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Aggrecan Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Biochemical Assay Reagents (1) P2Y Receptor (1)
By Research Areas:	Inflammation/Immunology (1)

2

Inhibitors & Agonists

3

Biochemical Assay Reagents

1

Peptides

Cat. No.	Product Name	Target	Research Areas

Collagenase, Type I EC 3.4.24.3	Biochemical Assay Reagents	Others
Collagenase, Type I is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type I breaks down collagens 1, 3, 7, 8, 10, gelatin, proteoglycans, aggrecan. Unit Definition: One unit releases 1 μmolar of L leucine equivalent from collagen in 5 hours at 37oC, pH 7.5.

NF157	P2Y Receptor	Inflammation/Immunology
NF157 is a highly selective nanomolar P2Y11 antagonist with a pK_i of 7.35. The IC₅₀s are 463 nM, 1811 µM, 170 µM for P2Y11 (K_i=44.3 nM), P2Y1 (K_i=187 µM), P2Y2 (K_i=28.9 µM), respectively. NF157, significantly reduces expression of metalloproteinase (MMP)-3, MMP-13, can be used in the treatment of osteoarthritis (OA).

Cat. No.	Product Name	Type

Cat. No.	Product Name	Target	Research Area

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