Search Result
Results for "
Alpha 1 proteinase Inhibitors
" in MedChemExpress (MCE) Product Catalog:
6608
Inhibitors & Agonists
472
Biochemical Assay Reagents
538
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-P1912
-
|
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MMP
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Endocrinology
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Alpha 1(I) Collagen (614-639), human is a peptide fragment of alpha-1 type I collagen.
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-
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- HY-132604A
-
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ARO-AAT sodium
|
Small Interfering RNA (siRNA)
|
Metabolic Disease
|
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Fazirsiran sodium is a second-generation RNAi agent. Fazirsiran sodium consistes of a cholesterol-conjugated RNAi trigger (chol-RNAi) to selectively degrade Alpha1-antitrypsin (AAT) mRNA by RNAi and a melittin-derived peptide conjugated to N-acetylgalactosamine (NAG) formulated as the excipient EX1 to promote endosomal escape of the chol-RNAi in hepatocytes [1]. Fazirsiran sodium can be used in the study of Alpha-1 Antitrypsin Deficiency (AATD) liver disease.
|
-
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- HY-108717
-
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Protease K
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Ser/Thr Protease
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Others
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Proteinase K (Protease K) is a nonspecific serine protease that is useful for general digestion of proteins. Proteinase K is active in the presence of SDS or urea and over a wide range of pH (4-12), salt concentrations, and temperatures. Proteinase K can be use for promoting methods of viral nucleic acid extraction, and detection [1] .
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-
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- HY-E70064
-
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Endogenous Metabolite
|
Others
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alpha-1,3-Fucosyltransferase (α1,3FucT) catalyzes the transfer of L-fucose moiety from guanosine diphosphate-beta-L-fucose (GDP-Fuc) to acceptor sugars. alpha-1,3-Fucosyltransferase (α1,3FucT) is often used in biochemical studies, and it can be used to form fucoglycoconjugates [1].
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-
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- HY-P2978
-
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Ser/Thr Protease
|
Neurological Disease
|
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Alpha 1 Antichymotrypsin, Human Plasma is a serine protease inhibitor. Alpha 1 Antichymotrypsin, Human Plasma appears in the amyloid lesions of Alzheimer's disease. Alpha 1 Antichymotrypsin, Human Plasma can be used in Alzheimer's disease research [1].
|
-
-
- HY-106416
-
-
-
- HY-E70380
-
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ArcticZymes proteinase
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Biochemical Assay Reagents
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Others
|
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Endopeptidase, arctic marine microbial (ArcticZymes Proteinase), a proteinase, is used for the digestion of chromatin, thus releasing naked DNA. As it is thermolable, it can be inactivated at temperatures compatible with RNA integrity and DNA as double strands [1].
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-
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- HY-132604
-
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ARO-AAT
|
Small Interfering RNA (siRNA)
|
Metabolic Disease
|
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Fazirsiran (ARO-AAT) is a second-generation RNAi agent. Fazirsiran consistes of a cholesterol-conjugated RNAi trigger (chol-RNAi) to selectively degrade Alpha1-antitrypsin (AAT) mRNA by RNAi and a melittin-derived peptide conjugated to N-acetylgalactosamine (NAG) formulated as the excipient EX1 to promote endosomal escape of the chol-RNAi in hepatocytes [1]. Fazirsiran can be used in the study of Alpha-1 Antitrypsin Deficiency (AATD) liver disease.
|
-
-
- HY-101345
-
-
-
- HY-E70059
-
|
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Glucosylceramide Synthase (GCS)
|
Cancer
|
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alpha-1,2-Fucosyltransferase (α1,2FucT), i.e., alpha 1, 2-fucosyltransferase, is often used in biochemical studies. alpha-1,2-Fucosyltransferase is a rate-limiting enzyme, can catalyze the synthesis of Lewis y (a cell membrane-associated carbohydrate antigen) [1].
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-
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- HY-W014726
-
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(±)-Phenylephrine hydrochloride
|
Adrenergic Receptor
|
Cardiovascular Disease
|
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DL-Phenylephrine ((±)-Phenylephrine) hydrochloride is a selective agonist of the alpha1-adrenergic receptor, exhibiting potent vasoconstrictive activity.
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-
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- HY-E70004
-
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Biochemical Assay Reagents
|
Others
|
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Microbial neutral proteinase is a neutral proteinase from microorganisms and is useful for cell isolation and tissue dissociation [1].
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-
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- HY-19371
-
|
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GABA Receptor
|
Neurological Disease
|
|
Lorediplon is a novel non-benzodiazepine drug acting as a GABAA receptor modulator, differentially active at the alpha1-subunit, associated with promoting sleep.
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-
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- HY-E70053
-
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Alpha 1,3GT
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Endogenous Metabolite
|
Metabolic Disease
|
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alpha-1,3-Galactosyltransferase (GTB) (alpha 1,3GT) catalyzes the synthesis of the xenoantigen or α-galactose (α-Gal) epitope. alpha-1,3-Galactosyltransferase (GTB) transfers galactose from UDP-Gal to type 1 or type 2, αFuc1→2βGal-R (H)-terminating acceptors [1].
|
-
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- HY-100740C
-
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(1α,1'S,4β)-AZD3293; (1α,1'S,4β)-LY3314814
|
Beta-secretase
|
Neurological Disease
|
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(1α,1'S,4β)-Lanabecestat ((1α,1'S,4β)-AZD3293) a less active enantiomer of Lanabecestat. Lanabecestat is a potent, orally active and blood-brain barrier penetrating BACE1 inhibitor with a Ki of 0.4 nM [1].
|
-
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- HY-19279A
-
|
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Adrenergic Receptor
|
Endocrinology
|
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JTH-601 Free base is a novel alpha1-adrenoceptor antagonist that exhibits potent activity in inhibiting phenylephrine-induced contractions in lower urinary tract tissues. JTH-601 Free base competitively antagonizes alpha1-adrenoceptor-mediated contractile responses, demonstrating greater potency than prazosin or tamsulosin. JTH-601 Free base is anticipated to be effective in treating urinary outlet obstruction associated with benign prostatic hyperplasia.
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- HY-P2871B
-
|
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Endogenous Metabolite
|
Metabolic Disease
|
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α1-3,4,6 Galactosidase is a broad specificity exoglycosidase that catalyzes the hydrolysis of terminal, non-reducing α1-3, α1-4 and α1-6-linked galactose residues from oligosaccharides [1].
|
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- HY-147100
-
|
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PROTACs
Adrenergic Receptor
|
Cancer
|
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α1A-AR Degrader 9c (compound 9c) is a potent, selective and reversible α1A-AR (Adrenergic receptor) PROTAC degrader, with a DC50 of 2.86 μM. α1A-AR Degrader 9c induces α1A-AR degradation can be attributed to proteasomal degradation. α1A-AR Degrader 9c inhibits the proliferation of PC-3 cells, with an IC50 of 6.12 μM. α1A-AR Degrader 9c shows antitumor activity, and can be used for prostate cancer research [1].
|
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- HY-118335
-
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SZL 49
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Adrenergic Receptor
|
Cardiovascular Disease
|
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Prazobind (SZL 49), a prazosin analog, is a selective α1-adrenoceptor antagonist. Prazobind competes for alpha 1-adrenoceptor binding sites with a similar potency (IC50 of 1 nM) in tissues enriched in both the alpha 1A (hippocampus) and alpha 1B (liver) subtypes. Prazobind can be used for the study of blood pressure [1] .
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- HY-P4976
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-
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- HY-P3150
-
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Ser/Thr Protease
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Others
|
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Recombinant Proteinase K is a serine protease that cleaves the carboxy-terminated peptide bonds of aliphatic and aromatic amino acids. Recombinant Proteinase K can be used to digest proteins and remove contamination from nucleic acid preparations [1].
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- HY-139697
-
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Others
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Infection
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HAV 3C proteinase-IN-1 is a inhibitor of Hepatitis A virus 3C proteinase.
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-
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- HY-105672
-
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Adrenergic Receptor
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Cancer
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Cafaminol (Methylcoffanolamine) is a vasoconstrictor and anticatarrhal that selectively binds to alpha-1 receptors, causing blood vessels to constrict. Cafaminol is an xanthine derivative which can be utilized in decongestant and antitumor research [1].
|
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- HY-B0391B
-
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KT-611 hydrochloride; BM-15275 hydrochloride
|
Adrenergic Receptor
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Cancer
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Naftopidil hydrochloride (KT-611 hydrochloride) is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes, respectively. Naftopidil hydrochloride has antiproliferative effects. Naftopidil hydrochloride can be used for the research of prostate hyperplasia [1].
|
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- HY-A0142A
-
|
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Adrenergic Receptor
|
Endocrinology
|
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Dapiprazole hydrochloride is a potent, selective and orally active alpha-1 adrenoceptor antagonist. Dapiprazole hydrochloride suppresses the opioid withdrawal symptoms. Dapiprazole hydrochloride is also used as eye drops for reversing mydriasis [1] .
|
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- HY-A0142
-
|
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Adrenergic Receptor
|
Endocrinology
|
|
Dapiprazole is a potent, selective and orally active alpha-1 adrenoceptor antagonist. Dapiprazole suppresses the opioid withdrawal symptoms. Dapiprazole is also used as eye drops for reversing mydriasis [1] .
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- HY-B0391A
-
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KT-611 dihydrochloride; BM-15275 dihydrochloride
|
Adrenergic Receptor
|
Cancer
|
|
Naftopidil dihydrochloride (KT-611 dihydrochloride) is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes, respectively. Naftopidil dihydrochloride has antiproliferative effects. Naftopidil dihydrochloride can be used for the research of prostate hyperplasia [1] .
|
-
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- HY-B0391
-
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KT-611; BM-15275
|
Adrenergic Receptor
|
Cardiovascular Disease
Endocrinology
|
|
Naftopidil (KT-611) is is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes, respectively. Naftopidil has antiproliferative effects. Naftopidil can be used for the research of prostate hyperplasia [1] .
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- HY-W471937
-
-
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- HY-17549
-
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CRL 40028
|
Adrenergic Receptor
|
Neurological Disease
Endocrinology
|
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Adrafinil (CRL-40028, Olmifon), prodrug of modafinil, is a mild central nervous system stimulant drug used to relieve excessive sleepiness and inattention, Adrafinil is believed to serve as an alpha-1 adrenoceptor agonist.
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- HY-E70058
-
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α-1-3,4 FucT; Hp3/4FT
|
Endogenous Metabolite
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Metabolic Disease
|
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alpha-1,3/4-Fucosyltransferase (α1,3/4FucT) (EC 2.4.1.65) (Hp3/4FT) can be found in Helicobacter pylori. alpha-1,3/4-Fucosyltransferase (α1,3/4FucT) catalyzes fucose transfer from donor GDP-beta-l-fucose to the GlcNAc [1].
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- HY-P2871A
-
|
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Endogenous Metabolite
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Metabolic Disease
|
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α1-3,6 Galactosidase, Xanthomonas manihotis is a highly specific exoglycosidase that catalyzes the hydrolysis of α1-3 and α1-6 linked galactose residues from oligosaccharides [1].
|
-
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- HY-114695
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-
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- HY-114695S
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-
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- HY-E70116
-
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Glycogen α-1,6-glucanohydrolase
|
Glycosidase
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Others
|
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Isoamylase (Glycogen α-1,6-glucanohydrolase) catalyzes the hydrolysis of α-1,6-glycosidic linkages in glycogen, amylopectin and α/β-limit dextrins [1].
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- HY-P2950A
-
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Glycosidase
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Metabolic Disease
|
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α1-6 Mannosidase, Xanthomonas phaseoli is a highly specific exoglycosidase that removes unbranched α1-6 linked mannose residues from oligosaccharides [1].
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- HY-132177C
-
|
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Glycosidase
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Metabolic Disease
|
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α1-3,4 Fucosidase, Bifidobacterium bifidum is a broad specificity exoglycosidase that catalyzes the hydrolysis of terminal, non-reducing α1-3 and α1-4 linked fucose residues from oligosaccharides and glycoproteins [1].
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- HY-132177A
-
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Glycosidase
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Metabolic Disease
|
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α1-2 Fucosidase (EC 3.2.1.51) is a highly specific exoglycosidase that catalyzes the hydrolysis of linear α1-2 linked fucose residues from oligosaccharides [1].
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-
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- HY-U00333
-
-
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- HY-132177B
-
|
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Glycosidase
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Metabolic Disease
|
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α1-2,4,6 Fucosidase O (EC 3.2.1.51) is a broad specificity exoglycosidase that catalyzes the hydrolysis of terminal α1-2, α1-4 and α1-6 linked fucose residues from oligosaccharides, with α1-6 fucose residues more efficiently [1].
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-
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- HY-B0391S1
-
|
KT-611-d5; BM-15275-d5
|
Isotope-Labeled Compounds
Adrenergic Receptor
|
Cardiovascular Disease
Endocrinology
|
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Naftopidil-d5 is deuterium labeled Naftopidil. Naftopidil (KT-611) is is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes, respectively. Naftopidil has antiproliferative effects. Naftopidil can be used for the research of prostate hyperplasia [1] .
|
-
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- HY-E70029
-
|
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Others
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Others
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alpha-1,6-Fucosidase (LpAlfC(E274A)) (EC 3.2.1.51) cleaves branched non-reducing terminal fucose, linked α(1-6) to the core N-acetylglucosamine of N-linked oligosaccharides. alpha-1,6-Fucosidase (LpAlfC(E274A)) is useful for determining core fucosylation [1].
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-
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- HY-E70061
-
|
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Others
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Others
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alpha-1,3-N-Acetylgalactosaminyltransferase (BgtA) is an acetylgalactose aminotransferase, which can be isolated from Helicobacter mustelae, and can specifically recognize Fucα1,2-Gal epitopes [1].
|
-
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- HY-E70047
-
|
A4GALT
|
Glycosyltransferase
|
Metabolic Disease
|
|
alpha-1,4-Galactosyltransferase (LgtC) (A4GALT) is a glycosphingolipid-specific glycosyltransferase. alpha-1,4-Galactosyltransferase (LgtC) transfers a galactose to the alpha-1,4 position of lactosylceramide to form globotriaosylceramide. alpha-1,4-Galactosyltransferase (LgtC) can be used for the synthesis of P1 blood group antigens [1] .
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-
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- HY-B0391R
-
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KT-611 (Standard); BM-15275 (Standard)
|
Reference Standards
Adrenergic Receptor
|
Cardiovascular Disease
Endocrinology
|
|
Naftopidil (Standard) is the analytical standard of Naftopidil. This product is intended for research and analytical applications. Naftopidil (KT-611) is is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes, respectively. Naftopidil has antiproliferative effects. Naftopidil can be used for the research of prostate hyperplasia [1] .
|
-
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- HY-W705539
-
|
(±)-Phenylephrine-d3 hydrochloride
|
Isotope-Labeled Compounds
Adrenergic Receptor
|
Cardiovascular Disease
|
|
DL-Phenylephrine-d3 hydrochloride ((±)-Phenylephrine-d3 hydrochloride) is the deuterium labeled DL-Phenylephrine hydrochloride (HY-W014726). DL-Phenylephrine ((±)-Phenylephrine) hydrochloride is a selective agonist of the alpha1-adrenergic receptor, exhibiting potent vasoconstrictive activity.
|
-
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- HY-P3835
-
|
|
DNA/RNA Synthesis
|
Endocrinology
|
|
Mating Factor α (1-6) is a mating factor produced by α-mating type cells of Saccharomyces cerevisiae and an acts as an inhibitor of the initiation of DNA synthesis in the cells [1].
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-
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- HY-B1298A
-
|
|
Adrenergic Receptor
|
Cardiovascular Disease
|
|
Methoxamine is a selective alpha1-adrenergic receptor agonist. Methoxamine causes vasoconstriction and increased peripheral vascular resistance [1] . Methoxamine hydrochloride significantly increased the overflow of ATP, ADP and AMP, but not adenosine, by a prazosin-sensitive mechanism in the rabbit pulmonary artery .
|
-
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- HY-B1298
-
|
|
Adrenergic Receptor
|
Neurological Disease
Endocrinology
|
|
Methoxamine hydrochloride is a selective alpha1-adrenergic receptor agonist. Methoxamine hydrochloride causes vasoconstriction and increased peripheral vascular resistance [1] . Methoxamine hydrochloride significantly increased the overflow of ATP, ADP and AMP, but not adenosine, by a prazosin-sensitive mechanism in the rabbit pulmonary artery .
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-
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- HY-N8326
-
|
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Others
|
Others
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|
Maltononaose is a linear oligosaccharide consisting of 9 glucose units linked by alpha-1, 4-glucoside bonds. Maltononaose is used as a substrate to study the subsites affinity of glucoamylase. Maltononaose can be used to determine the activity of amylase and to optimize the process of starch hydrolysis [1] .
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-
- HY-B0391S2
-
|
KT-611-d7; BM-15275-d7
|
Isotope-Labeled Compounds
Adrenergic Receptor
|
Cardiovascular Disease
Endocrinology
|
|
Naftopidil-d7 (KT-611-d7 ) is deuterium labeled Naftopidil. Naftopidil (KT-611) is is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes, respectively. Naftopidil has antiproliferative effects. Naftopidil can be used for the research of prostate hyperplasia [1] .
|
-
- HY-131617
-
|
PGF2α 1,11-lactone
|
Prostaglandin Receptor
|
Others
|
|
Prostaglandin F2α 1,11-lactone is a prostaglandin.
Prostaglandin F2α 1,11-lactone is absorbed by the eye. Prostaglandin F2α 1,
11-Lactone has metabolic stability on the corneal surface and conjunctiva.
Prostaglandin F2α 1,11-lactone can be used in the treatment of glaucoma
[1].
|
-
- HY-116222
-
|
|
Fluorescent Dye
|
Endocrinology
|
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A 53693 is a rigid catecholamine with selective adrenergic agonist activity. A 53693 has affinity for certain rat alpha-2 receptor subtypes. A 53693 shows high selectivity for alpha-2 receptors and, in contrast, has low affinity for alpha-1 receptors. A 53693 is used as a probe in biological studies to explore the molecular interactions of alpha agonist compounds [1].
|
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- HY-158460
-
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Galactose-Alpha-1,3-galactose
|
Biochemical Assay Reagents
|
Others
|
|
Alpha-Gal (Galactose-alpha-1,3-galactose) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans [1].
|
-
- HY-P10437
-
|
human α1-AT(353-372)
|
HIV
|
Infection
|
|
VIRIP (human α1-AT(353-372)) is a HIV-1 inhibitor. VIRIP blocks the entry of HIV-1 by interacting with gp41 fusion peptide. VIRIP can be used for virus research [1].
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-
- HY-153091
-
|
|
Adrenergic Receptor
5-HT Receptor
Sigma Receptor
|
Neurological Disease
|
|
BMY 14802 is a sigma-1 receptor (σ1R) antagonist, as well as an agonist at serotonin (5-HT) 1A and adrenergic alpha-1 receptors. BMY 14802 inhibits abnormal involuntary movement (AIM) in rat Parkinson's disease (PD) model, with down-regulating the expression of AIM [1] .
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-
- HY-14940
-
|
MDL100907; M 100907
|
5-HT Receptor
|
Neurological Disease
|
|
Volinanserin is a potent and selective antagonist of 5-HT2 receptor, with a Ki of 0.36 nM, and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 and DA D2 receptors. Volinanserin has antipsychotic activity.
|
-
- HY-108717A
-
|
|
Ser/Thr Protease
|
Others
|
|
Recombinant Proteinase K (DNase & RNase free, animal free) is a nonspecific serine protease that is useful for general digestion of proteins. Proteinase K is active in the presence of SDS or urea and over a wide range of pH (4-12), salt concentrations, and temperatures. Proteinase K can be use for promoting methods of viral nucleic acid extraction, and detection [1]. This product is of molecular biology grade, free of animal-derived ingredients, and is recombinantly purified from yeast.
|
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- HY-E70052
-
|
GGTA1
|
Endogenous Metabolite
|
Metabolic Disease
|
|
alpha-1,3-Galactosyltransferase (a1,3GalT) (GGTA1) catalyzes the generation of the α-gal glycan via the transfer of a galactose (Gal) in α1-3 linkage, from a uridyl-diphosphate (UDP) donor onto the N-acetyllactosamine (Galβ1,4GlcNAc-R) of glycoproteins. alpha-1,3-Galactosyltransferase (a1,3GalT) is responsible for the synthesis of the α-galactose (α-Gal) epitope found in most mammalian species [1].
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- HY-P2950B
-
|
|
Biochemical Assay Reagents
|
Others
|
|
α-(1-2,3,6) Mannosidase is a glycosidase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture [1].
|
-
- HY-N10639
-
|
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Others
|
Others
|
|
(1α,2α,6β,8α,9α)-1,2,6,8,12-Pentakis(acetyloxy)-9-(benzoyloxy)dihydro-β-agarofuran is a sesquiterpene polyol ester. (1α,2α,6β,8α,9α)-1,2,6,8,12-Pentakis(acetyloxy)-9-(benzoyloxy)dihydro-β-agarofuran can be used for the research of various biochemical [1].
|
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- HY-P5994
-
|
MeOSuc-Ala-Ala-Pro-Phe-CH₂Cl
|
Ser/Thr Protease
|
Others
|
|
MeOSuc-AAPF-CMK (MeOSuc-Ala-Ala-Pro-Phe-CH Cl) is a potent proteinase K inhibitor [1].
|
-
- HY-14940A
-
|
(S)-MDL100907; (S)-M 100907
|
5-HT Receptor
|
Neurological Disease
|
|
(S)-Volinanserin is an isform of Volinanserin (HY-14940). Volinanserin is a potent and selective antagonist of 5-HT2 receptor, with a Ki of 0.36 nM, and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 and DA D2 receptors. Volinanserin has antipsychotic activity.
|
-
- HY-157129
-
|
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AMPK
|
Cardiovascular Disease
|
|
AMPK-α1β1γ1 activator 1 (M1) is an acyl glucuronide metabolite of Indole-3-carboxylic Acid-based AMPK activator. AMPK-α1β1γ1 activator 1 can selectively activated human β1 isoforms with an EC50 value of 38.1nM. AMPK-α1β1γ1 activator 1 can direct binding with human AMPK α1β1γ1 isoform. AMPK-α1β1γ1 activator 1 can be used for the research of diabetic nephropathy [1].
|
-
- HY-15282
-
-
- HY-E70140
-
|
EC 2.4.1; A4GNT
|
Antibiotic
|
Infection
|
|
α-1,4-N-Acetylglucosaminyltransferase 4 (EC 2.4.1, A4GNT) catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans and suppresses H. pylori growth [1].
|
-
- HY-B1116A
-
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(-)-Metaraminol; (-)-erythro-Metaraminol; (-)-m-Hydroxynorephedrine
|
Adrenergic Receptor
|
Neurological Disease
|
|
Metaraminol ((-)-Metaraminol) is a sympathomimetic compound with activity that acts primarily at alpha-1 adrenergic receptors. Metaraminol is used to inhibit hypotension due to vasodilation, particularly in critically ill patients who do not respond well to volume resuscitation. Metaraminol may also be used as an adjunct to help improve cardiac contractility. The use of metaraminol may be supported by less evidence, but its effectiveness in specific situations remains of interest [1].
|
-
- HY-131632
-
|
1a,1b-Dihomo-PGF2α
|
Endogenous Metabolite
|
Others
|
|
1a,1b-Dihomo prostaglandin F2α (1a,1b-Dihomo-PGF2α) is the derivative of Prostaglandin F2α (HY-12956) [1].
|
-
- HY-E70328
-
|
|
Endogenous Metabolite
|
Others
|
|
Alkalophilic Proteinase, Streptomyces sp is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-E70330
-
|
|
Endogenous Metabolite
|
Others
|
|
Neutral Proteinase, Bacillus sp. is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-14940S
-
|
MDL100907-d4 hydrochloride; M 100907-d4 hydrochloride
|
5-HT Receptor
|
Neurological Disease
|
|
Volinanserin-d4 (hydrochloride) is the deuterium labeled Volinanserin hydrochlorid. Volinanserin is a potent and selective antagonist of 5-HT2 receptor, with a Ki of 0.36 nM, and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 and DA D2 receptors. Volinanserin has antipsychotic activity [1] .
|
-
- HY-126988
-
|
α-MAPI
|
Elastase
|
Others
|
|
SP-Chymostatin B (α-MAPI) is a strong inhibitor of many proteases, including chymotrypsin, papain, chymotrypsin-like serine proteinases, chymases, and lysosomal cysteine proteinases such as cathepsins A,B,C, H, and L. SP-Chymostatin B weakly inhibits human leucocyte elastase [1].
|
-
- HY-108717B
-
|
Protease K (NGS grade)
|
Ser/Thr Protease
|
Others
|
|
Proteinase K (Protease K) (NGS grade) (EC 3.4.21.64) is a serine protease with high enzyme activity and broad substrate specificity. Proteinase K can preferentially decompose ester bonds and peptide bonds adjacent to the C-terminus of hydrophobic amino acids, sulfur-containing amino acids, and aromatic amino acids, and is often used to degrade proteins to produce short peptides. This product is NGS grade, no Nickase residue, and nucleic acid residue ≤5pg/mg [1].
|
-
- HY-W145655
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Gal-β1,3-GalNAc-α1-OBn is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-100554
-
|
|
Adrenergic Receptor
5-HT Receptor
|
Cardiovascular Disease
|
|
BMY 7378 is a selective antagonist of α1D-adrenoceptor (α1D-AR). BMY 7378 binds to membranes expressing the cloned rat α1D-AR with a >100-fold higher affinity (Ki=2 nM) than binding to either the cloned rat α1A-AR (Ki=800 nM) or the hamster α1B-AR (Ki=600 nM). BMY 7378 is a 5-HT1A receptor partial agonist [1] .
|
-
- HY-E70194
-
|
V8 protease; Glu-C
|
Ser/Thr Protease
|
Others
|
|
Endoproteinase GluC (V8 protease) is a serine proteinase. Endoproteinase GluC is able to hydrolyze some serpins and all classes of mammalian immunoglobulins [1].
|
-
- HY-131591
-
|
|
Endogenous Metabolite
|
Others
|
|
Digalacturonic acid is a metabolite of pectin or pectic acid. Digalacturonic acid can be used for the co-crystallization of enzymes such as proteinase K [1] .
|
-
- HY-107526
-
|
(Rac)-NFPS
|
GlyT
|
Neurological Disease
|
|
NFPS is a selective, non-competitive glycine transporter-1 (GlyT1) inhibitor with IC50s of 2.8 nM and 9.8 nM for hGlyT1 and rGlyT1, respectively [1]. NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion .
|
-
- HY-158461
-
|
Galactose-Alpha-1,3-galactose, 2-AA labelled
|
Biochemical Assay Reagents
|
Others
|
|
Alpha-Gal standard, 2-AA labelled (Galactose-alpha-1,3-galactose, 2-AA labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans [1].
|
-
- HY-158462
-
|
Galactose-Alpha-1,3-galactose, 2-AB labelled
|
Biochemical Assay Reagents
|
Others
|
|
Alpha-Gal standard, 2-AB labelled (Galactose-alpha-1,3-galactose, 2-AB labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans [1].
|
-
- HY-137412
-
|
Prostaglandin F2α 1,15-lactone
|
Drug Derivative
|
Endocrinology
|
|
PGF2α 1,15-lactone (Prostaglandin F2α 1,15-lactone) is a lipid-soluble internal ester of PGF2α. PGF2α 1,15-lactone decreases menstrual cycle lengths in non-pregnant rhesus monkeys. PGF2α 1,15-lactone terminates early pregnancy in the monkey [1].
|
-
- HY-B2228
-
|
|
Biochemical Assay Reagents
|
Cancer
|
|
Proteinase, Aspergillus oryzae is a serine protease that hydrolyzes peptide bonds in protein substrates, preferring alkaline conditions (optimal pH 10.5). It efficiently degrades casein, poly-L-glutamic acid, and poly-L-lysine, with activity irreversibly inhibited by diisopropylfluorophosphate (DFP) and potato inhibitor. This enzyme catalyzes proteolysis via serine residues in its active site, finding applications in food processing (e.g., soy sauce fermentation), detergents, and leather industries due to its high yield in solid-state fermentation and cost-effective production.
|
-
- HY-W399193
-
|
Prostaglandin F2α 1,9-lactone
|
Prostaglandin Receptor
|
Metabolic Disease
|
|
PGF2α 1,9-lactone (Prostaglandin F2α 1,9-lactone) is a prostaglandin lactone. PGF2α 1,9-lactone shows resistant to hydrolysis by plasma esterases [1].
|
-
- HY-125433
-
|
|
HIV
|
Infection
|
|
A-75925 is a human immunodeficiency virus type 1 (HIV-1) proteinase inhibitor and can be utilized in HIV-1 rersearch [1].
|
-
- HY-E70051
-
|
EC 2.4.1.40(Pm1138)
|
Endogenous Metabolite
|
Others
|
|
alpha-1,3-N-Acetylgalactosaminyltransferase (Pm1138) (EC 2.4.1.40(Pm1138)), also namely the ABO system transferase with glycosyl transferase activity [1].
|
-
- HY-B0661R
-
|
(R)-(-)-YM12617 free base (Standard); LY253351 free base (Standard)
|
Reference Standards
Adrenergic Receptor
Endogenous Metabolite
|
Neurological Disease
Endocrinology
Cancer
|
|
Tamsulosin (Standard) is the analytical standard of Tamsulosin. This product is intended for research and analytical applications. Tamsulosin ((R)-(-)-YM12617 free base) is an inhibitor of α1-adrenergic receptor. Tamsulosin is used for the research of prostatic hyperplasia. Tamsulosin attenuates abdominal aortic aneurysm growth in animal models [1].
|
-
- HY-B0661
-
|
(R)-(-)-YM12617 free base; LY253351 free base
|
Adrenergic Receptor
Apoptosis
|
Neurological Disease
Endocrinology
Cancer
|
|
Tamsulosin ((R)-(-)-YM12617 free base) is an orally active antagonist of α1-adrenergic receptor. Tamsulosin induces Apoptosis. Tamsulosin is used for the research of prostatic hyperplasia. Tamsulosin attenuates abdominal aortic aneurysm growth and inhibits inflammation in animal models [1] .
|
-
- HY-B0661A
-
|
(R)-(-)-YM12617; LY253351
|
Adrenergic Receptor
Apoptosis
|
Neurological Disease
Endocrinology
Cancer
|
|
Tamsulosin hydrochloride ((R)-(-)-YM12617 free base) is an orally active antagonist of α1-adrenergic receptor. Tamsulosin hydrochloride induces Apoptosis. Tamsulosin hydrochloride is used for the research of prostatic hyperplasia. Tamsulosin hydrochloride attenuates abdominal aortic aneurysm growth and inhibits inflammation in animal models [1] .
|
-
- HY-156560
-
|
|
Cathepsin
|
Infection
|
|
Z-LVG is an irreversible cysteine proteinase inhibitor. Z-LVG is a tripeptide derivative from cystatin C which can inhibit viral replication. Z-LVG can be used for virus diseases research [1].
|
-
- HY-19727A
-
FOY 251
2 Publications Verification
|
Ser/Thr Protease
SARS-CoV
|
Metabolic Disease
|
|
FOY 251, an anti-proteolytic active metabolite Camostate (HY-13512), acts as a proteinase inhibitor [1] . FOY 251 inhibits SARS-CoV-2 infection in cells assay [1] .
|
-
- HY-N4332
-
|
|
Ser/Thr Protease
|
Infection
Cancer
|
|
Rivulariapeptolides 1121 is a high potent and selective serine protease inhibitor with IC50 values of 35.52 nM, 13.24 nM and 48.05 nM for chymotrypsin, elastase and proteinase K, respectively [1].
|
-
- HY-168641
-
|
|
PROTACs
Apoptosis
HIF/HIF Prolyl-Hydroxylase
|
Cancer
|
|
PROTAC HIF-1α degrader-1 (compound V2) is a potent hypoxia-inducible factor-1α (HIF-1α) PROTAC degrader with an IC50 value of 7.54 µM. PROTAC HIF-1α degrader-1 shows anti-proliferative activity. PROTAC HIF-1α degrader-1 decreases the HIF-1α protein expression. PROTAC HIF-1α degrader-1 induces apoptosis. (Pink: ligand for target protein (HY-111387); black: linker (HY-W013731); Blue: E3 ligase ligand (HY-112078)) [1].
|
-
- HY-E70157
-
|
EC:2.4.1.68; FUT8; α1-6FucT
|
Glucosylceramide Synthase (GCS)
|
Infection
|
|
Fucosyltransferase 8 (EC:2.4.1.68; FUT8; α1-6FucT) is a glycosyl transferase and catalyzes the transfer of a fucose residue from GDP-fucose to the innermost N-acetylglucosamine residue of N-glycans [1].
|
-
- HY-114656
-
-
- HY-B2193
-
|
|
Amylases
|
Others
|
|
α-Amylase is a hydrolase enzyme that catalyses the hydrolysis of internal α-1, 4-glycosidic linkages in starch to yield products like glucose and maltose.
|
-
- HY-19727
-
-
- HY-134910
-
|
|
Virus Protease
|
Infection
|
|
SID-852843 is a WNV NS2B-NS3 proteinase inhibitor. SID-852843 can inhibit WNV NS2B-NS3 proteinase activity with IC50 value of 0.105 μM. SID-852843 can be used for the research of virus infection [1].
|
-
- HY-P4911
-
|
|
CXCR
|
Cardiovascular Disease
|
|
SDF-1α (human) is a mononuclear cells chemoattractant that can bind to CXCR4. SDF-1α plays a central role in stem cell homing, retention, survival, proliferation, cardiomyocyte repair, angiogenesis and ventricular remodelling following myocardial infarction. SDF-1α (human) can be used in cardiovascular disease research [1] .
|
-
- HY-149635
-
|
|
HIF/HIF Prolyl-Hydroxylase
|
Cancer
|
|
HIF-1α-IN-6 (compound 3s) is a HIF-1α inhibitor with IC50 values of 0.6 and 53.3 nM observed in MiaPaCa-2 and MDA-MB-231 cells. HIF-1α-IN-6 can inhibit HIF-1α expression by decreasing the level of HIF-1α mRNA [1].
|
-
- HY-P4911A
-
|
|
CXCR
|
Cardiovascular Disease
|
|
SDF-1α (human) TFA is a mononuclear cells chemoattractant that can bind to CXCR4. SDF-1α plays a central role in stem cell homing, retention, survival, proliferation, cardiomyocyte repair, angiogenesis and ventricular remodelling following myocardial infarction. SDF-1α (human) TFA can be used in cardiovascular disease research [1] .
|
-
- HY-N4331
-
|
|
Ser/Thr Protease
|
Infection
Cancer
|
|
Rivulariapeptolides 1185 is a high potent and selective serine protease inhibitor with IC50 values of 13.17 nM, 23.59 nM and 55.26 nM for chymotrypsin, elastase and proteinase K, respectively [1].
|
-
- HY-N4333
-
|
|
Ser/Thr Protease
|
Infection
Cancer
|
|
Rivulariapeptolides 988 is a high potent and selective serine protease inhibitor with IC50 values of 95.46 nM, 15.29 nM and 85.50 nM for chymotrypsin, elastase and proteinase K, respectively [1].
|
-
- HY-D1532
-
|
|
Parasite
|
Others
|
|
DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS is a fluorescent dye, and can be applied in a fluorogenic substrate for an aspartyl proteinase from human malaria parasite [1].
|
-
- HY-114174
-
|
|
Amyloid-β
|
Neurological Disease
|
|
Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing [1].
|
-
- HY-129953S1
-
-
- HY-124085
-
-
- HY-108137
-
|
|
Cathepsin
HSV
SARS-CoV
|
Infection
Inflammation/Immunology
|
|
Z-LVG-CHN2 is a cell-permeable and irreversible inhibitor of cysteine proteinase. Z-LVG-CHN2 is a tripeptide derivative and mimics part of the human cysteine proteinase-binding center. Z-LVG-CHN2 displays an inhibition on HSV whereas no significant effect on poliovirus replication. Z-LVG-CHN2 effectively blocks SARS-COV-2 replication (EC50=190 nM) via inhibition of SARS-COV-2 3CL pro protease .
|
-
- HY-115903A
-
|
|
HIF/HIF Prolyl-Hydroxylase
|
Cancer
|
|
HIF-1α-IN-2 hydrochloride is an effective HIF-1α inhibitor with anticancer potencies (IC50s of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively). HIF-1α-IN-2 hydrochloride suppresses HIF-1α expression by blocking transcription and protein translation [1].
|
-
- HY-151344
-
|
|
HIF/HIF Prolyl-Hydroxylase
|
Cancer
|
|
HIF-1/2α-IN-2 is an inhibitor of HIF-1/2α. HIF-1/2α-IN-2 decrease HIF-1/2α levels and induces iron starvation response by targeting Iron Sulfur Cluster Assembly 2 (ISCA2) [1].
|
-
- HY-122762
-
|
DV-1006
|
Ser/Thr Protease
|
Inflammation/Immunology
|
|
Cetraxate hydrochloride (DV-1006), an orally active anti-ulcer agent with mucosal protective effects, can be used for gastric ulcers research [1]. Cetraxate hydrochloride is a potent acrosomal proteinase acrosin inhibitor with a Ki and an IC50 of 0.94 μM and 3.3 μM, respectively .
|
-
- HY-115903
-
|
|
HIF/HIF Prolyl-Hydroxylase
|
Cancer
|
|
HIF-1α-IN-2 is an effective HIF-1α inhibitor with anticancer potencies (IC50s of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively). HIF-1α-IN-2 suppresses HIF-1α expression by blocking transcription and protein translation [1].
|
-
- HY-162368
-
|
|
Phospholipase
|
Others
|
|
cPLA2α-IN-2 (Compound 122) is an inhibitor of cytosolic phospholipase A2α (cPLA2α) .
|
-
- HY-124079
-
-
- HY-118754
-
-
- HY-129953S
-
-
- HY-34663
-
|
(2R)-2-(tert-Butoxycarbonylamino)-2-phenylethanoic acid; (R)-2-((tert-Butoxycarbonyl)amino)-2-phenylacetic acid; (R)-2-[(tert-Butoxycarbonyl)amino]-2-phenylacetic acid
|
Amino Acid Derivatives
|
Others
|
|
(αR)-α-[[(1,1-Dimethylethoxy)carbonyl]amino]benzeneacetic acid is a Glycine (HY-Y0966) derivative [1].
|
-
![(αR)-α-[[(1,1-Dimethylethoxy)carbonyl]amino]benzeneacetic acid](//file.medchemexpress.com/product_pic/hy-34663.gif)
- HY-108137A
-
|
|
Cathepsin
HSV
SARS-CoV
|
Infection
|
|
Z-L(D-Val)G-CHN2 is the isoform of Z-LVG-CHN2 (HY-108137). Z-LVG-CHN2 is a cell-permeable and irreversible inhibitor of cysteine proteinase. Z-LVG-CHN2 is a tripeptide derivative and mimics part of the human cysteine proteinase-binding center. Z-LVG-CHN2 displays an inhibition on HSV whereas no significant effect on poliovirus replication. Z-LVG-CHN2 effectively blocks SARS-COV-2 replication (EC50=190 nM) via inhibition of SARS-COV-2 3CL pro protease .
|
-
- HY-13671
-
|
HIF-1α inhibitor; LW8
|
HIF/HIF Prolyl-Hydroxylase
Apoptosis
|
Cancer
|
|
LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor with an IC50 value of 4.4 μM, and it is also an inhibitor of MDH2. LW6 decreases HIF-1α protein expression without affecting HIF-1β expression.
|
-
- HY-157660
-
|
|
Drug Isomer
|
Others
|
|
15(R)-Prostaglandin F1α (compound 10) is the C-15 epimer of PGF1α .
|
-
- HY-149588
-
|
|
Others
|
Endocrinology
|
|
17-Trifluoromethylphenyl trinor prostaglandin F2α methyl ester is an analog of PGF2α .
|
-
- HY-145418
-
|
|
IRE1
|
Others
|
|
IRE1α kinase-IN-3 (compound 2) is a potent IRE1α inhibitor with an Ki of 480 nM. IRE1α kinase-IN-3 is the ATP-competitive ligands of IRE1α .
|
-
- HY-145419
-
|
|
IRE1
|
Others
|
|
IRE1α kinase-IN-4 (compound 6) is a potent IRE1α inhibitor with an Ki of 140 nM. IRE1α kinase-IN-4 is the ATP-competitive ligands of IRE1α .
|
-
- HY-145420
-
|
|
IRE1
|
Others
|
|
IRE1α kinase-IN-5 (compound 7) is a potent IRE1α inhibitor with an Ki of 98 nM. IRE1α kinase-IN-5 is the ATP-competitive ligands of IRE1α .
|
-
- HY-P2968
-
|
|
Amylases
|
Others
|
|
Bacterial α-Amylase catalyses the hydrolysis of internal α-1,4-glycosidic linkages in starch in low molecular weight products, such glucose, maltose and maltotriose units. Bacterial α-Amylase is often used in biochemical studies [1].
|
-
- HY-W013097
-
|
|
Amino Acid Derivatives
|
Others
|
|
Boc-Arg(di-Z)-OH can be used for the synthesis of amino acid. Boc-Arg(di-Z)-OH can be used for the research of inhibitors for processing proteinases. Boc-Arg(di-Z)-OH is coupled via the mixed anhydride (MA) with HGlu(OBzl)-Lys(Z)-Arg(Z,Z)-CH2Cl [1].
|
-
- HY-147813
-
-
- HY-168800
-
-
- HY-163370
-
-
- HY-163376
-
|
17-CF3PTPG2α EA
|
Prostaglandin Receptor
|
Metabolic Disease
|
|
17-Trifluoromethylphenyl trinor prostaglandin F2α ethyl amide (compound 17-CF3PTPG2α EA) is a lipophilic analog of 17-trifluoromethylphenyl trinor PGF2α .
|
-
- HY-15157
-
|
1α, 24, 25-Trihydroxy VD3
|
VD/VDR
|
Metabolic Disease
|
|
Calcitetrol(1α, 24, 25-Trihydroxy VD3) is the hormonally active form of vitamin D with three hydroxyl groups.
|
-
- HY-151465
-
|
|
HIF/HIF Prolyl-Hydroxylase
|
Cancer
|
|
HIF-1α-IN-4 is a HIF-1α inhibitor with an IC50 value of 24 nM (in HEK293T cell). HIF-1α-IN-4 downregulates VEGF and PDK1 mRNA expressions under hypoxia. HIF-1α-IN-4 can be used in the research of cancer [1].
|
-
- HY-153474
-
|
|
IRE1
|
Others
|
|
IRE1α kinase-IN-8, a benzoheterocyclecarboxaldehyde derivative, is a potent IRE-1α inhibitor. IRE1α kinase-IN-8 can be used for research in diseases associated with the unfolded protein response or with regulated IRE1-dependent decay (RIDD) [1].
|
-
- HY-158458
-
|
A2[3]G1F1(a1-3) glycan
|
Biochemical Assay Reagents
|
Others
|
|
A2[3]G1F1(α-1-3) glycan (A2[3]G1F1(a1-3) glycan) is an asymmetric Lewis X polysaccharide and N-glycan. SLeX is a ligand for the cell adhesion molecule E-selectin, which is specifically expressed at sites of inflammatory lesions. Designing SLeX-polysaccharide conjugates to deliver drugs to inflammatory lesions [1].
|
-
![A2[3]G1F1(α-1-3) glycan](//file.medchemexpress.com/product_pic/hy-158458.gif)
- HY-113358S
-
-
- HY-137012S
-
-
- HY-E70569
-
|
|
Biochemical Assay Reagents
|
Others
|
|
α-N-acetylgalactosidase (EC 3.2.1.4) is a highly specific exoglycosidase that efficiently hydrolyzes α-N-acetylgalactosamine (GalNAc) linked to serine or threonine residues in glycoproteins (Tn antigen). α-N-acetylgalactosidase shows activity against α 1-3 linked terminal GalNAc [1]. α-N-acetylgalactosidase is suitable for use in the pH range of 6.0-7.6 and does not require cofactors or special buffer systems.
|
-
- HY-151466
-
|
|
HIF/HIF Prolyl-Hydroxylase
Monoamine Oxidase
|
Cancer
|
|
HIF-1α-IN-5 is a HIF-1α inhibitor with an IC50 value of 24 nM (in HEK293T cell). HIF-1α-IN-5 also inhibits MAO-A activity. HIF-1α-IN-5 downregulates VEGF and PDK1 mRNA expressions under hypoxia. HIF-1α-IN-5 can be used in the research of cancer [1].
|
-
- HY-153475
-
|
|
IRE1
|
Cancer
|
|
IRE1α kinase-IN-9 (compound 2) is a potent IRE-1α inhibitor，exhibits an average IC50 value of <0.1 μM. IRE1α kinase-IN-9 can be used for research in diseases associated with the unfolded protein response or with regulated IRE1-dependent decay (RIDD) [1].
|
-
- HY-151341
-
|
|
HIF/HIF Prolyl-Hydroxylase
|
Cancer
|
|
HIF-1/2α-IN-1 is an orally active HIF-2α inhibitor. HIF-1/2α-IN-1 inhibits HIF-2α activity with an IC50 value of 0.92 μM. HIF-1/2α-IN-1 also can decrease HIF-1α levels. HIF-1/2α-IN-1 can be used for the research of clear cell renal cell carcinoma (ccRCC) [1].
|
-
- HY-106448
-
|
MR 889
|
Ser/Thr Protease
|
Inflammation/Immunology
|
|
Midesteine (MR 889) is a proteinase inhibitor that can inhibit porcine pancreatic elastase, human neutrophil elastase and bovine chymotrypsin. Midesteine has the potential for chronic obstructive pulmonary disease (COPD) and chronic bronchitis research [1].
|
-
- HY-163360
-
|
|
PI3K
|
Cancer
|
|
PI3Kα-IN-19 (Compound 1) is a PI3Kα inhibitor with a targeted binding site at the p110α catalytic subunit. PI3Kα is one of the most common dysregulated kinases used in cancer research [1].
|
-
- HY-120337
-
|
|
Choline Kinase
|
Cancer
|
|
V-11-0711 is a potent and selective choline kinase alpha (ChoKα) inhibitor with an IC50 of 20 nM. V-11-0711 causes a reversible growth arrest in HeLa cells [1].
|
-
- HY-129397S
-
|
2,3-Dinor-11β-PGF2α-d9, 2,3-dinor-11-epi PGF2α-d9
|
Isotope-Labeled Compounds
|
Others
|
|
2,3-Dinor-11β-prostaglandin F2α-d9 is the deuterium labeled 2,3-Dinor-11β-prostaglandin F2α .
|
-
- HY-106769C
-
|
GR50360 hydrochloride
|
Adrenergic Receptor
|
Neurological Disease
|
|
Fluparoxan hydrochloride is an orally active, selective and competitive alpha 2-adrenoceptor antagonist. Fluparoxan hydrochloride is an anti-depressant agent [1] .
|
-
- HY-106769
-
-
- HY-P2871
-
|
EC 3.2.1.22
|
Endogenous Metabolite
|
Others
|
|
α-Galactosidase, Aspergillus niger (EC 3.2.1.22), that is, α-galactosidase, is a glycoside hydrolase that widely exists in animals, plants and microorganisms, and is often used in biochemical research. α-Galactosidase catalyzes the hydrolysis of α-1,6-linked terminal galactose residues, including galactooligosaccharides, galactomannans, and galactolipids. Catalyzes many catabolic processes including cleavage of glycoproteins, glycolipids and polysaccharides [1].
|
-
- HY-U00399
-
|
|
Adrenergic Receptor
|
Endocrinology
|
|
Fiduxosin is a potent α1-adrenoceptor antagonist, with Ki of 0.160 nM, 24.9 nM, and 0.920 nM for α1a-, α1b-, and α1d-adrenoceptors, respectively.
|
-
- HY-101300
-
|
LD 3098 hydrochloride
|
Adenosine Receptor
|
Neurological Disease
|
|
Cirazoline hydrochloride (LD 3098 hydrochloride) is a potent competitive full α1A-adrenergic receptor (α1A-AR) agonist (Ki=120 nM) and only a partial agonist at α1B-AR (Ki= 960 nM) and α1D-AR (Ki=660 nM) [1].
|
-
- HY-100943
-
|
SQ 10643
|
5-HT Receptor
Influenza Virus
|
Infection
Inflammation/Immunology
|
|
Cinanserin hydrochloride (SQ 10643) is a potent, selective and highly affinity 5-HT2 receptor antagonist with a Ki of 41 nM. Cinanserin hydrochloride has a much higher binding affinity for the 5-HT2 than for the 5-HT1 receptor (Ki of 3500 nM). Cinanserin is also an inhibitor of 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro [1] .
|
-
- HY-U00399A
-
|
ABT 980
|
Adrenergic Receptor
|
Endocrinology
|
|
Fiduxosin hydrochloride (ABT 980) is a potent α1-adrenoceptor antagonist, with Ki of 0.160 nM, 24.9 nM, and 0.920 nM for α1a-, α1b-, and α1d-adrenoceptors, respectively [1].
|
-
- HY-E70304
-
|
MAN1A1
|
Endogenous Metabolite
|
Others
|
|
Mannosyl-oligosaccharide 1,2-α-mannosidase IA (MAN1A1) is a glycosidase that catalyzes the hydrolysis of α-1,2-linked mannose residues in Man(9)GlcNAc(2) to produce Man(9)GlcNAc(2) [1].
|
-
- HY-113097
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
3α,7α-Dihydroxycoprostanic acid is an endogenous metabolite. 3α,7α-Dihydroxycoprostanic acid, a bile acid, is the precursor to chenodeoxycholic acid [1].
|
-
- HY-P0091
-
|
Thymosin α1
|
Influenza Virus
|
Cancer
|
|
Thymalfasin is an immunomodulating agent able to enhance the Thl immune response.
|
-
- HY-173488
-
|
|
NF-κB
HIF/HIF Prolyl-Hydroxylase
Keap1-Nrf2
|
Cancer
|
|
NF-κB/HIF-1α-IN-1 (compound 9c) is a potent blocker of the NF-κB activation pathway and demonstrates selective anti-fibrotic activity. NF-κB/HIF-1α-IN-1 shows no significant cytotoxicity in NCI tumor cell lines. In rat models. NF-κB/HIF-1α-IN-1 has been shown to effectively ameliorate liver fibrosis by inhibiting the expression levels of NF-κB and HIF-1α, while simultaneously inducing the activation of Nrf2 [1].
|
-
- HY-B0471
-
-
- HY-B0371B
-
|
|
Adrenergic Receptor
|
Endocrinology
|
|
(R)-Terazosin is an active R-enantiomer of Terazosin. (R)-Terazosin is a potent α1-adrenoceptor antagonist with Ki values of 6.51 nM, 1.01 nM and 1.97 nM for α1a, α1b and α1d-adrenoceptor, respectively [1].
|
-
- HY-N3994
-
|
|
Drug Intermediate
|
Others
|
|
16α,17α-Epoxyprogesterone is an important steroid, serving as an intermediate for many hormonal drugs such as Hydrocortisone (HY-N0583) and Megestrol (HY-B1834). 16α,17α-Epoxyprogesterone can further biotransform into another significant intermediate, 11α-hydroxy-16α,17α-epoxyprogesterone, to manufacture additional compounds [1].
|
-
- HY-131368R
-
|
|
Endogenous Metabolite
|
Others
|
|
α,α-Trehalose 6-phosphate (potassium) (Standard) is the analytical standard of α,α-Trehalose 6-phosphate (potassium). This product is intended for research and analytical applications. α,α-Trehalose 6-phosphate (Tre6P) potassium is an endogenous metabolite. α,α-Trehalose 6-phosphate is a 6-phosphate derivative of α,α′-trehalose. α,α-Trehalose 6-phosphate is rapidly converted to the pathway end product, α,α′-trehalose, through the action of Tre6P phosphatase (T6PP) [1].
|
-
- HY-N2464
-
|
Amylotetraose; Fujioligo 450; α-1,4-Tetraglucose
|
TNF Receptor
Endogenous Metabolite
Bacterial
Integrin
NF-κB
|
Cardiovascular Disease
Inflammation/Immunology
|
|
Maltotetraose can serve as a substrate for enzyme-linked assays to measure amylase activity in biological fluids. Maltotetraose has oral active, and reduces TNF-α-induced inflammatory responses by inhibiting NF-κB activity and decreasing ICAM-1 expression. Maltotetraose also inhibits PDGF-induced vascular smooth muscle cell migration and neovascularization. Additionally, Maltotetraose derivatives can function as probes for detecting bacterial infections by targeting the maltodextrin transporter. With good long-term safety, Maltotetraose holds promise for research in atherosclerosis-related diseases [1] .
|
-
- HY-10122
-
|
KAD 3213; KMD 3213
|
Adrenergic Receptor
Bacterial
|
Endocrinology
Cancer
|
|
Silodosin (KAD 3213; KMD 3213) is a potent, selective and orally active α1A-adrenergic receptor (α1A-AR) blocker. Silodosin exhibits high affinity for α1A-AR (Ki=0.036 nM), over 162-fold and 50-fold than for α1B-AR and α1D-AR with Ki values of 21 nM and 2.0 nM, respectively. Silodosin is an effective and well-tolerated agent, it can be used for the investigation of LUTS/BPH [1] .
|
-
- HY-N15362
-
|
|
Endogenous Metabolite
|
Endocrinology
|
|
5α-Pregnane-3β,17α,20α-triol is an endogenous steroid compound. 5α-Pregnane-3β,17α,20α-triol is the metabolite of Pregnenolone (HY-B0151) or Progesterone (HY-N0437). 5α-Pregnane-3β,17α,20α-triol is promising for research of the endocrine function of the placenta and the mechanisms related to steroid hormone metabolism during pregnancy [1].
|
-
- HY-B0484
-
|
|
Adrenergic Receptor
|
Cardiovascular Disease
|
|
Buflomedil hydrochloride, a vasodilator agent, is an orally active α1A-adrenoceptor antagonist with Kis of 4.06 µM and 6.84 µM for α1A-AR and α1B-AR, respectively. Buflomedil hydrochloride can be used for the study of peripheral circulatory disorders [1] .
|
-
- HY-B0484A
-
|
|
Adrenergic Receptor
|
Cardiovascular Disease
|
|
Buflomedil, a vasodilator agent, is an orally active α1A-adrenoceptor antagonist with Kis of 4.06 µM and 6.84 µM for α1A-AR and α1B-AR, respectively. Buflomedil can be used for the study of peripheral circulatory disorders [1] .
|
-
- HY-107850A
-
|
Allopregnanediol
|
GnRH Receptor
|
Endocrinology
|
|
5α-Pregnane-3α,20α-diol (Allopregnanediol) is a derivative of progesterone and is one of the various steroids secreted by the ovaries of rats. 5α-Pregnane-3α,20α-diol can significantly stimulate the release of luteinizing hormone (LH) in castrated rats that have been pre-treated with estrogen, while simultaneously inhibiting the secretion of follicle-stimulating hormone (FSH) [1].
|
-
- HY-D1606
-
|
|
Adrenergic Receptor
|
Metabolic Disease
|
|
BODIPY FL prazosin is a fluorescent α1-adrenergic antagonist with Ki values of 14.5, 43.3 nM for α1a-AR and α1b-AR, respectively. BODIPY FL prazosin also is a fluorescent ligand with the excitation and emission wavelengths are 485 and 535 nm, respectively. BODIPY FL prazosin can be used for study the differences in the subcellular localization of α1-adrenoceptor subtypes [1] .
|
-
- HY-10122S
-
|
|
Isotope-Labeled Compounds
Adrenergic Receptor
|
Endocrinology
Cancer
|
|
Silodosin-d4 is the deuterium labeled Silodosin. Silodosin (KAD 3213) is a potent, selective and orally active α1A-adrenergic receptor (α1A-AR) blocker. Silodosin exhibits high affinity for α1A-AR (Ki=0.036 nM), over 162-fold and 50-fold than for α1B-AR and α1D-AR with Ki values of 21 nM and 2.0 nM, respectively. Silodosin is an effective and well-tolerated agent, it can be used for the investigation of LUTS/BPH [1] .
|
-
- HY-17538
-
-
- HY-123368
-
|
|
Adrenergic Receptor
|
Cardiovascular Disease
|
|
Zolertine hydrochloride is an α-adrenoceptor antagonist with a pKi of 6.81 in rat liver (α1B-adrenoceptors) and 6.35 in rabbit liver (α1A-adrenoceptors) membranes [1].
|
-
- HY-W722556
-
|
3α,5α-Androstanol
|
GABA Receptor
Constitutive Androstane Receptor
|
Metabolic Disease
|
|
5α-Androstan-3α-ol is a γ-aminobutyric acid (GABA) receptor agonist. 5α-Androstan-3α-ol can inhibit the transcriptional activity of the orphan nuclear receptor CAR (constitutive androstane receptor). 5α-Androstan-3α-ol negatively regulates the activity of CAR by binding to CAR and promoting its dissociation from coactivator proteins. 5α-Androstan-3α-ol can be used to study nuclear receptor-mediated hormone metabolism and drug detoxification mechanisms [1].
|
-
- HY-E70076
-
|
Bacillopeptidaseb
|
Biochemical Assay Reagents
|
Others
|
|
Subtilisin (Compound proteinase) (EC 3.4.21.62) is a proteolytic enzyme, isolated from Bacillus licheniformis. Subtilisin (Compound proteinase) has catalytic activity in anhydrous dimethyl formamide. Subtilisin (Compound proteinase) can be used as a catalyst for easy coupling between sugars and amino acids [1] .
|
-
- HY-101300R
-
|
LD 3098 hydrochloride (Standard)
|
Reference Standards
Adenosine Receptor
|
Neurological Disease
|
|
Cirazoline (hydrochloride) (Standard) is the analytical standard of Cirazoline (hydrochloride). This product is intended for research and analytical applications. Cirazoline hydrochloride (LD 3098 hydrochloride) is a potent competitive full?α1A-adrenergic receptor (α1A-AR) agonist (Ki=120 nM) and only a partial agonist at α1B-AR (Ki= 960 nM) and α1D-AR (Ki=660 nM) [1].
|
-
- HY-113097S1
-
-
- HY-116982
-
|
|
Adrenergic Receptor
5-HT Receptor
|
|
|
BMY 7378 (free base) is a selective antagonist of α1D-adrenoceptor (α1D-AR). BMY 7378 (free base) binds to membranes expressing the cloned rat α1D-AR with a >100-fold higher affinity (Ki=2 nM) than binding to either the cloned rat α1A-AR (Ki=800 nM) or the hamster α1B-AR (Ki=600 nM). BMY 7378 (free base) is a 5-HT1A receptor partial agonist [1] .
|
-
- HY-10122R
-
|
KAD 3213 (Standard); KMD 3213 (Standard)
|
Reference Standards
Adrenergic Receptor
Bacterial
|
Endocrinology
Cancer
|
|
Silodosin (Standard) is the analytical standard of Silodosin. This product is intended for research and analytical applications. Silodosin (KAD 3213; KMD 3213) is a potent, selective and orally active α1A-adrenergic receptor (α1A-AR) blocker. Silodosin exhibits high affinity for α1A-AR (Ki=0.036 nM), over 162-fold and 50-fold than for α1B-AR and α1D-AR with Ki values of 21 nM and 2.0 nM, respectively. Silodosin is an effective and well-tolerated agent, it can be used for the investigation of LUTS/BPH [1] .
|
-
- HY-106954
-
|
Rec 15/2739; Recordati 15/2739; SB 216469
|
Adrenergic Receptor
|
Inflammation/Immunology
|
|
Upidosin (Rec 15/2739) is an α-1 adrenoceptor (α-1 AR) antagonist. Upidosin shows moderate selectivity for the α-1A AR subtype. Upidosin shows uroselectivity in urethra and prostate with a Kb value of 2-3 nM higher than in ear artery and aorta with a Kb value of 20-100 nM. Upidosin inhibits [3H]prazosin binding to cloned human α-1A adrenergic receptor. Upidosin can be used for the research of urethral obstruction [1].
|
-
- HY-N0176A
-
|
α-Dihydroqinghaosu; α-Artenimol
|
Drug Metabolite
Parasite
|
Infection
|
|
α-Dihydroartemisinin (α-Dihydroqinghaosu; α-Artenimol) is a antimalarial agent that can be found in Artemisia annua L [1].
|
-
- HY-113097S
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
3α,7α-Dihydroxycoprostanic acid-d3 is the deuterium labeled 3α,7α-Dihydroxycoprostanic acid (HY-113097) [1]. 3α,7α-Dihydroxycoprostanic acid is an endogenous metabolite. 3α,7α-Dihydroxycoprostanic acid, a bile acid, is the precursor to chenodeoxycholic acid .
|
-
- HY-116379
-
|
|
Adrenergic Receptor
|
Metabolic Disease
|
|
RS-100329 is an α1-adrenergic receptor (α1-AR) antagonist that effectively inhibits α1-adrenergic receptor-mediated contractions of lower urinary tract tissues in vitro and in vivo. RS-100329 can be used in the research of symptoms related to benign prostatic hyperplasia [1].
|
-
- HY-B0471S
-
|
(R)-(-)-Phenylephrine-d3 (hydrochloride); L-Phenylephrine-d3 (hydrochloride)
|
Adrenergic Receptor
Endogenous Metabolite
|
Cardiovascular Disease
Endocrinology
|
|
Phenylephrine-d3 (hydrochloride) is the deuterium labeled Phenylephrine hydrochloride. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.
|
-
- HY-B0471S3
-
-
- HY-133971
-
|
5α,6α-Epoxycholesterol
|
Liposome
|
Others
|
|
Cholesterol-5α,6α-epoxide is an epoxide derivative of cholesterol formed by the enzymatic oxidation of cholesterol in the liver and other tissues. Cholesterol-5α,6α-epoxide has unique chemical properties that make it an important intermediate in the biosynthesis of bile acids, which play a key role in the digestion and absorption of dietary fats. It also has a potential physiological role in regulating cholesterol metabolism and transport, although its biological function is not fully understood.
|
-
- HY-15536A
-
|
GRT6005 (1α,4α)stereoisomer
|
Opioid Receptor
|
Neurological Disease
|
|
Cebranopadol ((1α,4α)stereoisomer) is a stereoisomer of cebranopadol. Cebranopadol is a potent agonist activity on ORL-1.
|
-
- HY-B0471S2
-
-
- HY-137393
-
-
- HY-146225
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Amylase/α-Glucosidase-IN-2 (compound 5) is a potent α-amylase and α-glucosidase dual inhibitor with IC50 values of 13.02, 13.09 µM for α-amylase and α-glucosidase, respectively. α-Amylase/α-Glucosidase-IN-2 has the potential for the research of diabetic complications [1].
|
-
- HY-B0471R
-
|
(R)-(-)-Phenylephrine hydrochloride (Standard); L-Phenylephrine hydrochloride (Standard)
|
Reference Standards
Adrenergic Receptor
Endogenous Metabolite
|
Cardiovascular Disease
Endocrinology
Cancer
|
|
Phenylephrine (hydrochloride) (Standard) is the analytical standard of Phenylephrine (hydrochloride). This product is intended for research and analytical applications. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.
|
-
- HY-147711
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Amylase/α-Glucosidase-IN-1 (compound 33) is a potent α-amylase/α-glucosidase inhibitor with IC50s of 2.01, 2.09 µM for α-amylase and α-glucosidase, respectively. Kinetic studies predict that α-Amylase/α-Glucosidase-IN-1 has the potential of anti hyperglycemia [1].
|
-
- HY-131368A
-
|
Tre6P
|
Endogenous Metabolite
|
Others
|
|
α,α-Trehalose 6-phosphate (T6P) is an endogenous metabolite. α,α-Trehalose 6-phosphate is a 6-phosphate derivative of α,α′-trehalose. α,α-Trehalose 6-phosphate is rapidly converted to the pathway end product, α,α′-trehalose, through the action of Tre6P phosphatase (T6PP) [1].
|
-
- HY-131368
-
|
Tre6P potassium
|
Endogenous Metabolite
|
Others
|
|
α,α-Trehalose 6-phosphate (Tre6P) potassium is an endogenous metabolite. α,α-Trehalose 6-phosphate is a 6-phosphate derivative of α,α′-trehalose. α,α-Trehalose 6-phosphate is rapidly converted to the pathway end product, α,α′-trehalose, through the action of Tre6P phosphatase (T6PP) [1].
|
-
- HY-100980
-
|
BE2254 hydrochloride
|
Adrenergic Receptor
|
Neurological Disease
Cancer
|
|
HEAT (BE2254) hydrochloride is a selective alpha 1 adrenergic receptor antagonist. HEAT hydrochloride, a phenethylamine derivative, shows pKis of 9, 9.1, and 8.57 for alpha 1a, alpha 1b and alpha 1c, respectively [1] .
|
-
- HY-116623
-
|
|
Adrenergic Receptor
|
Endocrinology
|
|
A-123189 is a selective and potent α1D antagonist with Kis of 0.312 and 0.17 for human α1D and rat α1D, respectively. A-123189 displays selectivities between 10- to 20-fold for the α1D receptor over the human α1A and rat α1A receptors [1].
|
-
- HY-174319
-
|
|
Amylases
Glycosidase
|
Metabolic Disease
|
|
α-Amylase/α-Glucosidase-IN-20 (Compound 6b) is a dual inhibitor of α-Amylase and α-Glucosidase with IC50s of 414.57 and 924.15 μM for α-Amylase and α-Glucosidase, respectively. α-Amylase/α-Glucosidase-IN-20 shows a potent anti-diabetic activity, promising for diabetes research [1].
|
-
- HY-133971S
-
-
- HY-150857S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Thymine-α,α,α,6-d4 Glycol (mixture of diastereomers)-d4 is the deuterium labeled Thymine-α,α,α,6-d4 Glycol (mixture of diastereomers) [1].
|
-
- HY-B0471S1
-
|
(R)-(-)-Phenylephrine-2,4,6-d3 (hydrochloride); L-Phenylephrine-2,4,6-d3 (hydrochloride)
|
Adrenergic Receptor
Endogenous Metabolite
|
Cardiovascular Disease
Endocrinology
|
|
Phenylephrine-2,4,6-d3 (hydrochloride) is the deuterium labeled Phenylephrine hydrochloride. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.
|
-
- HY-10122A
-
|
(Rac)-KAD 3213; (Rac)-KMD 3213
|
Adrenergic Receptor
|
Endocrinology
|
|
(Rac)-Silodosin ((Rac)-KAD 3213) is the racemate of Silodosin (HY-10122). Silodosin is a potent, selective and orally active α1A-adrenergic receptor (α1A-AR) blocker [1].
|
-
- HY-P5158
-
|
|
Adrenergic Receptor
|
Others
|
|
Conopeptide rho-TIA is a peptide derived from the venom contained in the predatory sea snail Conus tulipa, has highly selective and noncompetitive inhibitor at human α1B-Adrenergic Receptor. Conopeptide rho-TIA acts a competitive inhibitor at human α1A-Adrenergic Receptor and α1D-Adrenergic Receptor. Conopeptide rho-TIA binds to each subtype and may provide useful information for the development of novel α1-Adrenergic Receptor subtype-selective drugs [1].
|
-
- HY-168961
-
|
|
Amylases
Glycosidase
|
Metabolic Disease
|
|
α-Amylase/α-Glucosidase-IN-18 (Compound 9g) is the inhibitor for α-Amylase and α-Glucosidase with IC50 of 49.17 nM and 10.71 nM. α-Amylase/α-Glucosidase-IN-18 can be used in research of type 2 diabetes mellitus [1].
|
-
- HY-172211
-
|
|
Amylases
Glycosidase
|
Metabolic Disease
Cancer
|
|
α-Amylase/α-Glucosidase-IN-17 (Compound 3) is an inhibitor of α-amylase and α-glucosidase, with IC50 values of 14.61 μM and 25.38 μM, respectively. α-Amylase/α-Glucosidase-IN-17 has certain inhibitory activity against A549 cancer cells. α-Amylase/α-Glucosidase-IN-17 has anti-tumor and anti-diabetic effects [1].
|
-
- HY-P3455
-
|
|
PGC-1α
|
Metabolic Disease
Cancer
|
|
Ac-SVVVRT-NH2 is a PGC-1α modulator that modulates the activity of the human PGC-1α promoter (114%). Ac-SVVVRT-NH2 increases PGC-1α mRNA (125%) and accumulation of intracellular lipids (128%) in subcutaneous human adipocytes. Ac-SVVVRT-NH2 can be used in the research of diseases which is modulated by PGC-1α .
|
-
- HY-101491
-
|
|
PGC-1α
Autophagy
|
Metabolic Disease
|
|
SR-18292 is a PPAR gamma coactivator-1α (PGC-1α) inhibitor, which increases PGC-1α acetylation, suppresses gluconeogenic gene expression and reduces glucose production in hepatocytes.
|
-
- HY-N9487
-
|
(-)-α-Phellandrene
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
(R)-(-)-α-Phellandrene ((-)-α-Phellandrene) is an the (R)-(-)-stereoisomer of α-phellandrene. α-phellandrene is an orally active cyclic monoterpene that attenuates inflammatory response, and induces DNA damage [1] .
|
-
- HY-121615
-
|
Alpha-Phellandrene
|
Insecticide
Apoptosis
Autophagy
NO Synthase
|
Infection
Neurological Disease
Inflammation/Immunology
Cancer
|
|
α-Phellandrene (alpha-Phellandrene) is an orally active monoterpenoid and insecticide. α-Phellandrene can be isolated from plant essential oils. α-Phellandrene induces Apoptosis and Autophagy. α-Phellandrene promotes cAMP signaling pathway and increases NO production. α-Phellandrene has anti-inflammatory and anticancer (sarcoma) activities. α-Phellandrene shows insecticidal activity against Lucilia cuprina L3. α-Phellandrene reduces mechanical hyperalgesia [1] .
|
-
- HY-N2853
-
|
α-Tocopherylquinone
|
Reactive Oxygen Species (ROS)
|
Others
|
|
D-α-Tocopherylquinone (α-Tocopherylquinone) is a quinone, can be isolated from Phaeodactylum tricornutum. D-α-Tocopherylquinone is an oxidation product of α-Tocopherol (vitamin E). D-α-Tocopherylquinone can act as an anticoagulant and as an antioxidant. D-α-Tocopherylquinone reduces cellular oxidative damage produced by oxidized lipids. D-α-Tocopherylquinone binds to a liver cytosolic protein with a molecular mass of about 40 kDa. D-α-Tocopherylquinone binds to glurathione-S-transferase (GST) and can be transported to the site of metabolism or excreted in the bile [1] .
|
-
- HY-162390
-
|
|
Amylases
Glycosidase
|
Endocrinology
|
|
α-Amylase/α-Glucosidase-IN-11 (Compound 5d) is a isoxazolidine-isatin hybrid with significant antidiabetic activity. α-Amylase/α-Glucosidase-IN-11 competitively inhibits α-amylase (IC50 = 30.39 μM) and α-glucosidase (IC50 = 65.1 μM), two key digestive enzymes. α-Amylase/α-Glucosidase-IN-11 does not cross the blood-brain barrier [1].
|
-
- HY-162169
-
|
|
Amylases
Glycosidase
|
Metabolic Disease
|
|
α-Amylase/α-Glucosidase-IN-8 (Compound 7p) is a potent dual inhibitor of α-amylase and α-glucosidase, with IC50s of 10.19 and 10.33 μM, respectively. α-Amylase/α-Glucosidase-IN-8 has good anti-oxidant activity(IC50 = 14.93 μM). α-Amylase/α-Glucosidase-IN-8 can be used for the research of diabetes [1].
|
-
- HY-103209
-
|
|
Adrenergic Receptor
|
Cardiovascular Disease
Endocrinology
|
|
Rec 15/2615 hydrochloride is a potent and selective α-1B adrenoceptor antagonist with Ki values of 1.9 nM, 0.3 nM, 2.6 nM for α1A, α1B, α1D, respectively. Rec 15/2615 hydrochloride modulates vaginal smooth muscle contractility and genital engorgement [1] .
|
-
- HY-161469
-
-
- HY-B0892S
-
-
- HY-155241
-
|
|
Glycosidase
Amylases
|
Metabolic Disease
|
|
α-Amylase/α-Glucosidase-IN-4 (compound 5) is a dual inhibitor of α-glucosidase (Glucosidase) and α-amylase (Amylases) with IC50s of 0.15 μM and 1.10 μM, respectively. α-Amylase/α-Glucosidase-IN-4 has potential antidiabetic activity [1].
|
-
- HY-149557
-
|
|
Glycosidase
Amylases
|
Metabolic Disease
|
|
α-Amylase/α-Glucosidase-IN-5 (compound 4l) is a dual inhibitor of α-glucosidase (Glucosidase) and α-amylase (Amylases) with IC50s of 5.96 μM and 1.62 μM, respectively. α-Amylase/α-Glucosidase-IN-4 has potential antidiabetic activity [1].
|
-
- HY-162673
-
|
|
Amylases
Glycosidase
|
Metabolic Disease
|
|
α-Amylase/α-Glucosidase-IN-16 (compound 15) is a potent dual inhibitor of α-amylase and α-Glucosidase with IC50 values of 0.8 and 1.2 μM, respectively. α-Amylase/α-Glucosidase-IN-16 can be used in the study of diabetes mellitus (DM) [1].
|
-
- HY-156380
-
|
|
Amylases
Glycosidase
|
Metabolic Disease
|
|
α-Amylase/α-Glucosidase-IN-6 (compound 5j) is a potent dual inhibitor of α-amylase and α-glucosidase, with IC50s of 17.0 and 40.1 µM, respectively. α-Amylase/α-Glucosidase-IN-6 exhibits anti-hyperglycemic activities [1].
|
-
- HY-154972
-
|
|
Glycosidase
Amylases
|
Metabolic Disease
|
|
α-Amylase/α-Glucosidase-IN-3 (Compound 17) is an α-Amylase/α-Glucosidase dual inhibitor, with IC50s of 0.70 μM and 1.10 μM. α-Amylase/α-Glucosidase-IN-3 can be used for research of type-II diabetes mellitus [1].
|
-
- HY-CE00053
-
|
(24R,25R)-3Alpha,7Alpha,12Alpha,24-Tetrahydroxy-5beta-cholestanoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
|
(24R,25R)-3Alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-cholestan-26-oyl-CoA ((24R,25R)-3Alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-cholestanoyl-coenzyme A) is an acyl-CoA.
|
-
- HY-133966
-
|
5α-Cholestane-3β,6α-diol
|
Reactive Oxygen Species (ROS)
|
Others
|
|
6α-Hydroxy-5α-cholestane (5α-Cholestane-3β,6α-diol) is an oxysterol that promotes the production of superoxide anions in SK-N-BE cells at concentrations of 50 μM and 100 μM [1].
|
-
- HY-CE00040
-
|
(24E)-3Alpha,7Alpha,12Alpha-trihydroxy-5beta-cholest-24-en-26-oyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
|
(24E)-3Alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA ((24E)-3Alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-coenzyme A) is a 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA.
|
-
- HY-N10564
-
|
|
P-glycoprotein
|
Cancer
|
|
8α,9α-Epoxycoleon-U-quinone (compound 3) is a p-glycoprotein (P-gp) regulator that is selective for cancer cells (SI=2.0). 8α,9α-Epoxycoleon-U-quinone effectively inhibits P-gp activity in NCI-H460/R cells. 8α,9α-Epoxycoleon-U-quinone also reverses the resistance of cancer cells to Doxorubicin (DOX) (HY-15142A) and enhances the anticancer effect of DOX [1].
|
-
- HY-129953
-
-
- HY-162036
-
|
|
Glycosidase
Amylases
Cholinesterase (ChE)
|
Neurological Disease
Metabolic Disease
|
|
α-Amylase/α-Glucosidase-IN-7 (Compound 3f) is a competitive α-glucosidase and α-amylase enzyme inhibitor with IC50 values of 18.52 and 20.25 µM, respectively. α-Amylase/α-Glucosidase-IN-7 can also effectively inhibit AChE and BChE, with IC50 values of 9.25 and 10.06 µM respectively. α-Amylase/α-Glucosidase-IN-7 can be used in diabetes and Alzheimer’s research [1].
|
-
- HY-N2514
-
|
α-D-Lactose
|
Others
|
Others
|
|
α-Lactose (α-D-Lactose) is the major sugar present in milk. Lactose exists in the form of two anomers, α and β. The α form normally crystallizes as a monohydrate [1] .
|
-
- HY-W127508
-
|
|
Biochemical Assay Reagents
|
Others
|
|
α,α'-Dilaurin is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-103204
-
|
|
Adrenergic Receptor
|
Endocrinology
|
|
RS100329 hydrochloride is a potent and selective α1A-adrenoceptor antagonist with pKi values of 9.6, 7.9 and 7.5 for α1A, α1D, and α1B, respectively. RS100329 hydrochloride inhibits reflex urethral contractions. RS100329 hydrochloride can be used in research of benign prostatic hyperplasia [1] .
|
-
- HY-130529
-
|
OH-α-Pyrrolidinovalerophenone TFA
|
Endogenous Metabolite
|
Metabolic Disease
|
|
OH-α-PVP (OH-α-Pyrrolidinovalerophenone ) TFA is a metabolite of α-pyrrolidinovalerophenone. α-pyrrolidinovalerophenone is a synthetic stimulant of the cathinone class [1] .
|
-
- HY-170056
-
-
- HY-172622
-
-
- HY-P9970A
-
|
Avakine (Anti-TNF-α); CT-P13 (Anti-TNF-α)
|
TNF Receptor
|
Neurological Disease
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
Infliximab (Anti-TNF-α) (Avakine (Anti-TNF-α)) is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α. Infliximab (Anti-TNF-α) prevents the interaction of TNF-α with TNF-α receptor (TNFR1 and TNFR2). Infliximab (Anti-TNF-α) has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research [1] .
|
-
- HY-W399297
-
|
7α,12α-Dihydroxycholanoic acid
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Isodeoxycholic acid (7α,12α-Dihydroxycholanoic acid) is the 3β-epimer of ursodeoxycholic acid. Isodeoxycholic acid has the effect on choleresis and liver biochemistry [1].
|
-
- HY-145480
-
|
Silodosin β-D-glucuronide sodium
|
Drug Metabolite
|
Others
|
|
Silodosin Glucuronide sodium (Silodosin β-D-glucuronide sodium) is the metabolite of Silodosin (HY-10122). Silodosin is a selective and orally active antagonist for α1A-adrenergic receptor (α1A-AR) with Ki of 0.036 nM [1].
|
-
- HY-P5859
-
|
α-PMTX
|
Biochemical Assay Reagents
|
Neurological Disease
|
|
α-Pompilidotoxin (α-PMTX) is a neurotoxin that can be obtained from the venom of Anoplius safnariensis. α-Pompilidotoxin reversibly and dose-dependently enhances excitatory postsynaptic currents (EPSCs). α-Pompilidotoxin is a useful tool in the field of neuroscience research [1].
|
-
- HY-N1467
-
|
(S)-α-Terpineol
|
Others
|
Others
|
|
(-)-α-Terpineol ((S)-α-Terpineol), a monoterpene compound, is one of compounds in Melaleuca alternifolia. (-)-α-Terpineol has antioxidant and anti-inflammatory activities [1] .
|
-
- HY-B0484R
-
|
|
Reference Standards
Adrenergic Receptor
|
Cardiovascular Disease
|
|
Buflomedil hydrochloride (Standard) is the analytical standard of Buflomedil hydrochloride (HY-B0484). This product is intended for research and analytical applications. Buflomedil hydrochloride (Standard), a vasodilator agent, is an orally active α1A-adrenoceptor antagonist with Kis of 4.06 µM and 6.84 µM for α1A-AR and α1B-AR, respectively. Buflomedil hydrochloride can be used for the study of peripheral circulatory disorders [1] .
|
-
- HY-162634
-
|
|
Amylases
Glycosidase
|
Metabolic Disease
|
|
α-Amylase/α-Glucosidase-IN-15 (compound 6C) is an oral bioactive inhibitor of α-Glucosidase and α-amylase, with the IC50s of 21 μM and 61 μM, respectively [1].
|
-
- HY-N0611
-
|
α-Boswellic acid
|
Others
|
Neurological Disease
Inflammation/Immunology
Cancer
|
|
alpha-Boswellic acid (α-Boswellic acid) is an orally active pentacyclic triterpenoid compound that can be extracted from frankincense. alpha-Boswellic acid has anti-inflammatory and antitumor activities. alpha-Boswellic acid can be used in Alzheimer's disease (AD) research [1] .
|
-
- HY-N8459
-
|
α-CBD
|
EBV
|
Cancer
|
|
α-Cembrenediol is a potent inhibitor of EBV.α-Cembrenediol inhibits the early antigen of the Epstein-Bar virus. α-Cembrenediol also has anti-tumour activity [1].
|
-
- HY-133966S
-
-
- HY-N9960
-
-
- HY-161355
-
|
|
Amylases
Glycosidase
|
Metabolic Disease
|
|
α-Amylase/α-Glucosidase-IN-9 (compound 5h) is a dual inhibitor for both α-amylase (IC50 = 16.4 μM) and α-glucosidase (IC50 = 31.6 μM) enzymes [1].
|
-
- HY-162373
-
|
|
Amylases
Glycosidase
P-glycoprotein
|
Metabolic Disease
|
|
α-Amylase/α-Glucosidase-IN-10 (compound 5d) is an α-amylase and α-glucosidase inhibitor (IC50: 30.39 μM and 65.1 μM) with potential diabetes inhibitory effects. α-Amylase/α-Glucosidase-IN-10 exhibits high gastrointestinal (GI) absorption in ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) prediction. While α-Amylase/α-Glucosidase-IN-10 acts as a substrate for P-gp and does not cross the blood-brain barrier (BBB), there may be a risk of central nervous system side effects [1].
|
-
- HY-N2766
-
|
|
Others
|
Others
|
|
8alpha-Hydroxy-alpha-gurjunene is a Sesquiterpenoids product that can be isolated from the herbs of Sarcandra glabra [1].
|
-
- HY-118459
-
-
- HY-N2853R
-
|
α-Tocopherylquinone (Standard)
|
Reference Standards
Reactive Oxygen Species (ROS)
|
Others
|
|
D-α-Tocopherylquinone (α-Tocopherylquinone) (Standard) is the analytical standard of D-α-Tocopherylquinone. This product is intended for research and analytical applications. D-α-Tocopherylquinone is a quinone, can be isolated from Phaeodactylum tricornutum. D-α-Tocopherylquinone is an oxidation product of α-Tocopherol (vitamin E). D-α-Tocopherylquinone can act as an anticoagulant and as an antioxidant. D-α-Tocopherylquinone reduces cellular oxidative damage produced by oxidized lipids. D-α-Tocopherylquinone binds to a liver cytosolic protein with a molecular mass of about 40 kDa. D-α-Tocopherylquinone binds to glurathione-S-transferase (GST) and can be transported to the site of metabolism or excreted in the bile [1] .
|
-
- HY-19667
-
|
DPC 333
|
TNF Receptor
|
Inflammation/Immunology
|
|
BMS-561392 is a TNF alpha-converting enzyme (TACE) inhibitor. BMS-561392 is also an ADAM17 blocker. BMS-561392 can be used for research of inflammatory bowel disease [1] .
|
-
- HY-CE00074
-
|
(25S)-THCA-Coenzyme A
|
Biochemical Assay Reagents
|
Others
|
|
(25S)-3Alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA ((25S)-THCA-Coenzyme A) is a 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA.
|
-
- HY-162635
-
|
|
Amylases
Glycosidase
|
Metabolic Disease
|
|
α-Amylase/α-Glucosidase-IN-14 (compound 6E) is an oral bioactive inhibitor of α-amylase and α-glucosidase, with the IC50s of 45.53 μM and 27.73 μM, respectively [1].
|
-
- HY-163439
-
|
|
Amylases
Glycosidase
|
Metabolic Disease
|
|
α-Amylase/α-Glucosidase-IN-12 (compound 10k) is a dual inhibitor targeting α-glucosidase and α-amylase with IC50 of 34.52 nM and 24.62 nM, respectively. α-Amylase/α-Glucosidase-IN-12 is an inhibitor designed based on triazolo[4,3-b][1,2,4]triazine and has the potential to be used in diabetes research [1].
|
-
- HY-N9960R
-
|
α-IPM (Standard)
|
Reference Standards
Others
|
Others
|
|
α-Isopropylmalate (Standard) is the analytical standard of α-Isopropylmalate. This product is intended for research and analytical applications. α-Isopropylmalate (α-IPM) is the leucine biosynthetic precursor in Yeast [1].
|
-
- HY-N9083
-
|
|
Others
|
Others
|
|
8α-Hydroxy-α-gurjunene is a Flavonoids product that can be isolated from the aerial parts of Sophora tomentosa L. [1].
|
-
- HY-W087904
-
|
α-D-Lactose hydrate
|
Endogenous Metabolite
|
Others
|
|
α-Lactose (hydrate) (α-D-Lactose (hydrate)) is the principal carbohydrate in the milk of most mammals. α-Lactose (hydrate) consists of glucose and galactose and exists in the form of two anomers, α and β. α-Lactose (hydrate) has many uses in the food and pharmaceutical industries, such as a free-flowing or agglomerating agent, a diluent for pigments, flavors, or enzymes [1] .
|
-
- HY-N8847
-
|
Alpha-Ionone
|
Hippo (MST)
YAP
Olfactory Receptor
Apoptosis
|
Cancer
|
|
α-Ionone (alpha-Ionone) is an activator of the olfactory receptor OR10A6. α-Ionone induces apoptosis by activating OR10A6 and increasing the phosphorylation of the LATS-YAP-TAZ signaling axis in the Hippo pathway. α-Ionone can inhibit tumor formation both in vivo and in vitro [1].
|
-
- HY-N0683
-
-
- HY-N0611R
-
|
α-Boswellic acid (Standard)
|
Reference Standards
Others
|
Neurological Disease
Inflammation/Immunology
Cancer
|
|
alpha-Boswellic acid (Standard) is the analytical standard of alpha-Boswellic acid. This product is intended for research and analytical applications. alpha-Boswellic acid (α-Boswellic acid) is an orally active pentacyclic triterpenoid compound that can be extracted from frankincense. alpha-Boswellic acid has anti-inflammatory and antitumor activities. alpha-Boswellic acid can be used in Alzheimer's disease (AD) research [1] .
|
-
- HY-17538S
-
|
|
PGC-1α
Autophagy
|
Metabolic Disease
|
|
ZLN005-d4 is deuterium labeled ZLN005. ZLN005 is a potent activator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) .
|
-
- HY-N0683R
-
-
- HY-12519
-
|
RP 35972; NSC 347901
|
HIF/HIF Prolyl-Hydroxylase
HIV
Keap1-Nrf2
Parasite
|
Cancer
|
|
Oltipraz has an inhibitory effect on HIF-1α activation in a time-dependent manner, completely abrogating HIF-1α induction at ≥10 μM concentrations, the IC50 of Oltipraz for HIF-1α inhibition is 10 μM. Oltipraz is a potent Nrf2 activator.
|
-
- HY-110266
-
GN44028
5 Publications Verification
|
HIF/HIF Prolyl-Hydroxylase
|
Cancer
|
|
GN44028 is a potent and orally active hypoxia inducible factor (HIF)-1α inhibitor, with an IC50 of 14 nM. GN44028 inhibits hypoxia-induced HIF-1α transcriptional activity without suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization. GN44028 can be used in the research of cancers [1] .
|
-
- HY-123712
-
-
- HY-N1720
-
|
|
Others
|
Others
|
|
2α,3α,24-Trihydroxyolean-12-en-28-oic acid (compound 5) is a terpenoid that is isolated from the branches and leaves of Pyrus pashia. 2α,3α,24-Trihydroxyolean-12-en-28-oic acid shows cytotoxic activity [1].
|
-
- HY-133890A
-
|
T-α-MCA sodium
|
Endogenous Metabolite
FXR
|
Others
|
|
Tauro-α-muricholic acid (T-α-MCA) sodium is a FXR (Farnesoid X receptor) antagonist (IC50=28μM). Tauro-α-muricholic acid sodium is also a endogenous metabolite that can be found in cecal [1] .
|
-
- HY-133890
-
|
T-α-MCA
|
Endogenous Metabolite
FXR
|
Cardiovascular Disease
Others
Metabolic Disease
|
|
Tauro-alpha-muricholic acid (T-alpha-MCA) is a bile acid that belongs to a class of compounds that are synthesized in the liver and play an important role in the digestive process. Tauro-α-muricholic acid activates Farni X receptors (FXR) which are involved in the regulation of bile acid synthesis, metabolism and transport. Tauro-alpha-muricholic acid can be used in the study of metabolic syndrome and cardiovascular disease [1].
|
-
- HY-123076
-
|
PFN-α
|
MDM-2/p53
|
Neurological Disease
|
|
Pifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form p53 inhibitor. Pifithrin-α, p-Nitro, Cyclic is one order magnitude more active than Pifithrin-α in protecting cortical neurons exposed to Etoposide (ED50=30 nM). Pifithrin-α, p-Nitro, Cyclic behaves as a p53 posttranscriptional activity inhibitor. Pifithrin-α, p-Nitro, Cyclic do not prevent p53 phosphorylation on the S15 residue [1] .
|
-
- HY-12749
-
-
- HY-P3976
-
|
|
Angiotensin-converting Enzyme (ACE)
|
Cardiovascular Disease
|
|
Lactalbumin B (50-53) Alpha [Lactorphin Alpha], bovine is a blood pressure lowering peptide containing 4 amino acids. Lactalbumin B (50-53) Alpha [Lactorphin Alpha], bovine is an angiotensin-converting Enzyme (ACE) inhibitor. Lactalbumin B (50-53) Alpha [Lactorphin Alpha], bovine can be used in research of high blood pressure [1].
|
-
![Lactalbumin B (50-53) Alpha [Lactorphin Alpha], bovine](//file.medchemexpress.com/product_pic/hy-p3976.gif)
- HY-118335S
-
|
SZL 49-d8
|
Isotope-Labeled Compounds
Adrenergic Receptor
|
Cardiovascular Disease
|
|
Prazobind-d8 is the deuterium labeled Prazobind (HY-118335). Prazobind (SZL 49), a prazosin analog, is a selective α1-adrenoceptor antagonist. Prazobind competes for alpha 1-adrenoceptor binding sites with a similar potency (IC50 of 1 nM) in tissues enriched in both the alpha 1A (hippocampus) and alpha 1B (liver) subtypes. Prazobind can be used for the study of blood pressure [1] .
|
-
- HY-N11598
-
|
|
Others
|
Metabolic Disease
|
|
α-GLU stands for α-glucosidase. α-GLU hydrolyzes starch and disaccharides via targeting to terminal, non-reducing (1→4)-linked α-D-glucose residues to produce α-glucose. α-GLU is substrate selective [1].
|
-
- HY-N8847R
-
|
Alpha-Ionone (Standard)
|
Reference Standards
Hippo (MST)
YAP
|
Cancer
|
|
α-Ionone (Standard) is the analytical standard of α-Ionone. This product is intended for research and analytical applications. α-Ionone (alpha-Ionone) is an activator of the olfactory receptor OR10A6. α-Ionone induces apoptosis by activating OR10A6 and increasing the phosphorylation of the LATS-YAP-TAZ signaling axis in the Hippo pathway. α-Ionone can inhibit tumor formation both in vivo and in vitro [1].
|
-
- HY-W087904R
-
|
α-D-Lactose hydrate (Standard)
|
Endogenous Metabolite
Reference Standards
|
Others
|
|
α-Lactose (hydrate) (Standard) is the analytical standard of α-Lactose (hydrate). This product is intended for research and analytical applications. α-Lactose (hydrate) (α-D-Lactose (hydrate)) is the principal carbohydrate in the milk of most mammals. α-Lactose (hydrate) consists of glucose and galactose and exists in the form of two anomers, α and β. α-Lactose (hydrate) has many uses in the food and pharmaceutical industries, such as a free-flowing or agglomerating agent, a diluent for pigments, flavors, or enzymes [1] .
|
-
- HY-111387
-
-
- HY-115854
-
|
|
GABA Receptor
|
Neurological Disease
|
|
Ro 15-1310 is an imidazobenzodiazepine that exhibits high affinity and selectivity for alpha 5-containing GABAA receptors. Ro 15-1310 is promising for research of convulsions [1].
|
-
- HY-W039849
-
|
Ethyl α-thioglucopyranoside
|
Biochemical Assay Reagents
|
Others
|
|
Ethyl-α-D-thioglucopyranoside (Ethyl α-Thioglucopyranoside) is a glycoside present in sake, Japanese rice wine. Ethyl-α-D-thioglucopyranoside is a glycosyl donor [1].
|
-
- HY-N10330
-
|
|
HIF/HIF Prolyl-Hydroxylase
VEGFR
|
Cancer
|
|
7-Hydroxyneolamellarin A is a natural product that could be derived from sponge Dendrilla nigra. 7-Hydroxyneolamellarin A is a potent hypoxia-inducible factor-1α (HIF-1α) inhibitor. 7-Hydroxyneolamellarin A attenuates the accumulation of hypoxia-inducible factor-1α (HIF-1α) protein and inhibits vascular epidermal growth factor (VEGF) transcriptional activity. 7-Hydroxyneolamellarin A can be used in research of cancer [1].
|
-
- HY-167584S
-
-
- HY-B0769
-
-
- HY-12749A
-
-
- HY-P99447
-
|
|
Bacterial
|
Infection
|
|
Atidortoxumab is a human IgG1κ monoclonal antibody that targets Staph aureus alpha toxin [1].
|
-
- HY-129764
-
|
PGF3α
|
P-glycoprotein
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
Prostaglandin F3α (PGF3α) is an eicosapentaenoic acid (EPA)-derived bioactive lipid mediator that has anti-cancer and anti-inflammatory effects. Prostaglandin F3α is a substrate of ABCC4 with a Km of 12.1 μM. Prostaglandin F3α can be used for the research of diabetes [1] .
|
-
- HY-W650803
-
|
A-57219
|
Adrenergic Receptor
|
Cardiovascular Disease
|
|
Nemazoline (A-57219) is selective α-adrenergic agent with α1-agonist/α2-antagonist activity, which is used as a nasal decongestant. Nemazoline produces decongestion by α1-mediated contraction of capacitance vessels, but not compromises blood flow by virtue of α2-antagonism. Nemazoline also blocks endogenous noradrenaline-mediated α 2-constriction of the resistance vessels [1].
|
-
- HY-B0371D
-
|
|
Adrenergic Receptor
|
Endocrinology
|
|
(S)-Terazosin is an active S-enantiomer of Terazosin. (S)-Terazosin is a potent and high-affinity α-adrenoceptor antagonist with Ki values of 3.91 nM, 0.79 nM and 1.16 nM for α1a, α1b and α1d-adrenoceptor, respectively. (S)-Terazosin also has high-affinity for α2a, α2B and α2c-adrenoceptor with Ki values of 729 nM, 3.5 nM and 46.4 nM, respectively [1].
|
-
- HY-111188
-
|
|
Adrenergic Receptor
|
Others
|
|
A55453 is a prazosin analogue and a potent α1-adrenergic antagonist. 125I-A55453 is a high-affinity alpha 1-adrenergic receptor probe [1].
|
-
- HY-W020044R
-
|
DL-α-Tocopherol (Standard)
|
Reference Standards
Ferroptosis
DNA/RNA Synthesis
Apoptosis
|
Cancer
|
|
DL-alpha-Tocopherol (Standard) is the analytical standard of DL-alpha-Tocopherol. This product is intended for research and analytical applications. DL-alpha-Tocopherol is a synthetic vitamin E, with antioxidation effect. DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB [1].
|
-
- HY-129953B
-
|
15(R)-PGF2α
|
Endogenous Metabolite
|
Inflammation/Immunology
|
|
15(R)-Prostaglandin F2α is the isomer of 9α,11β-Prostaglandin F2α (HY-129953). 9α,11β-Prostaglandin F2α is an endogenous metabolite present in Urine that can be used for the research of Asthma [1] .
|
-
- HY-W342092
-
|
|
Biochemical Assay Reagents
Endogenous Metabolite
|
|
|
1,3,4,6-Tetrachloro-3α,6α-diphenylglycouril is a chemical agent that has the property of inhibiting enzyme activity in organisms. 1,3,4,6-Tetrachloro-3α,6α-diphenylglycouril is used as a potential anti-tumor agent in compound development. 1,3,4,6-Tetrachloro-3α,6α-diphenylglycouril has the effect of regulating cell signaling pathways and can be used to study cell biology. 1,3,4,6-Tetrachloro-3α,6α-diphenylglycouril is considered to be a potent compound that can exert biological activity under specific conditions.
|
-
- HY-170045
-
-
- HY-150536
-
|
|
HIV
HIV Protease
|
Infection
|
|
EP39 is a potent HIV-1 maturation inhibitor. EP39 interacts with the SP1 domain of Gag. EP39 decreases the dynamics of CA-SP1 junction, by binding to the QVT motif of the SP1 domain, and perturbs the natural coil-helix equilibrium on both sides of the SP1 domain by stabilizing the transient alpha helical structure. EP39 acts by arresting maturation of HIV-1 thereby blocking its infectivity [1].
|
-
- HY-P2707
-
|
α-DTX
|
Sodium Channel
Potassium Channel
|
Others
|
|
α-Dendrotoxin (α-DTX) is a small molecule peptide neurotoxin isolated from the venom of the African green mamba snake (Dendroaspis angusticeps). α-Dendrotoxin is also a KV1.1, KV1.2, KV1.6 and ASIC channel blocker. α-Dendrotoxin blocks potassium channels, lowers the threshold of neuronal action potentials, and increases the frequency of action potentials, thereby enhancing neuronal excitability. α-Dendrotoxin can be used in neurotoxicology research [1].
|
-
- HY-116549
-
|
PGF2α alcohol
|
Prostaglandin Receptor
|
Inflammation/Immunology
|
|
Prostaglandin F2α alcohol (PGF2α alcohol) is an analog of PGF2α. Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist [1].
|
-
- HY-119418
-
|
|
Estrogen Receptor/ERR
|
Cancer
|
|
Desketoraloxifene is an estrogen receptors alpha (ERα) activator at an AP-1 site. Desketoraloxifene can be used for the research of osteoporosis and breast cancer [1].
|
-
- HY-170050
-
-
- HY-W587800
-
-
- HY-123489
-
|
THDOC
|
GABA Receptor
|
Neurological Disease
|
|
3α,21-Dihydroxy-5α-pregnan-20-one (THDOC), an endogenous neurosteroid, is a positive modulator of GABAA receptors. 3α,21-Dihydroxy-5α-pregnan-20-one potentiates neuronal response to low concentrations of GABA at α4β1δ GABAA receptors in vitro.
|
-
- HY-N0710R
-
|
α-Cyperone (Standard); (+)-α-Cyperone (Standard)
|
Reference Standards
Endogenous Metabolite
|
Inflammation/Immunology
|
|
alpha-Cyperone (Standard) is the analytical standard of alpha-Cyperone. This product is intended for research and analytical applications. alpha-Cyperone (α-Cyperone) is associated with the down-regulation of COX-2, IL-6, Nck-2, Cdc42 and Rac1, resulting in reduction of inflammation, which would be highly beneficial for treatment of inflammatory diseases such as AD.
|
-
- HY-W677042
-
|
5α-Androst-16-en-3α-ol
|
GABA Receptor
|
Neurological Disease
|
|
α-Androstenol (5α-Androst-16-en-3α-ol) is a steroid pheromone that has been found in boar testes and human male axillary sweat. α-Androstenol is also a positive modulator of GABAA receptors, which enhances GABA-activated currents in primary mouse cerebellar granule cells (EC50=0.4 μM). α-Androstenol decreases immobility time in the forced swim test and increases time spent in the open arms of the elevated plus maze in mice. α-Androstenol protects against seizures induced by Pentylenetetrazole or electroshock with anxiolytic-like activity in mice [1] .
|
-
- HY-W009027
-
-
- HY-127144
-
|
α-Dihydrosaxitoxin
|
Drug Derivative
|
Neurological Disease
|
|
α-Saxitoxinol is an epimer of Dihydtosaxitoxin and a derivative of saxitoxin. α-Saxitoxinol represents approximately 3.7% of the biological activity of Saxitoxin (a neurotoxin) [1].
|
-
- HY-W127431
-
|
5α-Cholanic acid-3α-ol-6-one 3-acetate methyl ester
|
Biochemical Assay Reagents
|
Others
|
|
Methyl (3α,5α)-3-(acetyloxy)-6-oxocholan-24-oate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W726076
-
|
|
Biochemical Assay Reagents
|
Others
|
|
3α,6α-Mannopentaose is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology [1].
|
-
- HY-P2802
-
|
α-D-Glucosidase, Yeast
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase, Yeast (α-D-Glucosidase, Yeast), a carbohydrate hydrolyzing enzyme, catalyzes the liberation of α-glucose from the non-reducing end of the substrate. α-Glucosidase can facilitate the absorption of glucose by the small intestine. Inhibition of α-Glucosidase is an effective management of non-insulin-dependent diabetes mellitus (NIDDM) [1] .
|
-
- HY-149331
-
|
|
TNF Receptor
Caspase
NF-κB
|
Inflammation/Immunology
|
|
TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor with a KD value of 12.06 μM. TNF-α-IN-11 binds to TNF-α and blocks the activation of TNF-α-trigged caspase and NF-κB signaling pathway. TNF-α-IN-11 inhibits the phosphorylation of IκBα, as well as the nuclear translocation of NF κB p65. TNF-α-IN-11 can be used for research of TNF-α-mediated autoimmune diseases [1].
|
-
- HY-W039911
-
|
PNP-Alpha-D-Gal; PNP-α-D-Gal
|
Biochemical Assay Reagents
|
Others
|
|
4-Nitrophenyl α-D-galactopyranoside (PNP-alpha-D-Gal) is an artificial substrate of 4-nitrophenyl (pNP) glycopyranoside for detecting α-galactosidase activity. The amount of released pNP is significantly increased when 4-Nitrophenyl α-D-galactopyranoside is used as substrates [1].
|
-
- HY-W020044
-
|
DL-α-Tocopherol
|
Ferroptosis
DNA/RNA Synthesis
Apoptosis
|
Cancer
|
|
DL-alpha-Tocopherol is a synthetic vitamin E, with antioxidation effect. DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB [1].
|
-
- HY-160436
-
-
- HY-Y0149S
-
-
- HY-134420
-
-
- HY-B0098A
-
-
- HY-12760
-
-
- HY-B0098
-
-
- HY-12519S
-
|
RP 35972-d3; NSC 347901-d3
|
Isotope-Labeled Compounds
HIF/HIF Prolyl-Hydroxylase
HIV
Keap1-Nrf2
|
Cancer
|
|
Oltipraz-d3 is the deuterium labeled Oltipraz. Oltipraz has an inhibitory effect on HIF-1α activation in a time-dependent manner, completely abrogating HIF-1α induction at ≥10 μM concentrations, the IC50 of Oltipraz for HIF-1α inhibition is 10 μM. Oltipraz is a potent Nrf2 activator.
|
-
- HY-N0683A
-
-
- HY-P1264
-
|
|
nAChR
|
Neurological Disease
|
|
α-Bungarotoxin is a competitive antagonist at nicotinic acetylcholine receptors (nAChRs). α-Bungarotoxin, a selective α7 receptor blocker, blocks α7 currents with an IC50 of 1.6 nM and has no effects on α3β4 currents at concentrations up to 3 μM [1] .
|
-
- HY-B0354A
-
-
- HY-118710
-
-
- HY-116757
-
-
- HY-164293
-
-
- HY-102022
-
|
α-GalCer; KRN7000
|
Transmembrane Glycoprotein
Interleukin Related
CD1
|
Inflammation/Immunology
Cancer
|
|
α-Galactosylceramide (α-GalCer) is a synthetic glycolipid with antitumorial and immunostimulatory. α-Galactosylceramide is a very potent NKT cell agonist and binds effectively to CD1d. The complex of α-Galactosylceramide plus CD1d binds the NKT cell TCR (T cell antigen receptor) [1] .
|
-
- HY-N2018
-
|
α-D-Xylopyranose
|
Endogenous Metabolite
|
Metabolic Disease
|
|
α-D-Xylose (α-D-Xylopyranose) is a basic component of the five-carbon fraction of biomass and a precursor of hemicellulose. α-D-Xylose participates in a variety of enzyme-catalyzed reactions, which in turn participate in a variety of metabolic pathways. In addition, α-D-Xylose is also used in tanning, dyeing and as a diabetic food [1].
|
-
- HY-N0255R
-
|
α-Hederin (Standard)
|
Reference Standards
Apoptosis
|
Others
|
|
alpha-Hederin (Standard) is the analytical standard of alpha-Hederin. This product is intended for research and analytical applications. alpha-Hederin (α-Hederin), a monodesmosidic triterpenoid saponin, exhibits promising antitumor potential against a variety of human cancer cell lines. alpha-Hederin could inhibit the proliferation and induce apoptosis of gastric cancer accompanied by glutathione decrement and reactive oxygen species generation via activating mitochondrial dependent pathway [1].
|
-
- HY-P2901
-
|
3α-HSD
|
Endogenous Metabolite
|
Endocrinology
|
|
3α-Hydroxysteroid Dehydrogenase, Microorganism (3α-HSD) is an enzyme encoded by the AKR1C4 gene, which can catalyze the conversion of 3-ketosteroids into 3α-hydroxy compounds. 3α-Hydroxysteroid dehydrogenase plays an important role in the inactivation of androgen DHT, and can convert DHT into 3α-androstanediol with weak androgen activity, which can be used in the research of hirsutism [1].
|
-
- HY-E70104
-
|
α-L-Rhamnosidase
|
Glycosidase
|
Others
|
|
α-Rhamnosidase is a glycoside hydrolase. α-Rhamnosidase is able to finish the enzymatic de-glycosylation of many nature flavone glycosides [1].
|
-
- HY-15746A
-
|
|
Adrenergic Receptor
|
Cardiovascular Disease
Endocrinology
Cancer
|
|
Dobutamine is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine can increase cardiac output and correct hypoperfusion [1] .
|
-
- HY-15746
-
|
|
Adrenergic Receptor
|
Cardiovascular Disease
Endocrinology
Cancer
|
|
Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion [1] .
|
-
- HY-118135
-
|
4MU-α-Gal
|
Fluorescent Dye
|
Others
|
|
4-Methylumbelliferyl-α-D-galactopyranoside (4MU-α-Gal), a substrate for α-galactosidase A (GLA), is a blue pro-fluorogenic substrate. 4-Methylumbelliferyl-α-D-galactopyranoside forms two products, galactose and fluorescent 4MU, upon cleavage by GLA [1].
|
-
- HY-164997
-
|
15-keto PGF1α
|
Endogenous Metabolite
|
Metabolic Disease
|
|
15-keto Prostaglandin F1α (15-keto PGF1α) is a prostaglandin F1α metabolite. 15-keto Prostaglandin F1α (15-keto PGF1α) is an effective substrate for PGR-2. 15-keto Prostaglandin F1α (15-keto PGF1α) can be used to study physiological processes such as prostaglandin metabolism and lipogenesis [1].
|
-
- HY-N0700
-
|
α-Asarone; trans-Asarone
|
GABA Receptor
|
Neurological Disease
|
|
alpha-Asarone (α-Asarone) is one of the main psychoactive compounds, and possesses an antidepressant-like activity in mice.
|
-
- HY-W142080
-
|
α-Methyltryptophan
|
mTOR
Autophagy
Apoptosis
Amino Acid Derivatives
|
Metabolic Disease
Cancer
|
|
α-Methyl-DL-tryptophan (α-Methyltryptophan), a tryptophan derivative, is a selective SLC6A14 blocker. In estrogen receptor (ER)-positive breast cancer cells, α-Methyl-DL-tryptophan inhibits mTOR and activates autophagy and apoptosis. α-Methyl-DL-tryptophan also has the effect of reducing weight [1] .
|
-
- HY-N8908
-
|
|
Others
|
Infection
|
|
2α,9α,11-Trihydroxy-6-oxodrim-7-ene is a natural product that can be isolated from the culture medium of the marine-derived fungus Aspergillus insuetus [1].
|
-
- HY-160433
-
-
- HY-N9699
-
|
|
NF-κB
|
Inflammation/Immunology
|
|
8α-Hydroxyhirsutinolide is a sesquiterpene lactone. 8α-Hydroxyhirsutinolide inhibits TNF-α-induced NF-κB activity (IC50: 1.9 μM) and NO production. 8α-Hydroxyhirsutinolide can be isolated from Vernonia cinerea [1].
|
-
- HY-112074A
-
|
HOE 440 hydrochloride
|
Adrenergic Receptor
|
Cardiovascular Disease
|
|
Tiamenidine hydrochloride (HOE 440 hydrochloride) is a centrally acting α1-adrenergic receptor antagonist with hypotensive activity. Tiamenidine hydrochloride regulates blood pressure levels by binding to α1 receptors. Tiamenidine hydrochloride can be used in the study of hypertension [1].
|
-
- HY-N8745
-
|
|
Fungal
|
Others
|
|
α-Peltatin is an aryl lignan. α-Peltatin has anticancer and antifungal activity. α-Peltatin inhibits DNA topoisomerase and tubulin polymerization [1].
|
-
- HY-113962
-
|
7α,25-OHC
|
EBI2/GPR183
Endogenous Metabolite
|
Inflammation/Immunology
|
|
7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells [1] .
|
-
- HY-N0255
-
|
α-Hederin
|
Apoptosis
|
Others
Cancer
|
|
alpha-Hederin (α-Hederin), a monodesmosidic triterpenoid saponin, exhibits promising antitumor potential against a variety of human cancer cell lines. alpha-Hederin could inhibit the proliferation and induce apoptosis of gastric cancer accompanied by glutathione decrement and reactive oxygen species generation via activating mitochondrial dependent pathway [1].
|
-
- HY-105798
-
-
- HY-U00237
-
-
- HY-101491S
-
|
|
Isotope-Labeled Compounds
PGC-1α
Autophagy
|
Metabolic Disease
|
|
SR-18292-d9 is the deuterium labeled SR-18292 (HY-101491). SR-18292 is a PPAR gamma coactivator-1α (PGC-1α) inhibitor, which increases PGC-1α acetylation, suppresses gluconeogenic gene expression and reduces glucose production in hepatocytes [1].
|
-
- HY-12519R
-
|
|
HIF/HIF Prolyl-Hydroxylase
HIV
Keap1-Nrf2
Parasite
|
Cancer
|
|
Oltipraz (Standard) is the analytical standard of Oltipraz. This product is intended for research and analytical applications. Oltipraz has an inhibitory effect on HIF-1α activation in a time-dependent manner, completely abrogating HIF-1α induction at ≥10 μM concentrations, the IC50 of Oltipraz for HIF-1α inhibition is 10 μM. Oltipraz is a potent Nrf2 activator.
|
-
- HY-101337
-
-
- HY-B1513
-
|
|
Microtubule/Tubulin
SARS-CoV
|
Infection
Metabolic Disease
Cancer
|
|
α-Cyclodextrin (α-CD) is a soluble fiber derived from corn. α-Cyclodextrin can deplete sphingolipids and phospholipids from cell membranes. α-Cyclodextrin interacts with tubulin. α-Cyclodextrin improves defenses against SARS-CoV-2 infection. α-Cyclodextrin enhances the anticancer efficacy of Crcumin (HY-N0005) against breast, lung and cervical cancer. α-Cyclodextrin has beneficial effects on body weight and blood lipids [1] .
|
-
- HY-W739491
-
-
- HY-N0700R
-
|
α-Asarone (Standard); trans-Asarone (Standard)
|
Reference Standards
GABA Receptor
|
Neurological Disease
|
|
alpha-Asarone (Standard) is the analytical standard of alpha-Asarone. This product is intended for research and analytical applications. alpha-Asarone (α-Asarone) is one of the main psychoactive compounds, and possesses an antidepressant-like activity in mice.
|
-
- HY-118648
-
|
PGF2α methyl ester; Dinoprost methyl
|
Prostaglandin Receptor
|
Others
|
|
Prostaglandin F2α methyl ester (PGF2α methyl ester; Dinoprost methyl) is a PGF2α analog with more lipid solubility. Prostaglandin F2α methyl ester exhibits efficacy in maintaining the ocular hypotensive [1].
|
-
- HY-N0492
-
|
Thioctic acid; (±)-α-Lipoic acid; DL-α-Lipoic acid
|
NF-κB
HIV
Mitochondrial Metabolism
Endogenous Metabolite
Apoptosis
|
Infection
Inflammation/Immunology
Cancer
|
|
α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation [1] . α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .
|
-
- HY-N0492A
-
|
Thioctic acid sodium; (±)-α-Lipoic acid sodium; DL-α-Lipoic acid sodium
|
NF-κB
HIV
Mitochondrial Metabolism
Endogenous Metabolite
Apoptosis
|
Infection
Inflammation/Immunology
Cancer
|
|
α-Lipoic Acid (Thioctic acid) sodium is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid sodium inhibits NF-κB-dependent HIV-1 LTR activation [1] . α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid sodium can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .
|
-
- HY-W743870
-
|
|
Endogenous Metabolite
|
Neurological Disease
|
|
5α-Dihydrodeoxycorticosterone is an intermediate product of Deoxycorticosterone (HY-113414) catalyzed by 5α-reductase. 5α-Dihydrodeoxycorticosteron levels associated with depression [1].
|
-
- HY-113269
-
|
|
Drug Metabolite
|
Others
|
|
alpha-CEHC is a water-soluble metabolite of alpha-tocopherol (α-TOH) with potential antioxidant activity. alpha-CEHC slightly inhibits macrophage-induced low-density lipoprotein (LDL) oxidation, and its inhibitory potency is concentration-dependent [1] .
|
-
- HY-116051
-
|
16,16-Dimethyl-PGF2α
|
Prostaglandin Receptor
|
Cardiovascular Disease
|
|
16,16-Dimethylprostaglandin F2α (16,16-Dimethyl-PGF2α) is a potent analog of PGF2α (HY-12956), which exhibits similar binding potency as PGF2α does. 16,16-Dimethylprostaglandin F2α serves as a bronchoconstrictor [1] .
|
-
- HY-173210
-
|
|
Apoptosis
TNF Receptor
|
Cancer
|
|
TNF-α-IN-22 (Compound 30) is a TNFα inhibitor. It can induce Apoptosis by inhibiting the downregulation of IkBα induced by TNFα and blocking the cell cycle. TNF-α-IN-22 can be used in the research of triple-negative breast cancer [1].
|
-
- HY-136828
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
LL-BM123α is a basic antibiotic isolated from Nocardia sp. LL-BM123α exhibits moderate activity against Gram-negative bacteria.
|
-
- HY-U00237B
-
|
|
Adrenergic Receptor
|
Others
|
|
L-771688 hydrochloride is a potent and highly selective α1A-adrenoceptor antagonist (Kd=43-90 pM). L-771688 hydrochloride is effective against cloned human, rat and dog α1A-adrenergic receptors. L-771688 exhibits high affinity (Ki ≤ 1 nM) and over 500-fold selectivity over the α1B and α1D isoforms. L-771688 potently antagonizes norepinephrine-induced responses at these receptors. Inhibits contractions induced by phenylephrine or A-61603 in rat, dog, human and monkey models [1].
|
-
- HY-15746B
-
|
|
Adrenergic Receptor
|
Cardiovascular Disease
Endocrinology
Cancer
|
|
Dobutamine tartrate is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine tartrate is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine tartrate can increase cardiac output and correct hypoperfusion [1] .
|
-
- HY-P0252
-
-
- HY-113962S
-
-
- HY-N0492R
-
|
Thioctic acid (Standard); (±)-α-Lipoic acid (Standard); DL-α-Lipoic acid (Standard)
|
Reference Standards
NF-κB
HIV
Mitochondrial Metabolism
Endogenous Metabolite
Apoptosis
|
Infection
Inflammation/Immunology
Cancer
|
|
α-Lipoic Acid (Standard) is the analytical standard of α-Lipoic Acid. This product is intended for research and analytical applications. α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation [1] . α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .
|
-
- HY-129764A
-
|
17-trans-PGF3α
|
P-glycoprotein
Drug Isomer
|
Inflammation/Immunology
|
|
(17E)-Prostaglandin F3α (17-trans-PGF3α) is a double bond isomer of Prostaglandin F3α (HY-129764) and a potential metabolite of trans dietary fatty acids. (17E)-Prostaglandin F3α has anti-inflammatory activity [1].
|
-
- HY-P1819
-
-
- HY-123311
-
|
|
Adrenergic Receptor
|
Endocrinology
|
|
CP59430 is an azide analog of the α-adrenaline receptor antagonist Prazosin (HY-B0193). P59430 behaves as a competitive antagonist of α1-adrenaline receptor before photolysis. After photolysis, it specifically and irreversibly labels α1-adrenaline receptor and exhibits non-competitive antagonist activity. CP59430 can be used for the study of receptor molecular characterization [1].
|
-
- HY-134471
-
|
|
TNF Receptor
|
Inflammation/Immunology
Cancer
|
|
TNF-α-IN-2 is a potent and orally active inhibitor of tumor necrosis factor alpha (TNFα), with an IC50 of 25 nM in the HTRF assay. TNF-α-IN-2 distorts the TNFα trimer upon binding, leading to aberrant signaling when the trimer binds to TNFR1. TNF-α-IN-2 can be used for the research of rheumatoid arthritis [1].
|
-
- HY-B1204S
-
-
- HY-N7563
-
|
|
EBV
|
Infection
Cancer
|
|
α-Toxicarol is a potent inhibitor of EBV.α-Toxicarol significantly inhibits mouse skin tumor in vivo. α-Toxicarol inhibits the TPA-induced EBV-EA activation [1].
|
-
- HY-B0459
-
-
- HY-N6630
-
-
- HY-103239
-
-
- HY-N0328R
-
|
α-Mangostin (Standard)
|
Fungal
Reactive Oxygen Species (ROS)
Bacterial
Apoptosis
Virus Protease
Reference Standards
|
Cancer
|
|
alpha-Mangostin (Standard) is the analytical standard of alpha-Mangostin. This product is intended for research and analytical applications. alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM.
|
-
- HY-W009122
-
-
- HY-N0710
-
|
α-Cyperone; (+)-α-Cyperone
|
Endogenous Metabolite
|
Inflammation/Immunology
|
|
alpha-Cyperone (α-Cyperone) is associated with the down-regulation of COX-2, IL-6, Nck-2, Cdc42 and Rac1, resulting in reduction of inflammation, which would be highly beneficial for treatment of inflammatory diseases such as AD.
|
-
- HY-W414548
-
|
|
Others
|
Neurological Disease
Metabolic Disease
|
|
7α,27-Dihydroxycholesterol is an oxysterol characterized by its oxidized side chains and is produced through the hydroxylation of 27-Hydroxycholesterol (27-OHC); it serves as a metabolite of interest in lipidomic analyses of various pathological conditions, including neurological diseases, Smith-Lemli-Opitz syndrome, obesity metabolic syndrome, and diabetes. Notably, levels of 7α,27-di-OHC decrease following lipopolysaccharide activation, and it also functions as a ligand for Epstein-Barr virus-induced gene 2 (EBI2). Additionally, 7α,27-di-OHC exists as a structural isomer of 7α,25-dihydroxycholesterol (7α25-OHC).
|
-
- HY-P1545
-
-
- HY-N3002R
-
|
4-Hydroxyphenyl α-D-glucopyranoside (Standard)
|
Reference Standards
Tyrosinase
|
Metabolic Disease
|
|
α-Arbutin (Standard) is the analytical standard of α-Arbutin. This product is intended for research and analytical applications. α-Arbutin (4-Hydroxyphenyl α-D-glucopyranoside) is emerging as popular and effective skin whiteners, acting as tyrosinase inhibitor [1].
|
-
- HY-N0492AR
-
|
Thioctic acid sodium (Standard); (±)-α-Lipoic acid sodium (Standard); DL-α-Lipoic acid sodium (Standard)
|
Reference Standards
NF-κB
HIV
Mitochondrial Metabolism
Endogenous Metabolite
Apoptosis
|
Infection
Inflammation/Immunology
Cancer
|
|
α-Lipoic Acid (sodium) (Standard) is the analytical standard of α-Lipoic Acid (sodium). This product is intended for research and analytical applications. α-Lipoic Acid (Thioctic acid) sodium is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid sodium inhibits NF-κB-dependent HIV-1 LTR activation[1][2][3]. α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells[4]. α-Lipoic Acid sodium can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1[5].
|
-
- HY-136748
-
|
|
HIF/HIF Prolyl-Hydroxylase
|
Cancer
|
|
HIF-2α-IN-4 is a potent inhibitor of hypoxia inducible factor-2α (HIF-2α) translation, with an IC50 of 5 μM. HIF-2α-IN-4 decreases both constitutive and hypoxia-induced HIF-2α protein expression. HIF-2α-IN-4 links its 5'UTR iron-responsive element to oxygen sensing [1].
|
-
- HY-N0683S6
-
-
- HY-117845
-
|
LL-E19085α
|
Bacterial
Antibiotic
|
Infection
|
|
Citreamicin alpha (LL-E 19085-alpha) is an antibiotic whose in vitro antimicrobial activity against 429 clinical isolates of Gram-positive cocci has been tested by the agar dilution method. These microorganisms included 313 strains of Staphylococci and 116 strains of Streptococci. The in vitro activity of Citreamicin alpha was compared with that of ampicillin, amoxicillin, ceftriaxone, erythromycin, and vancomycin. For Staphylococci, the MIC values of Citreamicin alpha ranged from 0.12-4.0 μg/ml, and for Streptococcus pyogenes of the genus Streptococcus, it was 0.03-0.12 μg/ml. However, enterococci were relatively resistant, requiring 2.0 μg/ml of the agent to inhibit 64% of the 62 tested strains. The in vitro activity of this antibiotic was much better than that of ampicillin, amoxicillin, ceftriaxone, and erythromycin, but comparable or slightly inferior to that of vancomycin.
|
-
- HY-W011655
-
|
p-Nitrophenyl Alpha-D-xylopyranoside
|
Biochemical Assay Reagents
|
Others
|
|
p-Nitrophenyl α-D-xylopyranoside (p-Nitrophenyl alpha-D-xylopyranoside) is a chromogenic substrate for α-xylosidase [1].
|
-
- HY-116472
-
|
α-RA-F
|
Endogenous Metabolite
|
Others
|
|
alpha-RA-F (α-RA-F) is a compound that can promote collagen synthesis and has the activity of reducing the expression level of matrix metalloproteinases (MMPs). alpha-RA-F enhances collagen synthesis in human fibroblasts without causing cytotoxicity. alpha-RA-F has demonstrated its important potential in the pharmaceutical, pharmaceutical and cosmetic industries by regulating collagen synthesis and MMPs expression levels [1].
|
-
- HY-P5694
-
|
|
HPV
Parasite
|
Infection
|
|
Human α-defensin 5 is an antiviral peptide. Human α-defensin 5 blocks infection of non-enveloped viruses, including AdV, HPV, and polyomaviruses (IC50: 0.6-1.25 μM for HPV16). Human α-defensin 5 can bind to the viral capsid and blocks escape of the virus from the endosome. Human α-defensin 5 increases HIV binding to the cell surface. Human α-defensin 5 also has parasiticidal activity [1].
|
-
- HY-N1163
-
|
(-)-Tetrahydroalstonine
|
Adrenergic Receptor
Atg8/LC3
Akt
mTOR
|
Neurological Disease
Endocrinology
|
|
Tetrahydroalstonine ((-)-Tetrahydroalstonine) is an indole alkaloid and a selective α₂-adrenergic receptor antagonist. Tetrahydroalstonine exhibits certain neuroprotective effects. Tetrahydroalstonine can regulate autophagy-lysosomal function by activating the Akt/mTOR pathway, significantly reducing OGD/R-induced primary cortical neuronal injury [1] .
|
-
- HY-W743021
-
-
- HY-114573
-
|
|
IKK
Interleukin Related
TNF Receptor
RIP kinase
|
Others
|
|
TNF-α-IN-19 is an inhibitor of TNFα that can block the interaction between TNFαRI, TRADD, and RIP1, the EC50 values for TNFα, IL-1β, and IL-1β/TNFα are 2.451, 3.792 and 1.54 μM, respectively. TNF-α-IN-19 only inhibits the degradation of IκBα when cells are stimulated by TNFα and not by IL-1β [1].
|
-
- HY-130660
-
|
Prostamide F2α
|
Prostaglandin Receptor
|
Endocrinology
|
|
Prostaglandin F2α ethanolamide (Prostamide F2α) is an ethanolamide-like G protein-coupled receptor. Prostaglandin F2α is also a luteinizing hormone in sheep and may be a nociceptive mediator in the spinal cord [1] .
|
-
- HY-P2802B
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
α-Glucosidase, rice is a carbohydrase enzyme that catalyzes the release of α-glucose molecules. α-Glucosidase, rice retains exoglycosidases, which hydrolyze α-glucosidic linkage at the nonreducing end of a substrate [1] .
|
-
- HY-137873
-
|
4-Methylumbelliferyl-α-D-Glucose; 4-Methylumbelliferyl-α-D-Glucoside; 4-MU-α-D-Glucopyranoside
|
Fluorescent Dye
Glycosidase
|
Others
|
|
4-Methylumbelliferyl-α-D-Glucopyranoside (4-Methylumbelliferyl-α-D-Glucose) is a fluorescent substrate for α-glucosidase, which releases the fluorescent moiety 4-methylumbelliferyl (4-MU) upon cleavage. 4-MU has pH-dependent fluorescence excitation activity, with excitation wavelengths of 320 nm at low pH (1.97-6.72) and 360 nm at high pH (7.12-10.3), respectively. The emission wavelength of 4-Methylumbelliferyl-α-D-Glucopyranoside increases with decreasing pH, ranging from 445-455 nm. 4-Methylumbelliferyl-α-D-Glucopyranoside can be used as a biomarker for Fabry and Pompe diseases to quantify α-glucosidase activity in infant blood spot samples.
|
-
- HY-118638
-
-
- HY-107326
-
-
- HY-107326A
-
-
- HY-114522
-
|
|
Biochemical Assay Reagents
|
Others
|
|
X-alpha-Gal is a chromogenic substrate that is used to screen colonies with high activity of β-galactopyranoside. X-alpha-Gal also detects α-galactosidase activity. X-alpha-Gal can be used in yeast two hybrid screening for MEL1 gene activation. X- alpha -Gal can be used with Matchmaker GAL4-based products to confirm protein interactions[1][2][3].
|
-
- HY-15746S1
-
|
|
Isotope-Labeled Compounds
Adrenergic Receptor
|
Cardiovascular Disease
Endocrinology
|
|
(rac)-Dobutamine-d6 (hydrochloride) is a labelled racemic Dobutamine hydrochloride. Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion [1] .
|
-
- HY-15746S
-
|
|
Isotope-Labeled Compounds
Adrenergic Receptor
|
Cardiovascular Disease
Endocrinology
|
|
(rac)-Dobutamine-d4 (hydrochloride) is a labelled racemic Dobutamine hydrochloride. Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion [1] .
|
-
- HY-158805
-
-
- HY-P1482
-
|
Mating Factor α
|
Sex Pheromone
|
Endocrinology
|
|
α-Factor Mating Pheromone, yeast is a tridecapeptide secreted by S. cerevisiae α cells via Ste2p receptor.
|
-
- HY-W776875
-
-
- HY-W709830
-
|
|
Drug Derivative
|
Neurological Disease
|
|
α-Propylaminopentiophenone hydrochloride is a substituted cathinone that has propyl groups both at the α position of the cathinone structure and at the amine.
|
-
- HY-W706595
-
|
|
Drug Derivative
|
Neurological Disease
|
|
N,α-Diethylphenethylamine hydrochloride is an N-substituted amphetamine with an ethyl group attached to the amine. N,α-Diethylphenethylamine hydrochloride is an anorectic.
|
-
- HY-N6968R
-
|
Humulene (Standard); α-Caryophyllene (Standard)
|
Reference Standards
NO Synthase
COX
|
Inflammation/Immunology
|
|
α-Humulene (Standard) is the analytical standard of α-Humulene. This product is intended for research and analytical applications. α-Humulene is a main constituent of Tanacetum vulgare L. (Asteraceae) essential oil with anti-inflammation (IC50=15±2 μg/mL). α-Humulene inhibits COX-2 and iNOS expression [1].
|
-
- HY-118260
-
|
|
Adrenergic Receptor
|
Endocrinology
|
|
Phendioxan is a compound with binding activity at the α(1)-adrenaline receptor subtype. The facilitated membrane diffusion of phendioxan is thought to be associated with improved α(1d)-AR affinity. Docking simulations of phendioxan at biological targets supported the stoichiometric analysis and revealed the importance of polar, electrostatic, hydrophobic, and shape effects of its phenoxy terminal orthogonal substituents on ligand binding [1].
|
-
- HY-N9848
-
|
|
Others
|
Cancer
|
|
2α,3α,24-Trihydroxyursa-12,20(30)-dien-28-oic acid is a triterpenoid with anticancer effects. 2α,3α,24-Trihydroxyursa-12,20(30)-dien-28-oic acid inhibits HepG2, A549, MCF-7, SK-OV-3, and HeLa cells with IC50 values of 19.62 μM, 18.86 μM, 45.94 μM, 62.41 μM, and 28.74 μM, respectively [1].
|
-
- HY-W014118R
-
|
|
Reference Standards
Others
|
Cancer
|
|
α-Hexylcinnamaldehyde (Standard) is the analytical standard of α-Hexylcinnamaldehyde. This product is intended for research and analytical applications. α-Hexylcinnamaldehyde, a compound derived from Cinnamaldehyde. α-Hexylcinnamaldehyde has the potential antimutagenic and chemosensitizing properties. α-Hexylcinnamaldehyde is widely used as an ingredient in many personal care, and as an additive in food and the pharmaceutical industry [1].
|
-
- HY-145463
-
|
|
5-HT Receptor
|
Cardiovascular Disease
|
|
α-Methylserotonin is a potent and selective agonist of 5-HT2 receptor. α-Methylserotonin is an analogue of serotonin formed in vivo from α-methyltryptophan. α-Methylserotonin mediates the lymphatic smooth muscle contraction and prevents the up-regulation of serotonin-receptor-mediated phosphoinositide hydrolysis [1] .
|
-
- HY-100993
-
|
|
5-HT Receptor
|
Cardiovascular Disease
|
|
α-Methylserotonin maleate is a potent and selective agonist of 5-HT2 receptor. α-Methylserotonin maleate is an analogue of serotonin formed in vivo from α-Methyltryptophan. α-Methylserotonin maleate mediates the lymphatic smooth muscle contraction and prevents the up-regulation of serotonin-receptor-mediated phosphoinositide hydrolysis [1] .
|
-
- HY-119593
-
-
- HY-172032
-
-
- HY-18370
-
|
|
HIF/HIF Prolyl-Hydroxylase
|
Cancer
|
|
HIF-2α-IN-3, an allosteric inhibitor of hypoxia inducible factor-2α (HIF-2α), exhibits an IC50 of 0.4 µM and a KD of 1.1 µM. Anticancer agent [1].
|
-
- HY-153584
-
|
|
GABA Receptor
|
Neurological Disease
|
|
MRK-898 is an orally active GABA(A) receptor modulator. MRK-898 binds to α1, α2, α3 or α5 subunit of GABA(A) receptor with Ki values of 1.2 nM, 1.0 nM, 0.73 nM, and 0.50 nM, respectively. However, α1-containing GABA(A) receptors are identified as the "sedative" and α2- and/or α3-containing receptors as the "anxiolytic" subtype(s) [1].
|
-
- HY-153329
-
|
|
TNF Receptor
|
Others
|
|
TNF-α-IN-9 (compound 48) is a analog of NDM-1 inhibitor-3 (HY-150758). TNF-α-IN-9 is a TNF-α inhibitor. TNF-α-IN-9 shows low inhibitory activity [1].
|
-
- HY-W014118
-
|
|
Drug Derivative
|
Cancer
|
|
α-Hexylcinnamaldehyde, a compound derived from Cinnamaldehyde. α-Hexylcinnamaldehyde has the potential antimutagenic and chemosensitizing properties. α-Hexylcinnamaldehyde is widely used as an ingredient in many personal care, and as an additive in food and the pharmaceutical industry [1].
|
-
- HY-131696
-
|
11-deoxy PGF1α
|
Prostaglandin Receptor
|
Cardiovascular Disease
Others
|
|
11-deoxy Prostaglandin F1α (11-deoxy PGF1α) is an analog of prostaglandin F1α, exhibits side effects on intestines and causes the uterine contraction. 11-deoxy Prostaglandin F1α exhibits activity as vasopressor and bronchoconstrictor [1] .
|
-
- HY-N1719
-
|
2α,3α,23-Trihydroxyolean-12-en-28-oic acid
|
Others
|
Others
|
|
Isoarjunolic acid (2α,3α,23-Trihydroxyolean-12-en-28-oic acid) is a triterpenoid, can be isolated from the stems of Cornus kousa. Isoarjunolic acid could have free radical scavenging activity and elastase inhibition activity [1].
|
-
- HY-153330
-
-
- HY-114771
-
-
- HY-W719025
-
|
|
Drug Derivative
|
Neurological Disease
|
|
α-Ethylaminopentiophenone hydrochloride is a substituted Cathinone that is an analog to ethcathinone, differing by having propyl rather than methyl at the α position.
|
-
- HY-165023
-
|
4-Bromo-α-PVP hydrochloride; 4-Bromo-α-Pyrrolidinopentiophenone hydrochloride
|
Biochemical Assay Reagents
|
Others
|
|
4-Bromo-α-pyrrolidinovalerophenone (hydrochloride) is a biochemical reagent.
|
-
- HY-N2794
-
|
α-Dihydrocaryopterone
|
NO Synthase
|
Inflammation/Immunology
|
|
9-Hydroxy-α-lapachone (α-Dihydrocaryopterone) is a natural phenol, exhibits potent inhibitory effects with an IC50 of 4.64 µM on LPS-induced NO production in RAW 264.7 cells [1].
|
-
- HY-N12876
-
|
(18α)-Oleanic acid; (18α)-Caryophyllin
|
Others
|
Cancer
|
|
18α-Oleanolic acid is a natural pentacyclic triterpenic acid that can be isolated from plants [1].
|
-
- HY-166970
-
|
|
Biochemical Assay Reagents
|
Others
|
|
3α,4β,3α-Galactotetraose is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology [1].
|
-
- HY-P5846
-
|
MT3
|
mAChR
Adrenergic Receptor
|
Neurological Disease
|
|
Muscarinic toxin 3 (MT3) is a potent and non-competitive mAChR and adrenoceptors antagonist with pIC50s of 6.71, 8.79, 8.86, 7.57, 8.13, 8.49, <6.5, 7.29 against M1, M4, α1A, α1B, α1D,α2A,α2B and α2C receptors, respectively. Muscarinic toxin 3 displays prominent adrenoceptor activity [1].
|
-
- HY-N13420
-
|
|
Others
|
Others
|
|
3beta-Acetoxy-11alpha,12alpha-epoxyoleanan-28,13beta-olide is a natural product [1].
|
-
- HY-134163
-
|
4-Methylumbelliferyl Alpha-L-arabinopyranoside
|
Biochemical Assay Reagents
|
Others
|
|
4-Methylumbelliferyl α-L-arabinopyranoside (4-Methylumbelliferyl alpha-L-arabinopyranoside) is a substrate for enzymes that hydrolyze arabinose-containing substrates, such as α-L-arabinopyranoside [1].
|
-
- HY-138871
-
-
- HY-101815
-
-
- HY-P2602
-
|
|
GABA Receptor
|
Neurological Disease
|
|
α-Casozepine is a bioactive peptide derived from the α protein S1 casein in milk and has an affinity for γ-aminobutyric acid (GABA) receptors in the brain. α-Casozepine has anti-anxiety effects [1] .
|
-
- HY-144178
-
-
- HY-137544
-
|
16-Phenyl tetranor PGF2α
|
Prostaglandin Receptor
Drug Metabolite
|
Metabolic Disease
|
|
16-phenyl tetranor Prostaglandin F2α (16-phenyl tetranor PGF2α) is a metabolically stable analog of PGF2α. The affinity of 16-phenyl tetranor PGF2α at the FP receptor of ovine luteal cells is poor (8.7%) compared to PGF2α.
|
-
- HY-CE00056
-
|
(24R,25R)-3Alpha,7Alpha,24-trihydroxy-5beta-cholestan-26-oyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
|
(24R,25R)-3Alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA ((24R,25R)-3Alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-coenzyme A) is a steroidal acyl-CoA.
|
-
- HY-171254
-
|
|
p38 MAPK
|
Inflammation/Immunology
|
|
p38-α MAPK-IN-9 (Compound 25a) is a p38-α MAPK inhibitor (Ki: 0.057 nM). p38-α MAPK-IN-9 inhibits LPS (HY-D1056) induced TNFα production in hPBMCs (IC50: 18 nM) [1].
|
-
- HY-137178
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
20α,22R-Dihydroxycholesterol is an endogenous metabolic intermediate. 20α,22R-Dihydroxycholesterol involved in the biosynthesis of cholesterol to steroid hormones [1].
|
-
- HY-W040294
-
|
Methyl α-D-glucopyranoside
|
Biochemical Assay Reagents
|
Others
|
|
Methyl α-D-glucoside (Methyl α-D-glucopyranoside) can be used for protein glycosylation modification. Methyl α-D-glucoside is a kind of biological materials or organic compounds that are widely used in life science research [1].
|
-
- HY-N3037R
-
|
α-Boswellic acid acetate (Standard)
|
Reference Standards
Others
|
Inflammation/Immunology
|
|
3-O-Acetyl-α-boswellic acid (Standard) is the analytical standard of 3-O-Acetyl-α-boswellic acid. This product is intended for research and analytical applications. 3-O-Acetyl-α-boswellic acid suppresses T cell function [1].
|
-
- HY-121618
-
|
|
GABA Receptor
Reactive Oxygen Species (ROS)
Parasite
Apoptosis
Autophagy
|
Infection
Neurological Disease
|
|
α-Thujone is a monoterpene isolated from Thuja occidentalis essential oil with potent anti-tumor activities. α-Thujone is a reversible modulator of the GABA type A receptor and the IC50 for α-Thujone is 21 μM in suppressing the GABA-induced currents. α-Thujone induces ROS accumulation-dependent cytotoxicity, also induces cell apoptosis and autophagy. α-Thujone has antinociceptive, insecticidal, and anthelmintic activity, and can cross the blood-brain barrier [1] .
|
-
- HY-N5142
-
|
|
Bacterial
Antibiotic
NF-κB
AMPK
Fungal
|
Infection
Neurological Disease
Metabolic Disease
Inflammation/Immunology
|
|
α-Terpineol (with oral activity) can be found in Eucalyptus globulus Labill. α-Terpineol exhibits strong antimicrobial activity against periodontopathic and cariogenic bacteria.α-Terpineol possesses antifungal activity against T. mentagrophytes, and the activity might lead to irreversible cellular disruption. In addition, α-Terpineol exhibits antineuropathic and anti-inflammatory activities.
α-Terpineol can be utilized in research related to diarrhea, neuropathic pain, infections, and inflammation [1] .
|
-
- HY-165164
-
|
|
Others
|
Cancer
|
|
Methotrexate-alpha-alanine is a prodrug for activation by enzyme-monoclonal antibody conjugates. Methotrexate-alpha-alanine shows cytotoxicity [1] .
|
-
- HY-123489S
-
|
THDOC-d3
|
GABA Receptor
|
Neurological Disease
|
|
3α,21-Dihydroxy-5α-pregnan-20-one-d3 is the deuterium labeled 3α,21-Dihydroxy-5α-pregnan-20-one. 3α,21-Dihydroxy-5α-pregnan-20-one (THDOC), an endogenous neurosteroid, is a positive modulator of GABAA receptors. 3α,21-Dihydroxy-5α-pregnan-20-one potentiates neuronal response to low concentrations of GABA at α4β1δ GABAA receptors in vitro.
|
-
- HY-15746R
-
|
|
Reference Standards
Adrenergic Receptor
|
Cardiovascular Disease
Endocrinology
Cancer
|
|
Dobutamine (hydrochloride) (Standard) is the analytical standard of Dobutamine (hydrochloride). This product is intended for research and analytical applications. Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion [1] .
|
-
- HY-N4155
-
|
|
EBV
HIV Protease
HSV
|
Infection
Cancer
|
|
2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid, a natural ursane-type triterpene, is a potent inhibitor of HIV protease (HIV Protease). 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid is also an inhibitor of the activation of Epstein-Barr virus early antigen (EBV-EA). 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid displays an inhibitory activity against nitric oxide production in Lipopolysaccharide (Lipopolysaccharides)-activated RAW 264.7 cells [1] .
|
-
- HY-122221
-
-
- HY-NP009
-
|
|
Biochemical Assay Reagents
|
Others
|
|
α-Lactalbumin is a Ca 2+-binding protein. α-Lactalbumin has a single strong Ca 2+-binding site and for this reason it frequently serves as a simple model Ca 2+-binding protein. α-Lactalbumin is a component of lactose synthase, an enzyme system, which consists of galactosyltransferase (GT) and α-Lactalbumin [1] .
|
-
- HY-142618
-
-
- HY-114729
-
|
|
Amino Acid Derivatives
|
Others
|
|
Leucylproline, a dipeptide, plays important roles in the medium-dependent regulation of proteinase activity [1].
|
-
- HY-121618R
-
|
|
GABA Receptor
Reactive Oxygen Species (ROS)
Parasite
Apoptosis
Autophagy
|
Infection
Neurological Disease
|
|
α-Thujone (Standard) is the analytical standard of α-Thujone. This product is intended for research and analytical applications. α-Thujone is a monoterpene isolated from Thuja occidentalis essential oil with potent anti-tumor activities. α-Thujone is a reversible modulator of the GABA type A receptor and the IC50 for α-Thujone is 21 μM in suppressing the GABA-induced currents. α-Thujone induces ROS accumulation-dependent cytotoxicity, also induces cell apoptosis and autophagy. α-Thujone has antinociceptive, insecticidal, and anthelmintic activity, and easily penetrates the blood-brain barrier [1] .
|
-
- HY-123422
-
|
|
HIF/HIF Prolyl-Hydroxylase
|
Cardiovascular Disease
|
|
GSK360A is a potent and orally active HIF-PHD inhibitor with IC50 values of 10, 100, and 126 nM for PHD1, PHD2, and PHD3, respectively. GSK360A activates the HIF-1 alpha pathway and protect the failing heart after myocardial infarction (MI) [1].
|
-
- HY-W049706
-
-
- HY-N11477
-
|
|
Glycosidase
|
Metabolic Disease
|
|
(2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid is a saponin that can be isolated from Rubus ellipticus var. obcordatus. (2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid inhibits α-Glucosidase with an IC50 of 1.68 mM [1].
|
-
- HY-N6968
-
|
Humulene; α-Caryophyllene
|
NO Synthase
COX
|
Inflammation/Immunology
|
|
α-Humulene is a main constituent of Tanacetum vulgare L. (Asteraceae) essential oil with anti-inflammation (IC50=15±2 μg/mL). α-Humulene inhibits COX-2 and iNOS expression [1].
|
-
- HY-N2790
-
|
9,13α-Epidioxy-8(14)-abieten-18-oic acid
|
Others
|
Others
|
|
9α,13α-Epidioxyabiet-8(14)-en-18-oic acid (9,13α-Epidioxy-8(14)-abieten-18-oic acid) is a Sesquiterpenoids product that can be isolated from the rhizomes of Carpesium abrotanoides [1].
|
-
- HY-U00165
-
-
- HY-N0347R
-
|
|
Progesterone Receptor
Reference Standards
|
Endocrinology
|
|
17α-Hydroxyprogesterone acetate (Standard) is the analytical standard of 17α-Hydroxyprogesterone acetate. This product is intended for research and analytical applications. 17α-Hydroxyprogesterone acetate possesses progestational activity. 17α-Hydroxyprogesterone acetate has antiinflammatory effects at the murine maternal-fetal interface [1] .
|
-
- HY-101274A
-
-
- HY-122485
-
|
|
Others
|
Others
|
|
α-Copaene, a sesquiterpene hydrocarbon, is a fruit volatile. α-Copaene can be used as an oviposition promoter of Bactrocera oleae [1].
|
-
- HY-N6911A
-
|
|
Others
|
Inflammation/Immunology
|
|
18α-Glycyrrhizic acid is a derivate of Glycyrrhizic acid. 18α-Glycyrrhizic acid has weak antihepatotoxic anti-inflammatory activities [1].
|
-
- HY-N14905
-
|
|
Antibiotic
Bacterial
Fungal
|
Infection
|
|
α-Prumycin hydrochloride is a carbohydrate antibiotic. α-Prumycin hydrochloride has anti-fungal activity and weak anti-individual bacterial activity.
|
-
- HY-146788S
-
-
- HY-B1278S1
-
-
- HY-W049706R
-
|
Penta-O-acetyl-α-D-glucopyranose (Standard)
|
Biochemical Assay Reagents
Reference Standards
|
Others
|
|
α-D-Glucose pentaacetate (Standard) is the analytical standard of α-D-Glucose pentaacetate. This product is intended for research and analytical applications. α-D-Glucose pentaacetate (Penta-O-acetyl-α-D-glucopyranose) is a synthetic sugar compound.
|
-
- HY-115433R
-
-
- HY-144176
-
-
- HY-113031S
-
-
- HY-400897
-
|
|
Ligands for Target Protein for PROTAC
EBI2/GPR183
|
Cancer
|
|
7α,25-Dihydroxycholesterol intermediate-1 is an intermediate in the synthesis of 7α,25-Dihydroxycholesterol (HY-113962). 7α,25-Dihydroxycholesterol (7α,25-OHC) can be used as a ligand to target the orphan GPCR receptor EBI2 (GPR183). body, used to synthesize the corresponding PROTEACs [1].
|
-
- HY-15672
-
|
|
HIF/HIF Prolyl-Hydroxylase
|
Neurological Disease
Cancer
|
|
FM19G11 is a hypoxia-inducible factor-1-alpha (HIF-1α) inhibitor, and it inhibits hypoxia-induced luciferase activity with an IC50 of 80 nM in HeLa cells. FM19G11 modulates other signaling pathways, including mTOR and PI3K/Akt/eNOS, when the HIF-1α pathway is inactivated under normoxic conditions [1] .
|
-
- HY-N3002
-
|
4-Hydroxyphenyl α-D-glucopyranoside
|
Tyrosinase
|
Neurological Disease
Metabolic Disease
Cancer
|
|
α-Arbutin (4-Hydroxyphenyl α-D-glucopyranoside) is a tyrosinase inhibitor, which is used as an effective skin whiteners. α-Arbutin is promising for research of various diseases such as hyperpigmentation disorders, types of cancers, central nervous system disorders, osteoporosis, diabetes [1] .
|
-
- HY-113344R
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
16α-Hydroxyestrone (Standard) is the analytical standard of 16α-Hydroxyestrone. This product is intended for research and analytical applications. 16α-Hydroxyestrone (16αOHE) is a major Estradiol metabolite. 16α-Hydroxyestrone (16αOHE) can be used for the research of metabolic disease [1].
|
-
- HY-W106550
-
|
Pentaacetyl-α-D-galactopyranose
|
Biochemical Assay Reagents
|
Others
|
|
α-D-Galactose pentaacetate (Pentaacetyl-α-D-galactopyranose) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-165292
-
|
α-Eudesmol
|
Calcium Channel
|
Others
|
|
(-)-α-Eudesmol is a diterpene dialdehyde that can be isolated from Porella [1].
|
-
- HY-160437
-
|
|
TNF Receptor
|
Inflammation/Immunology
|
|
TNF-α-IN-16 is a potent TNFα inhibitor with an IC50 of <0.6 μM. TNF-α-IN-16 has antiinflammatory properties (WO2001072735A2; example 18) [1].
|
-
- HY-112275
-
-
- HY-160434
-
|
|
TNF Receptor
|
Inflammation/Immunology
|
|
TNF-α-IN-13 is a potent TNFα inhibitor with an IC50 of <0.6 μM. TNF-α-IN-13 has antiinflammatory properties (WO2001072735A2; example 6) [1].
|
-
- HY-163598
-
-
- HY-N12119
-
|
|
Endogenous Metabolite
|
Others
|
|
ent-Prostaglandin F2α is the opposite enantiomer of PGF2α. ent-Prostaglandin F2α can be found in urine [1].
|
-
- HY-P10189
-
-
- HY-15484R
-
|
|
MDM-2/p53
Aryl Hydrocarbon Receptor
Ferroptosis
Apoptosis
|
Cancer
|
|
Pifithrin-α (hydrobromide) (Standard) is the analytical standard of Pifithrin-α (hydrobromide). This product is intended for research and analytical applications. Pifithrin-α hydrobromide is a p53 inhibitor which blocks its transcriptional activity and prevents cells from apoptosis. Pifithrin-α hydrobromide is also an aryl hydrocarbon receptor (AhR) agonist.
|
-
- HY-N6710R
-
|
|
Reference Standards
Estrogen Receptor/ERR
|
Inflammation/Immunology
|
|
α-Zearalenol (Standard) is the analytical standard of α-Zearalenol. This product is intended for research and analytical applications. α-Zearalenol is a Mycotoxin with high affinity for the estrogen receptors (ER), α-Zearalenol is the derivative of zearalenone (ZEN), causes reproductive disorders in animals, due to its xenoestrogenic effects [1].
|
-
- HY-W744680
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Neurological Disease
|
|
5α-Dihydrodeoxycorticosterone-d7 is the deuterium labeled 5α-Dihydrodeoxycorticosterone (HY-W743870). 5α-Dihydrodeoxycorticosterone is an intermediate product of Deoxycorticosterone (HY-113414) catalyzed by 5α-reductase. 5α-Dihydrodeoxycorticosteron levels associated with depression [1].
|
-
- HY-106720
-
|
YM 09538
|
Adrenergic Receptor
|
Cardiovascular Disease
|
|
Amosulalol (YM 09538) is an orally active and dual inhibitor of α1/β1-Adrenergic Receptor. Amosulalol exhibits antihypertensive activity via α1-Adrenergic Receptor inhibition. Amosulalol decreases reflexogenic increases in heart rate and plasma renin activity (PRA) via β1-Adrenergic Receptor inhibition in spontaneously hypertensive rats (SHR) [1].
|
-
- HY-106720A
-
|
YM 09538 hydrochloride
|
Adrenergic Receptor
|
Cardiovascular Disease
|
|
Amosulalol (YM 09538) hydrochloride is an orally active and dual inhibitor of α1/β1-Adrenergic Receptor. Amosulalol hydrochloride exhibits antihypertensive activity via α1-Adrenergic Receptor inhibition. Amosulalol hydrochloride decreases reflexogenic increases in heart rate and plasma renin activity (PRA) via β1-Adrenergic Receptor inhibition in spontaneously hypertensive rats (SHR) [1].
|
-
- HY-N10673
-
|
|
Others
|
Cancer
|
|
10α-Hydroxyepigambogic acid can be extracted from Garcinia hanburyi. 10α-Hydroxyepigambogic acid can be used in the research of tumors [1].
|
-
- HY-B0354AR
-
|
|
Reference Standards
5-HT Receptor
Adrenergic Receptor
|
Cardiovascular Disease
Endocrinology
|
|
Urapidil (hydrochloride) (Standard) is the analytical standard of Urapidil (hydrochloride). This product is intended for research and analytical applications. Urapidil hydrochloride is an orally active α1-adrenoceptor antagonist and 5-HT1A receptor agonist with a pIC50 of 6.13 and 4.38 against α1- and α2-adrenoceptor, respectively. Urapidil hydrochloride shows antihypertensive effect [1] .
|
-
- HY-16686R
-
|
Alpha-Tocopherol phosphate (Standard); TocP (Standard); vitamin E phosphate (Standard)
|
Reactive Oxygen Species (ROS)
Endogenous Metabolite
Reference Standards
|
Cancer
|
|
α-Tocopherol (phosphate) (Standard) is the analytical standard of α-Tocopherol (phosphate). This product is intended for research and analytical applications. α-Tocopherol phosphate is a compound with the high activity of vitamin E.
|
-
- HY-N12995
-
-
- HY-N7264
-
-
- HY-149668
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-41 (compound 5o) is a potent α-glucosidase inhibitor. α-Glucosidase-IN-41 can arise the changed secondary structure of α-Glu to hinder enzyme catalytic activity. α-Glucosidase-IN-41 can be used for diabetes mellitus research [1].
|
-
- HY-161764
-
|
|
Amylases
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-67 (compound 5k) is a potent α-Glucosidase inhibitor with IC50 values of 0.31, 4.51 µM for alpha-glucosidase and alpha-amylase, respectively. α-Glucosidase-IN-67 has the potential for the research of type-2 diabetes [1].
|
-
- HY-105058A
-
|
14α/β-RU 24722
|
Others
|
Neurological Disease
|
|
14α/β-Vindeburnol (14α/β-RU 24722) a synthetic molecule derived from the eburnamine-vincamine alkaloid group, has many neuropsychopharmacological and antidepressant-like effects [1].
|
-
- HY-P1875
-
-
- HY-P0252A
-
-
- HY-145751
-
|
7α-Hydroxydehydroepiandrosterone; 3β,7α-Dihydroxy-Δ5-androsten-17-one
|
Cytochrome P450
Mitochondrial Metabolism
|
Metabolic Disease
Cancer
|
|
7α-Hydroxy-DHEA (7α-Hydroxydehydroepiandrosterone) is a 7α-hydroxylated metabolite of DHEA (HY-14650), catalyzed by intracellular steroid 7α-hydroxylases such as P450 2A1. 7α-Hydroxy-DHEA exhibits biological activity comparable to DHEA but does not convert into compounds with androgenic or estrogenic activity. It induces the activity of thermogenic enzymes such as mitochondrial sn-glycerol-3-phosphate dehydrogenase and cytosolic malic enzyme, enhancing heat production and reducing food utilization efficiency. As a more efficient and safer metabolite compared to DHEA, 7α-Hydroxy-DHEA holds potential for studies in the fields of obesity, metabolic diseases, and adrenal carcinoma [1].
|
-
- HY-163599
-
-
- HY-163601
-
-
- HY-163602
-
-
- HY-163600
-
-
- HY-163597
-
-
- HY-163603
-
-
- HY-148925
-
|
|
Glycosidase
|
Inflammation/Immunology
|
|
α-Amyrenone is a triterpenoid that occurs naturally in very low concentrations in several oleoresins from Brazilian Amazon species of Protium (Burseraceae). The mixture of α and β-amyrenone inhibits α-glucosidase, and can reduce mechanical hypersensitivity and paw-oedema induced by carrageenan [1].
|
-
- HY-139063
-
-
- HY-B1278B
-
|
(±)-Vitamin E acetate
|
Biochemical Assay Reagents
|
Infection
|
|
(±)-α-Tocopherol acetate ((±)-Vitamin E acetate), is a orally active synthetic form of vitamin E. (±)-α-Tocopherol acetate is the ester of acetic acid and α-tocopherol. (±)-α-Tocopherol acetate can be used for the research of the susceptibility of farmed fish to infectious diseases [1].
|
-
- HY-B0225B
-
|
L-(-)-α-Methyldopa hydrate; MK-351 hydrate
|
Adrenergic Receptor
Endogenous Metabolite
|
Cardiovascular Disease
Endocrinology
|
|
Methyldopa hydrate (L-(-)-α-Methyldopa hydrate), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrate is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system [1] .
|
-
- HY-B0225A
-
|
L-(-)-α-Methyldopa hydrochloride; MK-351 hydrochloride
|
Adrenergic Receptor
Endogenous Metabolite
|
Cardiovascular Disease
Endocrinology
|
|
Methyldopa hydrochloride (L-(-)-α-Methyldopa hydrochloride) hydrochloride, a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrochloride is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system [1] .
|
-
- HY-B0225
-
-
- HY-N2854
-
-
- HY-W013407
-
|
|
Tyrosine Hydroxylase
Thyroid Hormone Receptor
|
Neurological Disease
|
|
α-Methyltyrosine methyl ester hydrochloride is an orally active and competitive tyrosine hydroxylase inhibitor. α-Methyltyrosine methyl ester hydrochloride can inhibit the conversion of tyrosine to dopamine. α-Methyltyrosine methyl ester hydrochloride causes kidney damage and urethral calculi in rats. α-Methyltyrosine methyl ester hydrochloride can be used as a tool for sympathetic nervous system research [1].
|
-
- HY-130594
-
|
6α-PGI1
|
Prostaglandin Receptor
|
Others
|
|
6α-Prostaglandin I1 (6α-PGI1) is an analogue of prostacycline I2 (PGI2) and is resistant to hydrolysis in aqueous solution [1].
|
-
- HY-160435
-
|
|
TNF Receptor
|
Inflammation/Immunology
|
|
TNF-α-IN-14 is a potent and selective TNFα inhibitor with an IC50 value of 1.1 µM. TNF-α-IN-14 shows antiinflammatory properties (WO2001072735A2; compound 12) [1].
|
-
- HY-N8423R
-
|
|
Reference Standards
ERK
GSK-3
|
Neurological Disease
Metabolic Disease
|
|
α-Amyrin (Standard) is the analytical standard of α-Amyrin. This product is intended for research and analytical applications. α-Amyrin is a pentacyclic triterpenoid compound with oral activity. α-Amyrin activates the ERK and GSK-3β signaling pathways. α-Amyrin can be used in the study of metabolic syndrome induced by high fructose diet and cognitive dysfunction caused by low cholinergic neurotransmission [1] .
|
-
- HY-Y0585
-
|
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
D-(-)-Mandelic acid is an orally active alpha hydroxycarboxylic acid that can be isolated from bitter almonds and Indian chestnut trees. It has antioxidant and antibacterial properties and is expected to play an important role in the treatment of rheumatoid arthritis [1][4].
|
-
- HY-150560
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-11 is a highly permeable competitive α-glucosidase inhibitor with the IC50 value of 0.56 μM. α-Glucosidase-IN-11 binds to Trp residues in α-glucosidase and regulates protein folding. α-Glucosidase-IN-11 can be used to regulate blood glucose levels [1].
|
-
- HY-113031S1
-
-
- HY-N0328
-
-
- HY-P2802A
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
α-Glucosidase, bacillus stearothermophilus is a carbohydrase enzyme that catalyzes the release of α-glucose molecules. α-Glucosidase, bacillus stearothermophilus retains exoglycosidases, which hydrolyze α-glucosidic linkage at the nonreducing end of a substrate [1] .
|
-
- HY-B0459A
-
|
6,7-Epoxytropine hydrochloride
|
Adrenergic Receptor
|
Neurological Disease
Endocrinology
|
|
Scopine hydrochloride (6,7-Epoxytropine hydrochloride) is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock.
|
-
- HY-P1442
-
|
|
Adrenergic Receptor
|
Cancer
|
|
AdTx1 is a selective α1A-adrenoceptor antagonist (Ki: 0.35 nM). AdTx1 can be used for research of benign prostatic hyperplasia [1].
|
-
- HY-167925
-
-
- HY-131449
-
|
|
Adrenergic Receptor
|
Others
|
|
Terazosin dimer impurity dihydrochloride, a dimer of Terazosin, is an impurity of Terazosin. Terazosin is a quinazoline derivative and a competitive and orally active α1-adrenoceptor antagonist [1].
|
-
- HY-113960
-
|
|
Estrogen Receptor/ERR
|
Cancer
|
|
ERRα antagonist-1 (Compound A) is a selective and high affinity agonist for estrogen-related receptor α (ERRα). ERRα antagonist-1 inhibits interaction of ERRα with Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β, the IC50 values are 170 nM and 180 nM, respectively [1].
|
-
- HY-N7148S
-
-
- HY-146981
-
-
- HY-P10223
-
|
|
HIF/HIF Prolyl-Hydroxylase
|
Cancer
|
|
Cyclo CRVIIF is a dual inhibitor for hypoxia inducible factor (HIF) 1 and 2, which disrupts the interaction of both HIF1-α and HIF2-α with HIF1-β, with affinity for HIF1-α and HIF2-α PAS-B domains KD of 65 and 123 μM, respectively [1].
|
-
- HY-N1527
-
|
Quinovic acid 3-O-α-L-rhamnoside
|
Others
|
Others
|
|
Quinovic acid 3-O-α-L-rhamnopyranoside (Quinovic acid 3-O-α-L-rhamnoside) is glycoside derivative. Quinovic acid 3-O-α-L-rhamnopyranoside can be isolated from the root bark of Guettarda angelica [1].
|
-
- HY-N9175
-
|
|
Others
|
Others
|
|
4α,6α-Dihydroxyeudesm-11(13)-en-12,8β-olide is a Sesquiterpenoids product that can be isolated from the herbs of Chloranthus elatior [1].
|
-
- HY-12753A
-
|
SR35021 hydrochloride
|
Thyroid Hormone Receptor
|
Cardiovascular Disease
|
|
Debutyldronedarone (SR35021) hydrochloride, the main metabolite of Dronedarone, is a selective thyroid hormone receptor α1 (TRα1) inhibitor. Debutyldronedarone hydrochloride inhibits T3 binding to TRα1 and TRβ1 by 77% and 25%, respectively. Debutyldronedarone hydrochloride can be used for the research of arrhythmic [1].
|
-
- HY-N7830
-
|
|
ERK
|
Cancer
|
|
7α,15-Dihydroxydehydroabietic acid is a natural abietane-type diterpenoid with antiangiogenic effects [1].
|
-
- HY-43470R
-
|
|
Reference Standards
Endogenous Metabolite
|
Metabolic Disease
|
|
3α,12β-Dihydroxycholanoic acid (Standard) is the analytical standard of 3α,12β-Dihydroxycholanoic acid. This product is intended for research and analytical applications. 3α,12β-Dihydroxycholanoic acid is a bile acid that can be isolated from urine specimens of healthy humans[1].
|
-
- HY-N0347
-
|
|
Progesterone Receptor
|
Endocrinology
|
|
17α-Hydroxyprogesterone acetate possesses progestational activity. 17α-Hydroxyprogesterone acetate has antiinflammatory effects at the murine maternal-fetal interface [1] .
|
-
- HY-N11697
-
|
|
P-glycoprotein
|
Cancer
|
|
α-Cryptoxanthin is a natural carotenoid with anticancer effects. α-Cryptoxanthin inhibits multidrug resistance 1 (MDR1) mediated efflux pump [1].
|
-
- HY-W020044S1
-
|
|
Ferroptosis
|
Others
|
|
DL-alpha-Tocopherol-d9 is the deuterium labeled DL-alpha-Tocopherol [1]. DL-alpha-Tocopherol is a synthetic vitamin E, with antioxidation effect. DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB .
|
-
- HY-N1661
-
|
|
Others
|
Others
|
|
2α,3β-Dihydroxypterodontic acid is a natural product used for synthesize 2α,3β-dihydroxy-5,11(13)-dien-eudesman-12-oic acid [1].
|
-
- HY-P3140
-
|
|
α-synuclein
|
Neurological Disease
|
|
α-Synuclein (61-75) is the 61-75 fragment of α-Synuclein. α-Synuclein is an abundant neuronal protein that is highly enriched in presynaptic nerve terminals. α-Synuclein is a potential biomarker for Parkinson's disease (PD) [1] .
|
-
- HY-160027
-
|
|
TNF Receptor
|
Inflammation/Immunology
|
|
TNF-alpha-IN-1 (compound 202) is an orally active inhibitor of TNF-alpha. TNF-alpha-IN-1 has anti-inflammatory activity which can used in study rheumatoid arthritis, psoriasis, and asthma [1].
|
-
- HY-172608
-
|
|
TNF Receptor
|
Inflammation/Immunology
|
|
TNF-α-IN-24 (Example 15) is a TNF-α inhibitor with an IC50 of 4.1 nM. TNF-α-IN-24 can be used in study of inflammatory and autoimmune disorders such as rheumatoid arthritis and Crohn’s disease [1].
|
-
- HY-129113R
-
|
|
Reference Standards
COX
|
Inflammation/Immunology
|
|
α-Chaconine (Standard) is the analytical standard of α-Chaconine. This product is intended for research and analytical applications. α-Chaconine inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects [1].
|
-
- HY-N0728R
-
|
|
Reference Standards
PI3K
Akt
|
Cardiovascular Disease
Cancer
|
|
α-Linolenic acid (Standard) is the analytical standard of α-Linolenic acid. This product is intended for research and analytical applications. α-Linolenic acid, isolated from Perilla frutescens, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer [1].
|
-
- HY-P10616
-
|
|
Endogenous Metabolite
|
Cardiovascular Disease
|
|
Salusin-α is an endogenous bioactive peptide with hemodynamic and cell proliferation activities. Salusin-α can stimulate the proliferation of quiescent vascular smooth muscle cells (VSMCs) and fibroblasts, leading to a rapid and significant decrease in blood pressure and heart rate, but its effect is weaker than that of Salusin-β (HY-P10617). Salusin-α has potential application value in cardiovascular disease research [1].
|
-
- HY-W014118S
-
|
|
Isotope-Labeled Compounds
|
Cancer
|
|
α-Hexylcinnamaldehyde-d5 is deuterated labeled α-Hexylcinnamaldehyde (HY-W014118). α-Hexylcinnamaldehyde, a compound derived from Cinnamaldehyde. α-Hexylcinnamaldehyde has the potential antimutagenic and chemosensitizing properties. α-Hexylcinnamaldehyde is widely used as an ingredient in many personal care, and as an additive in food and the pharmaceutical industry [1].
|
-
- HY-156078
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-32 (compound f26) is a reversible, noncompetitive and orally active α-glucosidase inhibitor with an IC50 value of 3.07 μM. α-Glucosidase-IN-32 complex with α-glucosidase through hydrogen bonds and hydrophobic interactions, led to changes in the conformation and secondary strictures of α-glucosidase and further the inhibition of the enzymatic activity. α-Glucosidase-IN-32 can be used for diabetic disease research [1].
|
-
- HY-168495
-
|
|
Amylases
Glycosidase
|
Metabolic Disease
|
|
α-Amylase-IN-12 (Compound 5e) is an α-amylase inhibitor (IC50: 0.15 mM) with a mixed inhibition. α-Amylase-IN-12 has an IC50 of 9.40 mM against α-glucosidase. α-Amylase-IN-12 promotes glucose uptake in yeast cells and exhibits significant antiglycation activity at high concentrations. α-Amylase-IN-12 can be used for the research of diabetes [1].
|
-
- HY-169283
-
|
|
Carbonic Anhydrase
|
Metabolic Disease
|
|
α-Glycosidase-IN-2 (compound 8b) is a α-Glycosidase inhibitor with the Ki values of 74.16 nM and 6.09 nM for aldose reductase and α-glycosidase,respectively. α-Glycosidase-IN-2 can be used for study of
diabetes mellitus [1].
|
-
- HY-120874
-
|
PF-06372865; CVL-865
|
GABA Receptor
|
Neurological Disease
|
|
Darigabat (PF-06372865) is an orally active, α2/α3/α5 subtype-selective GABAA positive allosteric modulator (PAM). Darigabat is a high affinity ligand at GABAA receptors containing α1/α2/α3/α5 subunits (Kis of 2.9 nM, 21 nM, 134 nM for α2, α1 PAM, α2 PAM, respectively), with low affinity for α4/α6 subunits. Darigabat can across the blood-brain barrier (BBB). Darigabat has anxiolytic activity and has the potential for epilepsy [1].
|
-
- HY-18874
-
|
|
p38 MAPK
Autophagy
|
Others
|
|
p38-α MAPK-IN-1 is an inhibitor of MAPK14 (p38-α), with IC50 of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay [1].
|
-
- HY-W720313
-
|
|
Drug Derivative
|
Neurological Disease
|
|
4-Methyl-α-ethylaminobutiophenone hydrochloride is a para-methyl analog of buphedrone with an ethyl group replacing methyl at the alpha position.
|
-
- HY-U00376
-
-
- HY-137119
-
|
5-iso Prostaglandin F2α-VI
|
Prostaglandin Receptor
|
Others
|
|
(±)5-iPF2α-VI (5-iso Prostaglandin F2α-VI) is the racemate of 5-iPF2α-VI. 5-iPF2α-VI is a regioisomeric isoprostane formed from arachidonic acid (AA) and is a biomarker of oxidative stress [1].
|
-
- HY-171051
-
|
|
DGK
|
Others
|
|
DGKα-IN-9 (example 298) is an inhibitor of DGKα .
|
-
- HY-P1863
-
|
|
Opioid Receptor
|
Neurological Disease
|
|
α-Neoendorphin (1-8) is a 8-amino acid peptide derived from the N-terminal of α-Neoendorphin. α-Neoendorphin is an endogenous opioid peptide.
|
-
- HY-P0252B
-
|
α-Melanocyte-Stimulating Hormone free acid
|
Melanocortin Receptor
|
Neurological Disease
|
|
α-MSH free acid (α-Melanocyte-Stimulating Hormone free acid) is an MC3R and MC4R agonist with EC50s of 0.16 nM and 5.6 nM, respectively. α-MSH free acid activates cAMP generation at MC3R and MC4R [1].
|
-
- HY-N0375R
-
|
|
Reference Standards
Proteasome
NF-κB
Apoptosis
|
Neurological Disease
Inflammation/Immunology
Cancer
|
|
18α-Glycyrrhetinic acid (Standard) is the analytical standard of 18α-Glycyrrhetinic acid. This product is intended for research and analytical applications. 18α-Glycyrrhetinic acid, a diet-derived compound, is an inhibitor of NF-kB and an activator of proteasome, which serves as pro-longevity and anti-aggregation factor in a multicellular organism. 18α-Glycyrrhetinic acid induces apoptosis [1] .
|
-
- HY-174223
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-90 (Compound 7b) is an α-Glucosidase inhibitor (IC50: 14.48 nM). α-Glucosidase-IN-90 binds to HIS:280 and ASN:415 residues of α-glucosidase via hydrogen bonds, inhibiting the activity of the enzyme. α-Glucosidase-IN-90 can be used in the study of diabetes [1].
|
-
- HY-133890AS
-
-
- HY-158571
-
-
- HY-139246
-
-
- HY-170052
-
-
- HY-N2852
-
|
|
Reactive Oxygen Species (ROS)
|
Others
|
|
α-Terthienylmethanol is a terthiophene isolated from the n-hexane fraction of E. prostrata. α-Terthienylmethanol has potent cytotoxic activity against human endometrial cancer cells (Hec1A and Ishikawa) (IC50 < 1 μM). α-Terthienylmethanol increases the intracellular level of ROS and decreases that of GSH [1].
|
-
- HY-120296
-
|
|
Adrenergic Receptor
|
Cardiovascular Disease
|
|
5-Methylurapidil isα1A‐adrenoceptor antagonist. 5-Methylurapidil can be used for the research of cardiovascular diseases such as hypertension and heart failure [1].
|
-
- HY-129434A
-
|
|
Bacterial
|
Infection
|
|
4aα,7α,7aα-Nepetalactone exhibits antibacterial activity, and inhibits Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Salmonella typhi and Enterococcus faecalis.
|
-
- HY-N12135
-
|
|
Others
|
Cancer
|
|
15α-Hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7α(6,11α)-diolide (compound 2) is an enantio-kaurene diterpenoid (ent -kaurene diterpenoid), which can be isolated from Rubescens rubescens. 15α-Hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7α(6,11α)-diolide has cellular activity against EC-1, U87, A549, MCF-7 and HeLa cell lines Toxicity, IC50s are 37.69 μM, 79.362 μM, 80.07 μM, 197.35 μM, 462.13 μM, and 180.09 μM respectively [1].
|
-
- HY-W654353
-
|
T-α-MCA-d4-1 sodium
|
Isotope-Labeled Compounds
FXR
Endogenous Metabolite
|
Others
|
|
Tauro-α-muricholic acid-d4-1 (sodium) is deuterium labeled Tauro-α-muricholic acid (sodium). Tauro-α-muricholic acid (T-α-MCA) sodium is a FXR (Farnesoid X receptor) antagonist (IC50=28μM). Tauro-α-muricholic acid sodium is also a endogenous metabolite that can be found in cecal [1] .
|
-
- HY-153016
-
|
|
HIF/HIF Prolyl-Hydroxylase
|
Inflammation/Immunology
|
|
HIF-2α agonist 2 (compound 10) is a HIF-2α agonist with an EC50 value of 1.68 μM at the dose of 20 μM. HIF-2α agonist 2 is non-cytotoxic against 786-O-HRE-Luc cells. HIF-2α agonist 2 can be used for oxygen metabolism research [1].
|
-
- HY-P1482A
-
|
Mating Factor α TFA
|
Sex Pheromone
|
Cancer
|
|
α-Factor Mating Pheromone, yeast (TFA) is a tridecapeptide secreted by S. cerevisiae α cells via Ste2p receptor [1].
|
-
- HY-N10868
-
|
|
LIM Kinase (LIMK)
|
Cancer
|
|
8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide (compound 3), a sesquiterpene, has anti-LIMK1 activity. 8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide has inhibitory property on cell motility [1].
|
-
- HY-P10222
-
|
|
HIF/HIF Prolyl-Hydroxylase
|
Cancer
|
|
Cyclo CRLLIF is a dual inhibitor for hypoxia inducible factor (HIF) 1 and 2, which disrupts the interaction of both HIF1-α and HIF2-α with HIF1-β, with affinity for HIF1-α and HIF2-α PAS-B domains KD of 14.5 and 10.2 μM, respectively [1].
|
-
- HY-P10221A
-
|
|
HIF/HIF Prolyl-Hydroxylase
|
Cancer
|
|
Cyclo CKLIIF is a dual inhibitor for hypoxia inducible factor (HIF) 1 and 2, which disrupts the interaction of both HIF1-α and HIF2-α with HIF1-β, with affinity for HIF1-α and HIF2-α PAS-B domains KD of 2.6 and 2.2 μM, respectively [1].
|
-
- HY-161265
-
-
- HY-103202A
-
|
|
Adrenergic Receptor
|
Cardiovascular Disease
|
|
SNAP5089 is a selective α1A-adrenoceptor antagonist with over 1700-fold selectivity for the α1A subtype, which may have implications for the treatment of hypertension and benign prostatic hypertrophy. SNAP5089 demonstrates significant receptor affinity compared to other clinical drugs, emphasizing its potential therapeutic advantages. SNAP5089's high affinity aligns with its suitability for conditions where precise α1A modulation is desirable.
|
-
- HY-106720C
-
|
(+)-YM 09538
|
Adrenergic Receptor
|
Others
|
|
(+)-Amosulalol ((+)-YM 09538) is an isomer of Amosulalol (HY-106720), an orally active dual inhibitor of α1/β1-adrenergic receptors. Amosulalol exhibits antihypertensive activity by inhibiting α1-adrenergic receptors. Amosulalol reduces the reflex increase in heart rate and plasma renin activity (PRA) in spontaneously hypertensive rats (SHR) by inhibiting β1-adrenergic receptors.
|
-
- HY-106720B
-
|
(-)-YM 09538
|
Adrenergic Receptor
|
Others
|
|
(-)-Amosulalol ((-)-YM 09538) is an isomer of Amosulalol (HY-106720), an orally active dual inhibitor of α1/β1-adrenergic receptors. Amosulalol exhibits antihypertensive activity by inhibiting α1-adrenergic receptors. Amosulalol reduces the reflex increase in heart rate and plasma renin activity (PRA) in spontaneously hypertensive rats (SHR) by inhibiting β1-adrenergic receptors.
|
-
- HY-146032
-
-
- HY-N10525
-
|
|
Others
|
Others
|
|
3α,4β-Galactotriose is a galactosyl residue [1].
|
-
- HY-170796
-
|
|
Amylases
|
Metabolic Disease
|
|
α-Amylase-IN-11 (compound C5f) is an α-Amylase inhibitor (IC50=0.56 μM) that can reduce the sugar level in vivo. α-Amylase-IN-11 has a moderate inhibitory effect on α-glucosidase (α-glucosidase), with IC50=11.03 μM. α-Amylase-IN-11 can significantly reduce the glucose concentration in a mouse model and has the potential for use in diabetes research [1].
|
-
- HY-N8423
-
|
|
ERK
GSK-3
|
Neurological Disease
Metabolic Disease
|
|
α-Amyrin is a pentacyclic triterpenoid compound with oral activity. α-Amyrin activates the ERK and GSK-3β signaling pathways. α-Amyrin can be used in the study of metabolic syndrome induced by high fructose diet and cognitive dysfunction caused by low cholinergic neurotransmission [1] .
|
-
- HY-N7857
-
|
19(R)-Hydroxy PGF2α
|
Drug Metabolite
|
Metabolic Disease
|
|
19(R)-Hydroxy-prostaglandin F2α (19(R)-hydroxy PGF2α) is an ω-1 hydroxylase metabolite of PGF2α found in human semen. The concentration of 19(R)-Hydroxy-PGFs compounds (F2α and F1α together) in fresh human semen is about 20 μg/mL. 19(R)-Hydroxy-prostaglandin F2α exhibits no activity at the FP receptor of the cat iris sphincter muscle at concentrations up to 1 μM.
|
-
- HY-118517
-
|
(E)-α-Hydroxy tamoxifen; α-OHTAM
|
Drug Metabolite
|
Cancer
|
|
α-Hydroxytamoxifen is a metabolite of tamoxifen, reacts with DNA in the absence of metabolizing enzymes, and causes formation of DNA adducts [1].
|
-
- HY-171297
-
-
- HY-147518
-
|
|
p38 MAPK
|
Inflammation/Immunology
|
|
p38-α MAPK-IN-5 (compound 4e) is a potent p38α inhibitor with IC50s of 0.1 nM, 0.2 nM, 944 nM, 4100 nM for p38α, p38 β, p38γ, p38δ, respectively. p38-α MAPK-IN-5 has anti-inflammatory effect. p38-α MAPK-IN-5 has the potential for asthma and chronic obstructive pulmonary disease (COPD) research [1].
|
-
- HY-N6825R
-
|
|
Reference Standards
TRP Channel
Endogenous Metabolite
|
Neurological Disease
|
|
Hydroxy-α-sanshool (Standard) is the analytical standard of Hydroxy-α-sanshool. This product is intended for research and analytical applications. Hydroxy-α-sanshool is a transient receptor potential ankyrin 1 (TRPA1) and TRP vanilloid 1 (TRPV1) agonist with EC50s of 69 and 1.1 μM, respectively. Hydroxy-α-sanshool can be used for pain research [1] .
|
-
- HY-N5142R
-
|
|
Reference Standards
Bacterial
|
Infection
Inflammation/Immunology
|
|
α-Terpineol (Standard) is the analytical standard of α-Terpineol. This product is intended for research and analytical applications. α-Terpineol is isolated from Eucalyptus globulus Labill, exhibits strong antimicrobial activity against periodontopathic and cariogenic bacteria [1].
α-Terpineol possesses antifungal activity against T. mentagrophytes, and the activity might lead to irreversible cellular disruption .
|
-
- HY-N6710S
-
-
- HY-157489
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-47 (compound 8H) is a non-competitive α-glucosidase (α-glucosidase) inhibitor with IC50 value is 38.2 μM and Ki value is 38.2 μM. α-Glucosidase-IN-47 can be used in diabetes research. [1].
|
-
- HY-148264
-
-
- HY-162364
-
|
|
p38 MAPK
|
Neurological Disease
|
|
p38-α MAPK-IN-7 (compound 4) is a p38α-MAPK inhibitor with an IC50 value of 98.7 nM. p38-α MAPK-IN-7 protects neuronal cells from dexamethasone-induced ROS production [1].
|
-
- HY-W039897R
-
|
α-Methyl-D-mannoside (Standard)
|
Bacterial
Reference Standards
|
Inflammation/Immunology
|
|
Methyl α-D-mannopyranoside (Standard) is the analytical standard of Methyl α-D-mannopyranoside. This product is intended for research and analytical applications. Methyl α-D-mannopyranoside could target macrophages in anti-tuberculosis inhalation therapy[1].
|
-
- HY-P1264F
-
|
|
nAChR
|
Neurological Disease
|
|
α-Bungarotoxin, FITC labeledis the FITC labelled α-Bungarotoxin (HY-P1264). α-Bungarotoxin is a competitive antagonist at nicotinic acetylcholine receptors (nAChRs) [1].
|
-
- HY-E70039
-
|
|
Others
|
Others
|
|
alpha-2-3,6,8-Sialidosidase (SpNanA) catalyses hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates [1].
|
-
- HY-P2988A
-
|
|
Influenza Virus
|
Metabolic Disease
|
|
α2-3,6 Neuraminidase, Bifidobacterium infantis is a highly specific exoglycosidase that catalyzes the hydrolysis of non-reducing terminal α2-3 and α2-6 unbranched sialic acid residues from complex carbohydrates and glycoproteins. α2-3,6 Neuraminidase does not exhibit activity on α2-8 or branched sialic acids [1].
|
-
- HY-W048231
-
|
4-Methoxyphenyl Alpha-D-Mannopyranoside
|
Biochemical Assay Reagents
|
Others
|
|
4-Methoxyphenyl α-D-mannopyranoside (4-Methoxyphenyl alpha-D-Mannopyranoside) is used in glycobiology research.
|
-
- HY-107641
-
|
α-Cyano-4-hydroxycinnamate
|
Monocarboxylate Transporter
|
Metabolic Disease
|
|
α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamate) is a potent and non-competitive inhibitor of monocarboxylate transporters (MCTs). α-Cyano-4-hydroxycinnamic acid inhibits mitochondrial pyruvate transporter with a Ki of 6.3 μM. α-Cyano-4-hydroxycinnamic acid is used as a matrix to facilitate peptide ionization in matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry applications [1] .
|
-
- HY-137878
-
|
PNP-α-NeuNAc
|
Endogenous Metabolite
|
Others
|
|
2-O-(p-Nitrophenyl)-α-D-N-acetylneuraminic acid (PNP-α-NeuNAc) acts as a sialyl donor in the process of enzyme-catalyzed trans-sialylation.
|
-
- HY-118714
-
|
U 40125; Alpha-Hydroxyalprazolam
|
Drug Metabolite
|
Neurological Disease
|
|
α-Hydroxy alprazolam (U 40125) is a main metabolite of Alprazolam. α-Hydroxy alprazolam is pharmacologically active accounting for 60% of the activity of Alprazolam [1].
|
-
- HY-164159
-
-
- HY-N8531
-
|
|
Drug Derivative
|
Others
|
|
4α-Methylcholesterol is a Cholesterol derivative. 4α-Methylcholesterol can oxidize 3-hydroxy steroid, with the apparent Km of 12.6 μM [1] .
|
-
- HY-N2408
-
|
Isophorbol; α-Phorbol
|
Others
|
Others
|
|
4α-Phorbol is a compound that can be isolated from croton oil [1].
|
-
- HY-107935
-
|
Fluprednisolone
|
Biochemical Assay Reagents
|
Inflammation/Immunology
|
|
6α-Fluoroprednisolone (Fluprednisolone) is an internal standard for methylprednisolone, prednisolone and prednisone. 6α-Fluoroprednisolone is an anti-inflammatory agent. 6α-Fluoroprednisolone can be used for congenital adrenal virilism and Addison's disease research [1] .
|
-
- HY-B0445B
-
|
α-Nicotinamide Adenine Dinucleotide
|
Others
|
Others
|
|
α-NAD (α-Nicotinamide Adenine Dinucleotide) serves as a substrate for renalase and functions as an analog of β-NAD, influencing the kinetics of NAD-dependent enzymes, while also playing a crucial role as a cofactor in mitochondrial oxidation-reduction reactions.
|
-
- HY-161522
-
|
|
Glycosidase
Carbonic Anhydrase
|
Endocrinology
|
|
α-Glucosidase-IN-63 (Compound 4d) is an inhibitor of α-Glucosidase (IC50=0.44 μM). α-Glucosidase-IN-63 inhibits hCA II with an activity of Ki= 7.0 nM. α-Glucosidase-IN-63 is orally effective. [1].
|
-
- HY-N7264S
-
|
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
|
7α-Hydroxycholesterol-d7 is the deuterium labeled 7α-Hydroxycholesterol. 7α-Hydroxycholesterol is a cholesterol oxide and is formed by both enzymatic and non-enzymatic oxidation. 7α-Hydroxycholesterol can be used as a biomarker for lipid peroxidation [1] .
|
-
- HY-148575
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-23 is an orally active α-Glucosidase inhibitor. α-Glucosidase-IN-23 decreases blood glucose by a-glucosidase inhibition with an IC50 value of 4.48 μM. α-Glucosidase-IN-23 can be used for the research of diabetes [1].
|
-
- HY-136735
-
|
|
IRE1
|
Neurological Disease
Cancer
|
|
IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC50 of 77 nM. IRE1α kinase-IN-1 displays 100-fold selectivity for IRE1α over the IRE1β isoform. IRE1α kinase-IN-1 inhibits ER stress-induced IRE1α oligomerization and autophosphorylation, and also inhibits IRE1α RNase activity (IC50=80 nM) [1].
|
-
- HY-149341
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-28 (Compound 18) is a α-Glucosidase inhibitor (IC50: 0.62 μM, Ki: 3.93 μM). α-Glucosidase-IN-28 binds to α-glucosidase at the original binding site (OBS), and forms multiple hydrophobic interactions with nearby amino acids. α-Glucosidase-IN-28 can be used for research of diabetes and related diseases [1].
|
-
- HY-138097
-
|
|
Chemerin Receptor
Aldehyde Dehydrogenase (ALDH)
Cholinesterase (ChE)
Apoptosis
|
Cancer
|
|
α-NETA is a potent and noncompetitive choline acetyltransferase (ChA) inhibitor with an IC50 of 9 μM. α-NETA is a potent ALDH1A1 (IC50=0.04 µM) and chemokine-like receptor-1 (CMKLR1) antagonist. α-NETA weakly inhibits cholinesterase (ChE; IC50=84 µM) and acetylcholinesterase (AChE; IC50=300 µM). α-NETA has anti-cancer activity [1] .
|
-
- HY-P3659
-
-
- HY-132649S
-
-
- HY-134670S1
-
-
- HY-162287
-
-
- HY-Y0245S
-
-
- HY-162286
-
-
- HY-N15019
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Glycothiohexide α is a peptide antibiotic. Glycothiohexide α has strong activity against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin resistant enterococcus (VREF), MIC values of 0.03-0.06 μg/mL [1].
|
-
- HY-116008
-
|
8-epi PGF3α; 8-iso PGF3α
|
Prostaglandin Receptor
|
Endocrinology
|
|
8-iso PGF3α is an isoprostane produced from the free-radical peroxidation of EPA. Little is known about the biological activity of 8-iso PGF3α. There is one report that it is inactive in a TP receptor mediated assay of human platelet shape change, where 8-iso PGF2α has an ED50 value of 1 μM.
|
-
- HY-N5142S1
-
|
|
Bacterial
Isotope-Labeled Compounds
|
Infection
|
|
α-Terpineol-d6 is deuterated labeled α-Terpineol (HY-N5142). α-Terpineol (with oral activity) can be found in Eucalyptus globulus Labill. α-Terpineol exhibits strong antimicrobial activity against periodontopathic and cariogenic bacteria.α-Terpineol possesses antifungal activity against T. mentagrophytes, and the activity might lead to irreversible cellular disruption. In addition, α-Terpineol exhibits antineuropathic and anti-inflammatory activities.
α-Terpineol can be utilized in research related to diarrhea, neuropathic pain, infections, and inflammation [1] .
|
-
- HY-148616
-
-
- HY-168814
-
-
- HY-W708286
-
-
- HY-N7136R
-
|
|
Reference Standards
Cytochrome P450
|
Metabolic Disease
|
|
α-Terpinyl acetate (Standard) is the analytical standard of α-Terpinyl acetate. This product is intended for research and analytical applications. α-Terpinyl acetate is a monoterpene ester isolated from Laurus nobilis L. essential oil. α-Terpinyl acetate is a competitive P450 2B6 substrate which binding to the active site of P450 2B6 with a Kd value of 5.4 μM [1] .
|
-
- HY-N0728
-
|
|
PI3K
Akt
|
Cardiovascular Disease
Cancer
|
|
α-Linolenic acid, isolated from Perilla frutescens, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer [1].
|
-
- HY-N11512
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-24 (Compound 13) is an α-Glucosidase inhibitor with an IC50 of 451 μM. α-Glucosidase-IN-24 can be isolated from Swertia kouitchensis [1].
|
-
- HY-155372
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-39 is a potent inhibitor of α-glucosidase enzyme with an IC50 of 869.06 ppm. α-Glucosidase-IN-39 can used in study antidiabetic [1].
|
-
- HY-115978
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-2 (compound 5d) is a potent α-Glucosidase inhibitor with an IC50 of 9.48 µM. α-Glucosidase-IN-2 is an antidiabetic agent [1].
|
-
- HY-27787
-
|
cis-Eleostearic acid
|
Apoptosis
Ferroptosis
|
Metabolic Disease
Cancer
|
|
α-Eleostearic acid (cis-Eleostearic acid), a conjugated linolenic acid, is an apoptosis inducer. α-Eleostearic acid is also a ferroptosis inducer. α-Eleostearic acid exhibits antioxidant and antitumor activity [1] .
|
-
- HY-161782
-
|
|
Amylases
|
Metabolic Disease
|
|
α-Amylase-IN-7 (Compound 6e) is an inhibitor for α-Amylase with an IC50 of 40 μM. α-Amylase-IN-7 exhibits potential as an antidiabetic agent [1].
|
-
- HY-E70154
-
|
EC:2.4.1.65; FUT3; FT3B
|
Glycosyltransferase
|
Others
|
|
Fucosyltransferase 3 (EC:2.4.1.65, FUT3, FT3B) has strong alpha 1-3 and alpha 1-4 fucosyltransferase activities [1].
|
-
- HY-106554
-
|
|
Adrenergic Receptor
|
Cardiovascular Disease
|
|
Trimazosin is an orally active, quinazoline derivative which is structurally related to prazosin. Trimazosin shows hypotensive effect by selectively block α1-adrenoceptors [1] .
|
-
- HY-117379
-
|
|
Adrenergic Receptor
|
Others
|
|
CHIR-2279 is a high-affinity ligand (Ki=5 nM) for the α1-adrenergic receptor and can be further studied as a drug lead compound [1].
|
-
- HY-B0769R
-
-
- HY-161999
-
|
|
Glycosidase
|
Metabolic Disease
Inflammation/Immunology
|
|
α-Glucosidase-IN-73 (compound 16b) is an α-Glucosidase inhibitor with IC50 of 0.158 μM. α-Glucosidase-IN-73 can activate PPAR γ. α-Glucosidase-IN-73 can be used in anti-diabetic and anti-inflammatory studies [1].
|
-
- HY-W089785
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Methyl α-D-galactopyranoside monohydrate is an alpha-D-galactoside having a methyl substituent at the anomeric position. Methyl α-D-galactopyranoside inhibits debaryomyces hansenii UFV-1 extracellular and intracellular α-galactosidases with Ki values of 0.82 and 1.12 mM, respectively [1].
|
-
- HY-W751152R
-
|
|
Others
Reference Standards
|
Cancer
|
|
α,β-Thujone (Standard) is the analytical standard of α,β-Thujone. This product is intended for research and analytical applications. α,β-Thujone is a component of the essential oils of some plants. α,β-Thujone causes cancers in male rats and induces seizures in the highest doses [1].
|
-
- HY-163066
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-44 (compound IT4) is an inhibitor of α-glucosidase with IC50 value of 2.35 μM. α-Glucosidase-IN-44 has an oral activity. α-Glucosidase-IN-44 suppresses fasting blood glucose levels in diabetic mice [1].
|
-
- HY-106029
-
|
α-TPA
|
PKC
SphK
NF-κB
|
Cancer
|
|
4α-TPA is an inactive form of TPA, and is used as a negative control for TPA-activated events [1].
|
-
- HY-133970R
-
|
|
Biochemical Assay Reagents
Reference Standards
|
Others
|
|
5α-Cholestane (Standard) is the analytical standard of 5α-Cholestane. This product is intended for research and analytical applications. 5α-Cholestane is a biochemical reagent that can be used as a biological material or organic compound for life science related research [1].
|
-
- HY-164102
-
|
|
TNF Receptor
NF-κB
|
Inflammation/Immunology
|
|
TNF-α-IN-18 (Compound 61) is an inhibitor for TNF-α (IC50 of 1.8 μM), that inhibits TNF signaling pathway through block of NF-kB migration from cytoplasm to nucleus. TNF-α-IN-18 exhibits slight cytotoxicity to mouse fibroblast LM cell, with a CC50 >50 μM. TNF-α-IN-18 ameliorates the TNF- or Lipopolysaccharide (HY-D1056)-induced sepsis in mouse models. TNF-α-IN-18 protects mice from rheumatoid arthritis [1].
|
-
- HY-D1632
-
|
|
Fluorescent Dye
|
Others
|
|
4-MU-α-GlcNS sodium is a fluorogenic substrate of heparin sulphamidase, is desulfurized into 4-MU-α-GlcNH2. 4-MU-α-GlcNH2 can liberate 4-methylumbelliferone (4-MU, fluorescent product) via α-glucosaminidase catalysis, with the emission wavelength maxima of 445-454 nm. 4-MU-α-GlcNS sodium can be used to heparin sulphamidase deficiencies associated with Mucopolisaccaridosis IIIA and other lysosomal disorders researches [1] .
|
-
- HY-P0297
-
-
- HY-149579
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-36 (compound 5g) is a potent α-glucosidase inhibitor, with an IC50 of 6.69 ± 0.18 μM, Ki and Kis of 1.65 μM and 4.54 μM, respectively. α-Glucosidase-IN-36 may inhibit α-glucosidase activity by binding with its active site as well as changing the secondary structure of α-glucosidase. α-Glucosidase-IN-36 can be used for type 2 diabetes mellitus (T2DM) research [1].
|
-
- HY-N6710
-
|
|
Estrogen Receptor/ERR
|
Inflammation/Immunology
|
|
α-Zearalenol is a Mycotoxin with high affinity for the estrogen receptors (ER),
α-Zearalenol is the derivative of zearalenone (ZEN), causes reproductive disorders in animals, due to its xenoestrogenic effects [1].
|
-
- HY-W587956
-
|
|
Fungal
|
Infection
|
|
α-Guaiene is a sesquiterpene that could be found in Pogostemon cablin. α-Guaiene is the predominant component of patchouli essential oil, which exhibits antifungal activity against Aspergillus species [1].
|
-
- HY-W741922
-
-
- HY-128417S
-
-
- HY-161293
-
|
|
p38 MAPK
|
Cancer
|
|
p38-α MAPK-IN-6 (compound 3a) is a p38α mitogen-activated protein kinase inhibitor [1].
|
-
- HY-169870
-
|
(+)-Mecamylamine; TC-5214
|
nAChR
|
Neurological Disease
|
|
Dexmecamylamine ((+)-Mecamylamine) is the antagonist for nicotinic acetylcholine receptor (nAChR), that antagonises the α3β4/α4β2/α7/α1β1γδ receptor with IC50 of micromolare levels. Dexmecamylamine exhibits anxiolytic and antidepressant-like activities [1].
|
-
- HY-W783267
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-35 (compound 1) is a kind of chromene. α-Glucosidase-IN-35 can be isolated from the aqueous extract of the aerial parts of Brickellia cavanillesii. α-Glucosidase-IN-35 is a potent inhibitor of α-glucosidase with an IC50 value of 0.169 mg/mL [1].
|
-
- HY-W766497
-
|
|
Isotope-Labeled Compounds
Estrogen Receptor/ERR
|
Inflammation/Immunology
|
|
Alpha-Zearalenol-d7 is the deuterium labeled α-Zearalenol (HY-N6710). α-Zearalenol is a Mycotoxin with high affinity for the estrogen receptors (ER). α-Zearalenol is the derivative of zearalenone (ZEN), causes reproductive disorders in animals, due to its xenoestrogenic effects [1].
|
-
- HY-N2843
-
|
|
Others
|
Inflammation/Immunology
|
|
α-Amyrin palmitate is isolated from Santalum album (sandalwood). α-Amyrin palmitate can be used for the study of arthritis in vivo [1].
|
-
- HY-147823
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-6 (compound 18) is a competitive α-glucosidase inhibitor with an IC50 of 5.69 µM. α-Glucosidase-IN-6 has anti-diabetic potential [1].
|
-
- HY-170866
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-81 (Compound 5) is a potent α-Glucosidase inhibitor with an IC50 value of 5.30 μM. α-Glucosidase-IN-81 is promising for research of diabetes [1].
|
-
- HY-157488
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-46 is a potent α-glucosidase inhibitor with an IC50 of 26.0 μM. α-Glucosidase-IN-46 can be used for the research of type 2 diabetes [1].
|
-
- HY-161318
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-52 (Compound 3h) is an α-glucosidase inhibitor with an IC50 of 2.8 μM. α-Glucosidase-IN-52 can be used for diabetes research [1].
|
-
- HY-120408
-
|
Atroscine
|
Adrenergic Receptor
|
Neurological Disease
|
|
(±)-Scopolamine (Atroscine) is the racemic modification of Scopolamine. (±)-Scopolamine inhibits α-adrenergic receptor activity. (±)-Scopolamine has Ki values of 33 μM and 7.25 nM for α1-adrenerg receptor and muscarinic cholinergic receptor, respectively [1].
|
-
- HY-125833R
-
|
|
Cytochrome P450
Aryl Hydrocarbon Receptor
Apoptosis
|
Cancer
|
|
Alpha-Naphthoflavone (Standard) is the analytical standard of Alpha-Naphthoflavone. This product is intended for research and analytical applications. Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis [1] .
|
-
- HY-172100
-
|
|
Apoptosis
Reactive Oxygen Species (ROS)
p38 MAPK
|
Cancer
|
|
p38-α MAPK-IN-8 (Compound 13) is a lipophilic cationic derivative. p38-α MAPK-IN-8 is cytotoxic to various tumor cells, and can induce cell cycle arrest, apoptosis, increase reactive oxygen species (ROS) production, and induce mitochondrial membrane potential depolarization. The antitumor activity of p38-α MAPK-IN-8 may be related to p38α MAPK pathway, which can be used in the study of cancer [1].
|
-
- HY-156435
-
|
|
α-synuclein
|
Neurological Disease
|
|
tau protein/α-synuclein-IN-1 is a dual inhibitor of tau protein and α-synuclein. tau protein/α-synuclein-IN-1 reduces α-syn inclusions development in M17D neuroblastoma cells. tau protein/α-synuclein-IN-1 can be used in study Alzheimer’s disease [1].
|
-
- HY-134460
-
|
|
Endogenous Metabolite
|
Others
|
|
4-Methylumbelliferyl α-L-fucopyranoside is an α-L-fucosidase. α-L-fucosidase can enhance capacitation of porcine sperm and protect sperm from premature acrosome reaction. Compared with human liver α-L-fucosidase, 4-Methylumbelliferyl α-L-fucopyranoside has considerable hydrophobicity and isoelectric focusing properties [1] .
|
-
- HY-P5044
-
|
|
α-synuclein
|
Neurological Disease
|
|
α-Synuclein (45-54) (human) is the 45-54 fragment of α-Synuclein. α-Synuclein is an abundant neuronal protein that is highly abundant in presynaptic nerve terminals. α-Synuclein is a biomarker for Parkinson's disease (PD) [1].
|
-
- HY-P5041
-
|
|
α-synuclein
|
Neurological Disease
|
|
α-Synuclein (34-45) (human) is the 34-45 fragment of α-Synuclein. α-Synuclein is an abundant neuronal protein that is highly abundant in presynaptic nerve terminals. α-Synuclein is a Parkinson's disease (PD) biomarker [1].
|
-
- HY-P5046
-
|
|
α-synuclein
|
Neurological Disease
|
|
α-Synuclein (71-82) (human) is the 71-82 fragment of α-Synuclein. α-Synuclein is an abundant neuronal protein that is highly abundant in presynaptic nerve terminals. α-Synuclein is a biomarker for Parkinson's disease (PD) [1].
|
-
- HY-P5681
-
|
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
Human α-Defensin 6, a 32-residue cysteine-rich peptide, can inhibit bacterial invasion and contribute to the mucosal immunity. Human α-Defensin 6 forms ordered self-assembly fibrils and nanonets that surround and entangle bacteria after stochastic binding to bacterial surface proteins. Human α-Defensin 6 also inhibits C. albicans biofilm formation [1] .
|
-
- HY-129113
-
|
|
COX
|
Inflammation/Immunology
|
|
α-Chaconine inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects [1].
|
-
- HY-149676
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-42 (Compound 26) is a 9-O-berberrubine carboxylate derivative. α-Glucosidase-IN-42 has potent α-glucosidase inhibitory activities with an IC50 value in the range of 1.61 μM. α-Glucosidase-IN-42 can be used for the research of antidiabetic [1].
|
-
- HY-149886
-
|
|
HIF/HIF Prolyl-Hydroxylase
|
Cancer
|
|
HIF-2α-IN-9 (compound 35r) is an inhibitor ofHIF-2α. HIF-2α-IN-9 inhibits VEGF-A (IC50=305 nM), and regulates growth-promoting genes in tumor cells, reactivates macrophage-mediated tumor immunity [1].
|
-
- HY-128417S1
-
-
- HY-128417S3
-
-
- HY-121573
-
|
|
Biochemical Assay Reagents
|
Cardiovascular Disease
|
|
α-Acetyldigoxin can be used in heart failure related research and is orally available. The bioavailability of α-Acetyldigoxin is lower than that of β-Acetyldigoxin when administered orally and intravenously [1].
|
-
- HY-113462
-
|
|
Others
|
Cancer
|
|
α-Carotene, a precursor of vitamin A, is used as an anti-metastatic agent or as an adjuvant for anti-cancer agents. α-Carotene is isolated from yellow-orange and dark-green vegetables [1] .
|
-
- HY-130325
-
|
|
NO Synthase
|
Neurological Disease
|
|
α-Guanidinoglutaric acid is a guanidino compound first found in cobaltinduced epileptogenic focus tissue in the cerebral cortex of cats. α-Guanidinoglutaric acid induces epileptic seizures in rats after intraventricular administration [1].
|
-
- HY-N7932
-
|
|
Others
|
Others
|
|
Kaempferol 3-O-α-L-rhamnopyranosyl(2,1)-α-L-rhamnopyranoside (compound 23) is a flavonoid isolated from the whole herb of E. wushanense [1].
|
-
- HY-151892S
-
-
- HY-147718
-
|
|
Glutaminase
|
Metabolic Disease
|
|
α-Glucosidase-IN-5 (compound 8) is a potent α-glucosidase inhibitor with an IC50 of 57.9 µM. α-Glucosidase-IN-5 has the potential for the research of diabetes mellitus [1].
|
-
- HY-19949
-
-
- HY-151142
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-18 (7B) is an orally active α-glucosidase inhibitor with an IC50 value of 3.96 μM. α-Glucosidase-IN-18 has antidiabetic activity [1].
|
-
- HY-146984
-
|
|
Glycosidase
|
Inflammation/Immunology
|
|
α-Glucosidase-IN-3 is an oleanolic acid (OA) oxime ester derivative against α-glucosidase (IC50=1.28 µM) and α-amylase (IC50=3.8 µM) .
|
-
- HY-N6602R
-
-
- HY-107826
-
-
- HY-137504
-
-
- HY-126025
-
-
- HY-142708
-
-
- HY-W145656S
-
-
- HY-130437
-
|
|
MDM-2/p53
TGF-β Receptor
Caspase
|
Infection
Metabolic Disease
|
|
p-nitro-Pifithrin-α, a cell-permeable analog of pifithrin-α, is a potent p53 inhibitor. p-nitro-Pifithrin-α suppresses p53-mediated TGF-β1 expression in HK-2 cells. p-nitro-Pifithrin-α inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice fed a high-fat diet [4].
non-alcoholic fatty liver disease [1] .
|
-
- HY-163519
-
|
|
α-synuclein
|
Neurological Disease
|
|
α-Synuclein inhibitor 13 is an inhibitor of α-synuclein (α-Syn). α-Synuclein inhibitor 13 inhibits the aggregation of α-Syn proteins and is able to break down formed fibers. It is mainly used in Parkinson's disease research [1].
|
-
- HY-106612
-
|
U-K52046; Albanoquil
|
Adrenergic Receptor
|
Cardiovascular Disease
|
|
Abanoquil (U-K52046), an potent and selective α-1 adrenoceptor antagonist, is an anti-arrhythmic agent. Abanoquil can be used for erectile dysfunction research [1] .
|
-
- HY-12749B
-
|
|
Others
|
Cardiovascular Disease
|
|
(R)-Midodrine hydrochloride is a vasopressor used as an antihypertensive agent for the treatment of symptomatic postural hypotension, exhibiting peripheral alpha(1)-adrenoreceptor agonistic activity that induces venous and arterial vasoconstriction.
|
-
- HY-106554A
-
|
|
Adrenergic Receptor
|
Cardiovascular Disease
|
|
Trimazosin hydrochloride hydrate is an orally active, quinazoline derivative which is structurally related to prazosin. Trimazosin shows hypotensive effect by selectively block α1-adrenergic receptor [1] .
|
-
- HY-133970S
-
-
- HY-133970S1
-
-
- HY-118566S
-
-
- HY-B1278BR
-
|
(±)-Vitamin E acetate (Standard)
|
Biochemical Assay Reagents
Reference Standards
|
Infection
|
|
(±)-α-Tocopherol acetate (Standard) is the analytical standard of (±)-α-Tocopherol acetate. This product is intended for research and analytical applications. (±)-α-Tocopherol acetate ((±)-Vitamin E acetate), is a orally active synthetic form of vitamin E. (±)-α-Tocopherol acetate is the ester of acetic acid and α-tocopherol. (±)-α-Tocopherol acetate can be used for the research of the susceptibility of farmed fish to infectious diseases [1].
|
-
- HY-16686
-
|
Alpha-Tocopherol phosphate; TocP; vitamin E phosphate
|
Apoptosis
Reactive Oxygen Species (ROS)
|
Cancer
|
|
α-Tocopherol phosphate is an antioxidant that protects against long-wave UVA1 induced cell death and scavenge UVA1 induced ROS in a skin cell model. α-Tocopherol phosphate exhibits angiogenesis-promoting activity [1] .
|
-
- HY-W746888
-
|
17-p-PGF2α-NEt2; 17-Phenyl trinor PGF2α diethyl amide
|
Prostaglandin Receptor
|
Cardiovascular Disease
|
|
17-Phenyl trinor prostaglandin F2α diethyl amide (17-phenyl trinor PGF2α diethyl amide) is a PGF2α analog with hypotensive efficacy [1].
|
-
- HY-W086896R
-
|
|
Reference Standards
Drug Metabolite
|
Inflammation/Immunology
|
|
α-Demethylnaproxen (Standard) is the analytical standard of α-Demethylnaproxen. This product is intended for research and analytical applications. α-Demethylnaproxen is the major metabolite of Nabumetone (HY-B0559), Nabumetone is an orally active COX-2 inhibitor with anti-inflammatory activity [1] .
|
-
- HY-P1253
-
|
|
Opioid Receptor
|
Neurological Disease
|
|
α-Endorphin (human) is a neuropeptide, that acts on the central nervous system (CNS) and peripheral nervous system (PNS). α-Endorphin (human) binds μ-opioid receptor, and exhibits analgesic efficacy. α-Endorphin (human) regulates sexual behaviors and pleasure felling [1].
|
-
- HY-151135
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-15 (Compound 14B) is a potent, orally active α-glucosidase inhibitor with an IC50 of 3.34 μM. α-Glucosidase-IN-15 shows antidiabetic activity [1].
|
-
- HY-147964
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-9 (compound 7) is a potent α-glucosidase inhibitor, with an IC50 of 55.6 μM. α-Glucosidase-IN-9 can be used for type II diabetes research [1].
|
-
- HY-147965
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-10 (compound 13) is a potent α-glucosidase inhibitor, with an IC50 of 92.7 μM. α-Glucosidase-IN-10 can be used for type II diabetes research [1].
|
-
- HY-151141
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-17 (Compound 12B) is a potent, orally active α-glucosidase inhibitor with an IC50 of 3.79 μM. α-Glucosidase-IN-17 shows antidiabetic activity [1].
|
-
- HY-P2965
-
|
|
Endogenous Metabolite
|
Cancer
|
|
L-Lysine α-oxidase is a potent anticancer agent. L-Lysine α-oxidase also a L-amino acid oxidase, deaminates L-lysine with the yield of H2O2, ammonia, and α-keto-ε-aminocaproate. L-Lysine α-oxidase shows cytotoxicity and anticancer activity [1] .
|
-
- HY-P5082
-
|
|
α-synuclein
|
Neurological Disease
|
|
α-Synuclein 4554W is an inhibitor of α-Synuclein (aSyn) aggregation with associated toxicity. α-Synuclein 4554W consists of GIVNGVKA sequences, previously identified through intracellular library screening. α-Synuclein 4554W reduces fibril formation of aSyn mutants assocaited with Parkinson’s disease [1].
|
-
- HY-W020044S
-
|
|
Isotope-Labeled Compounds
Ferroptosis
|
Others
|
|
DL-alpha-Tocopherol- 13C3 is the 13C-labeled DL-alpha-Tocopherol. DL-alpha-Tocopherol is a synthetic vitamin E, with antioxidation effect. DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB [1].
|
-
- HY-P3140A
-
|
|
α-synuclein
|
Neurological Disease
|
|
α-Synuclein (61-75) TFA is the 61-75 fragment of α-Synuclein. α-Synuclein is an abundant neuronal protein that is highly enriched in presynaptic nerve terminals. α-Synuclein is a potential biomarker for Parkinson's disease (PD) [1] .
|
-
- HY-173130
-
|
|
Glycosidase
|
Metabolic Disease
Inflammation/Immunology
|
|
α-Glucosidase-IN-86 (Compound A4) is an orally active α-glucosidase inhibitor with an IC50 of 2.72 μM. α-Glucosidase-IN-86 has high safety in mice. α-Glucosidase-IN-86 can reduce fasting blood glucose levels, improve glucose tolerance, regulate blood lipids, and has antioxidant effects in diabetic mice. α-Glucosidase-IN-86 can be used for the research of diabetes [1].
|
-
- HY-N2849
-
|
(+)-Onocerin; α-Onocerin
|
Others
|
Others
|
|
alpha-Onocerol ((+)-Onocerin) is a Alkaloids product that can be isolated from the roots of Stephania japonica. [1].
|
-
- HY-P1875A
-
-
- HY-P1825A
-
-
- HY-D2360
-
|
|
HIF/HIF Prolyl-Hydroxylase
HSP
|
Cancer
|
|
O-Carboranylphenoxyacetanilide is a HIF-1α inhibitor and inhibits HIF-1α activation. O-Carboranylphenoxyacetanilide inhibits transcriptional activity of HIF in HeLa cells (IC50: 0.74 μM). O-Carboranylphenoxyacetanilide inhibits HSP60 chaperone activity and HSP60 ATPase activity [1].
|
-
- HY-N15090
-
-
- HY-W020035
-
|
|
GPR55
|
Neurological Disease
|
|
L-α-lysophosphatidylinositol Soy sodium is an endogenous ligand of GPR55. L-α-lysophosphatidylinositol Soy sodium is an endogenous lysophospholipid and endocannabinoid neurotransmitter that belongs to the class of lysophospholipids [1].
|
-
- HY-E70103
-
|
|
Glycosidase
|
Others
|
|
α-L-Arabinofuranosidase is a glycosidic hydrolase. α-L-Arabinofuranosidase hydrolyse the nonreducing termini of the a-l-arabinofuranosyl residues as side chains of arabinoxylan, arabinan and arabinogalactan [1].
|
-
- HY-115433S
-
-
- HY-115433S1
-
-
- HY-P3645
-
|
|
Melanocortin Receptor
|
Others
|
|
(Nle4)-α-MSH is a synthetic analogue of α-MSH (HY-P0252), a melanocyte-stimulating hormone. (Nle4)-α-MSH reversibly darkens frog skins and also exhibits prolonged activity after heat-alkali treatment [1].
|
-
- HY-W020182
-
|
Terpilene
|
Fungal
Parasite
|
Infection
|
|
α-Terpinene (Terpilene) is a monoterpene found in the essential oils of a large variety of foods and aromatic plants such as Mentha piperita. α-Terpinene is active against Trypanosoma evansi and has the potential for trypanosomosis treatment. α-Terpinene has antioxidant and antifungal properties [1] .
|
-
- HY-151143
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-19 (Compound 6B) is a potent, orally active α-glucosidase inhibitor with an IC50 of 3.63 μM. α-Glucosidase-IN-19 shows anti-diabetic activity [1].
|
-
- HY-N12664
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-54 (compound 2) is a α-glucosidase inhibitor with the IC50 of 0.011 mM, and can be isolated form Syzygium jambos (L.). α-Glucosidase-IN-54 can be used for study of diabetes [1].
|
-
- HY-161944
-
|
|
Amylases
|
Metabolic Disease
|
|
α-Amylase-IN-8 (compound 44) is an α-amylase inhibitor (IC50=58.1 μM). α-Amylase-IN-8 can be used in the research of type 2 diabetes [1].
|
-
- HY-157311
-
|
|
Glycosidase
|
Cancer
|
|
α-Glucosidase-IN-45 (compound 11E) is an inhibitor of α-glucosidase. α-Glucosidase-IN-45 is a novel indol-fused pyrano[2,3-D]pyrimidine compound [1].
|
-
- HY-169251
-
-
- HY-170548
-
|
|
Amylases
|
Metabolic Disease
|
|
α-Amylase-IN-10 (Compound 15n) is an inhibitor for α-Amylase with an IC50 of 5.00 µM. α-Amylase-IN-10 can be used for research of type 2 diabetes mellitus [1].
|
-
- HY-158697
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-65 (compound 5) is a Schiff base derivative of 3,4-dihydroxyphenylacetic acid. α-Glucosidase-IN-65 is a potent α-glucosidase inhibitor, with an IC50 of 12.84 μM [1].
|
-
- HY-173035
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-85 (Compound 8D1) is the inhibitor for α-Glucosidase with an IC50 of 5.43 μM. α-Glucosidase-IN-85 can be used in research of type 2 diabetes [1].
|
-
- HY-151145
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-21 (Compound 2B) is a potent, orally active α-glucosidase inhibitor with an IC50 of 2.62 μM. α-Glucosidase-IN-21 shows anti-diabetic activity [1].
|
-
- HY-151144
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-20 (Compound 3B) is a potent, orally active α-glucosidase inhibitor with an IC50 of 3.01 μM. α-Glucosidase-IN-20 shows anti-diabetic activity [1].
|
-
- HY-157537
-
-
- HY-146752
-
|
|
Amylases
|
Others
|
|
α-Amylase-IN-1 is a potent α-amylase inhibitor with an IC50 of 4.46 μM [1].
|
-
- HY-N3037
-
-
- HY-N3706
-
|
|
Fungal
|
Infection
|
|
Dehydro-α-lapachone can be isolated from the methanol extract of stems of Catalpa ovata G Don. Dehydro-α-lapachone inhibits mycelial growth of Botrytis cinerea with IC50 value 0.41 mg/L [1].
|
-
- HY-N3363
-
|
20(29)-Lupene-2α,3β-diol; 2α,3β-Dihydroxylup-20(29)-ene
|
Others
|
Others
|
|
Lup-20(29)-ene-2alpha,3beta-diol (20(29)-Lupene-2α,3β-diol) is a phenol product that can be isolated from Chinese bog bilberry wines [1].
|
-
- HY-148908
-
|
|
TNF Receptor
|
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
|
TNF-α-IN-8 (compound I-42) is a TNF-α inhibitor. TNF-α-IN-8 is an isoindole-imide compound. TNF-α-IN-8 can be used for the research of cancer, heart disease, osteoporosis, inflammatory, allergic and autoimmune diseases [1]. TNF-α-IN-8 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-125457
-
|
p-Naphtolbenzein
|
Fluorescent Dye
|
Others
|
|
α-Naphtholbenzein (p-Naphtolbenzein) is a dye. α-Naphtholbenzein can be used as a pH indicator. α-Naphtholbenzein has a visual transition from yellow (pH0-8.2) to turquoise (pH10). α-Naphtholbenzein is often used during sequential injection analysis technique done for acid-base titrations [1].
|
-
- HY-N5142S
-
|
|
Bacterial
|
Infection
|
|
α-Terpineol-d3 is the deuterium labeled α-Terpineol [1]. α-Terpineol is isolated from Eucalyptus globulus Labill, exhibits strong antimicrobial activity against periodontopathic and cariogenic bacteria [2].α-Terpineol possesses antifungal activity against T. mentagrophytes, and the activity might lead to irreversible cellular disruption .
|
-
- HY-147644
-
|
|
α-synuclein
|
Neurological Disease
|
|
α-Synuclein inhibitor 3 (Compound 7g) is a α-synuclein (α -Syn) aggregation inhibitor. α-Synuclein inhibitor 3 can be used for Parkinson’s disease research [1].
|
-
- HY-N1132
-
|
D-Trehalose; α,α-Trehalose
|
Endogenous Metabolite
|
Metabolic Disease
|
|
D-(+)-Trehalose (α,α-Trehalose) is an orally active disaccharide, showing anti-desiccant and cryopreservative activities. D-(+)-Trehalose acts as an osmolyte, and stress protectant and helps in the storage and transport of carbon. D-(+)-Trehalose can be used as a food ingredient and pharmaceutical excipient [1] .
|
-
- HY-134036
-
-
- HY-N2848
-
-
- HY-N7276
-
|
|
Others
|
Others
|
|
7α-Galloyloxysweroside is a natural product [1].
|
-
- HY-149509
-
|
|
α-synuclein
|
Neurological Disease
|
|
α-Synuclein inhibitor 9 (Compound 20C) is an α-Synuclein inhibitor. α-Synuclein inhibitor 9 binds to cavities in mature α-synuclein fibrils and reduces the β-sheet structure. α-Synuclein inhibitor 9 inhibits A53T α-Syn aggregation. α-Synuclein inhibitor 9 has neuroprotective effect, improves brain functional connection and relieves motor dysfunction.α-Synuclein inhibitor 9 can be used for Parkinson’s disease (PD) research. [1].
|
-
- HY-160532
-
|
|
Casein Kinase
|
Cancer
|
|
CK1α degrader-1 (Compound 82) is an orally active CK1α degrader with a DC50 of 0.105 μM. CK1α degrader-1 can be used for the research of cancer [1].
|
-
- HY-168465
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-83 (compound I-1) is a potent inhibitor of α-Glucosidase, with the IC50 of 1.49 μg/mL. α-Glucosidase-IN-83 shows reduction in blood glucose levels in vivo [1].
|
-
- HY-N12689
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-56 (compound 1) is an orally active, potent α‐glucosidase inhibitor with an IC50 value of 45.86 μM. α-Glucosidase-IN-56 has potent anti-glycation activities [1].
|
-
- HY-109564
-
|
|
Drug Metabolite
|
Cancer
|
|
5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite of progesterone, and it can be produced in starved androgen-responsive prostate cancer cells.
|
-
- HY-18509
-
|
|
IRE1
|
Cancer
|
|
IRE1α kinase-IN-2 is a potent IRE1α kinase inhibitor, with an EC50 of 0.82 μM. IRE1α kinase-IN-2 inhibits IRE1α kinase autophosphorylation (IC50=3.12 μM). IRE1α kinase-IN-2 inhibits XBP1 mRNA splicing in the WT cell lines [1].
|
-
- HY-B0098AR
-
-
- HY-105537
-
|
RS-100975
|
Adrenergic Receptor
|
Endocrinology
|
|
Ro 70-0004 (RS-100975) is a selective alpha1A-adrenoceptor antagonist with a pKi of 8.9. Ro 70‐0004 can be used in the study of prostatic hyperplasia [1].
|
-
- HY-101385
-
-
- HY-12760R
-
|
|
Adrenergic Receptor
|
Cardiovascular Disease
Endocrinology
|
|
Indoramin (Standard) is the analytical standard of Indoramin. This product is intended for research and analytical applications. Indoramin is an orally active antihypertensive agent. Indoramin is also selective for the α1A-adrenoceptor [1].
|
-
- HY-W739985
-
|
7α-Thiomethylspironolactone
|
SARS-CoV
Estrogen Receptor/ERR
|
Infection
|
|
7α-(Thiomethyl)spironolactone is a nuclear steroid receptor antagonist that can be used for the research of coronaviruses [1].
|
-
- HY-113091
-
|
|
Apoptosis
|
Neurological Disease
|
|
Alpha-Tocotrienol is a vitamin E analog with anti-apoptotic neuroprotective action and antioxidant properties. Alpha-Tocotrienol prevents oxidative stress-independent apoptotic cell death, DNA cleavage, and nuclear morphological changes [1].
|
-
- HY-121735
-
|
|
Biochemical Assay Reagents
|
Others
|
|
2α-Mannobiose is a disaccharide composed of two mannose molecules linked by a 1-2 glycosidic bond. 2α-Mannobiose can be used for affinity purification of mannose-binding proteins by column chromatography [1].
|
-
- HY-131450A
-
|
|
Drug Isomer
|
Others
|
|
(E)-1α,25-Dihydroxyprevitamin D3 is a structurally related analog of 1α,25(OH)2D3 [1].
|
-
- HY-17034A
-
|
(+)-Medetomidine hydrochloride; (S)-Medetomidine hydrochloride
|
Adrenergic Receptor
|
Neurological Disease
Endocrinology
Cancer
|
|
Dexmedetomidine hydrochloride ((+)-Medetomidine hydrochloride) is a potent, selective and orally active agonist of α2-adrenoceptor, with a Ki of 1.08 nM. Dexmedetomidine hydrochloride shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine hydrochloride exhibits anxiolysis, sedation, and modest analgesia effects [1] .
|
-
- HY-146144
-
|
|
HIF/HIF Prolyl-Hydroxylase
|
Cancer
|
|
HIF-IN-1 (Compound 3c) is a hypoxia-inducible factor (HIF)-1 inhibitor. HIF-IN-1 suppresses HIF-1α protein accumulation without affecting the levels of HIF-1α mRNA. HIF-IN-1 shows no obvious cytotoxicity [1].
|
-
- HY-101061
-
|
|
Adrenergic Receptor
|
Cardiovascular Disease
|
|
2-MPMDQ is a potent and selective α1-adrenoceptor (Ki=0.37 nM) antagonist over α2-adrenoceptor (Ki=1740 nM). 2-MPMDQ is potent anti-hypertensive agent and has the potential for hypertension research [1].
|
-
- HY-12719
-
|
(+)-Medetomidine; (S)-Medetomidine
|
Adrenergic Receptor
|
Neurological Disease
Cancer
|
|
Dexmedetomidine ((+)-Medetomidine) is a potent, selective and orally active agonist of α2-adrenoceptor, with a Ki of 1.08 nM. Dexmedetomidine shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine exhibits anxiolysis, sedation, and modest analgesia effects [1] .
|
-
- HY-E70063
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
alpha-2,3-Sialyltransferase (Phα2,3SiaT) is a beta-galactoside. alpha-2,3-Sialyltransferase (Phα2,3SiaT) catalyzes the transfer of sialic acid to carbohydrate groups of glycoproteins and glycolipids [1].
|
-
- HY-19496
-
|
Buagafuran; Buagarofuran
|
5-HT Receptor
|
Neurological Disease
|
|
4-Butyl-alpha-agarofuran (AF 5) is an anxiolytic and antidepressant agent. 4-Butyl-alpha-agarofuran a α-agarofuran derivative that can be isolated from Gharu-wood. 4-Butyl-alpha-agarofuran can be used for the research of neurological disease research [1].
|
-
- HY-N9262
-
|
|
Others
|
Others
|
|
2α,7β,13α-Triacetoxy-5α-cinnamoyloxy-9β-hydroxy-2(3→20)abeotaxa-4(20),11-dien-10-one is a Diterpenoids product that can be isolated from the herbs of Taxus yunnanensis [1].
|
-
- HY-131723
-
|
|
Cytochrome P450
|
Metabolic Disease
|
|
Pregnenolone 16α-carbonitrile is an orally active prototypical and effective rodent-PXR activator. Pregnenolone 16α-carbonitrile, a synthetic steroid, induces cytochrome P450 3A expression. Pregnenolone 16α-carbonitrile exhibits increased resistance to subsequent stressful insults [1] .
|
-
- HY-146156
-
-
- HY-150960
-
-
- HY-19610
-
|
α-Amatoxin
|
DNA/RNA Synthesis
ADC Cytotoxin
|
Cancer
|
|
α-Amanitin is the principal toxin of several deadly poisonous mushrooms, exerting its toxic function by inhibiting RNA-polymerase II.
|
-
- HY-170588
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-78 (Compound 12m) is an inhibitor for α-glucosidase with a reversible, competitive IC50 6.0 μM. α-Glucosidase-IN-78 can be used in research of diabete for its hypoglycemic property [1].
|
-
- HY-162697
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-69 (compound 5k) is a competitive α-glucosidase inhibitor with an IC50 of 26.8 µM and a Ki value of 26.0 µM. α-Glucosidase-IN-69 has the potential for the diabetes research [1].
|
-
- HY-155344
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-38 (Compound 11j) is a potent inhibitor of α-glucosidase inhibitor with IC50 of 12.44±0.38 μM.α-Glucosidase-IN-38 plays an important role in Diabetes mellitus (DM) [1].
|
-
- HY-162541
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-64 (compound 10) is a potent α-glucosidase inhibitor with an IC50 value of 8.62 µM. α-Glucosidase-IN-64 is a polycyclic polyprenylated acylphloroglucinol that can be isolated from hypericum beanii [1].
|
-
- HY-170702
-
-
- HY-169406
-
|
|
Glycosidase
|
Cancer
|
|
α-Glucosidase-IN-76 (Compound 4r) is an inhibitor for α-glucosidase with an IC50 of 5.44 μM. α-Glucosidase-IN-76 scavenges ABTS+ free radicals with a TEAC value of 0.49. α-Glucosidase-IN-76 inhibits the proliferation of T24 bladder cancer cell with IC50 of 1.74 μM [1].
|
-
- HY-169330
-
|
|
Drug Metabolite
|
Neurological Disease
Metabolic Disease
|
|
3β,5α,6β-Trihydroxycholanic acid is a metabolite of 3β,5α,6β-Trihydroxycholestane (HY-W010934). 3β,5α,6β-Trihydroxycholanic acid can be used in research related to neurodegenerative diseases associated with lysosomal dysfunction [1].
|
-
- HY-128417AR
-
|
|
Biochemical Assay Reagents
Reference Standards
|
Others
|
|
alpha-D-glucose (hydrate) (Standard) is the analytical standard of alpha-D-glucose (hydrate). This product is intended for research and analytical applications. alpha-D-glucose hydrate is a monosaccharide and the most common form of glucose. It is a monosaccharide, which means it cannot be broken down into simpler sugars. alpha-D-glucose plays a vital role in energy metabolism and is the primary source of energy for many cells in the body. It is also a building block of larger carbohydrates such as starch and glycogen. The "α" prefix refers to the orientation of the hydroxyl group attached to the first carbon atom. Alpha-D-glucose exists in solution as a hydrate, which means it is bound to water molecules.
|
-
- HY-176014
-
|
17-Phenyl trinor PGF2α glycinamide
|
Drug Derivative
|
Others
|
|
17-phenyl trinor PGF2α glycinamide (17-Phenyl trinor PGF2α glycinamide) is a derivative of 17-phenyl trinor prostaglandin F2α ethyl amide [1].
|
-
- HY-104076A
-
-
- HY-W751152
-
|
|
GABA Receptor
|
Cancer
|
|
α,β-Thujone is a component of the essential oils of some plants. α,β-Thujone causes cancers in male rats and induces seizures in the highest doses [1].
|
-
- HY-N1614
-
|
|
Others
|
Others
|
|
1 α-hydroxytorilin (compound 3) is a sesquiterpenoid. 1 α-hydroxytorilin can be isolated from Torilis japonica. 1α-hydroxytorilin has cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells with ED50 values of 20.52, 18.24, 17.48, 42.54 μg/mL, respectively [1].
|
-
- HY-115822
-
|
|
Amino Acid Decarboxylase
Glutathione S-transferase
|
Metabolic Disease
|
|
α-Fluoromethylhistidine dihydrochloride is a potent irreversible inhibitor of histidine decarboxylase (HDC) and glutathione S-transferase, demonstrating significant potential in studying histidine metabolism and drug metabolism processes. α-Fluoromethylhistidine dihydrochloride offers an effective approach to inhibit enzymes involved in these metabolic pathways. α-Fluoromethylhistidine dihydrochloride has implications for drug development by revealing off-target effects that may influence physiological drug metabolism and elimination mechanisms.
|
-
- HY-159945
-
|
|
α-synuclein
|
Neurological Disease
|
|
Tau Protein/α-synuclein-IN-2 (Compound 14T) is a blood-brain barrier penetrating tau and α-syn inhibitor. Through its thiourea linker structure, Tau Protein/α-synuclein-IN-2 dose-dependently reduces α-syn oligomerization. In biosensor cells, Tau Protein/α-synuclein-IN-2 prevents the seeding effect of tau aggregation. In the M17D neuroblastoma model, Tau Protein/α-synuclein-IN-2 exhibits anti-inclusion effects. Additionally, Tau Protein/α-synuclein-IN-2 reduces Aβ plaque formation. Tau Protein/α-synuclein-IN-2 holds promise for Alzheimer's disease and Parkinson's disease research. [1]
|
-
- HY-106037
-
|
|
Prostaglandin Receptor
|
Others
|
|
PGF2α-isopropyl ester is a Prostaglandin F2α (HY-12956) derivative, which is active in lowering the intraocular pressure (IOP) through increased uveoscleral outflow of aqueous humor. PGF2α-isopropyl ester causes side effects of conjunctival hyperemia and ocular irritation [1].
|
-
- HY-129953C
-
|
5-trans PGF2α tromethamine
|
Drug Derivative
|
Cardiovascular Disease
|
|
5-trans Prostaglandin F2α tromethamine is a derivative of 5-trans Prostaglandin F2α (HY-129953A). 5-trans Prostaglandin F2α is an endogenous metabolite present in blood that can be used for the research of myocardial infarction [1].
|
-
- HY-W020182R
-
|
Terpilene (Standard)
|
Reference Standards
Fungal
Parasite
|
Infection
|
|
α-Terpinene (Standard) is the analytical standard of α-Terpinene. This product is intended for research and analytical applications. α-Terpinene (Terpilene) is a monoterpene found in the essential oils of a large variety of foods and aromatic plants such as Mentha piperita. α-Terpinene is active against Trypanosoma evansi and has the potential for trypanosomosis treatment. α-Terpinene has antioxidant and antifungal properties [1] .
|
-
- HY-N0375
-
-
- HY-130264
-
|
|
HIF/HIF Prolyl-Hydroxylase
|
Cancer
|
|
HIF-2α-IN-2 is a hypoxia-inducible factors (HIF-2α) inhibitor extracted from patent WO2015035223A1, Compound 232, has an IC50 of 16 nM in scintillation proximity assay (SPA) [1].
|
-
- HY-154998
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-27 (compound 8l) is an α-glucosidase inhibitor (IC50=25.78 μM). α-Glucosidase-IN-27 has the potential to study type 2 diabetes (D2M) [1].
|
-
- HY-N12347
-
|
|
Others
|
Inflammation/Immunology
|
|
α-Glucosidase-IN-37 (Compound 11) moderately inhibits LPS-induced NO production with an IC50 value of 23.7 μM in macrophages. α-Glucosidase-IN-37 has weak inhibitory activity against α-Glucosidase [1].
|
-
- HY-W330621
-
|
CNP-α-D-Glucopyaoside
|
Fluorescent Dye
|
Others
|
|
2-Chloro-4-nitrophenyl-α-D-glucopyranoside (CNP-α-D-Glucopyaoside) as a chromogenic substrate for the enzymatic activity assay of the enzyme that releases CNP from conjugated carbohydrates [1].
|
-
- HY-Y0191R
-
-
- HY-146787S
-
-
- HY-146784S
-
-
- HY-43470
-
-
- HY-150959
-
-
- HY-W715183
-
-
- HY-162395
-
-
- HY-150961
-
-
- HY-N9079
-
|
|
Others
|
Others
|
|
8alpha-(2-Methylacryloyloxy)hirsutinolide is a Sesquiterpenoids product that can be isolated from the herbs of Vernonia cinerea. [1].
|
-
- HY-162262
-
-
- HY-N1227
-
-
- HY-107462
-
-
- HY-157731
-
-
- HY-NP020
-
|
E.coli DH-5 Alpha protein
|
Bacterial
|
Others
|
|
E.coli DH-5 alpha Bacterial protein is a purified native protein from E.coli DH-5 alpha bacterial [1].
|
-
- HY-CE00046
-
-
- HY-149008
-
|
|
Amylases
Cholinesterase (ChE)
|
Inflammation/Immunology
|
|
α-Amylase-IN-3 (Compound 4) is the inhibitor for α-Amylase, AChE and AChE with IC50s of 18.04 μM, 21.04 μM and 22.2 μM, respectively. α-Amylase-IN-3 exhibits antioxidant activity. α-Amylase-IN-3 can be used in research of diabetes and oxidative stress associated disease [1] .
|
-
- HY-W250310
-
|
L-Arginine Alpha-ketoglutarate
|
Biochemical Assay Reagents
|
Others
|
|
L-Arginine α-ketoglutarate, often abbreviated as AAKG, is a dietary supplement that combines arginine L-Arginine and α-ketoglutarate, a key intermediate in the Krebs cycle. L-arginine is a precursor of nitric oxide, which regulates blood flow and promotes vasodilation, while α-ketoglutarate is involved in energy production and protein synthesis. Together, these compounds are thought to support improved muscle recovery, increased endurance, and enhanced athletic performance.
|
-
- HY-B2235C
-
|
|
Biochemical Assay Reagents
|
Metabolic Disease
|
|
L-α-Lecithin (soybean) is a kind of biological materials. L-α-Lecithin (soybean) can be used for studying cell membrane structure, biofilm potential, liposome research, etc [1].
|
-
- HY-W014941
-
|
|
Histamine Receptor
|
Neurological Disease
|
|
(R)-(-)-α-Methylhistamine dihydrochloride is a potent, selective and brain-penetrant agonist of H3 histamine receptor, with a Kd of 50.3 nM [1] . (R)-(-)-α-Methylhistamine dihydrochloride can enhance memory retention, attenuates memory impairment in rats .
|
-
- HY-136347R
-
-
- HY-137547
-
|
|
Prostaglandin Receptor
|
Metabolic Disease
|
|
20-hydroxy Prostaglandin F2α (20-hydroxy PGF2α) is the ω-oxidation product of PGF2α. Cultured type II alveolar cells from pregnant rabbits metabolize exogenous PGF2α via microsomal cytochrome P450 ω-oxidation, producing 20-hydroxy PGF2α and its 15-hydroxy PGDH metabolites. Cells from male rabbits exhibit only the 15-hydroxy PGDH pathway.
|
-
- HY-133830
-
|
(3β,7α,24S)-Cholest-5-ene-3,7,24-triol
|
Endogenous Metabolite
|
Others
|
|
7α,24(S)-Dihydroxycholesterol ((3β,7α,24S)-Cholest-5-ene-3,7,24-triol) serves as a ligand for liver X receptor (LXR), binding specifically to the ligand binding domains of both LXRα and LXRβ. This compound is synthetically produced from E-α,β-enone, utilizing Arsonium ylide and J-tert-butyldimethylsilyloxy-bisnor-5-cholenaldehyde as starting materials, followed by a series of transformations to yield 7α,24(S)-dihydroxycholesterol.
|
-
- HY-N8847S
-
-
- HY-128417A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
alpha-D-glucose hydrate is a monosaccharide and the most common form of glucose. It is a monosaccharide, which means it cannot be broken down into simpler sugars. alpha-D-glucose plays a vital role in energy metabolism and is the primary source of energy for many cells in the body. It is also a building block of larger carbohydrates such as starch and glycogen. The "α" prefix refers to the orientation of the hydroxyl group attached to the first carbon atom. Alpha-D-glucose exists in solution as a hydrate, which means it is bound to water molecules.
|
-
- HY-U00367
-
-
- HY-135525
-
-
- HY-14571
-
E7820
4 Publications Verification
ER68203-00
|
Molecular Glues
Integrin
|
Cancer
|
|
E7820 (ER68203-00), an orally active aromatic sulfonamide derivative, is a unique angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium. E7820 inhibits rat aorta angiogenesis with an IC50 of 0.11 μg/ml. E7820 modulates α-1, α-2, α-3, and α-5 integrin mRNA expression. Antiangiogenic and antitumor activity [1] .
|
-
- HY-166295
-
-
- HY-139367
-
-
- HY-W753325
-
-
- HY-150718S
-
-
- HY-W017406S
-
-
- HY-W010249S
-
-
- HY-W553514
-
|
|
Biochemical Assay Reagents
|
|
|
DL-α-Phosphatidylcholine, distearoyl is a synthetic form of phosphatidylcholine that has the activity of spontaneously forming bilayer membranes in aqueous environments. DL-α-Phosphatidylcholine, distearoyl is an important component of biological membranes and provides support for the integrity of cell structures. DL-α-Phosphatidylcholine, distearoyl plays a key role in the preparation of compound delivery systems to improve the solubility and biocompatibility of compounds.
|
-
- HY-129459R
-
|
|
Reference Standards
Endogenous Metabolite
|
Cardiovascular Disease
Neurological Disease
|
|
α-Tocotrienol (Standard) is the analytical standard of α-Tocotrienol. This product is intended for research and analytical applications. α-Tocotrienol is an isoform of vitamin E and found in vegetables, fruits, seeds, nuts, grains, and oils. Vitamin E plays a role as an antioxidant, in lowering cholesterol and other lipids, as a neuroprotective and anticancer agent, and in cardiovascular disease protection.
|
-
- HY-N3411
-
|
13E-Labdene-8α,15-diol; Copal-8α,15-diol
|
Others
|
Others
|
|
Labd-13(E)-ene-8α,15-diol is a diterpene with the labdane skeleton which can be extracted from Cistus symphytijbfolius [1].
|
-
- HY-101332
-
EGLU
1 Publications Verification
(2S)-α-Ethylglutamic acid; (2S)-α-EGLU
|
mGluR
|
Neurological Disease
|
|
EGLU ((2S)-α-Ethylglutamic acid; (2S)-α-EGLU) is a potent and competitive mGluR-2 receptor antagonist. EGLU interacts with (lS,3S)-ACPD-sensitive site with a Kd value of 66 μM. EGLU is an antidepressant agent [1].
|
-
- HY-138213
-
|
|
Others
|
Others
|
|
Afzelechin-(4α→8)-epiafzelechin is a Flavonoids product that can be isolated from the herbs of Cassia javanica [1].
|
-
- HY-156447
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-40 (compound 5) is a noncompetitive α-glucosidase enzyme inhibitor with an IC50 of 24.62 μM [1].
|
-
- HY-N10935
-
|
|
Others
|
Others
|
|
2-Desoxyflorilenalin-L-α-arabinopyranoside is an active compound. 2-Desoxyflorilenalin-L-α-arabinopyranoside can be isolated from Helenium amarum [1].
|
-
- HY-147879
-
-
- HY-B2193A
-
|
1,4-Alpha-D-Glucan-glucanohydrolase, ptyalin
|
Biochemical Assay Reagents
|
Others
|
|
α-Amylase, Human Saliva (1,4-alpha-D-Glucan-glucanohydrolase, ptyalin) is a biological material or organic compound that can be used in life science research [1] .
|
-
- HY-148860
-
|
HIF-2α-IN-8
|
HIF/HIF Prolyl-Hydroxylase
|
Cancer
|
|
HIF-2α-IN-8 is a potent and orally active HIF2α inhibitor with IC50 values of 9, 37, 246 nM for HIF2α SPA, HIF2α iScript, HIF2α HRE RGA, respectively. HIF-2α-IN-8 shows antitumor activity [1].
|
-
- HY-151138
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-16 is a potent and orally active α-glucosidase inhibitor with an IC50 value of 3.28 μM. α-Glucosidase-IN-16 can reduce the level of blood glucose in Streptozotocin-induced diabetic rats. Antidiabetic activity [1].
|
-
- HY-149342
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-29 (compound 19) is a α-glucosidases inhibitor (IC50=1.21 μM, Ki=1.80 μM). α-Glucosidase-IN-29 ca be used for research of diabetes and related diseases [1].
|
-
- HY-173183
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-87 (Compound 11c) is an orally active α-glucosidase inhibitor with an IC50 value of 119.7 μM. α-Glucosidase-IN-87 has hypoglycemic activity and can be used in the research of metabolic diseases such as diabetes [1].
|
-
- HY-163907
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-71 (Compound 7h) is a competitive α-glucosidase inhibitor (IC50: 98.0 µM). α-Glucosidase-IN-71 can be used for research of carbohydrate-related diseases, especially type 2 diabetes mellitus [1].
|
-
- HY-149332
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-26 (Compound 7i) is an α-glucosidase inhibitor (IC50=4.63 µM). α-Glucosidase-IN-26 can be used in the study of type 2 diabetes mellitus (T2DM) [1].
|
-
- HY-172138
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-84 (Compound 7j) is a competitive α-glucosidase inhibitor with an IC50 of 50 μM and a Ki of 32 μM. α-Glucosidase-IN-84 holds potential for use in the field of metabolic diseases, such as the study of type 2 diabetes [1].
|
-
- HY-161281
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-49 (compound C23) is a potent inhibitor of α-Glucosidase, with IC50 of 0.52 μM. α-Glucosidase-IN-49 has oral bioactivity that can reduce blood glucose and improve glucose tolerance in mice [1].
|
-
- HY-149409
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-31 (compound R1) is an orally active, potent α-Glucosidase inhibitor with an IC50 value of 10.1 μM. α-Glucosidase-IN-31 significantly reduces the blood glucose level and has antidiabetic activity [1].
|
-
- HY-158196
-
|
|
PERK
Apoptosis
|
Cancer
|
|
PERK/eIF2α activator 1 (compound V8) is a flavonoid with an anti-tumor activity. PERK/eIF2α activator 1 induces apoptosis and activates the PERK-eIF2α-ATF4 pathway. PERK/eIF2α activator 1 inhibits HepG2 cell proliferation with an IC50 value of 23 μM [1].
|
-
- HY-N0728S
-
|
|
Isotope-Labeled Compounds
PI3K
Akt
|
Cardiovascular Disease
Cancer
|
|
α-Linolenic acid-d5 is the deuterium labeled α-Linolenic acid. α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer [1].
|
-
- HY-N0728S2
-
|
|
Isotope-Labeled Compounds
PI3K
Akt
|
Cardiovascular Disease
Cancer
|
|
α-Linolenic acid-d14 is the deuterium labeled α-Linolenic acid. α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer [1].
|
-
- HY-162620
-
|
|
Adrenergic Receptor
|
Cancer
|
|
α2A-AR agonist 1 (Compound B9) is a selective agonist for α2-adrenergic receptor (α2A-AR) with EC50 of 0.23 nM. α2A-AR agonist 1 exhibits a hypnotic effect, with ED50 of 0.138 mg/kg in the loss of righting reflex (LORR) experiment. α2A-AR agonist 1 exhibits metabolic stability in mouse liver microsomes [1].
|
-
- HY-172001
-
|
|
Drug Derivative
|
Cancer
|
|
α-GalCer analog 8 is a triazole derivative of α-Galactosylceramide (HY-102022). α-Galactosylceramide is a synthetic glycolipid with antitumorial and immunostimulatory [1].
|
-
- HY-146638S
-
|
|
Isotope-Labeled Compounds
|
Cancer
|
|
5α-Pregnan-11β,17α,21-triol-3,20-dione-1,2,4,5-d4 is the deuterium labeled 5α-Pregnan-11β,17α,21-triol-3,20-dione-1,2,4,5 [1].
|
-
- HY-169347
-
|
LC-05-004
|
Molecular Glues
Casein Kinase
|
Cancer
|
|
dCK1α-2 is an orally active CK1α molecular glue degrader that targets p53 pathway-related targets. dCK1α-2 exhibits anti-tumor efficacy in mouse models and can increase the expression of p53-related genes. [1].
|
-
- HY-157308
-
|
|
α-synuclein
|
Neurological Disease
|
|
α-Synuclein inhibitor 10 (compound a8) inhibits the activity of α-Syn aggregation with low IC50 value (1.08 μM). α-Synuclein inhibitor 10 exhibits good binding affinity to α-Syn residues. α-Synuclein inhibitor 10 can be used in the research of Parkinson's disease (PD) [1].
|
-
- HY-P990855
-
|
|
Integrin
|
Others
|
|
Anti-CD8α Antibody (OKT-8) is a kind of mouse IgG2a chimeric antibody, targeting to human CD8α. The recommend isotype control of Anti-CD8α Antibody (OKT-8): Mouse IgG2a kappa, Isotype Control (HY-P99978).
|
-
- HY-U00110
-
-
- HY-P3612
-
|
|
CXCR
|
Inflammation/Immunology
|
|
CTCE-0214 is a chemokine CXC receptor 4 (CXCR4) agonist, SDF-1α (stromal cell-derived factor-1α) peptide analog. CTCE-0214 shows anti-inflammatory activity, and can be used in inflammation sepsis and systemic inflammatory syndromes research [1] .
|
-
- HY-Y0585R
-
|
|
Reference Standards
Bacterial
|
Infection
Inflammation/Immunology
|
|
D-(-)-Mandelic acid (Standard) is the analytical standard of D-(-)-Mandelic acid. This product is intended for research and analytical applications. D-(-)-Mandelic acid is an orally active alpha hydroxycarboxylic acid that can be isolated from bitter almonds and Indian chestnut trees. It has antioxidant and antibacterial properties and is expected to play an important role in the treatment of rheumatoid arthritis [1] .
|
-
- HY-157922
-
|
α-D-Glucopyranosyl-α-D-glucopyranoside monododecanoate
|
Biochemical Assay Reagents
|
Others
|
|
Trehalose C12 (α-D-Glucopyranosyl-α-D-glucopyranoside monododecanoate) is a nonreducing disaccharide with amphiphilic property, which is used as emulsifier, surfactant, encapsulating materials, and in the biochemical researches of cellular processes and membrane interactions [1].
|
-
- HY-N1917
-
-
- HY-N10320
-
-
- HY-129389
-
|
|
Glycosyltransferase
|
Cancer
|
|
Benzyl-α-GalNAc is a potent O-glycosylation inhibitor. Benzyl-α-GalNAc effectively inhibits the proliferation and activation of LX-2 cells and suppresses the expression of collagen I/III, which has good potential for investigation in liver fibrosis. Benzyl-α-GalNAc also significantly enhances the anti-tumour activity of 5-FU (HY-90006) (e.g. pancreatic cancer) by inhibiting O-glycosylation [1] .
|
-
- HY-144561S
-
-
- HY-128417R
-
|
|
Reference Standards
Endogenous Metabolite
|
Metabolic Disease
|
|
alpha-D-glucose (Standard) is the analytical standard of alpha-D-glucose. This product is intended for research and analytical applications. \alpha-D-glucose is a monosaccharide that has a more significant insulin stimulating effect than beta-D-glucose[1][2].
|
-
- HY-161421
-
|
|
Glycosidase
|
Metabolic Disease
|
α-Glucosidase-IN-61 (Compd 1j), a competitive α-glucosidase inhibitor, demonstrates excellent inhibition with an IC50 of 0.73 μM. α-Glucosidase-IN-61 (Compd 1j) is used for the research of type 2 diabetes mellitus [1].
|
-
- HY-168462
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-82 (compound 8l) is a potent inhibitor of α-Glucosidase, with the IC50 of 13.66 μM. α-Glucosidase-IN-82 exhibits a 52-fold increase in inhibitory activity relative to Acarbose (HY-B0089) [1].
|
-
- HY-N13173
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-70 (compound 9) is an α-glucosidase inhibitor (IC50=31.1 μM) isolated from the traditional Chinese herbal medicine Swertia mussotii. α-Glucosidase-IN-70 can be used in the research of diabetes [1].
|
-
- HY-131450
-
-
- HY-144241S
-
-
- HY-172758
-
|
|
Glycosidase
|
Others
|
α-Glucosidase-IN-89 (8g) is α-glucosidase inhibitor, with an IC50 of 0.5 μM and a Ki of 0.46 µM [1].
|
-
- HY-18510
-
|
|
IRE1
|
Others
|
|
IRE1α kinase-IN-7 (compound 4) is an IRE1α kinase inhibitor. IRE1α kinase-IN-7 can be used for research of endoplasmic reticulum stress-related diseases [1].
|
-
- HY-129348
-
|
|
IRE1
|
Cancer
|
|
IRE1α kinase-IN-10 (GP29) is an IRE1α kinase inhibitor. IRE1α kinase-IN-10 can be used for the research of endoplasmic reticulum stress-related diseases [1].
|
-
- HY-W353470
-
|
2,3-Dinor-8-isoPGF2α
|
Drug Metabolite
|
Metabolic Disease
|
|
2,3-Dinor-8-iso prostaglandin F₂α (2,3-Dinor-8-isoPGF2α) is the major β-oxidation metabolite of 8-iso-prostaglandin F₂α. 2,3-Dinor-8-iso prostaglandin F₂α serves as a biomarker to evaluate the in vivo production of 8-iso-prostaglandin F₂α and the level of lipid peroxidation. 2,3-Dinor-8-iso prostaglandin F₂α is promising for research of oxidative stress-related diseases such as arteriosclerosis and diabetes [1] .
|
-
- HY-P1545A
-
-
- HY-122144
-
|
Teroxirone
|
Endogenous Metabolite
|
Cancer
|
|
α-Triglycidyl isocyanurate (Teroxirone) is an antitumor compound with activity to inhibit DNA replication. α-Triglycidyl isocyanurate exerts its anticancer effect by alkylating and cross-linking DNA. α-Triglycidyl isocyanurate is relatively stable in fresh human plasma and whole blood, showing good biocompatibility. The metabolism of α-Triglycidyl isocyanurate mainly occurs in rat liver and is metabolized through an NADPH-independent pathway. The cytotoxicity of α-Triglycidyl isocyanurate can be partially restored under specific conditions, suggesting the complexity of its metabolic pathway [1].
|
-
- HY-147954
-
|
|
Carbonic Anhydrase
Cholinesterase (ChE)
|
Neurological Disease
Metabolic Disease
|
|
α-Glycosidase-IN-1 (compound MZ7) is a potent α-GLY (α-Glycosidase) inhibitor, with an IC50 of 44.72 nM and a KI of 41.74 nM. α-Glycosidase-IN-1 also shows inhibition profile against human carbonic anhydrase isoenzymes I and II (hCA I and hCA II), and acetylcholinesterase (AChE), with IC50 values of 104.87, 100.04, and 654.87 nM, respectively. α-Glycosidase-IN-1 can be used for the research of many diseases such as diabetes, Alzheimer’s disease, heart failure, ulcer, and epilepsy [1].
|
-
- HY-N4209
-
|
|
Others
|
Cardiovascular Disease
|
|
3α-Dihydrocadambine is a natural product isolated from the heartwoods of Anthocephalus cadamba.3α-Dihydrocadambine exhibits dose-dependent hypotensive and anti-hypertensive effects in anesthetized normotensive rats and in conscious spontaneously hypertensive rats [1] .
|
-
- HY-114761
-
|
|
Prostaglandin Receptor
|
Cardiovascular Disease
|
|
Prostaglandin F2α dimethyl amine is a Prostaglandin F2α (HY-12956) derivative. Prostaglandin F2α dimethyl amine is an antagonist for Prostaglandin F receptor (FP) [1]. Prostaglandin F2α dimethyl amine blocks the cardiovascular responses induced by orexin and Arachidonic acid (HY-109590) .
|
-
- HY-N0642
-
|
|
Others
|
Infection
Metabolic Disease
Cancer
|
|
α-L-Rhamnose monohydrate is a component of the plant cell wall pectic polysaccharides rhamnogalacturonan I and rhamnogalacturonan II. α-L-Rhamnose monohydrate is also a component of bacterial polysaccharides where it plays an important role in pathogenicity.
|
-
- HY-157806
-
|
|
α-synuclein
|
Neurological Disease
|
|
α-Synuclein inhibitor 12 (compound 4ce) is an inhibitor of α-Syn (α-synuclein) aggregation and can be used in the study of neurological diseases [1].
|
-
- HY-173337
-
|
|
HSP
Interleukin Related
|
Cancer
|
|
HSP90α-IN-1 is a HSP90α inhibitor (IC50 = 111 nM) that exhibits senolytic activity across various cellular senescence models. HSP90α-IN-1 is related to the xanthinic family. HSP90α-IN-1 is involved in research on combating age-related inflammaging and diseases, including cancer, and possibly extend a healthy lifespan [1].
|
-
- HY-117071A
-
|
Ro 115-1240 hydrochloride
|
Adrenergic Receptor
Apoptosis
|
Cardiovascular Disease
Endocrinology
|
|
Dabuzalgron (Ro 115-1240) hydrochloride is an orally active and selective α-1A adrenergic receptor agonist for the treatment of urinary incontinence. Dabuzalgron hydrochloride protects against Doxorubicin-induced cardiotoxicity by preserving mitochondrial function [1].
|
-
- HY-111984A
-
|
|
Adrenergic Receptor
|
Cardiovascular Disease
|
|
Quinazosin dihydrochloride is an antihypertensive α1-adrenergic receptor antagonist whose activity is associated with inhibition of granulopoiesis, resulting in neutropenia and leukopenia. Quinazosin dihydrochloride exhibits dose-related myelosuppression that is correlated with the duration of suppression [1].
|
-
- HY-101366
-
|
|
Adrenergic Receptor
|
Cardiovascular Disease
|
|
A-61603 is a selective α1A-adrenergic receptor agonist [1]. A-61603 increases the frequency of spontaneous Ca 2+ transients in rat ventricular myocytes in vitro .
|
-
- HY-N6969
-
|
|
Adrenergic Receptor
|
Endocrinology
|
|
Dicentrine is a natural product isolated from the plant Stephania epigaea Lo with antihypertensive effect. Dicentrine is an α1-adrenoceptor antagonist which has effective against human hyperplastic prostates [1].
|
-
- HY-117071
-
|
Ro 115-1240
|
Adrenergic Receptor
Apoptosis
|
Cardiovascular Disease
Endocrinology
|
|
Dabuzalgron (Ro 115-1240) is an orally active and selective α-1A adrenergic receptor agonist for the treatment of urinary incontinence. Dabuzalgron protects against Doxorubicin-induced cardiotoxicity by preserving mitochondrial function [1].
|
-
- HY-N0492S
-
-
- HY-170797
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-80 (Compound 10n) is a potent competitive inhibitor of α-glucosidase, with an IC50 of 48.4 μM. α-Glucosidase-IN-80 has good pharmacokinetic properties and toxicity profiles and can be used in the research of diabetes-related diseases [1].
|
-
- HY-163975
-
|
|
Glycosidase
|
Cancer
|
|
α-Glucosidase-IN-72 (compound 5i) is a 2,4-dichloro-N-phenylacetamide derivative and an α-glucosidase inhibitor (IC50: 6 μM). α-Glucosidase-IN-72 does not follow Lipinski's "rule of five" and does not induce cancer [1].
|
-
- HY-169117
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-74 (Compound 7d), an isatin-thiazole derivative, is a α-glucosidase inhibitor. α-Glucosidase-IN-74 exhibits antidiabetic activity by decreasing glycaemia and triglyceride levels in Streptozotocin (HY-13753)-induced diabetic animals [1].
|
-
- HY-139377
-
-
- HY-168807
-
-
- HY-137217
-
-
- HY-170051
-
-
- HY-168825
-
-
- HY-W741575
-
-
- HY-E70150
-
|
EC:2.4.3.3; Alpha-N-Acetylgalactosaminide Alpha-2,6-sialyltransferase 1
|
Sialyltransferase
|
Cancer
|
|
ST6 Sialyltransferase 1 (EC:2.4.3.3, ST6GALNAC1, SIAT7A, Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1)? transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. ST6 Sialyltransferase 1 plays an important role in cancer [1].
|
-
- HY-E70019
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
alpha-2-3,6-sialidase (BiNanH2) is a sialyltransferase, is often used in biochemical studies. alpha-2-3,6-sialidase (BiNanH2) catalyzes α-2,3/2,6-sialyltransfer from CMP-Neu5Ac to galactoside acceptors [1].
|
-
- HY-139119
-
|
|
Prostaglandin Receptor
|
Others
|
|
Prostaglandin F2α dimethyl amide is an antagonist for Prostaglandin F2α (HY-12956), which blocks 50% contraction on gerbilMeriones unguiculatus colon induced by PGF2α at 3.2 μg/mL [1].
|
-
- HY-N11908
-
|
cis-α-Santalol
|
Akt
Survivin
|
Cancer
|
|
α-Santalol is a naturally occurring sesquiterpene that is derived from sandalwood oil that inhibits cancer cell growth by inducing apoptosis, targeting the Akt/Survivin pathway.
|
-
- HY-121222
-
|
|
PI3K
Apoptosis
|
Cancer
|
|
alpha-Bisabolol, an orally active sesquiterpene alcohol, induces cell cycle arrest, mitochondrial apoptosis and inhibition of PI3K/Akt signalling pathways. alpha-Bisabolol exerts a protective action against Cisplatin (HY-17394)-induced nephrotoxicity by mitigating inflammation and oxidative stress through the inhibition of NFκB activation. alpha-Bisabolol exhibits anti-inflammatory, analgesic, antibiotic and anticancer activities [1] .
|
-
- HY-148301
-
-
- HY-N9187
-
|
|
Others
|
Others
|
|
1α,4β,10β-Trihydroxyguaia-2,11(13)-dien-12,6α-olide is a Sesquiterpenoids product that can be isolated from the rhizomes of Alisma orientale [1].
|
-
- HY-N8653
-
-
- HY-N6825
-
-
- HY-142659
-
|
|
IRE1
|
Cancer
|
|
IRE1α kinase-IN-6 is a potent IRE1α inhibitor with an IC50 value of 4.4 nM.
|
-
- HY-154759S
-
-
- HY-W740664
-
-
- HY-W740771
-
-
- HY-N15425
-
-
- HY-156250S
-
-
- HY-154758S
-
-
- HY-152552
-
|
|
α-synuclein
|
Neurological Disease
|
|
α-Synuclein inhibitor 8 is an active inhibitor of α-Synuclein with an IC50 value of 2.5 µM. α-Synuclein inhibitor 8 has highly inhibition on the aggregation and disaggregation of α-Synuclein fibers. α-Synuclein inhibitor 8 reduces the formation of inclusions in neurons that can repairs damage neurons and improves Parkinson’s disease (PD)-like symptoms. α-Synuclein inhibitor 8 has high antioxidant activity and low cytotoxicity [1].
|
-
- HY-163005
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-43 (compound AS14) is an α-glucosidase inhibitor (IC50: 4.32 μM) with acute hypoglycemic activity. α-Glucosidase-IN-43 exhibits safety and in vivo efficacy, is nontoxic to normal mouse fibroblasts, and is able to rescue streptozotocin (HY-13753)-induced diabetic rats. α-Glucosidase-IN-43 can be used to study postprandial hyperglycemia in diabetic patients [1].
|
-
- HY-20834
-
-
- HY-115433
-
-
- HY-W560402
-
|
|
Others
|
Others
|
|
α-Irone is a compound used as a fragrance ingredient that was evaluated toxicologically and dermatologically.
|
-
- HY-N2851
-
|
|
Others
|
Others
|
|
α-Spinasterone is a compound that can be isolated from Samanea saman [1].
|
-
- HY-12836
-
|
|
IFNAR
|
Inflammation/Immunology
|
|
IFN alpha-IFNAR-IN-1 is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR; inhibit MVA-induced IFN-α responses by BM-pDCs (IC50=2-8 uM).
|
-
- HY-170606
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-79 (Compound 4d9) is a non-competitive α-Glucosidase inhibitor with an IC50 of 2.11 μM, which is more potent than existing α-Glucosidase inhibitors such as Acarbose (HY-B0089) (IC50 of 327.0 μM) and HXH8r (IC50 of 15.32 μM). α-Glucosidase-IN-79 is non-cytotoxic to human normal hepatocyte (LO2) cells and shows good metabolic stability in rat plasma. α-Glucosidase-IN-79 holds promise for research into type 2 diabetes [1].
|
-
- HY-128417S4
-
-
- HY-152158
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-22 (compound 7i), a benzimidazole, is a potent α-glucosidase inhibitor with an IC50 of 0.64 μM. α-Glucosidase-IN-22 is a potent anti-diabetic agent and has the potential for type 2 diabetes mellitus (T2DM) research [1].
|
-
- HY-161462
-
|
|
ERK
p38 MAPK
|
Cancer
|
|
ERK2/p38α MAPK-IN-1 (Compound 1, In silico Hit-2) is a potent and selective ERK2 and p38α MAPK inhibitor, with an IC50 of 82 μM for ERK2. ERK2/p38α MAPK-IN-1 binds to the allosteric site of ERK2 and p38α MAPK in distinct manners. ERK2/p38α MAPK-IN-1 can be used for the research of type 2 diabetes [1].
|
-
- HY-113209R
-
|
|
Reference Standards
Endogenous Metabolite
|
Others
|
|
8-Isoprostaglandin F2α (Standard) is the analytical standard of 8-Isoprostaglandin F2α. This product is intended for research and analytical applications. 8-Isoprostaglandin F2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. 8-Isoprostaglandin F2α is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. 8-Isoprostaglandin F2α is a weak TP receptor agonist in vascular smooth muscle.
|
-
- HY-N10855
-
|
|
Others
|
Others
|
|
6α-Hydroxypolyporenic acid C, a lanostane triterpenoid, is a nature product that could be isolated from the sclerotium of Poria cocos. 6α-Hydroxypolyporenic acid C can be absorbed across intestinal epithelial cells [1].
|
-
- HY-170325
-
|
|
iGluR
|
Neurological Disease
|
|
17alpha-Hydroxywithanolide D is the allosteric modulator for NMDA receptor with an IC50 of 44.24 nM. 17alpha-Hydroxywithanolide D exhibits neuroprotective activity and can be used in research of Alzheimer's disease disease [1].
|
-
- HY-113344
-
|
16αOHE
|
Endogenous Metabolite
|
Metabolic Disease
|
|
16α-Hydroxyestrone (16αOHE) is a major Estradiol metabolite. 16α-Hydroxyestrone (16αOHE) can be used for the research of metabolic disease [1].
|
-
- HY-161411
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-60 (Compound 5k) exhibits a competitive inhibitory efficacy against α-Glucosidase, with IC50 of 10.8 μM [1].
|
-
- HY-154871
-
|
|
Endogenous Metabolite
|
Others
|
|
α-D-Glucosamine 1-phosphate is an E.coli metabolite. α-D-Glucosamine 1-phosphate is one of the precursors of peptidoglycan synthesis [1] .
|
-
- HY-12753AS
-
|
SR35021-d7 hydrochloride
|
Thyroid Hormone Receptor
Isotope-Labeled Compounds
|
Cardiovascular Disease
|
|
Debutyldronedarone-d7 hydrochloride is deuterated labeled Debutyldronedarone hydrochloride (HY-12753A). Debutyldronedarone (SR35021) hydrochloride, the main metabolite of Dronedarone, is a selective thyroid hormone receptor α1 (TRα1) inhibitor. Debutyldronedarone hydrochloride inhibits T3 binding to TRα1 and TRβ1 by 77% and 25%, respectively. Debutyldronedarone hydrochloride can be used for the research of arrhythmic [1].
|
-
- HY-12753AR
-
|
SR35021 hydrochloride (Standard)
|
Reference Standards
Thyroid Hormone Receptor
|
Cardiovascular Disease
|
|
Debutyldronedarone (hydrochloride) (Standard) is the analytical standard of Debutyldronedarone (hydrochloride). This product is intended for research and analytical applications. Debutyldronedarone (SR35021) hydrochloride, the main metabolite of Dronedarone, is a selective thyroid hormone receptor α1 (TRα1) inhibitor. Debutyldronedarone hydrochloride inhibits T3 binding to TRα1 and TRβ1 by 77% and 25%, respectively. Debutyldronedarone hydrochloride can be used for the research of arrhythmic [1].
|
-
- HY-B1278
-
-
- HY-13284S
-
-
- HY-12710
-
|
α-Yohimbine; Corynanthidine; Isoyohimbine
|
Adrenergic Receptor
|
Cancer
|
|
Rauwolscine is a selective α2-adrenoceptor antagonist that inhibits tumor growth and induces apoptosis [1].
|
-
- HY-142515S
-
-
- HY-B0141A
-
-
- HY-W357329
-
|
Acetobromo-Alpha-maltose,98%
|
Biochemical Assay Reagents
|
Others
|
|
Acetobromo-α-maltose,98% (Acetobromo-alpha-maltose,98%) is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology [1].
|
-
- HY-13249
-
|
1α-Hydroxy vitamin D4
|
VD/VDR
|
Cancer
|
|
1alpha-Hydroxy VD4, a 1alpha(OH)D derivative, can effectively induce the differentiation of monoblastic leukaemia U937, P39/TSU and P31/FUJ cells.
|
-
- HY-139804
-
-
- HY-N0242
-
|
|
PD-1/PD-L1
HIF/HIF Prolyl-Hydroxylase
STAT
|
Inflammation/Immunology
Cancer
|
|
Fraxinellone is isolated from the root bark of the Rutaceae plant, Dictamnus dasycarpus. Fraxinellone is a PD-L1 inhibitor and inhibits HIF-1α protein synthesis without affecting HIF-1α protein degradation. Fraxinellone has the potential to be a valuable candidate for cancer treatment by targeting PD-L1 [1].
|
-
- HY-156106
-
|
|
Ligands for E3 Ligase
HIF/HIF Prolyl-Hydroxylase
|
Cancer
|
|
VHL-IN-1 (compound 30) is a ubiquitin E3 ligase von Hippel-Lindau (VHL) inhibitor (dissociation constant Kd=37 nM) that stabilizes and induces HIF-1α transcriptional activity. VHL-IN-1 has potential as a HIF-1α stabilizer and degrader of proteolytically targeted chimeras (PROTACs) [1].
|
-
- HY-172757
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-88 (Compound 3K) is an orally active and potent α-glucosidase inhibitor with an IC50 value of 6.40 µM. α-Glucosidase-IN-88 inhibits carbohydrate hydrolysis by blocking the enzyme's ability to break down glycosidic bonds, thereby reducing postprandial blood glucose levels. α-Glucosidase-IN-88 is promising for research of type 2 diabetes mellitus (T2DM) [1].
|
-
- HY-171764
-
|
|
Fluorescent Dye
|
Others
|
|
β-Ethoxy-α-ketobutyraldehyde is a chemical probe. β-Ethoxy-α-ketobutyraldehyde specifically modifies the N1 and N2 positions of guanine. β-Ethoxy-α-ketobutyraldehyde is mainly used to study the steric protection of single-stranded/double-stranded regions of nucleic acids and protein binding sites. β-Ethoxy-α-ketobutyraldehyde can be used for nucleic acid structure analysis and footprint studies of protein-nucleic acid complexes [1].
|
-
- HY-162639
-
|
|
Glycosidase
Cholinesterase (ChE)
|
Neurological Disease
Metabolic Disease
|
|
α-Glucosidase-IN-68 (Compound 2) is an inhibitor for α-Glucosidase, AChE, and BChE, with IC50 of 0.251, 0.774 and 0.793 μM, respectively. α-Glucosidase-IN-68 exhibits antioxidant efficacy, with IC50 of 0.69 μM and 0.02 μM, in DPPH and ABTS experiments. α-Glucosidase-IN-68 exhibits antidiabetic effect in Streptozotocin (HY-13753)-induced diabetic rat models [1].
|
-
- HY-N8011
-
|
|
Others
|
Others
|
|
25(R)-3β,17α-Dihydroxy-5α-spirostan-6-one 3-O-α-D-rhamnopyranosyl-(1→2)-β-D-glucopyranoside is a compound that can be isolated from Lilium brownii var. viridulum [1].
|
-
- HY-W392246
-
-
- HY-N13349
-
|
|
Others
|
Others
|
|
5α-Hydroxychloranthalactone A is a natural product [1].
|
-
- HY-131654
-
-
- HY-N11659
-
-
- HY-158595
-
|
15(R),19(R)-Hydroxy PGF2α
|
Drug Derivative
|
Others
|
|
15(R),19(R)-Hydroxy prostaglandin F2α (15(R),19(R)-Hydroxy PGF2α) is an analog of 19(R)-Hydroxy-prostaglandin F2α. 19(R)-Hydroxy-prostaglandin F2α (HY-N7857) is an ω-1 hydroxylase metabolite of PGF2α found in human semen [1].
|
-
- HY-W127530R
-
|
Alpha-Tocopherol phosphate disodium (Standard); TocP disodium (Standard); Vitamin E phosphate disodium (Standard)
|
Reference Standards
Apoptosis
Reactive Oxygen Species (ROS)
|
Cardiovascular Disease
Cancer
|
|
α-Tocopherol phosphate (Standard) (alpha-Tocopherol phosphate (Standard)) disodium is the analytical standard of α-Tocopherol phosphate disodium (HY-W127530). This product is intended for research and analytical applications.
α-Tocopherol phosphate disodium is an antioxidant that protects against long-wave UVA1 induced cell death and scavenge UVA1 induced ROS in a skin cell model. α-Tocopherol phosphate disodium exhibits angiogenesis-promoting activity [1] .
|
-
- HY-106874A
-
|
RS-15385-197 hydrochloride
|
Adrenergic Receptor
|
Neurological Disease
|
|
Delequamine (RS-15385-197) hydrochloride is an orally active and selective α2-adrenergic receptor antagonist with a pKi of 9.5 for α2-adrenoceptors in rat cortex. Delequamine hydrochloride shows >1000 fold selectivity against 5-HT1A receptors and α1-adrenoceptors. Delequamine hydrochloride can be used for the study of erectile dysfunction [1].
|
-
- HY-106874
-
|
RS-15385-197
|
Adrenergic Receptor
|
Neurological Disease
|
|
Delequamine (RS-15385-197) is an orally active and selective α2-adrenergic receptor antagonist with a pKi of 9.5 for α2-adrenoceptors in rat cortex. Delequamine shows >1000 fold selectivity against 5-HT1A receptors and α1-adrenoceptors. Delequamine can be used for the study of erectile dysfunction [1].
|
-
- HY-N7136
-
|
|
Cytochrome P450
|
Metabolic Disease
|
|
α-Terpinyl acetate is a monoterpene ester isolated from Laurus nobilis L. essential oil. α-Terpinyl acetate is a competitive P450 2B6 substrate which binding to the active site of P450 2B6 with a Kd value of 5.4 μM [1] .
|
-
- HY-168759
-
|
|
Progesterone Receptor
Drug Derivative
|
Metabolic Disease
Cancer
|
|
11α-Hydroxytestosterone is a deriviative of Hydrocortisone (HY-N0583), with the relative binding affinity to progesterone receptor of 9% (comparing to R5020 (HY-119384) 100%). 11α-Hydroxytestosterone inhibits the growth and differentiation of human decidual cells in culture [1].
|
-
- HY-N1596
-
|
Ent-3-oxokaurane-16α,17-diol
|
Others
|
Others
|
|
Ent-16α,17-dihydroxykauran-3-one is a diterpenoid, which can be isolated from the roots of Euphorbia ebracteolata [1].
|
-
- HY-W280197
-
-
- HY-75095
-
|
S-(-)-α-Phenylethylamine; L-(-)-α-Methylbenzylamine
|
Drug Intermediate
Biochemical Assay Reagents
|
Neurological Disease
|
|
(S)-(-)-1-Phenylethanamine (S-(-)-α-Phenylethylamine; L-(-)-α-Methylbenzylamine) is a S-isomer of 1-Phenylethanamine (HY-W012848). 1-Phenylethanamine is a potential central nervous system stimulant and can be used to synthesize the tyrosine kinase inhibitor CLM3 (HY-164413) [1].
|
-
- HY-148252
-
|
|
Adrenergic Receptor
|
Endocrinology
|
|
ADRA1D receptor antagonist 1 (free base) (compound (R)-9s) is an orally active, potent and selective human α1D-adrenoceptor (α1D-AR) antagonist (Ki=1.6 nM). ADRA1D receptor antagonist 1 (free base) dose-dependently inhibits bladder contraction with an IC30 value of 15 nM. ADRA1D receptor antagonist 1 (free base) can be used in studies of overactive bladder disorders such as urinary urgency, frequency and incontinence.
|
-
- HY-100542
-
|
Disodium (R)-2-hydroxyglutarate
|
Reactive Oxygen Species (ROS)
ATP Synthase
mTOR
Endogenous Metabolite
|
Neurological Disease
Inflammation/Immunology
Cancer
|
|
D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling [1] .
|
-
- HY-P5043
-
|
|
α-synuclein
|
Neurological Disease
|
|
α-Synuclein (67-78) (human) is the 67-78 fragment of α-Synuclein. α-Synuclein (67-78) (human) promotes network activity drive and blocks KCl-induced syt1L-ab uptake [1].
|
-
- HY-170381
-
|
|
α-synuclein
|
Neurological Disease
|
|
α-syn aggregation inhibitor-1 (Compound 2e) is an inhibitor for α-syn aggregation. α-syn aggregation inhibitor-1 inhibits the cell viability of SH-SY5Y [1].
|
-
- HY-P10163
-
|
|
Fluorescent Dye
|
Others
|
|
α-Secretase Substrate II, Fluorogenic is an internally quenched fluorogenic peptide substrate for α-Secretase that contains the α-secretase cleavage site of β-Amyloid precursor protein (APP) [1].Ex/Em = 340/490 nm
|
-
- HY-W767047
-
|
|
Isotope-Labeled Compounds
Drug Intermediate
|
Others
|
|
α-Hydroxymethyl atropine-d5 is the deuterium labeled α-Hydroxymethyl atropine (HY-W587927). α-Hydroxymethyl atropine is the impurity, that could be produced in process of Atropine (HY-B1205) synthesis [1].
|
-
- HY-164358
-
-
- HY-N8164
-
-
- HY-W791671
-
|
|
Biochemical Assay Reagents
Apoptosis
|
Cancer
|
|
Aspergillus giganteus α-sarcin is a ribosome-inactivating protein that induces apoptosis in rhabdomyosarcoma cells. α-Sarcin is suitable for inducing apoptosis and inhibiting protein synthesis [1].
|
-
- HY-145542
-
-
- HY-149313
-
|
|
Amylases
|
Metabolic Disease
|
|
α Amylase-IN-1 (Compound 11) is an α-Amylase inhibitor with an IC50 value of 0.5509 μM. α Amylase-IN-1 has antioxidant activity with an IC50 value of 53.49 μM for scavenging DPPH free radicals. IC50 can be used in the study of diabetes and oxidative stress-related diseases. [1]
|
-
- HY-W145656
-
|
Alpha,beta-Trehalose
|
Biochemical Assay Reagents
|
Others
|
|
α,β-Trehalose is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-176221
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-92 (compound 14b) is a non-competitive inhibitor targeting α-glucosidase (IC50=64.0 μM), with better inhibitory potency than Acarbose (HY-B0089) (IC50=750 μM). α-Glucosidase-IN-92 has good oral bioavailability and can cross the blood-brain barrier. α-Glucosidase-IN-92 can delay carbohydrate hydrolysis and reduce postprandial blood glucose. α-Glucosidase-IN-92 can be used in anti-glycemic research for type 2 diabetes [1].
|
-
- HY-116679
-
|
17-Trifluoromethylphenyl trinor PGF2α
|
Prostaglandin Receptor
|
Endocrinology
|
|
A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for glaucoma. Of these, the unsubstituted or meta-substituted aromatic derivatives are the most potent FP receptor agonists.4 17-trifluoromethylphenyl trinor PGF2α bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl trinor PGF2α would act very much like the free acid of travoprost. 17-phenyl trinor PGF2α is a potent luteolytic, with a potency equal to or greater than fluprostenol and cloprostenol.
|
-
- HY-B1278AR
-
|
Vitamin E acetate (Standard)
|
Reference Standards
Endogenous Metabolite
|
Inflammation/Immunology
|
|
DL-α-Tocopherol acetate (Standard) is the analytical standard of DL-α-Tocopherol acetate. This product is intended for research and analytical applications. DL-α-Tocopherol acetate is a vitamin E derivative which is often included in the formulations of enteral nutrition.
|
-
- HY-E70558A
-
|
|
5 alpha Reductase
|
Endocrinology
|
|
5α-Reductase, Rat (Sprague-Dawley) Testis is the enzyme responsible for the conversion of testosterone into 5-alpha dihydrotestosterone (DHT), which is a potent androgen involved in male sexual differentiation.5α-reductase enzyme family is comprised of 3 subfamilies and 5 isoenzyme members: 5αR1, 5αR2, 5αR3, GPSN2, and GPSN2L [1].
|
-
- HY-E70558
-
|
|
5 alpha Reductase
|
Endocrinology
|
|
5α-reductase, Rat(Sprague-Dawley) Liver is the enzyme responsible for the conversion of testosterone into 5-alpha dihydrotestosterone (DHT), which is a potent androgen involved in male sexual differentiation.5α-reductase enzyme family is comprised of 3 subfamilies and 5 isoenzyme members: 5αR1, 5αR2, 5αR3, GPSN2, and GPSN2L [1].
|
-
- HY-W725213
-
|
BL-3912; Alpha-EH DOM
|
Biochemical Assay Reagents
|
Others
|
|
α-ethyl 2C-D (BL-3912) hydrochloride is a phenethylamine and amphetamine compound. In drug discrimination studies, α-ethyl 2C-D hydrochloride can serve as a reference standard for MDMA [1].
|
-
- HY-P9908
-
-
- HY-N10750
-
|
|
Others
|
Others
|
|
1α, 2α-Diacetoxy-8β-isobutanoyloxy-9α-benzoyloxy-15-β-(β-furancarbonyloxy)-4β, 6β-dihydroxy-β-dihydroagarofuran (compound 7) is an eudesmane-type sesquiterpenoid that can be founfd in the the root bark of Pseudolarix kaempferi [1].
|
-
- HY-169467
-
|
|
5-HT Receptor
Dopamine Receptor
|
Neurological Disease
|
|
5-Chloro-α-methyltryptamine (Compound 7b) is a potent and selective dual DA/5-HT releaser and 5-HT2a agonist. 5-Chloro-α-methyltryptamine releases DA and 5-HT with the EC50 values of 54.3 nM and 16.2 nM, respectively. 5-Chloro-α-methyltryptamine can be used in the study of neurotransmitter [1].
|
-
- HY-W008125
-
|
Acetobromo-Alpha-D-glucuronic acid methyl ester, 98%
|
Biochemical Assay Reagents
|
Others
|
|
Acetobromo-α-D-glucuronic acid methyl ester, 98% (Acetobromo-alpha-D-glucuronic acid methyl ester, 98%) can be used in glycobiology research and can undergo glycosylation reactions with suitable glycoside receptors.
|
-
- HY-N1156A
-
|
|
Others
|
Cardiovascular Disease
Cancer
|
|
α-Thevetin B（Compound 24） is a cardiac glycoside that can be isolated from Thevetia peruviana. α-Thevetin B（Compound 24） can be used in lung cancer, gastric cancer and pancreatic cancer research [1].
|
-
- HY-E70065
-
|
|
Sialyltransferase
|
Infection
|
|
alpha-2,3-Sialyltransferase (PmST2) is a sialyltransferase produced by Pasteurella multocida (Pm) and plays an important role in the pathogenesis of Pm. alpha-2,3-Sialyltransferase (PmST2) can be used to synthesize sialyllactosyl sphingosine (lyso-GM3) [1] .
|
-
- HY-120197
-
|
|
Prostaglandin Receptor
|
Endocrinology
|
|
17-Phenyl trinor prostaglandin F2α methyl amide is a prostaglandin F 2α (PGF 2α) analog that competes with native PGF 2α for receptor binding [1].
|
-
- HY-172586
-
|
|
GSK-3
PKA
|
Neurological Disease
Cancer
|
|
GSK-3α/β-IN-1 is GSK-3α/β inhibitor with IC50 s of 0.265 μM and 0.255 μM for GSK-3α and GSK-3β, respectively. GSK-3α/β-IN-1 also inhibits PKA with an IC50 of 0.188 μM. GSK-3α/β-IN-1 potently inhibits cell viability of three Glioblastoma (GBM) cell lines (IC50 : 3-6 μM, 72 h) with no toxicity to human astrocytes and good metabolic stability. GSK-3α/β-IN-1 has potential CNS activity in all-human blood-brain barrier (BBB) model of GBM [1].
|
-
- HY-168598
-
|
|
Amylases
|
Metabolic Disease
|
|
α-Amylase-IN-9 (Compound 1i) is an inhibitor of α-Amylase with an IC50 value of 14.64 μM, which can be used in diabetes research [1].
|
-
- HY-N0728S3
-
|
|
Isotope-Labeled Compounds
PI3K
Akt
|
Cardiovascular Disease
Cancer
|
|
α-Linolenic acid- 13C18 is the 13C labeled α-Linolenic acid. α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer [1].
|
-
- HY-163145
-
|
|
α-synuclein
|
Neurological Disease
|
|
α-Synuclein inhibitor 11 (compound 1) is a selective α-synuclein (α-syn) oligomer formation inhibitor. α-Synuclein inhibitor 11 does not inhibits tau 4R (isoforms 0N4R, 2N4R) or p-tau (isoform 1N4R). α-Synuclein inhibitor 11 can be used for Parkinson's disease (PD) research [1].
|
-
- HY-125833
-
|
|
Cytochrome P450
Aryl Hydrocarbon Receptor
Apoptosis
|
Cancer
|
|
Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis [1] .
|
-
- HY-116622
-
-
- HY-110203
-
|
TNF-α Antagonist III
|
TNF Receptor
|
Cancer
|
|
R-7050 (TNF-α Antagonist III) is a tumor necrosis factor receptor (TNFR) antagonist with greater selectivity toward TNFα.
|
-
- HY-P1781A
-
|
|
Secretin Receptor
|
Cancer
|
|
Peptide C105Y TFA, a synthetic and cell-penetrating peptide based on the amino acid sequence corresponding to residues 359-374 of α1-antitrypsin, enhances gene expression from DNA nanoparticles [1].
|
-
- HY-119910A
-
|
(E/Z)-XIB4035
|
GDNF Receptor
|
Neurological Disease
|
|
Aminoquinol is a GFRα-1 agonist. Aminoquinol exhibits neurotrophic effects similar to GDNF and induces Ret autophosphorylation in Neuro-2A cells. Aminoquinol can be used in research related to Parkinson's disease [1].
|
-
- HY-121186
-
-
- HY-120358
-
-
- HY-114794
-
-
- HY-124219
-
|
17-Phenoxy trinor PGF2α ethyl amide
|
Prostaglandin Receptor
|
Others
|
|
17-Phenoxy trinor prostaglandin F2α ethyl amide (17-Phenoxy trinor PGF2α ethyl amide) is an analog of Bimatoprost (HY-12956). 17-Phenoxy trinor prostaglandin F2α ethyl amide is an agonist for Prostaglandin F2α Receptor (FP receptor). 17-Phenoxy trinor prostaglandin F2α ethyl amide is potent to reduce the intraocular pressure and attenuate the glaucoma [1] .
|
-
- HY-117785
-
-
- HY-W411296
-
-
- HY-W400424
-
-
- HY-172807
-
|
|
p38 MAPK
MAPKAPK2 (MK2)
CDK
Wee1
|
Cancer
|
|
p38α inhibitor 9 (Compound 2015) is a p38α inhibitor and blocks p38α’s enzymatic activity with an IC50 lower than 20 nM. p38α inhibitor 9 inhibits MK2 T334 phosphorylation. p38α inhibitor 9 activates Cdc25b and Cdc25c and simultaneously inactivates Wee1, leading to mitotic catastrophe, aneuploidy or polyploidy and DNA damage. p38α inhibitor 9 Inhibits colorectal cancer (CRC) metastasis [1].
|
-
- HY-107826R
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
5α-Cholestan-3-one (Standard) is the analytical standard of 5α-Cholestan-3-one. This product is intended for research and analytical applications. 5α-Cholestan-3-one is an endogenous metabolite.
|
-
- HY-Y0191
-
-
- HY-12836A
-
|
|
IFNAR
|
Inflammation/Immunology
|
|
IFN alpha-IFNAR-IN-1 hydrochloride is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR. IFN alpha-IFNAR-IN-1 hydrochloride inhibits modified Vaccinia virus ankara (MVA)-induced IFN-α responses in murine bone-marrow-derived, Flt3- L-differentiated pDC cultures (BM-pDCs) (IC50=2-8 μM) [1].
|
-
- HY-123349
-
|
|
Drug Metabolite
|
Cardiovascular Disease
|
|
5α-Hydroxy-6-keto cholesterol is major metabolite of β-epoxide (5α,6β-epoxycholesterol) during direct exposure of intact cultured human bronchial epithelial cells (16-HBE) to ozone. 5α-Hydroxy-6-keto cholesterol inhibits cholesterol synthesis with an IC50 of 350 nM [1].
|
-
- HY-13331
-
|
Cortexolone 17 Alpha-propionate; Cortexolone 17α-propionate; CB-03-01
|
Androgen Receptor
|
Endocrinology
|
|
Clascoterone (Cortexolone 17 alpha-propionate;Cortexolone 17α-propionate;CB-03-01) is a new topical and peripherally selective androgen antagonist.
|
-
- HY-163433
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-57 (Compound 10c) is a competitive and orally active α-glucosidase inhibitor with an IC50 value of 0.180 μM and a Ki of 0.15 μM. α-Glucosidase-IN-57 can reduce fasting and overall blood glucose levels in mice, and can be used for anti-diabetes research [1].
|
-
- HY-113209
-
|
|
Endogenous Metabolite
|
Others
|
|
8-Isoprostaglandin F2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. 8-Isoprostaglandin F2α is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. 8-Isoprostaglandin F2α is a weak TP receptor agonist in vascular smooth muscle.
|
-
- HY-169411
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-77 (Compound H7) is a non-competitive inhibitor for α-glucosidase with an IC50 of 1.25 μM. α-Glucosidase-IN-77 lowers blood glucose levels, improves glucose tolerance, regulates intestinal microbiota, and exhibits hepatoprotective effect in mouse type 2 diabetes model [1].
|
-
- HY-N2847
-
|
|
Others
|
Others
|
|
alpha-Isowighteone is a Flavonoids product that can be isolated from the roots of Sophora flavescens [1].
|
-
- HY-N12982
-
|
|
Others
|
Others
|
|
α-Calacorene is an aromatic sesquiterpene hydrocarbon that can be isolated from Reunion vetiver [1].
|
-
- HY-N11671
-
|
|
Others
|
Others
|
|
9α-Hydroxymatrine is a quinolizidine alkaloid that can be found in the leaves of Sophora macrocarpa [1].
|
-
- HY-145678
-
-
- HY-N8758
-
|
|
Others
|
Others
|
|
α-Onocerin diacetate is a Triterpenoids product that can be isolated from the herbs of Lycopodium cernuum L. [1].
|
-
- HY-N2846
-
|
|
Others
|
Others
|
|
α-Epoxydihydroartemisinic acid is a Sesquiterpenoids product that can be isolated from the herbs of Artemisia annua L. [1].
|
-
- HY-P2324
-
|
|
Bacterial
HIF/HIF Prolyl-Hydroxylase
Antibiotic
|
Infection
Cancer
|
|
Gramicidin A is a peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis. Gramicidin A is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. Gramicidin A induces degradation of hypoxia inducible factor 1 α (HIF-1α) .
|
-
- HY-N5123
-
|
|
Others
|
Others
|
|
α-L-Rhamnose is a terminal residue of steviol glycosides Dulcoside A and Dulcoside B. α-L-Rhamnose recognizing lectin site of human dermal fibroblasts functions as a signal transducer: modulation of Ca 2+ fluxes and gene expression [1] .
|
-
- HY-N8229
-
|
|
Others
|
Inflammation/Immunology
|
|
7β,15α,20-Trihydroxy-3,11,23-trioxo-5α-lanosta-8-en-26-oic acid is a triterpenoid compound found in Ganoderma lucidum. 7β,15α,20-Trihydroxy-3,11,23-trioxo-5α-lanosta-8-en-26-oic acid may exhibit anti-inflammatory activity and holds potential for research in inflammatory diseases [1].
|
-
- HY-N2850
-
|
5α-Stigmasta-7,22-dien-3β-ol, acetate; Spinasteryl acetate
|
Others
|
Others
|
|
α-Spinasterol acetate (5α-Stigmasta-7,22-dien-3β-ol, acetate) is a Sesquiterpenoids product that can be isolated from the roots of Trigonostemon chinensis Merr. [1].
|
-
- HY-N2743
-
|
7α-Hydroxystigmasterol; Stigmast-5,22E-diene-3β,7α-diol
|
Others
|
Others
|
|
(3β,7α,22E)-Stigmasta-5,22-diene-3,7-diol (7α-Hydroxystigmasterol) is a Triterpenoids product that can be isolated from the herbs of Glochidion puberum L. [1].
|
-
- HY-11048
-
NS11394
3 Publications Verification
|
GABA Receptor
|
Neurological Disease
|
|
NS11394 is an orally active and unique subtype-selective GABAA positive allosteric receptor (PAM), with a Ki of ~0.5 nM. NS11394 shows a selectivity profile in the order of GABAA-5 > α3 > α2 > α1-containing receptors. NS11394 has anxiolytic and anti-inflammatory properties [1] .
|
-
- HY-N2666
-
|
|
VEGFR
|
Cancer
|
|
5α-Hydroxycostic acid, a eudesmane-type sesquiterpene, is isolated from the herb Laggera alata. 5α-Hydroxycostic acid inhibits angiogenesis and suppresses breast cancer cell migration through regulating VEGF/VEGFR2 and Ang2/Tie2 pathways [1].
|
-
- HY-144696
-
|
|
DYRK
|
Neurological Disease
|
|
Dyrk1A/α-synuclein-IN-2 (Compound b20) is a dual Dyrk1A and α-synuclein aggregation inhibitor with an IC50 of 7.8 µM for α-synuclein. Dyrk1A/α-synuclein-IN-2 has high predictive CNS penetration and neuroprotective effect [1].
|
-
- HY-147832
-
|
|
Eukaryotic Initiation Factor (eIF)
|
Cancer
|
|
EIF2α activator 2 (Compound 1) is an activator of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation. EIF2α activator 2 exhibits high potency in SRB cell proliferation assays (IC50=0.46 μM). EIF2α activator 2 exhibits antiproliferative activity againist K562 and PBMC cells with IC50s of 4.79 and 10.52 μM, respectively [1].
|
-
- HY-160529
-
|
|
nAChR
|
Neurological Disease
|
|
α7 nAChR Modulator-2 (Compound 7b) is a α7 nAChR positive allosteric modulator (PAM) with an EC50 of 2.1 μM. α7 nAChR Modulator-2 can be used for the research of cognitive disorders [1].
|
-
- HY-P2762
-
|
|
Amylases
|
Others
|
|
α-Amylase from Aspergillus oryzae is an amylase. α-Amylase from Aspergillus oryzae can be used for various biochemical studies [1].
|
-
- HY-18733
-
-
- HY-W014049
-
|
|
NO Synthase
|
Others
|
|
N'-Nitro-D-arginine, a nitric oxide synthesis inhibitor, also is a vasodilator that relaxes the smooth muscles and increases blood flow to the penis, improving erections. N'-Nitro-D-arginine also inhibits neutrophil migration by blocking receptors for tumour necrosis factor alpha (TNFα) and interleukin 8 (IL8) [1].
|
-
- HY-126304A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Glycerophosphoric acid (disodium salt hydrate) (α and β mixture) is a complex contains α and β Glycerophosphoric acid isomers.
|
-
- HY-148318
-
|
|
Casein Kinase
|
Cancer
|
|
CK2α-IN-1 (compound 2) is a selective CK2α inhibitor (IC50=7.0 µM; Ki=1.6 µM) that exhibits a non-ATP-competitive mode of action. CK2α-IN-1 exhibits good potential for anticancer studies [1].
|
-
- HY-158037
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-55 (Compound 8g) is an orally active and competitive alpha-glucosidase inhibitor, with IC50 and Ki values of 12.1 and 9.66 µM, respectively. α-Glucosidase-IN-55 can be used for the research into type 2 diabetes mellitus (T2DM) to improve blood sugar control and metabolic health [1].
|
-
- HY-168760
-
-
- HY-131171
-
|
3β,5α-NET
|
Drug Derivative
|
Others
|
|
3β,5α-Tetrahydronorethisterone is a tetrahydro derivative of norethindrone (NET) [1].
|
-
- HY-W039897
-
-
- HY-149532
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-33 (compound 7c) is a potent α-glucosidase inhibitor (IC50: 2.39 μM) and can be used in the study of type 2 diabetes and hyperglycemia [1].
|
-
- HY-146305
-
-
- HY-149533
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-34 (compound 7f) is a potent α-glucosidase inhibitor (IC50: 2.90 μM) and can be used in the study of type 2 diabetes and hyperglycemia [1].
|
-
- HY-N0548
-
|
|
Glutathione S-transferase
|
Cancer
|
|
α-Angelica lactone is a naturally occurring anticarcinogen and an vinylogous nucleophile. α-Angelica lactone can give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic trapping at the γ-carbon. α-Angelica lactone exerts strong chemoprotective effects by selective enhancement of glutathione-S-thansferase (GST) and UDP-glucononosyltransferase (UGT) detoxification enzymes [1] .
|
-
- HY-B0532S
-
-
- HY-B0225BR
-
|
L-(-)-α-Methyldopa hydrate (Standard); MK-351 hydrate (Standard)
|
Reference Standards
Adrenergic Receptor
Endogenous Metabolite
|
Cardiovascular Disease
Endocrinology
|
|
Methyldopa (hydrate) (Standard) is the analytical standard of Methyldopa (hydrate). This product is intended for research and analytical applications. Methyldopa hydrate (L-(-)-α-Methyldopa hydrate), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrate is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system [1] .
|
-
- HY-150692
-
|
|
Estrogen Receptor/ERR
|
Cancer
|
|
Estrogen receptor α antagonist 1 (compound 35) is a highly selective antagonist of estrogen receptor α, with IC50s of 0.02, 6.55 and 7.73 μM for estrogen receptor α, estrogen receptor β and MCF-7 cells, respectively. Estrogen receptor α antagonist 1 can be used for the research of cancer [1].
|
-
- HY-W037875
-
|
|
Others
|
Others
|
|
α-Acetamidocinnamic acid is a Alkaloids product that can be isolated from the barks of Cinnamomum cassia Presl [1].
|
-
- HY-N1605
-
|
|
Others
|
Others
|
|
17α-Neriifolin is a compound isolated from a methylene chloride extract of the seeds of Cerbera odollam [1].
|
-
- HY-118566
-
-
- HY-N1026
-
|
|
Others
|
Others
|
|
(-)-12α-Hydroxyevodol is a compound isolated from the fruit of Evodia rutaecarpa BENTHAM (Rutaceae) [1].
|
-
- HY-N12341
-
|
|
Others
|
Others
|
|
17α-Deacetyltanghinin is monoxide that can be isolated from? the airdried leaves of Cérbera odollam [1].
|
-
- HY-N2701
-
|
|
Others
|
Others
|
|
6α-Hydroxynidorellol is a Diterpenoids product that can be isolated from the herbs of Callicarpa macrophylla [1].
|
-
- HY-N1027
-
|
|
Others
|
Others
|
|
12α-Hydroxygrandiflorenic acid is a compound isolated from the whole plant of Wedelia chinensis (Osbeck.) [1].
|
-
- HY-P2601A
-
|
|
CGRP Receptor
|
Others
|
|
Tyr-α-CGRP (human) TFA is an N-terminally extended human α-CGRP analog. Tyr-α-CGRP (human) TFA can bind to membrane preparations from rat brain and spleen with IC50 values of 0.2 nM and 0.5 nM, respectively, and induce positive chronotropic and inotropic effects in isolated guinea pig right and left atria with EC50 values of 282 nM and 74 nM, respectively. Tyr-α-CGRP (human) TFA also inhibits contractile responses in rat vas deferens with an EC50 value of 1.9 nM [1] .
|
-
- HY-147668
-
|
|
α-synuclein
|
Neurological Disease
|
|
α-Synuclein inhibitor 6 (compound 3ge) is a potent and BBB-penetrated inhibitor of α-Synuclein (α-Syn) aggregation, with an IC50 of 1.70 μM and inhibition ratio at 30 μM of 94.4% [1].
|
-
- HY-147666
-
|
|
α-synuclein
|
Neurological Disease
|
|
α-Synuclein inhibitor 4 (compound 3gh) is a potent and BBB-penetrated inhibitor of α-Synuclein (α-Syn) aggregation, with an IC50 of 0.98 μM and inhibition ratio at 30 μM of 91.2% [1].
|
-
- HY-147777
-
|
|
Bacterial
DNA/RNA Synthesis
|
Infection
|
|
14α-Demethylase/DNA Gyrase-IN-2 (Compound 6a) is a potent inhibitor of 14α-Demethylase/DNA Gyrase. 14α-Demethylase/DNA Gyrase-IN-2 has antimicrobial activities [1].
|
-
- HY-147669
-
|
|
α-synuclein
|
Neurological Disease
|
|
α-Synuclein inhibitor 7 (compound 3gf) is a potent and BBB-penetrated inhibitor of α-Synuclein (α-Syn) aggregation, with an IC50 of 1.95 μM and inhibition ratio at 30 μM of 85.8% [1].
|
-
- HY-169288
-
|
|
α-synuclein
|
Neurological Disease
|
|
α-Synuclein modulator 1 (Compound 7k) is a modulator for α-synuclein. α-Synuclein modulator 1 exhibits a maximal absorption and emission wavelength of 386 and 603 nm in ACN/PBS (1:1) buffer [1].
|
-
- HY-147667
-
|
|
α-synuclein
|
Neurological Disease
|
|
α-Synuclein inhibitor 5 (compound 4aa) is a potent and BBB-penetrated inhibitor of α-Synuclein (α-Syn) aggregation, with an IC50 of 1.22 μM and inhibition ratio at 30 μM of 94.3% [1].
|
-
- HY-120974
-
|
|
GLUT
|
Metabolic Disease
|
|
α-Lipoic Acid Derivative 1 (Compound AN-7) is an α-lipoic acid derivative that enhances glucose transport in skeletal muscle by releasing active α-lipoic acid (LA), significantly improving glucose metabolism. In L6 skeletal muscle cells, α-Lipoic Acid Derivative 1 significantly increases glucose transport rates, approximately 12 times more potent than the parent compound α-lipoic acid (HY-N0492). In a mild diabetic mouse model, 10 mg/kg of α-Lipoic Acid Derivative 1 administered for two weeks significantly reduced blood glucose levels by 39%. α-Lipoic Acid Derivative 1 shows significant potential in research related to glucose metabolism in diabetes [1].
|
-
- HY-154540
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
Alpha-5-Methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc [1].
|
-
- HY-100999
-
|
|
Histamine Receptor
|
Neurological Disease
|
|
(R)-(-)-α-Methylhistamine dihydrobromide is a potent, selective and brain-penetrant agonist of H3 histamine receptor, with a Kd of 50.3 nM [1] . (R)-(-)-α-Methylhistamine dihydrobromide can enhance memory retention, attenuates memory impairment in rats .
|
-
- HY-113062
-
|
20-OH-P
|
Endogenous Metabolite
Cytochrome P450
|
Endocrinology
Cancer
|
|
20α-Dihydroprogesterone is the metabolite of Progesterone (HY-N0437). 20α-Dihydroprogesterone inhibits cell proliferation and migration in breast tissue. 20α-Dihydroprogesterone inhibits aromatase in cell MCF-7aro with IC50 about 5 μM [1].
|
-
- HY-W010934S
-
-
- HY-N9280
-
|
|
Others
|
Others
|
|
ent-11α-Hydroxyabieta-8(14),13(15)-dien-16,12α-olide (compound 12) is a natural bioactive diterpenoid found in the roots of Euphorbia fischeriana [1].
|
-
- HY-W087913
-
|
|
Biochemical Assay Reagents
|
Others
|
|
alpha-Naphtholphthalein is an indicator that is light yellow at pH 6 and gradually shows a clear color change with increasing pH to light green-green-blue. alpha-Naphtholphthalein can be impregnated into cotton-blend fabrics and used to develop medical supplies for wound pH monitoring, such as medical gauze, hospital gowns and compression bandages [1].
|
-
- HY-147708
-
|
|
Calcium Channel
|
Cancer
|
|
T-Type calcium channel inhibitor 2 (compound 6g) is a potent T-type calcium channel inhibitor with IC50s of 31.0, 83.1, 69.3 µM for Cav3.1 (α1G), Cav3.2 (α1H), Cav3.3 (α1I) (α1H), respectively. T-Type calcium channel inhibitor 2 shows cytotoxicity for A549, HCT-116 cells with IC50s of 5.0, 6.4 µM, respectively [1].
|
-
- HY-117580R
-
|
OH-PRED (Standard)
|
Reference Standards
Drug Metabolite
|
Inflammation/Immunology
|
|
16α-Hydroxyprednisolone (OH-PRED) (Standard) is the analytical standard of 16α-Hydroxyprednisolone. This product is intended for research and analytical applications. 16α-Hydroxyprednisolone is a stereoselective metabolite of the 22(R) epimer of the glucocorticoid Budesonide (HY-13580). 16α-Hydroxyprednisolone formation is catalyzed by isoenzymes within the cytochrome P450 3A (CYP3A) subfamily. 16α-Hydroxyprednisolone formation can be inhibited by antibodies targeting the CYP3A subfamily [1] .
|
-
- HY-159938
-
|
|
p38 MAPK
Apoptosis
Bcl-2 Family
MDM-2/p53
Caspase
|
Cancer
|
|
p38α inhibitor 6 (compound 19) is a p38α inhibitor with the IC50 of 0.68 μM. p38α inhibitor 6 induces cell apoptosis and arrests cell cycle at G0 and G2/M phase. p38α inhibitor 6 decreases the TNF-α concentration as well as increased the expression of tumor suppressor gene p53, Bax/BCL-2 ratio and caspase 3/7 [1].
|
-
- HY-114364S
-
-
- HY-114423
-
-
- HY-D1530
-
|
|
Fluorescent Dye
|
Others
|
|
4-Methylumbelliferyl-N-acetyl-α-D-glucosaminide is a fluorogenic substrate for detecting α-N-acetylglucosaminidase [1].
|
-
- HY-118714S
-
|
U 40125-d5; Alpha-Hydroxyalprazolam-d5
|
Isotope-Labeled Compounds
|
Others
|
|
α-Hydroxy alprazolam-d5 (U 40125-d5; alpha-Hydroxyalprazolam-d5) is the deuterium labled α-hydroxy alprazolam (HY-118714).
|
-
- HY-116701
-
|
|
Thyroid Hormone Receptor
|
Others
|
|
A 274 is an amiodarone analogue that has the activity of inhibiting the binding of T3 to α1- and β1-thyroid hormone receptors in vitro. Its IC50 values for inhibition of α1-T3R and β1-T3R are certain values (depending on the specific experimental results).
|
-
- HY-E70301
-
|
ST8SIA4
|
Endogenous Metabolite
|
Cancer
|
|
ST8 alpha-2,8-Sialyltransferase 4 (ST8SIA4) is a sialyltransferase that participates in the sialylation mechanism. ST8 alpha-2,8-Sialyltransferase 4 has also been implicated in breast cancer development and mediates cell proliferation and invasion of cancer cells in a sialyltransferase-dependent manner [1].
|
-
- HY-E70302
-
|
ST8SIA6
|
Endogenous Metabolite
|
Inflammation/Immunology
Cancer
|
|
ST8 alpha-2,8-Sialyltransferase 6 (ST8SIA6) is a sialyltransferase that generates α2,8-linked disialic acids, which bind to mouse Siglec-E and human Siglec-7 and -9, and accelerates tumor growth by suppressing anti-tumor immune responses [1].
|
-
- HY-33549
-
|
|
Tyrosine Hydroxylase
|
Neurological Disease
Cancer
|
|
α-Methyl-p-tyrosine is a competitive inhibitor of tyrosine hydroxylase, which converts tyrosine into DOPA. α-Methyl-p-tyrosine is also an orally active inhibitor of catecholamine synthesis, inhibiting the hydroxylation of tyrosine into DOPA. α-Methyl-p-tyrosine can be used in research related to epilepsy, glaucoma, cancer, and other related diseases [1] .
|
-
- HY-117580
-
|
OH-PRED
|
Drug Metabolite
|
Inflammation/Immunology
|
|
16α-Hydroxyprednisolone (OH-PRED) is a stereoselective metabolite of the 22(R) epimer of the glucocorticoid Budesonide (HY-13580). 16α-Hydroxyprednisolone formation is catalyzed by isoenzymes within the cytochrome P450 3A (CYP3A) subfamily. 16α-Hydroxyprednisolone formation can be inhibited by antibodies targeting the CYP3A subfamily [1] .
|
-
- HY-147778
-
|
|
Bacterial
DNA/RNA Synthesis
|
Infection
|
|
14α-Demethylase/DNA Gyrase-IN-1 (Compound 7c) is a potent inhibitor of 14α-Demethylase/DNA Gyrase. 14α-Demethylase/DNA Gyrase-IN-1 has antimicrobial activities [1].
|
-
- HY-E70300
-
|
|
Endogenous Metabolite
|
Others
|
|
ST8 alpha-2,8-Sialyltransferase 8B (ST8SIA8 II) is a sialyltransferase that catalyzes the synthesis of α2,8-polysialic acid (polySia) glycans [1].
|
-
- HY-P4704
-
|
|
α-synuclein
|
Neurological Disease
|
|
α-Synuclein (61-95) (human) is the hydrophobic core region of α-synuclein, and induces neuronal cell death. α-Synuclein (61-95) (human) can be used for research of neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD) [1] .
|
-
- HY-118599
-
|
|
Prostaglandin Receptor
|
Others
|
|
Prostaglandin F2α ethyl amide is an analog of Prostaglandin F2α (HY-12956). Prostaglandin F2α ethyl amide is supposed to be potent lowering intraocular pressure (IOP) for its N-ethyl amide group, like Bimatoprost (HY-B0191) [1].
|
-
- HY-N3879
-
|
|
Others
|
Others
|
|
Eudesm-4(14)-ene-3α,11-diol (compound 2) is a sesquiterpenoid. Eudesm-4(14)-ene-3α,11-diol can be isolated from Neocallitropsis Pancheri Florin [1].
|
-
- HY-N3825
-
|
|
Apoptosis
|
Cancer
|
|
ent-Kaurane-3α,16β,17-triol (Compound 3) is an anticancer agent. ent-Kaurane-3α,16β,17-triol induces apoptosis in HCT116 cells [1].
|
-
- HY-N3604
-
|
2β,9α-Clovanediol; 2β,9α-Dihydroxyclovane; Clovane-2β,9α-diol
|
Others
|
Others
|
|
Clovanediol (2β,9α-Clovanediol) is a product that can be isolated from [1].
|
-
- HY-149654
-
-
- HY-124463
-
-
- HY-113208
-
|
13,14-Dihydro-15-keto-PGF2α
|
Endogenous Metabolite
|
Others
|
|
13,14-Dihydro-15-keto Prostaglandin F2α (13,14-Dihydro-15-keto-PGF2α) is an endogenous metabolite present in Blood that can be used for the research of Pregnancy [1] .
|
-
- HY-W013696
-
|
Alpha-D-Cellobiose octaacetate, 98%
|
Biochemical Assay Reagents
|
Others
|
|
α-D-Cellobiose octaacetate is used as a substrate for glycosidases and in glycobiology research.
|
-
- HY-103413
-
|
|
Dopamine Receptor
|
Neurological Disease
|
|
Eticlopride hydrochloride, a selective dopamine D2‐like receptor antagonist, exhibits high affinity for dopamine D2, α1‐adrenergic, α2‐adrenergic, 5HT1, 5HT2 receptors with Kis of 0.09, 112, 699, 6220, and 830 nM, respectively. Eticlopride hydrochloride is an antipsychotic agent [1].
|
-
- HY-121129
-
|
FLB-131
|
Dopamine Receptor
|
Neurological Disease
|
|
Eticlopride, a selective dopamine D2‐like receptor antagonist, exhibits high affinity for dopamine D2, α1‐adrenergic, α2‐adrenergic, 5HT1, 5HT2 receptors with Kis of 0.09, 112, 699, 6220, and 830 nM, respectively. Eticlopride is an antipsychotic agent [1].
|
-
- HY-16560
-
|
Campathecin; (S)-(+)-Camptothecin; CPT
|
Topoisomerase
ADC Cytotoxin
MicroRNA
Influenza Virus
Apoptosis
Fungal
Antibiotic
|
Infection
Cancer
|
|
Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM [1]. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells .
|
-
- HY-N1032
-
|
|
Others
|
Others
|
|
(+)-12α-Hydroxyisodrimenin (compound 7) is a drimanic sesquiterpene that can be found in sponge Dysidea fusca [1].
|
-
- HY-N9167
-
|
|
Others
|
Others
|
|
6α-Hydroxyhispanone is a Diterpenoids product that can be isolated from the aerial parts of Leonurus japonicus [1].
|
-
- HY-N2992
-
|
|
RAR/RXR
|
Cancer
|
|
16α-Hydroxytrametenolic acid, a natural triterpene, is a potential retinoid X receptor (RXR) selective agonist [1].
|
-
- HY-114744
-
-
- HY-156750
-
-
- HY-155030
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-25 (Compound (R)-8k) is a competitive inhibitor of α-glucosidase, with an IC50 of 1.19μM and can be used for anti-diabetic research [1].
|
-
- HY-157958
-
|
|
nAChR
|
Neurological Disease
|
|
α7 nAChR modulator-3 (Compound 6p) is a α7 nAChR positive allosteric Modulator with a IC50 value of 1.3 μM. α7 nAChR Modulator-3 can be used to inhibit auditory gating defects in a mouse schizophrenic model [1].
|
-
- HY-E70408
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
12α-Hydroxysteroid dehydrogenase, bacillus sphaericus is a dehydrogenase expressed in Bacillus sphaericus. 12α-Hydroxysteroid dehydrogenase, bacillus sphaericus is NAD-dependent and is active on both bound and unbound bile salts. This enzyme can be used to measure the concentration of 12α-hydroxy bile acids in serum [1].
|
-
- HY-P3766
-
|
|
PKC
|
Others
|
|
Protein kinase C α peptide (TFA) is a peptide of PKC-α. PKC-α acts as a lipid-dependent ser/thr protein kinase, can modulate various cellular processes, including cell survival, proliferation, differentiation, migration, adhesion and so on [1].
|
-
- HY-W716866
-
|
10α-Hydroxy-Δ9'11-hexahydrocannabinol
|
Cannabinoid Receptor
Drug Metabolite
|
Neurological Disease
|
|
10α-hydroxy-exo-THC is a cannabinoid compound, a metabolite of Δ9-THC, and can be found in cannabis. 10α-hydroxy-exo-THC can serve as an analytical reference standard for cannabinoid compounds [1] .
|
-
- HY-U00388
-
-
- HY-W779002
-
|
|
Isotope-Labeled Compounds
|
|
|
alpha-D-glucose-13C2-1 is a 13C labeled alpha-D-glucose. alpha-D-glucose is an endogenous metabolite[1].
|
-
- HY-117158
-
|
|
Adrenergic Receptor
|
Others
|
|
SKF 89748 is an α1-adrenergic receptor agonist with the activity of inhibiting food and water intake. SKF 89748 inhibits food and water intake in adult male rats with an ED50 of 0.37mg/kg for inhibiting food intake.
|
-
- HY-153002
-
-
- HY-W742040
-
-
- HY-W725184
-
-
- HY-168422
-
-
- HY-145512
-
-
- HY-168421
-
-
- HY-168812
-
-
- HY-155105
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-30 (compound 8c) is a potent, orally active, competitive inhibitor against α-glucosidase, with Ki of 40.0 µM and IC50 value of 49.0 µM. α-Glucosidase-IN-30 is non-cytotoxic against the cancer and normal cell lines MCF-7 and HDF, and can be used for Type 2 diabetes study [1].
|
-
- HY-N10937
-
|
|
Others
|
Others
|
|
2-Desoxypleniradin-L-α-arabinopyranoside, 2-acetate is an active compound. 2-Desoxypleniradin-L-α-arabinopyranoside, 2-acetate can be isolated from Helenium amarum [1].
|
-
- HY-N3824
-
|
|
Others
|
Others
|
|
ent-Atisane-3β,16α,17-triol is a compound that can be isolated from the acetone extract of roots of Euphorbia sieboldiana. ent-Atisane-3β,16α,17-triol is a natural control product [1].
|
-
- HY-W017387
-
|
Sodium 4-methyl-2-oxopentanoate; 2-Ketoisocaproic acid sodium salt
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Sodium α-ketoisocaproate, the transamination product of leucine, stimulates insulin secretion. Sodium α-ketoisocaproate (α-KIC) can either be oxidized to acetyl-CoA and acetoacetate, or it yields leucine through transamination with glutamate, forming α-KG (HY-44134) [1].
|
-
- HY-159179
-
|
|
Integrin
|
Inflammation/Immunology
|
|
α4 integrin receptor antagonist 3 (Compound 11) is an orally active α4integrin receptor antagonist. α4 integrin receptor antagonist 3 can inhibit the adhesion of K562 cells mediated by the interaction between α4β1/VCAM-1 and α4β7/MAdCAM-1, with IC50 values of 130 nM and 2 nM, respectively. α4 integrin receptor antagonist 3 has the potential to be used in the study of dextran sulfate sodium (DSS) colitis mouse model [1].
|
-
- HY-128463S
-
|
|
COX
Reactive Oxygen Species (ROS)
|
Metabolic Disease
|
|
N-tert-Butyl-α-phenylnitrone-d14 is the deuterium labeled N-tert-Butyl-α-phenylnitrone [1]. N-tert-Butyl-α-phenylnitrone is a nitrone-based free radical scavenger that forms nitroxide spin adducts. N-tert-Butyl-α-phenylnitrone inhibits COX2 catalytic activity. N-tert-Butyl-α-phenylnitrone has potent ROS scavenging, anti-inflammatory, neuroprotective, anti-aging and anti-diabetic activities, and can penetrate the blood-brain barrier .
|
-
- HY-113031
-
|
16α-Hydroxy-DHEA; 16α-OH-DHEA; 16α-hydroxy DHEA
|
Cytochrome P450
|
Endocrinology
|
|
16a-Hydroxydehydroisoandrosterone (16α-Hydroxy-DHEA) is a metabolite of the endogenous steroid hormone dehydroepiandrosterone. 16α-hydroxy Dehydroepiandrosterone is formed from dehydroepiandrosterone via 16-hydroxylation by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5 in adult human liver microsomes, as well as by fetal recombinant CYP3A7. It is a precursor to fetal estrogens, including estriol.
|
-
- HY-125348S
-
|
|
Isotope-Labeled Compounds
|
Cancer
|
|
6α-Hydroxy Paclitaxel-d5 is the deuterium labeled 6α-Hydroxy paclitaxel. 6α-Hydroxy paclitaxel is a primary metabolite of Paclitaxel. 6α-Hydroxy paclitaxel retains a time-dependent effect on organic anion-transporting polypeptides 1B1/SLCO1B1 (OATP1B1) with similar inhibition potency to Paclitaxel, whereas it no longer showed time-dependent inhibition of OATP1B3. 6α-Hydroxy paclitaxel can be used for the research of cancer [1].
|
-
- HY-141336
-
|
DL-α-Lipoic acid-NHS
|
PROTAC Linkers
|
Cancer
|
|
α-Lipoic acid-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs [1].
|
-
- HY-113038B
-
|
2-Hydroxyglutarate; 2-Hydroxyglutaric acid; 2-Hydroxypentanedioic acid
|
Histone Demethylase
Endogenous Metabolite
|
Cancer
|
|
α-Hydroxyglutaric acid (2-Hydroxyglutarate) is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases [1].
|
-
- HY-N2842
-
|
|
Others
|
Inflammation/Immunology
|
|
α-Amyrin acetate, a natural triterpenoid, has anti-inflammatory activity, antispasmodic profile and the relaxant effect [1] .
|
-
- HY-P2950
-
|
|
Biochemical Assay Reagents
|
Others
|
|
α-Mannosidase is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-N9048
-
|
|
Others
|
Others
|
|
12α-Methoxygrandiflorenic acid (compound 6) is a compound isolated from the whole plant of Wedelia chinensis (Osbeck.) [1].
|
-
- HY-N1606
-
|
|
Others
|
Others
|
|
17α-Thevebioside is the compound isolated from air-dried leaves of Cerbera manghas and C. odollam [1].
|
-
- HY-P2324A
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Gramicidin A (TFA) is a peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis. Gramicidin A (TFA) is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. Gramicidin A (TFA) induces degradation of hypoxia inducible factor 1 α (HIF-1α) .
|
-
- HY-W127530
-
|
Alpha-Tocopherol phosphate disodium; TocP disodium; Vitamin E phosphate disodium
|
Apoptosis
Reactive Oxygen Species (ROS)
|
Cardiovascular Disease
Cancer
|
|
α-Tocopherol phosphate disodium is an antioxidant that protects against long-wave UVA1 induced cell death and scavenge UVA1 induced ROS in a skin cell model. α-Tocopherol phosphate disodium exhibits angiogenesis-promoting activity [1] .
|
-
- HY-100542R
-
|
Disodium (R)-2-hydroxyglutarate (Standard)
|
Reference Standards
Reactive Oxygen Species (ROS)
ATP Synthase
mTOR
Endogenous Metabolite
|
Neurological Disease
Inflammation/Immunology
Cancer
|
|
D-α-Hydroxyglutaric acid (disodium) (Standard) is the analytical standard of D-α-Hydroxyglutaric acid (disodium). This product is intended for research and analytical applications. D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling [1] .
|
-
- HY-163572
-
|
|
PI4P5K
|
Cancer
|
|
PIP5K1α-IN-1 (Compound 3e) is an inhibitor for phosphatidylinositol 4-phosphate 5-kinase type I α (PIP5K1α) with an IC50 of 0.46 μM [1].
|
-
- HY-131553
-
|
Vitamin E succinate
|
Apoptosis
|
Cancer
|
|
D-α-Tocopherol Succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E. D-α-Tocopherol Succinate inhibits Cisplatin (HY-17394)-induced cytotoxicity. D-α-Tocopherol Succinate can be used for the research of cancer [1] .
|
-
- HY-N15096
-
-
- HY-114749
-
-
- HY-N15093
-
-
- HY-W355140
-
-
- HY-W014168
-
-
- HY-135061
-
-
- HY-N11910
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Kaempferol-3-O-[(6-caffeoyl)-β-glucopyranosyl (1→3) α-rhamnopyranoside]-7-O-α-rhamnopyranoside (Compound 3) is a wound healing agent with dose-dependent wound healing ability. Kaempferol-3-O-[(6-caffeoyl)-β-glucopyranosyl (1→3) α-rhamnopyranoside]-7-O-α-rhamnopyranoside can be used for wound repair research [1].
|
-
![Kaempferol-3-O-[(6-caffeoyl)-β-glucopyranosyl (1→3) α-rhamnopyranoside]-7-O-α-rhamnopyranoside](//file.medchemexpress.com/product_pic/hy-n11910.gif)
- HY-125348
-
|
|
Drug Metabolite
|
Cancer
|
|
6α-Hydroxy paclitaxel is a primary metabolite of Paclitaxel. 6α-Hydroxy paclitaxel retains a time-dependent effect on organic anion–transporting polypeptides 1B1/SLCO1B1 (OATP1B1) with similar inhibition potency to Paclitaxel, whereas it no longer showed time-dependent inhibition of OATP1B3. 6α-Hydroxy paclitaxel can be used for the research of cancer [1].
|
-
- HY-160458
-
|
|
PI3K
|
Others
|
|
PI3Kα-IN-17 (example 4) is a potent inhibitor of PI3Kα .
|
-
- HY-115746
-
-
- HY-162799
-
|
|
Choline Kinase
|
Cancer
|
|
ChoKα inhibitor-6 (compound Fa22) is a less specific ChoKα1 inhibitor with antitumor activity [1].
|
-
- HY-128463
-
-
- HY-161836
-
|
|
Adrenergic Receptor
|
Cardiovascular Disease
|
|
α2AR agonist 1 (compound S6a), a new morpholine-containing pyrimidinone, acts as an agonist of α2-adrenoceptor. α2AR agonist 1 induces a concentration-dependent relaxation on aortic ring pre-contracted with Phenylephrine (HY-B0769; pEC50=6.81). α2AR agonist 1 increases NOx and NO levels in HUVECs [1].
|
-
- HY-E70055
-
|
|
Sialyltransferase
|
Others
|
|
alpha-2,6-Sialyltransferase (Pd26ST) (EC 2.4.99.1) is capable of sialylating both terminal and internal galactose and N-acetylgalactosamine, which producing terminal α2,6-sialosides [1].
|
-
- HY-N2882
-
|
|
HBV
|
Infection
|
|
Apigenin-4'-α-L-rhamnoside is a potent inhibitor of HBV. Apigenin-4'-α-L-rhamnoside inhibits the secretory level of HBV surface antigen (HBsAg) in HepG2.2.15 cells [1].
|
-
- HY-123063
-
|
5α-Petromyzonol; 5α-PZ
|
Endogenous Metabolite
|
Others
|
|
Petromyzonol (5α-Petromyzonol) is a tetrahydroxy stearol produced by the bile of sea lamprey larvae from the bile acid precursor acetylcholic acid. Petromyzonol sulfate acts as a pheromone and oviposition chemical attractant [1].
|
-
- HY-W127740R
-
|
Isomethyl-α-ionone (Standard); α-Isomethylionone (Standard)
|
Biochemical Assay Reagents
Reference Standards
|
Others
|
|
α-Cetone (Standard) is the analytical standard of α-Cetone. This product is intended for research and analytical applications. Isonaline 70 is an industrial solvent that belongs to the family of high flash point aromatic naphtha solvents. It is commonly used in a variety of industries including paints and coatings, adhesives and rubber manufacturing, as a thinner and thinner for resins and polymers. Isonaline 70 has various properties that make it suitable for these applications, including its low viscosity, high solvency and good compatibility with other materials. In addition, it can also be used as a cleaning agent for mechanical equipment.
|
-
- HY-D0817
-
|
Rhodamine 110 chloride; RH110
|
Fluorescent Dye
|
Others
|
|
Rhodamine 110 is a sensitive and selective substrate for assaying proteinases in solution or inside living cells. The excitation wavelength is 498 nm and the emission wavelength is 521 nm [1].
|
-
- HY-B0702
-
|
|
Adrenergic Receptor
|
Cardiovascular Disease
Neurological Disease
|
|
Nicergoline, an ergoline derivative ester of bromonicotinic acid, is a potent, selective and orally active antagonist of α1A-adrenoceptor. Nicergoline has vasodilator effects. Nicergoline also has ameliorative effects on cognitive function in mouse models of Alzheimer's disease [1] .
|
-
- HY-134429
-
|
|
Biochemical Assay Reagents
|
Others
|
|
p-Nitrophenyl α-L-arabinopyranoside is a biochemical reagent. p-Nitrophenyl α-L-arabinopyranoside can be hydrolyzed by recombinant BgaA (rBgaA, isolated from E. coli BL21 (DE3) strain harboring pEBGA29). p-Nitrophenyl α-L-arabinopyranoside has potential application in enzyme activity detection [1] .
|
-
- HY-129397
-
|
BPG; 2,3-Dinor-11β-PGF2α; 2,3-dinor-11-epi PGF2α
|
Prostaglandin Receptor
|
Endocrinology
|
|
2,3-Dinor-11beta-prostaglandin F2alpha (2,3-Dinor-11β-PGF2α) is a metabolite of PGD2. Urinary excretion of 2,3-Dinor-11beta-prostaglandin F2alpha is increased in patients with mast cell activation disease (MCAD) and has been used as a marker of increased PGD2 levels. 2,3-Dinor-11beta-prostaglandin F2alpha levels are also increased in the urine of patients with asthma and are positively correlated with impaired lung function.
|
-
- HY-151203
-
|
|
PKG
|
Cardiovascular Disease
|
|
PKG1α activator 3 is a PKG1α activator (EC50 basal/partial=13/0.52 μM). PKG1α activator 3 shows anti-proliferative effects to smooth muscle cell, and can be used in cardiovascular disease research [1].
|
-
- HY-B0891
-
|
17-Hydroxyprogesterone; 17-OHP
|
Progesterone Receptor
Endogenous Metabolite
|
Cardiovascular Disease
|
|
17α-Hydroxyprogesterone is a steroid hormone. 17α-Hydroxyprogesterone induces ovarian growth and yolk production in female crabs and increases blood pressure in sheep. 17α-Hydroxyprogesterone is mainly used in research related to crustacean reproduction and animal hypertension [1] .
|
-
- HY-W795652
-
-
- HY-W549451
-
-
- HY-N6854A
-
-
- HY-W271517
-
-
- HY-168811
-
-
- HY-W141831
-
-
- HY-168402
-
-
- HY-106617
-
|
|
5-HT Receptor
Adrenergic Receptor
|
Neurological Disease
|
|
Etoperidone, an antidepressant agent, is an orally active serotonin and nor-adrenaline re-uptake antagonist. Etoperidone shows Kd values of 36 nM, 38 nM, 85 nM, and 570 nM for 5-HT2 receptor, α1-adrenergic receptor, 5-HT1A receptor, and α2-adrenergic receptor, respectively [1] .
|
-
- HY-106617A
-
|
|
5-HT Receptor
Adrenergic Receptor
|
Neurological Disease
|
|
Etoperidone hydrochloride, an antidepressant agent, is an orally active serotonin and nor-adrenaline re-uptake antagonist. Etoperidone hydrochloride shows Kd values of 36 nM, 38 nM, 85 nM, and 570 nM for 5-HT2 receptor, α1-adrenergic receptor, 5-HT1A receptor, and α2-adrenergic receptor, respectively [1] .
|
-
- HY-17034AR
-
|
(+)-Medetomidine hydrochloride (Standard); (S)-Medetomidine hydrochloride (Standard)
|
Reference Standards
Adrenergic Receptor
|
Neurological Disease
Endocrinology
Cancer
|
|
Dexmedetomidine (hydrochloride) (Standard) is the analytical standard of Dexmedetomidine (hydrochloride). This product is intended for research and analytical applications. Dexmedetomidine hydrochloride ((+)-Medetomidine hydrochloride) is a potent, selective and orally active agonist of α2-adrenoceptor, with a Ki of 1.08 nM. Dexmedetomidine hydrochloride shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine hydrochloride exhibits anxiolysis, sedation, and modest analgesia effects [1] .
|
-
- HY-12719R
-
|
(+)-Medetomidine (Standard); (S)-Medetomidine (Standard)
|
Reference Standards
Adrenergic Receptor
|
Neurological Disease
Cancer
|
|
Dexmedetomidine (Standard) is the analytical standard of Dexmedetomidine. This product is intended for research and analytical applications. Dexmedetomidine ((+)-Medetomidine) is a potent, selective and orally active agonist of α2-adrenoceptor, with a Ki of 1.08 nM. Dexmedetomidine shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine exhibits anxiolysis, sedation, and modest analgesia effects [1] .
|
-
- HY-116836
-
|
|
p38 MAPK
|
Inflammation/Immunology
|
|
p38α inhibitor 7 (compound 1) is an effective p38α inhibitor with oral efficacy and generally favorable pharmacokinetic properties [1].
|
-
- HY-10003A
-
-
- HY-162677
-
|
|
Adrenergic Receptor
5-HT Receptor
|
Cardiovascular Disease
|
|
MT-1207 is an orally active and selective adrenergic α1 and 5-HT2A receptor antagonist. MT-1207 shows IC50<0.1 nM, 0.15 nM, 1.40 nM and 0.27 nM for α1A, α1B, α1D and 5-HT2A, respectively. MT-1207 achieves an effective blood pressure (BP) reduction in the 2K2C rat model without damaging renal function. MT-1207 is a potent multitarget inhibitor with the potential for vasodilatation research [1].
|
-
- HY-173039
-
|
|
Microtubule/Tubulin
Keap1-Nrf2
Reactive Oxygen Species (ROS)
Apoptosis
|
Cancer
|
|
α-Tubulin polymerization-IN-1 (Compound 8l) is an inhibitor for α-Tubulin polymerization. α-Tubulin polymerization-IN-1 modulates the NRF2/KEAP-1 signaling pathway, induces ROS generation in PC-3 cell, thereby inducing apoptosis in PC-3. α-Tubulin polymerization-IN-1 inhibits the proliferation of PC-3 cell with a GI50 of 0.17 µM, arrests the cell cycle at G2/M phase. α-Tubulin polymerization-IN-1 exhibits antitumor efficacy in mouse model [1].
|
-
- HY-W145554
-
|
Methyl Alpha-L-fucopyranoside
|
Biochemical Assay Reagents
|
Others
|
|
Methyl α-L-Fucopyranoside is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-131089
-
|
|
Drug-Linker Conjugates for ADC
|
Cancer
|
|
MC-VC-PABC-C6-α-Amanitin is an antibody agent conjugate consisting of an anticancer toxin alpha-Amanitin (HY-19610) and a monoclonal antibody MC-VC-PABC-C6. Among them, alpha-Amanitin is a potent inhibitor of RNA polymerase IIα. MC-VC-PABC-C6-α-Amanitin accurately targets HER2 receptors, specifically recognizes HER2-positive tumor cells. It is widely used in breast cancer and gastric cancer research [1].
|
-
- HY-B2193C
-
|
1,4-Alpha-D-Glucan-glucanohydrolase, amy2, PPA, PA
|
Amylases
|
Others
|
|
α-Amylase, Porcine Pancreatic (1,4-alpha-D-Glucan-glucanohydrolase, amy2, PPA, PA) is a biological material or organic compound that can be used in life science research [1] .
|
-
- HY-W009009
-
|
|
GABA Receptor
|
Neurological Disease
|
|
L-838417 is a selective partial agonist at the α2, α3 and α5 subtypes of the GABAA receptor and an antagonist at the α1, with binding Ki values of 0.79 nM, 0.67 nM, 1.67 nM, 267 nM, 2.25 nM and 2183 nM for α1β3γ2, α2β3γ2, α3β3γ2, α4β3γ2, α5β3γ2 and α6β3γ2 [1].
|
-
- HY-W091039S
-
-
- HY-B0141AR
-
|
Alfatradiol(Standard); Epiestradiol(Standard); Epiestrol (Standard)
|
Reference Standards
5 alpha Reductase
Endogenous Metabolite
Bacterial
|
Inflammation/Immunology
|
|
Alpha-Estradiol (Standard) is the analytical standard of Alpha-Estradiol. This product is intended for research and analytical applications. Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia.
|
-
- HY-42354
-
|
(R)-2-Cyclohexyl-2-aminoethanoic acid; D-Cyclohexylglycine; D-α-Aminocyclohexaneacetic acid
|
Amino Acid Derivatives
|
Others
|
|
D-α-Aminocyclohexylacetic acid is a Glycine (HY-Y0966) derivative [1].
|
-
- HY-168594
-
|
|
Glycosidase
NOD-like Receptor (NLR)
|
Neurological Disease
Metabolic Disease
|
|
α-Glucosidase/NLRP3-IN-1 (Compound 8) is a dual inhibitor of α-glucosidase and NLRP3, exhibiting an IC50 of 6.6 μM against α-glucosidase and inhibiting NLRP3 in multiple cell lines at a concentration of 100 μM. α-Glucosidase/NLRP3-IN-1 demonstrates neuroprotective and antidiabetic properties, and can be utilized in relevant research [1].
|
-
- HY-126683
-
|
|
Drug-Linker Conjugates for ADC
|
Cancer
|
|
Mal-C6-α-Amanitin is a agent-linker conjugate for ADC with potent antitumor activity by using α-Amanitin (an RNA polymerase II inhibitor), linked via the ADC linker Mal-C6.
|
-
- HY-N4009
-
|
|
Others
|
Others
|
|
Iriflophenone 2-O-α-rhamnoside can be isolated from the leaves of Aquilaria sinensis. Iriflophenone 2-O-α-rhamnoside has a half-life value of 2.44 min in rats at the administration of 25 mg/kg [1].
|
-
- HY-116704
-
|
|
Potassium Channel
|
Neurological Disease
|
|
11-Deoxyprostaglandin F2α is an activator for TREK-2 channels with EC50 of 0.294 μM. 11-Deoxyprostaglandin F2α inhibits the K2P channel TREK-1 [1].
|
-
- HY-137324
-
|
|
Drug Metabolite
Antibiotic
|
Infection
|
|
α-Apooxytetracycline is a degradation product of Oxytetracycline (HY-B0275). Oxytetracycline is an antibiotic belonging to the tetracycline class [1].
|
-
- HY-125617
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
α-Lipomycin is an acyclic polyene antibiotic isolated from the gram-positive bacterium Streptomyces aureofaciens Tü117 [1].
|
-
- HY-W020658
-
|
|
Biochemical Assay Reagents
|
Others
|
|
L-α-Phosphatidylinositol is one of the components of phospholipids, and under limited hydration conditions, it can form curved membrane interfaces [1].
|
-
- HY-166519
-
|
α‐HPCD (MW 1180)
|
Biochemical Assay Reagents
|
Others
|
|
(2-Hydroxypropyl)-α-cyclodextrin (MW 1180) is a cyclic oligosaccharide derivative that acts as a solubilizer in various experiments.
|
-
- HY-W777046
-
|
|
Biochemical Assay Reagents
|
Others
|
|
4-Nitrophenyl 3-O-α-D-glucopyranosyl-α-D-glucopyranoside is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology [1].
|
-
- HY-W739586
-
|
|
Biochemical Assay Reagents
|
Others
|
|
4-Nitrophenyl 6-O-α-D-mannopyranosyl-α-D-mannopyranoside is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology [1].
|
-
- HY-W699344
-
|
|
Biochemical Assay Reagents
|
Others
|
|
4-Nitrophenyl 2-O-α-D-glucopyranosyl-α-D-glucopyranoside is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology [1].
|
-
- HY-W777041
-
|
|
Biochemical Assay Reagents
|
Others
|
|
4-Nitrophenyl 6-O-α-D-glucopyranosyl-α-D-glucopyranoside is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology [1].
|
-
- HY-113246
-
|
15-keto-PGF2α
|
Prostaglandin Receptor
Endogenous Metabolite
|
Endocrinology
|
|
15-keto-Prostaglandin F2α (15-keto-PGF2α) is a metabolite of Prostaglandin F2α. Prostaglandin F2α. Prostaglandin F2α is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist and plays a key role in the onset and progression of labour [1].
|
-
- HY-169165
-
|
|
Fungal
|
Infection
|
|
14α-Demethylase-IN-1 (compound 2e) is a 14α-demethylase inhibitor and can be used as an antifungal agent. 14α-Demethylase-IN-1 (48 h) exhibits MIC50 values of 2.47 μM, 1.23 μM, 19.70 μM, and 19.70 μM for C. albicans, C. parapsilosis, C. krusei, and C. glabrata, respectively [1].
|
-
- HY-D1710
-
|
|
Microtubule/Tubulin
|
Others
|
|
Anti-α-Tubulin Antibody, AF555 conjugate is a conjugate of mouse anti-α-tubulin monoclonal antibody and the red fluorescent dye Alexa Fluor 555. Anti-α-Tubulin Antibody, AF555 conjugate can be used for the detection of tubulin (Ex/Em: 554/567 nm) [1].
|
-
- HY-14412
-
|
|
p38 MAPK
|
Cancer
|
|
p38α inhibitor 4 (compound 10) is a selective and allosteric p38α inhibitor with an IC50 value of 1.2 μM. p38α inhibitor 4 exhibits no activity against p38β, p38γ, and p38δ [1].
|
-
- HY-160116
-
|
|
Radionuclide-Drug Conjugates (RDCs)
Fluorescent Dye
α-synuclein
|
Neurological Disease
|
|
α-Synuclein aggregate binder 1 (Compound C05-05) is a specific binder for α-synuclein aggregates and can inhibit α-synuclein aggregation. α-Synuclein aggregate binder 1 can be used as a fluorescent probe (excitation wavelength 900 nm, detection wavelength 500-550 nm) for optical imaging, and can also inhibit α-synuclein fibril formation by blocking the aggregation process. α-Synuclein aggregate binder 1 can be used for positron emission tomography (PET) imaging after being labeled with 18F. α-Synuclein aggregate binder 1 can be used for visual diagnosis of brain lesions and mechanism research of neurodegenerative diseases such as Parkinson's disease and Lewy body dementia [1] .
|
-
- HY-168185
-
|
|
Glycosidase
Phosphatase
Amylases
|
Metabolic Disease
|
|
α-glucosidase/PTP1B-IN-1 (compound 8a) is a potent α-glucosidase and PTP1B inhibitor with an IC50 value of 66.3 μM and 47.0 μM, respectively. α-glucosidase/PTP1B-IN-1 exhibits excellent activities against α-amylase with an IC50 of 30.62 μM. α-glucosidase/PTP1B-IN-1 can dock into the active pockets of α-glucosidase and PTP1B. α-glucosidase/PTP1B-IN-1 has potential to reduce the postprandial blood glucose and is used for Type 2 diabetes mellitus [1].
|
-
- HY-131396
-
-
- HY-118608
-
-
- HY-131553R
-
|
Vitamin E succinate (Standard)
|
Reference Standards
Apoptosis
|
Cancer
|
|
D-α-Tocopherol Succinate (Standard) is the analytical standard of D-α-Tocopherol Succinate. This product is intended for research and analytical applications. D-α-Tocopherol Succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E. D-α-Tocopherol Succinate inhibits Cisplatin (HY-17394)-induced cytotoxicity. D-α-Tocopherol Succinate can be used for the research of cancer [1] .
|
-
- HY-W013854
-
|
3β-Hydroxy-5α-androstane
|
Endogenous Metabolite
|
Others
|
|
5α-Androstan-3β-ol (Androstan), a saturated sterol, is a CAR (constitutive androstane receptor) inverse agonist ligand. 5α-Androstan-3β-ol (Androstan) increases the AmB-channel conductance in a concentration dependent manner [1] .
|
-
- HY-W588292S
-
-
- HY-113561
-
|
LL-AF283α
|
Antibiotic
Bacterial
|
Infection
|
|
Biphenomycin A (LL-AF283α) is a cyclic peptide antibiotic that can be found in Streptomyces griseorubiginosus 43708. It has antibacterial activity and can be used in research in the field of anti-infection [1].
|
-
- HY-113209S2
-
|
|
Endogenous Metabolite
Isotope-Labeled Compounds
|
Others
|
|
8-Isoprostaglandin F2α- 13C5 is 13C labeled 8-Isoprostaglandin F2α (HY-113209). 8-Isoprostaglandin F2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. 8-Isoprostaglandin F2α is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. 8-Isoprostaglandin F2α is a weak TP receptor agonist in vascular smooth muscle.
|
-
- HY-113209S1
-
|
|
Endogenous Metabolite
|
Others
|
|
8-iso Prostaglandin F2α-d9 is the deuterium labeled 8-Isoprostaglandin F2α. 8-Isoprostaglandin F2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. 8-Isoprostaglandin F2α is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. 8-Isoprostaglandin F2α is a weak TP receptor agonist in vascular smooth muscle.
|
-
- HY-136001
-
|
|
PROTACs
α-synuclein
|
Neurological Disease
|
|
PROTAC α-synuclein degrader 3 (Compound 5) is a selective α-synuclein PROTAC degrader. PROTAC α-synuclein degrader 3 can promote the ubiquitination and degradation of α-synuclein. PROTAC α-synuclein degrader 3 can be used for Parkinson's disease research (Pink: target protein ligand (HY-W278021); Black: linker; HY-133302; Blue: E3 ligase VHL ligand (HY-112078)) [1].
|
-
- HY-B0192A
-
|
SL 77499-10
|
Adrenergic Receptor
|
Endocrinology
|
|
Alfuzosin (SL 77499-10) hydrochloride is an orally active, selective and competitive α1-adrenoceptor antagonist. Alfuzosin hydrochloride relaxes the muscles of the prostate and bladder neck, aiding in urination. Alfuzosin hydrochloride can be used in study of benign prostatic hyperplasia (BPH) [1] .
|
-
- HY-B0192
-
|
SL 77499
|
Adrenergic Receptor
|
Endocrinology
|
|
Alfuzosin (SL 77499-10) is an orally active, selective and competitive α1-adrenoceptor antagonist. Alfuzosin relaxes the muscles of the prostate and bladder neck, aiding in urination. Alfuzosin can be used in study of benign prostatic hyperplasia (BPH) [1] .
|
-
- HY-W145603
-
|
Phenyl α-D-Glucoside
|
Biochemical Assay Reagents
|
Others
|
|
Phenyl α-D-Glucopyranoside is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-E70097
-
|
|
Endogenous Metabolite
|
Others
|
|
Sialidase (α2-3-6-8-9) is a broadly specific sialidase that cuts linear and branched non-reducing terminal sialic acid residues from glycoproteins, glycopeptides, and oligosaccharides. Sialidase (α2-3-6-8-9) can be used for in vitro and in vivo polysaccharide analysis and characterization as well as complete glycoprotein remodeling [1].
|
-
- HY-168400
-
-
- HY-168411
-
-
- HY-168403
-
-
- HY-137945
-
|
Pheneticillin sodium; α-Phenoxyethylpenicillin sodium
|
Bacterial
|
Infection
|
|
Phenethicillin (α-Phenoxyethylpenicillin) sodium is a Penicillin, and has antimicrobial activity [1].
|
-
- HY-168401
-
-
- HY-W154216
-
-
- HY-153449
-
-
- HY-W560112
-
-
- HY-W355311
-
-
- HY-107819R
-
|
Dihydrocholesterol(Standard); 5α-Cholestanol(Standard); NSC 18188 (Standard)
|
Reference Standards
Endogenous Metabolite
|
Others
|
|
5α-Cholestan-3β-ol (Standard) is the analytical standard of 5α-Cholestan-3β-ol. This product is intended for research and analytical applications. 5α-Cholestan-3β-ol is a derivitized steroid compound.
|
-
- HY-B1203A
-
|
9α-Fludrocortisone acetate; 9α-Fluorcortisol acetate
|
Mineralocorticoid Receptor
|
Cardiovascular Disease
Metabolic Disease
|
|
Fludrocortisone acetate (9α-Fludrocortisone acetate) is an orally active synthetic mineralocorticoid. Fludrocortisone acetate can effectively control sodium retention. Fludrocortisone acetate is used in studies of cardiac injury, adrenal insufficiency and orthostatic hypotension [1] .
|
-
- HY-N9094
-
|
|
Others
|
Others
|
|
8α-Acetoxyarglabin is a Sesquiterpenoids product that can be isolated from the aerial parts of Artemisia Myriantha Wall.Ex Bess. [1].
|
-
- HY-133970
-
|
|
Biochemical Assay Reagents
|
Others
|
|
5α-Cholestane is a biochemical reagent that can be used as a biological material or organic compound for life science related research [1].
|
-
- HY-P10693
-
-
- HY-112535
-
-
- HY-N1030
-
|
12α-Acetoxy-12-deoxo-elliptone
|
Others
|
Others
|
|
12-Deoxo-12α-acetoxyelliptone is a compound isolated from the roots of Derris oblonga [1].
|
-
- HY-114871
-
|
|
GABA Receptor
|
Neurological Disease
|
|
SL651498 is a full agonist of α2 and α3 GABAA receptors, and a partial agonist of α1 and α5 GABAA receptors. SL651498 shows anxiolytic and anticonvulsant activities [1].
|
-
- HY-136935
-
|
|
Adrenergic Receptor
|
Endocrinology
|
|
Alloyohimbine, an alkaloid, is a selective α2-adrenoceptor antagonist with K Dα1, K Dα2 of 0.28 μM and 0.006 μM, respectively [1].
|
-
- HY-168799
-
-
- HY-W357151
-
|
|
Fluorescent Dye
|
Others
|
|
6-Chloro-3-indoxyl-α-D-mannopyranoside is a chromogenic substrate for α-mannosidase resulting in a salmon colored precipitate upon cleavage.
|
-
- HY-48959
-
|
|
Integrin
|
Metabolic Disease
|
|
α7β1 integrin modulator-1 is a potent α7β1 integrin modulator. α7β1 integrin modulator-1 has the potential for the research of muscular dystrophy [1].
|
-
- HY-134664
-
|
|
Cytochrome P450
Monoamine Oxidase
|
Inflammation/Immunology
|
|
8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate is an irreversible CYP2A6 inhibitor with IC50s of 8.64 μM and 22.3 μM with pre-incubation and co-incubaition, respectively. 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate also inhibits MAO-A and MAO-B with IC50s of 60.2 and 38.6 μM, respectively [1].
|
-
- HY-128747R
-
|
|
Reference Standards
Endogenous Metabolite
|
Cardiovascular Disease
Metabolic Disease
Inflammation/Immunology
|
|
α-D-Glucose-1-phosphate disodium (Standard) is the analytical standard of α-D-Glucose-1-phosphate disodium (HY-128747). This product is intended for research and analytical applications.
α-D-Glucose-1-phosphate disodium is used as a starting material for synthesis of glucuronic acid. α-D-Glucose-1-phosphate disodium can be used as a cytostatic compound essential for cardiopathic therapy, as an antibiotic, as an immunosuppressive agent, and as a circulatory system therapy element.
|
-
- HY-W683681
-
-
- HY-114861
-
-
- HY-N7785
-
-
- HY-W130074
-
|
|
Others
|
Others
|
|
α-Pinene oxide is a natural product that can be isolated from Picea abies (L.) Karst [1].
|
-
- HY-17034AS
-
|
(+)-Medetomidine-13C,d3 hydrochloride; (S)-Medetomidine-13C,d3 hydrochloride
|
Isotope-Labeled Compounds
Adrenergic Receptor
|
Neurological Disease
Endocrinology
Cancer
|
|
Dexmedetomidine- 13C,d3 (hydrochloride) is the 13C- and deuterium labeled Dexmedetomidine (hydrochloride). Dexmedetomidine hydrochloride ((+)-Medetomidine hydrochloride) is a potent, selective and orally active agonist of α2-adrenoceptor, with a Ki of 1.08 nM. Dexmedetomidine hydrochloride shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine hydrochloride exhibits anxiolysis, sedation, and modest analgesia effects [1] .
|
-
- HY-146540
-
|
|
HIF/HIF Prolyl-Hydroxylase
Apoptosis
MDM-2/p53
|
Cancer
|
|
GEM-5 is a gemcitabine-based conjugate containing a HIF-1α inhibitor (YC-1) (IC50=30 nM). GEM-5 can significantly down-regulate the expression of HIF-1α and up-regulate the expression of tumor suppressor p53. GEM-5 induces the apoptosis of A2780 cells and inhibits tumor growth [1].
|
-
- HY-N3813
-
|
|
Others
|
Others
|
|
ent-16α,17-Dihydroxyatisan-3-one is a Diterpenoids product that can be isolated from the herbs of Euphorbia Antiquorum. [1].
|
-
- HY-120981S
-
-
- HY-B0661AS1
-
-
- HY-119910
-
|
XIB4035
|
GDNF Receptor
|
Neurological Disease
|
|
(E)-Aminoquinol (XIB4035) is a GFRα-1 agonist. (E)-Aminoquinol has mimic neurotrophic effects of GDNF, and induces Ret autophosphorylation in Neuro-2A cells. (E)-Aminoquinol can be used for research of Parkinson’s disease [1].
|
-
- HY-119910B
-
|
(E/Z)-XIB4035 phosphate
|
GDNF Receptor
|
Neurological Disease
|
|
Aminoquinol ((E/Z)-XIB4035) phosphate is a GFRα-1 agonist. Aminoquinol phosphate exhibits neurotrophic effects similar to GDNF and induces Ret autophosphorylation in Neuro-2A cells. Aminoquinol phosphate can be used in research related to Parkinson's disease [1].
|
-
- HY-134863
-
|
|
Serpin
|
Infection
Inflammation/Immunology
|
|
A1AT modulator 2 (compound 33) is a modulator of A1AT (α-1 antitrypsin) with an IC50 value of ＞1.0 μM and an EC50 value of ＜0.4 μM. A1AT modulator 2 can be used for the research of infection and inflammation [1].
|
-
- HY-16579
-
|
HOE 36-801 hydrochloride
|
GABA Receptor
|
Neurological Disease
|
|
Etifoxine hydrochloride, a non-benzodiazepine GABAergic compound, is a positive allosteric modulator of α1β2γ2 and α1β3γ2 subunit-containing GABAA receptors. Etifoxine hydrochloride reveals anxiolytic and anticonvulsant properties in rodents [1] .
|
-
- HY-B0371
-
|
|
Adrenergic Receptor
|
Cardiovascular Disease
Metabolic Disease
Endocrinology
|
|
Terazosin is a quinazoline derivative and a competitive and orally active α1-adrenoceptor antagonist. Terazosin works by relaxing blood vessels and the opening of the bladder. Terazosin has the potential for benign prostatic hyperplasia (BPH) and high blood pressure treatment [1] .
|
-
- HY-B0661AS
-
-
- HY-119910C
-
|
(E/Z)-XIB4035 triphosphate
|
GDNF Receptor
|
Neurological Disease
|
|
Aminoquinol ((E/Z)-XIB4035) phosphate is a GFRα-1 agonist. Aminoquinol phosphate exhibits neurotrophic effects similar to GDNF and induces Ret autophosphorylation in Neuro-2A cells. Aminoquinol phosphate can be used in research related to Parkinson's disease [1].
|
-
- HY-B0371F
-
|
|
Adrenergic Receptor
|
Cardiovascular Disease
Metabolic Disease
Endocrinology
|
|
Terazosin hydrochloride is a quinazoline derivative and a competitive and orally active α1-adrenoceptor antagonist. Terazosin hydrochloride works by relaxing blood vessels and the opening of the bladder. Terazosin hydrochloride has the potential for benign prostatic hyperplasia (BPH) and high blood pressure treatment [1] .
|
-
- HY-16579A
-
|
HOE 36-801
|
GABA Receptor
|
Neurological Disease
|
|
Etifoxine, a non-benzodiazepine GABAergic compound, is a positive allosteric modulator of α1β2γ2 and α1β3γ2 subunit-containing GABAA receptors. Etifoxine reveals anxiolytic and anticonvulsant properties in rodents [1] .
|
-
- HY-N6913
-
|
|
AMPK
|
Metabolic Disease
|
|
3α-Hydroxymogrol is a triterpenoid isolated from Siraitia grosvenorii Swingle, acts as a potent AMPK activator, and enhances AMPK phosphorylation [1].
|
-
- HY-P4704A
-
|
|
α-synuclein
|
Neurological Disease
|
|
α-Synuclein (61-95) (human) TFA is the hydrophobic core region of α-synuclein, and induces neuronal cell death. α-Synuclein (61-95) (human) TFA can be used for research of neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD) [1] .
|
-
- HY-P1793
-
|
|
Opioid Receptor
Biochemical Assay Reagents
|
Neurological Disease
Inflammation/Immunology
Cancer
|
|
α-Casein (90-95) is a partial agonist of opioid receptors and a copper ion ligand, with opioid activity. α-Casein (90-95) inhibits the secretion of β-hexosaminidase by rat peritoneal mast cells (PMC) with IC50= 0.1 μM. α-Casein (90-95) inhibits the proliferation of prostate cancer cells LNCaP, DU145, and PC3 with IC50 of 0.94 nM, 137 nM, and 6.92 nM, respectively. α-Casein (90-95) activates Gi-like proteins through a membrane-assisted, receptor-independent pathway, or reversibly binds to opioid receptors, inducing intracellular calcium release and conformational changes, and exerts the activity of promoting mast cell secretion and inhibiting tumor cell proliferation. α-Casein (90-95) can be used in the study of the mechanisms of allergic diseases and prostate cancer [1] .
|
-
- HY-W436495
-
|
6,15-Diketo-13,14-dihydro-PGF1α
|
Drug Metabolite
|
Metabolic Disease
|
|
6,15-Diketo-13,14-dihydro prostaglandin F1α (6,15-Diketo-13,14-dihydro-PGF1α) is a metabolite of prostacyclin (PGI2). 6,15-Diketo-13,14-dihydro prostaglandin F1α enhances intracellular cAMP and cholesterol metabolism in bovine arterial smooth muscle cells [1].
|
-
- HY-134442
-
-
- HY-142127S
-
-
- HY-101514
-
|
|
Adrenergic Receptor
|
Cardiovascular Disease
Endocrinology
|
|
β3-AR agonist 1 (compound 15) is a highly potent, selective, and orally available β3-adrenergic receptor (β3-AR) agonist (EC50=18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/β3, and α1A/β3>556-fold) [1].
|
-
- HY-N3802
-
|
Ethyl α-D-galactoside; Ethyl α-D-galactopyranoside
|
Others
|
Others
|
|
Eleutheroside C (Ethyl α-D-galactoside) is a glycoside isolated from the bulbs of Polianthes tuberosa [1].
|
-
- HY-B0648
-
|
17α-Hydroxy-6α-methylprogesterone; U8840
|
Progesterone Receptor
|
Endocrinology
Cancer
|
|
Medroxyprogesterone (17α-Hydroxy-6α-methylprogesterone) is a synthetic human variant of progesterone that is a progesterone receptor agonist with oral activity. Medroxyprogesterone can induce cell proliferation through the PI3K/Akt signaling pathway. Medroxyprogesterone has an inhibitory effect on atherosclerosis in mice. The progesterone agonist activity of Medroxyprogesterone is less effective than Medroxyprogesterone acetate (HY-B0469) [1] .
|
-
- HY-B0757A
-
|
rel-Vitamin E Nicotinate
|
Reactive Oxygen Species (ROS)
Endogenous Metabolite
|
Cardiovascular Disease
|
|
(±)-α-Tocopherol nicotinate, vitamin E - nicotinate, is an orally active fat-soluble antioxidant that prevents lipid peroxidation in cell membranes. (±)-α-Tocopherol nicotinate is hydrolysed in the blood to α -tocopherol and niacin and may be used in studies of related vascular diseases [1] .
|
-
- HY-W558285
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Methyl 3,6-di-O-(α-D-mannopyranosyl)-α-D-mannopyranoside is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology [1].
|
-
- HY-P1860
-
|
|
TNF Receptor
NF-κB
Apoptosis
|
Inflammation/Immunology
Cancer
|
|
TNF-α (31-45), human is a potent NF-kB pathway activator. TNF-αis a proinflammatory cytokine that induces necrosis or apoptosis. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis [1] .
|
-
- HY-W028813
-
-
- HY-123519
-
|
|
Insecticide
|
Infection
|
|
14α-Hydroxy Paspalinine is a paspalinine derivative with antiinsectan activity from the sclerotia of Aspergillus nomius [1].
|
-
- HY-N11670
-
|
|
Others
|
Others
|
|
11(α)-Hydroxynepasaikosaponin k (compound HOSSc) is a saikosaponin that can be found in B. scorzonerifolium Willd [1].
|
-
- HY-N15098
-
|
|
Parasite
|
Infection
|
|
Milbemycin α15 possess a potent antiparasitic activity, including acaricidal, insecticidal and nematocidal activities [1].
|
-
- HY-137944
-
|
|
Apoptosis
|
Endocrinology
|
|
5α-Dihydro levonorgestrel is a metabolite of the synthetic progestin Levonorgestrel (HY-B0257) [1].
|
-
- HY-116795
-
-
- HY-N2797
-
|
|
Others
|
Others
|
|
9-Methoxy-α-lapachone is a Quinones product that can be isolated from the stems of Catalpa ovata [1].
|
-
- HY-N9730
-
|
|
Others
|
Others
|
|
Methyl 2α-hydroxyhardwickiate is a Diterpenoids product that can be isolated from the herbs of lodes cirrhosa [1].
|
-
- HY-N10128
-
|
|
Bacterial
|
Infection
|
|
(8'α,9'β-Dihydroxy)-3-farnesylindole shows strong inhibitory activity (EC50 9.8 μM) against B. subtilis.
|
-
- HY-125626
-
|
8-iso-15-keto PGF2α
|
Prostaglandin Receptor
|
Cardiovascular Disease
|
|
8-iso-15-keto Prostaglandin F2α (8-iso-15-keto PGF2α) is a partial agonist for Thromboxane receptor (TP), which exhibits a vasoconstrictor efficacy with a pD2 of 5.8. 8-iso-15-keto Prostaglandin F2α mediates a weak relaxation of rats aorta rings at high concentration [1].
|
-
- HY-144509S
-
-
- HY-125150
-
-
- HY-103641B
-
|
(2R)-Octyl-2-HG sodium
|
Histone Methyltransferase
|
Others
|
|
(2R)-Octyl-α-hydroxyglutarate (sodium) is the sodium salt form of (2R)-Octyl-α-hydroxyglutarate. (2R)-Octyl-α-hydroxyglutarate has anti-inflammatory effects [1].
|
-
- HY-W703432
-
-
- HY-W339545A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
α-Ketoglutaric acid disodium hydrate, an important dicarboxylic acid, is an intermediate in the tricarboxylic acid cycle (TCC) and amino acid metabolism. α-Ketoglutaric acid disodium hydrate can be used as building block chemical for the chemical synthesis of heterocycles, dietary supplement, component of infusion solutions and wound healing compounds, or as main component of new elastomers with a wide range of interesting mechanical and chemical properties [1].
|
-
- HY-139702
-
|
|
Integrin
|
Cancer
|
|
α5β1 integrin agonist-1, acting as α5β1 integrin agonist, is able to selectively deliver 5-FU into tumor cells, successfully leading to cancer cell death.
|
-
- HY-P3095
-
-
- HY-124175
-
-
- HY-146992S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
α-D-Glucopyranosyl 1-phosphate- 13C (dicyclohexylamine, monohydrate) is the 13C labeled α-D-Glucopyranosyl 1-phosphate [1].
|
-
- HY-W041703
-
|
5-Bromoquinoxalin-6-amine
|
Androgen Receptor
|
Others
|
|
6-Amino-5-bromoquinoxaline is a 2-(arylamino)imidazole derivative and a precursor of α1- and α2-androgen receptor antagonists [1].
|
-
- HY-N4275
-
|
|
Others
|
Cancer
|
|
Oleaside A is a polar cardenolide monoglycoside isolated from Nerium oleander, inhibits the induction of ICAM-1 induced by IL-1α and TNF-α, and has anti-tumor activity [1].
|
-
- HY-144695
-
|
|
DYRK
|
Neurological Disease
|
|
Dyrk1A/α-synuclein-IN-1 (Compound b1) is a dual Dyrk1A and α-synuclein aggregation inhibitor with IC50 values of 177 nM and 10.5 µM, respectively. Dyrk1A/α-synuclein-IN-1 has high predictive CNS penetration and neuroprotective effect [1].
|
-
- HY-168841
-
-
- HY-114333
-
|
1-Octyl 2-oxopentanedioate
|
HIF/HIF Prolyl-Hydroxylase
|
Metabolic Disease
Cancer
|
|
Octyl-α-ketoglutarate (1-Octyl 2-oxopentanedioate) is a stable, cell-permeable form of α-ketoglutarate which accumulates rapidly in HEK293 cells with a dysfunctional tricarboxylic acid (TCA) cycle, stimulating prolyl hydroxylase (PHD) activity. In addition, Octyl-α-ketoglutarate competitively blocks succinate- or fumarate-mediated inhibition of PHD [1].
|
-
- HY-P2988
-
|
Exo-α-sialidase
|
Endogenous Metabolite
|
Infection
|
|
Neuraminidase, Microorganism (Exo-α-sialidase) is an exosialidase, is often used in biochemical studies. Neuraminidase cleaves α-ketosidic linkage between the sialic (N-acetylneuraminic) acid and an adjacent sugar residue. Neuraminidase, derived from mucosal pathogens, is a virulence factor that modifies the host's response to infection [1].
|
-
- HY-137309
-
|
|
HIV
|
Others
|
|
4-Deoxy-4α-phorbol is a tetracyclic diterpene found in E. desmondi. It has been used in the semisynthesis of inhibitors of the HIV-1-induced cytopathic effect on MT-4 cells and 4α-phorbol esters [1].
|
-
- HY-E70057
-
|
ST8Sia VI; GD3 synthase
|
Endogenous Metabolite
|
Metabolic Disease
|
|
alpha-2,8-Sialyltransferase (CstII) (ST8Sia VI) is a member of alpha2,8-sialyltransferase (ST8Sia) family, is often used in biochemical studies. alpha-2,8-Sialyltransferase (CstII) catalyzes elongation of the α2,8-linked oligo/polysialic acid chain on the Sia residue transferred [1].
|
-
- HY-158194
-
|
|
Adrenergic Receptor
|
Cancer
|
|
α2C adrenoceptor agonist 1 (Compound A) is an orally active, highly selective, and non-central nervous system penetrating agonist for the α2C-adrenoceptor, with EC50 and Ki values of 108 nM and 12 nM, respectively. α2C adrenoceptor agonist 1 can be used in the study of nasal congestion [1].
|
-
- HY-N1876
-
|
|
Others
|
Neurological Disease
|
|
Aromadendrane-4β,10α-diol is a sesquiterpene alcohol. Aromadendrane-4β,10α-diol significantly ameliorates the Aβ1-42 peptide-induced memory impairment. Aromadendrane-4β,10α-diol can be used for Alzheimer's disease (AD) research [1].
|
-
- HY-137815
-
|
|
Biochemical Assay Reagents
|
Metabolic Disease
|
|
4-Nitrophenyl α-L-rhamnopyranoside is a commonly used substrate in various biochemical assays to measure the activity of enzymes that hydrolyze rhamnose, such as α-L-rhamnosidase. 4-Nitrophenyl α-L-rhamnopyranoside has unique chemical properties that allow it to be hydrolyzed by these enzymes to form a yellow product called p-nitrophenol. This makes it a useful tool for detecting and quantifying rhamnohydrolase activity in biological samples or microbial cultures.
|
-
- HY-N11499
-
|
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
Myricetin 3-O-α-L-arabinopyranoside is a quercetin derivative and plant flavonoid with antioxidant, antibacterial and antiurease effects. Myricetin 3-O-α-L-arabinopyranoside inhibits A2E photooxidation-induced RPE cell death. Myricetin 3-O-α-L-arabinopyranoside is protective against retinal degeneration and protects against blue light (BL)-induced damage in RPE cells and mouse models [1].
|
-
- HY-B0757AR
-
|
rel-Vitamin E Nicotinate (Standard)
|
Reference Standards
Reactive Oxygen Species (ROS)
Endogenous Metabolite
|
Cardiovascular Disease
|
|
(±)-α-Tocopherol nicotinate (Standard) is the analytical standard of (±)-α-Tocopherol nicotinate. This product is intended for research and analytical applications. (±)-α-Tocopherol nicotinate, vitamin E - nicotinate, is an orally active fat-soluble antioxidant that prevents lipid peroxidation in cell membranes. (±)-α-Tocopherol nicotinate is hydrolysed in the blood to α -tocopherol and niacin and may be used in studies of related vascular diseases[1][2].
|
-
- HY-157255S
-
|
Dimethylpentedrone-d5 hydrochloride
|
Isotope-Labeled Compounds
|
Others
|
|
α-Pyrrolidinopropiophenone-d5 hydrochloride is the deuterium labeled α-Pyrrolidinopropiophenone hydrochloride [1].
|
-
- HY-112769
-
EX229
5 Publications Verification
|
AMPK
|
Metabolic Disease
|
|
EX229, a Benzimidazole derivative, is a potent and allosteric activator of AMP-activated protein kinase (AMPK), with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1 and α1β2γ1 in biolayer interferometry, respectively.
|
-
- HY-155021
-
|
|
α-synuclein
|
Neurological Disease
|
|
PROTAC α-synuclein degrader 5 is a highly selective small-molecule degraders (PROTAC) of α-synuclein aggregates, with an DC50 of 7.51 μM and the highest degradation rate Dmax of 89%. PROTAC α-synuclein degrader 5 contains probe molecule sery308 and E3 ligase ligands. PROTAC α-synuclein degrader 5 can be used for neurological disease research [1].
|
-
- HY-N9950
-
|
|
Others
|
Inflammation/Immunology
|
|
α-D-altro-3-Heptulofuranose is a nature product that could be isolated from the rhizomes of Actinidia kolomikta. α-D-altro-3-Heptulofuranose has anti-inflammatory activity [1].
|
-
- HY-14903
-
|
TZP-101
|
GHSR
Adrenergic Receptor
|
Metabolic Disease
|
|
Ulimorelin (TZP-101) is a ghrelin receptor (GRLN) agonist with an EC50 of 29 nM and a Ki of 16 nM. Ulimorelin is a prokinetic agent and causes vasorelaxation through competitive antagonist action at α1-adrenoceptors. Ulimorelin stimulates intestinal motility and is used for malnutrition [1] .
|
-
- HY-139128
-
-
- HY-N0242R
-
|
|
Reference Standards
PD-1/PD-L1
HIF/HIF Prolyl-Hydroxylase
STAT
|
Inflammation/Immunology
Cancer
|
|
Fraxinellone (Standard) is the analytical standard of Fraxinellone. This product is intended for research and analytical applications. Fraxinellone is isolated from the root bark of the Rutaceae plant, Dictamnus dasycarpus. Fraxinellone is a PD-L1 inhibitor and inhibits HIF-1α protein synthesis without affecting HIF-1α protein degradation. Fraxinellone has the potential to be a valuable candidate for cancer treatment by targeting PD-L1 [1].
|
-
- HY-B0135
-
|
|
NKCC
GABA Receptor
|
Cardiovascular Disease
Metabolic Disease
Cancer
|
|
Furosemide is a potent and orally active inhibitor of Na +/K +/2Cl - (NKCC) cotransporter, NKCC1 and NKCC2 [1]. Furosemide is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema .
|
-
- HY-15484
-
|
Pifithrin hydrobromide; PFTα hydrobromide
|
MDM-2/p53
Aryl Hydrocarbon Receptor
Ferroptosis
Apoptosis
|
Cancer
|
|
Pifithrin-α hydrobromide is a p53 inhibitor which blocks its transcriptional activity and prevents cells from apoptosis. Pifithrin-α hydrobromide is also an aryl hydrocarbon receptor (AhR) agonist.
|
-
- HY-P1071
-
|
Calcitonin gene-related peptide
|
CGRP Receptor
|
Cardiovascular Disease
|
|
α-CGRP(human) (Calcitonin gene-related peptide) is a regulatory neuropeptide of 37 amino acids. α-CGRP(human) is widely distributed in the central and peripheral nervous system. α-CGRP(human) is a potent vasodilator and has inotropic and chronotropic effects [1] .
|
-
- HY-W587927
-
|
|
Drug Intermediate
|
Others
|
|
α-Hydroxymethyl atropine is the impurity, that could be produced in process of Atropine (HY-B1205) synthesis [1].
|
-
- HY-N7752
-
|
|
Others
|
Others
|
|
3α-Hydroxytanshinone IIA (Compound 5) is a compound that can be isolated from the roots of Saluia miltiorrhiza [1].
|
-
- HY-136347
-
-
- HY-N7389B
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
GDP-α-D-mannose disodium is the donor substrate for mannosyltransferases and the precursor of GDP-β-L-fucose. GDP-α-D-mannose disodium gives a competitive inhibition with respect to GTP (Ki 14.7 μM) and an uncompetitive inhibition with respect to mannose-1-P (Ki 115 μM) [1].
|
-
- HY-137055
-
|
|
Others
|
Others
|
|
PF-3774076 is a highly central nervous system (CNS) penetrant, potent, and selective human α1A-adrenoceptor partial agonist. It exhibits good potency and selectivity in multiple binding and functional assays. PF-3774076 increases peak urethral pressure in anesthetized female dogs in a dose-dependent manner via a central mechanism. PF-3774076 affects both the proximal and distal portions of the urethra in vivo. These properties suggest that PF-3774076 may have significant benefit in the treatment of stress urinary incontinence (SUI) as a CNS-penetrant α1A receptor partial agonist. However, despite its partial agonism and selectivity for α1A receptors, PF-3774076 failed to provide adequate safety differences in in vivo models of cardiovascular function. This may be due to the simultaneous activation of both peripheral and central α1A receptors. These data suggest that while central α1A partial agonists may have significant benefit in the treatment of SUI, this class of agents may have difficulty achieving the desired urethral selectivity without affecting cardiovascular function.
|
-
- HY-171818
-
-
- HY-128417S5
-
-
- HY-N14955
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
3-O-α-D-Forosaminyl-(+)-griseusin is a memberof naphthoquinone antibiotic. 3-O-α-D-Forosaminyl-(+)-griseusin is active against Gram-positive bacteria including methicillin-resistant strain of Staphylococcus aureus (MRSA) [1].
|
-
- HY-124242
-
|
|
Drug Derivative
|
Cancer
|
|
(S)-α-Methylbenzyl ricinoleamide (compound (R,S)-3d) is a fatty acid amide. (S)-α-Methylbenzyl ricinoleamide shows antiproliferative activity, inhibits the growth of human ovarian cancer cells NCI-ADR/RES and glioma cells U251 with GI50s of 1.9 μg/mL and 3.6 μg/mL, respectively [1].
|
-
- HY-W681014
-
|
|
5-HT Receptor
Dopamine Receptor
|
Neurological Disease
|
|
5-Fluoro-α-methyltryptamine hydrochloride may cause an increase in intracellular levels of 5-HT followed by an increase in 5-HT release. 5-Fluoro-α-methyltryptamine hydrochloride exhibits EC50 values of 37 nM, 14 nM, 78 nM and 8.47 nM for DA, 5HT, NE and 5-HT2A, respectively [1] .
|
-
- HY-118520
-
|
|
Prostaglandin Receptor
|
Endocrinology
|
|
16-Phenoxy tetranor Prostaglandin F2α methyl ester is a metabolically stable form of Prostaglandin F2α that can binds to FP receptor. 16-Phenoxy tetranor Prostaglandin F2α methyl ester serves as prodrug that can be hydrolyzed to generate bioactive free acid [1].
|
-
- HY-P2519
-
-
- HY-P1758
-
|
IRRP1
|
IFNAR
|
Infection
|
|
IFN-α Receptor Recognition Peptide 1 is a peptide of IFN-α associated with receptor interactions [1].
|
-
- HY-W341713
-
|
|
Drug Intermediate
|
Others
|
|
Hepta-O-acetyl-α-D-lactosyl bromide (Compound 4) is a brominated lactoside. Hepta-O-acetyl-α-D-lactosyl bromide is a synthetic substrate for perfluoroalkyl-labeled lactose lipids [1].
|
-
- HY-105279
-
|
PP 56
|
FGFR
|
Others
|
|
α-Trinositol (PP 56) is an isomer of the intracellular messenger IP3. α-Trinositol can be used in the study of in vitro cytotoxicity and glutamate-induced glial cytotoxic swelling and injury [1].
|
-
- HY-129953A
-
-
- HY-D1486
-
|
|
Fluorescent Dye
|
Others
|
|
4,4-Difluoro-8-(4'-iodophenyl)-1,7-bis-(1'-napthyl)-4-bora-3alpha,4alpha-diaza-s-indacene is a fluorescent dye for DNA sequencing [1].
|
-
- HY-113038
-
|
(R)-2-Hydroxyglutarate; (R)-2-Hydroxyglutaric acid; (R)-2-Hydroxypentanedioic acid
|
Reactive Oxygen Species (ROS)
ATP Synthase
mTOR
Endogenous Metabolite
|
Neurological Disease
Inflammation/Immunology
Cancer
|
|
D-α-Hydroxyglutaric acid ((R)-2-Hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. D-α-Hydroxyglutaric acid increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid binds and inhibits ATP synthase and inhibits mTOR signaling [1] .
|
-
- HY-107819
-
-
- HY-N8971
-
|
16α-Hydroxybauerenol
|
Bacterial
|
Infection
|
|
Bauer-7-ene-3β,16α-diol, a triterpenoid, is a natural product that can be isolated from dried flower buds of Tussilago farfara L. or Petasites tricholobus (Compositae). Bauer-7-ene-3β,16α-diol shows medium antibacterial activity against E. coli [1].
|
-
- HY-P1091
-
|
|
Cannabinoid Receptor
|
Neurological Disease
|
|
Hemopressin is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin exerts antinociceptive action in inflammatory pain models [1] .
|
-
- HY-W103372
-
|
|
Adrenergic Receptor
|
Cardiovascular Disease
|
|
Vasorelaxant agent-2 (Compound 8h) targets α1A-adrenergic receptor with an affinity of pD2=5.4. Vasorelaxant agent-2 exhibits vasodilator activity in rats aortic rings with an EC50 of 0.79 μM [1].
|
-
- HY-12987
-
-
- HY-120296R
-
|
|
Adrenergic Receptor
|
Cardiovascular Disease
|
|
5-Methylurapidil (Standard) is the analytical standard of 5-Methylurapidil. This product is intended for research and analytical applications. 5-Methylurapidil isα1A‐adrenoceptor antagonist. 5-Methylurapidil can be used for the research of cardiovascular diseases such as hypertension and heart failure [1].
|
-
- HY-120270
-
|
|
AMPK
|
Metabolic Disease
|
|
PF-06679142 (Compound 10) is a potent, orally active AMPK activator with an EC50 of 22 nM against α1β1γ1-AMPK. PF-06679142 can be used for diabetic nephropathy research [1].
|
-
- HY-P1294
-
|
|
CRFR
|
Neurological Disease
|
|
α-Helical CRF(9-41) is a competitive CRF2 receptor antagonist with KB of ~100 nM. α-Helical CRF(9-41) is also a partial agonist of CRF1 receptor with an EC50 of 140 nM [1] .
|
-
- HY-W352408
-
-
- HY-W416271
-
-
- HY-B1278A
-
-
- HY-W751322
-
-
- HY-N9691
-
|
α-Curcumene
|
Others
|
Others
|
|
α-curcumene (compound 12) is isolated from the essential oil of rhizomes of Curcuma aromatica and can be synthesized artificially [1].
|
-
- HY-W108801
-
|
|
Biochemical Assay Reagents
|
|
|
α-D-Glucoheptonic acid sodium is a compound that modulates the immune system, has chelating activity, and can be used in the preparation of cleaning agents.
|
-
- HY-W008206
-
|
|
Biochemical Assay Reagents
|
Others
|
|
(±)-Boc-α-phosphonoglycine trimethyl ester is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-141553
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Methyl alpha-eleostearate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-E70062
-
|
Fh8-PmST3
|
Endogenous Metabolite
|
Metabolic Disease
|
|
alpha-2,3-Sialyltransferase (PmST3) (EC 2.4.99.4) is a beta-galactoside. alpha-2,3-Sialyltransferase (PmST3) catalyzes the transfer of sialic acid to carbohydrate groups of glycoproteins and glycolipids [1].
|
-
- HY-171300
-
-
- HY-137490
-
-
- HY-137012
-
-
- HY-N6602
-
-
- HY-N12102
-
|
|
HBV
|
Infection
|
|
Dihydrodehydrodiconiferyl alcohol 9-O-α-L-rhamnopyranoside (compound 1) is a lignan with anti-HBC activity. Dihydrodehydrodiconiferyl alcohol 9-O-α-L-rhamnopyranoside targets HBV surface antigen with IC50s of 0.58 mM (HBsAg) and >2.4 mM (HBeAg). Dihydrodehydrodiconiferyl alcohol 9-O-α-L-rhamnopyranoside can be isolated from star anise [1].
|
-
- HY-P990871
-
|
|
Integrin
|
Others
|
|
Anti-CD11a/LFA-1α Antibody (R7-1) is a kind of mouse IgG1 chimeric antibody, targeting to human CD11a/LFA-1α. The recommend isotype control of Anti-CD11a/LFA-1α Antibody (R7-1): Mouse IgG1 kappa, Isotype Control (HY-P99977).
|
-
- HY-B0385
-
|
FOY
|
Proteasome
Factor Xa
|
Inflammation/Immunology
|
|
Gabexate mesylate (FOY) is is a competitive and non-antigenic synthetic inhibitor of trypsin-like serine proteinases. Gabexate mesylate inhibits human thrombin, urokinase, plasmin, and Factor Xa with Kis of 0.97, 1.3, 1.6, and 8.5 μM, respectively. Gabexate mesylate binds to human and bovine tryptase with Kis of 3.4 nM and 18 μM, respectively. Gabexate mesylate exerts an anticoagulant effect on the clotting activity of thrombin and has anti-inflammatory effect by viainhibition of NF-κB, proinflammatory cytokines, and nitric oxide. Gabexate mesylate is used for pancreatitis and disseminated intravascular coagulation [1] .
|
-
- HY-118652
-
|
ω-3 6-keto PGF2α
|
Prostaglandin Receptor
|
Metabolic Disease
|
|
Δ17-6-keto Prostaglandin F1α (Δ17-6-keto PGF1α) is a cyclooxygenase (COX) product of eicosapentaenoic acid (EPA) in various tissues such as seminal vesicles, lung, Polymorphonuclear leukocytes, and ocular tissues. Δ17-6-keto PGF1α and other 3-series COX products from EPA, such as PGF3α, PGE3, and thromboxane B3, may be involved in the reduced incidence of glaucoma in patients on a marine-rich (EPA-rich) diet.
|
-
- HY-135552
-
-
- HY-24312
-
|
|
Biochemical Assay Reagents
|
Others
|
|
AD-mix-α is a mixture of organic compounds, commonly used to distinguish and identify asymmetric carbon atoms in chiral compounds. It consists of compounds containing catalytically active metals and chiral ligands. AD-mix-α is widely used in various organic synthesis reactions, such as hydrogenation, addition, and carbonylation reactions, to increase yield and reduce the formation of side reaction products. Although it has no direct application in the medical field, it plays an important role in the pharmaceutical industry and chemical research.
|
-
- HY-N6962
-
|
|
TRP Channel
COX
Bacterial
|
Infection
Neurological Disease
Metabolic Disease
|
|
α-Spinasterol is an orally taken antagonist of transient receptor potential vanilloid 1 ( TRPV1), and it's also an inhibitor of COX-1 and COX-2, with IC50 values of 16.17 μM and 7.76 μM, respectively. α-Spinasterol exhibits antibacterial, anti-inflammatory, antidepressant, and antioxidant effects, has the ability to cross the blood-brain barrier, and can improve diabetes in mice [1] .
|
-
- HY-103511
-
|
|
GABA Receptor
|
Neurological Disease
|
|
TCS1105 is a benzodiazepine ligand with agonist for α2-subunit containing GABAA receptors and antagonist for α1-subunit containing GABAA receptors. TCS1105 reduces anxiety-like behavior in mice. TCS1105 enhances offensive behavior and social dominance. TCS1105 blocks Sema3A induced AGC (axonal growth cones) collapse in a concentration-dependent fashion [1] .
|
-
- HY-16560S
-
|
Campathecin-d5; (S)-(+)-Camptothecin-d5; CPT-d5
|
Isotope-Labeled Compounds
Topoisomerase
ADC Cytotoxin
MicroRNA
Influenza Virus
Apoptosis
Fungal
Antibiotic
|
Infection
Cancer
|
|
Camptothecin-d5 is the deuterium labeled Camptothecin. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM [1]. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells .
|
-
- HY-16708A
-
|
|
AMPK
|
Metabolic Disease
|
|
ZLN024 hydrochloride is an AMPK allosteric activator. ZLN024 directly activates recombinant AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1 and AMPK α2β2γ1 heterotrimer with EC50s of 0.42 µM, 0.95 µM, 1.1 µM and 0.13 µM, respectively.
|
-
- HY-16708
-
|
|
AMPK
|
Metabolic Disease
|
|
ZLN024 is an AMPK allosteric activator. ZLN024 directly activates recombinant AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1 and AMPK α2β2γ1 heterotrimer with EC50s of 0.42 µM, 0.95 µM, 1.1 µM and 0.13 µM, respectively.
|
-
- HY-W039937
-
-
- HY-128428
-
|
15(S)-15-Methyl Prostaglandin F2α; 15-Methyl-PGF2α
|
Prostaglandin Receptor
|
Endocrinology
|
|
Carboprost (15(S)-15-Methyl Prostaglandin F2α) is a metabolically stable synthetic analog of prostaglandin F2α. Carboprost stimulates uterine contractions and induces abortion. Carboprost is used for postpartum hemorrhage due to uterine atony and for the termination of pregnancy in the second trimester [1] .
|
-
- HY-P990126
-
|
|
Integrin
|
Others
|
|
Anti-Rat CD8α Antibody (OX-8) is a mouse-derived IgG1, κ type antibody inhibitor, targeting to rat CD8α.
|
-
- HY-113263S1
-
-
- HY-19012
-
|
|
Adrenergic Receptor
|
Cardiovascular Disease
|
|
N-1518 is an α and β adrenergic receptor blocker that has competitive antagonism against β1 and α1 receptors, but does not show selectivity for β1 receptors, but shows about 20-fold selectivity for α1 receptors. N-1518 has vasodilatory effects and can be used in the research field of hypertension treatment [1].
|
-
- HY-43747
-
|
Acetobromo-α-D-glucose, contains 1% CaCO3 as stabilizer; Acetobromo-Alpha-D-glucose, contains 1% CaCO3 as stabilizer
|
Biochemical Assay Reagents
Drug Intermediate
|
Others
|
|
α-Acetobromoglucose, contains 1% CaCO3 as stabilizer (Acetobromo-α-D-glucose, contains 1% CaCO3 as stabilizer) is a glycosyl donor that can be used for the synthesis of other active compounds [1] .
|
-
- HY-134670S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
α-Hydroxy Metoprolol-d5 (Mixture of Diastereomers) is the deuterium labeled α-Hydroxy Metoprolol Mixture of Diastereomers [1].
|
-
- HY-171289
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Neu5Acα2-6GalNAcα1-4GlcNac is the derivative of Neu5Acα2-6GalNAcα. Neu5Acα2-6GalNAcα can be used for synthesis of glycopolymer [1].
|
-
- HY-N6821R
-
|
|
Drug Derivative
Reference Standards
|
Cancer
|
|
2-O-α-D-Glucopyranosyl-L-ascorbic Acid (Standard) is the analytical standard of 2-O-α-D-Glucopyranosyl-L-ascorbic Acid. This product is intended for research and analytical applications. 2-O-α-D-Glucopyranosyl-L-ascorbic Acid is a glucoside derivative of ascorbic acid, shows anti-cancer activity after enzymatic hydrolysis to ascorbic acid [1].
|
-
- HY-E70299
-
|
ST3GAL5
|
TGF-beta/Smad
|
Cancer
|
|
ST3 β-Gal α-2,3-Sialyltransferase 5 (ST3GAL5) is a glycosphingolipid (GSL) biosynthetic enzyme that can inhibit TGF-β-induced epithelial-mesenchymal transition (EMT), invasion, and metastasis both in vivo and in vitro. ST3 β-Gal α-2,3-Sialyltransferase 5 can be used in cancer research [1].
|
-
- HY-139124
-
|
15(R)-Carboprost; 15(R)-15-methyl PGF2α
|
Prostaglandin Receptor
|
Metabolic Disease
|
|
15(R)-15-Methyl Prostaglandin F2α (15(R)-Carboprost; 15(R)-15-methyl PGF2α) is a metabolically stable analog of PGF2α. 15(R)-15-Methyl Prostaglandin F2α is an inactive, prodrug PGF agonist designed for activation by gastric acid after oral administration. Acid-catalyzed epimerization of 15(R)-15-Methyl Prostaglandin F2α converts it into the active 15(S)-isomer. The 15(S)-isomer induces luteolysis when injected in rhesus monkeys at a dose of about 12 mg/animal, while the 15(R)-isomer does not.
|
-
- HY-170460
-
-
- HY-W014292S
-
-
- HY-137611A
-
|
|
DNA/RNA Synthesis
|
Cancer
|
|
α,β-MTDP trisodium, a thymidylate analog, is a thymidine kinase inhibitor with a Ki of 23 µM [1].
|
-
- HY-Y0549
-
|
Diphenylmethane-α-carboxylic Acid
|
Biochemical Assay Reagents
|
Others
|
|
Diphenylacetic acid (Diphenylmethane-α-carboxylic Acid) is a biochemical reagent that can be used as a biological material or organic compound for life science related research [1].
|
-
- HY-N1919
-
|
Raubasine
|
Adrenergic Receptor
Cholinesterase (ChE)
|
Neurological Disease
Endocrinology
|
|
Ajmalicine (Raubasine) is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine is an reversible but non-competitive nicotine receptor full inhibitor, with an IC50 of 72.3 μM. Ajmalicine also can be used as anti-hypertensive, and serpentine, with sedative activity [1] .
|
-
- HY-19036
-
|
|
Adrenergic Receptor
|
Neurological Disease
|
|
SDZ NVI 085 is a compound with CNS stimulatory effects, primarily through the α1-adrenoceptor subtype, with anti-cataplexy and anti-stroke activities. SDZ NVI 085 also has a significant alertness effect and can be used to study other types of excessive sleepiness [1].
|
-
- HY-N1919A
-
|
Raubasine hydrochloride
|
Adrenergic Receptor
Cholinesterase (ChE)
|
Neurological Disease
Endocrinology
|
|
Ajmalicine (Raubasine) hydrochloride is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine hydrochloride is an reversible but non-competitive nicotine receptor full inhibitor, with an IC50 of 72.3 μM. Ajmalicine hydrochloride also can be used as anti-hypertensive, and serpentine, with sedative activity [1] .
|
-
- HY-19037
-
-
- HY-B0371A
-
|
|
Adrenergic Receptor
|
Cardiovascular Disease
Metabolic Disease
Endocrinology
|
|
Terazosin hydrochloride dihydrate is a quinazoline derivative and a competitive and orally active α1-adrenoceptor antagonist. Terazosin hydrochloride dihydrate works by relaxing blood vessels and the opening of the bladder. Terazosin hydrochloride dihydrate has the potential for benign prostatic hyperplasia (BPH) and high blood pressure treatment [1] .
|
-
- HY-167925S
-
-
- HY-165673S
-
|
9α-Hexahydocaabiol-d9, 11α-Hexahydocaabiol-d9, 9α-HHC-d9, 9(S)-HHC-d9, 11α-HHC-d9, tas-(6aR,9S,10aR)-HHC-d9
|
Isotope-Labeled Compounds
|
Others
|
|
9(S)-Hexahydrocannabinol-d9 (9α-Hexahydocaabiol-d9, 11α-Hexahydocaabiol-d9, 9α-HHC-d9, 9(S)-HHC-d9, 11α-HHC-d9, tas-(6aR,9S,10aR)-HHC-d9) is deuterium labeled 9(S)-Hexahydrocannabinol [1].
|
-
- HY-19776
-
|
|
Phosphatase
|
Cancer
|
|
3α-Aminocholestane is a selective SH2 domain-containing inositol-5′-phosphatase 1 (SHIP1) inhibitor with an IC50 of ~2.5 μM.
|
-
- HY-W086896
-
-
- HY-137119A
-
|
|
Prostaglandin Receptor
|
Others
|
|
8,12-iso-iPF2α-VI is a F2-isoprostanes. 8,12-iso-iPF2α-VI is a sensitive and specific marker of in vivo lipid peroxidation. 8,12-iso-iPF2α-VI can be used as a biomarker of oxidative damage in alzheimer's disease [1].
|
-
- HY-100838
-
|
L-CCG III
|
EAAT
|
Neurological Disease
|
|
cis-α-(Carboxycyclopropyl)glycine (L-CCG III) is a potent, competitive glutamate uptake inhibitor. cis-α-(Carboxycyclopropyl)glycine is a substrate of glutamate transporters (GluT) (EC50: 13 μM, 2 μM for EAAT 1 and EAAT 2, respectively). cis-α-(Carboxycyclopropyl)glycine inhibits a Na +-dependent high-affinity L-glutamate uptake in glial plasmalemmal vesicles (GPV) and synaptosomes [1] .
|
-
- HY-P5881
-
|
|
PKC
|
Cardiovascular Disease
|
|
PKCα (C2-4) inhibitor peptide is a PKCα specific inhibitor peptide that blocks the inhibition of IKr by the α1A adrenoreceptor agonist A-61603 (HY-101366) [1].
|
-
- HY-N7178
-
|
|
Others
|
Others
|
|
Abieta-8,11,13-triene-7α,15,18-triol is an abietane diterpene. Abieta-8,11,13-triene-7α,15,18-triol can be isolated from the CHCl3 extract of the cones of Larix koempferi [1].
|
-
- HY-N15304
-
|
|
Others
|
Others
|
|
Ent-17α,18-dihydroxy-kauran-19-oic acid (81) is a natural compound that can be isolated from S. pubescens [1].
|
-
- HY-W330097
-
-
- HY-W154367
-
-
- HY-12710A
-
-
- HY-P1793A
-
|
|
Opioid Receptor
Biochemical Assay Reagents
|
Neurological Disease
Inflammation/Immunology
Cancer
|
|
α-Casein (90-95) TFA is a partial agonist of opioid receptors and a copper ion ligand, with opioid activity. α-Casein (90-95) TFA inhibits the secretion of β-hexosaminidase by rat peritoneal mast cells (PMC) with IC50= 0.1 μM. α-Casein (90-95) TFA inhibits the proliferation of prostate cancer cells LNCaP, DU145, and PC3 with IC50 of 0.94 nM, 137 nM, and 6.92 nM, respectively. α-Casein (90-95) TFA activates Gi-like proteins through a membrane-assisted, receptor-independent pathway, or reversibly binds to opioid receptors, inducing intracellular calcium release and conformational changes, and exerts the activity of promoting mast cell secretion and inhibiting tumor cell proliferation. α-Casein (90-95) TFA can be used in the study of the mechanisms of allergic diseases and prostate cancer [1] .
|
-
- HY-W014780
-
|
2-Benzylideneheptanal; α-Pentylcinnamaldehyde
|
CETP
|
Others
|
|
α-Amylcinnamaldehyde is a ligand for the Niemann-Pick type C2 (NPC2) protein of arthropod moths and may play a key role in the identification of moth volatiles. NPC2 is a key enzyme for cholesterol transport in the body [1].
|
-
- HY-P1314
-
-
- HY-D0981
-
|
Coumarin 151; AFC
|
Fluorescent Dye
|
Others
|
|
7-Amino-4-(trifluoromethyl)coumarin (Coumarin 151) is a fluorescent marker for the sensitive detection of proteinases. The excitation and emission wavelengths are 400 and 490 nm, respectively.
|
-
- HY-P2519A
-
-
- HY-N2990
-
|
3β,16α-Dihydroxylanosta-7,9(11),24-trien-21-oic acid
|
Others
|
Inflammation/Immunology
|
|
16α-Hydroxydehydrotrametenolic acid is a triterpene Acid in fermented mycelia of edible fungus Poria cocos [1].
|
-
- HY-128747
-
-
- HY-128747A
-
-
- HY-104004
-
|
Fmoc-Ser-(GalNAc(Ac)3-Alpha-D)-OH; Fmoc-Ser[GalNAc(Ac)3-α-D]-OH; Fmoc-Ser(Ac3AcNH-α-Gal)-OH
|
Amino Acid Derivatives
|
Cancer
|
|
Fmoc-Ser(O-α-D-GalNAc(OAc)3)-OH is a agent for cancer.
|
-
- HY-158826
-
|
RO 707179
|
HIF/HIF Prolyl-Hydroxylase
|
Cancer
|
|
EZN-2968 is an antisense oligonucleotide that specifically binds and inhibits the expression of HIF-1α mRNA. EZN-2968, inhibits tumor cell growth.
|
-
- HY-W023757
-
|
|
Drug Intermediate
|
Others
|
|
N-Hydroxyisonicotinamidine is an amidoxime-based collector. N-Hydroxyisonicotinamidine can be used in the synthesis of substituted α-1,2,4-oxadiazolo esters [1].
|
-
- HY-158826A
-
|
|
HIF/HIF Prolyl-Hydroxylase
|
Cancer
|
|
EZN-2968 sodium is an antisense oligonucleotide that specifically binds and inhibits the expression of HIF-1α mRNA. EZN-2968 sodium, inhibits tumor cell growth.
|
-
- HY-176011
-
|
17-Phenyl trinor PGF2α glycinamide methyl ester
|
Prostaglandin Receptor
|
Endocrinology
|
|
17-Phenyl trinor prostaglandin F2α glycinamide methyl ester is a derivative of Bimatoprost (HY-B0191) and a prostaglandin analog. 17-Phenyl trinor prostaglandin F2α glycinamide methyl ester is a human prostaglandin FP receptor agonist. 17-Phenyl trinor prostaglandin F2α glycinamide methyl ester has an ocular hypotensive effect and can be used in the study of ocular hypertension and glaucoma [1].
|
-
- HY-B0891R
-
-
- HY-W654080
-
|
α,α'-Bis(4-hydroxyphenyl)-1,4-diisopropylbenzene-13C4
|
Isotope-Labeled Compounds
|
Others
|
|
Bisphenol P- 13C4 is 13C labeled α,α'-Bis(4-hydroxyphenyl)-1,4-diisopropylbenzene [1].
|
-
- HY-W705371
-
|
|
Drug Metabolite
GABA Receptor
|
Others
|
|
α-Hydroxy etizolam is the primary metabolite of Etizolam, possessing nearly identical pharmacological potency and high affinity for benzodiazepine receptors as Etizolam [1].
|
-
- HY-128417
-
-
- HY-121481
-
|
10α-Cucurbitadienol
|
Others
|
Inflammation/Immunology
|
|
Cucurbitadienol (10α-Cucurbitadienol) is a natural product that can be found in the seeds of Trichosanthes kirilowii. Cucurbitadienol exhibits anti-inflammatory effect [1].
|
-
- HY-B0522A
-
|
D-(-)-α-Aminobenzylpenicillin sodium salt
|
Bacterial
Antibiotic
|
Infection
|
|
Ampicillin sodium (D-(-)-α-Aminobenzylpenicillin sodium salt) is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria [1].
|
-
- HY-N11189
-
-
- HY-N7858
-
|
α-Parinaric acid
|
Others
|
Cancer
|
|
cis-Parinaric acid (α-Parinaric acid) is a fatty acid that can be isolated from Impatiens edgeworthii seed oil [1].
|
-
- HY-N10601
-
|
Neoilexonol
|
Others
|
Others
|
|
11-Oxo-α-amyrin (Neoilexonol) is a triterpenoid that can be isolated from Leonurus japonicus (Lamiaceae) [1].
|
-
- HY-W739861
-
|
1'-Hydroxytriazolam
|
Endogenous Metabolite
|
Others
|
|
α-Hydroxytriazolam (1'-Hydroxytriazolam) is a major metabolite of ranitidine (HY-B0693) [1].
|
-
- HY-N10794
-
|
|
Others
|
Cancer
|
|
18β-Hydroxy-3-epi-α-yohimbine is a yohimbine derivative. 18β-Hydroxy-3-epi-α-yohimbine is a nature product that can be found in Rauvolfia vomitoria [1].
|
-
- HY-N11901
-
|
|
Others
|
Others
|
|
Quercetin-3-O-[(6-caffeoyl)-β-glucopyranosyl (1→3) α-rhamnopyranoside]-7-O-α-rhamnopyranoside can be isolated from the aerial parts of the fern Ophioglossum vulgatum L and has wound healing activity [1].
|
-
![Quercetin-3-O-[(6-caffeoyl)-β-glucopyranosyl (1→3) α-rhamnopyranoside]-7-O-α-rhamnopyranoside](//file.medchemexpress.com/product_pic/hy-n11901.gif)
- HY-W291944
-
-
- HY-121783
-
|
|
Adrenergic Receptor
|
Others
|
|
BE2254 is a compound with antipyretic and metabolic activity, which has the activity of regulating the febrile response and metabolism. BE2254 can reduce the metabolic and febrile activity induced by lipopolysaccharide in febrile rabbits, suggesting that it may regulate body temperature by acting on the α1-adrenergic receptor mechanism.
|
-
- HY-P1860A
-
|
|
TNF Receptor
NF-κB
Apoptosis
|
Inflammation/Immunology
|
|
TNF-α (31-45), human TFA is a potent NF-kB pathway activator. TNF-αis a proinflammatory cytokine that induces necrosis or apoptosis. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis [1] .
|
-
- HY-114362
-
|
TPGS-750-M
|
Biochemical Assay Reagents
|
Others
|
|
DL-alpha-Tocopherol methoxypolyethylene glycol succinate (TPGS-750-M) is an amphiphile, acts as a surfactant. DL-alpha-Tocopherol methoxypolyethylene glycol succinate has a positive effect on Suzuki-Miyaura cross coupling. DL-alpha-Tocopherol methoxypolyethylene glycol succinate increases the styrene titer. DL-alpha-Tocopherol methoxypolyethylene glycol succinate is used in the stability test of NPYM-modified drugs in biological fluids [1] .
|
-
- HY-W010789
-
-
- HY-141126
-
|
|
Biochemical Assay Reagents
|
Cancer
|
|
Azido-PEG4-alpha-D-mannose is a PEG linker that combines an azide group with an alpha-D-mannose moiety. Azido-PEG4-alpha-D-mannose is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Azido-PEG4-alpha-D-mannose has the targeting property of mannose, which can accurately deliver drugs to specific cells or tissues to improve the therapeutic effect of drugs [1].
|
-
- HY-N10091
-
|
|
Apoptosis
|
Others
|
|
2,3-Dihydro-3α-methoxynimbolide is a limonoid compound isolated from the extracts of bark, leaves, roots, and seeds of Azadirachta indica A. Juss. var. siamensis Valeton. 2,3-Dihydro-3α-methoxynimbolide exhibits potent cyto-toxicities against one or more cell lines. 2,3-Dihydro-3α-methoxynimbolide activates caspases-3, -8, and -9, while increases the ratio of Bax/Bcl-2. 2,3-Dihydro-3α-methoxynimbolide induces apoptosis via both mitochondrial and death receptor pathways in AZ521 [1].
|
-
- HY-W342193
-
-
- HY-15911
-
|
2-Chloro-4-nitrophenyl α-L-fucopyranoside
|
Biochemical Assay Reagents
|
Others
|
|
CNP-AFU (2-Chloro-4-nitrophenyl α-L-fucopyranoside) is a substrate for alpha-L-fucosidase(AFU).
|
-
- HY-N9091
-
|
|
Others
|
Others
|
|
9α,11-Dihydroxydrim-7-en-6-one is a Sesquiterpenoids product that can be isolated from the leaves and the bark of Drimys winteri [1].
|
-
- HY-117061
-
|
|
Prostaglandin Receptor
|
Endocrinology
|
|
Prostaglandin F2α alcohol methyl ether is an alcohol methyl ether G protein-coupled receptor. Prostaglandin F2α is also a luteinizing hormone in sheep and may be a nociceptive mediator in the spinal cord [1] .
|
-
- HY-10002A
-
|
1α,25-Dihydroxy-3-epi-vitamin-D3
|
VD/VDR
|
Others
|
|
(1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3) is a natural metabolite of 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3). (1S)-Calcitriol exhibits potent vitamin D receptor (VDR)-mediated actions such as inhibition of keratinocyte growth or suppression of parathyroid hormone secretion [1].
|
-
- HY-N1936
-
|
α-Spinasterol glucoside
|
Others
|
Inflammation/Immunology
|
|
α-Spinasterol-3-O-β-D-glucoside is a sterol glucoside that can be isolated from the seeds of Momordica cochinchinensis [1].
|
-
- HY-138071
-
|
8αTGH
|
STAT
Pyroptosis
Apoptosis
Reactive Oxygen Species (ROS)
c-Myc
Bcl-2 Family
TrxR
|
Cancer
|
|
8α-Tigloyloxyhirsutinolide 13-O-acetate (8αTGH) is a potent and orally active STAT3 inhibitor. 8α-Tigloyloxyhirsutinolide 13-O-acetate induces early oxidative stress and pyroptosis, and late DNA damage, cell cycle arrest, apoptosis in the TNBC cells. 8α-Tigloyloxyhirsutinolide 13-O-acetate suppresses tumor cell growth in vitro and tumor growth in vivo [1] .
|
-
- HY-131335
-
|
|
p38 MAPK
|
Inflammation/Immunology
|
|
p38α inhibitor 2 is a highly potent and selective p38α MAPK inhibitor, with a pIC50 of 9.6. p38α inhibitor 2 inhibits the hERG ion channel (IC50=27 μM) and shows a promising selectivity profile when tested in a panel of 51 other protein kinases (<30% inhibition at 10 μM concentration) and a panel of 141 other biological targets [1].
|
-
- HY-N0181A
-
|
9β,10α-Ergosterol
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Lumisterol (9β,10α-Ergosterol), a steroid compound, is the (9β,10α)-stereoisomer of Ergosterol (HY-N0181). Lumisterol is a photoprotective agent against UVB-induced DNA damage and anti-proliferative activities [1].
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-
- HY-155113
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PROTACs
HSP
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Cancer
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PROTAC Hsp90α degrader 1 (Compound X10g) is a selective PROTAC Hsp90α degrader. PROTAC Hsp90α degrader 1 can be used for breast cancer research. PROTAC Hsp90α degrader 1 inhibits the proliferation of MDA-MB-231, MDA-MB-468, MCF-7, MX-1 cells with IC50s of 51.48 μM, 16.46 μM, 8.93 μM, 11.95 μM respectively [1].
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- HY-N8550
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α-Cortolone
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Glucocorticoid Receptor
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Endocrinology
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Cortolone (α-Cortolone) is a metabolite of the glucocorticoid cortisol (Hydrocortisone (HY-N0583)). Hydrocortisone is a steroid hormone or glucocorticoid secreted by the adrenal cortex.
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- HY-114998
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2-Acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy-α-D-glucopyranose
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Biochemical Assay Reagents
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Others
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α-D-Glucosamine pentaacetate (2-Acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy-α-D-glucopyranose) can be used in glycobiology research.
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- HY-111052
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GABA Receptor
Cytochrome P450
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Neurological Disease
Inflammation/Immunology
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AZD7325 is a potent and orally active partial selective PAM of GABAAα2 and Aα3 receptor (Ki=0.3 and 1.3 nM, respectively), and has less antagonistic efficacy at the Aα1 and Aα5 receptor subtypes [1] . AZD7325 is a moderate CYP1A2 and a potent CYP3A4 inducer in vitro . AZD7325 has the potential for the investigation of anxiety and dravet syndrome . PAM: positive allosteric modulator.
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- HY-P1071A
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Calcitonin gene-related peptide TFA
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CGRP Receptor
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Cardiovascular Disease
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α-CGRP(human) (TFA) is a regulatory neuropeptide of 37 amino acids. α-CGRP(human) (TFA) is widely distributed in the central and peripheral nervous system. α-CGRP(human) (TFA) is a potent vasodilator and has inotropic and chronotropic effects [1].
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- HY-117580S
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OH-PRED-d3
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Isotope-Labeled Compounds
Drug Metabolite
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Inflammation/Immunology
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16α-Hydroxyprednisolone-d3 is the deuterium labeled 16α-Hydroxyprednisolone. 16α-Hydroxyprednisolone is a stereoselective metabolite of the 22(R) epimer of the glucocorticoid Budesonide (HY-13580). 16α-Hydroxyprednisolone formation is catalyzed by isoenzymes within the cytochrome P450 3A (CYP3A) subfamily. 16α-Hydroxyprednisolone formation can be inhibited by antibodies targeting the CYP3A subfamily [1] .
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- HY-N1812
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Others
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Others
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3α-Cinnamoyloxypterokaurene L3 is a Diterpenoids product that can be isolated from the herbs of Wedelia trilobata [1].
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- HY-N3699
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ent-15α-Hydroxykaurenoic acid
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Others
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Others
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Deacetylxylopic acid (ent-15α-Hydroxykaurenoic acid) is a Diterpene product that can be isolated from Blumea eriantha [1].
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- HY-N1811
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Others
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Others
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3α-Angeloyloxypterokaurene L3 is a Diterpenoids product that can be isolated from the herbs of Wedelia trilobata [1].
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- HY-N4215
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Others
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Inflammation/Immunology
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11(α)-Methoxysaikosaponin F is a triterpenoid saponin isolated from Bupleurum marginatum Wall.ex DC(ZYCH) which is a promising therapeutic for liver fibrosis. 11(α)-Methoxysaikosaponin F has an IC50 of 387.7 nM with viability of hepatic stellate cells-T6 (HSCs-T6). Triterpenoid saponins have numerous targets, important network positions, and strong inhibitory activity [1].
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- HY-P9911A
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Integrin
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Inflammation/Immunology
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Vedolizumab (anti-α4β7-integrin) is a humanized IgG1 monoclonal antibody that targets the α4β7 integrin for the treatment of ulcerative colitis and Crohn's disease [1] .
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- HY-123044
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- HY-P1090
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Cannabinoid Receptor
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Neurological Disease
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Hemopressin(rat) is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin(rat) is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin(rat) exerts antinociceptive action in inflammatory pain models [1] .
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- HY-P1091A
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Cannabinoid Receptor
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Neurological Disease
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Hemopressin TFA is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin TFA is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin TFA exerts antinociceptive action in inflammatory pain models [1] .
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- HY-121186R
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Reference Standards
Adrenergic Receptor
Calcium Channel
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Neurological Disease
Metabolic Disease
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Bevantolol (hydrochloride) (Standard) is the analytical standard of Bevantolol (hydrochloride). This product is intended for research and analytical applications. Bevantolol hydrochloride is a selective β1 and α1-adrenergic receptor antagonist with pKi values of 7.83, 6.9 in rat cerebral cortex, respectively. Bevantolol hydrochloride is a potent Ca 2+ antagonist [1] .
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- HY-114794R
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ST 1059 (Standard)
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Reference Standards
Adrenergic Receptor
Drug Metabolite
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Cardiovascular Disease
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Desglymidodrine (Standard) is the analytical standard of Desglymidodrine. This product is intended for research and analytical applications. Desglymidodrine (ST 1059), the active metabolite of Midodrine (HY-12749), is a selective α1-adrenoceptor agonist. Desglymidodrine is an effective arterial and venous vasoconstrictor and can be used to regulate blood pressure [1] .
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- HY-W802699
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Biochemical Assay Reagents
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Others
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α-Ketoglutaric acid disodium dihydrate, an important dicarboxylic acid, is an intermediate in the tricarboxylic acid cycle (TCC) and amino acid metabolism. α-Ketoglutaric acid disodium dihydrate can be used as building block chemical for the chemical synthesis of heterocycles, dietary supplement, component of infusion solutions and wound healing compounds, or as main component of new elastomers with a wide range of interesting mechanical and chemical properties [1].
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- HY-P99246
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- HY-N2024
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- HY-120823
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- HY-128041
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Hydroxyfarnesyl phosphate
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Farnesyl Transferase
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Others
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α-hydroxy Farnesyl phosphonic acid is a nonhydrolyzable analog of farnesyl pyrophosphate which acts as a competitive inhibitor of farnesyl transferase (FTase). At concentrations greater than 1 μM, α-hydroxy farnesyl phosphonic acid inhibits the processing of Ras in Ha-ras-transformed NIH3T3 cells.
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- HY-114810
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Prostaglandin Receptor
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Endocrinology
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Prostaglandin F2α serinol amide is a serinolamide G protein-coupled receptor that increases calcium levels in human non-small cell lung cancer cells. Prostaglandin F2α is also a luteinizing hormone in sheep and may be a nociceptive mediator in the spinal cord [1] .
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- HY-P1314A
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- HY-N1202
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Sitostane-3β,5α,6β-triol
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Others
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Others
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Sitostanetriol (Sitostane-3β,5α,6β-triol) is a steroid isolated from Casearia membranacea (Flacourtiaceae) [1].
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- HY-W778920
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Dihydrocholesterol7; 5α-Cholestanol7; NSC 181887
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Isotope-Labeled Compounds
Endogenous Metabolite
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Others
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5α-Cholestan-3β-ol-d7 (Dihydrocholesterol-d7; 5α-Cholestanol-d7; NSC 18188-d7) is the deuterium labeled 5α-Cholestan-3β-ol (HY-107819). 5α-Cholestan-3β-ol is a derivitized steroid compound.
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- HY-N13578
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Others
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Others
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Soyasapogenol A 21-O-α-L-rhamnopyranoside is a natural product [1].
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- HY-121910
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- HY-148325
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nAChR
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Neurological Disease
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α7 Nicotinic receptor agonist-1 (Preparation 5) is an α7 nAChR agonist. α7 Nicotinic receptor agonist-1 can be used in studies of psychiatric disorders (such as schizophrenia, manic or hypomanic depression and anxiety disorders) and intellectual disorders (such as alzheimer's disease, learning deficits, cognitive deficits, attention deficits, memory loss, lewy body dementia and attention deficit hyperactivity disorder) [1].
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- HY-N0988
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Others
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Cancer
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1β,4β,7α-Trihydroxyeudesmane (compound 4) is a nature product that could be isolated from the rhizomes of Homalomena occulta. 1β,4β,7α-Trihydroxyeudesmane has antiproliferative active. 1β,4β,7α-Trihydroxyeudesmane can be used in research of cancer [1].
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- HY-N15092
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Meilingmycin A
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Antibiotic
Parasite
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Infection
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Milbemycin α11 (Meilingmycin A) is an antibiotic and has the effect of killing nematodes and mites [1].
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- HY-170027
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HIF/HIF Prolyl-Hydroxylase
AMPK
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Cancer
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LW1564 is an inhibitor for HIF-1α with an IC50 of 1.2 µM in HepG2. LW1564 inhibits mitochondrial respiration, reduces ATP production, stimulates HIF-1α degradation, and inhibits proliferation of various cancer cells with GI50 of 0.4-4.6 μM. LW1564 activates AMPK signaling pathway and inhibits lipid synthesis. LW1564 exhibits antitumor in HepG2 xenograft mouse model [1].
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- HY-N10527
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Globoisotetraose
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Others
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Others
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Isoglobotetraose (Globoisotetraose) is the oligosaccharide moiety of human glycosphingolipids. Synthesis process: globotetraose (GalNAcβ1→3Galα1→4Galβ1→4Glc) and isoglobotetraose (GalNAcβ1→3Galα1→3Galβ1→4Glc) [1].
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- HY-16560R
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Campathecin (Standard); (S)-(+)-Camptothecin (Standard); CPT (Standard)
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Reference Standards
Topoisomerase
ADC Cytotoxin
MicroRNA
Influenza Virus
Apoptosis
Fungal
Antibiotic
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Infection
Cancer
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Camptothecin (Standard) (Campathecin (Standard)) is the analytical standard of Camptothecin (HY-16560). This product is intended for research and analytical applications. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells.
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- HY-P2857A
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Others
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Others
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Glucoamylase, Rhizopus sp. hydrolyzes α-1,4 and α-1,6 glucosidic bonds in starch and similar substrates, and releases β-glucose molecules primarily from the non-reducing end. Glucoamylase, Rhizopus sp. participates in glycogen metabolism, and is related to glycogen storage disease type II. Glucoamylase, Rhizopus sp. converses starch to glucose, which can be used in industrial production of high fructose syrup, alcohol, and other fermented products [1].
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- HY-19269
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Elastase
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Inflammation/Immunology
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FK706 is a potent, slow-binding and competitive inhibitor of human neutrophil elastase with an IC50 of 83 nM and a Ki of 4.2 nM. FK706 also inhibits mouse neutrophil elastase and porcine pancreatic elastase with IC50s of 22 nM and 100 nM, respectively, and has no inhibitory activity against other serine proteinases such as human pancreatic trypsin, human pancreatic α-chymotrypsin and human leukocyte cathepsin G. FK706 has anti-inflammatory effect [1] .
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- HY-138688
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CDC
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Lipoxygenase
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Metabolic Disease
Cancer
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Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC) is a potent 12/15-Lipoxygenases (LO) inhibitor. Cinnamyl-3,4-dihydroxy-α-cyanocinnamate has the potential for the research of type 1 diabetes mellitus [1].
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- HY-N1014
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Others
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Others
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11α,12β-Di-O-acetyltenacigenin B is a polyoxypregnane compound isolated from the CHCl(3)-soluble fraction of the ethanolic extract of the stem of Marsdenia tenacissima [1].
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- HY-134440A
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![(αR)-α-[[(1,1-Dimethylethoxy)carbonyl]amino]benzeneacetic acid](http://file.medchemexpress.com/product_pic/hy-34663.gif)
![A2[3]G1F1(α-1-3) glycan](http://file.medchemexpress.com/product_pic/hy-158458.gif)
![Lactalbumin B (50-53) Alpha [Lactorphin Alpha], bovine](http://file.medchemexpress.com/product_pic/hy-p3976.gif)
![Kaempferol-3-O-[(6-caffeoyl)-β-glucopyranosyl (1→3) α-rhamnopyranoside]-7-O-α-rhamnopyranoside](http://file.medchemexpress.com/product_pic/hy-n11910.gif)
![Quercetin-3-O-[(6-caffeoyl)-β-glucopyranosyl (1→3) α-rhamnopyranoside]-7-O-α-rhamnopyranoside](http://file.medchemexpress.com/product_pic/hy-n11901.gif)
