysaccharide main chain with β-(1→6)-glycoside bonds with a side chain bonded to the main one by the β-(1→3) bond [1].
|
-
- HY-B1449
-
-
- HY-W357142
-
-
- HY-P1850A
-
|
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (1-20) acetate is the acetate form of β-Amyloid (1-20)，which consists of amino acids 1 to 20 of beta amyloid protein [1].
|
-
- HY-P5308
-
|
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (1-19) (acetate) is the acetate form of β-Amyloid (1-19)，which consists of amino acids 1 to 19 of beta amyloid protein [1].
|
-
- HY-114464S1
-
|
4-Androsten-11β-ol-3,17-dione-d7
|
Endogenous Metabolite
11β-HSD
|
Others
|
|
11-Beta-hydroxyandrostenedione-d7 is the deuterium labeled 11-Beta-hydroxyandrostenedione. 11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor [1][2]
|
-
- HY-114464S
-
|
4-Androsten-11β-ol-3,17-dione-d4
|
Isotope-Labeled Compounds
Endogenous Metabolite
11β-HSD
|
Endocrinology
|
|
11-Beta-hydroxyandrostenedione-d4 is the deuterium labeled 11-Beta-hydroxyandrostenedione. 11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor[1][2].
|
-
- HY-N1415
-
-
- HY-W127641R
-
|
|
Biochemical Assay Reagents
|
Others
|
|
β-Methylcholine (chloride) (Standard) is the analytical standard of β-Methylcholine (chloride). This product is intended for research and analytical applications. β-Methylcholine chloride is an organic compound containing choline and chloride ions. It is commonly used as a pharmacological research tool, especially in the study of acetylcholine receptors and signaling pathways. β-Methylcholine chloride has various applications in the pharmaceutical industry, especially as a standard reference material for the calibration of analytical instruments. In addition, it can be used in the production of other choline derivatives and as a precursor of neurotransmitters.
|
-
- HY-123712
-
-
- HY-N10645
-
|
|
Others
|
Others
|
|
Rhamnocitrin 3-O-β-D-apiofuranosyl(1→2)-β-D-glucopyranoside is a flavonol O-glycoside, isolated from Astragali semen of leguminous plants [1].
|
-
- HY-P3777
-
|
|
Potassium Channel
|
Neurological Disease
|
|
β-Bag cell peptide is a neuroactive peptide. β-Bag cell peptide elevates cyclic AMP levels in the bag cell neurons. β-Bag cell peptide decreases the amplitudes of the voltage-dependent potassium currents [1].
|
-
- HY-137261
-
|
|
Others
|
Metabolic Disease
|
|
UDP-β-D-glucose disodium is a the stereoisomer of UDP-α-D-glucose. UDP-β-D-glucose disodium is an oligosaccharide that can be used to synthesize glycoproteins and glycolipids. UDP-β-D-glucose disodium can be used as a substrate [1].
|
-
- HY-P990078
-
|
LY3372993
|
Amyloid-β
|
Neurological Disease
|
|
Remternetug is a human immunoglobulin G1-kappa, anti-APP (amyloid beta A4 precursor protein) Aβ42 N3pGlu peptide monoclonal antibody. Remternetug recognizes a pyroglutamated form of Aβ. Remternetug results in rapid and robust amyloid plaque reduction. Remternetug can be used for Alzheimer's disease research [1] .
|
-
- HY-W145656S
-
-
- HY-P3860
-
-
- HY-169126
-
|
|
β-catenin
Wnt
|
Cancer
|
|
β-catenin modulator IIa-661 is a β-catenin modulator that modulates β-catenin activity and inhibits the activity of the Wnt/wingless (wg) signaling pathway. β-catenin modulator IIa-661 can be utilized in cancer research [1].
|
-
- HY-W145553
-
|
|
Biochemical Assay Reagents
|
Others
|
|
GalNAcβ(1-3)GlcNAc-β-pNP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-P1779
-
-
- HY-168500
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
Metallo-β-lactamase-IN-16 (compound 18) is a sulfone containing metallo-β-lactamase inhibitor with an anti-bacterial activity. Metallo-β-lactamase-IN-16 inhibits NDM-1 (New Dehli metallo-β-lactamase-1), IMP-1 (imipenemase-1), VIM-1 (Verona integron-encoded metallo-β-lactamase), and VIM-2 with IC50 values of 0.16 nM, 0.23 nM, 0.31 nM and 1.0 nM, respectively [1].
|
-
- HY-150693
-
|
|
Estrogen Receptor/ERR
|
Cancer
|
|
Estrogen receptor β antagonist 2 is a potent and selective estrogen receptor β (ERβ) antagonist with IC50s of 109.10, 0.63 µM for Erα and Erβ, respectively [1].
|
-
- HY-169606
-
-
- HY-124265S
-
-
- HY-P4740
-
-
- HY-N4034
-
|
|
Others
|
Others
|
|
Hopane-3β,22-diol (compound 74) is a hopane isolated from A. mariesii [1].
|
-
- HY-W751152
-
|
|
GABA Receptor
|
Cancer
|
|
α,β-Thujone is a component of the essential oils of some plants. α,β-Thujone causes cancers in male rats and induces seizures in the highest doses [1].
|
-
- HY-W441968
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
L-threo-β-Hydroxyaspartic acid is an amino acid antibiotic. L-threo-β-Hydroxyaspartic acid has the activity of inhibiting Bacillus subtilis, Xanthomonas oryzae, Mycobacterium phlei and Botrytis cinerea [1].
|
-
- HY-14156
-
|
|
11β-HSD
|
Metabolic Disease
|
|
11β-HSD1-IN-15 is an inhibitor of 11β-hydroxysteroid dehydrogenase type I (11β-HSD1). 11β-HSD1-IN-15 blocks the conversion of corticosterone to cortisol by binding to the active site of the 11β-HSD1 enzyme. 11β-HSD1-IN-15 can be used to investigate the role of 11β-HSD1 enzymes IN the development of metabolic syndrome, obesity, cognitive decline and type 2 diabetes [1].
|
-
- HY-118161
-
|
beta-1-Adamantylaspartic acid
|
Biochemical Assay Reagents
|
Others
|
|
1-Adamantylaspartate is a newly developed β-β-1-imidopropionic acid used to synthesize the C-terminal octapeptide of the β subunit of human chorionic gonadotropin (hCG) and the hexadecapeptide of the α subunit of the insulin receptor (30-55) by conventional solution methods and solid phase methods, aiming to inhibit the formation of asparagine during the synthesis of asparagyl peptides. Studies have shown that β-β-1-imidopropionic acid is an effective protector of the β-carboxyl function of aspartic acid residues.
|
-
- HY-170491
-
|
|
GSK-3
|
Infection
Neurological Disease
|
|
GSK-3β inhibitor 23 (Compound 11726169) is the inhibitor for glycogen synthase kinase-3, that inhibits GSK-3β and GSK-3α with IC50 of 12.1 nM and 18.8 nM. GSK-3β inhibitor 23 exhibits antiviral activity against HIV 1. GSK-3β inhibitor 23 exhibits good metabolic stablility in mouse/human liver microsomes and plasma, but poor Caco-2 permeability (which predicts low oral bioavailability) [1].
|
-
- HY-N2075R
-
|
|
Others
|
Inflammation/Immunology
|
|
3-Acetyl-beta-boswellic acid (Standard) is the analytical standard of 3-Acetyl-beta-boswellic acid. This product is intended for research and analytical applications. 3-Acetyl-beta-boswellic acid is a boswellic acid isolated from Boswellia serrata gum resin [1].
|
-
- HY-P2869D
-
|
|
Others
|
Metabolic Disease
|
|
β1-3,6 Galactosidase, Xanthomonas manihotis is a highly specific exoglycosidase that catalyzes the hydrolysis of non-reducing terminal β1-3 and β1-6 linked galactose from complex carbohydrates and glycoproteins [1].
|
-
- HY-115543
-
|
|
Wnt
β-catenin
|
Cancer
|
|
β-catenin-IN-37 is a selective β-Catenin/T-cell factor protein-protein interaction (β-catenin/Tcf PPI) inhibitor. β-catenin-IN-37 inhibits canonical Wnt signaling and the growth of colorectal cancer cells SW480 and HCT116 with the IC50 values of 20 μM and 31 μM, respectively [1].
|
-
- HY-144261
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
Metallo-β-lactamase-IN-3 (compound 35) is a potent metallo-β-lactamases (MBL) inhibitor. Metallo-β-lactamase-IN-3 shows high activity against VIM-1 and NDM-1, with IC50 of 0.6 and 1.0 μM, respectively. Metallo-β-lactamase-IN-3 does not show inhibition of IMP-7 [1].
|
-
- HY-P3841
-
|
|
PKC
|
Others
|
|
Protein Kinase C β Peptide is a peptide fragment of Protein Kinase Cβ. Protein Kinase Cβ is related with hyperglycemia decreases endothelium-derived nitric oxide. Inhibition of Protein kinase Cβ prevents the reduction in endothelium-dependent vasodilation induced by acute hyperglycemia [1].
|
-
- HY-N0181A
-
|
9β,10α-Ergosterol
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Lumisterol (9β,10α-Ergosterol), a steroid compound, is the (9β,10α)-stereoisomer of Ergosterol (HY-N0181). Lumisterol is a photoprotective agent against UVB-induced DNA damage and anti-proliferative activities [1].
|
-
- HY-N12035
-
|
|
Others
|
Cancer
|
|
Picropodophyllin-4-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside (compound 17) is a lignan isolated from the roots and rhizomes of Podophyllum sinensis [1].
|
-
- HY-N9981
-
|
|
Biochemical Assay Reagents
|
Cancer
|
|
5β-Hydroxybufotalin (compound 6) is an anticancer agent that can effectively inhibit the growth activity of cancer cells. 5β-Hydroxybufotalin is also a natural product obtained from the chinese traditional drug Ch'an Su [1].
|
-
- HY-104076
-
-
- HY-P3550
-
-
- HY-N13420
-
|
|
Others
|
Others
|
|
3beta-Acetoxy-11alpha,12alpha-epoxyoleanan-28,13beta-olide is a natural product [1].
|
-
- HY-Y1801
-
|
L-Aspartic acid β-methyl ester hydrochloride
|
Amino Acid Derivatives
|
Others
|
|
β-Methyl L-aspartate hydrochloride is an aspartic acid derivative [1].
|
-
- HY-124265S2
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
4β-Hydroxycholesterol-d4 is the deuterium labeled 4β-Hydroxycholesterol. 4β-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation[1][2].
|
-
- HY-160709
-
|
|
Wnt
β-catenin
|
Cancer
|
|
Wnt/β-catenin-IN-2 (Compound 3235-0367) is a Wnt/β-catenin signaling pathway inhibitor, with IC50 and KD values of 7.1 and 2.5 μM, respectively. Wnt/β-catenin-IN-2 can be used for the research of cancer [1].
|
-
- HY-P3185
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
beta-Galactose dehydrogenase can make conversion of galactose to galactonolactone and the concomitant reduction of NAD to the fluorescent NADH. beta-Galactose dehydrogenase can be used for the determination of galactose [1].
|
-
- HY-Y1750A
-
-
- HY-Y1750
-
-
- HY-W011063
-
|
|
Cathepsin
|
Metabolic Disease
|
|
Gly-Phe-β-naphthylamide is the substrate of Cathepsin C. Gly-Phe-β-naphthylamide can be used to study intralysosomal hydrolysis, lysosomal membrane permeability, and the function of cathepsin C [1].
|
-
- HY-N9169
-
|
|
Others
|
Others
|
|
8β-(4-Hydroxytigloyloxy)ovatifolin is a Sesquiterpenoids product that can be isolated from the herbs of Eupatorium glehni [1].
|
-
- HY-P4867
-
|
|
Amyloid-β
|
Others
|
|
β Amyloid (1-42) (scrambled) is acontrol of β-Amyloid (1-42), human TFA (HY-P1363).
|
-
- HY-169569
-
|
|
β-catenin
|
Cancer
|
|
β-Catenin modulator-8 (Compound Ⅸa) is a β-Catenin modulator and can be used for cancer research [1].
|
-
- HY-153678
-
|
|
β-catenin
|
Cancer
|
|
β-Catenin modulator-1 (IIa-650) is a β-Catenin modulator useful in cancer research [1].
|
-
- HY-138943
-
|
5'-O-β-D-galactosyl-5-fluorouridine
|
Drug Intermediate
|
Cancer
|
|
5-Fluorouridine 5'-O-β-D-galactopyranoside (5'-O-β-D-galactosyl-5-fluorouridine) is a 5-Fluorouridine proagent. 5-Fluorouridine 5'-O-β-D-galactopyranoside can be converted by the enzyme β-D-galactosidase to the potent antineoplastic agent 5-Fluorouridine [1].
|
-
- HY-130214
-
-
- HY-E70046
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
beta-1,4-Galactosyltransferase (LgtB) (EC 2.4.1.90) (B4GALT1 (LgtB)) is often used in biochemical studies. beta-1,4-Galactosyltransferase (LgtB) catalyzes the reaction involving UDP-galactose and N-acetylglucosamine for the production of galactose beta-1,4-N-acetylglucosamine [1].
|
-
- HY-P2869B
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
β1-4 Galactosidase, E. coli is a highly specific exoglycosidase that catalyzes the hydrolysis of terminal, non-reducing β1-4 linked galactose residues from oligosaccharides [1].
|
-
- HY-W043333
-
-
- HY-N0338
-
|
|
Others
|
Others
|
|
(-)-Syringaresnol-4-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside is a lignan glycoside that can be isolated from the stem bark of Albizia julibrissin Durazz [1].
|
-
- HY-U00325
-
|
|
11β-HSD
|
Neurological Disease
|
|
11β-HSD1-IN-1 is an inhibitor of 11β-hydroxydehydrogenase 1 (11β-HSD1), with an IC50 of 52 nM, and used for the treatment of pain.
|
-
- HY-137550
-
|
|
Biochemical Assay Reagents
|
Others
|
|
4-Nitrophenyl β-D-galactopyranoside is a derivative of beta-D-galactoside and monosaccharide. 4-Nitrophenyl β-D-galactopyranoside can be used for affinity label [1].
|
-
- HY-N2923
-
-
- HY-101532
-
|
β-CDN3; 6A-deoxy-6A-azido-β-cyclodextrin
|
Biochemical Assay Reagents
|
Others
|
|
6A-Azido-6A-deoxy-β-cyclodextrin (β-CDN3; 6A-deoxy-6A-azido-β-cyclodextrin) is a new water-soluble Schiff base ligand based on β-cyclodextrin (HY-107201). 6a-Azido-6a-deoxy-β-cyclodextrin can be used for biaqueous hydroformylation. β-cyclodextrin (βCD) has a unique affinity for Dexamethasone (HY-14648), and can be used as a topical osmotic enhancer to introduce it into the agent carrier system [1] . 6A-Azido-6A-deoxy-β-cyclodextrin is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-D1510
-
|
|
Biochemical Assay Reagents
|
Others
|
|
4-Nitrophenyl 2-O-(β-L-Fucopyranosyl)-β-D-Galactopyranoside is a synthetic chromogenic substrate and can be used in the assay of α-fucosidases which hydrolyze the glycosidic linkage Fuc α1-2Gal. The assay is based on the sequential action of α-fucosidase and an exogenously added exo-β-d-galactosidase to release the easily measurable p-nitrophenol moiety [1].
|
-
- HY-15927
-
|
|
Biochemical Assay Reagents
|
Metabolic Disease
|
|
4-Nitrophenyl β-D-glucopyranoside is a chromogenic substrate for β-glucosidase. 4-Nitrophenyl β-D-glucopyranoside is converted to a colored product, p-nitrophenol that is easily detected spectrophotometrically at 405 nm when used in a β-glycosidase assay. 4-Nitrophenyl β-D-glucopyranoside is hydrolysed through intramolecular nucleophilic catalysis by the phosphate group in the 2-position. 4-Nitrophenyl β-D-glucopyranoside is promising for research of postmenopausal osteoporosis [1] .
|
-
- HY-W011792R
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Diacetone-β-D-fructose (Standard) is the analytical standard of Diacetone-β-D-fructose. This product is intended for research and analytical applications. Diacetone-β-D-fructose is a biochemical reagent that can be used as a biological material or organic compound for life science related research [1].
|
-
- HY-115419
-
|
|
Liposome
|
Others
|
|
1-Thio-β-D-glucose sodium is the sodium salt form of 1-Thio-β-D-glucose. 1-Thio-β-D-glucose forms hydrophilic self-assembled monolayer with metal, stablizes the lipid bilayer and protects the proteins from denaturation [1].
|
-
- HY-N2513
-
|
|
Lipoxygenase
DNA/RNA Synthesis
|
Cancer
|
|
β-Boswellic acid is isolated from the gum resin of Boswellia serrata with anticancer, antioxidant activity, anti-inflammatory activity and anti-arthritic pain.β-Boswellic acid is an orally active nonreducing-type inhibitor of the 5-lipoxygenase (5-LO) product formation either interacting directly with the 5-LO or blocking its translocation. β-Boswellic acid inhibits the synthesis of DNA, RNA and protein in human leukemia HL-60 cells with IC50 values ranging from 0.6 to 7.1 μM. β-Boswellic acid is promising for research of diabetes, inflammatory and arthritic diseases [1] .
|
-
- HY-P1286
-
-
- HY-W141960
-
-
- HY-113482S
-
-
- HY-W587978
-
-
- HY-173397
-
|
|
β-glucuronidase
Bacterial
|
Metabolic Disease
|
|
β-Glucuronidase-IN-3 (Compound 49) is a covalent allosteric β-glucuronidase inhibitor. β-Glucuronidase-IN-3 has potent inhibitory activity against Escherichia coli β-glucuronidase (EcGUS) (IC50: 12.9 nM). β-Glucuronidase-IN-3 exerts its inhibitory effect by reversibly covalently modifying the cysteine residues (Cys28, Cys443, and Cys197) of EcGUS. β-Glucuronidase-IN-3 can be used in the study of intestinal microbiota-related diseases, especially to alleviate the toxic side effects of Irinotecan (HY-16562) and nonsteroidal anti-inflammatory drugs (NSAIDs) [1].
|
-
- HY-E70078
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Cystathionine β-synthase is an enzyme that catalyzes the condensation of serine and homocysteine to water and cystathionine. Cystathionine β-synthase is a prominent enzyme for the production of hydrogen sulfide (H2S) [1].
|
-
- HY-152805
-
|
|
Nucleoside Antimetabolite/Analog
|
Others
|
|
9-(2-β-C-Methyl-β-D-ribofuranosyl)purine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc [1].
|
-
- HY-N15000
-
|
|
Bacterial
|
Infection
|
|
Lipomycin β has the activity of anti-Gram-positive bacterial and no activity against fungi (including yeast) [1].
|
-
- HY-169472
-
|
|
Drug Derivative
|
Cardiovascular Disease
|
|
11-Deoxy prostaglandin F1β is a synthetic analog of PGF1β. 11-Deoxy prostaglandin F1β exhibits vasodepressor and bronchodilator activities in guinea pigs [1].
|
-
- HY-138244
-
-
- HY-N5152
-
|
|
Others
|
Cancer
|
(2′S)-4′-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranosylvisamminol is a chromone Glycoside that could be isolated from Roots of Saposhnikovia divaricate. (2′S)-4′-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranosylvisamminol exhibits weak anti-cancer activity in human cancer cell lines [1].
|
-
- HY-W283359
-
|
|
Fluorescent Dye
|
Others
|
|
4-Methylumbelliferyl β-D-ribofuranoside is a fluorogenic substrate of β-ribosidase [1].
|
-
- HY-147055
-
-
- HY-D0935
-
|
|
β-glucuronidase
Fluorescent Dye
|
Others
|
|
4-Methylumbelliferyl-β-D-glucuronide is a fluorogenic substrat (λex=362 nm, λem=445 nm). 4-Methylumbelliferyl-β-D-glucuronide has potential applications in detecting the activity of β-glucuronidase and the number of Escherichia coli [1] .
|
-
- HY-P1362A
-
|
Amyloid β Peptide (42-1)(human) TFA
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (42-1), human TFA is the inactive form of Amyloid β Peptide (1-42). β-Amyloid (42-1), human TFA is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease [1].
|
-
- HY-116055
-
|
3-O-β-D-Galactopyranosyl-sn-glycerol
|
Biochemical Assay Reagents
|
Others
|
|
(2R)-Glycerol-O-β-D-galactopyranoside (3-O-β-D-Galactopyranosyl-sn-glycerol) is a good substrate for all three components of the lac operon, i.e. β-galactosidase, the lactose transporter and thiogalactoside transacetylase [1].
|
-
- HY-155504
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
Metallo-β-lactamase-IN-11 (compound 5f) is a Metallo-β-lactamases (MBLs) inhibitor, potent against bacterial metallophyllactamase CphA (IC50=45 µM). Metallo-β-lactamase-IN-11 (10 µM) inhibits NDM-1 by 49% and AIM-1 by 61%. Metallo-β-lactamase-IN-11 can be used in the research of inhibiting antibiotic resistance [1].
|
-
- HY-145381
-
|
|
11β-HSD
|
Metabolic Disease
|
|
11β-HSD1-IN-6 is a an 11β-HSD-1 inhibitor. The 11β hydroxysteroid dehydrogenase enzymes (11β-HSDs) mediate the interconversion of the glucocorticoid (GC) corticosterone or cortisol to an inactive form, 11-dehydrocorticosterone (11-DHC) or Cortisone, respectively [1].
|
-
- HY-W129359
-
|
|
11β-HSD
|
Neurological Disease
Metabolic Disease
|
|
11β-HSD1-IN-8 (compound c6a) is a 11β HSD1 inhibitor with an IC50 value of 2.3 μM for human 11β HSD1. 11β-HSD1-IN-8 can be used for the research of diabetes and cognitive decline [1].
|
-
- HY-W106057
-
|
|
11β-HSD
|
Neurological Disease
Metabolic Disease
|
|
11β-HSD1-IN-7 (compound c10a) is a 11β HSD1 inhibitor with an IC50 value of 1.9 μM for human 11β HSD1. 11β-HSD1-IN-7 can be used for the research of diabetes and cognitive decline [1].
|
-
- HY-107201
-
|
betadex
|
Influenza Virus
|
Infection
|
|
β-Cyclodextrin is a cyclic polysaccharide composed of seven units of glucose (α-D-glucopyranose) linked by α-(1,4) type bonds. β-Cyclodextrin has often been used to enhance the solubility of agents. β-Cyclodextrin has anti-influenza virus H1N1 activities.
|
-
- HY-P1468F1
-
|
5-FAM-Amyloid β-protein (1-28)
|
Amyloid-β
|
Others
|
|
5-FAM-β-Amyloid (1-28) is afluorescently labeled β-Amyloid (1-28) (HY-P1468).
|
-
- HY-138795
-
|
|
Endogenous Metabolite
|
Cancer
|
|
Curcumin-β-D-glucuronide is a major metabolite after oral intake of Curcumin in hepatic tissue and portal blood. Curcumin-β-D-glucuronide can be used for the research of colon cancer [1] .
|
-
- HY-144513
-
|
|
Bacterial
|
Infection
|
|
Stigmastan-3β-ol is a sterol that can be isolated from Tinospora sinensis and Ginkgo biloba L.. Stigmastan-3β-ol has antimicrobial activity [1] .
|
-
- HY-124265S1
-
-
- HY-149728
-
-
- HY-W324243
-
|
|
11β-HSD
|
Metabolic Disease
|
|
11β-HSD1-IN-9 (compound c4a) is a potent 11β-HSD1 inhibitor with IC50 values of 0.48 and 1.3 µM for human and murine 11β-HSD1, respectively. 11β-HSD1-IN-9 competitively interacts with rat 11β-HSD1. 11β-HSD1-IN-19 can be used in studies of obesity, hyperglycemia and cognitive impairment [1].
|
-
- HY-161667
-
|
|
GSK-3
HDAC
|
Neurological Disease
|
|
GSK-3β/HDAC-IN-1 (Compd 4) is a brain-penetrant and first in class dual non-ATP-competitive Glycogen Synthase Kinase 3β/Histone Deacetylases (GSK-3β/HDACs) Inhibitor with IC50s of 0.142, 0.03 and 0.045 μM against GSK-3β, HDAC2 and HDAC6, respectively. GSK-3β/HDAC-IN-1 can be used for Alzheimer’s disease research [1].
|
-
- HY-N12095
-
|
|
Others
|
Others
|
|
Chavicol β-D-glucoside is a phenylpropanoid heteroside. Chavicol β-D-glucoside can be isolated from subspecies of Cedronella canariensis [1].
|
-
- HY-W768883
-
-
- HY-N7401
-
|
|
Complement System
|
Others
|
|
Entadamide-A-β-D-glucopyranoside is one of the major components in the seeds of Entada phaseoloides. Entadamide-A-β-D-glucopyranoside has anti-complement activitie [1].
|
-
- HY-P2770
-
|
|
Endogenous Metabolite
|
Others
|
|
β-Amylase, Bacilus subtilis has abundant starch degrading activities. β-Amylase can be used for various biochemical studies [1].
|
-
- HY-P10040
-
|
|
Amyloid-β
|
Neurological Disease
|
|
(Gln22)β-Amyloid (1-40) human is an amyloid beta protein (Aβ)-containing peptide used in Alzheimer's disease research [1].
|
-
- HY-E70113
-
-
- HY-117215A
-
|
|
Others
|
Others
|
|
trans-β-Ocimene is a compound that can be isolated from Melaleuca viridiflora [1].
|
-
- HY-N9751
-
|
|
Others
|
Others
|
|
β-Guaiene is a sesquiterpene, which can be used for perfuming and flavoring [1].
|
-
- HY-153477
-
-
- HY-N0343A
-
|
p-Formylphenyl-β-D-glucopyranoside; p-Hydroxybenzaldehyde glucoside
|
Others
|
Others
|
|
4-Formylpyrnyl-β-D-glucopyranoside (p-Formylphenyl-β-D-glucopyranoside) is a metabolite of Gastrodin (HY-N0115) in rat plasma. 4-Formylpyrnyl-β-D-glucopyranoside can be used to study the effects of multiple doses and food on the pharmacokinetic behavior of oral Gastrodin and its metabolites [1].
|
-
- HY-N11678
-
|
DON-3-β-D-glucoside; Deoxynivalenol 3-glucoside
|
Drug Metabolite
|
Metabolic Disease
|
|
Deoxynivalenol-3-β-D-glucoside (DON-3-β-D-glucoside) is a plant metabolite of the Fusarium mycotoxin Deoxynivalenol (HY-N6684). Deoxynivalenol-3-β-D-glucoside exhibits lower toxicity than Deoxynivalenol in vitro and in vivo [1] .
|
-
- HY-135594
-
|
|
Estrogen Receptor/ERR
|
Metabolic Disease
|
|
4'-Raloxifene-β-D-glucopyranoside, a metabolite of Raloxifene, is a benzothiophene glucuronidated at the 4' postion. 4'-Raloxifene-β-D-glucopyranoside is a selective and orally active estrogen receptor antagonist. 4'-Raloxifene-β-D-glucopyranoside can be used for inhibiting bone loss and resorption, and lowering lipid levels. 4'-Raloxifene-β-D-glucopyranoside, example 5, is extracted from patent US5567820A [1].
|
-
- HY-135595
-
|
|
Estrogen Receptor/ERR
Drug Metabolite
|
Metabolic Disease
|
|
6-Raloxifene-β-D-glucopyranoside, a derivative of Raloxifene, is a benzothiophene glucuronidated at the 6' postion. 6-Raloxifene-β-D-glucopyranoside is a selective and orally active estrogen receptor antagonist. 6-Raloxifene-β-D-glucopyranoside can be used for inhibiting bone loss and resorption, and lowering lipid levels. 6'-Raloxifene-β-D-glucopyranoside, compound Ia, is extracted from patent US5567820A [1].
|
-
- HY-152817
-
|
|
Nucleoside Antimetabolite/Analog
|
Others
|
|
2′-β-C-Methyl-beta-D-6-methylpurine riboside is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc [1].
|
-
- HY-124324
-
|
p-Nitopheyl β-D-cellotioside
|
Fluorescent Dye
|
Others
|
|
4-Nitrophenyl β-D-cellotrioside (p-Nitopheyl β-D-cellotioside) is a chromogenic substrate for endoglucanases and cellulose biohydrolases. As a fluorescent dye, nitrophenyl β-D-Cellotrioside can be hydrolyzed by enzymes to release 4-nitrophenol, producing a yellow color. The activity of the enzyme can be quantitatively analyzed by monitoring the change in absorbance at 405 nm [1].
|
-
- HY-N6851
-
|
Glycyrrhetic acid 3-O-mono-β-D-glucuronide; 3-monoglucuronyl-glycyrrhetinic acid
|
Others
|
Inflammation/Immunology
|
|
Glycyrrhetic acid 3-O-β-D-glucuronide, isolated from glycyrrhiza, is an important derivative of glycyrrhizin (GL) with an anti -allergic activity [1]. Glycyrrhetic acid 3-O-β-D-glucuronide (GAMG) shows that β-glucuronidases (β-GUS) are key GAMG-producing enzymes, displaying a high potential to convert GL directly into GAMG .Glycyrrhetic acid 3-O-β-D-glucuronide is valuable as a sweetener.
|
-
- HY-P1378A
-
|
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (1-43)(human) TFA is more prone to aggregation and has higher toxic properties than the long-known Aβ1-42. β-Amyloid (1-43)(human) TFA shows a correlation with both sAPPα and sAPPβ. β-Amyloid (1-43)(human) TFA could be considered an added Alzheimer's disease (AD) biomarker together with the others already in use [1].
|
-
- HY-136960
-
|
|
Adrenergic Receptor
|
Others
|
|
β2AR antagonist 1 (Cmpd-15PA) is an antagonist of β2 adrenergic receptor (β2AR). β2AR antagonist 1 binds to the intracellular surface of the β2AR [1].
|
-
- HY-160618
-
|
|
11β-HSD
|
Metabolic Disease
|
|
11β-HSD2-IN-2 (compound 3) is a selective inhibitor for 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) with an IC50 of 300 nM [1].
|
-
- HY-157990
-
|
|
Wnt
β-catenin
|
Cancer
|
|
Wnt/β-catenin-in-1 (compounds 17) is a Wnt/β-catenin signaling pathway inhibitor. Wnt/β-catenin-IN-1 can induce apoptosis of colon cancer cells, has broad-spectrum anticancer activity, and can be used for the reseach of a variety of solid tumors [1].
|
-
- HY-135114
-
|
HPCD
|
SARS-CoV
|
Infection
Inflammation/Immunology
|
Hydroxypropyl-beta-cyclodextrin is a SARS-CoV-2 inhibitor. Hydroxypropyl-beta-cyclodextrin has immunomodulatory effects, which can reduce the production of inflammatory cytokines in lung epithelial cells infected by the virus [1].
|
-
- HY-148524
-
|
|
mAChR
Adrenergic Receptor
|
Cardiovascular Disease
|
|
β2AR/M-receptor agonist-1 (example 131) is a muscarinic antagonist and β2 adrenoceptor agonist (MABA). β2AR/M-receptor agonist-1 shows potency to β2 adrenoceptor with an EC50 value of 9.2 nM. β2AR/M-receptor agonist-1 also has potency to muscarinic receptor with a Ki value of 30.2 nM. β2AR/M-receptor agonist-1 shows MABA potency with an EC50 value of 4.0 nM [1].
|
-
- HY-N13705
-
|
|
Others
|
Others
|
|
3β,7β-Dihydroxy-11,15,23-trioxo-lanost-8,16-dien-26-oic acid is a triterpene compound that can be found in Ganoderma lucidum [1].
|
-
- HY-145433
-
|
|
17β-HSD
|
Cancer
|
|
17β-HSD1-IN-1 (Compound 1) is a highly selective 17β-HSD1 inhibitor with IC50s of 5.6 and 3155 nM for 17β-HSD1 and 17β-HSD2, respectively. 17β-HSD1-IN-1 can be used for the research of non-small cell lung cancer (NSCLC) [1].
|
-
- HY-124957
-
|
|
Cholinesterase (ChE)
Apoptosis
|
Cancer
|
|
β-NETA is a potent and noncompetitive choline acetyltransferase (ChA; IC50=76 μM) and cholinesterase (ChE; IC50=40 μM) inhibitor. β-NETA weakly inhibits acetylcholinesterase (AChE; IC50=1 mM) [1] .
|
-
- HY-N8934
-
|
|
Others
|
Cancer
|
|
6β-Hydroxytomentosin, a sesquiterpenoid, can be found in flowers of Inula japonica. 6β-Hydroxytomentosin exhibits weak cytotoxicities against A549, SK-OV-3, HepG-2 and HT-29 cell lines [1] .
|
-
- HY-12452
-
-
- HY-130269
-
|
β-NF-CH2-OH
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
β-Naphthoflavone-CH2-OH (β-NF-CH2-OH) is a ligand for arylhydrocarbon receptor (AhR) E3 ligase. β-Naphthoflavone-CH2-OH can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs (e.g., β-naphthoflavone-JQ1) that recruit the AhR E3 ligase complex by incorporating AhR ligands into chimeric molecules. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins [1].
|
-
- HY-126304
-
|
|
Phosphatase
Endogenous Metabolite
ERK
|
Metabolic Disease
|
|
β-Glycerophosphate disodium salt pentahydrate is a bioactive endogenous metabolite and a phosphatase inhibitor. β-Glycerophosphate disodium salt pentahydrate plays an important role in inducing and maintaining osteoblast differentiation, mineral metabolism and signal transduction, and can be used as a drug carrier to form heat-sensitive hydrogels. β-Glycerophosphate disodium salt hydrate accelerates the calcification of vascular smooth muscle cells [1] .
|
-
- HY-W145559
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Gal[236Bn]β(1-4)Glc[236Bn]-β-MP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
![Gal[236Bn]β(1-4)Glc[236Bn]-β-MP](//file.medchemexpress.com/product_pic/hy-w145559.gif)
- HY-164568
-
|
|
Drug Derivative
|
Cancer
|
|
7β,16α-Dihydroxybufalin is a dihydroxylated derivative of bufalin, which exhibits cytotoxicities against cancer cell lines [1] .
|
-
- HY-P0128F
-
-
- HY-153682
-
|
|
β-catenin
|
Cancer
|
|
β-Catenin modulator-5 (compound IIa-84), an oxazole and thiazole compound, is a potent and selective β-Catenin modulator [1].
|
-
- HY-153680
-
|
|
β-catenin
|
Cancer
|
|
β-Catenin modulator-3 (compound IIa-112), an oxazole and thiazole compound, is a potent and selective β-Catenin modulator [1].
|
-
- HY-153681
-
|
|
β-catenin
|
Cancer
|
|
β-Catenin modulator-4 (compound IIa-92), an oxazole and thiazole compound, is a potent and selective β-Catenin modulator [1].
|
-
- HY-153679
-
|
|
β-catenin
|
Cancer
|
|
β-Catenin modulator-2 (compound IIa-130), an oxazole and thiazole compound, is a potent and selective β-Catenin modulator [1].
|
-
- HY-P3688
-
|
Aβ (1-38); Aβ38
|
Amyloid-β
|
Others
|
|
β-Amyloid (1-38) (Aβ (1-38); Aβ38) is aAβ Fragment.
|
-
- HY-P3515
-
-
- HY-W015084S
-
|
|
Isotope-Labeled Compounds
Apoptosis
|
Cancer
|
|
β-Ionone- 13C3 is the 13C-labeled β-Ionone. β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. Anti-cancer activity[1].
|
-
- HY-113245
-
|
|
Endogenous Metabolite
|
Others
|
|
3-Indolyl-β-D-glucuronide, a chromogenic substrate for β-D-glucuronidase, employs in the detection and enumeration of E. coli, yielding a blue precipitate upon cleavage. 3-Indolyl-β-D-glucuronide in? patients' plasma act as a new indicator of renal failure [1] .
|
-
- HY-W011849
-
|
|
NF-κB
COX
|
Cancer
|
|
Phenyl β-D-glucopyranoside has anti-cancer and anti-inflammatory activities. Phenyl β-D-glucopyranoside inhibits nitric oxide (NO) production, and the expression of iNOS and COX-2. Phenyl β-D-glucopyranoside also inhibits the nuclear translocation of NF-κB [1].
|
-
- HY-P10039
-
|
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (1-16) rat is a β-amyloid peptide (Abeta), a metal-binding domain fragment of amyloid. Three amino acid substitutions in β-Amyloid (1-16) rat that differ from humans render rats and mice less susceptible to AD-like neurodegeneration [1].
|
-
- HY-W104635
-
|
6-Bromo-2-naphthyl-beta-D-galactopyranoside
|
Biochemical Assay Reagents
|
Others
|
|
6-Bromo-2-naphthyl-β-D-galactopyranoside is a chromogenic substrate commonly used to measure β-galactosidase enzyme activity in food, enzyme substrates, and culture media. Upon hydrolysis by β-galactosidase, it generates a yellow precipitate indicating the enzyme's presence.
|
-
- HY-P1854
-
|
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (1-9), an N-terminal fragment of beta amyloid, consists of amino acid residues 1 to 9. β-Amyloid (1-9) contains a B cell epitope, but it does not include T cell epitopes. Omission of residues 1 to 9 from the full-length Alzheimer'sβ-Amyloid peptide 1 to 40 does not prevent the peptide from forming amyloid fibrils or eliminate fibril polymorphism [1] .
|
-
- HY-161094
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
Metallo-β-lactamase-IN-12 is a dual inhibitor of metal β-lactamases (MβLs (NDM-1, IMP-1)) and serine β-lactamases (SβLs (OXA-48, KPC-2)), with IC50 values of 0.64 μM, 1.32 μM, 1.01 μM, and 0.57 μM, respectively. Metallo-β-lactamase-IN-12 has antibacterial activity [1].
|
-
- HY-137198
-
-
- HY-133707S
-
-
- HY-133707S1
-
-
- HY-29268
-
|
|
Bacterial
Indoleamine 2,3-Dioxygenase (IDO)
NF-κB
Phosphodiesterase (PDE)
|
Infection
Inflammation/Immunology
Cancer
|
|
β-Carboline 1-carboxylic acid is a β-carboline alkaloid with anti-inflammatory, antifibrotic, antitumor and antibacterial activities. β-Carboline 1-carboxylic acid is the cAMP phosphodiesterase (IC50: 96 µM) and indoleamine 2, 3-dioxygenase (IDO) inhibitor. β-Carboline 1-carboxylic acid is cytotoxic to tumor cells. β-Carboline 1-carboxylic acid inhibits inflammation through the NF-κb/p65 pathway and can reverse epithelial-mesenchymal transition (EMT). In addition, β-Carboline 1-carboxylic acid has strong inhibitory activity against S. aureus (IC50: 47.70 μg/mL) and E. coli (IC50: 19.17 μg/mL) [1] .
|
-
- HY-157035
-
|
|
Proteasome
|
Others
|
|
Proteasome β2c/i-IN-1 (compound 37) is a subunit-selective human proteasome β2c and β2i inhibitor
[1].
|
-
- HY-100924
-
|
|
GABA Receptor
|
Neurological Disease
|
|
β-CCB is a ligand for benzodiazepine receptor, which inhibits the binding of [ 3H]flunitrazepam and ethyl (3-[ 3H]carboline-3-carboxylate to benzodiazepine receptors, with Ki of 3-4 nM. β-CCB exhibits proconvulsant and anxiogenic effects [1].
|
-
- HY-P3517
-
|
β-EP (6-31), human
|
Opioid Receptor
|
Neurological Disease
Endocrinology
|
|
β-Endorphin, an endogenous opioid neuropeptide, is an opioid receptor agonist. β-Endorphin binds preferentially to μ-opioid receptors and is produced in certain neurons of the central and peripheral nervous system and is one of three endorphins produced in humans. β-Endorphin can be used to reduce stress and maintain homeostasis in the body and is involved in neurological pain perception regulation [1].
|
-
- HY-107670
-
|
DHβE hydrobromide
|
nAChR
|
Neurological Disease
|
|
Dihydro-β-erythroidine (DHβE) hydrobromide is a potent, orally active, and competitive antagonist of neuronal nAChRs. Dihydro-β-erythroidine hydrobromide shows selectivity for α4β4 and α4β2 nAChRs, with IC50s of 0.19 and 0.37 μM, respectively. Antidepressant-like activities [1] .
|
-
- HY-P5370
-
|
|
Amyloid-β
|
Others
|
|
Scrambled β-amyloid (1-40) is a biological active peptide. (Aβ (1-40) together with Aβ (1-42) are two major C-terminal variants of the Aβ protein constituting the majority of Aβs. These undergo post-secretory aggregation and deposition in the Alzheimer’s disease brain. This peptide is the scrambled sequence of Abeta 1-40 HY-P0265)
|
-
- HY-E70054
-
|
CgtB
|
Others
|
Others
|
|
beta-1,3-Galactosyltransferase (WbgO) (CgtB) acts on N-glycan substrates. beta-1,3-Galactosyltransferase (WbgO) catalyzes the formation of type 1 chains on oligosaccharide, glycopeptide, and glycoprotein substrates, including itself [1].
|
-
- HY-N1238
-
|
Δ4-Sitosterol-3-one; β-Rosasterol oxide
|
Tyrosinase
Endogenous Metabolite
|
Cancer
|
|
β-Sitostenone is a sterols that can be isolated from Cochlospermum vitifolium.β-Sitostenone inhibits tyrosinase activity, and has anti-melanogenic and anti-tumor activities [1] .
|
-
- HY-N5137
-
|
OJV-II
|
Others
|
Others
|
|
L-Borneol 7-O-[β-D-apiofuranosyl-(1→6)]-β-D-glucopyranoside is one of the components of the Shengmai injection [1].
|
-
![L-Borneol 7-O-[β-D-apiofuranosyl-(1→6)]-β-D-glucopyranoside](//file.medchemexpress.com/product_pic/hy-n5137.gif)
- HY-148055
-
|
|
Wnt
β-catenin
|
Cardiovascular Disease
|
|
Wnt/β-catenin agonist 3 (compound 98) is a Wnt/β-catenin signalling pathway agonist. Wnt/β-catenin agonist 3 can be used for the research of osteoporosis [1].
|
-
- HY-148055A
-
|
|
Wnt
β-catenin
|
Others
|
|
Wnt/β-catenin agonist 3 hydrochloride is a Wnt/β-catenin signalling pathway agonist. Wnt/β-catenin agonist 3 (compound 98) can be used for the research of osteoporosis [1].
|
-
- HY-N2056R
-
|
|
Lipoxygenase
Leukotriene Receptor
NF-κB
|
Metabolic Disease
Cancer
|
|
11-Keto-beta-boswellic acid (Standard) is the analytical standard of 11-?Keto-?beta-?boswellic acid. This product is intended for research and analytical applications. 11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production [1].
|
-
- HY-N2188
-
-
- HY-124670
-
-
- HY-N1940
-
|
Cycloicaritin
|
Interleukin Related
TNF Receptor
MMP
|
Inflammation/Immunology
Cancer
|
|
β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties [1]. β-Anhydroicaritin ameliorates the degradation of periodontal tissue and inhibits the synthesis and secretion of TNF-α and MMP-3 in diabetic rats . β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca 2+, and markedly decreases iNOS protein expression .
|
-
- HY-W743741
-
-
- HY-W009841
-
-
- HY-W007578
-
-
- HY-W007942
-
-
- HY-W011089
-
-
- HY-N3870
-
|
|
Others
|
Others
|
|
Ethyl β-fructofuranoside is a natural product [1].
|
-
- HY-W015231
-
-
- HY-W013185
-
-
- HY-W012379
-
-
- HY-W012451
-
-
- HY-P5096
-
|
|
Amyloid-β
|
Others
|
|
FITC-β-Ala-Amyloid β-Protein (1-42) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development [1].
|
-
- HY-N0180S
-
|
|
Endogenous Metabolite
|
Inflammation/Immunology
Cancer
|
|
18β-Glycyrrhetinic acid-d3 is deuterium labeled 18β-Glycyrrhetinic acid. 18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhizae Radix and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.
|
-
- HY-137553A
-
|
SM934
|
NOD-like Receptor (NLR)
|
Inflammation/Immunology
|
|
β-Aminoarteether maleate (SM934) is an Artemisinin derivative with orally active. β-Aminoarteether maleate can be used for inflammation and autoimmune disease research, such as lupus diseases [1].
|
-
- HY-145969
-
|
|
DNA/RNA Synthesis
|
Others
|
|
β-S-ARCA is a mRNA 7-methylguanosine (m 7G) cap analog carrying a phosphorothioate (PS) moiety. mRNAs incorporating β-S-ARCA have elongated cellular half-lives and showed augmented protein expression. β-S-ARCA D1 has been applied in researching experimental mRNA-based anticancer vaccines [1].
|
-
- HY-170417
-
|
|
Cholinesterase (ChE)
GSK-3
|
Neurological Disease
|
|
hAChE/hBuChE/GSK-3β-IN-1 (Compound 6c) is a BBB-penetrable and multi-target anti-Alzheimer's disease compound. hAChE/hBuChE/GSK-3β-IN-1 is the inhibitors of hAChE (IC50: 28.88 nM), hBuChE (IC50: 131.90 nM) and GSK-3β (IC50: 51.42 nM). hAChE/hBuChE/GSK-3β-IN-1 is the tau and Aβ protein aggregation inhibitors [1].
|
-
- HY-N9187
-
|
|
Others
|
Others
|
|
1α,4β,10β-Trihydroxyguaia-2,11(13)-dien-12,6α-olide is a Sesquiterpenoids product that can be isolated from the rhizomes of Alisma orientale [1].
|
-
- HY-N2168R
-
|
(+)-Pinoresinol 4-O-β-D-glucopyranoside (Standard)
|
Glycosidase
Estrogen Receptor/ERR
Phosphodiesterase (PDE)
|
Neurological Disease
Metabolic Disease
Cancer
|
|
Pinoresinol 4-O-β-D-glucopyranoside (Standard) is the analytical standard of Pinoresinol 4-O-β-D-glucopyranoside (HY-N2168). This product is intended for research and analytical applications. Pinoresinol 4-O-β-D-glucopyranoside is an orally active α-glucosidase inhibitor, with an IC50 of 48.13 μg/mL. Pinoresinol 4-O-β-D-glucopyranoside binds to estrogen receptors. Pinoresinol 4-O-β-D-glucopyranoside inhibits phosphodiesterase. Pinoresinol 4-O-β-D-glucopyranoside exhibits various activities such as antioxidant, anti-inflammatory, anti-hyperglycemic, hepatoprotective and anti-epileptic effects [1] .
|
-
- HY-E70044
-
|
|
Glycosyltransferase
|
Metabolic Disease
|
|
beta-1, 3-N-Acetylhexaminyltransferase (LgtA) is a glycosyltransferase, is often used in biochemical studies. beta-1, 3-N-Acetylhexaminyltransferase (LgtA) catalyzes the transfer of N-acetylglucosamine from UDP-GlcNAc to N-acetyllactosamine and lactose [1].
|
-
- HY-N7489
-
|
|
Parasite
|
Infection
Inflammation/Immunology
|
|
β-Hederin, a saponin isolated from Hedera helix L.(Araliaceae), possesses antileishmanial activity. β-Hederin exhibits IC50 values of 1.5 μM, 68 nM and 4.57 μM in L. Mexicana promastigotes, L. mexicana amastigotes and THP1 cells, respectively [1] .
|
-
- HY-P2294
-
|
|
TGF-β Receptor
|
Inflammation/Immunology
|
|
pm26TGF-β1 peptide is a peptide that mimics a portion of the human TGF-β1 molecule. pm26TGF-β1 peptide shows high affinity for the TGF-β1 receptor. pm26TGF-β1 peptide displays potent anti-inflammatory properties and does not exhibit neutrophils’ chemoattraction [1] .
|
-
- HY-101895
-
|
FDG
|
Fluorescent Dye
|
Others
|
|
Fluorescein di(β-D-galactopyranoside) is a fluorogenic substrate for β-galactosidase (λex=485 nm, λem=535 nm).
|
-
- HY-141907S
-
-
- HY-144100
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
β-Lactamase-IN-7 (compound 14) is a potent VIM-Type metallo-β-lactamase inhibitor, with Kis of 1.26 μM and 0.54 μM for VIM-1 and VIM-4, respectively. β-Lactamase-IN-7 can effectively inhibit Klebsiella pneumoniae [1].
|
-
- HY-156180
-
|
|
Drug Metabolite
|
Neurological Disease
|
|
DDC 3′-O-β-D glucuronide (compound 5) is a drug metabolite that can prevent the fibrillization and oligomerization of Aβ42. DDC 3′-O-β-D glucuronide has potential for the research of Alzheimer's disease [1].
|
-
- HY-W145656
-
|
alpha,beta-Trehalose
|
Biochemical Assay Reagents
|
Others
|
|
α,β-Trehalose is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-107373
-
|
L-β-Chloroalanine
|
Bacterial
|
Infection
|
|
β-Chloro-L-alanine is a bacteriostatic amino acid analog which inhibits a number of enzymes, including threonine deaminase and alanine racemase.
|
-
- HY-W145637
-
|
Gb3-beta-MP
|
Biochemical Assay Reagents
|
Others
|
|
Gb -β-MP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W145648
-
|
Methyl-beta-D-thiogalactoside
|
Biochemical Assay Reagents
|
Others
|
|
Methyl-β-D-thiogalactoside is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-F0004S
-
|
β-NM-d4; NMN-d4
|
Endogenous Metabolite
|
Neurological Disease
Cancer
|
|
β-Nicotinamide mononucleotide-d4 is the deuterium labeled β-Nicotinamide mononucleotide. β-nicotinamide mononucleotide (β-NM) is a product of the nicotinamide phosphoribosyltransferase (NAMPT) reaction and a key NAD+ intermediate. The pharmacological activities of β-nicotinamide mononucleotide include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity[1].
|
-
- HY-129433
-
|
|
17β-HSD
|
Endocrinology
|
|
17β-HSD1-IN-2 (PBRM) is a non-estrogenic and steroidal covalent irreversible inhibitor of 17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) (Ki=368 nM). 17β-HSD1-IN-2 can be used for the research of estrogen-dependent disorders [1].
|
-
- HY-E70068
-
|
|
Others
|
Others
|
|
Endo-β-N-acetylglucosaminidase (Endo S) is a family 18 glycosyl hydrolase secreted by Streptococcus pyogenes. Endo-β-N-acetylglucosaminidase (Endo S) exclusively hydrolyzes the β-1,4-di-N-acetylchitobiose core of the asparagine-linked complex-type glycan on Asn-297 of the γ-chains of IgG antibody [1].
|
-
- HY-160489
-
|
|
β-catenin
Wnt
|
Cancer
|
|
PTK7/β-catenin-IN-2 (compound 04967) is an inhibitor of PTK7/β-catenin. It inhibits the binding of PTK7 to β-catenin (IC50: 5.6 μM), thereby inhibiting the signaling of the Wnt/β-catenin pathway. PTK7/β-catenin-IN-2 targets cell growth dependent on the Wnt signaling pathway and has anticancer properties. PTK7/β-catenin-IN-2 also showed inhibitory potency against p53 and MDM2 binding with an IC50 of 157.1 μM [1].
|
-
- HY-P3275
-
|
Aβ(17-40)
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (17-40) (Aβ(17-40)) is a fragment of Amyloid-β peptide that has shown neurotoxic activities in SH-SY5Y and IMR-32 cells. β-Amyloid (17-40) can be used for the research of neurological disease [1].
|
-
- HY-P3845
-
|
|
Amyloid-β
|
Neurological Disease
|
|
(Gly22)-Amyloid β-Protein (1-42) is a peptide fragment of amyloid β-protein (Aβ). Amyloid β-protein is the primary component of both vascular and parenchymal amyloid deposits in Alzheimer's disease. Mutation of Glu22 to Gly22 in Aβ can increase aggregation [1] .
|
-
- HY-151643
-
|
|
ADC Linker
|
Others
|
|
beta-Glc-TEG-Alkyne is a click chemistry reagent containing an alkynes group. beta-Glc-TEG-Alkyne can be used for the research of various biochemical [1].
|
-
- HY-W699180
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Fuc1-α-2Gal1-β-3GlcNAc-β-PNP is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology [1].
|
-
- HY-D1224
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Chlorophenol red-β-D-galactopyranoside is a long-wavelength dye, which has been widely used for colorimetric assays. Chlorophenol red-β-D-galactopyranoside is also a β-D-Galactosidase (HY-P2869I) substrate commonly used in recombinant yeast oestrogenic assays [1] .
|
-
- HY-E70393E
-
|
|
Angiotensin Receptor
|
Others
|
|
Human Factor XIIa Beta is the active fragment of coagulation factor XII, that participates in the intrinsic pathway of coagulation, and leads to the formation of blood clots. Human Factor XIIa Beta also participates in the kinin-generating pathway, which leads to the release of bradykinin (vasodilator). Human Factor XIIa Beta stimulates the release of catecholamines, and mediates its cardiovascular effects through a noncholinergic angiotensin-converting enzyme (ACE)-regulated mechanism [1].
|
-
- HY-E70393I
-
|
|
Others
|
Others
|
|
Bovine Factor IXa Beta is an inactive and highly specific enzyme, with a minimal extended substrate recognition site and a preference for particular amino acid residues at specific subsites. Bovine Factor IXa Beta plays a role in the blood coagulation cascade [1].
|
-
- HY-W197533
-
|
|
Others
|
Neurological Disease
|
|
3-Hydroxymethyl-β-carboline antagonizes the anxiolytic and anticonvulsant actions of Diazepam and reverses the sedative action of Flurazepam. 3-Hydroxymethyl-β-carboline also antagonizes the cerebrovascular and cerebral metabolic depression produced by Flurazepam [1] .
|
-
- HY-W049881
-
|
|
Dopamine Receptor
|
Neurological Disease
Inflammation/Immunology
|
|
9-Methyl-β-carboline is a cognitive enhancer with neuroprotective, neurorestorative and anti-inflammatory properties. The behavioral effects of 9-Methyl-β-carboline may be related to the stimulation of hippocampal dopamine levels and dendritic and synaptic proliferation [1].
|
-
- HY-141379
-
|
|
PROTAC Linkers
ADC Linker
|
Cancer
|
|
N-Bromoacetyl-β-alanine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs [1]. N-Bromoacetyl-β-alanine is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
|
-
- HY-141530
-
-
- HY-W127512
-
|
|
Drug Intermediate
|
Others
|
|
5β-Cholanic acid is a hydrophobic modifier used to modify polymer carriers. 5β-Cholanic acid can improve the acid stability, cell penetration efficiency and drug sustained release ability of nanocarriers, and optimize the oral effectiveness of delivered molecules. 5β-Cholanic acid can covalently bind to Glycol chitosan (GC) to form a GC-CA conjugate, which optimizes the hydrophobic anchoring ability of nanoparticles and enables them to be stably adsorbed on the surface of PLGA nanoparticles. Such nanoparticles can resist dissociation in the gastric acid environment and maintain positive charge to enhance endocytic uptake by intestinal epithelial cells (such as Caco-2 cells). 5β-Cholanic acid can be used in the development of drug delivery systems [1] .
|
-
- HY-P991101
-
|
|
Amyloid-β
|
Neurological Disease
|
|
Anti-Amyloid Beta Antibody (scFv59) is a human antibody expressed in CHO cells, targeting Amyloid-β. Anti-Amyloid Beta Antibody (scFv59) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-N6824
-
|
|
Others
|
Others
|
|
Hydroxy-β-sanshool is an alkylamide exists in Zanthoxylum bungeanum oil and Zanthoxylum schinifolium oil [1].
|
-
- HY-N10983
-
|
|
Others
|
Others
|
|
13β-Hydroxylupanine is a natural product that can be found in Caulophyllum robustum Maxim [1].
|
-
- HY-148378
-
|
|
Drug Intermediate
|
Others
|
|
5β-Dihydrocortisone acetate can be used for the synthesis of tetrahydrocortisone 3-glucuronide [1].
|
-
- HY-N9277
-
|
|
Others
|
Others
|
|
β-Furoyleupatolide (Compound 2) is a compound that can be isolated from Helogyne apaloidea [1].
|
-
- HY-N11026
-
|
|
Others
|
Others
|
|
22-Beta-Acetoxyglycyrrhizin is a triterpene glucuronide that can be isolated from the roots of Glycyrrhiza [1].
|
-
- HY-N2930
-
|
|
Others
|
Others
|
|
β-Peltoboykinolic acid is a Triterpenoids product that can be isolated from the rhizomes of Astilbe koreana. [1].
|
-
- HY-N12342
-
|
|
Others
|
Others
|
|
17β-Tanghinigenin is a kind of glucos-3-ulosyl-thevetoside [1].
|
-
- HY-N2928
-
|
|
Others
|
Others
|
|
β-Dihydroplumericinic acid is a Iridoids product that can be isolated from the herbs of Plumeria rubra [1].
|
-
- HY-P9984
-
|
rhuMAb beta7; RG7413; PRO145223
|
Integrin
|
Cancer
|
|
Etrolizumab (rhuMAb Beta7) is a gut-selective, anti-β7 integrin monoclonal antibody. Etrolizumab is specific targeting of the β7 subunit of α4β7 and αEβ7 integrins with Ki values of 18 nM and 1800 pM for Human α4β7 and Human αEβ7-293, respectively. Etrolizumab can be used in research of inflammatory bowel disease (IBD) [1] .
|
-
- HY-139924S
-
-
- HY-N1590
-
|
|
Fungal
|
Others
|
|
8β,18-Dihydroxysandaracopimar-15-ene is a compound isolated from Thuja orientalis [1].
|
-
- HY-170663
-
|
|
Glycosyltransferase
|
Infection
|
|
β-1,4-GALT1-IN-1 (Compound 6) is a β-1,4-GALT1 inhibitor, with an IC50 value of 6.2 μM. β-1,4-GALT1-IN-1 can be used in many pathology investigations such as cancer, autoimmune diseases and viral infections [1].
|
-
- HY-N9830
-
|
|
Others
|
Others
|
|
7β-Hydroxycucurbitacin B is a natural product [1].
|
-
- HY-167570
-
-
- HY-N1633
-
|
|
Others
|
Others
|
|
1-Methoxycarbonyl-β-carboline is a natural alkaloid [1].
|
-
- HY-W415981
-
-
- HY-N9310
-
|
|
Others
|
Others
|
|
6-Deoxy-3-O-methyl-beta-allopyranosyl(1-4)-beta-cymaronic acid delta-lactone is a natural product [1].
|
-
- HY-152982
-
-
- HY-E70070
-
|
|
Bacterial
|
Others
|
|
Endo-β-N-acetylglucosaminidase (Endo A) is an Endo-β-N-acetylglucosaminidases (ENGases) from Arthrobacter protophormiae. Endo-β-N-acetylglucosaminidase (Endo A) can transfer a high-mannose type oligosaccharide to monosaccharides such as N-acetylglucosamine (GlcNAc) and glucose to form a new oligosaccharide. Endo-β-N-acetylglucosaminidase (Endo A) catalyzes glycopeptide synthesis by using Man3GlcNAc-oxazoline [1].
|
-
- HY-155534
-
|
|
Endogenous Metabolite
|
Others
|
|
17β-HSD10-IN-1 (compound 9) is an orally active inhibitor of 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10) with blood-brain permeability. 17β-HSD10-IN-1 doesn't result additional effects for mitochondrial off-targets and cytotoxic or neurotoxic effects [1].
|
-
- HY-103081
-
|
|
β-glucuronidase
Bacterial
|
Infection
Cancer
|
|
β-Glucuronidase-IN-1 is a potent, selective, uncompetitive, and orally active E. coli bacterial β-glucuronidase inhibitor, exhibiting an IC50 and a Ki of 283 nM and 164 nM, respectively [1].
|
-
- HY-116011
-
|
|
Drug Intermediate
|
Cancer
|
|
N,N'-bis-Cbz-β-Alethine is an active ester used in the synthesis of β-alethine, which induces cell differentiation and has potential anti-tumor applications. β-Alethine is synthesized by removing the carbobenzoxy (CBZ) groups with hydrogen bromide in glacial acetic acid.
|
-
- HY-135103S
-
|
|
FXR
|
Cancer
|
|
Tauro-β-muricholic acid-d4 (sodium) is the deuterium labeled Tauro-β-muricholic acid sodium. Tauro-β-muricholic Acid sodium (T-βMCA sodium), a endogenous metabolite, is a competitive and reversible farnesoid X receptor (FXR) antagonist, with an IC50 of 40 μM[1][2][3].
|
-
- HY-155535
-
|
|
Endogenous Metabolite
|
Neurological Disease
|
|
17β-HSD10-IN-2 (compound 11) is a benzothiazolylurea-based inhibitor，targeting to 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10)，a multifunctional mitochondrial enzyme. 17β-HSD10-IN-2 don't lead to mitochondrial off-targets and cytotoxic or neurotoxic effects. 17β-HSD10 inhibitors can be used for research in Alzheimer's disease (AD) and hormone-dependent cancer [1].
|
-
- HY-P1387
-
|
|
Amyloid-β
Apoptosis
|
Neurological Disease
|
|
β-Amyloid (1-40) (rat) is a rat form of the amyloid β-peptide, which accumulates as an insoluble extracellular deposit around neurons, giving rise to the senile plaques associated with Alzheimer's disease (AD). β-Amyloid (1-40) (rat) increases 45Ca 2+ influx, induces neurodegeneration in the rat hippocampal neurons of the CA1 subfield. β-Amyloid (1-40) (rat) induces apoptosis. β-Amyloid (1-40) (rat) can be used for the research of Alzheimer's disease [1] .
|
-
- HY-155391
-
|
|
Carbonic Anhydrase
P-glycoprotein
Wnt
β-catenin
|
Cancer
|
|
hCA/Wnt/β-catenin-IN-1 (Compd 15) is an inhibitor of hCA (Ki: 33.6, 24.1, 6.8 nM for hCA II, hCA IX, hCA XII). hCA/Wnt/β-catenin-IN-1 reduces P-gp activity. hCA/Wnt/β-catenin-IN-1 also inhibits Wnt/β-catenin signaling pathway. hCA/Wnt/β-catenin-IN-1 inhibits cancer cell viability, including the NCI/ADR-RES DOX-resistant cell line [1].
|
-
- HY-123633
-
|
|
Glycosidase
|
Others
|
|
4-Methylumbelliferyl β-D-Glucopyranoside, a β-D-glucoside, is a fluorogenic substrate for β-glucosidase, utilizes to assay β-glucosidase activity [1]. 4-Methylumbelliferyl β-D-Glucopyranoside releases the highly fluorescent 4-methylumbelliferyl (4-MU), which has an emission maximum at 445-454 nm. The excitation maximum for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively .
|
-
- HY-137396
-
|
|
Endogenous Metabolite
|
Cardiovascular Disease
|
|
6β-Hydroxy Eplerenone is a metabolite of Eplerenone (HY-B0251). 6β-Hydroxy Eplerenone plays an important role in the research of hypertension, atherosclerosis, chronic systolic heart failure (HF) and cardiovascular (CV) [1].
|
-
- HY-W588194S
-
-
- HY-E70191
-
|
EC:2.4.1.22; B4GALT2
|
Glycosyltransferase
|
Others
|
|
β-1,4-Galactosyltransferase 2 catal exclusive specificity for the donor substrate UDP-galactose and all transfer galactosein a beta1,4 linkage [1].
|
-
- HY-172586
-
|
|
GSK-3
PKA
|
Neurological Disease
Cancer
|
|
GSK-3α/β-IN-1 is GSK-3α/β inhibitor with IC50 s of 0.265 μM and 0.255 μM for GSK-3α and GSK-3β, respectively. GSK-3α/β-IN-1 also inhibits PKA with an IC50 of 0.188 μM. GSK-3α/β-IN-1 potently inhibits cell viability of three Glioblastoma (GBM) cell lines (IC50 : 3-6 μM, 72 h) with no toxicity to human astrocytes and good metabolic stability. GSK-3α/β-IN-1 has potential CNS activity in all-human blood-brain barrier (BBB) model of GBM [1].
|
-
- HY-W130965
-
|
|
Influenza Virus
Akt
|
Infection
|
|
1-Formyl-beta-carboline is an alkaloid with inhibitory activity against Newcastle disease virus (NDV). 1-Formyl-beta-carboline can effectively inhibit different genotypes of NDV with IC50 values within 10 μM, and its inhibition rate is more than 90% at a concentration of 20 μM. 1-Formyl-beta-carboline mainly exerts its effects by inhibiting the adsorption and entry processes in the NDV life cycle. 1-Formyl-beta-carboline has been identified as a novel HN inhibitor that can directly interact with the NDV HN protein and affect the adsorption of NDV. 1-Formyl-beta-carboline also inhibits the entry of NDV by inhibiting the PI3K/Akt signaling pathway rather than the ERK pathway [1].
|
-
- HY-P1363F1
-
|
Biotin-amyloid β-peptide (1-42) (human) TFA
|
Amyloid-β
|
Neurological Disease
|
|
Biotin-β-Amyloid (1-42), human TFA (Biotin-Amyloid β-Peptide (1-42) (human) TFA) is the botin labeled β-Amyloid (1-42), human TFA (HY-P1363). β-Amyloid (1-42), human TFA is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease [1].
|
-
- HY-N1525
-
|
|
Others
|
Others
|
|
Quinovic acid 3-O-(6-deoxy-β-D-glucopyranoside) 28-O-β-D-glucopyranosyl ester is a Triterpenoids product that can be isolated from the vines of Uncaria tomentosa [1].
|
-
- HY-W288349
-
-
- HY-22306S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
β-D-Glucose pentaacetate- 13C6 is the 13C labeled β-D-Glucose pentaacetate[1]. β-D-Glucose Pentaacetate (Penta-O-acetyl-β-D-glucopyranose) is used in biochemical reaction.
|
-
- HY-D0935A
-
|
MUG
|
β-glucuronidase
Fluorescent Dye
|
Others
|
|
4-Methylumbelliferyl-β-D-glucuronide hydrate is a fluorogenic substrat (λex=362 nm, λem=445 nm). 4-Methylumbelliferyl-β-D-glucuronide hydrate has potential applications in detecting the activity of β-glucuronidase and the number of Escherichia coli [1] .
|
-
- HY-160053
-
|
|
PDGFR
|
Cancer
|
|
Gint4.T aptamer sodium is a nuclease-resistant RNA aptamer-based antagonist targeting platelet-derived growth factor receptor beta (PDGFRβ) (Kd: 9.6 nM). Gint4.T aptamer sodium inhibits PDGFRβ heterodimerization and EGFR transactivation. It can significantly inhibit cell migration and proliferation, induce differentiation and prevent tumor growth in vivo. Gint4.T aptamer sodium specifically inhibits PDGFRβ-mediated tropism of mesenchymal stem cells (MSCs) toward the tumor microenvironment [1].
|
-
- HY-123090
-
|
|
11β-HSD
|
Metabolic Disease
|
|
11β-HSD1-IN-12 is a 11β-HSD1 inhibitor (Example 21 in reference patent). 11β-HSD1 regenerates active glucocorticoids from inactive forms and is important in regulating intracellular glucocorticoid concentration. 11β-HSD1-IN-12 can be used in the research of obesity and metabolic syndrome [1].
|
-
- HY-N0171AR
-
|
|
Apoptosis
Endogenous Metabolite
|
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
|
Beta-Sitosterol (purity>98%) (Standard) is the analytical standard of Beta-Sitosterol (purity>98%). This product is intended for research and analytical applications. Beta-Sitosterol (purity>98%) is a plant sterol. Beta-Sitosterol (purity>98%) interfere with multiple cell signaling pathways, including cell cycle, apoptosis, proliferation, survival, invasion, angiogenesis, metastasis and inflammation [1].
|
-
- HY-W011183
-
|
|
Biochemical Assay Reagents
|
Metabolic Disease
|
|
4-Nitrophenyl-N-acetyl-β-D-glucosaminide, an artificial substrate of N-acetyl-beta-D-hexosaminidase (NAGase), can be used in rapid and accurate rate assay for N-acetyl-beta-D-hexosaminidase. 4-Nitrophenyl-N-acetyl-β-D-glucosaminide is highly soluble and stable. 4-Nitrophenyl-N-acetyl-β-D-glucosaminide can be used for the study of renal tubular injury [1] .
|
-
- HY-N9268
-
|
|
Others
|
Others
|
|
8β-Tigloyloxyreynosin is a Sesquiterpenoids product that can be isolated from the roots of Dolomiaea souliei [1].
|
-
- HY-N1017
-
|
|
Others
|
Others
|
|
11β-Hydroxycedrelone is a natural tetranortriterpenoid compound isolated from the bark of Walsura yunnanensis [1].
|
-
- HY-119866
-
-
- HY-N2744
-
|
|
Others
|
Others
|
|
7beta-Hydroxyrutaecarpine is a Alkaloids product that can be isolated from the fruits of Euodia ruticarpa [1].
|
-
- HY-N1721
-
|
|
Others
|
Others
|
|
2β-Hydroxykolavelool is a Diterpenoids product that can be isolated from the tubers of Sagittaria trifolia [1].
|
-
- HY-N1617
-
|
|
Others
|
Others
|
|
1beta-Hydroxytorilin is a Sesquiterpenoids product that can be isolated from the fruits of Torilis japonica. [1].
|
-
- HY-P1502
-
|
|
Opioid Receptor
|
Neurological Disease
|
|
β-Endorphin, human, a prominent endogenous peptide, existing in the hypophysis cerebri and hypothalamus, is an agonist of opioid receptor, with preferred affinity for μ-opioid receptor and δ-opioid receptor; β-Endorphin, human exhibits antinociception activity.
|
-
- HY-136537A
-
-
- HY-W687950
-
-
- HY-163037
-
-
- HY-W033010
-
|
β-Tropine
|
Drug Derivative
|
Others
|
|
Pseudotropine (β-Tropine), a derivative of Tropane, is a plant alkaloid [1].
|
-
- HY-113019
-
-
- HY-P1524
-
-
- HY-137382
-
-
- HY-122084
-
-
- HY-P1363A
-
|
Amyloid β-peptide (1-42) (human)
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (1-42), human (Amyloid β-peptide (1-42), human) is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease [1] .
|
-
- HY-N15521
-
|
|
Epoxide Hydrolase
|
Inflammation/Immunology
|
|
Moracin M 3’-O-β-glucopyranoside is found in Morus alba. Moracin M 3’-O-β-glucopyranoside is a sEH inhibitor (IC50: 7.7 µM). Moracin M 3’-O-β-glucopyranoside exhibits anti-inflammatory activity [1].
|
-
- HY-N10593
-
|
|
Reactive Oxygen Species
|
Cardiovascular Disease
|
|
Ladanetin-6-O-β-D-glucopyranoside is an active flavonoid. Ladanetin-6-O-β-D-glucopyranoside has antioxidative effect. Ladanetin-6-O-β-D-glucopyranoside can be used for the research of cardioprotective effects [1].
|
-
- HY-W603112
-
|
|
Biochemical Assay Reagents
|
Others
|
|
β-D-Glucopyranosyl 1-thio-β-D-glucopyranoside is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology [1].
|
-
- HY-W416257
-
|
|
Biochemical Assay Reagents
|
|
|
Methyl 3-O-β-D-galactopyranosyl-β-D-galactopyranoside is a class of biochemical reagent used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It deals with carbohydrate chemistry, glycan formation and degradation enzymology, protein-glycan recognition, and the role of glycans in biological systems. The field is closely related to basic research, biomedicine and biotechnology [1].
|
-
- HY-N5111
-
|
Aloe-emodin 3-O-β-D-glucoside
|
Others
|
Others
|
|
Aloe-emodin-3-(hydroxymethyl)-O-β-D-glucopyranoside (Aloe-emodin 3-O-β-D-glucoside) is a natural antraquinone [1].
|
-
- HY-144513S
-
-
- HY-P5811
-
|
CcoTx1; β-TRTX-cm1a
|
Sodium Channel
|
Neurological Disease
|
|
Ceratotoxin-1 (CcoTx1), a peptide toxin, is an voltage-gated sodium channel subtypes inhibitor. Ceratotoxin-1 inhibits Nav1.1/β1, Nav1.2/β1, Nav1.4/β1, and Nav1.5/β1 with IC50 of 523 nM, 3 nM, 888 nM, and 323 nM, respectively. Ceratotoxin-1 also inhibits Nav1.8/β1 [1].
|
-
- HY-18593
-
|
6-O-alpha-D-Maltosyl-beta-cyclodextrin
|
Biochemical Assay Reagents
|
Others
|
|
Mal-β-CD is a cellular cholesterol modifier which can form soluble inclusion complex with cholesterol.
|
-
- HY-N10944
-
|
|
Others
|
Inflammation/Immunology
|
|
Chrysoobtusin 2-β-D-glucoside is an anthraquinone glycoside found in Cassia obtusifolia. Chrysoobtusin 2-β-D-glucoside may have potential anti-inflammatory and antioxidant activities [1].
|
-
- HY-N3554
-
|
(+)-Catechol 7-β-D-xylopyranoside
|
Others
|
Others
|
|
Catechin-7-O-β-D-xylopyranoside is an antioxidant compound with strong DPPH free radical scavenging ability. Catechin-7-O-β-D-xylopyranoside can be extracted from birch inner bark and nepeta stem bark [1] .
|
-
- HY-P3846
-
|
|
Amyloid-β
|
Neurological Disease
|
|
(Glu20)-Amyloid β-Protein (1-42) is a slower fibrillizing variant of amyloid β-protein (Aβ). The Glu20 mutation reduces the aggregation propensity of Aβ42 and prevents accumulation of the slowly fibrillizing peptide. Amyloid β-protein is the primary component of both vascular and parenchymal amyloid deposits in Alzheimer's disease [1] .
|
-
- HY-160488
-
|
|
β-catenin
|
Cancer
|
|
PTK7/β-catenin-IN-1 (compound 01065) is a potent PTK7/β-catenin inhibitor with an IC50 of 8.9 μM and 56.5 μM for PTK7/β-catenin and p53/MDM2, respectively. PTK7/β-catenin-IN-1 has the potential for cancer research [1].
|
-
- HY-150511
-
|
|
Microtubule/Tubulin
Apoptosis
|
Cancer
|
|
3-(3-Phenoxybenzyl)amino-β-carboline is a potent tubulin inhibitor. 3-(3-Phenoxybenzyl)amino-β-carboline promotes selective degradation of αβ-tubulin heterodimers. 3-(3-Phenoxybenzyl)amino-β-carboline induces G2/M phase cell cycle arrest and apoptosis. 3-(3-Phenoxybenzyl)amino-β-carboline exhibits anticancer activity [1].
|
-
- HY-N0406R
-
|
|
Others
|
Inflammation/Immunology
|
|
2"-O-beta-L-galactopyranosylorientin (Standard) is the analytical standard of 2"-O-beta-L-galactopyranosylorientin. This product is intended for research and analytical applications. 2"-O-beta-L-galactopyranosylorientin is extracted from the flowers of Trollius ledebouri. 2"-O-beta-L-galactopyranosylorientin involves transporter mediated efflux in addition to passive diffusion and is the substrate of multidrug resistance protein 2 (MRP2). Anti-inflammatory effect [1] .
|
-
- HY-143613A
-
|
|
Thyroid Hormone Receptor
|
Metabolic Disease
|
|
THR-β agonist 2 diacetate (Compound 3) is a potent agonist of THR-β. THR-β agonist 2 diacetate has the potential for the research of metabolic diseases such as obesity, hyperlipidemia, hypercholesterolemia, diabetes and other conditions such as steatosis and non-alcoholic steatohepatitis (NASH), atherosclerosis and other related conditions and diseases [1].
|
-
- HY-118774R
-
|
|
Endogenous Metabolite
|
Inflammation/Immunology
|
|
Propofol β-D-glucuronide (Standard) is the analytical standard of Propofol β-D-glucuronide. This product is intended for research and analytical applications. Propofol β-D-glucuronide is a metabolite of Propofol sulfate and can be used for diagnosis to distinguish colorectal cancer from healthy individuals [1].
|
-
- HY-W039920
-
|
β-D-Galactosylamine, 98%
|
Biochemical Assay Reagents
|
Others
|
|
1-Amino-1-deoxy-β-D-galactose, 98% is a galactose analog used as a competitive inhibitor to aid in the separation, purification, identification, differentiation, and characterization of β-D-galactosidase and galactose oxidase.
|
-
- HY-W145622
-
|
Gal beta(1-3)[Neu5Ac alpha(2-6)]GlcNAc-beta-pNP
|
Biochemical Assay Reagents
|
Others
|
|
Galβ(1-3)[Neu5Acα(2-6)]GlcNAc-β-pNP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
![Galβ(1-3)[Neu5Acα(2-6)]GlcNAc-β-pNP](//file.medchemexpress.com/product_pic/hy-w145622.gif)
- HY-N9081
-
|
|
Others
|
Others
|
|
6β-Hydroxyhispanone is a Diterpenoids product that can be isolated from the aerial parts of Leonurus japonicus [1].
|
-
- HY-135577
-
|
|
Drug Metabolite
|
Infection
|
|
β-Apooxytetracycline is a degradation product of Oxytetracycline (HY-B0275). Oxytetracycline is a widespread antibiotic [1].
|
-
- HY-N2667
-
|
|
Others
|
Others
|
|
5β-Hydroxycostic acid is a Sesquiterpenoids product that can be isolated from the roots of Aucklandia lappa Decne [1].
|
-
- HY-W008917S1
-
-
- HY-146760S
-
-
- HY-N1831
-
|
|
Others
|
Others
|
|
3-Eudesmene-1beta,11-diol is a Sesquiterpenoids product that can be isolated from the herbs of Physalis alkekengi [1].
|
-
- HY-N10996
-
|
|
Others
|
Others
|
|
(3β)-3-Hydroxyoleanan-12-one (compound 23) is a natural product that can be found in Codonopsis ovata [1].
|
-
- HY-126304A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Glycerophosphoric acid (disodium salt hydrate) (α and β mixture) is a complex contains α and β Glycerophosphoric acid isomers.
|
-
- HY-N13704
-
|
|
Others
|
Others
|
|
(19S,23E)-5β,19-Epoxy-19-methoxycucurbita-6,23,25-trien-3β-ol is an active compound.
|
-
- HY-N0171B
-
|
β-Sitosterol (purity>75%); 22,23-Dihydrostigmasterol (purity>75%)
|
Apoptosis
|
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
|
Beta-Sitosterol (purity>75%) is a phytosterol with oral activity. Beta-Sitosterol (purity>75%) interferes with a variety of cell signaling pathways, including the cell cycle, apoptosis and cell proliferation. Beta-Sitosterol (purity>75%) has anti-inflammatory, antioxidant, and antitumor activities [1] .
|
-
- HY-N3872
-
|
|
Others
|
Others
|
|
Ethyl β-D-glucopyranoside (compound 10) is a kind of phenolic compound. Ethyl β-D-glucopyranoside can be isolated from ethanolic extract of Scabiosa stellata LS.
|
-
- HY-W040224
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Octyl β-D-thioglucopyranoside is a non-ionic detergent that can be used in the field of membrane biochemistry. Octyl β-D-thioglucopyranoside has the ability to solubilize E. coli membrane proteins [1].
|
-
- HY-P99222
-
|
MGA-031; PRV-031
|
CD3
|
Metabolic Disease
|
|
Teplizumab (MGA-031) is a Fc receptor non-binding anti-human CD3 monoclonal antibody. Teplizumab reduces the loss of beta-cell function. Teplizumab can be used in the research of type 1 diabetes [1] .
|
-
- HY-N6616R
-
|
|
Others
|
Others
|
|
Pinocembrin-7-O-β-D-glucopyranoside (Standard) is the analytical standard of Pinocembrin-7-O-β-D-glucopyranoside. This product is intended for research and analytical applications. Pinocembrin-7-O-β-D-glucopyranoside (Pinocembrin 7-O-β-D-Glucoside) is is a flavanone that enhances lipid peroxidation [1].
|
-
- HY-134924
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Succinyl-β-cycloaltrin is a modified cyclodextrin with unique chemical properties that make it an effective solubilizer and stabilizer for various compounds, especially in the pharmaceutical industry. Succinyl-β-cycloaltrin has a hydrophobic interior and a hydrophilic exterior, enabling it to form stable clathrates with hydrophobic molecules such as drugs and nutrients. This increases their solubility and bioavailability, making them more effective for recreational or nutritional purposes.
|
-
- HY-145969A
-
|
|
DNA/RNA Synthesis
|
Cancer
|
|
β-S-ARCA (triammonium) is a mRNA 7-methylguanosine (m 7G) cap analog carrying a phosphorothioate (PS) moiety. mRNA incorporating β-S-ARCA (triammonium) can prolong cellular half-life and increase protein expression. β-S-ARCA (triammonium) can be used in research of mRNA-based anti-cancer vaccines [1].
|
-
- HY-N2769
-
|
|
Others
|
Others
|
|
9β-Hydroxy-ageraphorone is a natural cadinene sesquiterpene compound [1].
|
-
- HY-W739772
-
-
- HY-P1286A
-
-
- HY-W587779
-
|
|
Biochemical Assay Reagents
|
|
|
o-Nitrophenyl β-D-galactopyranoside-6-phosphate cyclohexylammonium is a chromogenic substrate with activity for β-galactosidase detection. The use of o-Nitrophenyl β-D-galactopyranoside-6-phosphate cyclohexylammonium can help researchers quickly identify and quantify β-galactosidase activity.
|
-
- HY-W007497S
-
-
- HY-W604882
-
|
Orthonitrophenyl-beta-D-fucopyranoside, 98%
|
Biochemical Assay Reagents
|
Others
|
|
Orthonitrophenyl-β-D-fucopyranoside, 98% is a chromogenic substrate used in various enzyme assays to detect the presence of fucosidase.
|
-
- HY-N13541
-
|
|
Others
|
Others
|
|
(19S,23R)-5β,19-Epoxy-19,23-dimethoxycucurbita-6,24-dien-3β-ol is a natural product [1].
|
-
- HY-162026
-
|
|
11β-HSD
|
Metabolic Disease
|
|
11β-HSD1-IN-14 (Compound 17) is a selective inhibitor for 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1), with IC50 of 74 nM for human HSD1, and 603 nM for HSD1 expressed HEK293 cell [1].
|
-
- HY-P2294A
-
|
|
TGF-β Receptor
|
Inflammation/Immunology
|
|
pm26TGF-β1 TFA peptide is a peptide that mimics a portion of the human TGF-β1 molecule. pm26TGF-β1 peptide TFA shows high affinity for the TGF-β1 receptor. pm26TGF-β1 peptide TFA displays potent anti-inflammatory properties and does not exhibit neutrophils’ chemoattraction [1] .
|
-
- HY-W701013
-
-
- HY-N3658
-
|
|
Others
|
Others
|
|
Cycloart-25-ene-3β,24-diol is a natural triterpene [1].
|
-
- HY-151520
-
|
|
Wnt
|
Cancer
|
|
Wnt/β-catenin agonist 4 (Derivative 83) is an agonist of Wnt that activates Wnt/β-catenin signal transmission [1].
|
-
- HY-W714951S
-
-
- HY-137854
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Naphthol AS-BI N-acetyl-β-D-glucosaminide acts as a substrate and reacts directly with N-acetyl-β-glucosaminidase enzyme. Naphthol AS-BI N-acetyl-β-D-glucosaminide can detect and localize the active region of N-acetyl-β-glucosaminidase enzyme visually [1].
|
-
- HY-P1567
-
|
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (10-35), amide is composed of 26 aa (10-35 residues of the Aβ peptide) and is the primary component of the amyloid plaques of Alzheimer’s disease.
|
-
- HY-148002
-
|
|
Drug Metabolite
|
Others
|
|
1'-Hydroxy Midazolam-β-D-glucuronide is a β-D-glucuronide that acts as a drug metabolite, human urine metabolite, and human serum metabolite [1].
|
-
- HY-134425
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
β-Methylcrotonyl coenzyme A lithium is an intermediate in leucine metabolism and can be used as a substrate to study the specificity and kinetics of β-methylcrotonyl coenzyme A carboxylase (MCCase) [1].
|
-
- HY-N15523
-
|
|
Others
|
Others
|
|
Moracin M 6-β-D-glucopyranoside is found in Morus alba. Moracin M 6-β-D-glucopyranoside is a derivative of coumarin compounds [1].
|
-
- HY-124463
-
-
- HY-N1152
-
|
|
Others
|
Inflammation/Immunology
|
|
threo-Guaiacylglycerol beta-coniferyl ether is a lignan that can inhibit NO production. threo-Guaiacylglycerol beta-coniferyl ether exhibits anti-neuroinflammatory activities [1].
|
-
- HY-N2926
-
|
|
Parasite
|
Infection
|
|
β-Carboline-1-propionic acid is a alkaloid which can be extracted from Ailanthus altissima. β-Carboline-1-propionic acid can be used as an antileishmanial agent [1] .
|
-
- HY-P9911A
-
|
|
Integrin
|
Inflammation/Immunology
|
|
Vedolizumab (anti-α4β7-integrin) is a humanized IgG1 monoclonal antibody that targets the α4β7 integrin for the treatment of ulcerative colitis and Crohn's disease [1] .
|
-
- HY-N12079
-
|
|
Biochemical Assay Reagents
|
Cancer
|
|
(2,4-Dichloro-3,5-dimethoxyphenyl) methyl 6-O-β-D-glucopyranosyl-β-D-glucopyranoside is an anticancer agent that inhibits the proliferation of lung cancer A549 cells (IC50=29 μΜ). (2,4-Dichloro-3,5-dimethoxyphenyl) methyl 6-O-β-D-glucopyranosyl-β-D-glucopyranoside can be obtained from Lilium regale and can be used in cancer research [1].
|
-
- HY-W015084
-
|
|
Apoptosis
|
Cancer
|
|
β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. Anti-cancer activity [1].
|
-
- HY-W145581
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Triacetyl-β-cyclodextrin is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-P2763
-
|
|
Biochemical Assay Reagents
|
Others
|
|
beta-Glucanase is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-N11498
-
|
|
Others
|
Others
|
|
β-Obscurine is a lycopodine-type alkaloid, which can be isolated from the club moss Lycopodium casuarinoides [1].
|
-
- HY-W203728
-
-
- HY-W585922
-
|
|
Drug Derivative
|
Others
|
|
3β-Cholic acid is a derivative of cholic acid (HY-N0324), and can be found in human feces [1].
|
-
- HY-W127641
-
|
|
Biochemical Assay Reagents
|
Others
|
|
β-Methylcholine Chloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-N13289
-
|
|
Others
|
Cancer
|
|
12β-Hydroxyresibufogenin is a bufadienolide, which shows significant inhibitory activities against cancer cell lines [1].
|
-
- HY-W145659
-
|
Di-beta-D-Xylopyranosylamine
|
Biochemical Assay Reagents
|
Others
|
|
Di(β-D-xylopyranosyl)amine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-N4099R
-
|
|
Others
|
Inflammation/Immunology
|
|
Luteolin-3-O-beta-D-glucuronide (Standard) is the analytical standard of Luteolin-3-O-beta-D-glucuronide. This product is intended for research and analytical applications. Luteolin-3-O-beta-D-glucuronide is a luteolin glucosiduronic acid consisting of luteolin having a beta-D-glucosiduronic acid residue attached at the 3'-position.
|
-
- HY-N3814
-
|
|
Others
|
Inflammation/Immunology
|
|
ent-16β,17-Dihydroxykauran-19-oic acid is an anti-inflammatory agent, which can be isolated from Siegesbeckia pubescens herb. ent-16β,17-Dihydroxykauran-19-oic acid inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglia [1].
|
-
- HY-E70138
-
|
EC:2.4.1.133; B4GALT7
|
Glycosyltransferase
|
Others
|
|
β-1,4-Galactosyltransferase 7 has exclusive specificity for the donor substrate UDP-galactose and all transfer galactose in a β-1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. [1].
|
-
- HY-136542
-
-
- HY-W348476
-
-
- HY-W041992
-
-
- HY-W011445
-
-
- HY-W328332
-
-
- HY-128737
-
-
- HY-151627
-
-
- HY-N9398
-
|
|
Sirtuin
|
Cancer
|
|
3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol, a SIRT1 activator, exhibits significant stimulation of SIRT1 activity. Anti-tumor activity [1].
|
-
- HY-N3825
-
|
|
Apoptosis
|
Cancer
|
|
ent-Kaurane-3α,16β,17-triol (Compound 3) is an anticancer agent. ent-Kaurane-3α,16β,17-triol induces apoptosis in HCT116 cells [1].
|
-
- HY-N0411S1
-
-
- HY-130256
-
|
|
PROTACs
Epigenetic Reader Domain
|
Cancer
|
|
β-NF-JQ1 is a PROTAC that recruits Aryl Hydrocarbon Receptor E3 ligase to target proteins. β-NF-JQ1 is directed against bromodomain-containing (BRD) proteins using β-NF as an AhR ligand, induces the interaction of AhR and BRD proteins, and displays effective anticancer activity that correlated with protein knockdown activity [1].
|
-
- HY-D0886
-
|
|
Phosphatase
Endogenous Metabolite
ERK
|
Metabolic Disease
Cancer
|
|
β-Glycerophosphate disodium salt pentahydrate is a bioactive endogenous metabolite and a phosphatase inhibitor. β-Glycerophosphate disodium salt pentahydrate plays an important role in inducing and maintaining osteoblast differentiation, mineral metabolism and signal transduction, and can be used as a drug carrier to form heat-sensitive hydrogels. β-Glycerophosphate disodium salt hydrate accelerates the calcification of vascular smooth muscle cells [1] .
|
-
- HY-143415
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
Metallo-β-lactamase-IN-7 is a potent VIM-Type metallo-β-lactamase inhibitor with IC50s of 0.019 μM, 13.64 μM, 0.38 μM for VIM-2, VIM-1 and VIM-5. Metallo-β-lactamase-IN-7 potentiate antibacterial activity of Meropenem against the Gram-negative bacterial strains [1].
|
-
- HY-P2289
-
|
pBD-1
|
Bacterial
|
Infection
|
|
β-defesin 1 (pig) (pBD-1) is an endogenous and constitutively expressed antimicrobial peptide (AMP) from porcine tissues, particularly expresses in pig mucosal epithelial sites. β-defesin 1 (pig) has antimicrobial activities and contributes to mucosal and systemic host defenses in pigs [1].
|
-
- HY-N13707
-
|
|
Reactive Oxygen Species
|
Others
|
|
3′-Hydroxytectorigenin-7-O-β-D-xylosyl-(1→6)-β-D-glucopyranoside is an antioxidant that can be found in Pueraria montana var. lobata. It exhibits DPPH radical scavenging activity, with an IC50 value of 42 μg/mL [1].
|
-
- HY-W353102
-
|
|
Endogenous Metabolite
|
Metabolic Disease
Endocrinology
|
|
Estradiol 17-(β-D-Glucuronide), a metabolite of estrogen, is well known to cause intrahepatic cholestasis in humans. Estradiol 17-(β-D-Glucuronide) is a high-affinity substrate for oatp organic anion transporter [1].
|
-
- HY-134426
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
DL-β-Hydroxybutyryl coenzyme A lithium is an intermediate in the fermentation of butyric acid and the metabolism of lysine and tryptophan, and is produced from β-hydroxybutyric acid by short-chain-CoA synthase [1] .
|
-
- HY-N4099
-
|
|
Others
|
Inflammation/Immunology
|
|
Luteolin-3-O-beta-D-glucuronide is a luteolin glucosiduronic acid consisting of luteolin having a beta-D-glucosiduronic acid residue attached at the 3'-position.
|
-
- HY-137236
-
-
- HY-N2760
-
|
|
Others
|
Others
|
|
Sandaracopimaradien-3β-ol is a natural isopimarane-type diterpenoid [1].
|
-
- HY-118774S
-
-
- HY-142598S
-
-
- HY-142266S
-
-
- HY-N3657
-
|
|
Others
|
Others
|
|
Cycloart-23-ene-3β,25-diol is a natural crystalline triterpene [1].
|
-
- HY-132480S
-
-
- HY-B0708
-
-
- HY-12074
-
|
|
GSK-3
|
Metabolic Disease
|
|
Cazpaullone is a glycogen synthase kinase-3 (GSK-3) inhibitor. Cazpaullone can activate pancreatic beta cell protection and replication. Cazpaullone can be used for the research of diabetes [1].
|
-
- HY-W145539
-
|
GlcNAc beta(1-3)[GlcNAc beta(1-6)]GalNAc-alpha-Thr
|
Biochemical Assay Reagents
|
Others
|
|
GlcNAcβ(1-3)[GlcNAcβ(1-6)]GalNAc-α-Thr is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
![GlcNAcβ(1-3)[GlcNAcβ(1-6)]GalNAc-α-Thr](//file.medchemexpress.com/product_pic/hy-w145539.gif)
- HY-P3858
-
|
|
Amyloid-β
|
Neurological Disease
|
|
(D-Asp1)-Amyloid β-Protein (1-42) is a peptide fragment of amyloid β-protein (Aβ). Amyloid β-protein is the primary component of both vascular and parenchymal amyloid deposits in Alzheimer's disease [1].
|
-
- HY-P1548
-
|
Human β-CGRP; CGRP-II (Human)
|
CGRP Receptor
|
Cardiovascular Disease
Inflammation/Immunology
|
|
β-CGRP, human (Human β-CGRP) is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC50s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells [1].
|
-
- HY-141873
-
|
|
Wnt
β-catenin
|
Others
|
|
Wnt/β-catenin agonist 2 is a potent Wnt agonist. Wnt/β-catenin agonist 2 activates Wnt/β-catenin signaling and can be used in the research of diseases related to the signal transduction [1]. (From patent WO2007078113A1, compound 39)
|
-
- HY-108549
-
|
Omuralide; β-Clastolactacystin
|
Proteasome
|
Cancer
|
|
Clasto-Lactacystin β-lactone, a natural active metabolite of lactacystin, which is a metabolite of Streptomyces, acts as an irreversible 20S proteasome inhibitor.
|
-
- HY-N0180
-
-
- HY-W155446
-
|
Decyl 4-O-α-D-glucopyranosyl-1-thio-β-D-glucopyranoside
|
Biochemical Assay Reagents
|
Others
|
|
Decyl beta-d-thiomaltopyranoside (Decyl 4-O-α-D-glucopyranosyl-1-thio-β-D-glucopyranoside) is a biochemical assay reagent.
|
-
- HY-155010
-
|
|
Steroid Sulfatase
|
Metabolic Disease
|
|
Steroid sulfatase/17β-HSD1-IN-5 is a irreversible inhibitor of steroid sulfatase (STS) .Steroid sulfatase/17β-HSD1-IN-5 is a reversible and selective inhibitor of 7β-hydroxysteroid dehydrogenase type1 (17β-HSD1), with IC50s of 43 nM and 6.2μM for 17β-HSD1 and 17β-HSD2, respectively. Steroid sulfatase/17β-HSD1-IN-5 can be used for metabolic disease (especially for endometriosis) research [1].
|
-
- HY-N3824
-
|
|
Others
|
Others
|
|
ent-Atisane-3β,16α,17-triol is a compound that can be isolated from the acetone extract of roots of Euphorbia sieboldiana. ent-Atisane-3β,16α,17-triol is a natural control product [1].
|
-
- HY-157796
-
|
|
Adrenergic Receptor
|
Metabolic Disease
|
|
β2AR agonist 4 (compound A19) is a potent and selective β2-Adrenoceptor agonist with an EC50 of 3.7 pM. β2AR agonist 4 suppresses the inflammatory cytokines and leukocytes upregulation and improves lung function in COPD rat model [1].
|
-
- HY-N15363
-
|
|
Endogenous Metabolite
|
Metabolic Disease
Endocrinology
|
|
5-Pregnene-3β,17a,20a-triol is an endogenous steroid compound. 5-Pregnene-3β,17a,20a-triol plays a role in maintaining the body's hormonal balance. 5-Pregnene-3β,17a,20a-triol is promising for research of congenital steroid synthesis enzyme deficiency diseases [1].
|
-
- HY-W039892
-
|
pNPG_1
|
β-glucuronidase
|
Others
|
|
4-Nitrophenyl β-D-glucuronide (pNPG_1) is aderivative of 4-Nitrophenol. 4-Nitrophenyl β-D-glucuronide is the chromogenic substrate for β-glucuronidase [1].
|
-
- HY-101953
-
|
D'Orenone
|
RAR/RXR
|
Others
|
|
β-Apo-13-carotenone (D'Orenone) is a naturally occurring β-apocarotenoid functioned as an antagonist of RXRα.
|
-
- HY-W142009
-
-
- HY-W561088
-
-
- HY-W587959
-
-
- HY-137426
-
-
- HY-W040202
-
-
- HY-W040166
-
-
- HY-W008866
-
-
- HY-W010924
-
-
- HY-W693175
-
-
- HY-N2212
-
-
- HY-W010888
-
-
- HY-W022446
-
-
- HY-137902
-
-
- HY-W338768
-
-
- HY-W013210
-
-
- HY-W040203
-
-
- HY-137116
-
-
- HY-W013048
-
-
- HY-W011216
-
-
- HY-W142120
-
-
- HY-139138
-
-
- HY-134450
-
-
- HY-W142163
-
-
- HY-134935
-
-
- HY-W015457
-
-
- HY-W015993
-
-
- HY-173494
-
|
|
GSK-3
Casein Kinase
|
Cancer
|
|
GSK-3β/CK-1δ-IN-1 (8d) is a dual and blood-brain barrier penetrated GSK-3β / CK-1δ inhibitor, with IC50 values of 0.77 μM for GSK-3β and 0.57 μM for CK-1δ, respectively. GSK-3β/CK-1δ-IN-1 (8d) can be used in the research for neuroblastoma [1].
|
-
- HY-137522A
-
|
3'-Azido-3'-deoxythymidine β-D-glucuronide
|
Drug Metabolite
|
Others
|
|
Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the major metabolite of Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection [1] .
|
-
- HY-N0768R
-
|
|
Reactive Oxygen Species
|
Inflammation/Immunology
|
|
Quercetin 3-O-β-D-glucofuranoside (Standard) is the analytical standard of Quercetin 3-O-β-D-glucofuranoside. This product is intended for research and analytical applications. Quercetin 3-O-β-D-glucofuranoside is an effective antioxidant and an eosinophilic inflammation suppressor.
|
-
- HY-142128
-
|
Cyclohexyl-hexyl-β-D-maltoside
|
Bacterial
|
Infection
|
|
Cymal-6 (Cyclohexyl-hexyl-β-D-maltoside) is a potent TEM-1 beta-lactamase inhibitor with an Ki value of 40.05 µM. Cymal-6 (Cyclohexyl-hexyl-β-D-maltoside) can be used as glycosidic surfactant [1] .
|
-
- HY-W671745
-
|
|
Others
|
Others
|
|
Entadamide A 2'-O-(6''-O-β-D-glucopyranosyl)-β-D-glucopyranoside (MFLNH I) (compound 5) can be isolated from the seed kernel of Entada rheedei. Entada rheedei is a medicinal plant from Thailand that is used to suppress stomach pain [1].
|
-
- HY-148525
-
|
β2AR/M-receptor agonist-2
|
mAChR
Adrenergic Receptor
|
Cardiovascular Disease
Inflammation/Immunology
|
|
β2AR/M-receptor agonist-2 (compound 15) is a muscarinic antagonist and β2 adrenoceptor agonist (MABA). β2AR/M-receptor agonist-2 shows potency to β2 adrenoceptor with an EC50 value of 3.7 nM. β2AR/M-receptor agonist-2 also has potency to human cloned M3 receptor with a Ki value of 0.73 nM. β2AR/M-receptor agonist-2 is a potent bronchodilator, it can be used for the research of chronic obstructive pulmonary disease (COPD) [1].
|
-
- HY-143614
-
|
|
Thyroid Hormone Receptor
|
Metabolic Disease
|
|
THR-β agonist 3 is a potent agonist of THR-β. THR-β agonist 3 has the potential for the research of metabolic diseases such as obesity, hyperlipidemia, hypercholesterolemia, diabetes and other conditions such as steatosis and non-alcoholic steatohepatitis (NASH), atherosclerosis and other related conditions and diseases (extracted from patent WO2021129827A1, compound 6) [1].
|
-
- HY-43470R
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
3α,12β-Dihydroxycholanoic acid (Standard) is the analytical standard of 3α,12β-Dihydroxycholanoic acid. This product is intended for research and analytical applications. 3α,12β-Dihydroxycholanoic acid is a bile acid that can be isolated from urine specimens of healthy humans[1].
|
-
- HY-157935
-
|
|
Endogenous Metabolite
|
Neurological Disease
|
|
17β-HSD10-IN-3 (compound 23) is a 17β-HSD10 inhibitor with the IC50 of 5.59 μM. 17β-HSD10-IN-3 shows no cell cytotoxicity toward the HEK-293 cell line up to 20 μM [1].
|
-
- HY-143613
-
|
|
Thyroid Hormone Receptor
|
Metabolic Disease
|
|
THR-β agonist 2 is a potent agonist of THR-β. THR-β agonist 2 has the potential for the research of metabolic diseases such as obesity, hyperlipidemia, hypercholesterolemia, diabetes and other conditions such as steatosis and non-alcoholic steatohepatitis (NASH), atherosclerosis and other related conditions and diseases (extracted from patent WO2021121210A1, compound 3) [1].
|
-
- HY-W324220
-
|
|
11β-HSD
|
Metabolic Disease
|
|
11β-HSD1-IN-10 (compound c3a) is a potent 11β-HSD1 inhibitor (IC50=1.8 µM for human). 11β-HSD1-IN-10 can be used in studies of obesity, hyperglycemia and cognitive impairment [1].
|
-
- HY-142917
-
|
|
Thyroid Hormone Receptor
|
Metabolic Disease
|
|
THR-β agonist 4 is a potent agonist of THR-β. THR-β agonist 4 has the potential for the research of metabolic diseases such as obesity, hyperlipidemia, hypercholesterolemia, diabetes and other conditions such as steatosis and non-alcoholic steatohepatitis (NASH), atherosclerosis and other related conditions and diseases (extracted from patent WO2021143706A1, compound 72) [1].
|
-
- HY-N9587
-
|
|
Apoptosis
|
Neurological Disease
|
|
Tricin 7-O-β-D-glucopyranoside is a potent and orally active neuroprotective agent. Tricin 7-O-β-D-glucopyranoside induces Apoptosis. Tricin 7-O-β-D-glucopyranoside decreases the expression of TNF-α induced phosphor-κB-α, phosphor-NF-κB, HMGB1 [1].
|
-
- HY-W290273
-
|
2-Nitrophenyl-beta-D-thiogalactopyranoside
|
Biochemical Assay Reagents
|
Others
|
|
2-Nitrophenyl-β-D-thiogalactopyranoside is a chromogenic substrate used to detect the presence of galactosidase in various biological and biochemical assays.
|
-
- HY-W016083
-
|
β-Naphthoxyethanol
|
Others
|
Others
|
|
Anavenol (β-Naphthoxyethanol) is an agent that can suppress or relieve pain, used for horses [1].
|
-
- HY-N5153
-
|
|
Others
|
Others
|
|
12β-Acetoxyganoderic Acid θ is a triterpenoid that can be isolated from G. lucidum [1].
|
-
- HY-W016424
-
-
- HY-N3534
-
|
Cannabispirol
|
Others
|
Others
|
|
β-Cannabispiranol (Cannabispirol) is a spiro-compound that can be isoalted from Thailand Cannabis [1].
|
-
- HY-148225
-
|
|
Drug Metabolite
|
Cancer
|
|
Fulvestrant 3-β-D-Glucuronide, a metabolite, is glucuronide and sulfate conjugates of Fulvestrant (HY-13636), a pure anti-estrogenic steroid. Fulvestrant 3-β-D-Glucuronide can be used for the research of breast cancer [1].
|
-
- HY-P2999
-
|
ENGase
|
Endogenous Metabolite
|
Others
|
|
Endo-β-N-acetylglucosaminidase (ENGase) is cytosolic deglycosylating enzyme that hydrolyzes the N-linked oligosaccharides. Endo-β-N-acetylglucosaminidase can be used for glycan analysis on glycoproteins and preparation of precursors for glycosylated compounds, is often used in biochemical studies [1].
|
-
- HY-107271
-
|
|
Others
|
Cancer
|
|
Imperialine 3-β-D-glucoside is the glycoside of Imperialine (HY-N0696). Imperialine 3-β-D-glucoside may exhibit anti-tumor properties against multi-agent resistant tumor cells [1].
|
-
- HY-N2100
-
|
|
Reactive Oxygen Species
|
Metabolic Disease
|
|
6'-O-beta-D-Glucosylgentiopicroside is a secoiridoid isolated from the roots of G. straminea. 6'-O-beta-D-Glucosylgentiopicroside strongly suppresses N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide generation [1].
|
-
- HY-P1866A
-
|
|
Opioid Receptor
|
Neurological Disease
|
|
β-Endorphin, equine TFA is an endogenous opioid peptide, which binds at high affinity to both μ/δ opioid receptors. β-Endorphin, equine TFA has analgesic properties [1] .
|
-
- HY-P2866
-
|
|
Endogenous Metabolite
|
Others
|
|
β-N-Acetylhexosaminidase (EC 3.2.1.52) is an exoglycosidase that catalyzes the hydrolysis of terminal non-reducing β-N-acetylgalactosamine and glucosamine residues in oligosaccharides for epigenetic applications [1].
|
-
- HY-158210
-
|
|
Wnt
β-catenin
MDM-2/p53
|
Cancer
|
|
Wnt/β-catenin-IN-3 (compound 17) is a Wnt/β-catenin inhibitor with low micromolarGI50s against various cancer cells. Wnt/β-catenin-IN-3triggers G2/M cell cycle arrest though activation of p53-p21 pathway as well as intrinsic and extrinsic apoptotic death of colon cancer cells [1].
|
-
- HY-146165
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
Metallo-β-lactamase-IN-8 (compound 17) is a potent, reversible and competitive broad-spectrum inhibitor of metallo-β-lactamases (MβLs), with IC50s of 1.3 μM, 5.7 μM, 9.8 μM, and 9.9 μM for L1, ImiS, IMP-1 and VIM-2, respectively. Metallo-β-lactamase-IN-8 exhibits antibacterial activity [1].
|
-
- HY-W416254
-
|
|
Biochemical Assay Reagents
|
Others
|
|
4-Nitrophenyl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology [1].
|
-
- HY-N6879R
-
|
|
Others
|
Metabolic Disease
|
|
DiosMetin 7-O-β-D-Glucuronide (Standard) is the analytical standard of DiosMetin 7-O-β-D-Glucuronide. This product is intended for research and analytical applications. DiosMetin 7-O-β-D-Glucuronide is an antioxidant constituent in the fruits of Luffa cylindrical [1].
|
-
- HY-N4088R
-
|
|
Fungal
|
Infection
Endocrinology
|
|
Pseudolaric acid A-O-β-D-glucopyranoside (Standard) is the analytical standard of Pseudolaric acid A-O-β-D-glucopyranoside. This product is intended for research and analytical applications. Pseudolaric acid A-O-β-D-glucopyranoside, isolated from Cortex Pseudolaricis, demonstrates antifungal and antifertility activities [1].
|
-
- HY-124265
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
4β-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation [1].
|
-
- HY-W701984
-
|
|
Glucocorticoid Receptor
|
Endocrinology
|
|
11β-Hydroxyetiocholanolone is a metabolite of Hydrocortisone (HY-N0583). Hydrocortisone is a steroid hormone or glucocorticoid secreted by the adrenal cortex.
|
-
- HY-E70285
-
|
B4GALT1 (Y285L)
|
Endogenous Metabolite
|
Metabolic Disease
|
|
beta-1,4-Galactosyltransferase 1 (Y285L) can enzymatic synthesis of the LacdiNAc motif. beta-1,4-Galactosyltransferase 1 (Y285L) can transfer of GalNAc from UDP-GalNAc [1].
|
-
- HY-114321
-
|
|
Wnt
|
Cancer
|
|
Wnt/β-catenin agonist 1 (compound 3f) is a Wnt/β-catenin signalling pathway agonist, with an EC50 of 0.27 μM [1].
|
-
- HY-N13510
-
|
|
Others
|
Others
|
|
(19R,23S)-5β,19-Epoxy-19,23-dimethoxycucurbita-6,24-dien-3β-ol is a triterpenoid product that can be isolated from Momordica charantia [1].
|
-
- HY-N13492
-
|
|
Others
|
Others
|
|
(19R,23E)-5β,19-Epoxy-19-methoxycucurbita-6,23,25-trien-3β-ol is a Triterpene product that can be isolated from Momordica charantia [1].
|
-
- HY-148526
-
|
|
Adrenergic Receptor
mAChR
|
Metabolic Disease
|
|
β2AR/M3-receptor agonist-1 (example 9) is a potent β2AR and M3 receptor agonist. β2AR/M3-receptor agonist-1 shows M3 receptor affinity with a pIC50 value of 9.3. β2AR/M3-receptor agonist-1 has the potential for the research of respiratory tract disorders [1].
|
-
- HY-162659
-
|
|
Adrenergic Receptor
|
Others
|
|
β2AR ligand 1 (Compound 4) is a homobivalent bitopic ligand for β2 adrenergic receptor (β2AR) on the orthosteric binding site (OBS) and the metastable binding sites (MBS) [1].
|
-
- HY-113949A
-
|
|
Drug Isomer
|
Others
|
|
Methyl 2,3-O-Isopropylidene-β-L-ribofuranoside is an enantiomer of Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside. Methyl 2,3-O-Isopropylidene-β-L-ribofuranoside is a derivative of L-ribose [1].
|
-
- HY-W250154
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
β-Nicotinamide adenine dinucleotide reduced dipotassium is an orally active reduced coenzyme. β-Nicotinamide adenine dinucleotide reduced dipotassium is a donor of ADP-ribose units in ADP-ribosylaton reactions and a precursor of cyclic ADP-ribose. β-Nicotinamide adenine dinucleotide reduced dipotassium plays a role as a regenerative electron donor in cellular energy metabolism, including glycolysis, β-oxidation and the tricarboxylic acid (TCA) cycle [1].
|
-
- HY-W293502
-
|
2-Chloro-4-nitrophenyl-beta-D-galactopyranoside
|
Biochemical Assay Reagents
|
Others
|
|
2-Chloro-4-nitrophenyl-β-D-galactopyranoside is a chromogenic substrate used for testing enzyme activity. It is commonly used in molecular biology research to detect and measure the activity of β-galactosidase (biosynth: EC03318).
|
-
- HY-P990140
-
|
|
MHC
|
Others
|
|
Anti-Rat β-2-Microglobulin Antibody (4C9) is a mouse-derived IgG1 type antibody inhibitor, targeting to rat β-2-Microglobulin.
|
-
- HY-N13701
-
|
|
NO Synthase
|
Inflammation/Immunology
|
|
3β,7β,15α-Trihydroxy-4-(hydroxymethyl)-11,23-dioxo-lanost-8-en-26-oic acid is a triterpene compound that can be found in Ganoderma lucidum, and it inhibits nitric oxide (NO) production in BV-2 microglial cells induced by lipopolysaccharide (LPS, HY-D1056), with an IC50 of 4.15 μM [1].
|
-
- HY-152105
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
Metallo-β-lactamase-IN-9 (Compound 23) is a pan metallo-beta-lactamase (MBL) inhibitor with IC50s of 35, 269 and 369 nM against NDM-1, VIM-1 and IMP-1, respectively [1].
|
-
- HY-147342
-
|
|
DNA/RNA Synthesis
|
Others
|
|
β-Benzamide adenine dinucleotide is a bioactive metabolite of benzamide nucleoside and a potent inhibitor of inosine 5 '-monophosphate dehydrogenase (IMPDH). β-Benzamide adenine dinucleotide is a potent, competitive inhibitor of human NAD kinase (Ki = 90 µM) [1] .
|
-
- HY-P5892
-
|
|
Opioid Receptor
|
Neurological Disease
|
|
β-Endorphin (1-27) (human) is an opioid antagonist that binds μ-, δ-, and κ-opioid receptors with Kis of 5.31, 6.17, and 39.82 nM, respectively. β-Endorphin (1-27) (human) inhibits β-Endorphin (HY-P1502)-induced and etorphine-induced analgesia [1] .
|
-
- HY-N7683
-
|
|
Glycosidase
|
Metabolic Disease
|
|
Prunetin 5-O-β-D-glucopyranoside is an isoflavone isolated from extracts of Potentilla astracanica. Prunetin 5-O-β-D-glucopyranoside is a potent and uncompetitive inhibitor of α-glucosidase, with an IC50 of 56.05 μg/mL. Prunetin 5-O-β-D-glucopyranoside can be used for the research of type-2 diabetes [1].
|
-
- HY-W854392
-
|
|
Biochemical Assay Reagents
|
|
|
3-Carboxyumbelliferyl-β-D-glucuronide (dipotassium) is a chromogenic substrate with biological activity for enzyme activity detection. 3-Carboxyumbelliferyl-β-D-glucuronide (dipotassium) can be used to evaluate biological reactions associated with glycosidases. 3-Carboxyumbelliferyl-β-D-glucuronide (dipotassium) shows a wide range of application potentials in compound discovery and biomedical research.
|
-
- HY-N12123
-
|
|
Others
|
Others
|
|
Peimisine 3-O-β-D-glucopyranoside (Compound 1) is a steroid alkaloid. Peimisine 3-O-β-D-glucopyranoside can be isolated and purified from natural Fritillaria unibracteata. Peimisine 3-O-β-D-glucopyranoside shows moderate protective effect on rotenone-induced neurotoxicity of PC12 cell line [1].
|
-
- HY-106288
-
|
|
PTHR
|
Cancer
|
|
Human PTHrP-(1-36) is a secretory form of PTHrP with anticalciuric effects. Human PTHrP-(1-36) enhances beta cell function and proliferation. Human PTHrP-(1-36) can be used in the research of humoral hypercalcemia of malignancy (HHM) and hyperparathyroidism [1] .
|
-
- HY-150977
-
-
- HY-150976
-
-
- HY-P3831
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
β-Interleukin II (44-56) is a 44-56 fragment of beta-interleukin II polypeptide. Interleukin family are a group of cytokines associated with immune system, mainly expressed by leukocytes [1].
|
-
- HY-N12997
-
|
|
Others
|
Others
|
|
Torachrysone 8-O-β-D-glucoside is a phenolic glycoside that can be isolated from the seeds of Senna tora. Torachrysone 8-O-β-D-glucoside shows cytotoxicity [1].
|
-
- HY-N12245
-
|
|
Others
|
Cancer
|
|
Narciclasine-4-O-β-D-glucopyranoside can be isolated from Pancratium maritimum. Narciclasine-4-O-β-D-glucopyranoside has anticancer activity [1].
|
-
- HY-N2831
-
|
|
Others
|
Others
|
|
Agrimonolide 6-O-β-D-glucoside is a isocoumarin that can be isolated from Agrimonia pilosa. Agrimonolide 6-O-β-D-glucoside is used in hepatic disease research [1].
|
-
- HY-W013854
-
|
3β-Hydroxy-5α-androstane
|
Endogenous Metabolite
|
Others
|
|
5α-Androstan-3β-ol (Androstan), a saturated sterol, is a CAR (constitutive androstane receptor) inverse agonist ligand. 5α-Androstan-3β-ol (Androstan) increases the AmB-channel conductance in a concentration dependent manner [1] .
|
-
- HY-N9525
-
|
|
Others
|
Others
|
|
Limocitrin 3-β-D-glucose is a flavonoid glycoside [1].
|
-
- HY-N13309
-
|
|
Others
|
Others
|
|
Torosachrysone 8-O-beta-gentiobioside is a natural product [1].
|
-
- HY-W039931
-
-
- HY-W008741
-
-
- HY-W339410
-
-
- HY-N8021
-
|
(+)-Epipinoresinol-4′′-β-D-glucoside
|
Others
|
Others
|
|
Epipinoresinol-4-O-β-glucoside (Compound 3) is a lignan glucoside that can be isolated from Forsythia suspensa [1].
|
-
- HY-P1589
-
|
|
β-catenin
|
Cancer
|
|
β-catenin peptide is a 8-aa peptide, and can promote thymocyte positive selection.
|
-
- HY-N11016
-
|
|
Others
|
Others
|
|
1-Methoxymethyl-β-carboline is a natural product isolated from the root of Eurycoma longifolia [1].
|
-
- HY-160790
-
|
|
ADC Linker
|
Cancer
|
|
β-Glu-PNP is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].
|
-
- HY-W699936
-
|
|
Cytochrome P450
|
Others
|
|
6β-Hydroxy androstenedione is a steroid product that can be isolated from Fusarium culmorum [1].
|
-
- HY-N2075
-
-
- HY-N3358
-
|
|
Others
|
Others
|
|
Lupeol β-hydroxyoctadecanoate is a Triterpenoids product that can be isolated from the roots of Biondia hemsleyana. [1].
|
-
- HY-113019S
-
-
- HY-N5108
-
|
|
Others
|
Others
|
|
4β,12-Dihydroxyguaian-6,10-diene, a natural terpene, is isolated from the rhizomes of Alisma orientale [1].
|
-
- HY-163779
-
|
|
Glycosidase
|
Neurological Disease
|
|
β-Glucocerebrosidase modulator 1 (Compound 28) is an allosteric modulator for β-Glucocerebrosidase with an EC50 of 9.0 μM and a Kd of 0.050 μM [1].
|
-
- HY-N8555
-
|
|
Others
|
Others
|
|
ent-Kaurane-16β,19,20-triol is a Diterpenoids product that can be isolated from the herbs of Euphorbia ehracteolata [1].
|
-
- HY-P1363F3
-
|
5-FAM-Amyloid β-peptide (1-42) (human) Tris
|
Amyloid-β
|
Neurological Disease
|
|
5-FAM-β-Amyloid (1-42), human (5-FAM-Amyloid β-peptide (1-42) (human) TFA is a5-FAM labeled β-Amyloid (1-42), human TFA (HY-P1363).
|
-
- HY-160497
-
|
|
PROTAC-Linker Conjugates for PAC
|
Cancer
|
|
MC-(β-Ala)-PABC-(β-D-GlcUA)-amide-PEG1-CH2-CC-885 (Comp Ie) is a neodegrader conjugate, can be used in the synthesis of antibody neoDegrader conjugate (AnDC) [1].
|
-
- HY-133709
-
|
|
Parasite
|
Infection
|
|
β-Aflatrem is an insecticide metabolite from the sclerotium of Aspergillus flavus that exhibits significant activity against the corn borer H. zea [1].
|
-
- HY-N8805
-
|
|
Others
|
Cancer
|
|
Nortrachelogenin-8'-O-β-glucoside is a natural product that can be isolated from the dried roots of Pulsatilla koreana. Nortrachelogenin-8'-O-β-glucoside inhibits cancer cell proliferation and reduces hormone dependence [1] .
|
-
- HY-N12067
-
|
|
Others
|
Inflammation/Immunology
|
|
Columbianetin β-D-glucopyranoside can be isolated from Angelicae pubescentis radix and has antiplatelet aggregation, anti-inflammatory and analgesic activities. Columbianetin β-D-glucopyranoside exerts significant protective effects against glutamate-induced toxicity [1].
|
-
- HY-N1661
-
|
|
Others
|
Others
|
|
2α,3β-Dihydroxypterodontic acid is a natural product used for synthesize 2α,3β-dihydroxy-5,11(13)-dien-eudesman-12-oic acid [1].
|
-
- HY-W416278
-
|
Pentyl 2-acetamido-2-deoxy-β-D-glucopyranoside
|
Biochemical Assay Reagents
|
Others
|
|
Pentyl 2-(acetylamino)-2-deoxy-β-D-glucopyranoside (Pentyl 2-acetamido-2-deoxy-β-D-glucopyranoside) is used in glycobiology research.
|
-
- HY-N2142
-
|
|
Others
|
Cancer
|
|
3-O-beta-Allopyranosyl-(1->4)-beta-oleandropyranosyl-11-O-isobutyryl-12-O-acetyltenacigenin B is a chemical constituent of the plant Poria cocos [1].
|
-
- HY-137522S
-
|
3'-Azido-3'-deoxythymidine β-D-glucuronide-d3 sodium
|
Isotope-Labeled Compounds
Drug Metabolite
|
Others
|
|
Zidovudine O-β-D-glucuronide-d3 (sodium) (3'-Azido-3'-deoxythymidine β-D-glucuronide-d3 (sodium)) is a deuterium labeled Zidovudine O-β-D-glucuronide (sodium) (HY-137522). Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the major metabolite of Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection [1] .
|
-
- HY-P1548B
-
|
Human β-CGRP acetate; CGRP-II (Human) (acetate)
|
CGRP Receptor
|
Cardiovascular Disease
Inflammation/Immunology
|
|
β-CGRP, human acetate (Human β-CGRP acetate) is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC50s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells [1].
|
-
- HY-N10741
-
|
|
Xanthine Oxidase
Bacterial
|
Infection
|
|
Ellagic acid 4-O-β-D-xylopyranoside is a natural ellagitannin with antimicrobial activity. Ellagic acid 4-O-β-D-xylopyranoside is an xanthine oxidase inhibitor with an 50 of 2.1 μg/mL [1].
|
-
- HY-N7755
-
|
|
Estrogen Receptor/ERR
|
Cancer
|
|
Estradiol 3-(β-D-Glucuronide) sodium is the glucuronic acid derivative of estradiol (HY-B0141). Estradiol 3-(β-D-Glucuronide) sodium is radiolabeled for use in tumor imaging and biodistribution studies [1].
|
-
- HY-128974
-
|
Lauryl Maltoside
|
DNA/RNA Synthesis
|
Others
|
|
N-Dodecyl-β-D-maltoside (Lauryl Maltoside) is a non-ionic detergent. N-Dodecyl-β-D-maltoside has strong adsorption on alumina, titanium dioxide and hematite. N-Dodecyl-β-D-maltoside can promote the reactivation of various proteins. N-Dodecyl-β-D-maltoside can effectively stabilize photoactive reaction center complexes (RCs) and inhibit the degradation of Rhodopseudomonas spheroides R-26 reaction center in solution. N-Dodecyl-β-D-maltoside can be used for purification and stabilization of RNA polymerase and for detection of protein-lipid interactions [1] .
|
-
- HY-N10587
-
|
|
Others
|
Inflammation/Immunology
|
|
Catechin 7-O-beta-D-glucopyranoside is an orally active natural product found in Ulmus davidiana and Paeonia obovata. Catechin 7-O-β-D-glucopyranoside shows antioxidant and anti-inflammatory activities, and attenuates mitochondrial dysfunction. Catechin 7-O-beta-D-glucopyranoside can be used in intestinal inflammatory disease research [1] .
|
-
- HY-N3661
-
|
|
Bacterial
|
Infection
|
|
(24S)-Cycloartane-3β,24,25-triol, a cycloartane, has antitubercular activity against Mycobacterium tuberculosis H37Rv (MIC: 32 μg/mL). (24S)-Cycloartane-3β,24,25-triol can be isolated from the flowers of Chrysanthemum morifolium [1].
|
-
- HY-P4882
-
|
|
Amyloid-β
|
Neurological Disease
|
|
(Pyr3)-Amyloid β-Protein (3-42) is the predominant amyloid β-peptide structure deposited in human brain of Alzheimer's disease and Down's syndrome patients. (Pyr3)-Amyloid β-Protein (3-42) is suggested to accumulate in the brain and to trigger the formation of insoluble amyloid β-peptide deposits [1].
|
-
- HY-163363
-
|
|
Adrenergic Receptor
|
Cancer
|
|
β-AR antagonist 2 (compound 43) is an antagonist of β-AR (IC50: 0.17 μM). β-AR-IN-1 inhibits the growth of mouse A549 xenograft tumors and shows cardioprotective efficacy against DOX-induced HF in C57 mice [1].
|
-
- HY-P2550
-
|
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (1-40), FAM-labeled is a FAM fluorescently-labelled β-Amyloid (1-40) peptide (λex= 492 nm and λem= 518 nm) [1].
|
-
- HY-126107
-
-
- HY-N1905
-
|
|
Others
|
Others
|
|
4-Methoxy-β-carboline-1-carboxylic acid methylester is an alkaloid with the structure of canthin-6-one and β-carboline [1].
|
-
- HY-W142692
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Dodecyl β-D-glucopyranoside is a non-ionic detergent and surfactant commonly used to solubilize and purify membrane proteins in biochemical research. Dodecyl β-D-glucopyranoside also interacts with bovine serum albumin (BSA) to quench its intrinsic fluorescence. The critical micelle concentration (CMC) of Dodecyl β-D-glucopyranoside (DG) and DG/BSA complex is 2.0 mM and 2.34 mM, respectively. Micelles can be formed in aqueous solutions above this concentration [1].
|
-
- HY-W559353
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
1-(3-Beta-amino-2,3-dideoxy-beta-d-threopenta-furanosyl)thymine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc [1].
|
-
- HY-P1363
-
|
Amyloid β-peptide (1-42) (human) TFA
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (1-42), human TFA (Amyloid β-Peptide (1-42) (human) TFA) is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease [1] .
|
-
- HY-N0520R
-
|
|
Reactive Oxygen Species
|
Others
|
|
Calycosin-7-O-β-D-glucoside (Standard) is the analytical standard of Calycosin-7-O-β-D-glucoside. This product is intended for research and analytical applications. Calycosin-7-O-β-D-glucoside is an isoflavone isolated from Astragali Radix. Calycosin-7-O-β-D-glucoside has variety of biological activities, such as neuroprotective, cardioprotection, anti-inflammation, and antioxidative stress effects [1] .
|
-
- HY-W357152
-
-
- HY-N8143
-
-
- HY-N13348
-
|
|
Others
|
Others
|
|
Emodin-8-O-beta-gentiobioside is a natural product [1].
|
-
- HY-W014505
-
-
- HY-W274569
-
-
- HY-N13419
-
|
|
Others
|
Others
|
|
3β-Isodihydrocadambine 4-oxide is a natural product [1].
|
-
- HY-137232
-
-
- HY-N7559
-
|
|
Others
|
Others
|
|
7β-Acetoxytaxuspine C is a Diterpenoids product that can be isolated from the needles of Taxus canadensis. [1].
|
-
- HY-137197
-
-
- HY-N9201
-
|
|
Others
|
Others
|
|
8beta-Methoxyatractylenolide I is a Sesquiterpenoids product that can be isolated from the rhizomes of Atractylodes macrocephala. [1].
|
-
- HY-N2820
-
|
|
Others
|
Others
|
|
Adynerigenin beta-neritrioside is a Steroids product that can be isolated from the herbs of Nerium indicum Mill. [1].
|
-
- HY-137919
-
-
- HY-138322
-
|
|
ADC Linker
|
Cancer
|
|
N-trifluoroacetyl-β-alanyl chloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].
|
-
- HY-137940
-
|
Gentiobiose
|
Others
|
Others
|
|
β-Gentiobiose (Gentiobiose) is a naturally occurring oligosaccharin with a rapid turnover rate in ripening tomato fruit [1].
|
-
- HY-W114954
-
|
|
Bacterial
|
Inflammation/Immunology
|
|
Guaiacylglycerol-beta-guaiacyl ether is a model compound of lignin monomers that can be degraded by Bacillus amyloliquefaciens CotA [1].
|
-
- HY-N12034
-
|
|
Others
|
Others
|
|
Picropodophyllin-β-D-glucoside (compound 3) is a podophyllotoxin glucoside isolated from Chinese medicinal plants [1].
|
-
- HY-W756134
-
|
|
Isotope-Labeled Compounds
Drug Metabolite
FXR
|
Metabolic Disease
|
|
Chenodeoxycholic acid 24-acyl-β-D-glucuronide-d5 sodium is the deuterium labeled Chenodeoxycholic acid 24-acyl-β-D-glucuronide sodium. Chenodeoxycholic acid 24-acyl-β-D-glucuronide sodium is a metabolite of Chenodeoxycholic Acid (HY-76847) [1].
|
-
- HY-48959
-
|
|
Integrin
|
Metabolic Disease
|
|
α7β1 integrin modulator-1 is a potent α7β1 integrin modulator. α7β1 integrin modulator-1 has the potential for the research of muscular dystrophy [1].
|
-
- HY-N2929
-
|
|
Glycosidase
|
Cardiovascular Disease
|
|
β-Hydroxypropiovanillone, a natural compound, shows significant concentration-dependent inhibitory effects on α-glucosidase with an IC50 of 257.8 μg/mL [1].
|
-
- HY-N1616
-
|
|
Apoptosis
|
Others
|
|
1β-Hydroxyeuscaphic acid has significant hepatoprotective activity by lowering the leakage of intracellular enzymes, reducing the oxidation of proteins and decreasing the incidence of apoptosis [1].
|
-
- HY-P5124
-
|
KLVFF
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid peptide(16-20) is a amino acid sequences (KLVFF) of Amyloid-β (Abeta). β-Amyloid peptide(16-20) is an effective inhibitor of Abeta fibril formation, with RG-/-GR-NH2 residues added at N- and C-terminal ends to aid solubility) [1].
|
-
- HY-169238
-
|
|
17β-HSD
|
Metabolic Disease
|
|
17β-HSD7-IN-1 (compound 4) is an inhibitor of 17β-HSD7, with inhibitory effect agasint the formation of Estradiol (IC50=63 nM). [1].
|
-
- HY-N8102
-
|
|
Transmembrane Glycoprotein
Others
|
Cardiovascular Disease
|
|
Echinocystic acid 28-O-β-D-glucoside is a metabolite of Echinocystic acid by microbial oxidation and glucosidation. Echinocystic acid 28-O-β-D-glucoside is a tissue factor pathway inhibitor, with an IC50 of 10.61 nM [1].
|
-
- HY-P2283
-
|
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (1-37) (human) correlates moderately with Mini-Mental State Examination (MMSE) scores in Alzheimer disease. β-Amyloid (1-37) (human) possesses an added diagnostic value [1].
|
-
- HY-132382S
-
-
- HY-16673
-
|
|
GPR119
|
Metabolic Disease
|
|
PSN632408, a selective, orally active GPR119 agonist, shows similar potency to OEA at both recombinant mouse and human GPR119 receptors (EC50=5.6 and 7.9 uM, respectively). PSN632408 can stimulate β-cell replication and improve islet graft function. PSN632408 has the potential for the research of obesity and related metabolic disorders [1] .
|
-
- HY-P3859
-
|
|
Amyloid-β
|
Neurological Disease
|
|
Cys-Gly-Lys-Arg-Amyloid β-Protein (1-42) is a peptide fragment of amyloid β-protein (Aβ). Cys-Gly-Lys-Arg-Amyloid β-Protein (1-42) can be used in research of Alzheimer's disease [1].
|
-
- HY-N4201
-
|
|
EGFR
Src
|
Cancer
|
|
Beta-hydroxyisovalerylshikonin is a natural product isolated from Lithospermum erythrorhizon, acts as a potent inhibitor of protein tyrosine kinases (PTK), with IC50s of 0.7μM and 1μM for EGFR and v-Src receptor, respectively. Beta-hydroxyisovalerylshikonin is effective against a wide variety of tumor cell lines, and most efficiently induces cell-death in NCI-H522 and DMS114 cells [1].
|
-
- HY-139413
-
|
|
Toll-like Receptor (TLR)
|
Cancer
|
|
β-D-glucan is a natural non-digestible polysaccharide and high biocompatibility that can be selectively recognized by recognition receptors such as Dectin-1 and Toll-like receptors as well as being easily internalized by murine or human macrophages, which is likely to attribute to a target delivery [1]. β-d-glucan is an enteric delivery vehicle for probiotics .
|
-
- HY-N12978
-
|
|
Others
|
Cancer
|
|
Benzyl β-gentiobioside is a phenyl alcohol glycoside found in peach kernels (Prunus persica seeds). Benzyl β-gentiobioside has anti-tumor promoting activity by inhibiting TPA (12-O-tetradecanoylphorbol 13-acetate, a tumor promoter)-induced Epstein-Barr virus early antigen (EBV-EA) activation [1].
|
-
- HY-N7598
-
|
|
Monoamine Oxidase
|
Neurological Disease
|
|
Chrysophanol-1-O-β-gentiobioside, an anthraquinone glycoside isolated from Cassia obtusifolia seeds. Chrysophanol-1-O-β-gentiobioside shows selective inhibition of hMAO-A isozyme activity (IC50=96.15 μM) [1].
|
-
- HY-W587861
-
|
5βDHP
|
Oxytocin Receptor
|
Endocrinology
|
|
5β-Dihydroprogesterone (5βDHP) is the metabolite of Progesterone (HY-N0437). 5β-Dihydroprogesterone binds to oxytocin receptor, reduces the Oxytocin (HY-17571)-induced calcium signal transduction, thereby exhibiting the tocolytic activity [1].
|
-
- HY-142441
-
|
|
Thyroid Hormone Receptor
|
Endocrinology
|
|
THR-β Agonist 1 is a potent and selective agonist of THRβ. Thyroid hormone receptor mediates the physiological activity of thyroid hormones which plays a key role in normal growth and development of the body and in maintaining metabolic balance. THR-β Agonist 1 has the potential for the research of thyroid hormone receptor-related diseases (extracted from patent WO2021104288A1, compound 2) [1].
|
-
- HY-N0171A
-
-
- HY-D1224A
-
|
CPRG
|
Biochemical Assay Reagents
|
Others
|
|
Chlorophenol red-β-D-galactopyranoside sodium is a long-wavelength dye, which has been widely used for colorimetric assays. Chlorophenol red-β-D-galactopyranoside sodium is also a β-D-Galactosidase (HY-P2869I) substrate commonly used in recombinant yeast oestrogenic assays [1] .
|
-
- HY-168130
-
|
|
TNF Receptor
Interleukin Related
|
Cardiovascular Disease
|
|
TNF-α/IL-1β-IN-1 (compund 11a) is an anti-inflammatory agent that reduces the expression of TNF-α and IL-1β, inhibits oxidative stress and cardiomyocyte apoptosis, has good activity against septic myocardial injury, and improves myocardial blood supply in vivo [1].
|
-
- HY-N2182R
-
|
|
Others
|
Inflammation/Immunology
|
|
Episyringaresinol 4'-O-β-D-glncopyranoside (Standard) is the analytical standard of Episyringaresinol 4'-O-β-D-glncopyranoside. This product is intended for research and analytical applications. Episyringaresinol 4'-O-β-D-glncopyranoside (compound 22), isolated from Alhagi sparsifolia Shap, is a natural potential neuroinflammatory inhibitor [1].
|
-
- HY-E70139
-
|
EC:2.4.1.313; B3GALNT2; β-1,3-N-acetylgalactosaminyltransferase II
|
Glucosylceramide Synthase (GCS)
|
Others
|
|
UDP-GalNAc:β-1,3-N-acetylgalactosaminyltransferase 2 ( EC:2.4.1.313; B3GALNT2; β-1,3-N-acetylgalactosaminyltransferase II) is a glycosyltransferase
[1].
|
-
- HY-B0141S
-
|
β-Estradiol-d3; 17β-Estradiol-d3; 17β-Oestradiol-d3
|
Estrogen Receptor/ERR
Endogenous Metabolite
|
Endocrinology
Cancer
|
|
Estradiol-d3 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.
|
-
- HY-149727
-
|
|
Adrenergic Receptor
|
Metabolic Disease
|
|
β2AR agonist 2(compound 8a) is a β2 -Adrenergic receptor (β2AR) agonist. β2AR agonist 2 is a saturated nitrogen ring compound containing 4- to 7-membered heterocycle. β2AR agonist 2 has a chiral structure (the -R form) by carrying carbon containing the essential hydroxyl, thereby enhancing cellular glucose uptake (GU) activity and significantly stimulating glucose uptake by skeletal muscle cells. β2AR agonist 2 can be used in the study of Type 2 Diabetes (T2D) [1].
|
-
- HY-P1363B
-
|
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (1-42), human, HFIP-treated is a β-Amyloid (1-42), human (HY-P1363A) treated with HFIP. β-Amyloid (1-42), human (Amyloid β-Peptide (1-42) (human)) is a 42-amino acid peptide that causes neurotoxicity, which is related to the pathogenesis of Alzheimer's disease. β-Amyloid (1-42), human specifically interacts with the promoters of genes like LRP1 and KAI1. β-Amyloid (1-42), human can form oligomers and fibrils in vitro, and the oligomeric form is more neurotoxic than the fibrillar form [1] .
|
-
- HY-W250196
-
|
Nonyl-beta-D-1-thiomaltoside
|
Biochemical Assay Reagents
|
Others
|
|
Nonyl-β-D-1-thiomaltoside is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-N6677
-
|
Apocarotenal
|
Cytochrome P450
|
Cancer
|
|
β-Apo-8'-carotenal (Apocarotenal), a provitamin A carotenoid, is an inducer of CYPlA1 and CYPlA2 in rat. β-Apo-8'-carotenal is present in many fruits and vegetables [1].
|
-
- HY-155379
-
|
|
Virus Protease
|
Infection
|
|
β-Herpesvirus protease-IN-1 (compound 19) is a β-herpesvirus protease inhibitor with IC50s of 2.5 μM and 0.33 μM for HCMVPro and HHV6Pro, respectively [1].
|
-
- HY-N1111
-
|
6β,19α-Dihydroxyursolic acid
|
HIV
|
Infection
|
|
Uncaric acid (6β,19α-Dihydroxyursolic acid) (compound 6) is a triterpene that can be found in Eriobotrya japonica. Uncaric acid shows anti HIV-1, HRV 1B, SNV activity [1].
|
-
- HY-137845
-
|
|
Fluorescent Dye
|
Others
|
|
4-Methylumbelliferyl β-D-galactopyranoside is a fluorescent substrate for β-galactosidase which, when cleaved, produces a water-soluble blue fluorescent coumarin fluorophore that can be detected using a fluoroenzymeter or fluorometer [1].
|
-
- HY-N12078
-
|
|
Biochemical Assay Reagents
|
Cancer
|
|
4-Chloro-3-methoxy-5-methylphenyl 6-O-(6-deoxy-β-L-mannopyranosyl)-β-D-glucopyranoside (compound 3) is an anticancer agent and natural product that can effectively inhibit lung cancer proliferation of A549 cells. 4-Chloro-3-methoxy-5-methylphenyl 6-O-(6-deoxy-β-L-mannopyranosyl)-β-D-glucopyranoside is available from Lilium regale and has potential for use in cancer research [1].
|
-
- HY-151260
-
|
|
Beta-secretase
Cholinesterase (ChE)
GSK-3
|
Neurological Disease
|
|
AChE/BACE1/GSK3β-IN-1 is an orally active triple inhibitor of AChE/BACE1/GSK3β. AChE/BACE1/GSK3β-IN-1 has effective inhibitory activity against AChE, BACE1 and GSK3β with IC50 values of 1.0 μM, 20 μM and 15 μM, respectively. AChE/BACE1/GSK3β-IN-1 has good blood-brain barrier penetrability, suitable bioavailability. AChE/BACE1/GSK3β-IN-1 can be used for the research of Alzheimer's disease (AD) [1].
|
-
- HY-P5945
-
-
- HY-144259
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
Metallo-β-lactamase-IN-4 (compound 40) is a potent metallo-β-lactamases (MBL) inhibitor, with IC50 values of 0.1 μM (VIM-1), 1.3 μM (NDM-1), and 5.0 μM (IMP-7), respectively [1].
|
-
- HY-N0097A
-
|
AraG
|
Drug Derivative
|
Cancer
|
|
9-β-D-Arabinofuranosylguanine is a Guanosine (HY-N0097) analog and shows high affinity for deoxyguanosine kinase (dGK) with a Km of 8.0 μM. 9-β-D-Arabinofuranosylguanine can be used for the research of T-cell lymphoblastic disease [1] .
|
-
- HY-W020795
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Hexadecyl β-D-maltoside is the anomer of Hexadecyl α-d-maltoside. Hexadecyl β-D-maltoside is different from Hexadecyl α-d-maltoside, showing non-Newtonian behavior, including thixotropic behavior, shear-thinning, and viscoelastic behavior [1].
|
-
- HY-144262
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
Metallo-β-lactamase-IN-4 (compound 40) is a potent metallo-β-lactamases (MBL) inhibitor, with IC50 values of 0.5 μM (VIM-1), 2.1 μM (NDM-1), and 3.3 μM (IMP-7), respectively [1].
|
-
- HY-N0406
-
|
|
P-glycoprotein
|
Inflammation/Immunology
|
|
2"-O-beta-L-galactopyranosylorientin is extracted from the flowers of Trollius ledebouri. 2"-O-beta-L-galactopyranosylorientin involves transporter mediated efflux in addition to passive diffusion and is the substrate of multidrug resistance protein 2 (MRP2). Anti-inflammatory effect [1] .
|
-
- HY-137816
-
|
|
β-glucuronidase
|
Others
|
|
6-Chloro-3-indolyl-β-D-glucuronide cyclohexylammonium salt is a chromogenic substrate for β-glucuronidase. 6-Chloro-3-indolyl-β-D-glucuronide cyclohexylammonium salt produces a salmon colored precipitate upon cleavage [1].
|
-
- HY-164136
-
|
|
17β-HSD
|
Metabolic Disease
|
|
17β-HSD5 inhibitor 1 (Compound 29) is a potent 17β-HSD5 inhibitor, with an IC50 of 2.9 nM in HEK-293 cells overexpressing human 17β-HSD5 [1].
|
-
- HY-N5094
-
|
|
Others
|
Others
|
|
6'-O-β-Apiofuranosylsweroside is a secoiridoid glycoside that can be isolated from the leaves of Lonicera angustifolia Wall [1].
|
-
- HY-P0265AS
-
|
Amyloid beta-Peptide-15N (1-40) (human) TFA; Amyloid β-Peptide-15N (1-40) (human) TFA
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid- 15N (1-40) (TFA) is the 15N-labledβ-Amyloid (1-40) (TFA). β-Amyloid (1-40) is a primary protein in plaques found in the brains of patients with Alzheimer's disease[1].
|
-
- HY-N11631
-
|
|
Others
|
Others
|
|
1-O-trans-Cinnamoyl-β-D-glucopyranose is a nature product. 1-O-trans-Cinnamoyl-β-D-glucopyranose can be isolated from fruits [1].
|
-
- HY-P2562
-
|
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (1-38), mouse, rat is composed of 38 aa (1-38 residues of the Aβ peptide) and is the primary component of the amyloid plaques of Alzheimer’s disease [1].
|
-
- HY-137553
-
|
SM934 free base
|
NOD-like Receptor (NLR)
|
Inflammation/Immunology
|
|
β-Aminoarteether (SM934 free base) is an Artemisinin derivative with orally active. β-Aminoarteether can be used for inflammation and autoimmune disease research, such as lupus diseases [1].
|
-
- HY-W288676
-
|
|
Biochemical Assay Reagents
|
Others
|
|
6-Fluoro-3-indolyl-β-D-galactopyranoside is a chromogenic enzyme substrate commonly used in microbiology to detect the expression of β-galactosidase in bacterial colonies.
|
-
- HY-W015546R
-
|
|
Bacterial
mGluR
PKC
|
Neurological Disease
Inflammation/Immunology
|
|
Clenbuterol (Standard) is the analytical standard of Clenbuterol. This product is intended for research and analytical applications. Clenbuterol (NAB-365) is a β2-adrenergic receptor agonist with an EC50 of 31.9 nM [1]. Clenbuterol is a very potent inhibitor of the lipopolysaccharide (LPS)-induced release of TNF-α and IL-1β. Clenbuterol can inhibit the inflammatory process. Clenbuterol is a bronchodilator .
|
-
- HY-P5810
-
|
CcoTx2; β-TRTX-cm1b
|
Sodium Channel
|
Neurological Disease
|
|
Ceratotoxin-2 (CcoTx2) is a voltage-gated sodium channel blocker with IC50s of 8 nM and 88 nM against Nav1.2/β1 and Nav1.3/β1, respectively [1].
|
-
- HY-133972
-
-
- HY-N10525
-
|
|
Others
|
Others
|
|
3α,4β-Galactotriose is a galactosyl residue [1].
|
-
- HY-P3781
-
|
|
Amyloid-β
|
Neurological Disease
|
|
(Met(O)35)-Amyloid β-Protein (1-42) is the oxidation form of Met35 in Aβ42. (Met(O)35)-Amyloid β-Protein (1-42) can yield an oligomer size distribution characteristic of Aβ40. (Met(O)35)-Amyloid β-Protein (1-42) can be used in the research of Alzheimer’s disease (AD) [1].
|
-
- HY-N5129
-
|
|
Others
|
Others
|
|
Genistein 7-O-β-D-glucopyranoside-4'-O-[α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside] is an isoflavone triglycoside that could be isolated from Sophora japonica [1].
|
-
![Genistein 7-O-β-D-glucopyranoside-4'-O-[α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside]](//file.medchemexpress.com/product_pic/hy-n5129.gif)
- HY-143414
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
Metallo-β-lactamase-IN-6 is a potent VIM-Type metallo-β-lactamase inhibitor with IC50s of 0.56 μM, 29.50 μM and 5.78 μM for VIM-2, VIM-1 and VIM-5. Metallo-β-lactamase-IN-6 displays potent synergistic antibacterial activity with Meropenem against engineered Escherichia coli strains and intractable clinically isolated Pseudomonas aeruginosa producing VIM-2 MBL [1].
|
-
- HY-N12077
-
|
|
Parasite
|
Infection
|
|
Eurycomanol 2-O-β-D-glucopyranoside (compound 4) is a natural product that can be obtained from Eurycoma longifolia. Eurycomanol 2-O-β-D-glucopyranoside has the potential for anti-malarial research [1].
|
-
- HY-N12856
-
|
|
Others
|
Others
|
|
Cyclo-olivil-9-O-β-glucopyranoside can be isolated from the root of Urtica triangularis HAND-MASS. Cyclo-olivil-9-O-β-glucopyranoside can be used in the drug development [1].
|
-
- HY-160788
-
-
- HY-N6986
-
|
Liquiritigenin-7-apiosylglucoside
|
Others
|
Cancer
|
|
Liquiritigenin-7-O-β-D-glucopyranosyl-(1→2)-β-D-apiofuranoside (Liquiritigenin-7-apiosylglucoside) is a flavonoid isolated from the roots of Glycyrrhiza, has weaker cytotoxicity against several tumor cells and normal cells [1].
|
-
- HY-N3523
-
|
|
Others
|
Cancer
|
|
3-O-Beta-D-Glucopyranosylplatycodigenin is an oleanane-type triterpenoid isolated from roots of Platycodon grandiflorum. 3-O-Beta-D-Glucopyranosylplatycodigenin exhibits anti-proliferative activities against HSC-T6 cell line with an IC50 of 13.36 μM [1].
|
-
- HY-161087
-
|
|
β-catenin
|
Cancer
|
|
β-catenin/BCL9 PPI-IN-1 (compound B4) is a potent inhibitor of β catenin/B-Cell lymphoma 9 protein?protein interaction (β catenin/BCL9 PPI) with the IC50 value of 2.25 μM [1].
|
-
- HY-139702
-
|
|
Integrin
|
Cancer
|
|
α5β1 integrin agonist-1, acting as α5β1 integrin agonist, is able to selectively deliver 5-FU into tumor cells, successfully leading to cancer cell death.
|
-
- HY-N8788
-
|
|
Others
|
Inflammation/Immunology
Cancer
|
|
Baicalein 7-O-β-D-ethylglucuronide is a natural flavone glycoside that can be extracted from Scutellaria baicalensis Georgi. Baicalein 7-O-β-D-ethylglucuronide has antioxidant activity. Baicalein 7-O-β-D-ethylglucuronide inhibits FeSO4-Cys-induced lipid peroxidation of liver homogenate. Baicalein 7-O-β-D-ethylglucuronide also shows strong cytoprotective effect on H2O2-induced oxidative damage of human umbilical vein endothelial cells [1] .
|
-
- HY-P1363S
-
|
Amyloid β-peptide-15N (1-42) (human) TFA
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid- 15N (1-42), human (TFA) is the 15N-labledβ-Amyloid (1-42) (TFA). β-Amyloid (1-42), human TFA (Amyloid β-Peptide (1-42) (human) TFA) is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease[1].
|
-
- HY-W009472
-
-
- HY-W722177
-
-
- HY-170743
-
-
- HY-W283245
-
-
- HY-W569842
-
-
- HY-W283166
-
-
- HY-W850994
-
|
Tridecyl beta-D-maltopyranoside
|
Biochemical Assay Reagents
|
Others
|
|
Tridecyl β-D-maltopyranoside is a synthetic sugar, modified by fluorination and methylation. Carbohydrates can be used for the synthesis of glycosylated proteins (biosynth: W-204093).
|
-
- HY-153060
-
-
- HY-W144276
-
-
- HY-122813S1
-
-
- HY-151201
-
|
|
Steroid Sulfatase
|
Cancer
|
|
Steroid sulfatase/17β-HSD1-IN-3 (compound 19) is a dual inhibitor of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1 (17β HSD1). Steroid sulfatase/17β-HSD1-IN-3 irreversibly inhibits hSTS activity with anIC50 value of 27 nM. Steroid sulfatase/17β-HSD1-IN-3 can be used in the study of endometriosis and other estrogen-dependent diseases [1].
|
-
- HY-151202
-
|
|
Steroid Sulfatase
|
Cancer
|
|
Steroid sulfatase/17β-HSD1-IN-4 (compound 37) is a dual inhibitor of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1 (17β HSD1). Steroid sulfatase/17β-HSD1-IN-4 irreversibly inhibits hSTS activity with anIC50 value of 63 nM. Steroid sulfatase/17β-HSD1-IN-4 can be used in the study of endometriosis and other estrogen-dependent diseases [1].
|
-
- HY-P1362F
-
|
Cy5-Amyloid β Peptide (42-1)(human) Tris
|
Amyloid-β
|
Neurological Disease
|
|
Cy5-β-Amyloid (42-1), human is a Cy5 fluorescently-labelled β-Amyloid (42-1, human) peptide (λex= 633 nm and λem= 670 nm) [1].
|
-
- HY-E70079
-
|
CBL
|
Biochemical Assay Reagents
|
Infection
|
|
Cystathionine β-lyase, Recombinant Microorganisms (CBL) is an enzyme that catalyzes the breakdown of cystathionine to homocysteine, the penultimate step in methionine biosynthesis. Cystathionine β-lyase is important for bacterial virulence [1].
|
-
- HY-N9121
-
|
|
Others
|
Others
|
|
8β-(4-Acetoxy-5-hydroxytigloyloxy)costunolide (compound 5) is a sesquiterpene lactone that can be isolated from Stevia alpina var. glutinosa [1].
|
-
- HY-114392
-
|
|
FXR
Autophagy
|
Metabolic Disease
|
|
Gly-β-MCA, a bile acid, is a potent, sable, intestine-selective and oral bioactive farnesoid X receptor (FXR) inhibitor that may be a candidate for the treatment of metabolic disorders [1].
|
-
- HY-N12609
-
|
|
Others
|
Inflammation/Immunology
|
|
3β-Isodihydrocadambine, a derivative of cadambine, is obtained from the bark and leaves of Neolamarckia cadamba and possesses notable antimalarial, antiproliferative, antioxidant, anticancer, and anti-inflammatory properties.
|
-
- HY-N8163
-
|
|
Others
|
Others
|
|
Kaempferol-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside is an antioxidant with an IC50 of 26.6 μM (DPPH assay) [1].
|
-
- HY-151199
-
|
|
Steroid Sulfatase
|
Endocrinology
Cancer
|
|
Steroid sulfatase/17β-HSD1-IN-1 is a potent steroid sulfatase and 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) inhibitor with an IC50 value of 28 nM for cellular human steroid sulfatase. Steroid sulfatase/17β-HSD1-IN-1 can be used to research estrogen-dependent diseases [1].
|
-
- HY-N7173
-
|
|
Parasite
|
Infection
|
|
7-Methoxy-β-carboline-1-propionic acid (compound 46) is a cytotoxic and antimalarial compound. 7-Methoxy-β-carboline-1-propionic acid can be extracted from the roots of Eurycoma longifolia [1].
|
-
- HY-150672S
-
|
Vanillin-d3 2’,3’,4’,6’-O-tetraacetyl-β-D-glucoside
|
Isotope-Labeled Compounds
|
Others
|
|
Tetra-O-acetyl-β-D-glucopyranosylvanilin-d3 is the deuterium labeled Tetra-O-acetyl-β-D-glucopyranosylvanilin[1].
|
-
- HY-W127488
-
|
Coprostane
|
Biochemical Assay Reagents
|
Others
|
|
5β-Cholestane is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-153671
-
|
|
Fungal
|
Infection
|
|
4'-Methyl-β-naphthoflavone is a metabolite of Naphthoflavones (benzoflavones) in fungal. Naphthoflavones are activators or inhibitors of CYP-450 [1].
|
-
- HY-20696
-
|
Tryptoline
|
5-HT Receptor
|
Metabolic Disease
|
|
Tetrahydro-β-carboline (Tryptoline) is a metabolite of tryptamine, also is a competitive serotonin reuptake inhibitor with an Ki value of 6.1 µM [1].
|
-
- HY-W039923
-
|
|
Insulin Receptor
|
Endocrinology
|
|
β-D-Galactose pentaacetate is a negative regulator of insulin with plasma membrane penetrating ability and can be hydrolyzed by intracellular esterases. β-D-Galactose pentaacetate inhibits leucine-induced insulin release in Wistar rat islets, potentially preventing excessive insulin release in pathological conditions [1].
|
-
- HY-P2289A
-
|
pBD-1 TFA
|
Bacterial
|
Infection
|
|
β-defesin 1 (pig) (pBD-1) TFA is an endogenous and constitutively expressed antimicrobial peptide (AMP) from porcine tissues, particularly expresses in pig mucosal epithelial sites. β-defesin 1 (pig) TFA has antimicrobial activities and contributes to mucosal and systemic host defenses in pigs [1].
|
-
- HY-W154341
-
|
|
Biochemical Assay Reagents
|
Others
|
|
3-Indolyl-β-D-glucuronide cyclohexanamine is the glucose component of X-Gluc staining buffer. 3-Indolyl-β-D-glucuronide cyclohexanamine can be used to detect gene expression. The active ingredient of the stain, β-Glucuronidase (GUS), reacts with the enzyme, causing the target gene to appear blue-purple in tissues or cells, so that the expression level and tissue distribution of the gene can be visually observed [1].
|
-
- HY-137339
-
|
|
Drug Metabolite
|
Others
|
|
Amitriptyline N-β-D-glucuronide is an ammonium glucuronide and an urinary excretion metabolite of amitriptyline [1].
|
-
- HY-P2803
-
|
|
β-glucuronidase
|
Metabolic Disease
|
|
Beta-glucuronidase is an important lysosomal enzyme involved in the degradation of glucuronate-containing glycosaminoglycan [1].
|
-
- HY-P2803A
-
|
|
β-glucuronidase
|
Metabolic Disease
|
|
Beta-glucuronidase is an important lysosomal enzyme involved in the degradation of glucuronate-containing glycosaminoglycan [1].
|
-
- HY-139720
-
-
- HY-P1894
-
|
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid Protein Precursor 770 (135-155) is a peptide of amyloid precursor protein isoform (APP 770). APP 770 produces Aβ40/42 [1].
|
-
- HY-P4640
-
-
- HY-139733
-
|
|
Others
|
Others
|
|
β-N-Acetyl-D-hexosaminidase-IN-1 is a novel β-N-acetyl-d-hexosaminidase inhibitor with a Ki value of 3.72 μM.
|
-
- HY-P4861
-
|
|
Amyloid-β
|
Others
|
|
Biotinyl-Ahx-Amyloid β-Protein (1-42) is abiotinylated β-Amyloid (1-42), human (TFA) (HY-P1363).
|
-
- HY-W727768
-
-
- HY-N8126
-
|
Glucoemodin
|
Others
|
Metabolic Disease
Inflammation/Immunology
|
|
Emodin-6-O-β-D-glucoside (Glucoemodin) is an active compound from Reynoutria japonica. Emodin-6-O-β-D-glucoside shows potent anti-inflammatory and barrier protective effects. Emodin-6-O-β-D-glucoside can be used for the research of diabetic complications and atherosclerosis [1].
|
-
- HY-137912
-
|
|
Drug Metabolite
|
Endocrinology
Cancer
|
|
trans-Resveratrol-3-O-β-D-Glucuronide is an active metabolite of trans-resveratrol. trans-Resveratrol-3-O-β-D-Glucuronide reduces the proliferation of several intestinal cancer cell line. trans-Resveratrol-3-O-β-D-Glucuronide increases pyruvate production in livers [1] .
|
-
- HY-W015546
-
|
BMAA hydrochloride
|
Bacterial
mGluR
PKC
|
Neurological Disease
Inflammation/Immunology
|
|
β-N-methylamino-L-alanine hydrochloride (BMAA hydrochloride) is a neurotoxin produced by cyanobacteria. β-N-methylamino-L-alanine hydrochloride activates mGluR3 and inhibits PKC. β-N-methylamino-L-alanine hydrochloride can be used in the research of neurodegenerative diseases and immune diseases [1] .
|
-
- HY-N7661
-
|
|
PPAR
|
Metabolic Disease
|
|
4β-Hydroxywithanolide E, isolated from Physalis peruviana L., inhibits adipocyte differentiation of 3T3-L1 cells through modulation of mitotic clonal expansion. 4β-Hydroxywithanolide E is an adipogenesis inhibitor and inhibits PPARγ, C/EBPα, and the adipocyte-specific molecule aP2 mRNA expression [1].
|
-
- HY-N10634
-
|
C16 Glucosyl(β) Ceramide (d18:1/16:0)
|
Others
|
Inflammation/Immunology
|
|
D-Glucosyl-β-1,1′-N-palmitoylsphingosine (C16 Glucosyl(β) Ceramide (d18:1/16:0)) is an endogenous Mincle ligand possessing immunostimulatory activity [1].
|
-
- HY-137522
-
|
3'-Azido-3'-deoxythymidine β-D-glucuronide sodium
|
Drug Metabolite
|
Others
|
|
Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the major metabolite of Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection [1] . Zidovudine O-β-D-glucuronide (sodium) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-160493
-
|
|
Wnt
β-catenin
|
Cancer
|
|
PTK7/β-catenin-IN-6 (Compound 03653) is an inhibitor for PTK7/β-catenin interaction, which inhibits the Wnt signaling pathway, and exhibits an anticancer activity against colorectal cancer (CRC) [1].
|
-
- HY-145736
-
|
|
Drug-Linker Conjugates for ADC
Apoptosis
|
Cancer
|
|
β-Glucuronide-dPBD-PEG5-NH2 is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD. β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2, as a proagent of cIRCR201-dPBD, reduces side effects. β-Glucuronide-dPBD-PEG5-NH2 can induce apoptosis and arrest cell cycle. β-Glucuronide-dPBD-PEG5-NH2 has antitumor activity [1].
|
-
- HY-137234
-
|
2,6-Di-O-methyl-β-cyclodextrin
|
Biochemical Assay Reagents
|
Others
|
|
DM-β-CD (2,6-Di-O-methyl-β-cyclodextrin) is a cyclic molecule consisting of seven glucose units modified with two methyl groups at the 2- and 6-positions. It is usually used as a solubilizer and carrier for poorly soluble drugs in pharmaceutical preparations. Furthermore, it has applications in analytical chemistry, food science, and environmental remediation due to its ability to form clathrates with various guest molecules, such as aromatic compounds, pesticides, and heavy metals.
|
-
- HY-107231
-
-
- HY-W416249
-
-
- HY-W699225
-
-
- HY-W739438
-
-
- HY-W567866
-
-
- HY-153124
-
-
- HY-N13718
-
|
|
Others
|
Others
|
|
Irisolidone 7-O-β-D-glucopyranoside is an active compound.
|
-
- HY-W345103
-
-
- HY-W010824
-
-
- HY-W742736
-
-
- HY-N2287
-
-
- HY-E70060
-
|
EB4GALT1 (LgtE)
|
Others
|
Others
|
|
beta-1,4-Galactosyltransferase (LgtE) (EB4GALT1 (LgtE)) catalyzes the reaction involving UDP-galactose and N-acetylglucosamine for the production of galactose beta-1,4-N-acetylglucosamine [1].
|
-
- HY-173482
-
|
|
Wnt
β-catenin
|
Cancer
|
|
TFAP4/Wnt/β-catenin-IN-1 (Compound A61) is an orally active TFAP4/Wnt/β-catenin inhibitor. TFAP4/Wnt/β-catenin-IN-1 has significant anticancer activity against a variety of cancer cells (such as gastric cancer, lung cancer, breast cancer, etc.), and has the strongest anticancer activity against MGC-803 gastric cancer cells (IC50: 3.92 μM). TFAP4/Wnt/β-catenin-IN-1 induces apoptosis and cell cycle arrest (S phase) in cancer cells by inhibiting the TFAP4/Wnt/β-catenin signaling pathway. TFAP4/Wnt/β-catenin-IN-1 can be used in the study of gastric cancer [1].
|
-
- HY-132239
-
|
5-Bromo-6-chloro-3-indolyl-beta-D-galactoside
|
Biochemical Assay Reagents
|
Others
|
|
5-Bromo-6-chloro-3-indolyl β-D-Galactopyranoside (contains ca. 10% Ethyl Acetate) (5-Bromo-6-chloro-3-indolyl-beta-D-galactoside) is a chromogenic substrate of β-galactosidase (β-gal) [1].
|
-
- HY-B0141S2
-
|
β-Estradiol-d5; 17β-Estradiol-d5; 17β-Oestradiol-d5
|
Estrogen Receptor/ERR
Endogenous Metabolite
|
Endocrinology
Cancer
|
|
Estradiol-d5 is deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].
|
-
- HY-B0141S3
-
-
- HY-B0141S1
-
|
β-Estradiol-d4; 17β-Estradiol-d4; 17β-Oestradiol-d4
|
Estrogen Receptor/ERR
Endogenous Metabolite
|
Endocrinology
Cancer
|
|
Estradiol-d4 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].
|
-
- HY-N7918
-
|
|
Others
|
Others
|
|
17β-Tenacigenin B is a pregnane genin that can be isolated from XAPI, a traditional anticancer Chinese medicinal formula [1].
|
-
- HY-P3179
-
|
|
Biochemical Assay Reagents
|
Others
|
|
1,3-β-Glucanase is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-146972S
-
-
- HY-136306
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
Metallo-beta-lactamase ligand 1 is a class B β-lactamase inhibitor with antibacterial activity extracted from patent WO2019221122A1, compound A [1].
|
-
- HY-154772S
-
-
- HY-P2550A
-
|
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid (1-40), FAM-labeled TFA is a FAM fluorescently-labelled β-Amyloid (1-40) peptide (λex= 492 nm and λem= 518 nm).
|
-
- HY-133961
-
|
Cholesteryl glucoside
|
HSP
|
Metabolic Disease
|
|
Cholesterol β-D-glucoside (Cholesteryl glucoside) is a heat shock transcription factor 1 (HSF1) activator. Cholesterol β-D-glucoside induces HSP70 in fibroblast cells [1].
|
-
- HY-113018
-
-
- HY-N10639
-
|
|
Others
|
Others
|
|
(1α,2α,6β,8α,9α)-1,2,6,8,12-Pentakis(acetyloxy)-9-(benzoyloxy)dihydro-β-agarofuran is a sesquiterpene polyol ester. (1α,2α,6β,8α,9α)-1,2,6,8,12-Pentakis(acetyloxy)-9-(benzoyloxy)dihydro-β-agarofuran can be used for the research of various biochemical [1].
|
-
- HY-157129
-
|
|
AMPK
|
Cardiovascular Disease
|
|
AMPK-α1β1γ1 activator 1 (M1) is an acyl glucuronide metabolite of Indole-3-carboxylic Acid-based AMPK activator. AMPK-α1β1γ1 activator 1 can selectively activated human β1 isoforms with an EC50 value of 38.1nM. AMPK-α1β1γ1 activator 1 can direct binding with human AMPK α1β1γ1 isoform. AMPK-α1β1γ1 activator 1 can be used for the research of diabetic nephropathy [1].
|
-
- HY-N3864
-
|
|
Others
|
Others
|
|
Erythro-Guaiacylglycerol beta-coniferyl ether (compound 22) can be isolated from the stems and leaves of mung beans. Erythro-Guaiacylglycerol beta-coniferyl ether inhibits α-Glycosidase activity with EC50 value of 18.71 μM [1].
|
-
- HY-167696
-
|
|
11β-HSD
|
Neurological Disease
|
|
11β-HSD1-IN-16 is an inhibitor of the 11β-hydroxysteroid dehydrogenase HSD11B1, demonstrating an IC of 0.34 μM, making it a valuable tool for research on neuropathic pain, inflammatory pain, and occipital neuralgia.
|
-
- HY-N8218
-
-
- HY-E70132
-
|
Endo D
|
Glycosidase
|
Metabolic Disease
|
|
Endo-β-N-acetylglucosaminidase D (Endo D), isolated from Streptococcus pneumoniae. Endo-β-N-acetylglucosaminidase D hydrolyzes Fc N-glycan of intact IgG antibodies after sequential removal of the sialic acid, galactose, and internal GlcNAc residues in the N-glycan. Endo-β-N-acetylglucosaminidase D possesses transglycosylation activity with sugar oxazoline as the donor substrate [1].
|
-
- HY-152476
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
3’-β-C-Ethynyluridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents [1]. 3’-β-C-Ethynyluridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-N13639
-
|
|
Others
|
Others
|
|
β-D-Glucopyranosyl taraxinic ester is a natural product that can be isolated from Taraxacum portentosum [1].
|
-
- HY-W400496
-
|
|
HDAC
|
Cancer
|
|
Valproic acid β-D-glucuronide is the major urinary metabolite of Valproic acid (HY-10585) [1].
|
-
- HY-N9322
-
|
|
Others
|
Cancer
|
|
Bergaptol O-β-D-glucopyranoside possesses anti-gastric ulcer and anti-cancer effect [1].
|
-
- HY-W585982
-
-
- HY-N12382
-
|
|
Others
|
Others
|
|
2-Phenethyl β-primeveroside is a phenplic that can be isolated from Callianthemum taipaicum [1].
|
-
- HY-N9702
-
|
|
Others
|
Others
|
|
n-Butyl-β-D-fructopyranoside is a fructopyranoside can be isolated from Myrica rubra (Myricaceae) [1].
|
-
- HY-137611A
-
|
|
DNA/RNA Synthesis
|
Cancer
|
|
α,β-MTDP trisodium, a thymidylate analog, is a thymidine kinase inhibitor with a Ki of 23 µM [1].
|
-
- HY-N11516
-
|
|
Others
|
Others
|
|
Erythro-guaiacylglycerol-β-ferulic acid ether is a natural product that can be isolated from Gueldenstaedtia verna [1].
|
-
- HY-N0230R
-
|
2-Carboxyethylamine (Standard); 3-Aminopropanoic acid (Standard)
|
Endogenous Metabolite
|
Metabolic Disease
|
|
β-Alanine (Standard) is the analytical standard of β-Alanine. This product is intended for research and analytical applications. β-Alanine is a non-essential amino acid that is shown to be metabolized into carnosine, which functions as an intracellular buffer.
|
-
- HY-B0203A
-
|
R 065824 hydrochloride
|
Adrenergic Receptor
|
Cardiovascular Disease
Endocrinology
Cancer
|
|
Nebivolol (R 065824) hydrochloride is an orally active beta receptor blocker and has the high beta(1)-receptor affinity.Nebivolol hydrochloride has direct vasodilator properties and adrenergic blocking characteristics. Nebivolol hydrochloride can be used for the research of kinds of diseases such as hypertension, coronary artery disease, congestive heart failure and ischemic heart disease [1] .
|
-
- HY-B0203
-
|
R 065824
|
Adrenergic Receptor
|
Cardiovascular Disease
Endocrinology
Cancer
|
|
Nebivolol (R 065824) is an orally active beta receptor blocker and has the high beta(1)-receptor affinity. Nebivolol has direct vasodilator properties and adrenergic blocking characteristics. Nebivolol can be used for the research of kinds of diseases such as hypertension, coronary artery disease, congestive heart failure and ischemic heart disease [1] .
|
-
- HY-116591
-
|
|
Endogenous Metabolite
|
Endocrinology
|
|
8-ISo-15-keto prostaglandin F2β is a potential metabolite of 8-Iso PGF2β via the 15-hydroxy-PG dehydrogenase pathway. 8-iso PGF2β constricts pulmonary veins in dogs and pigs [1] .
|
-
- HY-P4882A
-
|
|
Amyloid-β
|
Neurological Disease
|
|
(Pyr3)-Amyloid β-Protein (3-42) TFA is the predominant amyloid β-peptide structure deposited in human brain of Alzheimer's disease and Down's syndrome patients. (Pyr3)-Amyloid β-Protein (3-42) TFA is suggested to accumulate in the brain and to trigger the formation of insoluble amyloid β-peptide deposits [1].
|
-
- HY-N12032
-
|
|
Others
|
Others
|
|
Acacetin 7-O-β-D-xylopyranosyl-(1→2)[α-L-rhamnopyranosyl-(1→6)]-β-D-glucopyranoside (Compound 10), a flavone glycoside, can be isolated from extracts of the leaves of Robinia pseudoacacia [1].
|
-
![Acacetin 7-O-β-D-xylopyranosyl-(1→2)[α-L-rhamnopyranosyl-(1→6)]-β-D-glucopyranoside](//file.medchemexpress.com/product_pic/hy-n12032.gif)
- HY-N12816
-
|
|
Others
|
Others
|
|
Glaucogenin C 3-O-α-L-cymaropyranosyl-(1→4)–β-D-digitoxopyranosyl-(1→4)-β-D-Canaropyranoside is a steroidal glycoside and can be isolated from Cynanchum stauntonii [1].
|
-
- HY-W353804
-
|
|
Nucleoside Antimetabolite/Analog
|
Infection
|
|
2'-Deoxy-β-L-uridine is a nucledside analogue and a specific substrate for the viral enzyme, shows no stereospecificity against herpes simplex 1 (HSV1) thymidine kinase (TK). 2′-Deoxy-β-L-uridine exerts antiviral activity via the interation of 5'-triphosphates with the viral DNA polymerase [1] .
|
-
- HY-P3343A
-
|
|
Estrogen Receptor/ERR
|
Cancer
|
|
hFSH-β-(33-53) TFA, a thiol-containing peptide which corresponds to a second FSH receptor-binding domain, is a FSHR (follicle-stimulating hormone receptor) antagonist. hFSH-β-(33-53) TFA inhibits binding of FSH to receptor and is a partial agonist of estradiol synthesis in Sertoli cells [1] .
|
-
- HY-W698686
-
|
|
Biochemical Assay Reagents
|
|
|
β-Galactosyl-C18-ceramide is a bioactive molecule that promotes the regulation of nerve cells, regulates protein kinase C activity, and affects hormone receptors. β-Galactosyl-C18-ceramide is widely used in neuroscience research to explore its effects on nerve cell growth and function. The regulatory function of β-Galactosyl-C18-ceramide makes it a potential application prospect in compound development and disease inhibition.
|
-
- HY-P4391
-
-
- HY-133972S
-
-
- HY-164138
-
|
|
17β-HSD
|
Cancer
|
|
17β-HSD5 inhibitor 3 (Compound 31) is an orally active inhibitor for 17β-HSD5 with an IC50 of 69 nM [1].
|
-
- HY-142581S
-
-
- HY-N5091
-
|
|
Others
|
Inflammation/Immunology
Cancer
|
|
Physcion 8-O-β-D-glucopyranosideis an anthraquinone compound isolated from Rumex japonicus Houtt. Physcion 8-O-β-D-glucopyranoside exerts anti-inflammatory and anti-cancer properties, can be for common malignancy cancer research [1].
|
-
- HY-P4585
-
|
|
Amyloid-β
|
Neurological Disease
|
|
(Gln22)-Amyloid β-Protein (1-42) is a Dutch mutation (E22Q) form of β-Amyloid (1-42) (HY-P1363). (Gln22)-Amyloid β-Protein (1-42) exhibits enhanced fibrillogenic and pathogenic properties [1].
|
-
- HY-W585982S
-
-
- HY-N6911
-
|
(18β,20α)-Glycyrrhizic acid
|
Others
|
Metabolic Disease
|
|
Licorice-saponin H2 ((18β,20α)-Glycyrrhizic acid) is a saponin from Glycyrrhiza uralensis Fischer [1].
|
-
- HY-172393
-
|
|
β-catenin
Apoptosis
Caspase
MDM-2/p53
Bcl-2 Family
Cytochrome P450
|
Cancer
|
|
TCF4/β-catenin-IN-1 (Compound 8b) is an inhibitor of TCF4/β-catenin, and induces apoptosis. TCF4/β-catenin-IN-1 up-regulates p53, caspase-3, caspase-8, caspase-9 levels and Bax protein expression as well as down-regulates Bcl-2 protein expression. TCF4/β-catenin-IN-1 can inhibit CYP3A4, CYP1A2, CYP2C19, and shows promising cytotoxic activity in cancer cells [1].
|
-
- HY-100084
-
|
|
ROR
|
Inflammation/Immunology
|
|
Methyl-3β-hydroxycholenate is a ROR gamma modulator extracted from patent US20110263046 A1, in figure 2.
|
-
- HY-W739883
-
-
- HY-N3079
-
|
Phloroglucinol β-D-glucoside
|
Others
|
Others
|
|
Phlorin (Phloroglucinol β-D-glucoside) is a phloroglucinol (PG) glucoside [1].
|
-
- HY-137336
-
-
- HY-W013815
-
-
- HY-W040302
-
-
- HY-N13343
-
|
|
Others
|
Others
|
|
1-Methoxycarbonyl-beta-carboline-N-oxide is a natural product [1].
|
-
- HY-W787458
-
-
- HY-W399633
-
-
- HY-W142867
-
-
- HY-P990332
-
|
CNTO 2125
|
Amyloid-β
|
Inflammation/Immunology
|
|
Anti-Amyloid Beta Antibody (CNTO 2125) is a humanized antibody expressed in CHO cells, targeting Amyloid Beta/Aβ. Anti-Amyloid Beta Antibody (CNTO 2125) features a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for Anti-Amyloid Beta Antibody (CNTO 2125) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-W129395
-
|
6-O-Tosyl-β-cyclodextrin
|
Biochemical Assay Reagents
|
Others
|
|
Mono-(6-p-toluenesulfonyl)-β-cyclodextrin is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W354066
-
|
|
Biochemical Assay Reagents
|
|
|
Biochanin A-7-O-β-D-glucuronide is a glucuronidated derivative of phytoestrogen, which has the ability to study the metabolic activity of phytoestrogen in the ecosystem. Biochanin A-7-O-β-D-glucuronide plays an important role in ecological research. Biochanin A-7-O-β-D-glucuronide is used to explore the interaction between plants and the environment.
|
-
- HY-163536
-
|
|
TGF-beta/Smad
|
Inflammation/Immunology
|
|
TGF-β1/Smad3-IN-1 (Compound 5aa) is an inhibitor of the TGF-β1/Smad3 signaling pathway(IC50=1.07 μM). TGF-β1/Smad3-IN-1 possesses antifibrotic activity and oral potency [1].
|
-
- HY-152810
-
|
|
Nucleoside Antimetabolite/Analog
|
Others
|
|
2-Ami no-9-(2-β-C-methyl-β-D-ribofuranosyl)-9H-purine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc [1].
|
-
- HY-E70050
-
|
GM1-synthase
|
Endogenous Metabolite
|
Others
|
|
beta-1,3-Galactosyltransferase (CgtB) (GM1-synthase) is an enzyme that required for sialylated lipooligosaccharide (LOS SIAL) production, is often used in biochemical studies. beta-1,3-Galactosyltransferase (CgtB) catalyzes the addition of a galactose molecule, which is required for GM1-like LOS SIAL structure production [1].
|
-
- HY-P1548A
-
|
Human β-CGRP TFA; CGRP-II (Human) (TFA)
|
CGRP Receptor
|
Cardiovascular Disease
Inflammation/Immunology
|
|
β-CGRP, human TFA (Human β-CGRP TFA) is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC50s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells [1].
|
-
- HY-112023
-
|
9β,10α-Cholesta-5,7-dien-3β-ol; Cholecalciferol EP Impurity C
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Lumisterol 3 (>90%) (9β,10α-Cholesta-5,7-dien-3β-ol) is a normal human secosterooid metabolite from the class of vitamin D3 photoisomer derivatives. Lumisterol 3 (>90%) is used in the preparation of vitamin D [1].
|
-
- HY-N12070
-
|
|
Others
|
Cardiovascular Disease
|
|
11-O-β-D-glucopyranosyl thamnosmonin, a coumarin glucosides, can be isolated from the roots of Angelica apaensis. 11-O-β-D-glucopyranosyl thamnosmonin has weak inhibitory activity on the aggregation of rabbit platelets induced by PAF, AA, and ADP [1].
|
-
- HY-W742564
-
|
|
Cholinesterase (ChE)
|
Neurological Disease
|
|
Acacetin-7-O-β-D-galactopyranoside is a flavonoid that can be isolated from flower heads of Chrysanthemum morifolium. Acacetin-7-O-β-D-galactopyranoside inhibits AChE activity and can be used for research of Alzheimer’s disease [1].
|
-
- HY-W039865
-
|
|
Biochemical Assay Reagents
|
Cancer
|
|
1-Thio-beta-D-glucose tetraacetate exhibits cytotoxicity in cells HeLa and human ocular lens epithelium CECH with IC50s of >250 and >200 μM. 1-Thio-beta-D-glucose tetraacetate reveals moderate anticancer property [1].
|
-
- HY-N12081
-
-
- HY-163471
-
|
|
PDGFR
VEGFR
|
Cancer
|
|
PDGFRα/β/VEGFR-2-IN-1 (6f), a multiple PDGFRα/ and VEGFR-2 tyrosine kinase inhibitor, particularly targets PDGFRα, PDGFRβ, and VEGFR-2 kinases with Nano molar concentrations [1].
|
-
- HY-137333
-
|
|
Fluorescent Dye
|
Others
|
|
4-Methylumbelliferyl β-D-cellobioside is a substrate of Cellulase (HY-B2220). 4-Methylumbelliferyl β-D-cellobioside can be hydrolyzed and produces fluorescent 4-methylumbelliferone, which can be used to study the kinetics of cellulases [1].
|
-
- HY-N3282
-
|
|
Others
|
Others
|
|
Methyl β-D-fructoside is a Miscellaneous product that can be isolated from the herbs of Pteris semipinnata [1].
|
-
- HY-148586
-
|
|
Drug Derivative
|
Others
|
|
β-Estradiol 17-hemisuccinate is a synthetic derivative of estradiol (HY-B0141) [1].
|
-
- HY-N8793
-
|
|
Others
|
Others
|
|
Hesperetin 5-β-D-glucopyranoside is a flavonoid component, that can be isolated from Prunus davidiana [1].
|
-
- HY-N12029
-
|
|
Others
|
Others
|
|
Acacetin 7-O-β-sophoroside is a flavonoid glycoside isolated from the rhizomes and roots of valerian [1].
|
-
- HY-N10371
-
|
|
Others
|
Others
|
|
Physcion-8-O-β-gentiobioside is an anthraquinone glycoside isolated from rhubarb roots [1].
|
-
- HY-N1137
-
|
(+)-Totaradiol; 3β-Hydroxytotarol
|
Others
|
Others
|
|
Totaradiol ((+)-Totaradiol; 3β-Hydroxytotarol) is a diterpene can be isolated from Thuja plicata (Cupressaceae) [1].
|
-
- HY-146630S
-
-
- HY-N9137
-
|
|
Others
|
Others
|
|
2α-Hydroxy-8β-(2-methylbutyryloxy)costunolide is a Sesquiterpenoids product that can be isolated from the aerial parts of Artemisia myriantha [1].
|
-
- HY-142798S
-
-
- HY-N9199
-
|
|
Others
|
Others
|
|
6β,19-Dihydroxyurs-12-en-3-oxo-28-oic acid (Compound 14) is an osteoclast inhibitor with anti-osteoclastogenic activity. 6β,19-Dihydroxyurs-12-en-3-oxo-28-oic acid can be obtained from Eriobotrya japonica leaves. 6β,19-Dihydroxyurs-12-en-3-oxo-28-oic acid can be used in osteoporosis research [1].
|
-
- HY-154743S
-
-
- HY-15679
-
|
|
PI4K
|
Cancer
|
|
PI4KIII beta inhibitor 3 is a novel and high effective PI4KIIIβ inhibitor with IC50 of 5.7 nM.
|
-
- HY-123357
-
|
|
Apoptosis
|
Neurological Disease
|
|
IMM-H004, a coumarin derivative, possesses neuroprotective and potent free radical scavenging abilities. IMM-H004 significantly inhibits amyloid-β (Aβ)-induced cytotoxicity and apoptosis, offering potential value for research into neurodegenerative diseases such as Alzheimer's disease. Additionally, IMM-H004 is also capable of effectively blocking the calcium mobilization and chemotaxis induced by CKLF1-C27 (HY-P3418), thereby alleviating asthmatic pathological changes in the lung tissue of CKLF1 transgenic mice [1].
|
-
- HY-162884
-
|
|
β-glucuronidase
|
Infection
|
|
EcGUS-IN-1 (Compound E-9) is a non-competitive β-glucuronidase inhibitor, with an IC50 of 2.68 μM and a Ki value of 1.64 μM. EcGUS-IN-1 can improve gastrointestinal adverse events (GIAE) caused by Escherichia coli infection by inhibiting E. coli β-glucuronidase activity [1].
|
-
- HY-107567B
-
|
β-Alanylhistamine dihydrochloride
|
Histamine Receptor
|
Neurological Disease
|
|
Carcinine (β-Alanylhistamine) dihydrochloride is a selective histamine H3 antagonist with antioxidant activity and neuroprotective effects on the retina of oxidatively stressed mice [1] .
|
-
- HY-138026
-
-
- HY-138247
-
|
EX-A4764; UUN51204
|
Beta-lactamase
Bacterial
Antibiotic
|
Infection
|
|
β-Lactamase-IN-2 is a beta-lactamase inhibitor, extracted from patent WO 2019075084 A1, compound 1. β-Lactamase-IN-2 has anti-microbial and anti-bacterial effects [1].
|
-
- HY-N0012
-
|
Glycitein 7-O-β-glucoside
|
Bacterial
|
Infection
Cancer
|
|
Glycitin (Glycitein 7-O-β-glucoside) is a natural isoflavone with antibacterial, antiviral, anticancer, anti-inflammation, anti-aging and estrogenic effects. Glycitin may regulate osteoblasts through TGF-β or AKT signaling pathways in bone marrow stem cells (BMSCs) [1] .
|
-
- HY-116285
-
|
|
Biochemical Assay Reagents
|
Others
|
|
n-Octyl-β-d-glucopyranoside is a non-ionic detergent, it can be widely used in the research of biotechnical, biochemical applications, solubilization and crystallization of membrane proteins. n-Octyl-β-d-glucopyranoside can completely inhibit cavitation-induced cell lysis in vitro [1] .
|
-
- HY-N9166
-
|
|
Others
|
Others
|
|
erythro-Guaiacylglycerol-β-O-4'-dehydrodisinapyl ether (Compound 122) inhibits lettuce germination. erythro-Guaiacylglycerol-β-O-4'-dehydrodisinapyl ether can be isolated from Brassica fruticulosa [1].
|
-
- HY-N10794
-
|
|
Others
|
Cancer
|
|
18β-Hydroxy-3-epi-α-yohimbine is a yohimbine derivative. 18β-Hydroxy-3-epi-α-yohimbine is a nature product that can be found in Rauvolfia vomitoria [1].
|
-
- HY-B0141
-
|
β-Estradiol; E2; 17β-Estradiol; 17β-Oestradiol
|
Estrogen Receptor/ERR
Endogenous Metabolite
Bacterial
|
Endocrinology
Cancer
|
|
Estradiol (β-Estradiol) is a steroid hormone and the major female sex hormone. Estradiol can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering [1] .
|
-
- HY-N12820
-
|
|
Others
|
Cancer
|
|
3-O-6-Deoxy-3-O-methyl-β-D-allopyranosyl-(1→4)-β-D-oleandropyranosyl-tenacigenin C can be isolated from Alocasia cucullata (Lour.) G. Don. 3-O-6-Deoxy-3-O-methyl-β-D-allopyranosyl-(1→4)-β-D-oleandropyranosyl-tenacigenin C has moderate tumor cells inhibitory activity against MGC-803 and HT-29 cells with IC50 values of 45.6 and 28.4 μg/mL, respectively [1].
|
-
- HY-W698686S
-
|
|
Isotope-Labeled Compounds
Others
|
Others
|
|
β-Galactosyl-C18-ceramide-d35 is deuterium labeled β-Galactosyl-C18-ceramide. β-Galactosyl-C18-ceramide is a bioactive molecule that promotes the regulation of nerve cells, regulates protein kinase C activity, and affects hormone receptors. β-Galactosyl-C18-ceramide is widely used in neuroscience research to explore its effects on nerve cell growth and function. The regulatory function of β-Galactosyl-C18-ceramide makes it a potential application prospect in compound development and disease inhibition [1].
|
-
- HY-N8667
-
|
|
Others
|
Others
|
|
7-Epi-5-eudesmene-1beta,11-diol is a Sesquiterpenoids product that can be isolated from the herbs of Physalis alkekengi [1].
|
-
- HY-N1714
-
|
|
Others
|
Others
|
|
29-Norcycloartan-23-ene-3beta,25-diol is a Triterpenoids product that can be isolated from the herbs of Aganosma marginata [1].
|
-
- HY-W416265
-
-
- HY-Y1824
-
-
- HY-W587724S
-
-
- HY-150132
-
-
- HY-W341133
-
-
- HY-W039893
-
-
- HY-W154351
-
-
- HY-N7957
-
|
|
Others
|
Others
|
|
Pratensein-7-O-β-D-glucopyranoside is a new isoflavone [1].
|
-
- HY-152474
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
2’-β-C-Ethynylcytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc [1]. 2’-β-C-Ethynylcytidine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-152475
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
2’-β-C-Ethynyladenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc [1]. 2’-β-C-Ethynyladenosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-N0087
-
|
beta-Guttiferrin
|
Bcl-2 Family
Autophagy
|
Cancer
|
|
Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.
|
-
- HY-121965
-
|
|
Biochemical Assay Reagents
Endogenous Metabolite
|
Others
|
|
β-D-Glucose, also known as glucose, is a monosaccharide, the most important carbohydrate in biological systems, the main energy source of cells, and plays a key role in various metabolic processes. β-D-Glucose has unique chemical properties that make it an abundant component in plant and animal tissues and is readily metabolized by organisms to produce cellular energy. It is commonly used to improve hypoglycemia and dehydration, and as a sweetener and preservative in food and beverage production.
|
-
- HY-137967
-
|
Genistein 7-O-glucuronide
|
VEGFR
|
Endocrinology
|
|
Genistein 7-β-D-Glucuronide is a natural product. Genistein 7-β-D-Glucuronide inhibits tubulogenesis and endothelial migration[1].
|
-
- HY-W039859
-
-
- HY-N12030
-
|
|
Others
|
Others
|
|
Acacetin 7-O-β-D-glucuronopyranosyl-(1→2)[α-L-rhamnopyranosyl-(1→6)]-β-D-glucopyranoside (compound 8) is a flavonoid glycoside that can be obtained from black locust (Leguminosae ) isolated from leaf extract [1].
|
-
![Acacetin 7-O-β-D-glucuronopyranosyl-(1→2)[α-L-rhamnopyranosyl-(1→6)]-β-D-glucopyranoside](//file.medchemexpress.com/product_pic/hy-n12030.gif)
- HY-N11990
-
|
|
Others
|
Others
|
|
Nortrachelogenin 4'-O-β-gentiobioside (compound 20) is a lignan isolated from the aerial parts of Trachelospermius [1].
|
-
- HY-N9372
-
-
- HY-141490
-
|
|
Drug Derivative
|
Others
|
|
Beta-D-Glucopyranosyl nitromethane, as a salt of a strongly basic anion exchanger in the OH cycle, is a glycosyl derivative of nitromethane [1].
|
-
- HY-P4724
-
-
- HY-N11542
-
|
|
Others
|
Others
|
|
Trachelogenin 4′-O-β-gentiobioside, a lignan, can be isolated from the leaves and stems of clover [1] .
|
-
- HY-137188
-
-
- HY-N4198
-
|
|
Others
|
Others
|
|
1'''-O-β-D-Glucopyranosylformoside is a Iridoids product that can be isolated from the leaves of Turpinia arguta [1].
|
-
- HY-129987
-
-
- HY-N11486
-
|
|
Others
|
Others
|
|
16β-Hydroperoxyalisol B 23-acetate is a natural product that can be isolated from Alisma orientale [1].
|
-
- HY-N1888
-
|
4beta-Carboxynortotarol
|
Others
|
Others
|
|
Rospiglioside aglycon (4beta-Carboxynortotarol) is a Miscellaneous product that can be isolated from the herbs of Conyza stricta [1].
|
-
- HY-100740C
-
|
(1α,1'S,4β)-AZD3293; (1α,1'S,4β)-LY3314814
|
Beta-secretase
|
Neurological Disease
|
|
(1α,1'S,4β)-Lanabecestat ((1α,1'S,4β)-AZD3293) a less active enantiomer of Lanabecestat. Lanabecestat is a potent, orally active and blood-brain barrier penetrating BACE1 inhibitor with a Ki of 0.4 nM [1].
|
-
- HY-W145626
-
|
beta-D-Glucopyranose 1-phosphate disodium salt
|
Biochemical Assay Reagents
|
Others
|
|
β-D-Glucopyranose 1-Phosphate Disodium Salt is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-N10378
-
|
|
Phosphatase
|
Neurological Disease
Metabolic Disease
|
|
Rubrofusarin 6-O-β-D-glucopyranoside, the glycoside of Rubrofusarin, is a protein tyrosine phosphatase 1B (PTP1B) inhibitor with the IC50 of 87.36 μM. Rubrofusarin 6-O-β-D-glucopyranoside can be used for the research of comorbid diabetes and depression [1].
|
-
- HY-N9000
-
|
|
TNF Receptor
|
Inflammation/Immunology
|
|
Loganic acid 6′-O-β-D-glucoside, a iridoidal glucoside, is isolated from the whole plant of Gentiana rhodantha (Gentianaceae). Loganic acid 6′-O-β-D-glucoside inhibits LPS-induced NO and TNF-α production in macrophage RAW264.7 cells [1].
|
-
- HY-N15362
-
|
|
Endogenous Metabolite
|
Endocrinology
|
|
5α-Pregnane-3β,17α,20α-triol is an endogenous steroid compound. 5α-Pregnane-3β,17α,20α-triol is the metabolite of Pregnenolone (HY-B0151) or Progesterone (HY-N0437). 5α-Pregnane-3β,17α,20α-triol is promising for research of the endocrine function of the placenta and the mechanisms related to steroid hormone metabolism during pregnancy [1].
|
-
- HY-161341
-
|
|
Photosensitizer
|
Cancer
|
|
β-Glucuronidase responsive conjugate 1 (compound 3) is a well-balanced photosensitizer which has photodynamic activity. β-Glucuronidase responsive conjugate 1 inhibits T-24 cell viability and growth with an IC50 of 0.2 μM. β-Glucuronidase responsive conjugate 1 can used to study bladder cancers [1].
|
-
- HY-145736A
-
|
|
Drug-Linker Conjugates for ADC
Apoptosis
|
Cancer
|
|
β-Glucuronide-dPBD-PEG5-NH2 TFA is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD.β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2 TFA, as a proagent of cIRCR201-dPBD, reduces side effects. β-Glucuronide-dPBD-PEG5-NH2 TFA can induce apoptosis and arrest cell cycle. β-Glucuronide-dPBD-PEG5-NH2 TFA has antitumor activity [1].
|
-
- HY-P2313
-
|
HβD-2
|
Antibiotic
Bacterial
|
Infection
|
|
Human β-defensin-2 (HβD-2) is a small cysteine-rich cationic skin-antimicrobial peptide (SAP) produced by a number of epithelial cells.Human β-defensin-2 has antimicrobial activity against gram-negative bacteria and Candida, but not gram-positive Staphylococcus aureus [1]. Human β-defensin-2 can be used for the study of colitis .
|
-
- HY-W145669
-
|
DE-beta-Cyd
|
Biochemical Assay Reagents
|
Others
|
|
Heptakis-(2,6-di-O-ethyl)-β-cyclodextrin is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-35094S
-
-
- HY-138089
-
|
|
Androgen Receptor
Estrogen Receptor/ERR
LDLR
|
Metabolic Disease
Cancer
|
|
17β-Hydroxy exemestane (17-H-EXE) is the primary active metabolite of Exemestane (HY-13632). 17β-Hydroxy exemestane is an aromatase inhibitor (IC50 = 69 nM) and an androgen receptor (AR) agonist (IC50 = 39.6 nM) that is selective for AR over estrogen receptor α (ERα; IC50 = 21.2 μM). 17β-Hydroxy exemestane stimulates growth of AR- and ERα-positive MCF-7 (EC50= 2.7 μM) and T47D breast cancer cells (EC50s = 0.43 and 1500 nM for AR- and ER-mediated growth, respectively) and inhibits proliferation of testosterone-treated aromatase-overexpressing MCF-7 cells. 17β-Hydroxy exemestane inhibits increases in serum cholesterol and LDL levels and prevents decreases in bone mineral density in the lumbar vertebrae and femur, as well as femoral bending strength and compressive strength of the fifth lumbar vertebrae in ovariectomized rats [1] .
|
-
- HY-107567
-
|
β-Alanylhistamine
|
Histamine Receptor
|
Neurological Disease
|
|
Alistin (Carcinine; β-Alanylhistamine) is a selective histamine H3 antagonist with antioxidant activity and neuroprotective effects on the retina of oxidatively stressed mice [1] .
|
-
- HY-W050145
-
|
1,6-Anhydro-β-D-glucopyranose; 1,6-Anhydro-β-D-glucose
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Levoglucosan (1,6-Anhydro-β-D-glucopyranose) is an anhydrosugar produced through glucan pyrolysis and is widely found in nature [1].
|
-
- HY-N3363
-
|
20(29)-Lupene-2α,3β-diol; 2α,3β-Dihydroxylup-20(29)-ene
|
Others
|
Others
|
|
Lup-20(29)-ene-2alpha,3beta-diol (20(29)-Lupene-2α,3β-diol) is a phenol product that can be isolated from Chinese bog bilberry wines [1].
|
-
- HY-152095
-
|
|
Ras
|
Cancer
|
|
PPI-GIT1/β-Pix interaction-IN-1 is a potent and orally active GIT1/β-Pix protein-protein interaction (PPI) inhibitor with a KD value of 7.7 µM. PPI-GIT1/β-Pix interaction-IN-1 disrupts the GIT/PIX interaction can impact the activation of the downstream Rho GTPase Rac1 and Cdc42. PPI-GIT1/β-Pix interaction-IN-1 inhibits metastasis of gastric cancer [1].
|
-
- HY-126839
-
C12FDG
1 Publications Verification
5-Dodecanoylaminofluorescein di-β-D-Galactopyranoside
|
Fluorescent Dye
|
Others
|
|
C12FDG (5-Dodecanoylaminofluorescein di-β-D-Galactopyranoside) is a lipophilic green fluorescent substrate for β-galactosidase detection. C12-FDG is more sensitive than FDG (HY-101895) for beta-galactosidase activity determinations in animal cells [1].
|
-
- HY-N6885
-
|
|
Others
|
Cancer
|
|
Puerarin-4'-O-β-D-glucopyranoside (compound 8) is a isoflavone from Pueraria lobata root (PLR). Puerarin-4'-O-β-D-glucopyranoside has estrogenic activity and anti-proliferation of MCF-7 human breast carcinoma cells [1].
|
-
- HY-N10411
-
|
|
Reverse Transcriptase
HIV
Xanthine Oxidase
|
Infection
Cardiovascular Disease
Cancer
|
|
Morin 3-O-β-D-glucopyranoside is a natural flavonoid with antifungal, anticancer and antioxidant activities. Morin 3-O-β-D-glucopyranoside inhibits reverse transcriptase, protein-tyrosine kinase and xanthine oxidase, and also shows anti-HIV, antiarteriosclerotic, and superoxide scavenging activities [1].
|
-
- HY-N12783
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
Digitoxigenin-3-O-β-D-quinovoside is an interleukin-2 (IL-2)/luciferase inhibitor with an IC50 value of 52 nM. Digitoxigenin-3-O-β-D-quinovoside is a cardiac lactone isolated from Elaeodendron australe var. integrifolium [1].
|
-
- HY-104004A
-
|
Fmoc-Ser-(GalNAc(Ac)3-beta-D)-OH; Fmoc-Ser[GalNAc(Ac)3-β-D]-OH; Fmoc-Ser(Ac3AcNH-β-Gal)-OH
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-Ser(O-β-D-GalNAc(OAc)3)-OH is a serine derivative [1].
|
-
- HY-N0411S4
-
|
Provitamin A-13C10; beta-Carotene-13C10
|
Isotope-Labeled Compounds
Endogenous Metabolite
Apoptosis
Reactive Oxygen Species
|
Metabolic Disease
Cancer
|
|
β-Carotene- 13C10 (Provitamin A- 13C10) is the 13C-labeled β-Carotene (HY-N0411). β-Carotene (Provitamin A), a carotenoid compound, is a naturally-occurring vitamin A precursor. β-Carotene is a modulator of reactive oxygen species (ROS), with antioxidant and antiinflammatory activities. β-Carotene may serve as an antioxidant or as a prooxidant, depending on its intrinsic properties as well as on the redox potential of the biological environment in which it acts. β-Carotene induces breast cancer cells apoptosis, with anticancer activities [1] .
|
-
- HY-137540
-
-
- HY-N0768
-
-
- HY-B1427
-
-
- HY-N2934
-
|
Betulin-3β-caffeate
|
Others
|
Others
|
|
Betulin caffeate (Betulin-3β-caffeate) is a triterpene caffeate compound [1].
|
-
- HY-N2304
-
-
- HY-N6938
-
|
|
Others
|
Infection
|
|
Pseudolaric acid B β-D-glucoside is a diterpenoid isolated from Pseudolarix kaempferi [1].
|
-
- HY-172255
-
|
|
PI4K
Apoptosis
Autophagy
PI3K
Akt
|
Cancer
|
|
PI4KIII beta inhibitor 4 (Compound 16) is a selective PI4KIIIβ inhibitor with an IC50 of 0.005 μM. PI4KIIIβ inhibitor 4 induces tumor cell apoptosis, cell cycle arrest, and autophagy by inhibiting the PI3K/AKT pathway. PI4KIIIβ inhibitor 4 can be used in the study of cancer [1].
|
-
- HY-W145687
-
|
Diosgenin-3-O-Β-D-glucuronide
|
Biochemical Assay Reagents
|
Others
|
|
Diosgenin-3-O-β-D-sodium glucuronide is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-134440A
-
|
|
P2X Receptor
|
Inflammation/Immunology
|
|
α,β-Methylene-ATP is an agonist of P2X1 and P2X3 receptors and can cross the blood-brain barrier. α,β-Methylene-ATP can trigger a reflex pressor response by activating P2X receptors in peripheral muscles and the central locus coeruleus (LC); this effect can be blocked by the P2X antagonist PPADS (HY-108960). α,β-Methylene-ATP also activates noradrenergic neurons in the central locus coeruleus, mediating antinociceptive effects; this effect can be attenuated by the locus coeruleus damaging agent DSP-4 (HY-103210/HY-121602). α,β-Methylene-ATP can be used to study the pathological mechanisms of neuropathic pain, cardiovascular reflex regulation, and antinociceptive effects of the central nervous system [1] .
|
-
- HY-N9009
-
|
|
Others
|
Others
|
|
1-Hydroxymethyl-β-carboline glucoside (Compound 13) is a natural product that can be isolated from Picrasma quassioides [1].
|
-
- HY-W416222
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Methyl β-D-glucuronide sodium is a kind of biological materials or organic compounds that are widely used in life science research [1].
|
-
- HY-N8675
-
|
|
Others
|
Others
|
|
Olivil-4'-O-β-glucopyranoside (Compound 2) is a lignin derived from Jasminum tortuosum stems [1].
|
-
- HY-139671
-
-
- HY-136344
-
|
|
Drug Metabolite
|
Others
|
|
Simvastatin Acyl-β-D-glucuronide is a metabolite of Simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM [1] .
|
-
- HY-137963
-
-
- HY-15926
-
ONPG
4 Publications Verification
2-Nitrophenyl β-D-galactopyranoside
|
Biochemical Assay Reagents
|
Others
|
|
ONPG is a colorimetric and spectrophotometric substrate for detection of β-galactosidase activity.
|
-
- HY-12956B
-
|
Prostaglandin F2β; PGF2β
|
Endogenous Metabolite
|
Others
|
|
(5R)-Dinoprost is a metabolite produced by cyclooxygenase metabolism of arachidonic acid. (5R)-Dinoprost (Prostaglandin F2β) induces dose-dependent release of hexose containing mucin [1] .
|
-
- HY-N13015
-
|
|
Endogenous Metabolite
|
Others
|
|
Quercetin 5-O-β-D-glucopyranoside is a flavonoid, which can be isolated from the cocoon shell of silkworm (Bombyx mori). Quercetin 5-O-β-D-glucopyranoside is found in some plants, and its discovery in silkworm cocoons indicates its unique role in insect metabolism [1].
|
-
- HY-126393
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Carboxymethyl-β-cyclodextrin, 99% is a cationic cyclodextrin used as a carrier for drugs. It has been shown to bind nonsteroidal anti-inflammatory drugs (NSAIDs) with high affinity and selectivity.
|
-
- HY-W337897
-
-
- HY-P3017
-
|
CtXyn11A; EC 3.2.1.8
|
Poly(ADP-ribose) Glycohydrolase (PARG)
|
Others
|
|
Endo-1,4-β-xylanase (Xylanase) is an arabinoxylan (AX) degrading enzyme and a glycoside hydrolase, is often used in biochemical studies. Endo-1,4-β-xylanase cleaves the β-xylosidic bond between two d-xylopyranosyl residues linked in β-(1,4) [1].
|
-
- HY-W141862
-
-
- HY-118583A
-
|
β-(4-Fluorophenyl)-GABA hydrochloride; F-Phenibut hydrochloride
|
Drug Derivative
|
Neurological Disease
|
|
4-Fluoro phenibut (β-(4-Fluorophenyl)-GABA) hydrochloride is a Gabapentinoid and is structurally similar to known nootropics [1].
|
-
- HY-137853
-
|
|
Fluorescent Dye
|
Others
|
|
4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-Glucopyranoside is a fluorogenic substrate for N-acetyl-β-D-glucosaminidase [1].
|
-
- HY-137912S1
-
-
- HY-P990301
-
|
|
Amyloid-β
|
Others
|
|
Anti-Human/Mouse/Rat Amyloid-beta Antibody (MOAB-2) is a mouse-derived IgG2b, λ type antibody inhibitor, targeting to Amyloid-beta.
|
-
- HY-113602
-
|
Antibiotic 273 A1-beta
|
Antibiotic
Bacterial
|
Infection
|
|
Paldimycin B (Antibiotic 273 A1-beta) is a powerful semi-synthetic antibiotic with antibacterial activity against S. aureus and coagulase-negative staphylococci [1].
|
-
- HY-N6605
-
|
Trifolin
|
Apoptosis
|
Cardiovascular Disease
Cancer
|
|
Kaempferol 3-O-β-D-galactopyranoside (Trifolin) is an orally active flavonoid derivative that can be found in the aerial parts of Consolida oliverana. Kaempferol 3-O-β-D-galactopyranoside exhibits antitumor and cardioprotective effects [1] .
|
-
- HY-N12521
-
|
|
Others
|
Inflammation/Immunology
|
|
(3β,24S)-3-Hydroxystigmast-5-en-7-one (Compound 31) is a compound that can be isolated from Lindera akoensis . (3β,24S)-3-Hydroxystigmast-5-en-7-one has anti-inflammatory activity [1].
|
-
- HY-W700460
-
|
|
Biochemical Assay Reagents
|
|
|
9-β-D-Arabinofuranosyl-2-fluorohypoxanthine is a nucleoside analog with activity as an inhibitor of certain enzymes. 9-β-D-Arabinofuranosyl-2-fluorohypoxanthine is useful in synthesis and, due to its structural changes, is able to cause base mispairing, thereby stopping chain polymerization reactions.
|
-
- HY-50900
-
|
Amyloid-β production inhibitor; γ-Secretase Modulators
|
Amyloid-β
|
Neurological Disease
|
|
gamma-Secretase Modulators (Amyloid-β production inhibitor) is a Amyloid-β production inhibitor.
|
-
- HY-154654
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
9-(2-β-C-Methyl-2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)purine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc [1].
|
-
- HY-W585920
-
|
|
FXR
|
Metabolic Disease
|
|
Chenodeoxycholic acid 24-acyl-β-D-glucuronide is a metabolite of Chenodeoxycholic Acid (HY-76847) [1].
|
-
- HY-N7867
-
|
|
Others
|
Others
|
|
Taxifolin 3 '-O-β-D-glucoside is a flavonoid compound isolated from Averrhoa carambola [1].
|
-
- HY-168425
-
-
- HY-N6879
-
|
|
Others
|
Metabolic Disease
|
|
DiosMetin 7-O-β-D-Glucuronide is an antioxidant constituent in the fruits of Luffa cylindrical [1].
|
-
- HY-137268
-
-
- HY-137946
-
|
|
Aminopeptidase
|
Others
|
|
L-Leucine 4-methoxy-β-naphthylamide hydrochloride is an aminopeptidase M and leucine aminopeptidase substrate [1].
|
-
- HY-N11495
-
-
- HY-N9408
-
|
|
Others
|
Others
|
|
Furostan, β-D-glucopyranoside deriv (compound 2) is a oligofurostanoside that can be found in Asparagus cochinchinensis.
|
-
- HY-168924
-
|
|
Wnt
β-catenin
|
Metabolic Disease
|
|
Wnt/β-catenin activator 1 (Compound 5m) is the orally active activator for Wnt/β-catenin signaling pathway, that arrests cell cycle at G1 phase, inhibits early proliferation of adipocytes, and inhibits adipogenesis in cell 3T3-L1 with an IC50 of 330 nM. Wnt/β-catenin activator 1 exhibits anti-adipogenic and anti-dyslipidemic activities in high-fat diet fed Syrian golden hamster model [1].
|
-
- HY-43470
-
-
- HY-W142906
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Methyl β-D-Arabinopyranoside is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-P3170
-
|
|
Biochemical Assay Reagents
|
Others
|
|
β-Alanine-pyruvate transaminase is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W145651
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Isopropyl β-D-thioglucopyranoside is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-N1626
-
|
|
Others
|
Others
|
|
1β-Hydroxy-2-oxopomolic acid is a compound isolated from methanolic extract of leaves of Eriobotrya deflexa [1].
|
-
- HY-W738314
-
|
|
Biochemical Assay Reagents
|
|
|
Heptakis(6-O-tert-butyldimethylsilyl)-β-cyclodextrin tetradecaacetate is a chemically modified cyclodextrin with good cosolvent activity. Heptakis(6-O-tert-butyldimethylsilyl)-β-cyclodextrin tetradecaacetate is widely used in compound formulations to improve the solubility and bioavailability of compounds. Heptakis(6-O-tert-butyldimethylsilyl)-β-cyclodextrin tetradecaacetate helps improve the release characteristics of compounds.
|
-
- HY-146989S
-
-
- HY-P990160
-
|
|
CD3
|
Others
|
|
Anti-Rat TCR alpha/beta Antibody (R73) is a mouse-derived IgG1, κ type antibody inhibitor, targeting to rat TCR alpha/beta.
|
-
- HY-142119S
-
-
- HY-145781
-
|
|
Drug Intermediate
|
Metabolic Disease
|
|
β-L-Fucopyranosyl phosphate can be used for the research of carbohydrate metabolism. Glycosyl phosphates play crucial roles in carbohydrate metabolism as metabolic regulators or ubiquitous intermediates for glycoconjugate biosynthesis [1].
|
-
- HY-P1866
-
|
|
Opioid Receptor
|
Neurological Disease
|
|
β-Endorphin, equine is an endogenous opioid peptide, which binds at high affinity to both μ/δ opioid receptors [1] . Analgesic properties .
|
-
- HY-E70048
-
|
Gb4 synthetase
|
Others
|
Others
|
|
beta-1,3-N-Acetylgalactosaminyltransferase (LgtD) (Gb4 synthetase) expressed by mature/activated B cells [1].
|
-
- HY-W554423
-
-
- HY-W129394
-
|
|
Biochemical Assay Reagents
|
Others
|
|
6-Amino-6-deoxy-β-cyclodextrin is a cyclodextrin derivative that can be used to prepare other cyclodextrin derivatives. 6-Amino-6-deoxy-β-cyclodextrin can also be used as a chiral selector for chiral separation of α-amino acid derivatives by capillary electrophoresis [1].
|
-
- HY-N12865
-
|
|
Others
|
Others
|
|
Protocatechuic acid 3-O-β-D-glucopyranoside is produced from the hairy root culture of Lobelia sessilifolia supplemented with Protocatechuic acid (HY-N0294). Protocatechuic acid 3-O-β-D-glucopyranoside is potent for the production of new phenol glycosides which could be applied in natural chemistry, biochemistry and pharmacognosy [1]
|
-
- HY-137201
-
|
2-Phenylethyl 1-thio-β-D-galactoside
|
Biochemical Assay Reagents
|
Others
|
|
2-Phenylethyl β-D-thiogalactoside is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-116285S1
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
1-O-n-Octyl-β-D-glucopyranoside-d17 is the deuterium labeled n-Octyl β-D-glucopyranoside[1]. n-Octyl-β-d-glucopyranoside is a non-ionic detergent, it can be widely used in the research of biotechnical, biochemical applications, solubilization and crystallization of membrane proteins[2][3].
|
-
- HY-W011792
-
|
2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose
|
Biochemical Assay Reagents
|
Others
|
|
Diacetone-β-D-fructose is a biochemical reagent that can be used as a biological material or organic compound for life science related research [1].
|
-
- HY-N10441
-
|
|
Parasite
|
Infection
|
|
3β-Hydroxy-hop-22(29)-ene (compound 3) is a potent antiparasitic agent. 3β-Hydroxy-hop-22(29)-ene shows moderate activity against Trypanosoma cruzi and Leishmania mexicana [1].
|
-
- HY-150159S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Cotinine-d3 N-β-D-Glucuronide is the deuterium labeled Cotinine-d3 N-β-D-Glucuronide. Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified [1].
|
-
- HY-P5603
-
|
BNBD-12
|
Bacterial
|
Infection
|
|
Bovine neutrophil beta-defensin 12 is an antimicrobial peptide derived from bovine neutrophils, which has antibacterial activity against Escherichia coli and Staphylococcus aureus [1].
|
-
- HY-120201S
-
-
- HY-N4055
-
|
Lup-20(29)-ene-3β,30-diol; Wallichenol
|
Others
|
Others
|
|
Hennadiol (Lup-20(29)-ene-3β,30-diol) is a product that can be isolated from [1].
|
-
- HY-141929S
-
-
- HY-134448
-
-
- HY-N8011
-
|
|
Others
|
Others
|
|
25(R)-3β,17α-Dihydroxy-5α-spirostan-6-one 3-O-α-D-rhamnopyranosyl-(1→2)-β-D-glucopyranoside is a compound that can be isolated from Lilium brownii var. viridulum [1].
|
-
- HY-168361
-
-
- HY-118774
-
-
- HY-N11988
-
|
|
Others
|
Others
|
|
Nortrachelogenin 5'-C-β-glucopyranoside (compound 3) is a glycoside compound that can be isolated from the aerial parts of Trachelospermia vine [1].
|
-
- HY-137276
-
|
Bluo-Gal
|
Fluorescent Dye
Glycosidase
|
Others
|
|
5-Bromo-3-indolyl β-D-galactopyranoside (Bluo-Gal) is a chromogenic substrate for β-galactosidase. 5-Bromo-3-indolyl β-D-galactopyranoside is hydrolyzed by the enzyme to generate a 5-bromoindole intermediate, which is further oxidized to form an insoluble blue precipitate. 5-Bromo-3-indolyl β-D-galactopyranoside can specifically recognize bacterial β-galactosidases (such as the product of the Escherichia coli lacZ gene) and reacts at pH 7.4, making it suitable for light and electron microscopic observations. 5-Bromo-3-indolyl β-D-galactopyranoside can be used in histochemical detection of reporter gene expression in transgenic organisms, such as the localization analysis of β-galactosidase activity in mouse embryos or muscle tissues [1] .
|
-
- HY-N12860
-
|
|
Others
|
Others
|
|
Gossypetin 3-O-β-D-glucopyranoside is a flavonol that can be isolated from Hibiscus sabdarifla [1].
|
-
- HY-138089S
-
-
- HY-P10094
-
|
|
Fluorescent Dye
|
Others
|
|
β-Ala-Gly-Arg-pNA is a chromogenic substrate of thrombin with pNA a strong absorbance at 405 nm [1].
|
-
- HY-N6260
-
|
|
Others
|
Others
|
|
4-O-beta-Glucopyranosyl-cis-coumaric acid is a natural compound isolated formn Nelumbo nucifera Gaertn.
|
-
- HY-W128203
-
-
- HY-P2869I
-
|
|
Others
|
Others
|
|
β-D-Galactosidase, Sweet almond is one of the most studied enzymes in term of its immobilisation [1].
|
-
- HY-168793
-
-
- HY-N15233
-
|
|
Others
|
Others
|
|
Demethylflavasperone 10-O-β-D-glucopyranoside is a glycoside compound found in the stem of Berchemia racemosa [1].
|
-
- HY-N10669
-
|
|
Others
|
Metabolic Disease
|
|
Apigenin 4′-O-β-D-glucopyranoside is a flavonoid that can be found in caledonian guioa villosa [1].
|
-
- HY-W277691
-
-
- HY-N6006R
-
|
|
Others
|
Others
|
|
1,3,6-Tri-O-galloyl-beta-D-glucose (Standard) is the analytical standard of 1,3,6-Tri-O-galloyl-beta-D-glucose. This product is intended for research and analytical applications. 1,3,6-Tri-O-galloyl-beta-D-glucose (1,3,6-Tri-O-galloyl-β-D-glucose) is a phenolic compound in Black Walnut Kernels [1].
|
-
- HY-137823
-
|
|
Endogenous Metabolite
|
Cancer
|
|
4-Nitrophenyl-N-acetyl-β-D-galactosaminide has inhibitory activity against GlcNAc and GalNAc with Kis of 1.15 mM and 0.51 mM, respectively. 4-Nitrophenyl-N-acetyl-β-D-galactosaminide is extracted from Trichomonas foetus (T. foetus) [1]
|
-
- HY-W007648
-
|
β-Alanine methyl ester hydrochloride
|
Drug Intermediate
Biochemical Assay Reagents
|
Others
|
|
Methyl 3-aminopropanoate (β-Alanine methyl ester) hydrochloride is a compound prepared by esterification of Β-Alanine (I). Methyl 3-aminopropanoate hydrochloride can be used in the synthesis of bidentate pyridine-acid ligand. Methyl 3-aminopropionate hydrochloride can be used for proteomics research [1] .
|
-
- HY-N10776
-
|
|
HIV
|
Infection
|
|
Kaempferol-3-O-(6′′-galloyl)-β-glucopyranoside is a glucopyranoside. Kaempferol-3-O-(6′′-galloyl)-β-glucopyranoside inhibts HIV-2 RNase H with an IC50 value of 5.19 μM [1].
|
-
- HY-D1633
-
|
|
Fluorescent Dye
|
Others
|
|
4-Methylumbelliferyl-β-D-galactopyranoside 6-sulfate is a fluorescent dye. 4-Methylumbelliferyl-β-D-galactopyranoside 6-sulfate can be used in the diagnosis of mucopolysaccharidosis IV A by detecting activity of galactose-6-sulphate sulphatase [1] .
|
-
- HY-W060316
-
|
3-Hydroxy-5-isopropyltropolone
|
HBV
DNA/RNA Synthesis
|
Infection
|
|
β-Thujaplicinol (3-Hydroxy-5-isopropyltropolone) is an inhibitor of hepatitis B virus (HBV) ribonuclease H. β-Thujaplicinol inhibits RNAseHs of HBV genotypes D and H with IC50 values of 5.9 and 2.3 μM, respectively [1].
|
-
- HY-D1633A
-
|
|
Fluorescent Dye
|
Others
|
|
4-Methylumbelliferyl-β-D-galactopyranoside 6-sulfate sodium is a fluorescent dye. 4-Methylumbelliferyl-β-D-galactopyranoside 6-sulfate sodium can be used in the diagnosis of mucopolysaccharidosis IV A by detecting activity of galactose-6-sulphate sulphatase [1] .
|
-
- HY-152478
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
3’-β-C-Ethynylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) [1]. 3’-β-C-Ethynylguanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-130448
-
|
|
Prostaglandin Receptor
ROCK
|
Cardiovascular Disease
|
|
8-iso Prostaglandin F1β is an isoprostane, that exhibits vasoconstrictive effect in neonatal porcine pulmonary arteries, pulmonary veins, and mesenteric arteries. 8-iso Prostaglandin F1β targets TXA2 receptor and exhibits the blood vessel contractile efficacy under the influence of tyrosine kinase and Rho kinase [1].
|
-
- HY-N15155
-
|
Vitexin 7-glucoside
|
Others
|
Metabolic Disease
|
|
Vitexin 7-O-β-D-glucopyranoside (Vitexin 7-glucoside) is a flavone glycoside found in Beta vulgaris var. cicla. Vitexin 7-O-β-D-glucopyranoside shows a hepatoprotective activity in primary cultured rat hepatocytes with Carbon tetrachloride (CCl4) (HY-Y0298)-induced cell toxicity [1].
|
-
- HY-W317473
-
-
- HY-W747445
-
-
- HY-N0981
-
|
|
Others
|
Others
|
|
1,2-O-Isopropylidene-beta-D-fructopyranose is a natural product [1].
|
-
- HY-W700451
-
-
- HY-167577
-
-
- HY-N2054
-
|
Kaempferol 4'-β-glucoside
|
Others
|
Others
|
|
Kaempferol 4'-glucoside (Kaempferol 4'-β-glucoside) is a flavonol glycoside.
|
-
- HY-N9813
-
|
|
Others
|
Others
|
|
1-(3,4,5-Trihydroxypentanoyl)-β-carboline is a natural product [1].
|
-
- HY-W743744
-
-
- HY-W145501
-
|
Trimethyl-beta-cyclodextrin
|
Biochemical Assay Reagents
|
Others
|
|
Heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-N8132
-
|
|
Reactive Oxygen Species
|
Inflammation/Immunology
|
|
2,4,6-Trichlorol-3-methyl-5-methoxy-phenol 1-O-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside is a chlorophenyl glycoside found in the bulbs of Lilium brownie var. viridulum. 2,4,6-Trichlorol-3-methyl-5-methoxy-phenol 1-O-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside exhibits weak inhibition of NO production in LPS-stimulated RAW 264.7 cells [1].
|
-
- HY-126194
-
|
Ro 61-1448
|
Drug Metabolite
|
Others
|
|
Tolcapone 3-β-D-glucuronide (Ro 61-1448) is an O-methyl metabolite and the glucuronide metabolite of Tolcapone (Ro 40-7592; HY-17406). Tolcapone 3-β-D-glucuronide is pharmacologically inactive [1].
|
-
- HY-137869
-
|
5-Bromo-6-chloro-3-indolyl β-D-glucuronide cyclohexylammonium
|
Biochemical Assay Reagents
|
Others
|
|
Magenta-β-D-GlcA is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-N13014S2
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Indole-3-acetyl β-D-glucopyranose-d4 is deuterium labeled Indole-3-acetyl β-D-glucopyranose. Indole-3-acetyl β-D-glucopyranose is a glucose esterified derivative of the plant hormone indole-3-acetic acid (IAA). Indole-3-acetyl β-D-glucopyranose is involved in regulating plant growth and can be used to study the metabolism and regulatory mechanisms of plant hormones [1] .
|
-
- HY-N1646
-
|
2β,16α-dihydroxy-ent-kaurane 2-O-β-D-allopyranoside
|
Others
|
Others
|
|
2,16-Kauranediol 2-O-β-D-allopyranoside (compound 26) is a natural product that can be isolated from the air-dried fronds of Pteris cretica [1].
|
-
- HY-N10847
-
|
|
Others
|
Cancer
|
|
1-O-Acetyl-6beta-O-Isobutyrylbritannilactone (compound 5), a sesquiterpene lactone, can be isolated from the flowers of Inula britannica. 1-O-Acetyl-6beta-O-Isobutyrylbritannilactone shows significant cytotoxicity to tumor cells [1].
|
-
- HY-145519
-
|
|
Fluorescent Dye
|
Neurological Disease
|
|
Mu-6S-Palm-β-Glc is a fluorogenic substrate for palmitoyl-protein thioesterase (PPT). Mu-6S-Palm-β-Glc can be used for the research of neuronal ceroid lipofuscin disease in infants [1] .
|
-
- HY-P5906
-
|
Citrullinated Aβ (1-40); Citrullinated Aβ40
|
Amyloid-β
|
Neurological Disease
|
|
Citrullinated amyloid-β (1-40) peptide (human) (Citrullinated Aβ (1-40)) is a modified form of β-Amyloid (1-40) (HY-P0265) with a citrullination at the Arg5 site. Citrullinated amyloid-β (1-40) peptide (human) exhibits increased transient formation of soluble oligomers and insoluble aggregates composed of distorted parallel β-sheets compared with unmodified β-Amyloid (1-40) [1].
|
-
- HY-172256
-
|
|
PI4K
|
Cancer
|
|
PI4KIII beta inhibitor 5 is a PI4KIIIβ inhibitor with an IC50 of 19 nM. PI4KIII beta inhibitor 5 can induce cancer cell apoptosis (Apoptosis), cell cycle arrest at the G2/M phase, and autophagy (Autophagy) by inhibiting the PI3K/AKT pathway. PI4KIII beta inhibitor 5 has also demonstrated significant antitumor activity in the H446 xenograft model of small cell lung cancer. PI4KIII beta inhibitor 5 can be used for research in the field of cancer therapy [1].
|
-
- HY-P3187
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Exo-1,4-β-xylosidase is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W145621
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Gal[2346Bn]-β-SPh is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
![Gal[2346Bn]-β-SPh](//file.medchemexpress.com/product_pic/hy-w145621.gif)
- HY-152806
-
|
|
Nucleoside Antimetabolite/Analog
|
Others
|
|
2-Amino -6-chloro-9-(2-β-C-methyl-β-D-ribofuranosyl)-9H-purine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc [1].
|
-
- HY-152974
-
-
- HY-N13524
-
|
|
Others
|
Others
|
|
Solagenin 6-O-β-D-quinovopyranoside is a steroid product that can be isolated from Solanum torvum [1].
|
-
- HY-P0265F
-
|
|
Amyloid-β
|
Others
|
|
Biotin-Ahx-β-Amyloid (1-40) is a biological active peptide. (Biotin labled HY-P0265)
|
-
- HY-N1576
-
|
|
Others
|
Others
|
|
p-Vinylphenyl O-beta-D-glucopyranoside is a Phenols product that can be isolated from the herbs of Pteris vittata [1].
|
-
- HY-N8204
-
-
- HY-N13502
-
|
|
Others
|
Others
|
|
Neochlorogenin 6-O-β-D-quinovopyranoside is a Triterpene product that can be isolated from Solanum torvum [1].
|
-
- HY-79404A
-
|
|
Amino Acid Derivatives
|
Others
|
|
Boc-beta-t-butyl-d-alanine is an intermediate, can be used in the synthesis of peptides and other amino acids [1].
|
-
- HY-N8639
-
|
|
Others
|
Others
|
|
Chrysin 8-C-β-D-glucoside is a natural compound isolated from the herbs of Psidium guajava [1].
|
-
- HY-N1528
-
|
|
Others
|
Others
|
|
Quinovic acid 3-O-β-D-quinovopyranoside is a tritenpenoid glycoside, that can be isolated from the bark of L. hexandra [1].
|
-
- HY-N4088
-
|
|
Fungal
|
Infection
Endocrinology
|
|
Pseudolaric acid A-O-β-D-glucopyranoside, isolated from Cortex Pseudolaricis, demonstrates antifungal and antifertility activities [1].
|
-
- HY-N10693
-
|
|
Others
|
Others
|
|
Protoapigenin 4′-O-β-D-glucoside is a flavonoid glycoside, that can be isolated from Thelypteris torresiana [1].
|
-
- HY-N15425
-
-
- HY-137908
-
|
|
Prostaglandin Receptor
|
Others
|
|
11β-Misoprostol is one of several impurities which are possible in the production of Misoprostol. Misoprostol is a 15-deoxy-l6-hydroxy-l6-methyl analog of prostaglandin El (PGE1) [1].
|
-
- HY-P4788
-
|
|
Amyloid-β
|
Neurological Disease
|
|
Acetyl-Amyloid β-Protein (1-6) amide is a hexapeptide that contains a potential copper(II) binding site. Acetyl-Amyloid β-Protein (1-6) amide can be used for research of Alzheimer's disease and related disorders [1].
|
-
- HY-W002327S1
-
-
- HY-N8971
-
|
16α-Hydroxybauerenol
|
Bacterial
|
Infection
|
|
Bauer-7-ene-3β,16α-diol, a triterpenoid, is a natural product that can be isolated from dried flower buds of Tussilago farfara L. or Petasites tricholobus (Compositae). Bauer-7-ene-3β,16α-diol shows medium antibacterial activity against E. coli [1].
|
-
- HY-W006443
-
|
2,3,4,6-Tetra-O-acetyl-&beta
|
Biochemical Assay Reagents
|
Others
|
|
2,3,4,6-Tetra-O-acetyl-β-D-glucopyranosyl trichloroacetimidate, 98%(N) (2,3,4,6-Tetra-O-acetyl-&beta) can be used in glycobiology research.
|
-
- HY-N11441
-
|
|
Phosphatase
|
Metabolic Disease
|
|
cis-Ferulic acid 4-O-β-D-glucopyranoside (compound 7) is a phenolic glycosid, which can be isolated from Nitraria sibirica.. cis-Ferulic acid 4-O-β-D-glucopyranoside exhibits antioxidant activity and potent inhibitory effect on Phosphatase PTP1B [1].
|
-
- HY-P5905
-
|
Citrullinated Aβ (1-42); Citrullinated Aβ42
|
Amyloid-β
|
Neurological Disease
|
|
Citrullinated amyloid-β (1-42) peptide (human) (Citrullinated Aβ (1-42)) is a modified form of β-Amyloid (1-42) (HY-P1363) with a citrullination at the Arg5 site. Compared to the unmodified β-Amyloid (1-42), its formation of soluble low-molecular-weight oligomers is enhanced, the rate of fibril formation is reduced, and like unmodified Aβ42, it forms protofibrils comprised of parallel β-sheets [1].
|
-
- HY-P2291
-
|
|
Bacterial
|
Inflammation/Immunology
|
|
Beta-defensin 103 isoform X1, pig is an antimicrobial peptide found in different living organisms, involved in the first line of defense in their innate immune response against pathogens [1].
|
-
- HY-W882667
-
|
|
iGluR
|
Neurological Disease
|
|
Pregn-5-en-3β-ol, a steroid compound, when formulated as the biscarboxylic acid hemiesters along with androst-5-en-3β-ol, serves as a potent positive allosteric modulator of NMDA (N-methyl-D-aspartate) receptors, making it applicable for research into psychiatric disorders [1].
|
-
- HY-137494
-
|
|
GABA Receptor
|
Neurological Disease
|
|
Ethyl β-carboline-3-carboxylate (fl-CCE) is a ligand and short-acting antagonist of benzodiazepine receptors. Ethyl β-carboline-3-carboxylate did not affect cerebellar cGMP levels when used alone, but when taken together with Diazepam, it significantly inhibited the cGMP levels that were upregulated by Diazepam [1].
|
-
- HY-W415807
-
-
- HY-N7898
-
|
Simplocosin
|
Others
|
Others
|
|
Epipinoresinol-4'-O-β-D-glucoside (Simplocosin) is a glucoside compound [1].
|
-
- HY-W141801
-
-
- HY-N13337
-
|
|
Others
|
Others
|
|
threo-Guaiacylglycerol-beta-O-4'-dehydrodisinapyl ether is a natural product [1].
|
-
- HY-112502B
-
|
Adenosine 5'-(α,β-methylene)diphosphate sodium
|
CD73
|
Cancer
|
|
MethADP (sodium salt) (Adenosine 5'-(α,β-methylene)diphosphate (sodium)) is a specific CD73 inhibitor.
|
-
- HY-W357132
-
-
- HY-W152862S
-
|
Alpha-cyano-3-phenoxybenzyl [1R-[1alpha(R*),3beta]]-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate-d5
|
Isotope-Labeled Compounds
|
Others
|
|
Beta-cypermethrin-d5 (Alpha-cyano-3-phenoxybenzyl [1R-[1alpha(R*),3beta]]-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate-d5) is deuterium labeled Beta-cypermethrin [1].
|
-
- HY-D2280
-
|
|
HDAC
Estrogen Receptor/ERR
|
Others
|
|
Estrogen receptor β/HDAC probe 1 (compound P1) is a near-infrared fluorescent probe that dual-targets the estrogen receptor (Estrogen Receptor/ERR) β/histone deacetylase HDAC [1].
|
-
- HY-165664S
-
|
Glyceol 2-Phosphate-d5 sodium salt hydrate
|
Isotope-Labeled Compounds
|
Others
|
|
β-Glycerophosphate-d5 (Glyceol 2-Phosphate-d5) sodium salt hydrateis deuterium labeled β-Glycerophosphate (sodium salt hydrate) [1].
|
-
- HY-N9452
-
|
|
Others
|
Others
|
|
Capsaicin β-D-glucopyranoside is a glucoside converted by Capsaicin. Capsaicin is the active ingredient of chili peppers and gives them the characteristic pungent flavor [1] .
|
-
- HY-135103
-
|
T-βMCA sodium
|
FXR
|
Cancer
|
|
Tauro-β-muricholic Acid sodium (T-βMCA sodium), a endogenous metabolite, is a competitive and reversible farnesoid X receptor (FXR) antagonist, with an IC50 of 40 μM [1] .
|
-
- HY-W010452
-
|
β-Hydroxybutyric acid sodium
|
Endogenous Metabolite
|
Metabolic Disease
|
|
3-Hydroxybutyric acid sodium (β-Hydroxybutyric acid sodium) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid sodium can modulate the properties of membrane lipids [1].
|
-
- HY-113378
-
|
β-Hydroxybutyric acid
|
Endogenous Metabolite
|
Metabolic Disease
|
|
3-Hydroxybutyric acid (β-Hydroxybutyric acid) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid can modulate the properties of membrane lipids [1].
|
-
- HY-W704091
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
α-Amino-β-methylaminopropionic acid-d3 hydrochloride is the deuterium labeled α-Amino-β-methylaminopropionic acid. Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified [1].
|
-
- HY-148682
-
|
Glycyrrhetic acid 3-O-hydrogen sulfate
|
OAT
11β-HSD
Drug Metabolite
|
Metabolic Disease
Inflammation/Immunology
|
|
18β-Glycyrrhetyl-3-O-sulfate (Glycyrrhetic acid 3-O-(hydrogen sulfate)) is a potent type 2 11β-hydroxysteroid dehydrogenase (11β-HSD2) inhibitor with an IC50 of 0.10 µM using rat kidney microsome. 18β-Glycyrrhetyl-3-O-sulfate is the major metabolite of Glycyrrhetinic acid (GA). 18β-Glycyrrhetyl-3-O-sulfate is the substrate of organic anion transporter (OAT) 1 and OAT3. 18β-Glycyrrhetyl-3-O-sulfate has anti-inflammatory effects and has the potential for pseudohyperaldosteronism research [1] .
|
-
- HY-B0927
-
|
(-)-β-Hydrastine; (1R,9S)-β-Hydrastine
|
Tyrosine Hydroxylase
Dopamine Receptor
OAT
|
Neurological Disease
|
|
Hydrastine ((-)-β-Hydrastine; (1R,9S)-β-Hydrastine) is a selective competitive inhibitor of tyrosine hydroxylase (TH), inhibiting dopamine biosynthesis (IC50=20.7 μM, PC12 cells). Hydrastine also inhibits the organic cation transporter OCT1 (IC50=6.6 μM). Hydrastine may cause neuronal toxicity through mitochondrial dysfunction rather than oxidative stress damage, and can aggravate cell apoptosis when combined with L-DOPA. Hydrastine can be used to study Parkinson's disease-related dopaminergic neuronal damage [1] .
|
-
- HY-108652
-
|
|
P2X Receptor
|
Inflammation/Immunology
|
|
α,β-Methylene-ATP trisodium is an agonist of P2X1 and P2X3 receptors and can cross the blood-brain barrier. α,β-Methylene-ATP trisodium can trigger a reflex pressor response by activating P2X receptors in peripheral muscles and the central locus coeruleus (LC); this effect can be blocked by the P2X antagonist PPADS (HY-108960). α,β-Methylene-ATP trisodium also activates noradrenergic neurons in the central locus coeruleus, mediating antinociceptive effects; this effect can be attenuated by the locus coeruleus damaging agent DSP-4 (HY-103210/HY-121602). α,β-Methylene-ATP trisodium can be used to study the pathological mechanisms of neuropathic pain, cardiovascular reflex regulation, and antinociceptive effects of the central nervous system [1] .
|
-
- HY-134440
-
|
|
P2X Receptor
|
Inflammation/Immunology
|
|
α,β-Methylene-ATP dilithium is an agonist of P2X1 and P2X3 receptors and can cross the blood-brain barrier. α,β-Methylene-ATP dilithium can trigger a reflex pressor response by activating P2X receptors in peripheral muscles and the central locus coeruleus (LC); this effect can be blocked by the P2X antagonist PPADS (HY-108960). α,β-Methylene-ATP dilithium also activates noradrenergic neurons in the central locus coeruleus, mediating antinociceptive effects; this effect can be attenuated by the locus coeruleus damaging agent DSP-4 (HY-103210/HY-121602). α,β-Methylene-ATP dilithium can be used to study the pathological mechanisms of neuropathic pain, cardiovascular reflex regulation, and antinociceptive effects of the central nervous system [1] .
|
-
- HY-136329
-
|
|
ADC Linker
|
Cancer
|
|
β-D-glucuronide-pNP-carbonate is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].
|
-
- HY-N12841
-
|
|
Others
|
Others
|
|
Limocitrin 7-O-β-D-glucopyranoside is a flavonoid glycoside, which is initially isolated from Sedum acre [1].
|
-
- HY-N15222
-
|
|
Others
|
Others
|
|
Toralactone-9-O-β-D-glucopyranoside is a phenolic component that can be isolated from Eriocaulon buergerianum [1].
|
-
- HY-N11770
-
|
|
Others
|
Others
|
|
Rhamnetin 3-O-β-D-glucopyranoside is a flavonoid, that can be isolated from the roots of Polygala sibirica L. (Polygalaceae) [1].
|
-
- HY-N1526
-
|
|
Others
|
Others
|
|
Quinovic acid 3-O-beta-D-glucoside is a Triterpenoids product that can be isolated from the herbs of Luculia pincia [1].
|
-
- HY-N1533
-
|
|
PAI-1
|
Inflammation/Immunology
|
|
28-O-β-D-Glucopyranosyl pomolic acid is a urokinase plasminogen activator inhibitor with IC50 at 37.82 μM [1].
|
-
- HY-N2107
-
-
- HY-152447
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
3’-beta-C-Ethynyl inosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc [1]. 3’-beta-C-Ethynyl inosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-152625
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
2’-Beta-C-Ethynyl inosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc [1]. 2’-Beta-C-Ethynyl inosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-W615108B
-
|
NMNH, reduced form disodium
|
Endogenous Metabolite
|
Cancer
|
|
β-Nicotinamide mononucleotide, reduced form disodium (β-NMN) is the oxidized form of NAD+ precursor and is a NAD+ enhancer. β-Nicotinamide mononucleotide, reduced form disodium can be reduced to dihydronicotinamide mononucleotide (NMNH). NMNH inhibits glycolysis, TCA cycle, and cell growth [1].
|
-
- HY-N9397R
-
|
|
Others
|
Metabolic Disease
|
|
Quercetin 3-O-(6''-O-malonyl)-β-D-glucoside (Standard) is an analytical standard for Quercetin 3-O-(6''-O-malonyl)-β-D-glucoside. This product is intended for research and analytical applications. Quercetin 3-O-(6''-O-malonyl)-β-D-glucoside is a flavonol glycoside. Quercetin 3-O-(6''-O-malonyl)-β-D-glucoside has antioxidant activity.
|
-
- HY-W777640
-
|
|
Biochemical Assay Reagents
|
|
|
6-Hexadecanoylamino-4-methylumbelliferyl β-D-galactopyranoside is a specific fluorescent substrate with the function of detecting galactosidase activity. 6-Hexadecanoylamino-4-methylumbelliferyl β-D-galactopyranoside can be used in biomedical research to observe the efficiency of enzyme-catalyzed reactions. 6-Hexadecanoylamino-4-methylumbelliferyl β-D-galactopyranoside is also widely used in the analysis of polysaccharides and carbohydrate enzymology.
|
-
- HY-N2451R
-
|
|
Phosphatase
|
Metabolic Disease
Endocrinology
|
|
Aloe-emodin-8-O-β-D-glucopyranoside (Standard) is the analytical standard of Aloe-emodin-8-O-β-D-glucopyranoside. This product is intended for research and analytical applications. Aloe-emodin-8-O-β-D-glucopyranoside, a compound isolated from Saussrurea lappa, is a moderate inhibitor of human protein tyrosine phosphatase 1B (hPTP1B) with an IC50 of 26.6 μM [1].
|
-
- HY-113320
-
|
5β-Androsterone
|
GABA Receptor
Endogenous Metabolite
|
Neurological Disease
|
|
Etiocholanolone (5β-Androsterone) is the excreted metabolite of testosterone and has anticonvulsant activity [1]. Etiocholanolone is a less potent neurosteroid positive allosteric modulator (PAM) of the GABAA receptor than its enantiomer form .
|
-
- HY-152388
-
|
|
Nucleoside Antimetabolite/Analog
|
Others
|
|
3’-beta-C-Methyluridine is a uridine analogue. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents [1].
|
-
- HY-133963
-
-
- HY-154864
-
-
- HY-N1459A
-
|
5-Ergosten-3β-ol
|
Others
|
Others
|
|
(S)-Campesterol (5-Ergosten-3β-ol) is a plant sterol [1].
|
-
- HY-W338150
-
-
- HY-W342830
-
-
- HY-W788728
-
-
- HY-N0230
-
|
2-Carboxyethylamine; 3-Aminopropanoic acid
|
Endogenous Metabolite
|
Metabolic Disease
|
|
β-Alanine is a non-essential amino acid that is shown to be metabolized into carnosine, which functions as an intracellular buffer.
|
-
- HY-N10860
-
|
|
Angiotensin Receptor
|
Others
|
|
5-O-beta-D-Glucopyranosylmyricanol is a diarylheptane compound isolated from Myrica esculenta that has a weak inhibitory effect on angiotensin-converting enzyme (ACE) [1].
|
-
- HY-P3780
-
|
|
Amyloid-β
|
Neurological Disease
|
|
Cys-Gly-Lys-Lys-Gly-Amyloid β-Protein (36-42) is the 36-42 fragment of Amyloid β-Protein. β-amyloid, a polypeptide made up of 36-43 amino acids, is the main component of amyloid plaques found in the brains of people with Alzheimer's disease. β-amyloid oligomers (Aβos) plays A key role in the progression of Alzheimer's disease (AD) by inducing neuronal damage and cognitive impairment [1].
|
-
- HY-W145783
-
|
β-Cyclodextrin perbenzoate
|
Biochemical Assay Reagents
|
Others
|
|
Heptakis(2,3,6-tri-O-benzoyl)-β-cyclodextrin is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W412723
-
|
β-D-Glucopyranuronic acid tetraacetate
|
Biochemical Assay Reagents
|
|
|
1,2,3, 4-tetra-o-acetyl-β-d-glucuronic acid (β-D-Glucopyranuronic acid tetraacetate) is a class of biochemical reagents used in the study of glycobiology. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It deals with carbohydrate chemistry, glycan formation and degradation enzymology, protein-glycan recognition, and the role of glycans in biological systems. The field is closely related to basic research, biomedicine and biotechnology [1].
|
-
- HY-N11983
-
|
|
Others
|
Others
|
|
(25R)-Ruscogenin-3-yl α-L-rhamnopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→4)]-β-D-glucopyranoside (compound 1) is a steroidal saponin , can be isolated from the roots of Ophiopogon japonicus [1].
|
-
![(25R)-Ruscogenin-3-yl α-L-rhamnopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→4)]-β-D-glucopyranoside](//file.medchemexpress.com/product_pic/hy-n11983.gif)
- HY-165104
-
|
GuCGp; Gulopyranosyl-(β1-1)-caldarchaetidylglycerol
|
Bacterial
|
Others
|
|
β-L-Gulopyranosyl-caldarchaetidyl-glycerol (GuCGp) is a compound that is studied in the polar lipid composition of thermoacidophilic bacteria. Its content varies under different culture conditions, which may be related to the adaptation of bacteria to the environment.
|
-
- HY-P2315
-
|
HβD-1
|
Antibiotic
Bacterial
|
Infection
|
|
Human β-defensin-1 (HβD-1) is a cysteine-rich cationic skin-antimicrobial peptide (SAP) produced by all epithelial surfaces, but also by circulatory cells and cells of the reproductive tract. Human β-defensin-1 has antimicrobial activities against a broad-sperm bacteria [1].
|
-
- HY-N7176
-
|
Kaempferol-3-glucuronide; Kaempferol-3-O-glucuronide
|
Interleukin Related
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-glucuronide) is a metabolite of kaempferol that can be taken orally and has anti-inflammatory properties. Kaempferol 3-O-β-D-glucuronide can activate AKT/GSK3β phosphorylation and improve glucose metabolism [1] .
|
-
- HY-141131
-
|
|
PROTAC Linkers
|
Cancer
|
|
Propargyl-PEG2-beta-D-glucose is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1].
|
-
- HY-N1824
-
|
1β-Hydroxy-lupeol
|
Others
|
Others
|
|
3-Epiglochidiol (1β-Hydroxy-lupeol) is a Alkaloids product that can be isolated from the barks of Pandanus amaryllifolius [1].
|
-
- HY-141132
-
|
|
PROTAC Linkers
|
Cancer
|
|
Propargyl-PEG4-beta-D-glucose is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1].
|
-
- HY-N12202
-
|
|
Others
|
Others
|
|
6′-O-β-D-Glucopyranosylphlorigidoside C (compound 1) is an iridoid glycoside that can be isolated from Lamiophlomis rotata [1].
|
-
- HY-U00250
-
-
- HY-N10647
-
|
|
Others
|
Inflammation/Immunology
|
|
Isoscutellarein 8-O-β-D-glucuronide is a flavonoid antioxidant, can be isolated from Theobroma grandiflorum seeds [1] .
|
-
- HY-N3590
-
|
|
Others
|
Others
|
|
cis-3,4-Dihydroxy-β-ionone is a Sesquiterpenoids product that can be isolated from the herbs of Gynura nepalensis. [1].
|
-
- HY-154769S
-
-
- HY-N9262
-
|
|
Others
|
Others
|
|
2α,7β,13α-Triacetoxy-5α-cinnamoyloxy-9β-hydroxy-2(3→20)abeotaxa-4(20),11-dien-10-one is a Diterpenoids product that can be isolated from the herbs of Taxus yunnanensis [1].
|
-
- HY-152394
-
|
|
Nucleoside Antimetabolite/Analog
|
Others
|
|
3’-beta-C-Methylcytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities [1].
|
-
- HY-N9774
-
|
|
Others
|
Others
|
|
(3β,20S)-Pregn-5-ene-3,17,20-triol is a natural product [1].
|
-
- HY-W701864
-
-
- HY-P990207
-
|
|
Integrin
|
Others
|
|
Anti-Mouse/Human Integrin β7 Antibody (FIB504) is a rat-derived IgG2a, κ type antibody inhibitor, targeting to mouse/human Integrin β7.
|
-
- HY-129953S
-
-
- HY-152477
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
3’-β-C-Ethynyladenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) [1]. 3’-β-C-Ethynyladenosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-N10439
-
|
|
Glycosidase
|
Inflammation/Immunology
|
|
3β-Acetoxy-hop-22(29)-ene (compound 1) is a potent anti-inflammatory agent. 3β-Acetoxy-hop-22(29)-ene shows high inhibitory activity of yeast α-glucosidase, with an IC50 of 5.74 μM. 3β-Acetoxy-hop-22(29)-ene inhibits MPO (myeloperoxidase) activity in a dose-dependent manner in mouse ear edema model induced by 12-O-tetradecanoylphorbol acetate (TPA), with an IC50 of 0.23 μmol/ear [1].
|
-
- HY-P2869
-
|
EC 3.2.1.23; GAL
|
Endogenous Metabolite
|
Others
|
|
β-Galactosidase (EC 3.2.1.23) is a glycoside hydrolase that hydrolyzes the β-glycosidic bonds formed between galactose and its organic moieties. In E.coli, the lacZ gene is the structural gene of β-galactosidase, which can be used as part of the induction system lac operon. β-Galactosidase can hydrolyze lactose to form glucose and galactose, and enter glycolysis; it can also catalyze the transgalactosylation of lactose into allolactose; allolactose can be cracked into monosaccharides [1].
|
-
- HY-W250163
-
|
β-DPN lithium; β-NAD lithium; β-Nicotinamide Adenine Dinucleotide lithium
|
Biochemical Assay Reagents
|
Metabolic Disease
|
|
NAD+ lithium (β-DPN lithium) is a lithium salt of nicotinamide adenine dinucleotide. NAD+ is a coenzyme in the REDOX reaction. NAD+ can directly or indirectly affect several key cellular functions, including metabolic pathways, DNA repair, chromatin remodeling, cell aging, and immune cell function [1].
|
-
- HY-N8573S
-
-
- HY-P1504
-
-
- HY-W054064
-
|
|
Fungal
|
Infection
|
|
Chloro-7-deazapurine-β-D-riboside is a nucleoside derivative and has antifungal activity [1].
|
-
- HY-N8054
-
-
- HY-A0058
-
|
Retinyl β-D-glucoside
|
Drug Metabolite
|
Metabolic Disease
|
|
Retinyl-β-D-glucoside is a naturally occurring and biologically active metabolites of vitamin A, which are found in fish and mammals.
|
-
- HY-N2775
-
|
|
Others
|
Others
|
|
8-Hydroxy-5-O-beta-D-glucosylpsoralen is a natural coumarin glucoside [1].
|
-
- HY-E70131
-
|
Endo-β-N-acetylglucosaminidase H
|
Others
|
Metabolic Disease
|
|
Endo H, Streptomyces picatus (Endo-β-N-acetylglucosaminidase H), isolated from Streptomyces plicatus, hydrolyzes the central glycosidic bond of the β1, 4-di-N-acetylchitobiose core in asparagine-linked oligosaccharides [1].
|
-
- HY-141464
-
|
Fmoc-Asn(Ac3AcNH-beta-Glc)-OH
|
Amino Acid Derivatives
|
Cancer
|
|
Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OH (Fmoc-Asn(Ac3AcNH-beta-Glc)-OH) can be used in the synthesis of silicon-fluoride acceptor (SiFA) derivatized octreotate derivatives. SiFA-octreotate analogues, as tumor imaging agents, are useful tool for the research of positron emission tomography (PET) [1].
|
-
- HY-W048545
-
|
β-D-Glucopyranuronic acid, methyl ester, 2,3,4-triacetate
|
Drug Intermediate
|
Infection
|
|
2,3,4-Tri-O-acetyl-β-D-glucuronide methyl ester (β-D-Glucopyranuronic acid, methyl ester, 2,3,4-triacetate) is a synthetic intermediate in the synthesis of prodrug forms of the antitumor antibiotic Daunomycin (HY-13062A).
|
-
- HY-128974S
-
|
Lauryl Maltoside-d25
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
|
Others
|
|
N-Dodecyl-β-D-maltoside-d25 (Lauryl Maltoside-d25) is deuterium labeled N-Dodecyl-β-D-maltoside (HY-128974). N-Dodecyl-β-D-maltoside is a non-ionic detergent. N-Dodecyl-β-D-maltoside has strong adsorption on alumina, titanium dioxide and hematite. N-Dodecyl-β-D-maltoside can promote the reactivation of various proteins. N-Dodecyl-β-D-maltoside can effectively stabilize photoactive reaction center complexes (RCs) and inhibit the degradation of Rhodopseudomonas spheroides R-26 reaction center in solution. N-Dodecyl-β-D-maltoside can be used for purification and stabilization of RNA polymerase and for detection of protein-lipid interactions [1] .
|
-
- HY-103397A
-
|
Antibiotic YS-02931K-β
|
Biochemical Assay Reagents
|
Infection
|
|
Dihydrokalafungin (Antibiotic YS-02931K-β) is a benzoisochromanequinone that used as a natural substrate in enzyme assays of the ActVB-ActVA system [1].
|
-
- HY-138290
-
-
- HY-N2601
-
|
|
Others
|
Inflammation/Immunology
|
|
Bayogenin 3-O-β-D-glucopyranoside, a triterpenoid saponin isolated from Polygala japonica, possesses anti-inflammatory activities [1].
|
-
- HY-N12005
-
|
|
Others
|
Others
|
|
6-Hydroxykaempferol 7-O-β-glucopyranoside (compound 5) is a flavonol isolated from wild marigold (Tagetes minuta) [1].
|
-
- HY-N9278
-
|
|
Others
|
Others
|
|
8beta-(2-Hydroxy-2-methyl-3-oxobutyryloxy)glucozaluzanin C is a Sesquiterpenoids product that can be isolated from the herbs of Crepis crocea. [1].
|
-
- HY-N13014
-
|
|
Others
|
Others
|
|
Indole-3-acetyl β-D-glucopyranose is a glucose esterified derivative of the plant hormone indole-3-acetic acid (IAA). Indole-3-acetyl β-D-glucopyranose is involved in regulating plant growth and can be used to study the metabolism and regulatory mechanisms of plant hormones [1].
|
-
- HY-P1873
-
|
|
Ser/Thr Protease
|
Endocrinology
|
|
Phosphorylase Kinase β-Subunit Fragment (420-436) is the β-Subunit fragment (peptide 430-436) of phosphorylase kinase. Phosphorylase kinase is a serine/threonine-specific protein kinase which activates glycogen phosphorylase to release glucose-1-phosphate from glycogen [1].
|
-
- HY-113259AS
-
-
- HY-N9397
-
|
|
Others
|
Metabolic Disease
|
|
Quercetin 3-O-(6''-O-malonyl)-β-D-glucoside is a flavonol glycoside. Quercetin 3-O-(6''-O-malonyl)-β-D-glucoside possesses antioxidant activity [1] .
|
-
- HY-129953S1
-
-
- HY-P2291A
-
|
|
Bacterial
|
Inflammation/Immunology
|
|
Beta-defensin 103 isoform X1, pig TFA is an antimicrobial peptide found in different living organisms, involved in the first line of defense in their innate immune response against pathogens [1].
|
-
- HY-W661016
-
|
1-Azido-1-deoxy-beta-D-galactopyranoside, 97%
|
Biochemical Assay Reagents
|
Others
|
|
1-Azido-1-deoxy-β-D-galactopyranoside, 97% is extensively used in research on glycosylation processes and enzyme mechanisms.
|
-
- HY-N15225
-
|
|
Others
|
Others
|
|
12β-Hydroxyganoderenic acid B (Compound 15) is the triterpenoid compound that can be isolated from Ganoderma lucidum. Some triterpenoids isolated from Ganoderma species are reported to exhibits antitumor, antimicrobial, antiviral and anti-aging activities [1].
|
-
- HY-B0406
-
|
Carbamyl-β-methylcholine
|
mAChR
|
Neurological Disease
Cancer
|
|
Bethanechol (Carbamyl-β-methylcholine), a parasympathomimetic agent, is a mAChR agonist that exerts its effects via directly stimulating the mAChR (M1, M2, M3, M4, and M5) of the parasympathetic nervous system [1].
|
-
- HY-B0406A
-
|
Carbamyl-β-methylcholine chloride
|
mAChR
|
Neurological Disease
Cancer
|
|
Bethanechol chloride (Carbamyl-β-methylcholine chloride), a parasympathomimetic agent, is a mAChR agonist that exerts its effects via directly stimulating the mAChR (M1, M2, M3, M4, and M5) of the parasympathetic nervous system [1].
|
-
- HY-P1868
-
|
DGEA peptide
|
Integrin
|
Infection
|
|
α2β1 Integrin Ligand Peptide interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellular signals into cells. It is a potential antagonist of collagen receptors [1].
|
-
- HY-154655
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
6-Methyl-9-(2-β-C-methyl-2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)purine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc [1].
|
-
- HY-W415809
-
-
- HY-P2656
-
|
hBD-4
|
Bacterial
|
Infection
|
|
β-Defensin-4 human is an inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity [1].
|
-
- HY-N1628
-
|
1-Hydroxybaccatin I
|
Others
|
Others
|
|
1β-Hydroxybaccatin I (1-Hydroxybaccatin I) can be extracted from Taxus wallichiana [1].
|
-
- HY-164032
-
|
7α,11β-Dimethyl-17β-hydroxyestr-4-en-3-one 17-undecanoate
|
GnRH Receptor
|
Endocrinology
|
|
Dimethandrolone undecanoate (7α,11β-Dimethyl-17β-hydroxyestr-4-en-3-one 17-undecanoate) exhibits withrogens and progesterone activity. Dimethandrolone undecanoate inhibits production of gonadotropins, suppresses testosterone production, and thus inhibits sperm production. Dimethandrolone undecanoate is potent for development of male hormone contraceptives [1].
|
-
- HY-137779
-
|
|
Biochemical Assay Reagents
|
Others
|
|
5-Bromo-4-chloro-3-indolyl β-D-glucopyranoside, a chromogenic substrate for the detection of β-galactosidase activity. It is commonly used in molecular biology techniques such as gene expression analysis and reporter gene analysis. When β-galactosidase cleaves X-Gluc, a blue precipitate is produced, which can be observed by microscopy or other detection methods. X-Gluc has high sensitivity and specificity for the detection of β-galactosidase activity, making it a widely used tool in molecular biology research.
|
-
- HY-W416111
-
-
- HY-15921A
-
-
- HY-W328494
-
-
- HY-N0892
-
-
- HY-P2511
-
-
- HY-W145491
-
|
|
Biochemical Assay Reagents
|
Others
|
|
4-O-β-Galactopyranosyl-D-mannopyranose is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-N0713
-
|
|
Others
|
Others
|
|
Diosmetin-7-O-β-D-glucopyranoside is a natural product isolated from the flowers of Chrysanthemum morifolium, with antioxidant activity [1] .
|
-
- HY-N8205
-
-
- HY-169354
-
![[Ala28]-β Amyloid(25-35)](http://file.medchemexpress.com/product_pic/hy-p5968.gif)
![Periplogenin 3-[O-β-glucopyranosyl-(1→4)-β-sarmentopyranoside]](http://file.medchemexpress.com/product_pic/hy-n5053.gif)
![3-O-β-D-Glucopyranosyl(1→2)-[a-Lrhamnopyranosyl(1→3)]-β-D-glucopyranosyl 28-O-β-D-glucuronopyranoside](http://file.medchemexpress.com/product_pic/hy-n9521.gif)
![Luteolin 7-O-[β-D-apiofuranosyl-(1→6)]-β-D-glucopyranoside](http://file.medchemexpress.com/product_pic/hy-n13142.gif)
![Gal[246Bn]β(1-4)Glc[236Bn]-β-MP](http://file.medchemexpress.com/product_pic/hy-w145620.gif)
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