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Results for "

Adenylate Cyclase

" in MCE Product Catalog:

By Targets:	Adenylate Cyclase (19) Autophagy (2) Bacterial (1) Calcium Channel (1) Calmodulin (1) CGRP Receptor (1) Dopamine Receptor (2) Dopamine Transporter (2) Endogenous Metabolite (2) FXR (2) Melanocortin Receptor (1) Parasite (1) Somatostatin Receptor (2)
By Research Areas:	Cancer (3) Cardiovascular Disease (5) Endocrinology (4) Infection (1) Inflammation/Immunology (6) Metabolic Disease (4) Neurological Disease (12)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Targets Recommended: Adenylate Cyclase Guanylate Cyclase

Cat. No.	Product Name	Target	Research Areas

HY-137167

Guanylyl imidodiphosphate lithium Gpp(NH)p lithium	Adenylate Cyclase	Endocrinology
Guanylyl imidodiphosphate (Gpp(NH)p) lithium, a non-hydrolyzable GTP analogue, increases **adenylate cyclase** activity.

HY-116530

9-Cyclopentyladenine monomethanesulfonate 9-CP-Ade mesylate	Adenylate Cyclase	Neurological Disease Others
9-Cyclopentyladenine monomethylsulfonate (9-CP-Ade mesylate) is a stable non-competitive **adenylate cyclase** inhibitor with cell permeable properties.

HY-100767

Guanylyl Imidodiphosphate trisodium Guanosine 5'-[β,γ-imido]triphosphate trisodium	Adenylate Cyclase	Endocrinology
Guanylyl Imidodiphosphate (Guanosine 5'-[β,γ-imido]triphosphate) trisodium is a non-hydrolysable GTP analogue, an activator of ADP-ribosylation factor (ARF) and a potent stimulator of **adenylate cyclase**. Imidodiphosphate trisodium can be used in protein synthesis studies.

HY-N10772

Albanin A	Calcium Channel Calmodulin Adenylate Cyclase	Inflammation/Immunology Neurological Disease
Albanin A, a flavonoid, suppresses glutamate release by decreasing *Ca²⁺/calmodulin/adenylate* Cyclase 1 (AC1)** activation in synaptosomes and exerts neuroprotective effect in vivo. Albanin A has anti-inflflammatory activity.

HY-101862

CB-7921220
Adenylate Cyclase Neurological Disease Cardiovascular Disease

CB-7921220 is an adenylate cyclase inhibitor.
HY-100396

SQ22536
Adenylate Cyclase Metabolic Disease

SQ22536 is an effective adenylate cyclase (AC) inhibitor.

CB-7921220	Adenylate Cyclase	Neurological Disease Cardiovascular Disease
CB-7921220 is an **adenylate cyclase** inhibitor.

SQ22536	Adenylate Cyclase	Metabolic Disease
SQ22536 is an effective **adenylate cyclase** (AC) inhibitor.

HY-P0004

Lysipressin Lysine vasopressin; [Lys8]-Vasopressin	Adenylate Cyclase	Others
Lysipressin (Lysine vasopressin) is antidiuretic hormone that have been found in pigs and some marsupial families. Lysipressin induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase.

HY-P0004A

Lysipressin acetate Lysine vasopressin acetate; [Lys8]-Vasopressin acetate	Adenylate Cyclase	Others
Lysipressin (Lysine vasopressin) acetate is antidiuretic hormone that have been found in pigs and some marsupial families. Lysipressin acetate induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase.

HY-P1495

Small Cardioactive Peptide B (SCPB)	Adenylate Cyclase	Neurological Disease Cardiovascular Disease
Small Cardioactive Peptide B (SCP_B), a neurally active peptide, stimulates **adenylate cyclase activity in particulate fractions of both heart and gill tissues with EC₅₀**s of 0.1 and 1.0 μM, respectively.

HY-B1124A

Fipexide hydrochloride	Adenylate Cyclase Dopamine Transporter	Neurological Disease
Fipexide hydrochloride, a parachloro-phenossiacetic acid derivative, is a nootropic agent. Fipexide hydrochloride reduces striatal **adenylate cyclase activity. Fipexide hydrochloride has positive effect on cognitive performance by dopaminergic neurotransmission**. Fipexide hydrochloride is used for senile dementia research.

HY-B1124

Fipexide	Adenylate Cyclase Dopamine Transporter	Neurological Disease
Fipexide, a parachloro-phenossiacetic acid derivative, is a nootropic agent. Fipexide reduces striatal **adenylate cyclase activity. Fipexide has positive effect on cognitive performance by dopaminergic** neurotransmission. Fipexide is used for senile dementia research.

HY-15371

Forskolin Coleonol; Colforsin; HL 362	Adenylate Cyclase FXR Autophagy	Cancer Endocrinology Metabolic Disease Inflammation/Immunology
Forskolin (Coleonol) is a potent **adenylate cyclase activator with an IC₅₀ of 41 nM and an EC₅₀** of 0.5 μM for type I adenylyl cyclase. Forskolin is also an inducer of intracellular cAMP formation. Forskolin induces differentiation of various cell types and activates pregnane X receptor (PXR) and FXR. Forskolin exerts a inotropic effect on the heart, and has platelet antiaggregatory and antihypertensive actions. Forskolin also induces autophagy.

HY-15371G

Forskolin Coleonol; Colforsin; HL 362	Adenylate Cyclase FXR Autophagy	Cancer Endocrinology Metabolic Disease Inflammation/Immunology
Forskolin (Coleonol) (GMP) is Forskolin (HY-15371) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Forskolin is a potent **adenylate cyclase activator and inducer of intracellular cAMP** formation.

HY-147557

PAC1R antagonist 1	Others	Neurological Disease
PAC1R antagonist 1 (compound 3d) is a potent and orally active antagonist of PAC1 receptor. PAC1R antagonist 1 can inhibit pituitary adenylate cyclase-activating polypeptide (PACAP)- and nerve injury-induced allodynia.

HY-W010791

Adenosine 5'-diphosphate sodium salt	Endogenous Metabolite	Others
Adenosine 5'-diphosphate (ADP) sodium salt is a nucleoside diphosphate, which is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate sodium salt induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P_2T-purinoceptors.

HY-W010918

Adenosine 5'-diphosphate Adenosine diphosphate; ADP	Endogenous Metabolite	Others
Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P_2T-purinoceptors.

HY-P3689

[Tyr22] Calcitonin Gene Related Peptide, (22-37), rat	CGRP Receptor Adenylate Cyclase	Others
[Tyr22] Calcitonin Gene Related Peptide, (22-37), rat is a fragments 22-37 of rat calcitonin gene related peptide (CGRP), targeting CGRP receptor and **adenylate cyclase**. Calcitonin is mainly produced by thyroid C cells while CGRP is secreted and stored in the nervous system.

HY-17592

Bithionol	Parasite Bacterial	Cancer Infection
Bithionol is an antibacterial, anthelmintic, and algaecide agent. Bithionol is also a potent inhibitor of soluble adenylyl cyclase through binding to the allosteric activator site (IC₅₀: 4 μM).

HY-129421

PA-9	Others	Inflammation/Immunology Neurological Disease
PA-9 is a pituitary adenylate cyclase-activating polypeptide (PACAP) type I (PAC1) receptor antagonist. PA-9 dose dependently inhibits PACAP-induced cAMP elevation with an IC₅₀ of 5.6 nM. PA-9 can be used for the research of neuropathic and/or inflammatory pain.

HY-P3645

(Nle4)-α-MSH	Melanocortin Receptor	Others
(Nle4)-α-MSH is a synthetic analogue of α-MSH (HY-P0252), a melanocyte-stimulating hormone. (Nle4)-α-MSH reversibly darkens frog skins and also exhibits prolonged activity after heat-alkali treatment.

HY-103193

NKH477 Colforsin dapropate hydrochloride	Adenylate Cyclase	Cardiovascular Disease
NKH477 (Colforsin dapropate hydrochloride) directly activates the catalytic unit of **adenylate cyclase** and increases intracellular cAMP. NKH477 is a forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 exerts an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts.

HY-P1446

Cholera toxin Choleragen	Adenylate Cyclase	Inflammation/Immunology
Cholera toxin (Choleragen), an AB(5)-subunit toxin, enters host cells by binding the ganglioside GM1 at the plasma membrane (PM) and travels retrograde through the trans-Golgi Network into the endoplasmic reticulum (ER). Choleragen activates **adenylate cyclase** by catalyzing ADP-ribosylation of Gs alpha, the stimulatory guanine nucleotide-binding protein.

HY-146356

Adenylyl cyclase type 2 agonist-1	Adenylate Cyclase	Inflammation/Immunology
Adenylyl cyclase type 2 agonist-1 (Compound 73) is a potent agonist of adenylyl cyclase type 2 (AC2) with the EC₅₀ of 90 nM. Adenylyl cyclase type 2 agonist-1 inhibits expression of Interleukin-6, making it a potential lead compound against respiratory diseases.

HY-10435

SKF-82958 (±)-SKF-82958; Chloro-APB	Dopamine Receptor	Neurological Disease
SKF-82958 ((±)-SKF 82958) is a dopamine D1 receptor full agonist (K_0.5=4 nM), displays selective for D1 over D2 receptors (K_0.5=73 nM). SKF-82958 induces dopamine D1 receptor-dependent adenylate cyclase activity in rat striatal membranes (EC₅₀=491 nM).

HY-10435A

SKF-82958 hydrobromide (±)-SKF-82958 hydrobromide; Chloro-APB hydrobromide	Dopamine Receptor	Neurological Disease
SKF-82958 ((±)-SKF 82958) hydrobromide is a dopamine D1 receptor full agonist (K_0.5=4 nM), displays selective for D1 over D2 receptors (K_0.5=73 nM). SKF-82958 hydrobromide induces dopamine D1 receptor-dependent adenylate cyclase activity in rat striatal membranes (EC₅₀=491 nM).

HY-P2090

Angiopeptin	Somatostatin Receptor Adenylate Cyclase	Cardiovascular Disease
Angiopeptin, a cyclic octapeptide analogue of somatostatin, is a weak sst₂/sst₅ receptor partial agonist with IC₅₀ values of 0.26 nM and 6.92 nM, respectively. Angiopeptin is a potent inhibitor of growth hormone release and insulin-like growth factor-1 (IGF-1) production. Angiopeptin inhibits **adenylate cyclase** or stimulates extracellular acidification. Angiopeptin has the potential for coronary atherosclerosis research.

HY-P2090A

Angiopeptin TFA	Somatostatin Receptor Adenylate Cyclase	Cardiovascular Disease
Angiopeptin TFA, a cyclic octapeptide analogue of somatostatin, is a weak sst₂/sst₅ receptor partial agonist with IC₅₀ values of 0.26 nM and 6.92 nM, respectively. Angiopeptin TFA is a potent inhibitor of growth hormone release and insulin-like growth factor-1 (IGF-1) production. Angiopeptin TFA inhibits **adenylate cyclase** or stimulates extracellular acidification. Angiopeptin TFA has the potential for coronary atherosclerosis research.

Cat. No.	Product Name	Type

HY-100767

Guanylyl Imidodiphosphate trisodium Guanosine 5'-[β,γ-imido]triphosphate trisodium	Biochemical Assay Reagents
Guanylyl Imidodiphosphate (Guanosine 5'-[β,γ-imido]triphosphate) trisodium is a non-hydrolysable GTP analogue, an activator of ADP-ribosylation factor (ARF) and a potent stimulator of **adenylate cyclase**. Imidodiphosphate trisodium can be used in protein synthesis studies.

Cat. No.	Product Name	Target	Research Area

HY-P3617

Glucagon (22-29)	Peptides	Metabolic Disease
Glucagon (22-29) is partial agonist of Glucagon (19–29). Glucagon specifically inhibits the Ca²⁺ pump in liver plasma membranes independently of adenylate cyclase activation.

HY-P0004

Lysipressin Lysine vasopressin; [Lys8]-Vasopressin	Adenylate Cyclase	Others
Lysipressin (Lysine vasopressin) is antidiuretic hormone that have been found in pigs and some marsupial families. Lysipressin induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase.

HY-P0004A

Lysipressin acetate Lysine vasopressin acetate; [Lys8]-Vasopressin acetate	Adenylate Cyclase	Others
Lysipressin (Lysine vasopressin) acetate is antidiuretic hormone that have been found in pigs and some marsupial families. Lysipressin acetate induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase.

HY-P1495

Small Cardioactive Peptide B (SCPB)	Adenylate Cyclase	Neurological Disease Cardiovascular Disease
Small Cardioactive Peptide B (SCP_B), a neurally active peptide, stimulates **adenylate cyclase activity in particulate fractions of both heart and gill tissues with EC₅₀**s of 0.1 and 1.0 μM, respectively.

HY-P0221

PACAP (1-38), human, ovine, rat Pituitary Adenylate Cyclase Activating Polypeptide 38	Peptides	Neurological Disease
PACAP (1-38), human, ovine, rat is a neuropeptide with 38 amino acid residues. PACAP (1-38) binds to PACAP type I receptor, PACAP type II receptor VIP₁, and PACAP type II receptor VIP₂ with IC₅₀s of 4 nM, 2 nM, and 1 nM, respectively.

HY-P0221A

PACAP (1-38), human, ovine, rat TFA Pituitary Adenylate Cyclase Activating Polypeptide 38 TFA	Peptides	Neurological Disease
PACAP (1-38), human, ovine, rat TFA is a neuropeptide with 38 amino acid residues. PACAP (1-38) binds to PACAP type I receptor, PACAP type II receptor VIP₁, and PACAP type II receptor VIP₂ with IC₅₀s of 4 nM, 2 nM, and 1 nM, respectively.

HY-P3689

[Tyr22] Calcitonin Gene Related Peptide, (22-37), rat	CGRP Receptor Adenylate Cyclase	Others
[Tyr22] Calcitonin Gene Related Peptide, (22-37), rat is a fragments 22-37 of rat calcitonin gene related peptide (CGRP), targeting CGRP receptor and **adenylate cyclase**. Calcitonin is mainly produced by thyroid C cells while CGRP is secreted and stored in the nervous system.

HY-P3645

(Nle4)-α-MSH	Melanocortin Receptor	Others
(Nle4)-α-MSH is a synthetic analogue of α-MSH (HY-P0252), a melanocyte-stimulating hormone. (Nle4)-α-MSH reversibly darkens frog skins and also exhibits prolonged activity after heat-alkali treatment.

HY-P2090

Angiopeptin	Somatostatin Receptor Adenylate Cyclase	Cardiovascular Disease
Angiopeptin, a cyclic octapeptide analogue of somatostatin, is a weak sst₂/sst₅ receptor partial agonist with IC₅₀ values of 0.26 nM and 6.92 nM, respectively. Angiopeptin is a potent inhibitor of growth hormone release and insulin-like growth factor-1 (IGF-1) production. Angiopeptin inhibits **adenylate cyclase** or stimulates extracellular acidification. Angiopeptin has the potential for coronary atherosclerosis research.

HY-P2090A

Angiopeptin TFA	Somatostatin Receptor Adenylate Cyclase	Cardiovascular Disease
Angiopeptin TFA, a cyclic octapeptide analogue of somatostatin, is a weak sst₂/sst₅ receptor partial agonist with IC₅₀ values of 0.26 nM and 6.92 nM, respectively. Angiopeptin TFA is a potent inhibitor of growth hormone release and insulin-like growth factor-1 (IGF-1) production. Angiopeptin TFA inhibits **adenylate cyclase** or stimulates extracellular acidification. Angiopeptin TFA has the potential for coronary atherosclerosis research.

Cat. No.	Product Name	Target	Category

HY-N10772

Albanin A	Calcium Channel Calmodulin Adenylate Cyclase	Structural Classification Other Flavonoids Flavonoids Plants Source classification Moraceae Morus nigra Linn.
Albanin A, a flavonoid, suppresses glutamate release by decreasing *Ca²⁺/calmodulin/adenylate* Cyclase 1 (AC1)** activation in synaptosomes and exerts neuroprotective effect in vivo. Albanin A has anti-inflflammatory activity.

HY-P0004

Lysipressin Lysine vasopressin; [Lys8]-Vasopressin	Adenylate Cyclase	Monophenols Phenols Structural Classification Animals Source classification Other Diseases Disease Research Fields Classification of Application Fields
Lysipressin (Lysine vasopressin) is antidiuretic hormone that have been found in pigs and some marsupial families. Lysipressin induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase.

HY-15371

Forskolin Coleonol; Colforsin; HL 362	Adenylate Cyclase FXR Autophagy	Terpenoids Structural Classification Diterpenoids Gochnatia polymorpha (Less) Cabr. Labiatae Plants Source classification Inflammation/Immunology Metabolic Disease Disease Research Fields Classification of Application Fields Endocrinology
Forskolin (Coleonol) is a potent **adenylate cyclase activator with an IC₅₀ of 41 nM and an EC₅₀** of 0.5 μM for type I adenylyl cyclase. Forskolin is also an inducer of intracellular cAMP formation. Forskolin induces differentiation of various cell types and activates pregnane X receptor (PXR) and FXR. Forskolin exerts a inotropic effect on the heart, and has platelet antiaggregatory and antihypertensive actions. Forskolin also induces autophagy.

HY-W010791

Adenosine 5'-diphosphate sodium salt	Endogenous Metabolite	Ketones, Aldehydes, Acids Structural Classification Endogenous metabolite Source classification Other Diseases Disease Research Fields Classification of Application Fields
Adenosine 5'-diphosphate (ADP) sodium salt is a nucleoside diphosphate, which is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate sodium salt induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P_2T-purinoceptors.

HY-W010918

Adenosine 5'-diphosphate Adenosine diphosphate; ADP	Endogenous Metabolite	Ketones, Aldehydes, Acids Classification of Application Fields Disease Research Fields Other Diseases Source classification Endogenous metabolite Disease markers Nervous System Disorder Cardiovascular System Disorder
Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P_2T-purinoceptors.

Cat. No.	Product Name	Species	Source

HY-P77120

ADCYAP1R1 Protein, Human (HEK293, Fc)
Pituitary Adenylate Cyclase-activating polypeptide type I receptor; PACAP-R1; ADCYAP1R1
Human HEK293

Adenylate Cyclase

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

NaturalProducts

Recombinant Proteins

Natural
Products