Search Result

Targets Recommended:	Adenylate Cyclase Guanylate Cyclase GSK-3 PI3K FLT3 Oct3/4 Arp2/3 Complex Na+/HCO3- Cotransporter MAP3K Ligand for E3 Ligase Indoleamine 2,3-Dioxygenase (IDO) E3 Ligase Ligand-Linker Conjugate Progesterone Receptor E1/E2/E3 Enzyme PIKfyve TAM Receptor Dopamine Transporter ATM/ATR

Results for "Adenylyl cyclase 3 Inhibitors" in MCE Product Catalog:

By Targets:	Adenylate Cyclase (11) Guanylate Cyclase (25) ADC Cytotoxin (1) Adrenergic Receptor (1) Amyloid-β (5) Antibiotic (2) Apoptosis (3) Autophagy (3) Bacterial (3) Bcr-Abl (1) Calcium Channel (1) CaMK (1) Cannabinoid Receptor (1) Casein Kinase (1) DYRK (2) Endogenous Metabolite (5) Ephrin Receptor (1) Estrogen Receptor/ERR (1) Factor Xa (1) Fungal (1) FXR (1) GLUT (1) HIV (1) IKK (1) Microtubule/Tubulin (1) Mitophagy (1) MMP (1) Monoamine Oxidase (3) NO Synthase (2) P2X Receptor (1) p38 MAPK (1) Parasite (2) Phosphatase (1) PKA (1) PKC (1) Potassium Channel (1) Reverse Transcriptase (1) SARS-CoV (1) Sirtuin (1) Sodium Channel (1) Thrombin (1) TRP Channel (1)
By Research Areas:	Cancer (20) Cardiovascular Disease (22) Endocrinology (3) Infection (7) Inflammation/Immunology (10) Metabolic Disease (10) Neurological Disease (15)

By Targets:

Adenylate Cyclase (11)

Guanylate Cyclase (25)

ADC Cytotoxin (1)

Adrenergic Receptor (1)

Amyloid-β (5)

Antibiotic (2)

Apoptosis (3)

Autophagy (3)

Bacterial (3)

Bcr-Abl (1)

Calcium Channel (1)

CaMK (1)

Cannabinoid Receptor (1)

Casein Kinase (1)

DYRK (2)

Endogenous Metabolite (5)

Ephrin Receptor (1)

Estrogen Receptor/ERR (1)

Factor Xa (1)

Fungal (1)

FXR (1)

GLUT (1)

HIV (1)

IKK (1)

Microtubule/Tubulin (1)

Mitophagy (1)

MMP (1)

Monoamine Oxidase (3)

NO Synthase (2)

P2X Receptor (1)

p38 MAPK (1)

Parasite (2)

Phosphatase (1)

PKA (1)

PKC (1)

Potassium Channel (1)

Reverse Transcriptase (1)

SARS-CoV (1)

Sirtuin (1)

Sodium Channel (1)

Thrombin (1)

TRP Channel (1)

By Research Areas:

Cancer (20)

Cardiovascular Disease (22)

Endocrinology (3)

Infection (7)

Inflammation/Immunology (10)

Metabolic Disease (10)

Neurological Disease (15)

Inhibitors & Agonists

Dye Reagents

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas

HY-135878

2',5'-Dideoxyadenosine	Adenylate Cyclase Adrenergic Receptor	Metabolic Disease
2',5'-Dideoxyadenosine is a potent and non-competitive **adenylyl cyclase inhibitor via binding the P-site with an IC₅₀ of 3 µM . 2',5'-Dideoxyadenosine is a nucleoside analog and exerts a potent antiadrenergic** action in heart.

HY-103195

NKY80	Adenylate Cyclase	Metabolic Disease
NKY80 is a potent, selective and non-competitive adenylyl cyclase (AC) type V isoform inhibitor with IC₅₀s of 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively. NKY80 is a non-nucleoside quinazolinone and regulates the AC catalytic activity in heart and lung tissues.

HY-112461A

NF449 octasodium	P2X Receptor	Cardiovascular Disease
NF449 octasodium is a highly potent P2X₁ receptor antagonist, with IC₅₀s of 0.28, 0.69, and 120 nM for rP2X₁, rP2X₁₊₅, P2X₂₊₃, respectively. NF449 octasodium is a G_sα-selective G Protein antagonist. NF449 octasodium suppresses the rate of GTP[γS] binding to G_sα-s, inhibits the stimulation of adenylyl cyclase activity, and blocks the coupling of β-adrenergic receptors to G_s.

HY-100524

LRE1
Adenylate Cyclase Cancer

LRE1 is a specific and allosteric inhibitor of soluble adenylyl cyclase.

LRE1	Adenylate Cyclase	Cancer
LRE1 is a specific and allosteric inhibitor of soluble **adenylyl cyclase**.

HY-128933

AMP-PNP tetralithium Adenylyl-imidodiphosphate tetralithium	Potassium Channel	Metabolic Disease
AMP-PNP tetralithium (Adenylyl-imidodiphosphate tetralithium) is a non-hydrolysable analogue of ATP and inhibits K_ATP channels.

HY-112270

Glutaminyl Cyclase Inhibitor 2
Amyloid-β Neurological Disease

Glutaminyl Cyclase Inhibitor 2 is a glutaminyl cyclase inhibitor with an IC₅₀ of 1.23 μM.
HY-112269

Glutaminyl Cyclase Inhibitor 1
Amyloid-β Neurological Disease

Glutaminyl Cyclase Inhibitor 1 is a glutaminyl cyclase inhibitor with an IC₅₀ of 0.5 μM.

*Glutaminyl Cyclase* Inhibitor 2**	Amyloid-β	Neurological Disease
Glutaminyl Cyclase Inhibitor 2 is a glutaminyl cyclase inhibitor with an IC₅₀ of 1.23 μM.

*Glutaminyl Cyclase* Inhibitor 1**	Amyloid-β	Neurological Disease
Glutaminyl Cyclase Inhibitor 1 is a glutaminyl cyclase inhibitor with an IC₅₀ of 0.5 μM.

HY-126331

*Glutaminyl Cyclase* Inhibitor 4**	Amyloid-β	Neurological Disease
Glutaminyl Cyclase Inhibitor 4 (compound 90) is a potent, selective *glutaminyl cyclase* (QC) inhibitor with an IC₅₀** of 6.1 nM. Glutaminyl Cyclase Inhibitor 4 is a potent anti-Alzheimer’s agent.

HY-P0252

α-Melanocyte-Stimulating Hormone (MSH), amide	Adenylate Cyclase	Metabolic Disease
α-Melanocyte-Stimulating Hormone (MSH), amide stimulates melanocortin 1 receptor that results in the activation of **adenylyl cyclase**.

HY-101282

*Glutaminyl Cyclase* Inhibitor 3**	Amyloid-β	Neurological Disease
Glutaminyl Cyclase Inhibitor 3 (compound 212 ), a designed anti-Alzheimer’s compound, is a potent human *Glutaminyl Cyclase* (GC) inhibitor, with an IC₅₀** of 4.5 nM. Glutaminyl Cyclase-IN-1 (compound 212) significantly reduced the brain concentrations of pyroform Aβ and total Aβ and restored cognitive functions.

HY-101279

ST034307
Adenylate Cyclase Neurological Disease

ST034307 is a potent and selective adenylyl cyclase 1 (AC1) inhibitor, with IC₅₀ of 2.3 μM.

ST034307	Adenylate Cyclase	Neurological Disease
ST034307 is a potent and selective adenylyl cyclase 1 (AC1) inhibitor, with IC₅₀ of 2.3 μM.

HY-15371

Forskolin Coleonol; Colforsin	Adenylate Cyclase FXR Autophagy	Cancer Endocrinology Metabolic Disease Inflammation/Immunology
Forskolin (Coleonol) is a potent adenylate cyclase activator with an IC₅₀ of 41 nM and an EC₅₀ of 0.5 μM for type I adenylyl cyclase. Forskolin is also an inducer of intracellular cAMP formation. Forskolin induces differentiation of various cell types and activates pregnane X receptor (PXR) and *FXR. Forskolin exerts a inotropic effect on the heart, and has platelet antiaggregatory and antihypertensive actions. Forskolin also induces autophagy*.

HY-103194

KH7	Others	Others
KH7 is a *soluble adenylyl* cyclase (sAC)-specific inhibitor, with IC₅₀s of 3-10 μM toward both recombinant purified human sAC_t protein and heterologously expressed sACt in cellular assays. KH7 is also a cAMP** inhibitor.

HY-U00439

Protein kinase inhibitors 1
DYRK Cancer

Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC₅₀ of 74 nM and K_d of 9.5 nM.

*Protein kinase inhibitors* 1**	DYRK	Cancer
Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC₅₀ of 74 nM and K_d of 9.5 nM.

HY-P1852

TIP 39, Tuberoinfundibular Neuropeptide	Adenylate Cyclase	Neurological Disease
TIP 39, Tuberoinfundibular Neuropeptide is a neuropeptide and parathyroid hormone 2 receptor (PTH2R) agonist. TIP 39 is highly conserved among species. TIP39 from all species activates adenylyl cyclase and elevates intracellular calcium levels through parathyroid hormone 2 receptor (PTH2R).

HY-116175

BIBB 515	Others	Metabolic Disease
BIBB 515 is a potent, selective and orally active *2,3-oxidosqualene cyclase* (OSC) inhibitor with ED₅₀** values of 0.2-0.5 mg/kg and 0.36-33.3 mg/kg in rats and mice (1-5 hours), respectively. BIBB 515 exerts lipid-lowering effect mainly by inhibiting the production of low-density lipoprotein (LDL).

HY-16561

Resveratrol trans-Resveratrol; SRT501	IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic	Cancer Infection Inflammation/Immunology
Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, **Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1** activator. Resveratrol is a potent pregnane X receptor (PXR) inhibitor.

HY-101862

CB-7921220
Adenylate Cyclase Neurological Disease Cardiovascular Disease

CB-7921220 is an adenylate cyclase inhibitor.
HY-100396

SQ22536
Adenylate Cyclase Metabolic Disease

SQ22536 is an effective adenylate cyclase (AC) inhibitor.
HY-12376

BAY 41-2272
Guanylate Cyclase Inflammation/Immunology

BAY 41-2272 is a soluble guanylate cyclases (sGC) activator.

CB-7921220	Adenylate Cyclase	Neurological Disease Cardiovascular Disease
CB-7921220 is an adenylate cyclase inhibitor.

SQ22536	Adenylate Cyclase	Metabolic Disease
SQ22536 is an effective adenylate cyclase (AC) inhibitor.

BAY 41-2272	Guanylate Cyclase	Inflammation/Immunology
BAY 41-2272 is a soluble guanylate cyclases (sGC) activator.

HY-101995

Ridaifen-B RID-B	Estrogen Receptor/ERR Cannabinoid Receptor	Cancer Metabolic Disease Inflammation/Immunology
Ridaifen-B (RID-B) is a potent antagonist of estrogen receptor α (ERα) with IC₅₀ of 52.4 nM, a tamoxifen derivative. Ridaifen-B is a high affinity, selective, inverse agonist at CB₂ receptor (K_i=43.7 nM) over 17 folds CB₁ receptor (K_i=732 nM). Ridaifen-B modulates G-protein (IC₅₀=300 nM) and adenylyl cyclase activity with potency values predicted by CB₂ affinity (IC₅₀=134 nM). Ridaifen-B has anti-inflammatory, anti-cancer, and anti-osteoclastogenic effects.

HY-100295

(4-Acetamidocyclohexyl) nitrate
BM121307
Guanylate Cyclase Cardiovascular Disease

(4-Acetamidocyclohexyl) nitrate (BM121307) is a guanylate cyclase activator.
HY-18630A

Ro 48-8071 fumarate
Others Cancer

Ro 48-8071 fumarate is an inhibitor of OSC (Oxidosqualene cyclase) with IC₅₀ of appr 6.5 nM.
HY-16774

Vericiguat
BAY1021189
Guanylate Cyclase Cardiovascular Disease

Vericiguat (BAY1021189) is a potent, orally available and soluble guanylate cyclase stimulator.
HY-14181

Cinaciguat
BAY 58-2667
Guanylate Cyclase Cardiovascular Disease

Cinaciguat is an activator of guanylate cyclase (sGC), and used for acute decompensated heart failure.
HY-18630

Ro 48-8071
Others Cancer

Ro 48-8071 is an inhibitor of OSC (Oxidosqualene cyclase) with IC₅₀ of appr 6.5 nM.

(4-Acetamidocyclohexyl) nitrate BM121307	Guanylate Cyclase	Cardiovascular Disease
(4-Acetamidocyclohexyl) nitrate (BM121307) is a guanylate cyclase activator.

Ro 48-8071 fumarate	Others	Cancer
Ro 48-8071 fumarate is an inhibitor of OSC (Oxidosqualene cyclase) with IC₅₀ of appr 6.5 nM.

Vericiguat BAY1021189	Guanylate Cyclase	Cardiovascular Disease
Vericiguat (BAY1021189) is a potent, orally available and soluble guanylate cyclase stimulator.

Cinaciguat BAY 58-2667	Guanylate Cyclase	Cardiovascular Disease
Cinaciguat is an activator of *guanylate cyclase* (sGC)**, and used for acute decompensated heart failure.

Ro 48-8071	Others	Cancer
Ro 48-8071 is an inhibitor of OSC (Oxidosqualene cyclase) with IC₅₀ of appr 6.5 nM.

HY-14181A

Cinaciguat hydrochloride BAY 58-2667 hydrochloride	Guanylate Cyclase	Cardiovascular Disease
Cinaciguat hydrochloride is a potent soluble guanylate cyclase (GC) activator with EC₅₀ of 15 nM in platelets.

HY-14779

Riociguat
BAY 632521
Guanylate Cyclase Cardiovascular Disease

Riociguat is an oral stimulator of soluble guanylate cyclase (sGC) used in the treatment of pulmonary hypertension.
HY-131005

Ehp inhibitor 2
Ephrin Receptor Cancer

Ehp inhibitor 2 is a Eph family tyrosine kinase inhibitor.
HY-78237

Nelociguat
BAY60-4552
Guanylate Cyclase Cardiovascular Disease

Nelociguat (BAY60-4552) is a nitric oxide sensitive soluble guanylate cyclase stimulator.
HY-14927

Lificiguat
YC-1
Guanylate Cyclase Cancer

Lificiguat binds to the β subunit of soluble guanylyl cyclase(sGC) with K_d of 0.6-1.1 μM in the presence of CO.
HY-121879

SHP836
Phosphatase Cancer

SHP836 is a SHP2 allosteric inhibitor, with an IC₅₀ of 12 μM for the full length SHP2.

Riociguat BAY 632521	Guanylate Cyclase	Cardiovascular Disease
Riociguat is an oral stimulator of soluble guanylate cyclase (sGC) used in the treatment of pulmonary hypertension.

Ehp inhibitor 2	Ephrin Receptor	Cancer
Ehp inhibitor 2 is a Eph family tyrosine kinase inhibitor.

Nelociguat BAY60-4552	Guanylate Cyclase	Cardiovascular Disease
Nelociguat (BAY60-4552) is a nitric oxide sensitive soluble guanylate cyclase stimulator.

Lificiguat YC-1	Guanylate Cyclase	Cancer
Lificiguat binds to the β subunit of soluble guanylyl cyclase(sGC) with K_d of 0.6-1.1 μM in the presence of CO.

SHP836	Phosphatase	Cancer
SHP836 is a SHP2 allosteric inhibitor, with an IC₅₀ of 12 μM for the full length SHP2.

HY-17584

Linaclotide	Guanylate Cyclase	Others
Linaclotide is a potent and selective *guanylate cyclase* C** agonist; developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation.

HY-117962A

BI 703704	Guanylate Cyclase	Metabolic Disease
BI 703704 is a potent *soluble guanylate cyclase* (sGC)** activator. BI 703704 inhibits the progression of diabetic nephropathy in the ZSF1 rat.

HY-P0004

Lysipressin Lysine vasopressin; [Lys8]-Vasopressin	Others	Others
Lysipressin is Antidiuretic hormone that have been found in pigs and some marsupial families. Induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase.

HY-101255

ODQ	Guanylate Cyclase Apoptosis	Cancer
ODQ is a potent and selective soluble guanylyl cyclase (sGC, nitric oxide-activated enzyme) inhibitor. ODQ enhances the pro-apoptotic effects of Cisplatin in human mesothelioma cells.

HY-109066

Olinciguat IW-1701	Guanylate Cyclase	Cardiovascular Disease
Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator with concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole cell assay.

HY-109136

Runcaciguat	Guanylate Cyclase	Cardiovascular Disease
Runcaciguat is an orally active stimulator of soluble guanylate cyclase, and is used in the research of cardiovascular and renal diseases combined with selective partial adenosine A1 receptor agonists.

HY-19373

RWJ-445167 3DP-10017	Thrombin Factor Xa	Cardiovascular Disease
RWJ-445167 (3DP-10017) is a dual inhibitor of thrombin and factor Xa with K_i of 4.0 nM and 230 nM, respectively, exhibiting potent antithrombotic activity.

HY-16787

ICA-121431	Sodium Channel	Cardiovascular Disease
ICA-121431 is a nanomolar potent and broad-spectrum voltage-gated sodium channel (Na_v) blocker, shows equipotent selectivity for human Na_v1.1 and Na_v1.3 subtypes with IC₅₀ values of 13 nM and 23 nM, respectively. ICA-121431 shows less potent inhibition of Na_v1.2 (IC₅₀=240 nM) and 1,000 fold selectivity against Na_v1.4, Na_v1.6, and the TTX-resistant human Na_v1.5 and Na_v1.8 channels (IC₅₀s >10 µM).

HY-108741A

Plecanatide acetate	Guanylate Cyclase	Inflammation/Immunology
Plecanatide acetate is a *guanylate cyclase-C (GC-C) receptor* agonist, with an EC₅₀ of 190 nM in T84 cells. Plecanatide acetate shows anti-inflammatory activity in models of murine colitis.

HY-119173

PBD-150
Amyloid-β Neurological Disease

PBD-150 is a human glutaminyl cyclase (hQC) Y115E-Y117E variant inhibitor, with a K_i value of 490 nM.

PBD-150	Amyloid-β	Neurological Disease
PBD-150 is a human *glutaminyl cyclase* (hQC) Y115E-Y117E variant inhibitor, with a K_i** value of 490 nM.

HY-111516

MGV354	Guanylate Cyclase	Inflammation/Immunology Cardiovascular Disease
MGV354 is a soluble guanylate cyclase (sGC) activator with EC₅₀s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively.

HY-U00439A

*Protein kinase inhibitors* 1 hydrochloride** (E)-5-((2-Oxo-6'-(piperazin-1-yl)-1,2-dihydro-[3,3'-bipyridin]-5-yl)methylene)thiazolidine-2,4-dione hydrochloride	DYRK	Cancer
Protein kinase inhibitors 1 hydrochloride is a potent HIPK2 inhibitor, with IC₅₀s of 136 and 74 nM for HIPK1 and HIPK2, and a K_d of 9.5 nM for HIPK2.

HY-W012037

8-Hydroxyquinoline hemisulfate 8-Quinolinol hemisulfate	Bacterial Antibiotic	Infection
8-Hydroxyquinoline hemisulfate (8-Quinolinol hemisulfate) is a monoprotic bidentate chelating agent, exhibits antiseptic, disinfectant, and pesticide properties, functioning as a transcription inhibitor.

HY-P1495

Small Cardioactive Peptide B SCPB	Adenylate Cyclase	Neurological Disease Cardiovascular Disease
Small Cardioactive Peptide B (SCP_B), a neurally active peptide, stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with EC₅₀s of 0.1 and 1.0 μM, respectively.

HY-117962

(Rac)-BI 703704	Guanylate Cyclase	Metabolic Disease
(Rac)-BI 703704 is a potent *soluble guanylyl cyclase* (sGC)** activator. (Rac)-BI 703704 reduces progression of renal damage in the ZSF1 rat, and highlight the potential of sGC activation as an effective therapy for diabetic nephropathy.

HY-117917

(Rac)-MGV354	Guanylate Cyclase	Inflammation/Immunology Cardiovascular Disease
(Rac)-MGV354 is the racemate of MGV354. MGV354 is a soluble guanylate cyclase (sGC) activator with EC₅₀s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively.

HY-109039

Praliciguat IW-1973	Guanylate Cyclase	Cardiovascular Disease
Praliciguat (IW-1973) is a potent and orally active soluble guanylate cyclase stimulator, enhances NO signaling, acts as a vasodilator. Praliciguat (IW-1973) stimulates sGC in HEK-293 cells with an EC₅₀ of 197 nM.

HY-135813

LtaS-IN-1	Bacterial	Infection
LtaS-IN-1 (compound 1771) is a potent small-molecule inhibitor of Lipoteichoic acid (LTA) synthesis in multidrug-resistant (MDR) E. faecium and by altering the cell wall morphology. LtaS-IN-1 alone inhibits Enterococcus.spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 combination with antibiotics abolishs multidrug-resistant E. faecium growth almost completely.

HY-125957

A-3 hydrochloride	PKA Casein Kinase CaMK PKC	Others
A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It against PKA (K_i=4.3 µM), casein kinase II (K_i=5.1 µM) and myosin light chain kinase (MLCK) (K_i=7.4 µM). A-3 hydrochloride also inhibits PKC and casein kinase I with K_i values of 47 µM and 80 µM, respectively.

HY-113926

BAY 60-2770	Guanylate Cyclase	Cardiovascular Disease
BAY 60-2770 is a potent, selective, and orally active *soluble guanylyl cyclase* (sGC)** activator. BAY 60-2770 increases the activity of sGC in a nitric oxide-independent manner. BAY 60-2770 shows antifibrotic effect.

HY-P1179

Guanylin(human)	Guanylate Cyclase Endogenous Metabolite	Cancer Endocrinology
Guanylin(human), a 15-amino acid peptide, is an endogenous intestinal guanylate cyclase activator. Guanylin(human) is mainly found in gastrointestinal tract which regulates electrolytead water transport in intestinal and renal epithelia through cyclic GMP-dependent mechanism.

HY-W010791

Adenosine 5'-diphosphate sodium salt	Endogenous Metabolite	Others
Adenosine 5'-diphosphate (ADP) sodium salt is a nucleoside diphosphate, which is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate sodium salt induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P_2T-purinoceptors.

HY-P1179A

Guanylin(human) TFA	Guanylate Cyclase Endogenous Metabolite
Guanylin(human) TFA, a 15-amino acid peptide, is an endogenous intestinal guanylate cyclase activator. Guanylin(human) TFA is mainly found in gastrointestinal tract which regulates electrolytead water transport in intestinal and renal epithelia through cyclic GMP-dependent mechanism.

HY-W010918

Adenosine 5'-diphosphate Adenosine diphosphate; ADP	Endogenous Metabolite	Others
Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P_2T-purinoceptors.

HY-101918

DS-1040 Tosylate	Others	Cardiovascular Disease
DS-1040 Tosylate is an orally active, selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) with IC₅₀s of 5.92 nM and 8.01 nM for human and rat TAFIa. DS-1040 Tosylate is a fibrinolysis enhancer for thromboembolic diseases.

HY-18728

STF-31
GLUT Autophagy Cancer

STF-31 is a selective inhibitor of glucose transporter 1 (GLUT1), with an IC₅₀ of 1μM^[1][2].

HY-W062836

BAY 41-8543	Guanylate Cyclase	Cardiovascular Disease
BAY 41-8543 is an orally active, nitric oxide (NO)-independent stimulator of *soluble guanylyl cyclase* (sGC)**. BAY 41-8543 has vasodilator activity in the pulmonary and systemic vascular beds in the rat. BAY 41-8543 has antiplatelet effects and has the potential for cardiovascular diseases research.

HY-N7395

Cyclic ADP-ribose cADPR	Calcium Channel TRP Channel Endogenous Metabolite	Infection Endocrinology Inflammation/Immunology Neurological Disease Cardiovascular Disease
Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD⁺ by a ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels.

HY-15583

Auristatin F	Microtubule/Tubulin ADC Cytotoxin	Cancer
Auristatin F is a potent cytotoxin. Auristatin F, a potent microtubule inhibitor and vascular damaging agent (VDA), can be used in antibody-drug conjugates (ADC).

HY-12379

NS-2028	Guanylate Cyclase	Inflammation/Immunology
NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor with IC₅₀ values of 30 nM and 200 nM for basal and NO-stimulated enzyme activity. NS-2028 inhibits soluble Guanylyl Cyclase activity in homogenates of mouse cerebellum and neuronal NO synthase with IC₅₀ values of 17 nM and 20 nM. NS-2028 inhibits 3-morpholino-sydnonimine (SIN-1)-elicited formation of cyclic GMP in human cultured umbilical vein endothelial cells with an IC₅₀ of 30 nM. NS-2028 is commonly used in the research of nitric oxide signaling pathways, it inhibits NO-dependent relaxant responses in non-vascular smooth muscle completely (1 μM). NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability.

HY-14536

Methylene Blue Basic Blue 9; Methylthioninium chloride; CI-52015	Guanylate Cyclase Monoamine Oxidase NO Synthase Parasite	Cancer Infection Neurological Disease
Methylene blue (Basic Blue 9) is a *guanylyl cyclase* (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS)** inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. Methylene blue has antinociception, antimalarial, antidepressant and anxiolytic activity effects. Methylene Blue has the potential for methemoglobinemias, neurodegenerative disorders and ifosfamide-induced encephalopathytreatment.

HY-122470

Stampidine	Reverse Transcriptase HIV	Infection
Stampidine is a nucleoside reverse transcriptase inhibitor (NRTI) with potent and broad-spectrum anti-HIV activity. Stampidine inhibits the laboratory HIV-1 strain HTLV_IIIB (B-envelope subtype) and primary clinical isolates with IC₅₀s of 1 nM and 2 nM, respectively. Stampidine also inhibits NRTI-resistant primary clinical isolates and NNRTI-resistant clinical isolates with IC₅₀s of 8.7 nM and 11.2 nM, respectively.

HY-103193

NKH477 Colforsin dapropate hydrochloride	Adenylate Cyclase	Cardiovascular Disease
NKH477 (Colforsin dapropate hydrochloride) is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 directly activates the catalytic unit of adenylate cyclase and increases intracellular cAMP. NKH477 exerts an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts.

HY-Y0265

Isatin Indoline-2,3-dione	Monoamine Oxidase Apoptosis	Cancer Neurological Disease Cardiovascular Disease
Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC₅₀ of 3 μM. Also binds to central benzodiazepine receptors (IC₅₀ against clonazepam, 123 μM). Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity. Shows effect on the serotonergic system.

HY-B1359

Methylene blue trihydrate C.I. Basic Blue 9 trihydrate	Guanylate Cyclase Monoamine Oxidase NO Synthase Parasite	Cancer Infection Neurological Disease
Methylene blue trihydrate (C.I. Basic Blue 9 trihydrate) is a *guanylyl cyclase* (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS)** inhibitor. Methylene blue trihydrate is a vasopressor and is often used as a dye in several medical procedures. Methylene blue trihydrate has antinociception, antimalarial, antidepressant and anxiolytic activity effects. Methylene Blue trihydrate has the potential for methemoglobinemias, neurodegenerative disorders and ifosfamide-induced encephalopathytreatment.

HY-11007

GNF-2
Bcr-Abl SARS-CoV Cancer

GNF-2 is a highly selective, allosteric, non-ATP competitive inhibitor of Bcr-Abl. GNF-2 inhibits Ba/F3.p210 proliferation with an IC₅₀ of 138 nM .

HY-122872

MKK7-COV-9	p38 MAPK	Cancer
MKK7-COV-9 is a potent and selective covalent inhibitor of MKK7 and targets a specific protein–protein interaction of MKK7. MKK7-COV-9 blocks primary B cell activation in response to LPS with an EC₅₀ of 4.98 μM.

HY-120944

BAY-7598	MMP	Inflammation/Immunology
BAY-7598 is a potent, orally bioavailable, and selective MMP12 inhibitor probe with IC₅₀s of 0.085, 0.67 and 1.1 nM for human MMP12, murine MMP12, and rat MMP12, respectively.

Cat. No.	Product Name	Type

HY-14536

Methylene Blue

Basic Blue 9; Methylthioninium chloride; CI-52015

Chromogenic Assays

Methylene blue (Basic Blue 9) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. Methylene blue has antinociception, antimalarial, antidepressant and anxiolytic activity effects. Methylene Blue has the potential for methemoglobinemias, neurodegenerative disorders and ifosfamide-induced encephalopathytreatment.

Cat. No.	Product Name	Target	Research Area

HY-P0252

α-Melanocyte-Stimulating Hormone (MSH), amide	Adenylate Cyclase	Metabolic Disease
α-Melanocyte-Stimulating Hormone (MSH), amide stimulates melanocortin 1 receptor that results in the activation of **adenylyl cyclase**.

HY-P1852

TIP 39, Tuberoinfundibular Neuropeptide	Adenylate Cyclase	Neurological Disease
TIP 39, Tuberoinfundibular Neuropeptide is a neuropeptide and parathyroid hormone 2 receptor (PTH2R) agonist. TIP 39 is highly conserved among species. TIP39 from all species activates adenylyl cyclase and elevates intracellular calcium levels through parathyroid hormone 2 receptor (PTH2R).

HY-P1495

Small Cardioactive Peptide B SCPB	Adenylate Cyclase	Neurological Disease Cardiovascular Disease
Small Cardioactive Peptide B (SCP_B), a neurally active peptide, stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with EC₅₀s of 0.1 and 1.0 μM, respectively.

HY-P1179

Guanylin(human)	Guanylate Cyclase Endogenous Metabolite	Cancer Endocrinology
Guanylin(human), a 15-amino acid peptide, is an endogenous intestinal guanylate cyclase activator. Guanylin(human) is mainly found in gastrointestinal tract which regulates electrolytead water transport in intestinal and renal epithelia through cyclic GMP-dependent mechanism.

HY-P1179A

Guanylin(human) TFA	Guanylate Cyclase Endogenous Metabolite
Guanylin(human) TFA, a 15-amino acid peptide, is an endogenous intestinal guanylate cyclase activator. Guanylin(human) TFA is mainly found in gastrointestinal tract which regulates electrolytead water transport in intestinal and renal epithelia through cyclic GMP-dependent mechanism.

HY-P0221

PACAP (1-38), human, ovine, rat Pituitary Adenylate cyclase Activating Polypeptide 38	Peptides	Neurological Disease
PACAP (1-38), human, ovine, rat is a neuropeptide with 38 amino acid residues. PACAP (1-38) binds to PACAP type I receptor, PACAP type II receptor VIP₁, and PACAP type II receptor VIP₂ with IC₅₀s of 4 nM, 2 nM, and 1 nM, respectively.

HY-P0221A

PACAP (1-38), human, ovine, rat TFA Pituitary Adenylate cyclase Activating Polypeptide 38 TFA	Peptides	Neurological Disease
PACAP (1-38), human, ovine, rat TFA is a neuropeptide with 38 amino acid residues. PACAP (1-38) binds to PACAP type I receptor, PACAP type II receptor VIP₁, and PACAP type II receptor VIP₂ with IC₅₀s of 4 nM, 2 nM, and 1 nM, respectively.

Cat. No.	Product Name	Target	Category

HY-15371

Forskolin Coleonol; Colforsin	Adenylate Cyclase FXR Autophagy	Terpenoids and Glycosides
Forskolin (Coleonol) is a potent adenylate cyclase activator with an IC₅₀ of 41 nM and an EC₅₀ of 0.5 μM for type I adenylyl cyclase. Forskolin is also an inducer of intracellular cAMP formation. Forskolin induces differentiation of various cell types and activates pregnane X receptor (PXR) and *FXR. Forskolin exerts a inotropic effect on the heart, and has platelet antiaggregatory and antihypertensive actions. Forskolin also induces autophagy*.

HY-16561

Resveratrol trans-Resveratrol; SRT501	IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic	Phenols
Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, **Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1** activator. Resveratrol is a potent pregnane X receptor (PXR) inhibitor.

HY-P0004

Lysipressin Lysine vasopressin; [Lys8]-Vasopressin	Others	Acids and Aldehydes
Lysipressin is Antidiuretic hormone that have been found in pigs and some marsupial families. Induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase.

HY-W010791

Adenosine 5'-diphosphate sodium salt	Endogenous Metabolite	Acids and Aldehydes
Adenosine 5'-diphosphate (ADP) sodium salt is a nucleoside diphosphate, which is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate sodium salt induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P_2T-purinoceptors.

HY-W010918

Adenosine 5'-diphosphate Adenosine diphosphate; ADP	Endogenous Metabolite	Alkaloids Acids and Aldehydes
Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P_2T-purinoceptors.

HY-N7395

Cyclic ADP-ribose cADPR	Calcium Channel TRP Channel Endogenous Metabolite	Acids and Aldehydes
Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD⁺ by a ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels.

HY-Y0265

Isatin Indoline-2,3-dione	Monoamine Oxidase Apoptosis	Alkaloids
Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC₅₀ of 3 μM. Also binds to central benzodiazepine receptors (IC₅₀ against clonazepam, 123 μM). Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity. Shows effect on the serotonergic system.

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