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Aldehyde Dehydrogenase (ALDH)

" in MCE Product Catalog:

By Targets:	Aldehyde Dehydrogenase (ALDH) (18) Apoptosis (1) Interleukin Related (1) Pyroptosis (1)
By Research Areas:	Cancer (12) Cardiovascular Disease (1) Metabolic Disease (5) Neurological Disease (1)

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Targets Recommended: Aldehyde Dehydrogenase (ALDH) Lactate Dehydrogenase Dihydroorotate Dehydrogenase Isocitrate Dehydrogenase (IDH) Methylenetetrahydrofolate Dehydrogenase (MTHFD) Phosphoglycerate Dehydrogenase (PHGDH) PDHK 15-PGDH 17β-HSD 11β-HSD

Cat. No.	Product Name	Target	Research Areas

HY-P2947

Aldehyde dehydrogenase (NAD(P)) ALDH	Aldehyde Dehydrogenase (ALDH)	Others
Aldehyde dehydrogenase NAD(P) (ALDH) catalyzes the oxidation of aldehydes into their corresponding carboxylic acids with the concomitant reduction of the cofactor NAD(P) into NAD(P)H, is often used in biochemical studies. The aldehyde dehydrogenases (ALDHs) are one of many enzyme systems the body utilizes to alleviate aldehyde stress.

HY-126003

ALDH1A1-IN-2	Aldehyde Dehydrogenase (ALDH)	Cancer
ALDH1A1-IN-2 is a potent inhibitor of aldehyde dehydrogenase 1a1 (aldh1a1). Aldehyde dehydrogenases (ALDH) constitute a family of enzymes that play a critical role in oxidizing various cytotoxic xenogenic and biogenic aldehydes. ALDH1A1-IN-2 has the potential for the research of cancer, inflammation, or obesity (extracted from patent WO2019089626A1, compound 295).

HY-148617

ALDH2 modulator 1	Aldehyde Dehydrogenase (ALDH)	Metabolic Disease
ALDH2 modulator 1 is a potent and orally active **aldehyde dehydrogenase-2 (ALDH2)** modulator. ALDH2 modulator 1 reduces blood alcohol levels in mice.

HY-107030

Nitrefazole EMD-15700	Aldehyde Dehydrogenase (ALDH)	Metabolic Disease
Nitrefazole is a 4-nitroimidazole derivative with strong and long lasting inhibition of **aldehyde dehydrogenase (ALDH)**, an enzyme involved in the metabolism of alcohol.

HY-19801

CVT-10216	Aldehyde Dehydrogenase (ALDH)	Neurological Disease
CVT-10216 is a highly selective, reversible **aldehyde dehydrogenase-2 (ALDH-2) inhibitor with an IC₅₀** of 29 nM. CVT-10216 also has inhibitory effect of ALDH-1 with an IC₅₀ of 1.3 μM. CVT-10216 can reduce excessive alcohol drinking in alcohol-preferring rats and exhibit anxiolytic effects.

HY-110294

CM037
A37
Aldehyde Dehydrogenase (ALDH) Cancer

CM037 is a selective inhibitor of ALDH1A1 (aldehyde dehydrogenase 1A1) with an IC₅₀ of 4.6 µM.

CM037 A37	Aldehyde Dehydrogenase (ALDH)	Cancer
CM037 is a selective inhibitor of *ALDH1A1* (aldehyde dehydrogenase 1A1) with an IC₅₀ of 4.6 µM.

HY-144669

ALDH1A3-IN-2	Aldehyde Dehydrogenase (ALDH)	Cancer
ALDH1A3-IN-2 (Compound 15) is a potent inhibitor of *ALDH1A3* with an IC₅₀ of 1.29 μM. Aldehyde dehydrogenases (ALDHs) are overexpressed in various tumor types including prostate cancer. ALDH1A3-IN-2 has the potential for the research of cancer diseases.

HY-144671

ALDH3A1-IN-2	Aldehyde Dehydrogenase (ALDH)	Cancer
ALDH3A1-IN-2 (Compound 19) is a potent inhibitor of *ALDH3A1* with an IC₅₀ of 1.29 μM. Aldehyde dehydrogenases (ALDHs) are overexpressed in various tumor types including prostate cancer. ALDH3A1-IN-2 has the potential for the research of cancer diseases.

HY-W016645

4-Diethylaminobenzaldehyde	Aldehyde Dehydrogenase (ALDH)	Cancer
4-Diethylaminobenzaldehyde is a reversible **aldehyde dehydrogenases (ALDHs) inhibitor, with a K_i** of 4 nM for ALDH1. 4-Diethylaminobenzaldehyde displays potent anti-androgenic effect (IC₅₀= 1.71μM).

HY-112278

NCT-506
Aldehyde Dehydrogenase (ALDH) Cancer

NCT-506 is an orally bioavailable aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with an IC₅₀ of 7 nM.

NCT-506	Aldehyde Dehydrogenase (ALDH)	Cancer
NCT-506 is an orally bioavailable aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with an IC₅₀ of 7 nM.

HY-135841

CM10	Aldehyde Dehydrogenase (ALDH)	Cancer Metabolic Disease
CM10 is a potent and selective aldehyde dehydrogenase 1A (ALDH1A) family inhibitor, with IC₅₀s of 1700, 740, and 640 nM for ALDH1A1, ALDH1A2, and ALDH1A3, respectively. CM10 does not inhibit any of the other ALDH family members. CM10 can regulate metabolism and has anti-cancer activity.

HY-122577

EN40
Aldehyde Dehydrogenase (ALDH) Cancer

EN40 is a potent, selective aldehyde dehydrogenase 3A1 (ALDH3A1) inhibitor as a covalent ligand, exhibits an IC₅₀ value of 2 uM

EN40	Aldehyde Dehydrogenase (ALDH)	Cancer
EN40 is a potent, selective **aldehyde dehydrogenase 3A1 (ALDH3A1) inhibitor as a covalent ligand, exhibits an IC₅₀** value of 2 uM

HY-146240

ALDH1A1-IN-3	Aldehyde Dehydrogenase (ALDH)	Metabolic Disease
ALDH1A1-IN-3 (compound 57) is an excellent and selective **aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitor with an IC₅₀** value of 0.379 μM. ALDH1A1-IN-3 can effectively improve glucose consumption in HepG2 cells. ALDH1A1-IN-3 can be used for researching glucose metabolism improvement.

HY-18768

NCT-501	Aldehyde Dehydrogenase (ALDH)	Cancer
NCT-501 is a potent and selective theophylline-based inhibitor of **aldehyde dehydrogenase 1A1 (ALDH1A1), inhibits hALDH1A1 with IC₅₀** of 40 nM, typically shows better selectivity over other ALDH isozymes and other dehydrogenases (hALDH1B1, hALDH3A1, and hALDH2, IC₅₀ >57 μM).

HY-76006

3-Hydroxybenzaldehyde	Aldehyde Dehydrogenase (ALDH)	Cardiovascular Disease
3-Hydroxybenzaldehyde is a precursor compound for phenolic compounds, such as Protocatechualdehyde (HY-N0295). 3-Hydroxybenzaldehyde is a substrate of **aldehyde dehydrogenase (ALDH)** in rats and humans (ALDH2). 3-Hydroxybenzaldehyde has vasculoprotective effects in vitro and in vivo.

HY-18768A

NCT-501 hydrochloride	Aldehyde Dehydrogenase (ALDH)	Cancer
NCT-501 hydrochloride is a potent and selective theophylline-based inhibitor of **aldehyde dehydrogenase 1A1 (ALDH1A1), inhibits hALDH1A1 with IC₅₀** of 40 nM, typically shows better selectivity over other ALDH isozymes and other dehydrogenases (hALDH1B1, hALDH3A1, and hALDH2, IC₅₀ >57 μM).

HY-112277

NCT-505	Aldehyde Dehydrogenase (ALDH)	Cancer
NCT-505 is a potent and selective **aldehyde dehydrogenase (ALDH1A1) inhibitor, with an IC₅₀ of 7 nM, and weakly inhibits hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 (IC₅₀**s, >57, 22.8, 20.1, >57 μM).

HY-B0240

Disulfiram Tetraethylthiuram disulfide; TETD	Aldehyde Dehydrogenase (ALDH) Interleukin Related Pyroptosis Apoptosis	Metabolic Disease Cancer
Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase *(ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD)* pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells. Disulfiram + Cu²⁺ increases intracellular ROS levels triggering apoptosis of ovarian cancer stem cells^[1-6].

Cat. No.	Product Name	Type

HY-P2947

Aldehyde dehydrogenase (NAD(P)) ALDH	Enzyme
Aldehyde dehydrogenase NAD(P) (ALDH) catalyzes the oxidation of aldehydes into their corresponding carboxylic acids with the concomitant reduction of the cofactor NAD(P) into NAD(P)H, is often used in biochemical studies. The aldehyde dehydrogenases (ALDHs) are one of many enzyme systems the body utilizes to alleviate aldehyde stress.

Cat. No.	Product Name	Target	Category

HY-76006

3-Hydroxybenzaldehyde	Aldehyde Dehydrogenase (ALDH)	Phenols Monophenols Ketones, Aldehydes, Acids Classification of Application Fields Disease Research Fields Cardiovascular Disease Source classification Plants other families
3-Hydroxybenzaldehyde is a precursor compound for phenolic compounds, such as Protocatechualdehyde (HY-N0295). 3-Hydroxybenzaldehyde is a substrate of **aldehyde dehydrogenase (ALDH)** in rats and humans (ALDH2). 3-Hydroxybenzaldehyde has vasculoprotective effects in vitro and in vivo.

Species:	Human (6)
Tag:	His (6)
Source:	HEK293 (1) Sf9 insect cells (1) P. pastoris (1) E. coli (3)

Cat. No.	Product Name	Species	Source

HY-P75568

ALDH3A1 Protein, Human (sf9, His)
Aldehyde Dehydrogenase, dimeric NADP-preferring; Aldehyde Dehydrogenase 3 member A1; ALDHIII; ALDH3
Human Sf9 insect cells

HY-P7474

ALDH1A1 Protein, Human (His) rHuAldehyde Dehydrogenase 1-A1, His; ALDH-1A1; Aldehyde Dehydrogenase 1-A1	Human	E. coli
ALDH1A1 Protein, Human (His) is a human recombinant ALDH1A1 with an N-terminal Met and His tag produced in E. coli. ALDH1A1 Protein, Human (His) contains 501 amino acids (1-501 a.a.).

HY-P7475

ALDH1A2 Protein, Human (His) rHuAldehyde Dehydrogenase 1-A2, His ; ALDH-1A2; Aldehyde Dehydrogenase 1-A2	Human	E. coli
ALDH1A2 Protein, Human (His) is a human recombinant ALDH1A2 with a N-terminal His tag produced in E. coli. ALDH1A2 Protein, Human (His) expresses the target gene encoding Met1-Ser518.

HY-P7476

ALDH1A3 Protein, Human (His) rHuAldehyde Dehydrogenase 1-A3, His; ALDH-1A3; Aldehyde Dehydrogenase 1-A3	Human	E. coli
ALDH1A3 Protein, Human (His) is a human recombinant ALDH1A3 with a His tag at the N-terminus. ALDH1A3 Protein, Human (His) is produced in E. coli and the target gene encoding Met1-Pro512 is expressed.

HY-P700646

ALDH1A2 Protein, Human (P.pastoris, His)
rHuAldehyde Dehydrogenase 1-A2, His ; ALDH-1A2; Aldehyde Dehydrogenase 1-A2
Human P. pastoris

HY-P7477

ALDH3A1 Protein, Human (HEK293, His) rHuAldehyde Dehydrogenase family 3 member A1, His; ALDH-3A1; Aldehyde Dehydrogenase 3 member A1	Human	HEK293
ALDH3A1 Protein, Human (HEK293, His) is a human recombinant ALDH3A1 with a His tag at the N-terminus. ALDH3A1 Protein, Human (HEK293, His) is expressed in HEK293 cells.

Cat. No.	Product Name	Application	Reactivity

HY-P80536

ALDH1A1 Rabbit mAb ALDH1A1; ALDC; ALDH1; PUMB1; Retinal Dehydrogenase 1; RALDH 1; RalDH1; ALDH-E1; ALHDII; Aldehyde Dehydrogenase family 1 member A1; Aldehyde Dehydrogenase; cytosolic	WB, IHC-P, IP	Human, Mouse
Rabbit Monoclonal Antibody to ALDH1A1

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Aldehyde Dehydrogenase (ALDH)

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Biochemical Assay Reagents

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