Search Result
Results for "
Alkaloid
" in MedChemExpress (MCE) Product Catalog:
1228
Inhibitors & Agonists
5
Biochemical Assay Reagents
30
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
-
- HY-N1633
-
|
Others
|
Others
|
1-Methoxycarbonyl-β-carboline is a natural alkaloid .
|
-
-
- HY-121219
-
-
-
- HY-N1099
-
(+)-Vellosimine; Alkaloid RB 19
|
Others
|
Others
|
Vellosimine ((+)-Vellosimine) is an indole alkaloid. Vellosimine acts as a plant metabolite .
|
-
-
- HY-N11652
-
Alkaloid L20
|
Others
|
Others
|
6α-Hydroxylycopodine (Alkaloid L20) is a Flavonoids product that can be isolated from the herbs of Crotalaria barbata .
|
-
-
- HY-107918
-
-
-
- HY-N9130
-
|
Others
|
Others
|
Indicine (Compound 3) is an alkaloid. Indicine can
reduce pyrrolizine alkaloids (PA) .
|
-
-
- HY-N1999
-
|
Others
|
Others
|
Wilfordine is an alkaloid that isolated from the roots of Tripterygium wilfordii .
|
-
-
- HY-N11979
-
|
Others
|
Others
|
Dihydronitidine is an alkaloid can be extracted from Zanthoxylum rhoifolium .
|
-
-
- HY-N1293
-
NSC72123
|
Others
|
Others
|
Serpentinine (NSC72123) is an alkaloid isolated from Rauwolfia serpentina Benth .
|
-
-
- HY-N3382
-
|
Others
|
Others
|
Shihulimonin A is an alkaloid can be isolated from the fruit of Euodia rutaecarpa (Juss.) Benth .
|
-
-
- HY-N2886
-
Aporheine; S-(+)-Roemerine; d-Isoremerine
|
Others
|
Others
|
Aporeine (Aporheine) is an alkaloid that can be isolated from the aerial parts of p. rhoeas .
|
-
-
- HY-N3177
-
|
Others
|
Others
|
Norglaucine hydrochloride is an alkaloid that can be isolated from Aconitum carmichaelii .
|
-
-
- HY-119478
-
-
-
- HY-N13711
-
|
Others
|
Others
|
Filiformine is a natural oxoaporphine alkaloid .
|
-
-
- HY-121703
-
|
Others
|
Others
|
Rutacridone is an alkaloid that can be cultured from Ruta graveolens L. strain R-19 .
|
-
-
- HY-N3281
-
|
Others
|
Others
|
Methyl chanofruticosinate is an indole alkaloid that can be isolated from Kopsia .
|
-
-
- HY-N3904
-
|
Others
|
Others
|
Fortuneine is a homoerythrina alkaloid from Cephalotaxus fortunei .
|
-
-
- HY-N3735
-
9-Oxodeoxypeganine; Pegenone
|
Others
|
Others
|
Deoxyvasicinone is an alkaloid compound isolated from plants .
|
-
-
- HY-N7722
-
|
Others
|
Others
|
Demethyl Calyciphylline A is an alkaloid. Demethyl Calyciphylline A can be isolated from the fruit of Daphniphyllum longacemosum K. Rosenthal .
|
-
-
- HY-N12244
-
|
Others
|
Others
|
Echitaminic acid (compound 3) is an alkaloid isolated from the trunk bark of Alstonia sellers collected in Timor, Indonesia .
|
-
-
- HY-N11922
-
|
Others
|
Neurological Disease
|
Ipalbidine is an alkaloid extracted from ipomoea Hardwickki Hemsl. Ipalbidine has dose-dependent analgesic effects .
|
-
-
- HY-N3203
-
|
Others
|
Others
|
Neolinine is a diterpenoid alkaloid that can be isolated from the aerial parts of Aconitum carmichaeli .
|
-
-
- HY-N10296
-
|
Bacterial
|
Infection
|
Curvulamine A, an antibacterial alkaloid, shows potent antibacterial activity .
|
-
-
- HY-N8052
-
|
Fungal
|
Infection
|
(-)-Antofine is an alkaloid, a levorotatory Antofine. Antofine is an antifungal compound .
|
-
-
- HY-N11931
-
|
Others
|
Cancer
|
Grandivine A is a steroid alkaloid isolated from Veratrum grandiflorum .
|
-
-
- HY-N12343
-
|
Bacterial
Fungal
|
Infection
|
Tetrahydrorhombifoline is one of quinolizidine alkaloids in the aerial parts of Genista vuralii A. Duran & H. Dural (Fabaceae). The alkaloid extract of G. vuralii has antibacterial and antifungal activities .
|
-
-
- HY-N4031
-
|
Others
|
Others
|
Humantenine is a indole alkaloid compound isolated from Gelsemium elegans .
|
-
-
- HY-117396
-
|
Others
|
Others
|
Isomahanimbine is a natural carbazole alkaloid found in Murraya koenigii (L.) Spreng .
|
-
-
- HY-N10763
-
|
Others
|
Endocrinology
|
N-Methylcorydaldine, an alkaloid, shows promising anti-secretory activity .
|
-
-
- HY-N11803
-
|
Others
|
Others
|
Arundanine is an dimeric alkaloid, which can be isolated from Arundo donax. .
|
-
-
- HY-N3620
-
Conquinamine
|
Parasite
|
Infection
|
Epiquinamine, an alkaloid, has amoebicidal activity (IC50: 12.9 μg/mL) .
|
-
-
- HY-N7625
-
-
-
- HY-N9509
-
|
Others
|
Others
|
Erucifoline is a pyrrolizidine alkaloid that can be found in the aerial parts of Senecio aquaticus .
|
-
-
- HY-N2616
-
-
-
- HY-N8916
-
-
-
- HY-N11918
-
|
Others
|
Others
|
Jervinone is a metabolite of the Veratrum alkaloid, which can be isolated from the mold Cunninghamella echinulata .
|
-
-
- HY-120098A
-
|
Others
|
Cancer
|
Vinleurosine sulfate is an indole alkaloid with antineoplastic activity .
|
-
-
- HY-N8890
-
|
Others
|
Others
|
Demissidine is an alkaloid that can be isolated from potato .
|
-
-
- HY-119831
-
-
-
- HY-N1905
-
|
Others
|
Others
|
4-Methoxy-β-carboline-1-carboxylic acid methylester is an alkaloid with the structure of canthin-6-one and β-carboline .
|
-
-
- HY-N7792
-
|
Others
|
Others
|
Baptifoline is an alkaloid isolated from the rhizome of Caulophyllum thalictroides .
|
-
-
- HY-N1360
-
|
Others
|
Others
|
Rauvotetraphylline A is an alkaloid that can be isolated from Rauvolfia tetraphylla .
|
-
-
- HY-N7771
-
|
Others
|
Others
|
Spartioidine is an alkaloid that can be isolated from Senecio vulgaris .
|
-
-
- HY-W017353
-
-
-
- HY-105797
-
|
Others
|
Infection
|
Apoatropine hydrochloride a tropane alkaloid isolated from Atropa belladonna .
|
-
-
- HY-N1597
-
|
Others
|
Others
|
(19Z)-Normacusine B, Gelsemiurn alkaloids, is a natural product that can be isolated from Gelsemiurn .
|
-
-
- HY-N9794
-
|
Others
|
Inflammation/Immunology
|
Isoboldine is a pyridine alkaloid. Isoboldine effectively alleviates inflammation and joint destruction in collagen-induced arthritis in mice .
|
-
-
- HY-N10099
-
|
Others
|
Others
|
Forestine is a natural C19-diterpenoid alkaloid found in the roots of Aconitum forrestii Stapf .
|
-
-
- HY-133905
-
|
Others
|
Others
|
Pandamine is a natural alkaloid that can be extracted from Panda oleosa .
|
-
-
- HY-N1918
-
Adonifoline
|
Others
|
Others
|
(+)-Adonifoline (Adonifoline) is an alkaloid that can be isolated from Adonis vernalis .
|
-
- HY-N1245
-
|
Others
|
Others
|
Sarpagine is an alkaloid that can be isolated from Colombian Rauwolfia hirsufa .
|
-
- HY-N3858
-
|
Others
|
Inflammation/Immunology
|
Erythristemine is an alkaloid that can be isolated from Erythrina lysistemon. Erythristemine has weak DPPH radical scavenging properties .
|
-
- HY-N3709
-
|
Others
|
Cancer
|
Dehydrocrebanine is an alkaloid that can be isolated from the tuber and leaves of Stephania venosa. Dehydrocrebanine has in vitro anti-cancer activity .
|
-
- HY-N6243
-
-
- HY-N7708
-
-
- HY-22385A
-
-
- HY-N3700
-
Rutaceline
|
Others
|
Others
|
Decarine is a alkaloid which can be isolated from Zanthoxylum simulans .
|
-
- HY-W707850
-
|
Others
|
Others
|
N-trans-Feruloylputrescine is an alkaloid that can be isolated from Magnolia officinalis .
|
-
- HY-N12157
-
|
Others
|
Others
|
Noratherosperminine is an alkaloid that can be isolated from the stem bark of Cryptocarya nigra .
|
-
- HY-N10302
-
-
- HY-117190
-
|
Others
|
Cancer
|
Pseudolycorine is an Amaryllidaceae alkaloid with anticancer activity .
|
-
- HY-N3610
-
|
nAChR
|
Neurological Disease
|
Coclaurine is a class of tetrahydroisoquinoline alkaloids that can be isolated from Sarcopetalum harveyanum. Coclaurine is a nicotinic acetylcholine receptor (nAChRs) antagonist .
|
-
- HY-N2384
-
|
Parasite
|
Infection
|
Febrifugine is a quinazolinone alkaloid found in the roots and leaves of Dichroa febrifuga, with antimalarial activity .
|
-
- HY-N2384A
-
|
Parasite
|
Infection
|
Febrifugine dihydrochloride is a quinazolinone alkaloid found in the roots and leaves of Dichroa febrifuga, with antimalarial activity .
|
-
- HY-N0675
-
|
Others
|
Cancer
|
Anhydrovinblastine is a monoterpenoid indole alkaloid that can be isolated from Catharanthus roseus leaves .
|
-
- HY-117526
-
-
- HY-N3721
-
|
Others
|
Others
|
Demethylcephalotaxinone is an alkaloid. Demethylcephalotaxinone can be isolated from Hainan cycad (C. hainanensis) .
|
-
- HY-N3195
-
|
Others
|
Others
|
Neotuberostemonone is an alkaloid, that can be isolated from the roots of Stemona mairei (levl.) Krause .
|
-
- HY-W783671
-
Tribulusterine
|
Others
|
Others
|
Perlolyrin (Tribulusterine) is an alkaloid that can be isolated from dried fruits of Tribulus terrestris .
|
-
- HY-N3198A
-
(-)-Sophoramine
|
Others
|
Others
|
Sophoramine ((-)-Sophoramine), an alkaloid, is a dehydro-derivative of Matrine .
|
-
- HY-N9504
-
-
- HY-W705106
-
(-)-(S)-Coclaurine hydrochloride; (S)-Coclaurine hydrochloride; l-Coclaurine hydrochloride
|
nAChR
|
Neurological Disease
|
(-)-Coclaurine hydrochloride (compound I) is a class of tetrahydroisoquinoline alkaloids that can be isolated from Sarcopetalum harveyanum. (-)-Coclaurine hydrochloride is a nicotinic acetylcholine receptor (nAChRs) antagonist .
|
-
- HY-N0675A
-
|
Others
|
Cancer
|
Anhydrovinblastine sulfate is a monoterpenoid indole alkaloid that can be isolated from Catharanthus roseus leaves .
|
-
- HY-N10376
-
19-Hydroxytubotaiwine
|
Others
|
Infection
Cancer
|
Lagunamine (19-Hydroxytubotaiwine) is an alkaloid that isolated from the leaves of Philippine Alstonia scholaris. .
|
-
- HY-N11131
-
|
Others
|
Others
|
9-O-Methylstecepharine (compound 7) is an alkaloid that can be found in Stephania cepharantha .
|
-
- HY-N1088
-
Demethoxyvindoline
|
Others
|
Cardiovascular Disease
|
Vindorosine is an alkaloid from Catharanthus trichophyllus Roots. Vindorosine relaxes renal arteries .
|
-
- HY-N12252
-
|
Others
|
Others
|
N-Acetylcytisine is a kind of alkaloid. N-Acetylcytisine can be isolated from T. maderensis .
|
-
- HY-N3047
-
O-Methylpiperolactam B; Piperolactam B methyl ether
|
Others
|
Cardiovascular Disease
|
Piperolactam C (O-Methylpiperolactam B) is a natural alkaloid with anti-platelet aggregation effects .
|
-
- HY-116590
-
|
Others
|
Neurological Disease
|
(±)-Glaziovine, a proaporphine alkaloid, has anxiolytic activity. (±)-Glaziovine can be used for neuropharmacological research .
|
-
- HY-127011
-
-
- HY-N12576
-
|
Others
|
Others
|
Koumidine is an alkaloid that can be isolated from Gelsemium elegans .
|
-
- HY-N7767
-
-
- HY-B1181
-
|
Others
|
Cardiovascular Disease
|
Hydrastinine hydrochloride is a major alkaloid constituent in goldenseal (Hydrastis canadensis). Hydrastinine hydrochloride can be used as a haemostatic agent .
|
-
- HY-B1181A
-
|
Others
|
Cardiovascular Disease
|
Hydrastinine is a major alkaloid constituent in goldenseal (Hydrastis canadensis). Hydrastinine can be used as a haemostatic agent .
|
-
- HY-123077
-
|
Fungal
|
Infection
|
Norsanguinarine, an alkaloid, has antifungal activity against Alternaria brassicicola, Curvularia maculans at 1000 ppm .
|
-
- HY-N1629
-
|
Others
|
Others
|
1-Hydroxycanthin-6-one is an alkaloid that can be found in Ailanthus giraldii .
|
-
- HY-N2637
-
|
Others
|
Others
|
Yibeinoside A is an alkaloid isolated from the bulb of Fritillaria pallidiflora Schreb .
|
-
- HY-119731
-
|
p38 MAPK
NF-κB
|
Others
|
Antidesmone is a isoquinoline alkaloid that can be isolated from Antidesma membranaceum .
|
-
- HY-122931
-
|
Others
|
Others
|
Supinine is an alkaloid. Supinine can be isolated from Heliotropium europaeum .
|
-
- HY-W012185A
-
-
- HY-N3398
-
-
- HY-N3098
-
|
Others
|
Others
|
Pelirine is an alkaloid isolated from R. perakensis and causes death in mice at concentrations of 100 mg/kg and above .
|
-
- HY-N8452
-
|
Others
|
Others
|
Noroxyhydrastinine (compound 1) is an alkaloid. Noroxyhydrastinine can be isolated from the ethanolic extract of the roots of Thalictrum angustifolium .
|
-
- HY-N3186
-
|
Others
|
Others
|
N-Methoxyanhydrovobasinediol is an alkaloid that can be isolated from Gelsemium elegans. N-Methoxyanhydrovobasinediol can be used as a reference .
|
-
- HY-119215
-
|
Others
|
Cardiovascular Disease
|
Antioquine is a bisbenzyltetrahydroisoquinoline alkaloid that can beisolated from Pseudoxandra scleroderma. Antioquine inhibits KCl-induced contraction .
|
-
- HY-N10209
-
-
- HY-N2352
-
-
- HY-N8548
-
-
- HY-N7470
-
|
Others
|
Others
|
Daphnicyclidin F is a Daphniphyllum alkaloid isolated from the stem of Daphniphyllum humile .
|
-
- HY-169743
-
|
Others
|
Others
|
Pegamine is a quinazoline-quinoline alkaloid that can be isolated from Peganum nigellastrum .
|
-
- HY-A0220
-
-
- HY-N2616R
-
|
Others
|
Metabolic Disease
|
Vomicine (Standard) is the analytical standard of Vomicine. This product is intended for research and analytical applications. Vomicine, an alkaloid, shows antidiabetic activity .
|
-
- HY-117034
-
|
Others
|
Others
|
Rankinidine is an oxindole alkaloid that is isolated from the MeOH extract of the stem of Gelsemium rankinii .
|
-
- HY-N1021
-
|
Others
|
Others
|
11-Hydroxytabersonine is an alkaloid compound isolated from the roots of Melodinus henryi .
|
-
- HY-N9147
-
-
- HY-N9014
-
|
Others
|
Others
|
Bisdehydroneotuberostemonine (Compound 4) is a
kind of alkaloid. Bisdehydroneotuberostemonine is isolated from naturalStemona tuberosa .
|
-
- HY-N2561A
-
|
Others
|
Others
|
Spartioidine N-oxide is a pyrrolizidine alkaloid and can be isolated from Senecio vulgaris .
|
-
- HY-N1210
-
Spiramine C acetate (ester)
|
Bacterial
|
Cancer
|
Spiramine A (Spiramine C acetate (ester)) is a diterpene alkaloid with antitumor and antimicrobial activity. Spiramine A inhibits PAF-induced rabbit platelet aggregation in a concentration-dependent manner, with an IC50 vallue of 6.7 μM .
|
-
- HY-N1343
-
-
- HY-N2550
-
(+)-(R)-Coclaurine; (R)-Coclaurine; d-Coclaurine
|
Others
|
Neurological Disease
|
(+)-Coclaurine ((+)-(R)-Coclaurine), benzyltetrahydroisoquinoline alkaloid isolated from a variety of plant sources. (+)-Coclaurine has anti-aging activity .
|
-
- HY-N0924A
-
Tetrahydrocoptisine hydrochloride
|
Parasite
|
Inflammation/Immunology
|
(±)-Stylopine (Tetrahydrocoptisine) hydrochloride is an alkaloid compound originally isolated from Corydalis tubers that exhibits anti-inflammatory and anti-parasitic activities .
|
-
- HY-N0924
-
Tetrahydrocoptisine
|
Parasite
|
Inflammation/Immunology
|
(±)-Stylopine (Tetrahydrocoptisine) is an alkaloid compound originally isolated from Corydalis tubers that exhibits anti-inflammatory and anti-parasitic activities .
|
-
- HY-N2550A
-
(+)-(R)-Coclaurine hydrochloride; (R)-Coclaurine hydrochloride; d-Coclaurine hydrochloride
|
Others
|
Neurological Disease
|
(+)-Coclaurine ((+)-(R)-Coclaurine) hydrochloride, benzyltetrahydroisoquinoline alkaloid isolated from a variety of plant sources. (+)-Coclaurine hydrochloride has anti-aging activity .
|
-
- HY-N2697
-
|
Monoamine Oxidase
|
Neurological Disease
|
6-Acetonyl-N-methyldihydrodecarine is a natural alkaloid that can be isolated from roots of Zanthoxylum rigidum. An inhibitor of monoamine oxidases .
|
-
- HY-W707957
-
|
Drug Intermediate
|
Cancer
|
Intermedine N-oxide is a pyrrolizidine alkaloid indicine that can be found in Crotalaria spectabilis. Intermedine N-oxide shows anticancer activity .
|
-
- HY-168778
-
-
- HY-12535
-
-
- HY-N3122
-
|
Bacterial
|
Infection
|
Pachyaximine A, an alkaloid isolated from the root of Sarcococca hookeriana, has some antibacterial activity .
|
-
- HY-N3374
-
10-O-Methylsarpagine
|
Others
|
Others
|
Lochnerine is an indole alkaloid can be isolated from the stem bark extract of Alstonia macrophylla .
|
-
- HY-N9355
-
|
Others
|
Others
|
(+)-N-Formylnorglaucine is an aporphine alkaloid isolated from the leaves of Unonopsis stipitata. (+)-N-Formylnorglaucine contains a formyl group linked to the heterocyclic nitrogen .
|
-
- HY-131413
-
Sanguinine
|
Cholinesterase (ChE)
|
Neurological Disease
|
O-Desmethyl Galanthamine (Sanguinine) is galanthamine-type alkaloid. O-Desmethyl Galanthamine is an acetylcholinesterase (AChE) inhibitor, with an IC50 1.83 μM .
|
-
- HY-125429
-
|
Others
|
Cancer
|
Lokysterolamine B is a steroidal alkaloid which can be extracted from sponge genus Corticium. Lokysterolamine B can be utilized in cancer research .
|
-
- HY-N7771R
-
|
Others
|
Others
|
Spartioidine (Standard) is the analytical standard of Spartioidine. This product is intended for research and analytical applications. Spartioidine is an alkaloid that can be isolated from Senecio vulgaris .
|
-
- HY-N7265
-
|
Cholinesterase (ChE)
|
Neurological Disease
|
Epi-galantamine is a diastereomer of Galantamine. Epi-galantamine is an alkaloid isolated from the bulbs and flowers of Caucasian snowdrop (Galanthus woronowii). Epi-galantamine inhibits AChE with an EC50 of 45.7 μM .
|
-
- HY-N7596
-
|
Others
|
Cancer
|
Isoverticine, a bioactive isosteroidal alkaloid isolated from bulbus of Fritillaria pallidiflora, displays significant cytotoxicity .
|
-
- HY-N8315
-
-
- HY-N9356
-
|
Others
|
Others
|
Oxocrebanine, an aporphine alkaloid, can be found in Fissistigma poilanei (Annonaceae) .
|
-
- HY-N12063
-
|
Others
|
Others
|
Tetrahydropalmatrubine is an alkaloid that can be isolated from the herb of Corydalis saxicola .
|
-
- HY-N3397
-
Oxolaureline
|
Others
|
Others
|
Lauterine is an alkaloid that can be isolated from Laurelia novae-zelandiae .
|
-
- HY-N4173
-
|
Drug Metabolite
|
Metabolic Disease
|
8-Oxoepiberberine is an alkaloid metabolite in the plasma after oral administration of Zuojin formula, a traditional chinese medicine used to treat gastrointestinal disease .
|
-
- HY-N10682
-
|
Insecticide
|
Others
|
Hypoglaunine A is a sesquiterpene pyridine alkaloid isolated from the bark of the roots of Tripterygium hypoglaucum, a traditional Chinese medicine often used as a cancer and insecticide research .
|
-
- HY-N7183
-
|
NF-κB
|
Inflammation/Immunology
|
9-Hydroxycanthin-6-one is an alkaloid compound. 9,10-Dimethoxycanthin-6-one exhibits NF-κB inhibitory effects with an IC50 of 3.8 μM .
|
-
- HY-N0687
-
|
Microtubule/Tubulin
|
Cancer
|
Vindoline, a vinca alkaloid extracted from the leaves of Catharanthus roseus, weakly inhibits tubulin self-assembly .
|
-
- HY-N6050
-
-
- HY-B0628
-
|
Microtubule/Tubulin
|
Cancer
|
Vinflunine is a type of fluorinated vinca alkaloid that has the ability to block mitosis and interact with tubulin .
|
-
- HY-N1248
-
(+)-Scandine
|
Others
|
Others
|
Scandine is a alkaloid compound isolated from the twigs and leaves of Melodinus suaveolens .
|
-
- HY-122922
-
|
Others
|
Others
|
Valtropine is an alkaloid. Valtropine can be isolated from the leaves of Duboisia myoporoides .
|
-
- HY-N7182
-
|
NF-κB
|
Inflammation/Immunology
|
9,10-Dimethoxycanthin-6-one is an alkaloid compound. 9,10-Dimethoxycanthin-6-one exhibits NF-κB inhibitory effects with an IC50 of 19.5 μM .
|
-
- HY-N11436
-
|
Others
|
Others
|
Aconicarchamine B is a C20-diterpenoid alkaloid, which can be isolated from Aconitum carmichaelii .
|
-
- HY-136935
-
|
Adrenergic Receptor
|
Endocrinology
|
Alloyohimbine, an alkaloid, is a selective α2-adrenoceptor antagonist with K Dα1, K Dα2 of 0.28 μM and 0.006 μM, respectively .
|
-
- HY-124413
-
-
- HY-N12158
-
|
Apoptosis
|
Cancer
|
Pipermethystine is an alkaloid that can be isolated from the Kava plant. Pipermethystine decreases HepG2 cell cellular ATP levels, mitochondrial membrane potential, and induces apoptosis .
|
-
- HY-N12316
-
|
Others
|
Others
|
Goshuyuamide-I (compound 4) is a kind of alkaloid. Goshuyuamide-I can be isolated from the fruits of Euodia rutaecarpa. Goshuyuamide-I can be used in the research of analgesics .
|
-
- HY-N7341
-
|
Others
|
Others
|
8-Deacetylyunaconitine, a diterpenoid alkaloid, can be found in the root extract of A. forrestii .
|
-
- HY-107237
-
|
Others
|
Others
|
Broussonetine A is a pyrrolidine alkaloid compound isolated from the branches of Broussonetia kazinoki Sieb .
|
-
- HY-N3565
-
|
Others
|
Others
|
Cephalocyclidin A is a pentacyclic alkaloid and can be isolated from Cephalotaxus harringtonia var.nana .
|
-
- HY-N3288
-
|
Others
|
Others
|
Methylcarbazole-3-carboxylate is a carbazole alkaloid can be isolated from the peel of Clausena lansium (Lour.) Skeels .
|
-
- HY-N7370
-
|
Others
|
Others
|
Hybridaphniphylline B is a Daphniphyllum alkaloid and iridoid hybrid. Hybridaphniphylline B can be isolated from stems and leaves of Daphniphyllum longacemosum .
|
-
- HY-N0924B
-
(S)-Tetrahydrocoptisine
|
Others
|
Inflammation/Immunology
|
(-)-Stylopine ((S)-Tetrahydrocoptisine) is an enantiomer of Stylopine (HY-N0924). Stylopine is a major alkaloid component of the leaf of Chelidonium majus .
|
-
- HY-121748
-
|
Others
|
Others
|
Erycibelline is a naturally occurring dihydroxynortropane alkaloid. Erycibelline can be isolated from the Chinese herb medicine Erycibe elliptilimba Merr .
|
-
- HY-116786
-
|
Others
|
Cancer
|
11-Hydroxycanthin-6-one, a canthin-6-one alkaloid, is an antitumor agent which shows potent cytotoxic activity .
|
-
- HY-N12364
-
|
Others
|
Cancer
|
Bufoserotonin C is a new indole alkaloid from the traditional Chinese medicine Chansu that has antitumor activity, with IC 50 of 34.3 μM in A549 cells .
|
-
- HY-N6622
-
|
Others
|
Others
|
Tazettine is an alkaloid with low cytotoxicity to mammalian cell lines (CC50 >100 μg/mL) .
|
-
- HY-N2321
-
-
- HY-N1020
-
|
Others
|
Others
|
11-Hydroxyrankinidine is an alkaloid compound isolated from the whole plant of Gelsemium elegans .
|
-
- HY-N9511
-
|
Others
|
Others
|
Jacobine N-oxide, an N-oxide of Jacobine which is a pyrrolizidine alkaloid, can be found in Senecio hybrids that has thrips resistance .
|
-
- HY-N9005
-
|
Others
|
Cardiovascular Disease
|
Dysolenticin J has potent vasodilative effects on aortic rings. Dysolenticin J is an alkaloid that can be isolated from Dysoxylum lenticellatum .
|
-
- HY-12547
-
Achilleine
|
Bacterial
|
Infection
|
Betonicine (Achilleine), an alkaloid, has cell protectant activity. Betonicine protects Bacillus subtilis against extremes in osmolarity and growth temperatures .
|
-
- HY-N3217
-
|
Others
|
Others
|
N1-Methoxymethyl picrinine (compound 3) is an indole alkaloid that can be isolated from the leaves of Alstonia scholaris .
|
-
- HY-N7774
-
|
Others
|
Others
|
Echinatine N-oxide is a pyrrolizidine alkaloid found in R. graeca .
|
-
- HY-N11926
-
|
Others
|
Others
|
Ipalbine is a hexahydroindoliziae alkaloid that can be isolated from Ipomoea alba L .
|
-
- HY-133591
-
|
Bacterial
|
Infection
|
Senecivernine, a pyrrolizidine alkaloid isolated from Senecio species, exhibits a weakly mutagenic activity .
|
-
- HY-N1019
-
N-Methyl-11-hydroxyrankinidine
|
Others
|
Others
|
11-Hydroxyhumantenine is an alkaloid compound isolated from the EtOH extract of the stems of Gelsemium elegans .
|
-
- HY-N0901A
-
-
- HY-N11470
-
|
Others
|
Cancer
|
1,1′-Disinomenine is an alkaloid that can be isolated from the stems of Sinomenium acutum. 1,1′-Disinomenine shows weak inhibition against A549 and Hela cells .
|
-
- HY-114772
-
NSC 81464; Me reserpate
|
Others
|
Others
|
Methyl reserpate (NSC 81464) is a Yohimbine (HY-12715) type alkaloid, that can be isolated from Rauwolfia vomitoria roots and leaves .
|
-
- HY-N3547
-
Cassythine
|
Others
|
Cardiovascular Disease
|
Cassyfiline (Cassythine) is an aporphine alkaloid. Cassyfiline has potent vasorelaxing effects on precontracted rat aortic preparations with an IC50 of 0.09 μM .
|
-
- HY-149712
-
|
ICMT
|
Cancer
|
Spermatinamine is a novel alkaloid with a bromotyrosyl-spermine-bromotyrosyl sequence, and a natural ICMT inhibitor. Spermatinamine can be isolated from the Australian sponge Pseudoceratina .
|
-
- HY-122927
-
|
Others
|
Cancer
|
Symphytine is a pyrrolizidine alkaloid isolated from Symphytum officinale and has carcinogenicity .
|
-
- HY-N3526
-
|
Others
|
Others
|
Calyxamine B is a piperidine alkaloid that can be isolated from Calyx podatypa .
|
-
- HY-W015806
-
|
Endogenous Metabolite
|
Others
|
3-Pyridineacetic acid is a higher homologue of nicotinic acid, a breakdown product of nicotine (and other tobacco alkaloids) .
|
-
- HY-128683
-
|
Others
|
Others
|
Cycloposine is a steroidal alkaloid that can be found in the roots and rhizomes of Veratrum californicum. Cycloposine is also a teratogenic compound .
|
-
- HY-W004515
-
|
Endogenous Metabolite
|
Others
|
3-Pyridineacetic acid hydrochloride is a higher homologue of nicotinic acid, a breakdown product of nicotine (and other tobacco alkaloids) .
|
-
- HY-W066915
-
Nortropenol hydrochloride
|
Others
|
Others
|
Nortropine hydrochloride can be isolated from the Convolvulus subhirsutus alkaloid and is an intermediate in the decomposition and reaction of tropine to produce succinic acid .
|
-
- HY-N7594
-
O-Acetylsenecionine
|
Mitochondrial Metabolism
|
Others
|
Senecionine acetate (O-Acetylsenecionine) is a pyrrolizidine alkaloid. Senecionine acetate inhibits the sequestration of Ca 2+ in extramitochondrial and mitochondrial compartments possibly by inactivating free sulfhydryl groups .
|
-
- HY-124140
-
|
Cholinesterase (ChE)
|
Others
|
Heliosupine is a pyrrolizidine alkaloid. Heliosupine is an acetylcholinesterase (AChE) inhibitor, with an IC50 0.57 mM. Heliosupine exhibits deterrent effects against generalist herbivores .
|
-
- HY-W018601
-
Nortropenol
|
Drug Intermediate
|
Others
|
Nortropine (Nortropenol), isolated from the total alkaloids of Convolvulus subhirsutus, is an intermediate in tropine breakdown and reactions leading to succinate .
|
-
- HY-122772
-
|
Others
|
Inflammation/Immunology
|
(-)-Integerrimine, a pyrrolizidine alkaloid, has antiulcerogenic activity. (-)-Integerrimine is also a mutagenic and weakly clastogenic agent in Drosophila .
|
-
- HY-N7359
-
|
Others
|
Cancer
|
Securitinine is a Securinega alkaloid. Securitinine can be derived from the wood of Japanese medicinal plant Securinega suffruticosa var .
|
-
- HY-N3511
-
|
HIV
|
Infection
|
Triptonine B, a sesquiterpene pyridine alkaloid, inhibits HIV replication in H9 lymphocytes with an EC50 value of <0.10 μg/mL .
|
-
- HY-N1018
-
|
Others
|
Others
|
11-Hydroxygelsenicine is a 11-hydroxy-substituted gelsedine-type indole alkaloid compound isolated from the EtOH extract of the stems of Gelsemium elegans .
|
-
- HY-N2926
-
|
Parasite
|
Infection
|
β-Carboline-1-propionic acid is a alkaloid which can be extracted from Ailanthus altissima. β-Carboline-1-propionic acid can be used as an antileishmanial agent .
|
-
- HY-N1830
-
|
Others
|
Cancer
|
3-Epiwilsonine is an alkaloid from Cephalotaxus wilsoniana, exhibits effect on acute and chronic myeloid leukemia and malignant lymphoma .
|
-
- HY-113845
-
|
Others
|
Neurological Disease
|
(+)-Intermedine, a pyrrolizidine alkaloid (PA), exhibits significant cytotoxicity in neural progenitor cells (NPCs) .
|
-
- HY-N1948
-
|
Others
|
Others
|
Mitoridine is an indole alkaloid compound isolated from the stem bark of Rauwolfia cumminsii Stapf .
|
-
- HY-N1945
-
|
Others
|
Others
|
Bonvalotidine A is a lycoctonine-type C19-diterpenoid alkaloid isolated from the roots of Delphinium bonvalotii Franch .
|
-
- HY-122916
-
-
- HY-N3279
-
|
Others
|
Others
|
Methyl N1-demethoxycarbonylchanofruticosinate is an alkaloid isolated from the leaves of Kopsia flavida Blume of the Apocynaceae family .
|
-
- HY-N9537
-
|
Others
|
Inflammation/Immunology
|
Napelline is an alkaloid extracted from Baikal aconite (Aconitum baikalensis). Napelline can be used for the research of inflammation, antiexudative and analgesic .
|
-
- HY-N8723
-
|
Others
|
Neurological Disease
|
(1′S,2′S)-Nicotine-1'-oxide is an alkaloid N-oxide from the leaves, stems and roots of Nicotiana tabacum .
|
-
- HY-N10367
-
|
Topoisomerase
|
Cancer
|
Corydamine, 3-arylisoquinoline alkaloid, is a potent DNA topoisomerase I/II inhibitor. Corydamine has anti-cancer activity .
|
-
- HY-116490
-
|
mAChR
|
Cardiovascular Disease
|
Guvacoline hydrobromide, a pyridine alkaloid found in Areca triandra, can act as a weak full agonist of atrial and ileal mAChR .
|
-
- HY-65008
-
|
Others
|
Others
|
N-Demethylricinine is a ricinine, can be interconverted with ricinine in senescent and green castor plant leaves. Ricinine, is a α-pyridone alkaloid biosynthetically related to the pyridine nucleotide cycle. The alkaloid catabolism of ricinine is associated with aging process .
|
-
- HY-N12040
-
Iso-γ-fagarine
|
Others
|
Inflammation/Immunology
|
γ-Isofagarine (Iso-γ-fagarine) is an alkaloid that can be isolated from the root bark of Dictamnus angustifolius. Dictamnus angustifolius has been used in the research of rheumatism, bleeding, itching, jaundice, chronic hepatitis, skin diseases, etc .
|
-
- HY-134006
-
-
- HY-124261
-
|
Apoptosis
|
Cancer
|
Sampangine is an alkaloid that induces apoptosis by inducing cell cycle arrest in the G0/G1 phase. Sampangine can inhibit the biosynthesis of heme .
|
-
- HY-119642
-
|
Others
|
Others
|
Kopsinine is an indole alkaloid extracted from periwinkle flowers .
|
-
- HY-124503
-
|
Trk Receptor
|
Neurological Disease
|
Longanlactone is a natural pyrrole-lactone alkaloid that can be used as a neurotrophic agent. Longanlactone increases BDNF gene expression in neuro2a cells .
|
-
- HY-N10960
-
|
Others
|
Others
|
Stellarine C is a β-carboline alkaloid that can be isolated from Stellaria dichotoma var. lanceolata .
|
-
- HY-107811A
-
|
Monoamine Oxidase
|
Others
|
Harmol hydrochloride categorized as a β-carboline alkaloid. Harmol hydrochloride is a potent MAO inhibitor .
|
-
- HY-N0471
-
Hyoscyamine
|
mAChR
|
Neurological Disease
|
L-Hyoscyamine (Daturine), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine is a levo-isomer to Atropine (HY-B1205) .
|
-
- HY-N6078
-
|
Bacterial
|
Infection
|
Thalrugosaminine is a benzylisoquinoline alkaloid isolated from the roots of Thalictrum minus. Thalrugosaminine shows good antibacterial activity with MIC values of 64-128 µg/ml .
|
-
- HY-N8956
-
|
Others
|
Others
|
Pachysamine M (Compound 5) is a pregnane alkaloid.
Pachysamine M is isolated from naturalPachysandra terminalisSieb. et Zucc .
|
-
- HY-N2544
-
-
- HY-N0471C
-
Daturine sulfate hydrate
|
mAChR
|
Neurological Disease
|
L-Hyoscyamine sulfate hydrate, a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine sulfate hydrate is a levo-isomer to Atropine (HY-B1205) .
|
-
- HY-N2561AR
-
|
Others
|
Others
|
Spartioidine N-oxide (Standard) is the analytical standard of Spartioidine N-oxide. This product is intended for research and analytical applications. Spartioidine N-oxide is a pyrrolizidine alkaloid and can be isolated from Senecio vulgaris .
|
-
- HY-N3618
-
12,13-Dimethoxycoronaridine
|
Others
|
Cardiovascular Disease
Neurological Disease
|
Conopharyngine (12,13-Dimethoxycoronaridine) is the indole-alkaloid that can be isolated from Tabernaemontana pachysiphon. Conopharyngine affects the functions of cardiovascular and smooth muscle, and exhibits analgesic and nervous system stimulating activity .
|
-
- HY-N11491
-
|
Others
|
Others
|
8-Demethoxycephatonine is an isoquinoline alkaloid, that can be isolated from Sinomenium acutum (Menispermaceae) .
|
-
- HY-N9161
-
|
Others
|
Cancer
|
Echitoveniline, a monoterpenoid indole alkaloid, can be isolated from Alstonia mairei. Echitoveniline has no significant cytotoxicity against cancer cells (IC50: > 40 μM) .
|
-
- HY-122957
-
|
Cholinesterase (ChE)
|
Neurological Disease
|
Huperzine C is an alkaloid isolated from Huperzia serrate. Huperzine C is an acetylcholinesterase (AChE) inhibotor, with an IC50 of 0.6 μM. Huperzine C can be used for the research of Alzheimer’s disease .
|
-
- HY-N6931
-
|
Bacterial
|
Infection
|
Usaramine is a pyrrolizidine alkaloid isolated from seeds of Crolatalaria pallida. Usaramine demonstrates a highlighted antibiofilm activity against Staphylococcus epidermidis by reducing more than 50% of biofilm formation without killing the bacteria .
|
-
- HY-N10256
-
|
Endogenous Metabolite
|
Infection
|
Varioxepine A is a 3H-oxepine-containing alkaloid with a new oxa-cage found in the marine algal-derived endophytic fungus Paecilomyces variotii. Varioxepine A inhibits plant pathogenic fungus Fusarium graminearum .
|
-
- HY-N1163
-
-
- HY-124058
-
|
Insecticide
|
Others
|
Jacobine?is a pyrrolizidine alkaloid (PA) from Senecio jacobaea . Jacobine is active against second instar larvae of thrips .
|
-
- HY-111523
-
-
- HY-N8530
-
|
Others
|
Inflammation/Immunology
|
Conodurine is a monoterpenoid indole alkaloid.
Conodurine can inhibit lysosomal acidification. Conodurineis isolated from the natural
Tabernaemontana corymbosa .
|
-
- HY-N0050
-
(+)-Allomatrine
|
Others
|
Neurological Disease
|
Allomatrine ((+)-Allomatrine) is an alkaloid from the bark of Sophora japonica. Allomatrine has antinociceptive properties mediated mainly through the activation ofκ-opioid receptors .
|
-
- HY-W018758
-
|
Others
|
Others
Metabolic Disease
|
1-Phenylpropane-1,2-dione, isolated from young Ephedra sinica Stapf (Ephedraceae), is biosynthetic precursors of the ephedrine alkaloids .
|
-
- HY-126804
-
|
Antibiotic
|
Infection
Cancer
|
Safracin B, a tetrahydroisoquinoline (THIQ) alkaloid, is a naturally occurring antibiotic from Pseudomonas fluorescens. Safracin B exhibits broad spectrum antimicrobial and strong antitumor activities .
|
-
- HY-N3506
-
|
HIV
|
Infection
Inflammation/Immunology
Cancer
|
Wilfortrine is a bioactive sesquiterpene alkaloid. Wilfortrine exhibits immunosuppresive effects. Wilfortrine also can inhibit leukaemia cell growth in mice and shows anti-HIV activity .
|
-
- HY-N9407
-
|
GABA Receptor
|
Others
|
Guvacine ethyl ester (3.1b) is an alkaloid that can be found in betel nut. Guvacine ethyl ester can be used in the synthesis of GABA uptake inhibitor .
|
-
- HY-N0117A
-
(Z)-Couroupitine B; (Z)-Indigo red; (Z)-Indigopurpurin
|
Apoptosis
|
Cancer
|
(Z)-Indirubin is an isomer of Indirubin (HY-N0117). Indirubin is a bis-indole alkaloid and has emarkable anticancer activity against chronic myelocytic leukemia .
|
-
- HY-168365
-
|
Drug Isomer
|
Neurological Disease
|
(±)-Pellotine hydrochloride (Compound 2) is an alkaloid, which is found in L. diffusa and L. fricii. (±)-Pellotine hydrochloride decreases locomotor activity and the amount of rapid eye movement (REM) sleep in mice .
|
-
- HY-N0471A
-
Daturine sulfate
|
mAChR
|
Neurological Disease
|
L-Hyoscyamine sulfate (Daturine sulfate), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine sulfate is a levo-isomer to Atropine (HY-B1205) .
|
-
- HY-N8498
-
|
Apoptosis
|
Cancer
|
GKK1032B is an alkaloid compound that can be found in endophytic fungus Penicillium sp. GKK1032B can induce the apoptosis of human osteosarcoma MG63 cells through caspase pathway activation .
|
-
- HY-N1102
-
6-Hydroxypeganine
|
Angiotensin-converting Enzyme (ACE)
|
Cardiovascular Disease
|
Vasicinol is a reversible inhibitor of sucrase (IC50: 250 μM). Vasicinol is a HbF inducer. Vasicinol also inhibits Angiotensin-converting Enzyme (ACE). Vasicinol is apyrroquinazoline alkaloid that can be isolated from Adhatoda vasica .
|
-
- HY-118726
-
|
Topoisomerase
|
Cancer
|
Luotonin F is an alkaloid found in the aerial parts of the P. nigellastrum Bunge. Luotonin F shows cytotoxic activity against mouse leukemia P-388 cells by inhibiting human topoisomerase II .
|
-
- HY-N5009
-
|
Bacterial
|
Infection
|
Thermopsine is a quinolizidine alkaloid isolated from the fruits and pods and stem bark of Sophora velutina subsp. Thermopsine has antibacterial activity .
|
-
- HY-135743
-
cis-Apovincamine; (+)-Apovincamine
|
Tyrosinase
|
Cancer
|
Apovincamine (cis-Apovincamine) is an indole alkaloid isolated from the Malaysian Alstonia pneumatophora (Apocynaceae). Apovincamine shows anti-melanogenesis activity .
|
-
- HY-N10955
-
|
Others
|
Inflammation/Immunology
|
Dichotomine H is a P-carboline alkaloid that can be extracted from Stellaria dichotoma L. Dichotomine H has good antiallergic activity .
|
-
- HY-N2932
-
Amsonin; Amsonine; NSC 93133
|
Parasite
|
Infection
|
β-Yohimbine (Amsonin) is an indole alkaloid that can be isolated from Aspidosperma ulei Markgr. β-Yohimbine shows antiplasmodial activity against the Chloroquine (HY-17589A)-resistant Fc M29-Cameroon strain (IC50: > 1 μg/mL) .
|
-
- HY-N0901AR
-
|
Autophagy
Beclin1
α-synuclein
|
Neurological Disease
Cancer
|
Corynoxine B (Standard) is the analytical standard of Corynoxine B. This product is intended for research and analytical applications. Corynoxine B is a natural alkaloid and autophagy inducer that can improve Mn induced cellular autophagy dysregulation and enhance clearance of alpha synuclein (alpha syn) in Parkinson's disease mice .
|
-
- HY-N12423
-
|
Cholinesterase (ChE)
|
Neurological Disease
|
Bis-(-)-8-demethylmaritidine, a natural alkaloid, is a potent acetylcholinesterase (AChE) inhibitor. Bis-(-)-8-demethylmaritidine can be used for Alzheimer's disease research .
|
-
- HY-124412S
-
-
- HY-N12625A
-
|
CDK
|
Cancer
|
(S)-(-)-O-Demethylbuchenavianine (Compound (S)-(−)-1) is a flavonoidal alkaloids. (S)-(-)-O-Demethylbuchenavianine is a potent CDK inhibitor, with IC50 values of 0.03 and 0.05 μM for CDK1 and CDK5, respectively .
|
-
- HY-129477
-
|
HSV
|
Infection
|
Strictamine (compound 2) is an alkaloid with antiviral activity. Strictamine has significant inhibitory activity against herpes simplex virus (HSV) and adenovirus (ADV), with EC50 values ??of 0.36 μg/mL and 0.28 μg/mL, respectively .
|
-
- HY-N10283
-
|
Endogenous Metabolite
|
Neurological Disease
|
Neoechinulin C, an echinulin-related indolediketopiperazine alkaloid, protects the neuronal cells against paraquat-induced damage in a Parkinson’s disease model .
|
-
- HY-N2700
-
|
Others
|
Cancer
|
6a-Hydroxymedicarpin is a monoterpenoid indole alkaloid that can be isolated from Ochrosia elliptica. 6a-Hydroxymedicarpin has anticancer activity .
|
-
- HY-N15187
-
|
Parasite
|
Infection
|
Acronycidine is a quinoline alkaloid with antimalarial activity and can be extracted from Acronychia baueri Schott. Acronycidine can be utilized in malari research .
|
-
- HY-N3918
-
|
HCV
|
Infection
|
γ-Fagarine is a furoquinoline alkaloid naturally occurring in Rutae Herba. γ-Fagarine has strong anti-HCV activities with IC50 of 20.4 μg/mL and is also a sister chromatid exchanges (SCEs) inducer .
|
-
- HY-124140R
-
|
Cholinesterase (ChE)
|
Others
|
Heliosupine (Standard) is the analytical standard of Heliosupine. This product is intended for research and analytical applications. Heliosupine is a pyrrolizidine alkaloid. Heliosupine is an acetylcholinesterase (AChE) inhibitor, with an IC50 0.57 mM. Heliosupine exhibits deterrent effects against generalist herbivores .
|
-
- HY-N13715
-
-
- HY-121162
-
(+)-Mesembrine
|
5-HT Receptor
Phosphodiesterase (PDE)
|
Neurological Disease
|
Mesembrine ((+)-Mesembrine) a main alkaloid that features an aryloctahydroindole skeleton. Mesembrine is a 5-HT transporter inhibitor with a Ki of 1.4 nM. Mesembrine also inhibits phosphodiesterase 4B (PDE4B) with an IC50 of 7.8 μM .
|
-
- HY-N4157
-
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mAChR
5-HT Receptor
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Neurological Disease
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Isopteropodine is heteroyohimbine-type oxindole alkaloid components of Uncaria tomentosa (Willd.) DC. Isopteropodine acts as positive modulators of muscarinic M1 and 5-HT2 receptors .
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- HY-116436
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Sodium Channel
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Neurological Disease
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Clathrodin is a marine alkaloid that can be isolated from sponges of the genus, Agelas. Clathrodin is a modulator of voltage-gated sodium (NaV) channels. Clathrodin is a sodium channel neurotoxin influencing sodium channel ionic conductance .
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- HY-N2759
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Bacterial
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Infection
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7-O-Isopentenyl-γ-fagarine is an alkaloid that can be isolated from Peltostigma guatemalense. 7-O-Isopentenyl-γ-fagarine has antibacterial and antimalarial activities in vitro .
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- HY-121002
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- HY-N7600
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25-Epieduardine; Puqiedinone
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Others
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Others
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Zhebeirine (Puqiedinone), a steroidal alkaloid, is isolated from the bulbs of Fritillaria puqiensis. Zhebeirine exhibits antitussive and expectorant properties .
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- HY-122367
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Bacterial
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Neurological Disease
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Neoxaline is an alkaloid produced by Aspergillus japonicus. Neoxaline does not possess antimicrobial activities, but weakly stimulates the central nervous system .
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- HY-N10386
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- HY-W014928
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(S)-Anabasine hydrochloride; (+)-Anabasine hydrochloride
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nAChR
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Neurological Disease
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Anabasine ((S)-Anabasine) hydrochloride is an alkaloid that found as a minor component in tobacco (Nicotiana). Anabasine is a botanical pesticide nicotine, acts as a full agonist of nicotinic acetylcholine receptors (nAChRs). Anabasine induces depolarization of TE671 cells endogenously expressing human fetal muscle-type nAChRs (EC50=0.7 µM) .
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- HY-N9404
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Sodium Channel
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Neurological Disease
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6-Benzoylheteratisine is an Aconitum alkaloid with potential neuroprotective activity. 6-Benzoylheteratisine can antagonize tetrodotoxin, inhibit the increase of [Na +]i, [Ca 2+]i and glutamate release, and block sodium channels. 6-Benzoylheteratisine has an inhibitory effect on the neuronal activity underlying epileptiform burst discharge .
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- HY-N2074
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Lipoxygenase
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Inflammation/Immunology
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Picrinine, an akuammiline alkaloid, is isolated from the leaves of Alstonia scholaris. Picrinine exhibits anti-inflammatory activity through inhibition of the 5-lipoxygenase enzyme .
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- HY-N7153
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Others
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Cancer
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10-Hydroxycanthin-6-one is an antileukemic canthin-6-one alkaloid from Brucea antidysenterica. Antitumor agent .
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- HY-N6637
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Others
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Cancer
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Senecionine n-oxide is the primary product of pyrrolizidine alkaloid biosynthesis in root cultures of Senecio vulgaris. Senecionine N-oxide has anti-cancer activity .
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- HY-W001909
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nAChR
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Metabolic Disease
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Myosmine, a specific tobacco alkaloid in nuts and nut products, has low affinity for a4b2 nicotinic acetylcholinergic receptors (nAChR) with a Ki of 3300 nM .
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- HY-N2076
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(-)-Cephaeline hydrochloride; NSC 32944 monohydrochloride
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Flavivirus
Filovirus
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Infection
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Cephaeline hydrochloride ((-)-Cephaeline hydrochloride) is a phenolic alkaloid in Indian Ipecac roots. Cephaeline hydrochloride exhibits potent inhibition of both Zika virus (ZIKV) and Ebola virus (EBOV) infections .
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- HY-N6794
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(Z)-Hymenialdisine; Hymenialdisine
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AMPK
VEGFR
PDGFR
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Cancer
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10Z-Hymenialdisine ((Z)-Hymenialdisine) is a natural bioactive pyrrole alkaloid. 10Z-Hymenialdisine is a pan kinase inhibitor, and has anticancer activities .
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- HY-N11777
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NHAP
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NF-κB
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Cancer
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(−)-N-Hydroxyapiosporamide (NHAP), an alkaloid, is an NF-κB inhibitor with potent antitumor activity in vitro and in vivo. (−)-N-Hydroxyapiosporamide can be used for the research of colorectal cancer (CRC) .
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- HY-N8361
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HIV
Apoptosis
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Infection
Cancer
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Glycoborinine, a natural carbazole alkaloid, can be isolated from Glycosmis pentaphylla. Glycoborinine induces HepG2 cell apoptosis through mitochondrial pathway. Glycoborinine also inhibits HIV replication in cells .
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- HY-125559
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Drug Metabolite
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Cardiovascular Disease
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Jesaconitine is a toxic alkaloid. Jesaconitine can be derived from Aconitum. Jesaconitine is one of the major metabolites that can be detected in the blood of the right atrium after aconitum poisoning. Various types of arrhythimia are characteristic in aconitine intoxication .
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- HY-131300
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Parasite
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Infection
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Colchicoside is a bioactive tropolone alkaloid with anti-leishmanial and anti-leishmanial?activities .
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- HY-N6638
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Others
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Metabolic Disease
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Retrorsine is a naturally occurring toxic pyrrolizidine alkaloid. Retrorsine can bind with DNA and inhibits the proliferative capacity of hepatocytes. Retrorsine can be used for the research of hepatocellular injury .
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- HY-N3072
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Opioid Receptor
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Neurological Disease
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Picraline is a natural alkaloid that targets opioid receptors with binding affinities with Ki values of 132 μM, 2.38 μM and 98.8 μM for μOR, κOR and δOR, respectively .
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- HY-113845R
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Others
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Neurological Disease
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(+)-Intermedine (Standard) is the analytical standard of (+)-Intermedine. This product is intended for research and analytical applications. (+)-Intermedine, a pyrrolizidine alkaloid (PA), exhibits significant cytotoxicity in neural progenitor cells (NPCs) .
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- HY-W004515R
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Endogenous Metabolite
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Others
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3-Pyridylacetic acid (hydrochloride) (Standard) is the analytical standard of 3-Pyridylacetic acid (hydrochloride). This product is intended for research and analytical applications. 3-Pyridineacetic acid hydrochloride is a higher homologue of nicotinic acid, a breakdown product of nicotine (and other tobacco alkaloids) .
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- HY-N0132A
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- HY-N0132
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- HY-W705415A
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Drug Intermediate
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Infection
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(S)-N-methylcoclaurine is a substrate of CyNMCH. (S)-N-methylcoclaurine serves as an important branch point intermediate in benzylisoquinoline alkaloid biosynthesis.
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- HY-N0471R
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mAChR
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Neurological Disease
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L-Hyoscyamine (Standard) is the analytical standard of L-Hyoscyamine. This product is intended for research and analytical applications. L-Hyoscyamine (Daturine), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine is a levo-isomer to Atropine (HY-B1205) .
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- HY-N6931R
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Bacterial
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Infection
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Usaramine (Standard) is the analytical standard of Usaramine. This product is intended for research and analytical applications. Usaramine is a pyrrolizidine alkaloid isolated from seeds of Crolatalaria pallida. Usaramine demonstrates a highlighted antibiofilm activity against Staphylococcus epidermidis by reducing more than 50% of biofilm formation without killing the bacteria .
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- HY-N10681
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Euonine
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Others
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Others
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Evonimine (Euonine) is an alkaloid isolated from Tripterygium wilfordii Hook. Evonimine exhibits significant inhibition of humoral-mediated immunity using the haemolytic response as an indicator, and shows good anti-feeding activity against the lepidopteran Spodoptera littoralis .
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- HY-N3197
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(+)-Neostenine
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P-glycoprotein
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Cancer
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Neostenine is a stenine-type Stemona alkaloid, with antitussive activity. Neostenine is also a substrate of P-glycoprotein with high absorptive permeability in Caco-2 monolayer model. Neostenine also shows oral activity for intestinal application .
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- HY-N4156
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Others
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Others
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Pteropodine (compound 3) is a monoterpenoid oxindole alkaloid that can be isolated from Hamelia patens. Pteropodine modulates the functions of M1 muscarinic and 5-HT2 receptors. Pteropodine has antioxidant and antimutagenic properties .
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- HY-N10285
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Tyrosinase
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Infection
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Phaeosphaone D is a thiodiketopiperazine alkaloid compound isolated from Phaeosphaeria fuckelii, an endophytic fungus. Phaeosphaone D displays mushroom tyrosinase inhibitory activity with an IC50 value of 33.2 μM .
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- HY-132940
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Others
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Others
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(+)-Pileamartine A is a complex alkaloid. (+)-Pileamartine A can be accessed via intramolecular Pd(0)-catalyzed alkene 1,2-aminoarylation reactions .
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- HY-119529
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3,8-Quinolinediol
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Others
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Cancer
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Jineol is a cytotoxic alkaloid from the centipede Scolopendra subspinipes. Jineol exhibits modest cytotoxic activity in vitro against the growth of human tumor cell lines .
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- HY-137305
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Others
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Others
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O-Acetylgalanthamine, a acetylated alkaloid, is a natural product that can be isolated from Narcissus pseudonarcissus .
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