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Results for "

AhR Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aryl Hydrocarbon Receptor (23) Androgen Receptor (1) Apoptosis (3) Autophagy (1) Bacterial (1) Checkpoint Kinase (Chk) (1) COX (2) E1/E2/E3 Enzyme (1) Endogenous Metabolite (1) ERK (2) Estrogen Receptor/ERR (2) Ferroptosis (1) Fungal (1) Glucosidase (1) HIF/HIF Prolyl-Hydroxylase (2) Isotope-Labeled Compounds (1) JAK (1) Lipoxygenase (1) MDM-2/p53 (1) MEK (1) NF-κB (1) PD-1/PD-L1 (1) Sodium Channel (1) STAT (1) VEGFR (1)
By Research Areas:	Cancer (19) Endocrinology (3) Infection (1) Inflammation/Immunology (7) Metabolic Disease (2) Neurological Disease (4)

By Targets:

Aryl Hydrocarbon Receptor (23)

Androgen Receptor (1)

Apoptosis (3)

Autophagy (1)

Bacterial (1)

Checkpoint Kinase (Chk) (1)

COX (2)

E1/E2/E3 Enzyme (1)

Endogenous Metabolite (1)

ERK (2)

Estrogen Receptor/ERR (2)

Ferroptosis (1)

Fungal (1)

Glucosidase (1)

HIF/HIF Prolyl-Hydroxylase (2)

Isotope-Labeled Compounds (1)

JAK (1)

Lipoxygenase (1)

MDM-2/p53 (1)

MEK (1)

NF-κB (1)

PD-1/PD-L1 (1)

Sodium Channel (1)

STAT (1)

VEGFR (1)

By Research Areas:

Cancer (19)

Endocrinology (3)

Infection (1)

Inflammation/Immunology (7)

Metabolic Disease (2)

Neurological Disease (4)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Aryl Hydrocarbon Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-141609

AHR antagonist 5 free base	Aryl Hydrocarbon Receptor	Cancer
AHR antagonist 5 free base is a selective and orally active aryl hydrocarbon receptor (AHR) inhibitor. AHR antagonist 5 free base effectively blocks AHR from translocating from the cytoplasm to the nucleus. AHR antagonist 5 free base is highly selective for AHR over other receptors, transporters, and kinases .

HY-119960

AHR-10037	COX	Inflammation/Immunology
AHR-10037 is a non-steroidal anti-inflammatory agent with low gastric toxicity. AHR-10037 is a prodrug converted in vivo to a cyclooxygenase inhibitor .

HY-116638

AHR-5333	Lipoxygenase	Endocrinology
AHR-5333 is a selective human blood neutrophil 5-lipoxygenase inhibitor. AHR-5333 exhibits potent, long-acting activity in rat and guinea pig in vivo models of immediate hypersensitivity .

HY-135671

AhR modulator-1	Aryl Hydrocarbon Receptor VEGFR Estrogen Receptor/ERR	Endocrinology Cancer
AhR modulator-1 (compound 6-MCDF) is a selective and orally active aryl hydrocarbon receptor (AhR) modulator. AhR modulator-1 inhibits metastasis, in part, by inhibiting prostatic VEGF production prior to tumor formation. AhR modulator-1 also possess anti-estrogenic properties in rat uterus .

HY-136220A

AHR antagonist 5 hemimaleate	Aryl Hydrocarbon Receptor	Cancer
AHR antagonist 5 hemimaleate, a potent and orally active aryl hydrocarbon receptor *(AHR)* antagonist, has an IC₅₀ of < 0.5 µΜ. AHR antagonist 5 hemimaleate significantly inhibits tumor growth combined with checkpoint inhibitor anti-PD-1 (WO2018195397, example 39) .

HY-136220

AHR antagonist 5	Aryl Hydrocarbon Receptor	Cancer
AHR antagonist 5, a potent and orally active aryl hydrocarbon receptor *(AHR)* antagonist extracted from patent WO2018195397, example 39, has an IC₅₀ of < 0.5 µΜ. AHR antagonist 5 significantly inhibits tumor growth combined with checkpoint inhibitor anti-PD-1 .

HY-111450

CB7993113	Aryl Hydrocarbon Receptor	Cancer
CB7993113 is a potent AHR antagonist, with an IC₅₀ of 0.33 μM. CB7993113 directly binds AHR protein and blocks AHR nuclear translocation. CB7993113 inhibits polycyclic aromatic hydrocarbon (PAH)- and TCDD-induced reporter activity by 75% and 90% respectively .

HY-W338764

AHR agonist 3	Apoptosis Aryl Hydrocarbon Receptor	Cancer
AHR agonist 3 is an aryl hydrocarbon receptor (AhR) agonist, that can induces cell cycle arrest or apoptosis via activation of tumor-suppressive transcriptional programs. AHR agonist 3 inhibits triple-negative breast cancer (TNBC) stem cell growth via AhR while exhibits minimal cytotoxicity against normal human primary cells and can be used for cancer research .

HY-114740

β-Naphthoflavone 1 Publications Verification 5,6-Benzoflavone; beta-NF	Aryl Hydrocarbon Receptor Apoptosis	Neurological Disease Cancer
β-Naphthoflavone is a non-carcinogenic *AhR* agonist as a positive control for the induction of AhR transcriptional activity . β-Naphthoflavone inhibits hydrogen peroxide-induced apoptosis .

HY-12684

CH-223191 50+ Cited Publications	Aryl Hydrocarbon Receptor	Cancer
CH-223191 is a potent and specific antagonist of aryl hydrocarbon receptor (AhR). CH-223191 inhibits TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibits TCDD-induced luciferase activity with an IC₅₀ of 0.03 μM .

HY-17357

Nepafenac

AhR 9434; AL 6515
COX Bacterial Inflammation/Immunology

Nepafenac(AHR 9434; AL 6515; Nevanac) is a selective COX-2 inhibitor; is prodrug of Amfenac.

Nepafenac AhR 9434; AL 6515	COX Bacterial	Inflammation/Immunology
Nepafenac(AHR 9434; AL 6515; Nevanac) is a selective COX-2 inhibitor; is prodrug of Amfenac.

HY-135750

VAF347 2 Publications Verification	Aryl Hydrocarbon Receptor	Inflammation/Immunology
VAF347 is a cell permeable and highly affinity aryl hydrocarbon receptor (AhR) agonist and induces *AhR* signaling. VAF347 inhibits the development of CD14 ⁺CD11b ⁺ monocytes from granulo-monocytic (GM stage) precursors. VAF347 has anti-inflammatory effects .

HY-B0311

Carbidopa (S)-(-)-Carbidopa	Aryl Hydrocarbon Receptor	Neurological Disease Cancer
Carbidopa ((S)-(-)-Carbidopa), a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa inhibits pancreatic cancer cell and tumor growth .

HY-B0311A

Carbidopa monohydrate (S)-(-)-Carbidopa monohydrate
Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth .

HY-15484

Pifithrin-α hydrobromide 50+ Cited Publications Pifithrin hydrobromide; PFTα hydrobromide	MDM-2/p53 Aryl Hydrocarbon Receptor Ferroptosis Apoptosis	Cancer
Pifithrin-α hydrobromide is a p53 inhibitor which blocks its transcriptional activity and prevents cells from apoptosis. Pifithrin-α hydrobromide is also an aryl hydrocarbon receptor (AhR) agonist.

HY-N4095

Brevifolincarboxylic acid	Aryl Hydrocarbon Receptor Glucosidase	Metabolic Disease Inflammation/Immunology
Brevifolincarboxylic acid is extracted from Polygonum capitatum , has inhibitory effect on the aryl hydrocarbon receptor (AhR) . Brevifolincarboxylic acid is an α-glucosidase inhibitor with an IC₅₀ of 323.46 μM .

HY-N6264

26-Deoxyactein	Aryl Hydrocarbon Receptor ERK	Metabolic Disease
26-Deoxyactein is a constituent isolated from Cimicifuga racemosa, prevents TCDD-induced osteoblasts damage. 26-Deoxyactein inhibits increased AhR, CYP1A1 and ERK levels .

HY-16031B

AFP464 dihydrochloride NSC710464 dihydrochloride	HIF/HIF Prolyl-Hydroxylase	Cancer
AFP464 (dihydrochloride) (NSC710464 (dihydrochloride)) is the hydrochloride form of AFP464 and is a potent HIF-1α inhibitor with an IC₅₀ value of 0.25 μM. It is also an activator of aryl hydrocarbon receptor (AhR).

HY-12028

PD98059 Maximum Cited Publications 285 Publications Verification	MEK ERK Aryl Hydrocarbon Receptor Autophagy	Cancer
PD98059 is a potent and selective MEK inhibitor with an IC₅₀ of 5 µM. PD98059 binds to the inactive form of MEK, thereby preventing the activation of MEK1 (IC₅₀ of 2-7 µM) and MEK2 (IC₅₀ of 50 µM) by upstream kinases. PD98059 is a ERK1/2 signaling inhibitor. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR), and suppresses TCDD binding (IC₅₀ of 4 μM) and *AHR* transformation (IC₅₀ of 1 μM). PD98059 also inhibits Mycobacterium bovis Bacillus CalmetteGuerin (BCG)-induced autophagy .

HY-N0170

Indole-3-carbinol 5+ Cited Publications I3C; 3-Indolemethanol	NF-κB Aryl Hydrocarbon Receptor E1/E2/E3 Enzyme Endogenous Metabolite	Cancer
Indole-3-carbinol (I3C) inhibits NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1).

HY-16031

AFP464 free base NSC710464 free base	HIF/HIF Prolyl-Hydroxylase	Cancer
AFP464 free base (NSC710464 free base), is an active HIF-1α inhibitor with an IC₅₀ of 0.25 μM, also is a potent aryl hydrocarbon receptor (AhR) activator.

HY-134217

KYN-101	Aryl Hydrocarbon Receptor	Cancer
KYN-101 is a potent, selective and orally active *AHR* inhibitor. KYN-101 decreases the CYP1A1 mRNA expression. KYN-101 shows anti-cancer activity .

HY-N10295

Flavipin	Aryl Hydrocarbon Receptor	Inflammation/Immunology
Flavipin is an aryl hydrocarbon receptor *(Ahr)* agonist that induces the expression of Ahr downstream genes in mouse CD4 ⁺ T cells and CD11b ⁺ macrophages. Flavipin inhibits the stabilizing function of Arid5a on Il23a 3′UTR, a newly identified target mRNA . Flavipin exhibits the DPPH free radical scavenging ability with IC₅₀ value of 7.2 μM, and has potent α-glucosidase inhibition with IC₅₀ value of 33.8 μM .

HY-117102

ANI-7	Aryl Hydrocarbon Receptor Checkpoint Kinase (Chk)	Cancer
ANI-7 is an activator of aryl hydrocarbon receptor (AhR) pathway. ANI-7 inhibits the growth of multiple cancer cells, and potently and selectively inhibits the growth of MCF-7 breast cancer cells with a GI₅₀ of 0.56 μM. ANI-7 induces CYP1-metabolizing mono-oxygenases by activating *AhR* pathway, and also induces DNA damage, checkpoint Kinase 2 (Chk2) activation, S-phase cell cycle arrest, and cell death in sensitive breast cancer cell lines .

HY-B0311AS

Carbidopa-d3 monohydrate (S)-(-)-Carbidopa-d₃ (monohydrate)	Aryl Hydrocarbon Receptor	Neurological Disease Cancer
Carbidopa-d₃ (monohydrate) is the deuterium labeled Carbidopa monohydrate. Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth[1][2].

HY-B0311S1

Carbidopa-d3-1 (S)-(-)-Carbidopa-d₃	Aryl Hydrocarbon Receptor Isotope-Labeled Compounds	Neurological Disease
Carbidopa-d3-1 is the deuterium labeled Carbidopa (HY-B0311). Carbidopa, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa inhibits pancreatic cancer cell and tumor growth .

HY-18619

YL-109 1 Publications Verification	Aryl Hydrocarbon Receptor	Cancer
YL-109 is an antitumor agent that can induce carboxyl terminus of Hsp70-interacting protein (CHIP) expression through aryl hydrocarbon receptor (AhR) signaling. YL-109 has ability to inhibit breast cancer cell growth and invasiveness .

HY-B0845

Prochloraz BTS 40542	Fungal Estrogen Receptor/ERR Androgen Receptor Aryl Hydrocarbon Receptor	Infection Endocrinology
Prochloraz is an imidazole antifungal. Prochloraz is as an estrogen receptor (ER) and androgen receptor (AR) antagonist and an aromatase inhibitor with IC₅₀ values of 25 μM, 4 μM and 0.3 μM, respectively. Prochloraz is able to activate the aryl hydrocarbon receptor (AhR) having an EC₅₀ of 1 μM .

HY-125019

iJak-381	JAK STAT	Inflammation/Immunology
iJak-381 is a JAK1/2 inhibitor with anti-inflammatory activity. iJak-381 blocks IL-13 signaling and also inhibits IL-4 and IL-6 signaling pathways. iJak-381 also reduced p-STAT6 levels and inhibited the influx of inflammatory cells into the lungs of mice. iJak-381 inhibits airway hyperresponsiveness (AHR) .

HY-N12537A

(2R,3S)-PD-1/PD-L1-IN-38	Aryl Hydrocarbon Receptor PD-1/PD-L1	Cancer
(2R,3S)-PD-1/PD-L1-IN-38 (Compound (±)-13e) is an orally active Ah receptor (AhR) antagonist with in vivo and in vitro anticancer activity. (2R,3S)-PD-1/PD-L1-IN-38 promotes the secretion of INF-γ by CD8 ⁺T cells and inhibits the signal transduction of PD-1/PD-L1 .

HY-12545

Brevetoxin-3 PbTx-3	Sodium Channel	Inflammation/Immunology
Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na ⁺ channel activator and has multiple active centers (A-ring lactone, C-42 of R side chain) . Brevetoxin-3 (PbTx-3) has a high affinity to site 5 of the voltage-sensitive Na ⁺ channels, inhibits the inactivation of Na ⁺ channels and prolongs the mean open time of these channels. Brevetoxin-3 (PbTx-3) repeated exposures can lead to prolonged airway hyperresponsiveness (AHR) and lung inflammation .

Cat. No.	Product Name	Category	Target	Chemical Structure