Search Result

Targets Recommended:	Phosphodiesterase (PDE) EAAT2 Fatty Acid Synthase (FASN)

Results for "Amino acids with pde Inhibitors" in MCE Product Catalog:

By Targets:	EAAT2 (2) Fatty Acid Synthase (FASN) (1) Phosphodiesterase (PDE) (121) 5-HT Receptor (4) AChE (2) Acyltransferase (2) ADC Cytotoxin (3) ADC Linker (30) Adenosine Deaminase (1) Adenosine Receptor (1) Adrenergic Receptor (1) Akt (1) Amyloid-β (9) Androgen Receptor (1) Angiotensin Receptor (2) Antibiotic (10) Antifolate (1) Apoptosis (18) Aryl Hydrocarbon Receptor (2) ATP Citrate Lyase (1) Autophagy (13) Bacterial (30) Bcr-Abl (1) Beta-secretase (1) Bradykinin Receptor (4) Btk (1) c-Met/HGFR (1) Calcium Channel (3) CaMK (1) Cannabinoid Receptor (1) Casein Kinase (1) CCR (1) CGRP Receptor (5) Chloride Channel (1) Cholecystokinin Receptor (4) COMT (1) COX (1) CRFR (2) CXCR (1) Cytochrome P450 (3) Deubiquitinase (1) DNA Methyltransferase (1) DNA/RNA Synthesis (3) Dopamine Receptor (3) Drug Metabolite (1) DYRK (2) EGFR (1) Endogenous Metabolite (135) Endothelin Receptor (3) Ephrin Receptor (1) Epoxide Hydrolase (1) ERK (2) FAAH (1) Factor Xa (1) Ferroptosis (3) FLAP (1) Fungal (1) FXR (1) GABA Receptor (3) Gap Junction Protein (3) GHSR (2) Glucagon Receptor (5) GLUT (1) GSK-3 (2) Guanylate Cyclase (2) Gutathione S-transferase (1) HDAC (1) HIF/HIF Prolyl-Hydroxylase (4) Histamine Receptor (1) Histone Demethylase (2) Histone Methyltransferase (1) HIV (4) HSP (1) iGluR (11) IKK (1) Influenza Virus (4) Integrin (1) JAK (1) JNK (1) Leukotriene Receptor (1) Ligand for E3 Ligase (1) LXR (1) mAChR (3) MCHR1 (GPR24) (2) MDM-2/p53 (1) Melanocortin Receptor (1) mGluR (3) Microtubule/Tubulin (1) Mitochondrial Metabolism (2) MMP (1) mTOR (1) Na+/K+ ATPase (4) nAChR (5) Neuropeptide Y Receptor (6) NF-κB (4) NKCC (1) NO Synthase (4) Nucleoside Antimetabolite/Analog (1) Opioid Receptor (2) Orexin Receptor (OX Receptor) (4) P-glycoprotein (1) P2Y Receptor (2) p38 MAPK (2) Parasite (4) PDHK (1) Phosphatase (2) PI3K (1) PKA (4) PKC (4) Potassium Channel (8) PPAR (2) Prostaglandin Receptor (1) PROTAC Linker (92) Proteasome (1) Proton Pump (3) RAR/RXR (1) Reactive Oxygen Species (4) Reverse Transcriptase (1) Ribosomal S6 Kinase (RSK) (1) ROR (2) RSV (1) SARS-CoV (2) Smo (1) Sodium Channel (2) Somatostatin Receptor (2) STAT (1) Survivin (1) Thrombin (3) Thyroid Hormone Receptor (2) TNF Receptor (3) Topoisomerase (1) TRP Channel (2) Tyrosinase (1) Urotensin Receptor (2) Virus Protease (2) Xanthine Oxidase (1)
By Research Areas:	Cancer (241) Cardiovascular Disease (96) Endocrinology (36) Infection (61) Inflammation/Immunology (118) Metabolic Disease (147) Neurological Disease (146)

By Targets:

EAAT2 (2)

Fatty Acid Synthase (FASN) (1)

Phosphodiesterase (PDE) (121)

5-HT Receptor (4)

AChE (2)

Acyltransferase (2)

ADC Cytotoxin (3)

ADC Linker (30)

Adenosine Deaminase (1)

Adenosine Receptor (1)

Adrenergic Receptor (1)

Akt (1)

Amyloid-β (9)

Androgen Receptor (1)

Angiotensin Receptor (2)

Antibiotic (10)

Antifolate (1)

Apoptosis (18)

Aryl Hydrocarbon Receptor (2)

ATP Citrate Lyase (1)

Autophagy (13)

Bacterial (30)

Bcr-Abl (1)

Beta-secretase (1)

Bradykinin Receptor (4)

Btk (1)

c-Met/HGFR (1)

Calcium Channel (3)

CaMK (1)

Cannabinoid Receptor (1)

Casein Kinase (1)

CCR (1)

CGRP Receptor (5)

Chloride Channel (1)

Cholecystokinin Receptor (4)

COMT (1)

COX (1)

CRFR (2)

CXCR (1)

Cytochrome P450 (3)

Deubiquitinase (1)

DNA Methyltransferase (1)

DNA/RNA Synthesis (3)

Dopamine Receptor (3)

Drug Metabolite (1)

DYRK (2)

EGFR (1)

Endogenous Metabolite (135)

Endothelin Receptor (3)

Ephrin Receptor (1)

Epoxide Hydrolase (1)

ERK (2)

FAAH (1)

Factor Xa (1)

Ferroptosis (3)

FLAP (1)

Fungal (1)

FXR (1)

GABA Receptor (3)

Gap Junction Protein (3)

GHSR (2)

Glucagon Receptor (5)

GLUT (1)

GSK-3 (2)

Guanylate Cyclase (2)

Gutathione S-transferase (1)

HDAC (1)

HIF/HIF Prolyl-Hydroxylase (4)

Histamine Receptor (1)

Histone Demethylase (2)

Histone Methyltransferase (1)

HIV (4)

HSP (1)

iGluR (11)

IKK (1)

Influenza Virus (4)

Integrin (1)

JAK (1)

JNK (1)

Leukotriene Receptor (1)

Ligand for E3 Ligase (1)

LXR (1)

mAChR (3)

MCHR1 (GPR24) (2)

MDM-2/p53 (1)

Melanocortin Receptor (1)

mGluR (3)

Microtubule/Tubulin (1)

Mitochondrial Metabolism (2)

MMP (1)

mTOR (1)

Na+/K+ ATPase (4)

nAChR (5)

Neuropeptide Y Receptor (6)

NF-κB (4)

NKCC (1)

NO Synthase (4)

Nucleoside Antimetabolite/Analog (1)

Opioid Receptor (2)

Orexin Receptor (OX Receptor) (4)

P-glycoprotein (1)

P2Y Receptor (2)

p38 MAPK (2)

Parasite (4)

PDHK (1)

Phosphatase (2)

PI3K (1)

PKA (4)

PKC (4)

Potassium Channel (8)

PPAR (2)

Prostaglandin Receptor (1)

PROTAC Linker (92)

Proteasome (1)

Proton Pump (3)

RAR/RXR (1)

Reactive Oxygen Species (4)

Reverse Transcriptase (1)

Ribosomal S6 Kinase (RSK) (1)

ROR (2)

RSV (1)

SARS-CoV (2)

Smo (1)

Sodium Channel (2)

Somatostatin Receptor (2)

STAT (1)

Survivin (1)

Thrombin (3)

Thyroid Hormone Receptor (2)

TNF Receptor (3)

Topoisomerase (1)

TRP Channel (2)

Tyrosinase (1)

Urotensin Receptor (2)

Virus Protease (2)

Xanthine Oxidase (1)

By Research Areas:

Cancer (241)

Cardiovascular Disease (96)

Endocrinology (36)

Infection (61)

Inflammation/Immunology (118)

Metabolic Disease (147)

Neurological Disease (146)

687

Inhibitors & Agonists

Screening Libraries

Dye Reagents

Biochemical Assay Reagents

217

Peptides

208

Natural
Products

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas

HY-U00427

PDE2/PDE10-IN-1
Phosphodiesterase (PDE) Neurological Disease

PDE2/PDE10-IN-1 is a phosphodiesterase 2 (PDE2) and PDE10 inhibitor with IC₅₀s of 29 and 480 nM, respectively.
HY-50865

PDE-9 inhibitor
Phosphodiesterase (PDE) Neurological Disease

PDE-9 inhibitor is useful for neurodegenerative diseases.

PDE2/PDE10-IN-1	Phosphodiesterase (PDE)	Neurological Disease
PDE2/PDE10-IN-1 is a phosphodiesterase 2 (PDE2) and *PDE10* inhibitor with IC₅₀s of 29 and 480 nM, respectively.

PDE-9 inhibitor	Phosphodiesterase (PDE)	Neurological Disease
PDE-9 inhibitor is useful for neurodegenerative diseases.

HY-130262

PDE1-IN-3	Phosphodiesterase (PDE)	Inflammation/Immunology
PDE1-IN-3, compound 4 (WO2019156861), is a selective human phosphodiesterase 1 (PDE1) inhibitor. PDE1-IN-3 inhibits PDE4D and PDE6AB with IC₅₀ values of 23.99 μM and 10 μM, respectively.

HY-101490

PDE1-IN-2	Phosphodiesterase (PDE)	Neurological Disease
PDE1-IN-2 is an inhibitor of *PDE1* extracted from patent WO2016/55618 A1, example 31; has IC₅₀ values of 6, 140 and 164 nM for PDE1C, PDE1B and PDE1A, respectvely.

HY-112704

PDE5-IN-2	Phosphodiesterase (PDE)	Cardiovascular Disease
PDE5-IN-2 is a potent, highly selective, and orally active *PDE5* inhibitor, with an IC₅₀ of 0.31 nM, less potently inhibits PDE2A, PDE10A, PDE4D2, and PDE6C, with IC₅₀s of 106, 46, 43, 1.2 nM, respectively. Anti-pulmonary arterial hypertension activity.

HY-117318

PDE12-IN-1	Phosphodiesterase (PDE)	Infection
PDE12-IN-1 is a potent and selective *PDE12* inhibitor with a pIC₅₀ value for enzyme inhibition of 9.1. PDE12-IN-1 increases 2′,5′-linked adenylate polymers (2-5A) levels, and the pEC₅₀ value is 7.7. PDE12-IN-1 shows antiviral activity.

HY-12813

PDE10-IN-1
Phosphodiesterase (PDE) Neurological Disease

PDE10-IN-1 is a potent PDE10-IN-1 inhibitor extracted from Patent WO 2013192273 A1, for treating CNS and metabolic disorders.
HY-124768

PDE12-IN-3
Phosphodiesterase (PDE) Infection Inflammation/Immunology

PDE12-IN-3 is a phosphodiesterase 12 (PDE12) inhibitor with a pXC₅₀ of 7.68. Antiviral activity.
HY-126137

PDE9-IN-1
Phosphodiesterase (PDE) Neurological Disease

PDE9-IN-1 is a potent, selective, and orally bioavailable phosphodiesterase-9A (PDE9A) Inhibitor with an IC₅₀ of 8.7 nM.

PDE10-IN-1	Phosphodiesterase (PDE)	Neurological Disease
PDE10-IN-1 is a potent PDE10-IN-1 inhibitor extracted from Patent WO 2013192273 A1, for treating CNS and metabolic disorders.

PDE12-IN-3	Phosphodiesterase (PDE)	Infection Inflammation/Immunology
PDE12-IN-3 is a phosphodiesterase 12 (PDE12) inhibitor with a pXC₅₀ of 7.68. Antiviral activity.

PDE9-IN-1	Phosphodiesterase (PDE)	Neurological Disease
PDE9-IN-1 is a potent, selective, and orally bioavailable phosphodiesterase-9A (PDE9A) Inhibitor with an IC₅₀ of 8.7 nM.

HY-115687

PDE4B-IN-2	Phosphodiesterase (PDE)
PDE4B-IN-2 is an orally active and selective *PDE4B* inhibitor (IC₅₀=15 nM) and exhibits >100-fold selectivity for PDE4B over 4D. PDE4B-IN-2 regulates cAMP in inflammatory cells and inhibits LPS-induced TNF-α production and neutrophil accumulation in mouse lungs. PDE4B-IN-2 reduces microglial and neutrophil activation, and improves behavioral deficits in a traumatic brain injury model in vivo. PDE4B-IN-2 also exhibits antidepressant-like effects.

HY-130695

*N-(Amino-PEG5)-N-bis(PEG4-acid)*	PROTAC Linker	Cancer
N-(Amino-PEG5)-N-bis(PEG4-acid) is a PEG-based PROTAC linker used in the synthesis of PROTACs. N-(Amino-PEG5)-N-bis(PEG4-acid) contains an amino group with two terminal carboxylic acids.

HY-135298

Soya fatty acids
Others Metabolic Disease

Soya fatty acids is a class of polyunsaturated fatty acids extracted from soybean.
HY-U00410

PDE4 inhibitor intermediate 1
Others Others

PDE4 inhibitor intermediate 1 is an intermediate for PDE4 inhibitor synthesis.
HY-30216

(R)-Leucic acid
D-α-Hydroxyisocaproic acid
Endogenous Metabolite Others

(R)-Leucic acid is an amino acid metabolite.
HY-U00352

PDE IV-IN-1
Phosphodiesterase (PDE) Inflammation/Immunology

PDE IV-IN-1 is an inhibitor of phosphodiesterase IV, used for the research of asthma, COPD or other inflammatory diseases.

Soya fatty acids	Others	Metabolic Disease
Soya fatty acids is a class of polyunsaturated fatty acids extracted from soybean.

PDE4 inhibitor intermediate 1	Others	Others
PDE4 inhibitor intermediate 1 is an intermediate for PDE4 inhibitor synthesis.

(R)-Leucic acid D-α-Hydroxyisocaproic acid	Endogenous Metabolite	Others
(R)-Leucic acid is an amino acid metabolite.

PDE IV-IN-1	Phosphodiesterase (PDE)	Inflammation/Immunology
PDE IV-IN-1 is an inhibitor of phosphodiesterase IV, used for the research of asthma, COPD or other inflammatory diseases.

HY-103160A

EHNA hydrochloride	Adenosine Deaminase Phosphodiesterase (PDE) Influenza Virus	Cancer Infection Neurological Disease Cardiovascular Disease
EHNA hydrochloride is a potent and selective dual inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2)(IC₅₀=4 μM) and adenosine deaminase (ADA). EHNA hydrochloride exerts a concentration inhibition of the cGMP-stimulated PDE II (cGs-PDE)(IC₅₀:0.8 μM (human), 2 μM (porcine myocardium)), but has smaller inhibitory effect on the unstimulated PDE2 activity. EHNA hydrochloride play roles in mediating diverse pharmacological responses, including antiviral, antitumour and antiarrhythmic effects.

HY-113025A

L-hydroxylysine dihydrochloride (2S,5R)-5-Hydroxylysine dihydrochloride	Endogenous Metabolite	Others
L-hydroxylysine dihydrochloride ((2S,5R)-5-Hydroxylysine dihydrochloride), an amino acid, is exclusive to collagen protein, which is formed by posttranslational hydroxylation of some lysine residues.

HY-Y0123

DL-Tyrosine	Others	Neurological Disease
DL-Tyrosine is an aromatic nonessential amino acid synthesized from the essential amino acid phenylalanine. DL-Tyrosine is a precursor for several important neurotransmitters (epinephrine, norepinephrine, dopamine).

HY-70069

GSK 256066 Trifluoroacetate GSK256066 (2,2,2-trifluoroacetic acid)	Phosphodiesterase (PDE)	Inflammation/Immunology
GSK 256066 Trifluoroacetate (GSK256066 2,2,2-trifluoroacetic acid) is a selective and high-affinity phosphodiesterase 4 (PDE) inhibitor, with an IC₅₀ of 3.2 pM for PDE4B; developed for the treatment of chronic obstructive pulmonary disease.

HY-12887

Piclamilast RP 73401; RPR 73401	Phosphodiesterase (PDE)	Cancer Inflammation/Immunology
Piclamilast (RP 73401) is a phosphodiesterase 4 (PDE4) inhibitor, with IC₅₀ values of 16 nM and 2 nM in pig aorta and eosinophil soluble, respectively.

HY-W017443

L-Asparagine monohydrate	Endogenous Metabolite	Metabolic Disease
L-Asparagine monohydrate ((-)-Asparagine monohydrate) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-U00439

Protein kinase inhibitors 1
DYRK Cancer

Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC₅₀ of 74 nM and K_d of 9.5 nM.
HY-135916

Biotin-C5-amino-C5-amino
PROTAC Linker Cancer

Biotin-C5-amino-C5-amino is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-100309

9-amino-CPT
9-Amino-20(S)-camptothecin
Topoisomerase Cancer

9-amino-CPT (9-amino-20(S)-camptothecin) is a topoisomerase I inhibitor with potent anticancer activity.

*Protein kinase inhibitors* 1**	DYRK	Cancer
Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC₅₀ of 74 nM and K_d of 9.5 nM.

Biotin-C5-amino-C5-amino	PROTAC Linker	Cancer
Biotin-C5-amino-C5-amino is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

*9-amino-CPT* 9-Amino-20(S)-camptothecin	Topoisomerase	Cancer
9-amino-CPT (9-amino-20(S)-camptothecin) is a topoisomerase I inhibitor with potent anticancer activity.

HY-12597

Quisqualic acid L-Quisqualic acid	iGluR mGluR	Neurological Disease
Quisqualic acid (L-Quisqualic acid), a natural analog of glutamate, is a potent and pan two subsets (iGluR and mGluR) of excitatory amino acid (EAA) agonist with an EC₅₀ of 45 nM and a K_i of 10 nM for mGluR1R. Quisqualic acid is isolated from the fruits of Quisqualis chinensis.

HY-59132

2-Amino-1-phenylethanol
Endogenous Metabolite Others

2-Amino-1-phenylethanol is an analogue of noradrenaline.

*2-Amino-1-phenylethanol*	Endogenous Metabolite	Others
2-Amino-1-phenylethanol is an analogue of noradrenaline.

HY-W002820

*2-Amino-5-phenylpyridine*	Endogenous Metabolite	Cancer
2-Amino-5-phenylpyridine is a mutagenic heterocyclic aromatic amine that is formed by pyrolysis of phenylalanine in proteins. 2-Amino-5-phenylpyridine is in broiled sardines and is considered as potentially carcinogenic.

HY-W050026S

Phenylacetylglutamine-D5 NSC 203800-D5; Phenylacetyl-L-glutamine-D5	Others	Others
Phenylacetylglutamine-D5 (NSC 203800-D5;Phenylacetyl-L-glutamine-D5) is a deuterated form of Phenylacetylglutamine. Phenylacetylglutamine is a colonic microbial metabolite from amino acid fermentation.

HY-W000450

5-Amino-4-oxopentanoic acid
Endogenous Metabolite Cardiovascular Disease

5-Amino-4-oxopentanoic acid is a non-protein amino acid that plays a rate-limiting role in heme biosynthesis.
HY-111643

6-Amino-5-azacytidine
Bacterial Infection

6-Amino-5-azacytidine inhibits the growth of bacteria E. coli.
HY-W010224

3-Amino-4-hydroxybenzoic acid
Endogenous Metabolite Metabolic Disease

3-Amino-4-hydroxybenzoic acid is an endogenous metabolite.
HY-W016734

2-Amino-5-ureidopentanoic acid
Endogenous Metabolite Metabolic Disease

2-Amino-5-ureidopentanoic acid is an endogenous metabolite.

5-Amino-4-oxopentanoic acid	Endogenous Metabolite	Cardiovascular Disease
5-Amino-4-oxopentanoic acid is a non-protein amino acid that plays a rate-limiting role in heme biosynthesis.

*6-Amino-5-azacytidine*	Bacterial	Infection
6-Amino-5-azacytidine inhibits the growth of bacteria E. coli.

3-Amino-4-hydroxybenzoic acid	Endogenous Metabolite	Metabolic Disease
3-Amino-4-hydroxybenzoic acid is an endogenous metabolite.

2-Amino-5-ureidopentanoic acid	Endogenous Metabolite	Metabolic Disease
2-Amino-5-ureidopentanoic acid is an endogenous metabolite.

HY-W012982

*3-Amino-2-oxazolidinone* AOZ	Endogenous Metabolite	Metabolic Disease
3-Amino-2-oxazolidinone (AOZ) is the metabolite of Furazolidone (HY-B1336). 3-Amino-2-oxazolidinone is always be detected as a indicator of furazolidone residues in vivo.

HY-140397

m-PEG2-Amino
PROTAC Linker Cancer

m-PEG2-Amino is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

m-PEG2-Amino	PROTAC Linker	Cancer
m-PEG2-Amino is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-W012708

3-Amino-4-methylpentanoic acid	Endogenous Metabolite	Others
3-Amino-4-methylpentanoic acid is a beta amino acid and positional isomer of L-leucine which is naturally produced in humans via the metabolism of L-leucine by the enzyme leucine 2,3-aminomutase.

HY-W016480

4-Amino-L-phenylalanine
Endogenous Metabolite Metabolic Disease

4-Amino-L-phenylalanine is an endogenous metabolite.

*4-Amino-L-phenylalanine*	Endogenous Metabolite	Metabolic Disease
4-Amino-L-phenylalanine is an endogenous metabolite.

HY-N0325

DL-Methionine	Parasite	Infection Inflammation/Immunology
DL-Methionine is an essential amino acid containing sulfur with oxidative stress defense effects. DL-Methionine can be used for animal natural feed. DL-Methionine also kills *H. rostochiensis* on potato plants.

HY-W012974

3-Amino-2-methylpropanoic acid	Endogenous Metabolite	Metabolic Disease Cardiovascular Disease
3-Amino-2-methylpropanoic acid could induce browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors.

HY-117109

Amino Tadalafil	Others
Amino Tadalafil is an analog of tadalafil. Tadalafil is a potent inhibitor of phosphodiesterase 5 with applications in several conditions, including erectile dysfunction, pulmonary arterial hypertension, and lower urinary tract dysfunction.

HY-136168

Mal-amino-sulfo
PROTAC Linker Cancer

Mal-amino-sulfo is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

*Mal-amino-sulfo*	PROTAC Linker	Cancer
Mal-amino-sulfo is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-117519

Amino-Tri-(carboxyethoxymethyl)-methane	ADC Linker PROTAC Linker	Cancer
Amino-Tri-(carboxyethoxymethyl)-methane is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(carboxyethoxymethyl)-methan is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-129476

L-Canaline	Parasite Endogenous Metabolite	Cancer Infection
L-Canaline is a nonprotein amino acid stored in many leguminous plants. L-Canaline is a cytotoxic metabolite catalyzed by L-canavanine and its arginase. L-Canaline is a potent and irreversible inhibitor of ornithine aminotransferase. L-Canaline inhibits the growth of the malaria parasite *Plasmodium falciparum* with an IC₅₀ of 297 nM. L-Canaline has anticancer and antiproliferative effects.

HY-W008005

Amino-PEG4-alcohol	PROTAC Linker ADC Linker	Cancer
Amino-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Amino-PEG4-alcohol is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-140179

Amino-PEG16-acid
PROTAC Linker Cancer

Amino-PEG16-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-133334

Amino-PEG7-acid
PROTAC Linker Cancer

Amino-PEG7-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140183

Amino-PEG25-acid
PROTAC Linker Cancer

Amino-PEG25-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140184

Amino-PEG28-acid
PROTAC Linker Cancer

Amino-PEG28-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140182

Amino-PEG24-acid
PROTAC Linker Cancer

Amino-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140176

Amino-PEG10-acid
PROTAC Linker Cancer

Amino-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140185

Amino-PEG32-acid
PROTAC Linker Cancer

Amino-PEG32-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140178

Amino-PEG14-acid
PROTAC Linker Cancer

Amino-PEG14-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140177

Amino-PEG12-acid
PROTAC Linker Cancer

Amino-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140186

Amino-PEG36-acid
PROTAC Linker Cancer

Amino-PEG36-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140180

Amino-PEG20-acid
PROTAC Linker Cancer

Amino-PEG20-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140181

Amino-PEG23-acid
PROTAC Linker Cancer

Amino-PEG23-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-W008794

4-(2-Amino-1-hydroxyethyl)-2-methoxyphenol hydrochloride
Endogenous Metabolite Metabolic Disease

4-(2-Amino-1-hydroxyethyl)-2-methoxyphenol hydrochloride is an endogenous metabolite.
HY-W014504

2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid
Endogenous Metabolite Metabolic Disease

2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid is an endogenous metabolite.
HY-23212

2-Amino-1,3-bis(carboxylethoxy)propane
PROTAC Linker Cancer

2-Amino-13-bis(carboxylethoxy)propane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-W016798

(S)-2-acetamido-4-amino-4-oxobutanoic acid
Endogenous Metabolite Metabolic Disease

(S)-2-acetamido-4-amino-4-oxobutanoic acid is an endogenous metabolite.
HY-128750

(Z)-4-Amino-4-oxobut-2-enoic acid
Endogenous Metabolite Metabolic Disease

(Z)-4-Amino-4-oxobut-2-enoic acid is an endogenous metabolite.
HY-140204

Amino-PEG9-alcohol
PROTAC Linker Cancer

Amino-PEG9-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140197

Amino-PEG12-Boc
PROTAC Linker Cancer

Amino-PEG12-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140206

Amino-PEG24-alcohol
PROTAC Linker Cancer

Amino-PEG24-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-23105

Amino-PEG6-amine
PROTAC Linker Cancer

Amino-PEG6-amine is a PEG-based (6 units) PROTAC linker can be used in the synthesis of PROTACs.
HY-140240

Amino-PEG6-Thalidomide
PROTAC Linker Cancer

Amino-PEG6-Thalidomide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140200

Amino-PEG36-Boc
PROTAC Linker Cancer

Amino-PEG36-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-130659

Amino-PEG8-amine
PROTAC Linker Cancer

Amino-PEG8-amine is a PEG-based (8 units) PROTAC linker can be used in the synthesis of PROTACs.
HY-140210

Amino-PEG9-amine
PROTAC Linker Cancer

Amino-PEG9-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-130447

Amino-PEG5-amine
PROTAC Linker Cancer

Amino-PEG5-amine is a PEG-based (5 units) PROTAC linker can be used in the synthesis of PROTACs.
HY-140199

Amino-PEG24-Boc
PROTAC Linker Cancer

Amino-PEG24-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140205

Amino-PEG12-alcohol
PROTAC Linker Cancer

Amino-PEG12-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140196

Amino-PEG10-Boc
PROTAC Linker Cancer

Amino-PEG10-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140209

Amino-PEG7-amine
PROTAC Linker Cancer

Amino-PEG7-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140195

Amino-PEG9-Boc
PROTAC Linker Cancer

Amino-PEG9-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140198

Amino-PEG20-Boc
PROTAC Linker Cancer

Amino-PEG20-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140193

Amino-PEG4-Boc
PROTAC Linker Cancer

Amino-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140207

Amino-PEG36-alcohol
PROTAC Linker Cancer

Amino-PEG36-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140211

Amino-PEG23-amine
PROTAC Linker Cancer

Amino-PEG23-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140194

Amino-PEG5-Boc
PROTAC Linker Cancer

Amino-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

*Amino-PEG16-acid*	PROTAC Linker	Cancer
Amino-PEG16-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

*Amino-PEG7-acid*	PROTAC Linker	Cancer
Amino-PEG7-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

*Amino-PEG25-acid*	PROTAC Linker	Cancer
Amino-PEG25-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

*Amino-PEG28-acid*	PROTAC Linker	Cancer
Amino-PEG28-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-135900

*Aniline-MPB-amino-C3-PBD*	ADC Cytotoxin Bacterial	Cancer
Aniline-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Aniline-MPB-amino-C3-PBD is a sequence-selective DNA minor-groove binding agent. Aniline-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity.

HY-130166

Amino-PEG9-acid
ADC Linker Cancer

Amino-PEG9-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-119417

Chloramben 3-Amino-2,5-dichlorobenzoic acid	Others	Others
Chloramben (3-Amino-2,5-dichlorobenzoic acid) is a pre-emergence herbicide used to control the seedlings of annual grasses and broadleaf weeds.

HY-D0227

Trometamol Tromethamine	Others	Metabolic Disease
Trometamol is a biologically inert amino alcohol of low toxicity, which buffers carbon dioxide and acids in vitro and in vivo. Trometamol is an effective amine compound for pH control in the physiological range.

HY-50071

*6-Amino-5-nitropyridin-2-one*	Nucleoside Antimetabolite/Analog	Others
6-Amino-5-nitropyridin-2-one is a pyridine base and used as a nucleobase of hachimoji DNA, in which it pairs with 5-aza-7-deazaguanine.

HY-N6030

(Rac)-Dencichin 2-Amino-3-(carboxyformamido)propanoic acid	Others	Others
(Rac)-Dencichin (2-Amino-3-(carboxyformamido)propanoic acid) is the racemate of Dencichin. Dencichin is a non-protein amino acid originally extracted from Panax notoginseng, and can inhibit HIF-prolyl hydroxylase-2 (PHD-2) activity.

HY-D0227A

Trometamol hydrochloride Tromethamine hydrochloride	Others	Metabolic Disease
Trometamol hydrochloride (Tromethamine hydrochloride) is a biologically inert amino alcohol of low toxicity, which buffers carbon dioxide and acids in vitro and in vivo. Trometamol hydrochloride is an effective amine compound for pH control in the physiological range.

HY-135901

*Py-MPB-amino-C3-PBD*	ADC Cytotoxin Bacterial	Cancer
Py-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Py-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity.

HY-135410

ABZ-amine Amino albendazole	Others	Infection
ABZ-amine (Amino albendazole) is an impurity of Albendazole. Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.

HY-W019799

Amino-PEG8-Boc
ADC Linker Cancer

Amino-PEG8-Boc is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-126942

Amino-PEG6-alcohol
ADC Linker Cancer

Amino-PEG6-OH is a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-130298

Amino-PEG11-OH
ADC Linker Cancer

Amino-PEG11-OH is non-cleavable 11 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-120761

Amino-PEG10-OH
ADC Linker Cancer

Amino-PEG10-OH is non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-W040245

Fmoc-amino-PEG5-acid
PROTAC Linker Cancer

Fmoc-amino-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-131124

7-Amino-3-chloro cephalosporanic acid 7-ACCA	Others	Others
7-Amino-3-chloro cephalosporanic acid (7-ACCA) is an important intermediate for the synthesis of the second generation cephalosporins Cefaclor (HY-B0198).

HY-130141

m-PEG6-amino-Mal
PROTAC Linker Cancer

m-PEG6-amino-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-W008279

Amino-PEG2-NH-Boc
PROTAC Linker Cancer

Amino-PEG2-NH-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-140224

Amino-PEG8-hydrazide-Boc
PROTAC Linker Cancer

Amino-PEG8-hydrazide-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140223

Amino-PEG4-hydrazide-Boc
PROTAC Linker Cancer

Amino-PEG4-hydrazide-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-130181

m-PEG4-amino-Mal
PROTAC Linker Cancer

m-PEG4-amino-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-B1122

L-Cycloserine (S)-Cycloserine; (S)-4-Amino-3-isoxazolidone	GABA Receptor HIV	Neurological Disease Cancer
L-Cycloserine ((S)-4-Amino-3-isoxazolidone) irreversibly inhibits GABA pyridoxal 5′-phosphate-dependent aminitransferase in E.

HY-140239

Amino-PEG4-benzyl ester
PROTAC Linker Cancer

Amino-PEG4-benzyl ester is a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-135974

Amino-PEG3-SS-acid
ADC Linker Cancer

Amino-PEG3-SS-acid is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140097

Amino-SS-PEG12-acid
ADC Linker Cancer

Amino-SS-PEG12-acid is a cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136041

Boc-amino-PEG3-SSPy
ADC Linker Cancer

Boc-amino-PEG3-SSPy is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-130955

Amino-bis-PEG3-TCO
ADC Linker Cancer

Amino-bis-PEG3-TCO is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-130972

Amino-bis-PEG3-DBCO
ADC Linker Cancer

Amino-bis-PEG3-DBCO is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136085

Amino-bis-PEG3-BCN
ADC Linker Cancer

Amino-bis-PEG3-BCN is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-112831

BI-409306	Phosphodiesterase (PDE)	Neurological Disease
BI-409306 is a potent and selective *PDE9A* inhibitor, with an IC₅₀ of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC₅₀, 1.4 µM), PDE1C (IC₅₀, 1.0 µM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC₅₀ all > 10 μM); BI-409306 can be used in the research of memory enhancement in CNS disorders.

HY-U00250

*β-Amino* Acid Imagabalin Hydrochloride** PD-0332334	Calcium Channel	Neurological Disease
β-Amino Acid Imagabalin Hydrochloride (PD-0332334) is a ligand for the α2δ subunit of the voltage-dependent calcium channel.

HY-130524

Amino-PEG4-CH2COOH	PROTAC Linker ADC Linker	Cancer
Amino-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Amino-PEG4-CH2COOH is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-13765

6-Thioguanine Thioguanine；2-Amino-6-purinethiol	SARS-CoV Deubiquitinase DNA Methyltransferase Autophagy Apoptosis Endogenous Metabolite	Cancer Infection Inflammation/Immunology
6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC₅₀s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.

HY-140251

Tri(Amino-PEG5-amide)-amine
PROTAC Linker Cancer

Tri(Amino-PEG5-amide)-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140249

Tri(Amino-PEG3-amide)-amine
PROTAC Linker Cancer

Tri(Amino-PEG3-amide)-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140250

Tri(Amino-PEG4-amide)-amine
PROTAC Linker Cancer

Tri(Amino-PEG4-amide)-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140082

Hydroxy-Amino-bis(PEG2-propargyl)
PROTAC Linker Cancer

Hydroxy-Amino-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-141147

7-O-(Amino-PEG4)-paclitaxel
PROTAC Linker Cancer

7-O-(Amino-PEG4)-paclitaxel is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140002

Amino-PEG1-C2-acid
PROTAC Linker Cancer

Amino-PEG1-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-103050

ML-030	Phosphodiesterase (PDE)	Inflammation/Immunology
ML-030 is a potent *PDE4* inhibitor, with IC₅₀ of 6.7 nM, 12.9 nM, 48.2 nM, 37.2 nM, 452 nM and 49.2 nM for PDE4A, PDE4A1, PDE4B1, PDE4B2, PDE4C1,and PDE4D2, respectively.

HY-N0215

L-Phenylalanine (S)-2-Amino-3-phenylpropionic acid	Calcium Channel iGluR Endogenous Metabolite	Metabolic Disease
L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca⁺ channels antagonist with a K_i of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (K_B of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals.

HY-W040270

Amino-PEG10-amine	PROTAC Linker	Cancer
Amino-PEG10-amine, a PEG-based PROTAC linker used to combine two mono diethylstilbestrol (DES)-based ligands, provides an alternative strategy for preparing more selective and active ER antagonists for endocrine therapy of breast cancer.

HY-42619

Amino-PEG4-C1-Boc
PROTAC Linker Cancer

Amino-PEG4-C1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-130577

Amino-PEG5-CH2COOH
PROTAC Linker Cancer

Amino-PEG5-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-133336

Amino-PEG12-CH2-Boc
PROTAC Linker Cancer

Amino-PEG12-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-133335

Amino-PEG10-CH2-Boc
PROTAC Linker Cancer

Amino-PEG10-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-W015088

Amino-PEG3-C2-Amine
PROTAC Linker Cancer

Amino-PEG3-C2-Amine is a PEG-based (3 units) PROTAC linker can be used in the synthesis of PROTACs.
HY-133332

Amino-PEG11-CH2COOH
PROTAC Linker Cancer

Amino-PEG11-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-133338

Amino-PEG36-CH2-Boc
PROTAC Linker Cancer

Amino-PEG36-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140189

Amino-PEG3-CH2COOH
PROTAC Linker Cancer

Amino-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-133337

Amino-PEG24-CH2-Boc
PROTAC Linker Cancer

Amino-PEG24-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-133333

Amino-PEG12-CH2COOH
PROTAC Linker Cancer

Amino-PEG12-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-22335

Amino-PEG4-C2-amine
PROTAC Linker Cancer

Amino-PEG4-C2-amine is a PEG-based (4 units) PROTAC linker can be used in the synthesis of PROTACs.

HY-140188

Amino-PEG6-amido-C16-COOH 17-(Amino-PEG6-ethylcarbamoyl)heptadecanoic acid	PROTAC Linker	Cancer
Amino-PEG6-amido-C16-COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-U00186

K134 OPC33509	Phosphodiesterase (PDE)	Cardiovascular Disease
K134 is a phosphodiesterase 3 (PDE3) inhibitor. The IC₅₀s of K134 toward *PDE3A, PDE3B, PDE5, PDE2 and PDE*4 are 0.1, 0.28, 12.1, >300 and >300 µM, respectively.

HY-A0132

N-Acetyl-D-glucosamine N-Acetyl-2-Amino-2-deoxy-D-glucose	Endogenous Metabolite	Metabolic Disease
N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of glucose.

HY-W008437

*(S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid* dihydrate**	Endogenous Metabolite	Metabolic Disease
(S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid dihydrate is an endogenous metabolite.

HY-130411

Amino-PEG11-amine	PROTAC Linker	Cancer
Amino-PEG11-amine, a PEG-based (12 units) PROTAC linker used to combine two mono diethylstilbestrol (DES)-based ligands, provides an alternative strategy for preparing more selective and active ER antagonists for endocrine therapy of breast cancer.

HY-W040165

Amino-PEG3-C2-acid
ADC Linker Cancer

Amino-PEG3-C2-acid is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136037

Boc-amino-PEG3-SS-acid
ADC Linker Cancer

Boc-amino-PEG3-SS-acid is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-115384

Amino-PEG5-C2-acid
ADC Linker Cancer

Amino-PEG5-C2-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-117977

FCPR03	Phosphodiesterase (PDE)	Inflammation/Immunology Neurological Disease
FCPR03 is a potent and selective phosphodiesterase 4 (PDE4) inhibitor with IC₅₀ values of 60 nM, 31 nM and 47 nM for PDE4 catalytic domain, *PDE4B1* and *PDE4D7, respectively. FCPR03 displays at least 2100-fold selectivity over other PDEs* (PDE1-3 and PDE5-11). FCPR03 has anti-inflammatory, neuroprotective and antidepressant-like effects.

HY-109586

BRL-50481	Phosphodiesterase (PDE)	Neurological Disease
BRL-50481 is a novel and selective inhibitor of *PDE7* with IC₅₀s of 0.15, 12.1, 62 and 490 μM for *PDE7A, PDE7B, PDE4* and *PDE3*, respectively.

HY-140099

Amino-ethyl-SS-PEG3-NHBoc
ADC Linker Cancer

Amino-ethyl-SS-PEG3-NHBoc is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-16900

Rolipram (R,S)-Rolipram; SB 95952; ZK 62711	Phosphodiesterase (PDE) Bacterial HIV	Neurological Disease Cancer
Rolipram is a selective phosphodiesterases *PDE4* inhibitor with IC₅₀s of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.

HY-W040168

Amino-PEG2-C2-acid
ADC Linker Cancer

Amino-PEG2-C2-acid is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-41461

*5-Amino-3H-imidazole-4-Carboxamide* 5-Aminoimidazole-4-carboxamide; AICA	Endogenous Metabolite	Others
5-Amino-3H-imidazole-4-Carboxamide (AICA) is an important precursor for the synthesis of purines in general and of the nucleobases adenine and guanine in particular.

HY-18252

Avanafil TA1790	Phosphodiesterase (PDE)	Cardiovascular Disease
Avanafil(TA-1790) is a potent and highly selective phosphodiesterase-5(PDE-5) inhibitor(IC50=5.2 nM) for erectile dysfunction; lower selectivity against PDE1, PDE6, and PDE11.

HY-16900A

(R)-(-)-Rolipram (R)-Rolipram; (-)-Rolipram	Phosphodiesterase (PDE)	Neurological Disease
(R)-(-)-Rolipram is the R-enantiomer of Rolipram. Rolipram is a selective inhibitor of phosphodiesterases *PDE4* with IC₅₀ of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.

HY-12318

IBMX 3-Isobutyl-1-methylxanthine; Isobutylmethylxanthine	Phosphodiesterase (PDE)	Inflammation/Immunology
IBMX is a broad-spectrum phosphodiesterase (PDE) inhibitor, with IC₅₀s of 6.5, 26.3 and 31.7 μM for *PDE3, PDE4* and *PDE5*, respectively.

HY-140262

Amino-Tri-(m-PEG4-ethoxymethyl)-methane
PROTAC Linker Cancer

Amino-Tri-(m-PEG4-ethoxymethyl)-methane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-15455

Roflumilast	Phosphodiesterase (PDE) RSV	Inflammation/Immunology
Roflumilast is a selective *PDE4* inhibitor with IC₅₀s of 0.7, 0.9, 0.7, and 0.2 nM for *PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1, PDE2, PDE3 or PDE*5 isoenzymes from various cells.

HY-B1258

4-(Aminomethyl)benzoic acid
Aminomethylbenzoic acid; α-Amino-p-toluic acid
Others Others

4-(Aminomethyl)benzoic acid is an unnatural amino acid derivative, is an antifibrinolytic.

HY-10469

GSK256066	Phosphodiesterase (PDE)	Inflammation/Immunology
GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380,000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7.

HY-140187

Amino-PEG36-CONH-PEG36-acid
PROTAC Linker Cancer

Amino-PEG36-CONH-PEG36-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140001

Amino-PEG3-C2-sulfonic acid
PROTAC Linker Cancer

Amino-PEG3-C2-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-140201

Amino-PEG6-amido-C16-Boc 17-(Amino-PEG6-ethylcarbamoyl)heptadecanoic t-butyl ester	PROTAC Linker	Cancer
Amino-PEG6-amido-C16-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-140202

Amino-PEG9-amido-C16-Boc 17-(Amino-PEG9-ethylcarbamoyl)heptadecanoic t-butyl ester	PROTAC Linker	Cancer
Amino-PEG9-amido-C16-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-102050

PF-05085727	Phosphodiesterase (PDE)	Neurological Disease
PF-05085727 is a potent, selective and brain penetrant inhibitor of cGMP-dependent *PDE2A* (IC₅₀=2 nM). PF-05085727 inhibits PDE2A >4,000-fold selectivity over PDE1 and PDE3-11.

HY-140190

Amino-PEG2-(CH2)3COOH
PROTAC Linker Cancer

Amino-PEG2-(CH2)3COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-W008568

Fmoc-amino-PEG3-CH2COOH
PROTAC Linker Cancer

Fmoc-amino-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140222

Amino-PEG2-C2-hydrazide-Boc
PROTAC Linker Cancer

Amino-PEG2-C2-hydrazide-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-136134

SS-bis-amino-PEG4-NHS ester
ADC Linker Cancer

SS-bis-amino-PEG4-NHS ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-100246

CI-1044 PD-189659	Phosphodiesterase (PDE)	Inflammation/Immunology
CI-1044 is an orally active *PDE4* inhibitor with IC₅₀s of 0.29, 0.08, 0.56, 0.09 μM for *PDE4A5, PDE4B2, PDE4C2* and *PDE4D3*, respectively.

HY-W021401

Amino-PEG3-C2-Azido
PROTAC Linker Cancer

Amino-PEG3-C2-Azido is a PEG-based PROTAC linker can be used in the synthesis of the PARP1 degrader iRucaparib-TP3 (HY-130645).
HY-141154

Amino-PEG4-Val-Cit-PAB-MMAE
ADC Linker Cancer

Amino-PEG4-Val-Cit-PAB-MMAE is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-21088

*3-Amino-2-piperidinone* Cyclo-ornithine	Endogenous Metabolite	Metabolic Disease
3-aminopiperidine-2-one is a metabolite from all living organisms. 3-aminopiperidine-2-one is a delta-lactam that is 2-piperidone substituted at position 3 by an amino group.

HY-130968

Amino-PEG4-bis-PEG3-propargyl
ADC Linker Cancer

Amino-PEG4-bis-PEG3-propargyl is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-130970

Amino-PEG4-bis-PEG3-methyltetrazine
ADC Linker Cancer

Amino-PEG4-bis-PEG3-methyltetrazine is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140534

4-(N-Boc-amino)-1,6-heptanedioic acid
PROTAC Linker Cancer

4-(N-Boc-amino)-1,6-heptanedioic acid is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-15426

PF-04957325
Phosphodiesterase (PDE) Cancer

PF-04957325 is a highly potent and selective PDE8 inhibitor, with IC₅₀s of 0.7 nM and 0.3 nM for PDE8A and PDE8B, respectively.

HY-129364A

5-A-RU 5-Amino-6-(D-ribitylAmino)uracil	Others	Inflammation/Immunology
5-A-RU (5-Amino-6-(D-ribitylamino)uracil), a precursor of bacterial Riboflavin, is a mucosal-associated invariant T (MAIT) cells activator. 5-A-RU forms potent MAIT-activating antigens via non-enzymatic reactions with small molecules, such as glyoxal and methylglyoxal, which are derived from other metabolic pathways.

HY-133298

Amino-PEG14-alcohol
H2N-PEG14-OH
PROTAC Linker Cancer

Amino-PEG14-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-131082

(R)-8-Azido-2-(Fmoc-amino)octanoic acid
ADC Linker Cancer

(R)-8-Azido-2-(Fmoc-amino)octanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-141250

Hydroxy-Amino-bis(PEG1-C2-Boc)
PROTAC Linker Cancer

Hydroxy-Amino-bis(PEG1-C2-Boc) is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-122641

Deltasonamide 1
Phosphodiesterase (PDE) Cancer

Deltasonamide 1 is a PDE6δ-KRas inhibitor, with a K_D of 203 pM.

HY-101312

Cilostamide OPC3689	Phosphodiesterase (PDE)	Cardiovascular Disease
Cilostamide is a selective and potent *PDE3* inhibitor, with IC₅₀s of 27 nM and 50 nM for PDE3A and PDE3B, respectively, and has antithrombotic and anti-intimal hyperplastic activity.

HY-122942

Moracin M	Phosphodiesterase (PDE) Endogenous Metabolite	Inflammation/Immunology
Moracin M, a phenolic component in the skin of Morus alba L., is a potent phosphodiesterase-4 (PDE4) inhibitor with IC₅₀ values of 2.9, 4.5, >40, and >100 μM for PDE4D2, PDE4B2, PDE5A1, and PDE9A2, respectively. Moracin M has anti-inflammatory activity.

HY-128358

MR-L2	Phosphodiesterase (PDE)	Neurological Disease
MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4), activates representative PDE4 long-isoform variants (PDE4A4, PDE4B1, PDE4C3, PDE4D5). MR-L2 suppresses PGE2-induced MDCK cell cyst formation with an EC₅₀ of 1.2 µM.

HY-101661

Win 58237	Phosphodiesterase (PDE)	Cardiovascular Disease
Win 58237 is a cyclic nucleotide phosphodiesterase (PDE) inhibitor, with K_i of 170 nM for PDE V, possessing vasorelaxant activity.

HY-140245

N-(Amino-PEG3)-N-bis(PEG3-acid)
PROTAC Linker Cancer

N-(Amino-PEG3)-N-bis(PEG3-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-14930A

Mirodenafil dihydrochloride SK-3530 dihydrochloride	Phosphodiesterase (PDE)	Others
Mirodenafil dihydrochloride (SK3530 dihydrochloride) is a phosphodiesterase type 5 (PDE-5) inhibitor developed for the treatment of erectile dysfunction.

HY-12501A

ITI-214	Phosphodiesterase (PDE)	Neurological Disease
ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = 58 pM).

HY-136090

Amino-PEG4-bis-PEG3-N3
ADC Linker Cancer

Amino-PEG4-bis-PEG3-N3 is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140254

N-(Amino-PEG3)-N-bis(PEG4-Boc)
PROTAC Linker Cancer

N-(Amino-PEG3)-N-bis(PEG4-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140253

N-(Amino-PEG3)-N-bis(PEG3-Boc)
PROTAC Linker Cancer

N-(Amino-PEG3)-N-bis(PEG3-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140255

N-(Amino-PEG4)-N-bis(PEG4-Boc)
PROTAC Linker Cancer

N-(Amino-PEG4)-N-bis(PEG4-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-W007713

Fmoc-8-amino-3,6-dioxaoctanoic acid Fmoc-NH-PEG2-CH2COOH	ADC Linker	Cancer
Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-14930

Mirodenafil
SK3530
Phosphodiesterase (PDE) Endocrinology

Mirodenafil(SK3530) is a phosphodiesterase type 5 (PDE-5) inhibitor developed for the treatment of erectile dysfunction.

HY-B0392

(S)-(+)-Rolipram (+)-Rolipram; (S)-Rolipram	Phosphodiesterase (PDE) Apoptosis	Inflammation/Immunology Cancer
(S)-(+)-Rolipram is a PDE4-inhibitor and an anti-inflammatory agent, less potent than its R enantiomer.

HY-140532

N-(Amino-PEG4)-N-Biotin-PEG4-acid
PROTAC Linker Cancer

N-(Amino-PEG4)-N-Biotin-PEG4-acid is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-N1860

3-O-Methylquercetin	Phosphodiesterase (PDE)	Inflammation/Immunology
3-O-Methylquercetin (3-MQ), a main constituent of Rhamnus nakaharai, inhibits total cAMP and cGMP-phosphodiesterase (PDE) of guinea pig trachealis. 3-O-Methylquercetin (3-MQ) exhibits IC₅₀ values of 31.9 μM， 86.9 μM， 18.6 μM and 1.6 μM for PDE1, PDE5, PDE2 and PDE4, respectively.

HY-12501

ITI214 free base	Phosphodiesterase (PDE)	Neurological Disease
ITI-214 (free base) is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = 58 pM).

HY-128349

MT-3014	Phosphodiesterase (PDE)	Neurological Disease
MT-3014 is a potent, highly selective and brain-penetrated *phosphodiesterase 10A (PDE* 10A) inhibitor, with IC₅₀*s of 0.062 nM and 0.09 nM for human PDE* 10A and bovine PDE 10A, respectively.

HY-W021425

*(2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride*	Endogenous Metabolite	Metabolic Disease
(2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride is an endogenous metabolite.

HY-140191

Amino-PEG4-(CH2)3CO2H
PROTAC Linker Cancer

Amino-PEG4-(CH2)3CO2H is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-10978

Crisaborole AN-2728; PF-06930164	Phosphodiesterase (PDE)	Inflammation/Immunology
Crisaborole (AN-2728) is a potent inhibitor of *PDE4* and cytokine release; inhibit PDE4 with an IC₅₀ of 0.49 μM.

HY-100217

D,L-3-Indolylglycine α-Amino-1H-indole-3-acetic acid	Others	Others
D,L-3-Indolylglycine is an unnatural amino acid that is very similar to Tryptophan, with the indole moiety directly attached to the α-position.

HY-117571

BPN14770	Phosphodiesterase (PDE)	Neurological Disease
BPN14770 is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor with IC₅₀s of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively.

HY-129364

5-A-RU hydrochloride 5-Amino-6-(D-ribitylAmino)uracil hydrochloride	Others	Inflammation/Immunology
5-A-RU hydrochloride (5-Amino-6-(D-ribitylamino)uracil hydrochloride), a precursor of bacterial Riboflavin, is a mucosal-associated invariant T (MAIT) cells activator. 5-A-RU hydrochloride forms potent MAIT-activating antigens via non-enzymatic reactions with small molecules, such as glyoxal and methylglyoxal, which are derived from other metabolic pathways.

HY-131255

Ziprasidone amino acid Ziprasidone Impurity C; Ziprasidone open ring impurity	5-HT Receptor Dopamine Receptor	Neurological Disease
Ziprasidone amino acid (Ziprasidone Impurity C) is an impurity of Ziprasidone. Ziprasidone is a combined 5-HT (serotonin) and dopamine receptor antagonist. Ziprasidone exhibits potent effects of antipsychotic activity .

HY-14518

Aminopterin 4-Aminofolic acid; APGA	Antifolate	Cancer Inflammation/Immunology
Aminopterin (4-Aminofolic acid), the 4-amino derivative of folic acid, is a folic acid antagonist. Aminopterin catalyses the reduction of folic acid to tetrahydrofolic acid, and competitively inhibits dihydrofolate reductase (DHFR) with a K_i of 3.7 pM. Aminopterin has anticancer and immunosuppressive activity. Aminopterin is used in treatment of pediatric leukemia.

HY-N7384

Vitamin B15 Pangamic Acid	Others	Cancer Metabolic Disease Inflammation/Immunology Neurological Disease
Vitamin B15 (Pangamic Acid) is a natural, ubiquitously in plant seeds substance and can used be as an agent stimulating cellular respiration. Vitamin B15 contains D-gluconodimethyl amino acetic acid. Vitamin B15 is also a immune-correcting agent. Vitamin B15 can be used for wide range of diseases.

HY-140928

Biotin-PEG4-amino-t-Bu-DADPS-C3-alykne
PROTAC Linker Cancer

Biotin-PEG4-amino-t-Bu-DADPS-C3-alykne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140921

Biotin-PEG4-amino-t-Bu-DADPS-C6-azide
PROTAC Linker Cancer

Biotin-PEG4-amino-t-Bu-DADPS-C6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-130957

Amino-PEG6-amido-bis-PEG5-N3
ADC Linker Cancer

Amino-PEG6-amido-bis-PEG5-N3 is a cleavable 11 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-141056

N-(m-PEG4)-N'-(amino-PEG3)-Cy5
PROTAC Linker Cancer

N-(m-PEG4)-N'-(amino-PEG3)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-W028690

DNMDP	Phosphodiesterase (PDE)	Cancer
DNMDP, a phosphodiesterase 3A (PDE3A) inhibitor, is a potent and selective cancer cell cytotoxic agent. DNMDP binding to PDE3A promotes an interaction between PDE3A and Schlafen 12 (SLFN12). DNMDP shows clear cell-selective cytotoxicity.

HY-131005

Ehp inhibitor 2
Ephrin Receptor Cancer

Ehp inhibitor 2 is a Eph family tyrosine kinase inhibitor.
HY-15485

Zardaverine
Phosphodiesterase (PDE) Inflammation/Immunology

Zardaverine is a newly developed dual-selective PDE3/4 inhibitor with IC50 values of 0.5 uM and 0.8 uM respectively.

HY-122751

(R)-DNMDP	Phosphodiesterase (PDE)	Cancer
(R)-DNMDP is a potent and selective cancer cell cytotoxic agent. (R)-DNMDP, the R-form of DNMDP, binds *PDE3A* directly. DNMDP binding to PDE3A promotes an interaction between PDE3A and Schlafen 12 (SLFN12).

HY-131165

*Amoxicillin trihydrate mixture with* potassium clavulanate (4:1)**	Antibiotic	Infection
Amoxicillin (trihydrate) mixture with potassium clavulanate (4:1) is a mixture of 4 part Amoxicillin trihydrate to 1 part Potassium clavulanate. Amoxicillin trihydrate is a semisynthetic β-lactam antibiotic.

HY-131164

*Potassium clavulanate mixture with* silicon dioxide (1:1)**	Antibiotic	Infection
Potassium clavulanate mixture with silicon dioxide (1:1) is a powdered mixture of 1 part Potassium clavulanate to 1 part Silicon dioxide.

HY-100640

Roflumilast Impurity E	Phosphodiesterase (PDE)	Inflammation/Immunology
Roflumilast Impurity E is the impurity of Roflumilast. Roflumilast(Daliresp) is a drug which acts as a selective and long-acting inhibitor of the enzyme *PDE-4* with an IC₅₀ value of 0.8 nM.

HY-17464

Cilostazol OPC 13013	Phosphodiesterase (PDE) Autophagy	Cardiovascular Disease Cancer
Cilostazol (OPC 13013) is a potent and selective inhibitor of *phosphodiesterase (PDE) 3A, the isoform of PDE* 3 in the cardiovascular system, with an IC₅₀ of 0.2 μM.

HY-133327

Amino-PEG12-amine
H2N-PEG12-CH2CH2NH2
PROTAC Linker Cancer

Amino-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-133329

Amino-PEG15-amine
H2N-PEG15-CH2CH2NH2
PROTAC Linker Cancer

Amino-PEG15-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-133330

Amino-PEG27-amine
H2N-PEG27-CH2CH2NH2
PROTAC Linker Cancer

Amino-PEG27-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-133328

Amino-PEG13-amine
H2N-PEG13-CH2CH2NH2
PROTAC Linker Cancer

Amino-PEG13-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-101644A

Saterinone hydrochloride
BDF 8634 hydrochloride
Phosphodiesterase (PDE) Cardiovascular Disease

Saterinone hydrochloride is a phosphodiesterase III (PDE III) inhibitor.

HY-N0014

Icariin Ieariline	Phosphodiesterase (PDE) PPAR Autophagy	Inflammation/Immunology Cardiovascular Disease Cancer
Icariin is a flavonol glycoside. Icariin inhibits *PDE5* and *PDE4* activities with IC₅₀s of 432 nM and 73.50 μM, respectively. Icariin also is a PPARα activator.

HY-12472

Balipodect TAK-063	Phosphodiesterase (PDE)	Neurological Disease
Balipodect (TAK-063) is a highly potent, selective and orally active PDE10A inhibitor with IC₅₀ of 0.30 nM; >15000-fold selectivity over other PDEs.

HY-100639

Roflumilast N-oxide
Phosphodiesterase (PDE) Inflammation/Immunology

Roflumilast N-oxide is a PDE type 4 inhibitor.
HY-B0327A

Irsogladine maleate
Dicloguamine maleate; MN1695
mAChR Phosphodiesterase (PDE) Inflammation/Immunology

Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.
HY-14252

Milrinone
Win 47203
Phosphodiesterase (PDE) Cardiovascular Disease

Milrinone is a PDE3 inhibitor, and also an inotrope and vasodilator.
HY-B0327

Irsogladine
Dicloguamine
mAChR Phosphodiesterase (PDE) Inflammation/Immunology

Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.

HY-B1639

Enoximone	Phosphodiesterase (PDE)	Inflammation/Immunology Cardiovascular Disease
Enoximone is an inotropic vasodilating agent and a selective and orally active phosphodiesterase III (PDE3) inhibitor with an IC₅₀ of 5.9 μM. Enoximone induces vasodilatation and increases intracellular levels of cAMP by inhibiting cGMP-inhibited PDE. Enoximone also exhibits *PDE4* inhibitory effect with an IC₅₀ of 21.1 μM for myocardial PDE4A. Enoximone has the potential for congestive heart failure research and has bronchodilatory, antiasthma and anti-inflammatory effects.

HY-100933

MY-5445
Phosphodiesterase (PDE) Cardiovascular Disease

MY-5445 is a specific phosphodiesterase type 5 (PDE5) inhibitor. MY-5445 selectively inhibits cGMP PDE with a K_i of 1.3 μM.

HY-103493

TAK-915	Phosphodiesterase (PDE)	Neurological Disease
TAK-915 is a potent, selective, brain-penetrant and orally active phosphodiesterase 2A (PDE2A) inhibitor with an IC₅₀ of 0.61 nM. TAK-915 is >4100-fold more selectivity for *PDE2A* than PDE1A. TAK-915 has the potential for neuropsychiatric and neurodegenerative disorders treatment.

HY-15441

PF-04447943	Phosphodiesterase (PDE)	Neurological Disease
PF-04447943 is a potent inhibitor of human recombinant *PDE9A* (IC₅₀=12 nM) with >78-fold selectivity, respectively, over other PDE family members (IC₅₀>1000 nM).

HY-B0442

Vardenafil
Phosphodiesterase (PDE) Endocrinology

Vardenafil is a PDE5 inhibitor used for treating erectile dysfunction.
HY-19830

AN3199
Phosphodiesterase (PDE) Inflammation/Immunology

AN3199 is a PDE4 inhibitor with IC50 of 94.5 nM.
HY-13927

Acetildenafil
Phosphodiesterase (PDE)

Acetildenafil is a derivative of the phosphodiesterase 5 (PDE5) inhibitor Sildenafil.
HY-14254A

Olprinone
Loprinone
Phosphodiesterase (PDE) Cardiovascular Disease

Olprinone(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.
HY-121879

SHP836
Phosphatase Cancer

SHP836 is a SHP2 allosteric inhibitor, with an IC₅₀ of 12 μM for the full length SHP2.
HY-100118

BW-A 78U
Phosphodiesterase (PDE) Inflammation/Immunology

BW-A 78U is a PDE4 inhibitor with an IC₅₀ of 3 μM.
HY-B0442A

Vardenafil hydrochloride
Phosphodiesterase (PDE) Cardiovascular Disease

Vardenafil Hcl is a PDE5 inhibitor used for treating erectile dysfunction.
HY-14550

TP-10
Phosphodiesterase (PDE) Cardiovascular Disease

TP-10 is a PDE10A inhibitor with IC50 of 0.8 nM.

HY-14520

Tetrahydrofolic acid L-5,6,7,8-Tetrahydrofolic acid; L-Tetrahydrofolic acid	Endogenous Metabolite	Metabolic Disease
Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid.

HY-12085

Apremilast CC-10004	Phosphodiesterase (PDE) Apoptosis TNF Receptor	Inflammation/Immunology
Apremilast (CC-10004) is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC₅₀ of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC₅₀ of 104 nM.

HY-14254

Olprinone Hydrochloride
Loprinone (Hydrochloride)
Phosphodiesterase (PDE) Cardiovascular Disease

Olprinone Hcl(Loprinone Hcl) is a selective phosphodiesterase 3 (PDE3) inhibitor.
HY-U00374

Sch59498
Phosphodiesterase (PDE) Neurological Disease

Sch59498 is a potent inhibitor of phosphodiesterase 1c (Pde1c).
HY-15444

D159687
Phosphodiesterase (PDE) Neurological Disease

D159687 is a selective PDE4D inhibitor.
HY-14992

Bay 60-7550
BAY 607550
Phosphodiesterase (PDE) Neurological Disease

Bay 60-7550 is a potent and selective PDE2 inhibitor with a K_i of 3.8 nM.

HY-50098

Mardepodect PF-2545920	Phosphodiesterase (PDE)	Neurological Disease
Mardepodect (PF-2545920) is a potent, orally active and selective *PDE10A* inhibitor with an IC₅₀ of 0.37 nM, with >1000-fold selectivity over other *PDEs*. Mardepodect can cross the blood-brain barrier.

HY-50098A

Mardepodect hydrochloride PF-2545920 hydrochloride	Phosphodiesterase (PDE)	Cancer
Mardepodect hydrochloride (PF-2545920 hydrochloride) is a potent, orally active and selective *PDE10A* inhibitor with an IC₅₀ of 0.37 nM, with >1000-fold selectivity over other *PDEs*. Mardepodect hydrochloride can cross the blood-brain barrier.

HY-111371

PF-05180999
Phosphodiesterase (PDE) Neurological Disease

PF-05180999 is a phosphodiesterase 2A (PDE2A) inhibitor, with an IC₅₀ of 1.6 nM.

HY-B0809

Theophylline 1,3-Dimethylxanthine; Theo-24	Adenosine Receptor Phosphodiesterase (PDE) Autophagy Endogenous Metabolite	Cancer
Theophylline is a nonselective phosphodiesterase (PDE) inhibitor, adenosine receptor blocker, and histone deacetylase (HDAC) activator.

HY-90009A

Tadalafil
IC-351
Phosphodiesterase (PDE) Apoptosis Cardiovascular Disease

Tadalafil (IC-351) is a PDE5 inhibitor with an IC₅₀ value of 1.8 nM.
HY-101693

Senazodan
Phosphodiesterase (PDE) Cardiovascular Disease

Senazodan is a Ca²⁺ sensitiser, and also shows inhibition effect on PDE III.
HY-101826

ER21355
Phosphodiesterase (PDE) Cancer

ER21355 is an inhibitor of phosphodiesterase 5 (PDE5), used for treatment of prostatic diseases.
HY-100615

Revizinone
R80122
Phosphodiesterase (PDE) Cardiovascular Disease

Revizinone is a novel selective phosphodiesterase (PDE) inhibitor with IC50 values on this enzyme to 0.036 microM.

HY-117604

THPP-1	Phosphodiesterase (PDE)	Neurological Disease
THPP-1, a SGC chemical probe, is a potent and orally bioavailable phosphodiesterase 10A (PDE10A) inhibitor, with K_i values of 1 nM and 1.3 nM for human and rat PDE10A, respectively. THPP-1 has excellent pharmacokinetic properties in preclinical species.

HY-136569

DSR-141562	Phosphodiesterase (PDE)	Neurological Disease
DSR-141562 is a novel, orally active, and selective brain-penetrant phosphodiesterase 1 (PDE1) inhibitor. DSR-141562 shows preferential selectivity for human PDE1B with an IC₅₀ of 43.9 nM, and the IC₅₀ values for human PDE1A and 1C are 97.6 and 431.8 nM, respectively. DSR-141562 can be used for the study of positive symptoms, negative symptoms and cognitive impairments associated with schizophrenia.

HY-128879

VP3.15	Phosphodiesterase (PDE) GSK-3	Neurological Disease
VP3.15 is a potent, orally bioavailable and CNS-penetrant dual *phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3* inhibitor, with IC₅₀s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS).

HY-18253

Udenafil
DA8159
Phosphodiesterase (PDE) Others

Udenafil(DA8159) is a PDE5 inhibitor used in urology to treat erectile dysfunction.

HY-15025A

Sildenafil citrate UK-92480 citrate	Phosphodiesterase (PDE) Autophagy Apoptosis	Cardiovascular Disease Cancer
Sildenafil citrate is a potent phosphodiesterase type 5 (PDE5) inhibitor with IC₅₀ of 5.22 nM.

HY-114303

CM-675	Phosphodiesterase (PDE) HDAC	Neurological Disease
CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitor, with IC₅₀ values of 114 nM and 673 nM for PDE5 and HDAC1, respectively. CM-675 has potential to treat Alzheimer’s disease.

HY-128879A

VP3.15 dihydrobromide	Phosphodiesterase (PDE) GSK-3	Neurological Disease
VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual *phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3* inhibitor, with IC₅₀s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 dihydrobromide has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS).

HY-12913

AMG 579
Phosphodiesterase (PDE) Neurological Disease

AMG 579 is a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) with an IC₅₀ of 0.1 nM.

HY-B0204A

Pimobendan hydrochloride UD-CG115 hydrochloride	Phosphodiesterase (PDE)	Cardiovascular Disease
Pimobendan hydrochloride (UD-CG115 hydrochloride) is a selective inhibitor of PDE3 with IC₅₀ of 0.32 μM.

HY-U00254

L791943
Phosphodiesterase (PDE) Neurological Disease

L791943 is a potent, selective Phosphodiesterase-4 (PDE4) inhibitor with an IC₅₀ of 4.2 nM.
HY-B0204

Pimobendan
UD-CG115
Phosphodiesterase (PDE) Cardiovascular Disease

Pimobendan (UD-CG115) is a selective inhibitor of PDE3 with IC₅₀ of 0.32 μM.

HY-19373

RWJ-445167 3DP-10017	Thrombin Factor Xa	Cardiovascular Disease
RWJ-445167 (3DP-10017) is a dual inhibitor of thrombin and factor Xa with K_i of 4.0 nM and 230 nM, respectively, exhibiting potent antithrombotic activity.

HY-16787

ICA-121431	Sodium Channel	Cardiovascular Disease
ICA-121431 is a nanomolar potent and broad-spectrum voltage-gated sodium channel (Na_v) blocker, shows equipotent selectivity for human Na_v1.1 and Na_v1.3 subtypes with IC₅₀ values of 13 nM and 23 nM, respectively. ICA-121431 shows less potent inhibition of Na_v1.2 (IC₅₀=240 nM) and 1,000 fold selectivity against Na_v1.4, Na_v1.6, and the TTX-resistant human Na_v1.5 and Na_v1.8 channels (IC₅₀s >10 µM).

HY-12085S

Apremilast D5 CC-10004 D5	Phosphodiesterase (PDE) TNF Receptor Apoptosis	Inflammation/Immunology
Apremilast D5 (CC-10004 D5) is a deuterium labeled Apremilast. Apremilast is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC₅₀ of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC₅₀ of 104 nM.

HY-16558

Butein 2’,3,4,4’-tetrahydroxy Chalcone	EGFR Autophagy Apoptosis Phosphodiesterase (PDE)	Cancer
Butein, isolated from Dalbergia odorifera T. Chen, is a cAMP-specific *PDE* inhibitor with an IC₅₀ of 10.4 μM for *PDE4. Butein is a specific protein tyrosine kinase inhibitor with IC₅₀s of 16 and 65 μM for EGFR* and p60^c-src in HepG2 cells. Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a. Butein is a SIRT1 activator (STAC).

HY-123210

Lodenafil
Hydroxyhomosildenafil
Phosphodiesterase (PDE) Endocrinology

Lodenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor for the treatment of erectile dysfunction (ED).

HY-15025

Sildenafil UK-92480	Phosphodiesterase (PDE) Autophagy Apoptosis	Cardiovascular Disease Cancer
Sildenafil (UK-92480) is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC₅₀ of 5.22 nM.

HY-15178

Oglemilast GRC 3886	Phosphodiesterase (PDE)	Inflammation/Immunology
Oglemilast (GRC 3886) is a potent and orally active phosphodiesterase-4 (PDE4) inhibitor with an IC₅₀ of 0.5 nM for PDE4D3. Oglemilast inhibits pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo. Oglemilast has the potential for inflammatory airway diseases.

HY-12740

Lotamilast
RVT-501; E6005
Phosphodiesterase (PDE) Inflammation/Immunology

Lotamilast (RVT-501; E6005) is a selective phosphodiesterase 4 (PDE4) inhibitor with an IC₅₀ of 2.8 nM.

HY-W003445

4-Bromo-3-hydroxybenzoic acid	Endogenous Metabolite	Neurological Disease
4-Bromo-3-hydroxybenzoic acid is a metabolite of Brocresine and a histidine decarboxylase (HDC) inhibitor with IC₅₀s of 1 mM for both rat fetal and rat gastric HDC. 4-Bromo-3-hydroxybenzoic acid also inhibits *aromatic-L-amino* acid decarboxylase from hog kidney and rat gastric mucosa in vitro with IC₅₀**s of 1 mM for both enzymes.

HY-U00439A

*Protein kinase inhibitors* 1 hydrochloride** (E)-5-((2-Oxo-6'-(piperazin-1-yl)-1,2-dihydro-[3,3'-bipyridin]-5-yl)methylene)thiazolidine-2,4-dione hydrochloride	DYRK	Cancer
Protein kinase inhibitors 1 hydrochloride is a potent HIPK2 inhibitor, with IC₅₀s of 136 and 74 nM for HIPK1 and HIPK2, and a K_d of 9.5 nM for HIPK2.

HY-135848

N-Methylbenzamide
Phosphodiesterase (PDE) Cancer

N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor. N-Methylbenzamide has anti-cancer activity.
HY-104028

BAY 73-6691
(R)-BAY 73-6691
Phosphodiesterase (PDE) Neurological Disease

BAY 73-6691 ((R)-BAY 73-6691) is a potent, brain penetrant, and selective PDE9A inhibitor.

HY-19102

NSP-805	Phosphodiesterase (PDE)	Cardiovascular Disease
NSP-805 is a potent and selective inhibitor of guinea pig cardiac phosphodiesterase 3 (PDE3), and a cardiotonic agent with vasodilator properties.

HY-U00136

Win-62005	Phosphodiesterase (PDE)	Cardiovascular Disease
Win-62005 is a cyclic AMP phosphodiesterase III (PDE III) inhibitor with K_is of 25 and 26 nM for rat heart and canine aorta, respectively.

HY-W012037

8-Hydroxyquinoline hemisulfate 8-Quinolinol hemisulfate	Bacterial Antibiotic	Infection
8-Hydroxyquinoline hemisulfate (8-Quinolinol hemisulfate) is a monoprotic bidentate chelating agent, exhibits antiseptic, disinfectant, and pesticide properties, functioning as a transcription inhibitor.

HY-W014502

D-Kynurenine	Aryl Hydrocarbon Receptor Endogenous Metabolite	Cancer
D-kynurenine, a metabolite of D-tryptophan, can serve as the bioprecursor of kynurenic acid (KYNA) and 3-hydroxykynurenine. D-Kynurenine is an agonist for G protein-coupled receptor, GPR109B. D-Kynurenine is a substrate in a fluorometric assay of D-amino acid oxidase. D-kynurenine promotes epithelial-to-mesenchymal transition via activating aryl hydrocarbon receptor (AHR).

HY-P1497

Bradykinin (1-3)	Bradykinin Receptor	Cardiovascular Disease Endocrinology
Bradykinin (1-3) is a 3-amino acid residue peptide. Bradykinin (1-3) is an amino-truncated Bradykinin peptide, cleaved by Prolyl endopeptidase.

HY-W018555

D-Cysteine	Endogenous Metabolite Bacterial	Infection Neurological Disease
D-Cysteine is the D-isomer of cysteine and a powerful inhibitor of *Escherichia coli* growth. D-cysteine is mediated by D-amino acid oxidase to produce H₂S and is a neuroprotectant against cerebellar ataxias. D-Cysteine could inhibit the growth and cariogenic virulence of dual-species biofilms formed by *S. mutans* and *S. sanguinis*.

HY-15297

Vesnarinone OPC-8212	Phosphodiesterase (PDE) HIV	Infection
Vesnarinone is a quinolinone derivative, and its pharmacodynamic effects include inhibition of phosphodiesterase III (PDE3) activity, increases in calcium flux and decreases in potassium flux.

HY-N0717

L-Valine
Endogenous Metabolite Others

L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid.

HY-10790

Cilomilast SB-207499	Phosphodiesterase (PDE)	Inflammation/Immunology
Cilomilast(SB 207499; Ariflo) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity.

HY-P0198

Neuropeptide Y (29-64), amide, human Human neuropeptide Y (29-64)	Neuropeptide Y Receptor	Neurological Disease Endocrinology
Neuropeptide Y (29-64), amide, human is a biologically active 36-amino acid peptide.

HY-N0771

L-Isoleucine
Endogenous Metabolite Others

L-isoleucine is a nonpolar hydrophobic amino acid. L-Isoleucine is an essential amino acid.

HY-135813

LtaS-IN-1	Bacterial	Infection
LtaS-IN-1 (compound 1771) is a potent small-molecule inhibitor of Lipoteichoic acid (LTA) synthesis in multidrug-resistant (MDR) E. faecium and by altering the cell wall morphology. LtaS-IN-1 alone inhibits Enterococcus.spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 combination with antibiotics abolishs multidrug-resistant E. faecium growth almost completely.

HY-125957

A-3 hydrochloride	PKA Casein Kinase CaMK PKC	Others
A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It against PKA (K_i=4.3 µM), casein kinase II (K_i=5.1 µM) and myosin light chain kinase (MLCK) (K_i=7.4 µM). A-3 hydrochloride also inhibits PKC and casein kinase I with K_i values of 47 µM and 80 µM, respectively.

HY-U00179

CDC801	Phosphodiesterase (PDE) TNF Receptor	Cancer
CDC801 is a potent and orally active phosphodiesterase 4 (PDE4) and tumor necrosis factor-α (TNF-α) inhibitor with IC₅₀ of 1.1 μM and 2.5 μM, respectively.

HY-14841

Gisadenafil UK-369003	Phosphodiesterase (PDE)	Neurological Disease
Gisadenafil (UK-369003) is a specific, orally active phosphodiesterase 5 (PDE5) inhibitor with an IC₅₀ of 3.6 nM and prevents degradation of cyclic guanosine monophosphate (cGMP).

HY-100650

Carbodenafil	Others	Others
Carbodenafil is a Sildenafil (UK-92480) related compound found in health foods. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM.

HY-108045

Lodenafil carbonate	Phosphodiesterase (PDE)	Endocrinology
Lodenafil carbonate, a dimer that acts as a prodrug delivering Lodenafil in vivo, is an orally active phosphodiesterase type 5 (PDE5) inhibitor for the treatment of erectile dysfunction (ED).

HY-P1164

Urotensin II (114-124), human	Urotensin Receptor	Cardiovascular Disease
Urotensin II (114-124), human, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14.

HY-P1144

Oxyntomodulin
Glucagon Receptor Metabolic Disease

Oxyntomodulin, a 37-amino acid peptide hormone, is a glucagon-like peptide 1 (GLP-1) receptor agonist.

HY-W007970

H-Phe-Phe-OH	Endogenous Metabolite	Neurological Disease
H-Phe-Phe-OH is a peptide made of two phenylalanine molecules; Phenylalanine is an essential amino acid and the precursor for the amino acid tyrosine.

HY-P1164A

Urotensin II (114-124), human TFA	Urotensin Receptor	Cardiovascular Disease
Urotensin II (114-124), human TFA, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14.

HY-P1127

Galanin (1-30), human	Neuropeptide Y Receptor	Neurological Disease Endocrinology
Galanin (1-30), human is a 30-amino acid neuropeptide, and acts as an agonist of GalR1 and GalR2 receptors, with K_is of both 1 nM.

HY-P1144A

Oxyntomodulin TFA
Glucagon Receptor Metabolic Disease

Oxyntomodulin TFA, a 37-amino acid peptide hormone, is a glucagon-like peptide 1 (GLP-1) receptor agonist.

HY-90009

Nortadalafil Demethyl Tadalafil	Phosphodiesterase (PDE)	Cardiovascular Disease
Nortadalafil is demethyl Tadalafil, which is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) under the name Cialis; and under the name Adcirca for the treatment of pulmonary arterial hypertension.

HY-128593

TPN171	Phosphodiesterase (PDE)	Cardiovascular Disease
TPN171 is a potent, selective and oral bioavailable inhibitor of phosphodiesterase type 5 (PDE5) with an IC₅₀ of 0.62 nM, being developed for the treatment of pulmonary arterial hypertension (PAH).

HY-11070

MK-0952	Phosphodiesterase (PDE)	Neurological Disease
MK-0952 is a selective and orally active *PDE4* inhibitor, with an IC₅₀ of 0.53 nM. MK-0952 has the potential for Alzheimer’s disease study.

HY-108619

Gisadenafil besylate UK 369003-26	Phosphodiesterase (PDE)	Neurological Disease
Gisadenafil besylate (UK 369003-26) is a specific, orally active phosphodiesterase 5 (PDE5) inhibitor with an IC₅₀ of 3.6 nM and prevents degradation of cyclic guanosine monophosphate (cGMP).

HY-W040222

m-PEG11-Amine
ADC Linker Cancer

m-PEG11-Amino is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-P0191

Charybdotoxin	Potassium Channel	Inflammation/Immunology
Charybdotoxin, a 37-amino acid peptide isolated from venom of the scorpion Leiurus quinquestriatus var. hebraeus, is a K⁺ channel blocker.

HY-N0717A

D-Valine	Endogenous Metabolite	Metabolic Disease
D-Valine is the enantiomer of L-Valine (HY-N0717). L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid.

HY-P0191A

Charybdotoxin TFA	Potassium Channel	Inflammation/Immunology
Charybdotoxin TFA, a 37-amino acid peptide isolated from venom of the scorpion Leiurus quinquestriatus var. hebraeus, is a K⁺ channel blocker.

HY-30215

(S)-Leucic acid
Endogenous Metabolite Others

(S)-Leucic acid is an amino acid metabolite.

HY-101918

DS-1040 Tosylate	Others	Cardiovascular Disease
DS-1040 Tosylate is an orally active, selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) with IC₅₀s of 5.92 nM and 8.01 nM for human and rat TAFIa. DS-1040 Tosylate is a fibrinolysis enhancer for thromboembolic diseases.

HY-18728

STF-31
GLUT Autophagy Cancer

STF-31 is a selective inhibitor of glucose transporter 1 (GLUT1), with an IC₅₀ of 1μM^[1][2].
HY-P0324

Parasin I
Bacterial Infection

Parasin I is a 19-amino acid histone H2A-derived peptide isolated from the skin of the catfish, and shows antimicrobial activity.

HY-N0666B

*Aspartic acid* calcium** Calcium L-aspartate	Others	Cardiovascular Disease
Aspartic acid calcium (Calcium L-aspartate) is a chelate where calcium is attached to an amino acid naming L-Aspartic acid. L-Aspartic acid is an amino acid and serves as a building block for proteins in the body.

HY-113079

Argininic acid
Endogenous Metabolite Metabolic Disease

Argininic acid is an α-amino acid that is used in the biosynthesis of proteins.

HY-W018678

8-Aminooctanoic acid	Others	Metabolic Disease
8-Aminooctanoic acid is an omega-amino fatty acid that is octanoic acid which carries an amino group at position 8. 8-aminooctanoic acid has a role as a human metabolite.

HY-P0324A

Parasin I TFA
Bacterial Infection

Parasin I (TFA) is a 19-amino acid histone H2A-derived peptide isolated from the skin of the catfish, and shows antimicrobial activity.
HY-B0030

D-Cycloserine
Bacterial Antibiotic Infection

D-Cycloserine is an analog of the amino acid D-alanine.
HY-B0137A

Prilocaine hydrochloride
Na+/K+ ATPase Neurological Disease

Prilocaine hydrochloride is an amino amide type compound that used for anesthesia.
HY-B0137

Prilocaine
Na+/K+ ATPase Others

Prilocaine is an amino amide type compound that used for anesthesia.
HY-B0342

Meglumine
Methylglucamine; Meglumin; Methylglucamin
Others Others

Meglumine is an amino sugar derived from sorbitol.
HY-113426

Nepsilon-Acetyl-L-lysine
Endogenous Metabolite Others

Nepsilon-Acetyl-L-lysine is a derivative of the amino acid lysine.
HY-131112

N-Pivaloyl-L-tyrosine
Others Others

N-Pivaloyl-L-tyrosine is an N-pivaloyl amino acid ester.

HY-P1363

β-Amyloid (1-42), human TFA Amyloid β-Peptide (1-42) (human) TFA	Amyloid-β	Neurological Disease
β-Amyloid (1-42), human TFA (Amyloid β-Peptide (1-42) (human) TFA) is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.

HY-120944

BAY-7598	MMP	Inflammation/Immunology
BAY-7598 is a potent, orally bioavailable, and selective MMP12 inhibitor probe with IC₅₀s of 0.085, 0.67 and 1.1 nM for human MMP12, murine MMP12, and rat MMP12, respectively.

HY-15583

Auristatin F	Microtubule/Tubulin ADC Cytotoxin	Cancer
Auristatin F is a potent cytotoxin. Auristatin F, a potent microtubule inhibitor and vascular damaging agent (VDA), can be used in antibody-drug conjugates (ADC).

HY-104011

L-Pyrrolysine
Others Others

L-Pyrrolysine is the 22nd genetically encoded amino acid.
HY-B2236

DL-Lysine
(±)-2,6-DiAminocaproic acid
Others Others

DL-Lysine (Lysine) is an α-amino acid that is used in the biosynthesis of proteins.
HY-W010040

4-Hydroxyphenylpyruvic acid
Endogenous Metabolite Metabolic Disease

4-Hydroxyphenylpyruvic acid is an intermediate in the metabolism of the amino acid phenylalanine.
HY-113227

Oxoadipic acid
Endogenous Metabolite Metabolic Disease

Oxoadipic acid is a key metabolite of the essential amino acids tryptophan and lysine.
HY-W050026

Phenylacetylglutamine
NSC 203800; Phenylacetyl-L-glutamine
Endogenous Metabolite Others

Phenylacetylglutamine is a colonic microbial metabolite from amino acid fermentation.
HY-N2309

Kainic acid
Others Neurological Disease

Kainic acid is a potent agonist at excitatory amino acid receptor subtypes in the CNS.
HY-B0931

Citiolone
Others Others

Citiolone is a derivative of the amino acid cysteine, used in liver therapy.

HY-B0764A

Bucladesine calcium Dibutyryl cAMP calcium salt; DBcAMP calcium salt	PKA Phosphodiesterase (PDE) Apoptosis	Others
Bucladesine calcium salt (Dibutyryl-cAMP calcium salt;DC2797 calcium salt) is a cell-permeable cyclic AMP (cAMP) analog and selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine calcium salt acts as a phosphodiesterase (PDE) inhibitor.

HY-W009749

L-Cystathionine
Endogenous Metabolite Others

L-Cystathionine is a key nonprotein amino acid related to metabolic conditions.
HY-B0405A

Bupivacaine hydrochloride
Ribosomal S6 Kinase (RSK) Neurological Disease

Bupivacaine Hydrochloride is a local anaesthetic drug belonging to the amino amide group.

HY-P1348

GLP-1 moiety from Dulaglutide	Glucagon Receptor	Metabolic Disease
GLP-1 moiety from Dulaglutide is a 31-amino acid fragment of Dulaglutide which is a glucagon-like peptide 1 receptor (GLP-1) agonist, extracted from patent US 20160369010 A1.

HY-P1362

β-Amyloid (42-1), human Amyloid β Peptide (42-1)(human)	Amyloid-β	Neurological Disease
β-Amyloid (42-1), human is the inactive form of Amyloid β Peptide (1-42). Amyloid β Peptide (42-1) is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.

HY-P1537

Pancreatic Polypeptide, bovine	Neuropeptide Y Receptor	Metabolic Disease Endocrinology
Pancreatic Polypeptide, bovine, a 36-amino acid, straight chain polypeptide derived primarily from the pancreas, inhibits secretin- and cholecystokinin-stimulated pancreatic secretion; Pancreatic Polypeptide, bovine acts as an agonist of NPY receptor, with high affinity at NPYR4.

HY-Y1139

Pimelic acid Heptanedioic acid; 1,5-Pentanedicarboxylic acid; 1,7-Heptanedioic acid	Endogenous Metabolite	Metabolic Disease
Pimelic acid is the organic compound and its derivatives are involved in the biosynthesis of the amino acid called lysine.

HY-Y0127

D(-)-2-Aminobutyric acid
Endogenous Metabolite Others

D(-)-2-Aminobutyric acid is a substrate of D-amino acid oxidase.
HY-101949

LTX-401 dihydrochloride
Others Inflammation/Immunology

LTX-401, an oncolytic amino acid derivative, targets the Golgi apparatus.

HY-Y0511

N-Methylsarcosine Dimethylglycine; DMG; N,N-Dimethylglycine	Endogenous Metabolite	Others
N-Methylsarcosine is an amino acid building block for protein, found in a small amount in the body.

HY-100496

Nucleocidin 4'-Fluoro-5'-O-sulfamoyladenosine; NSC 521007	Bacterial	Infection
Nucleocidin is an antitrypanosomal antibiotic, inhibiting the transfer of labeled amino acid from S-RNA to protein.

HY-N6256

Ilexsaponin B2	Phosphodiesterase (PDE)	Cardiovascular Disease
Ilexsaponin B2 is a saponin isolated from the root of Ilex pubescens Hook. et Arn. Ilexsaponin B2 is a potent phosphodiesterase 5 (PDE5) and PDEI inhibitor with IC₅₀ values of 48.8 μM and 477.5 μM, respectively.

HY-P1235A

Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate	Endothelin Receptor	Cardiovascular Disease Endocrinology
Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. ANP (1-28) inhibits endothelin-1 secretion in a dose-dependent way.

HY-122470

Stampidine	Reverse Transcriptase HIV	Infection
Stampidine is a nucleoside reverse transcriptase inhibitor (NRTI) with potent and broad-spectrum anti-HIV activity. Stampidine inhibits the laboratory HIV-1 strain HTLV_IIIB (B-envelope subtype) and primary clinical isolates with IC₅₀s of 1 nM and 2 nM, respectively. Stampidine also inhibits NRTI-resistant primary clinical isolates and NNRTI-resistant clinical isolates with IC₅₀s of 8.7 nM and 11.2 nM, respectively.

HY-P1895

β-Amyloid (33-40)
Amyloid-β Neurological Disease

β-Amyloid (33-40) is a peptide consisting of amino acid of 33 to 40 of beta amyloid protein.
HY-Y0337

L-Cysteine
Endogenous Metabolite Ferroptosis Metabolic Disease

L-Cysteine is a thiol-containing non-essential amino acid that is oxidized to form cystine.
HY-N0666

L-Aspartic acid
Endogenous Metabolite Cardiovascular Disease

L-Aspartic acid is is an amino acid, shown to be a suitable prodrug for colon-specific drug deliverly.
HY-P1595

CREBtide
PKA Metabolic Disease

CREBtide, a synthetic 13 amino acid peptide, has been reported as a PKA substrate.
HY-P1818

Neuropeptide Y (22-36)
Neuropeptide Y Receptor Neurological Disease Endocrinology

Neuropeptide Y (22-36), a 15 amino acid peptide, is a fragment of Neuropeptide Y.

HY-N0832

L-Histidine	Mitochondrial Metabolism Endogenous Metabolite	Metabolic Disease Inflammation/Immunology Neurological Disease
L-Histidine is an essential amino acid for infants. L-Histidine is an inhibitor of mitochondrial glutamine transport.

HY-Y0252

L-Proline
Endogenous Metabolite Others

L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins.
HY-P1903

β-Amyloid (35-42)
Amyloid-β Neurological Disease

β-Amyloid (35-42) is a peptide consisting of amino acid of 35 to 42 of beta amyloid protein.
HY-113380

(S)-b-aminoisobutyric acid
Endogenous Metabolite Metabolic Disease

(S)-b-aminoisobutyric acid is a non-protein amino acid originating from the catabolism of thymine and valine.
HY-113232

3-Methylcrotonylglycine
Endogenous Metabolite Metabolic Disease

3-Methylcrotonylglycine is an acyl glycine, a normal amino acid metabolite found in urine.

HY-108540

LAT1-IN-1 BCH	Apoptosis	Cancer
LAT1-IN-1 (BCH) is a selective and competitive inhibitor of *large neutral amino* acid transporter 1 (LAT1)** significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis.

HY-P1841

Glucagon-Like Peptide (GLP) II, human	Endogenous Metabolite	Metabolic Disease
Glucagon-Like Peptide (GLP) II, human is a 33-amino acid peptide derived from the C-terminal of proglucagon and mainly produced by the intestinal L cells. Glucagon-Like Peptide (GLP) II, human stimulates intestinal mucosal growth and decreases apoptosis of enterocytes .

HY-P0122

iRGD peptide c(CRGDKGPDC)	Integrin	Cancer
iRGD peptide is a 9-amino acid cyclic peptide, triggers tissue penetration of drugs by first binding to av integrins, then proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1, and has tumor-targeting and tumor-penetrating properties.

HY-P1179

Guanylin(human)	Guanylate Cyclase Endogenous Metabolite	Cancer Endocrinology
Guanylin(human), a 15-amino acid peptide, is an endogenous intestinal guanylate cyclase activator. Guanylin(human) is mainly found in gastrointestinal tract which regulates electrolytead water transport in intestinal and renal epithelia through cyclic GMP-dependent mechanism.

HY-P1271

Catestatin	nAChR	Cardiovascular Disease
Catestatin is a 21-amino acid residue, cationic and hydrophobic peptide. Catestatin is an endogenous peptide that regulates cardiac function and blood pressure. Catestatin is a non-competitive nicotinic antagonist acting through nicotinic acetylcholine receptors (nAChRs) to inhibit catecholamine release.

HY-101877

Statine (3S,4S)-Statine; (S,S)-Statine	Others	Endocrinology
Statine is an unusual amino acid that occurs twice in the sequence of pepstatin, a protease inhibitor that is active against pepsin and other acid proteases.

HY-N0454

DL-Arginine
Others Cardiovascular Disease

DL-Arginine is used in physicochemical analysis of amino acid complexation dynamics and crystal structure formations.

HY-B1000

Selenomethionine Seleno-DL-methionine; DL-Selenomethionine	Autophagy Endogenous Metabolite	Cancer
Selenomethionine is a naturally occurring amino acid containing selenium, is a common natural food source of selenium.

HY-101409

O-Acetylserine
O-Acetyl-L-serine
Endogenous Metabolite Others

O-Acetylserine (O-Acetyl-L-serine) is an intermediate in the biosynthesis of the amino acid cysteine in bacteria and plants.
HY-113080

N-Acetylornithine
Endogenous Metabolite Others

N-Acetylornithine is an intermediate in the enzymatic biosynthesis of the amino acid L-arginine from L-glutamate.
HY-N0473

L-Tyrosine
Endogenous Metabolite Neurological Disease

L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
HY-B0007

Baclofen
GABA Receptor Neurological Disease

Baclofen is a gamma-amino-butyric acid (GABA) derivative used as a skeletal muscle relaxant.
HY-P1601

Neuropeptide Y(29-64)
Neuropeptide Y Receptor Neurological Disease Endocrinology

Neuropeptide Y(29-64) is a 36 amino acid peptide, a fragment of Neuropeptide Y.

HY-101404

DL-Homocysteine thiolactone hydrochloride	Endogenous Metabolite	Others
DL-Homocysteine thiolactone hydrochloride is a cyclic amino acid derivative that exhibits root-growth inhibitory activity.

HY-104026

L-Kynurenine	Aryl Hydrocarbon Receptor Endogenous Metabolite	Cancer Inflammation/Immunology Neurological Disease Cardiovascular Disease
L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist.

HY-N0130

Shikimic acid
Endogenous Metabolite Others

Shikimic acid is a key metabolic intermediate of the aromatic amino acid biosynthesis pathway, found in microbes and plants.
HY-W002292

L-Homoserine
Endogenous Metabolite Others

L-Homoserine is a non - protein amino acid, which is an important biosynthetic intermediate of threonine, methionine and lysine.
HY-N0326

L-Methionine
Endogenous Metabolite Others

L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.

HY-P1179A

Guanylin(human) TFA	Guanylate Cyclase Endogenous Metabolite
Guanylin(human) TFA, a 15-amino acid peptide, is an endogenous intestinal guanylate cyclase activator. Guanylin(human) TFA is mainly found in gastrointestinal tract which regulates electrolytead water transport in intestinal and renal epithelia through cyclic GMP-dependent mechanism.

HY-19672

Lirimilast BAY 19-8004	Phosphodiesterase (PDE)	Inflammation/Immunology
Lirimilast (BAY 19-8004) is a potent, selective and orally active phosphodiesterase-4 (PDE4) inhibitor with an IC₅₀ value of 49 nM. Lirimilast can be used for the treatment of asthma or chronic obstructive pulmonary disease (COPD). Lirimilast has potently anti-inflammatory properties.

HY-B0764

Bucladesine sodium Dibutyryl cAMP sodium salt; DBcAMP sodium salt	PKA Phosphodiesterase (PDE)	Inflammation/Immunology
Bucladesine sodium salt (Dibutyryl-cAMP sodium salt) is a stabilized cyclic AMP (cAMP) analog and a selective PKA activator. Bucladesine sodium salt raises the intracellular levels of cAMP. Bucladesine sodium salt is also a phosphodiesterase (PDE) inhibitor. Bucladesine sodium salt has anti-inflammatory activity and can be used for impaired wound healing.

HY-101708

N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea	Others	Neurological Disease
N-[(1R)-4-[(Aminoiminomethyl)amino]-1-[[[(1R)-1-(4-hydroxyphenyl)ethyl]amino]carbonyl]butyl]-α-phenylbenzeneacetamide is an anticonvulsant agent with potential for the treatment of generalized tonic-clonic and partial seizures.

HY-P1593

Mini Gastrin I, human
Cholecystokinin Receptor Cancer Endocrinology

Mini Gastrin I, human is a shorter version of human gastrin, consists of amino acids 5-17 of the parent peptide.
HY-P1850

β-Amyloid (1-20)
Amyloid-β Neurological Disease

β-Amyloid (1-20) consists of amino acids 1 to 20 of beta amyloid protein.
HY-114158

Pronase E
Pronase
Others Others

Pronase E is a mixture of proteolytic enzymes that is obtained from Streptomyces griseus and could digest protein into individual amino acids.
HY-N0658A

DL-Threonine
Others Inflammation/Immunology

DL-Threonine, an essential amino acid, has the potential to treat hypostatic leg ulceration.

HY-N0390

L-Glutamine L-Glutamic acid 5-amide	mGluR Endogenous Metabolite Ferroptosis	Metabolic Disease
L-Glutamine is a non-essential amino acid present abundantly throughout the body and is involved in gastrointestinal disorders.

HY-N0394

L-Cystine
Endogenous Metabolite Ferroptosis Others

L-Cystine is an amino acid and intracellular thiol, which plays a critical role in the regulation of cellular processes.

HY-N0230

β-Alanine 2-Carboxyethylamine; 3-Aminopropanoic acid	Endogenous Metabolite	Metabolic Disease
β-Alanine is a non-essential amino acid that is shown to be metabolized into carnosine, which functions as an intracellular buffer.

HY-113379

2,3-Diaminopropionic acid
Endogenous Metabolite Others

2, 3-Diaminopropionic acid is a metabolite of b-oxalyl-L-a, b-diaminopropionic acid a neurotoxic amino acid (ODAP).
HY-W010388

Creatine
Endogenous Metabolite Metabolic Disease

Creatine, an endogenous amino acid derivative, plays an important role in cellular energy, especially in muscle and brain.

HY-128676

N-ε-propargyloxycarbonyl-L-lysine hydrochloride H-L-Lys(Poc)-OH (hydrochloride)	Others	Cancer
N-ε-propargyloxycarbonyl-L-lysine hydrochloride is a modified amino acid (L-lysine) for cancer therapy development.

HY-P1235

Carperitide Atrial Natriuretic Peptide (ANP) (1-28), human, porcine	Endothelin Receptor	Cardiovascular Disease Endocrinology
Carperitide (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine) is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. Carperitide (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine) inhibits endothelin-1 secretion in a dose-dependent way.

HY-P1271A

Catestatin TFA	nAChR	Cardiovascular Disease
Catestatin TFA is a 21-amino acid residue, cationic and hydrophobic peptide. Catestatin TFA is an endogenous peptide that regulates cardiac function and blood pressure. Catestatin TFA is a non-competitive nicotinic antagonist acting through nicotinic acetylcholine receptors (nAChRs) to inhibit catecholamine release.

HY-131146

AMOZ
3-Amino-5-morpholinomethyl-2-oxazolidone
Antibiotic Infection

AMOZ, a tissue bound metabolite of Furaltadone, Furaltadone is a synthetic nitrofuran antibiotic widely used

HY-14602

Tramiprosate Homotaurine; 3-Amino-1-propanesulfonic acid	Amyloid-β	Cancer
Tramiprosate is a small, orally-administered compound that binds to soluble Aβ and reduces amyloid aggregation and subsequent deposition target: Aβ In vitro: Tramiprosate provides neuroprotection against Aβ-induced neurotoxicity in neuronal and mouse organotypic hippocampal cultures, and reverses Aβ-induced long-term potentiation (LTP) inhibition in rat hippocampus, in part, through activation of β-aminobutyric acid A (GABA-A) receptors.

HY-P0316

TP508	Thrombin NO Synthase	Cardiovascular Disease
TP508 is a 23-amino acid nonproteolytic thrombin peptide that represents a portion of the receptor-binding domain of thrombin molecule. TP508 activates endothelial NO synthase (eNOS) and stimulates production of NO in human endothelial cells. TP508 activates endothelial cells and stem cells to revascularize and regenerate tissues.

HY-11007

GNF-2
Bcr-Abl SARS-CoV Cancer

GNF-2 is a highly selective, allosteric, non-ATP competitive inhibitor of Bcr-Abl. GNF-2 inhibits Ba/F3.p210 proliferation with an IC₅₀ of 138 nM .

HY-107373

β-Chloro-L-alanine L-β-Chloroalanine	Bacterial	Infection
β-Chloro-L-alanine is a bacteriostatic amino acid analog which inhibits a number of enzymes, including threonine deaminase and alanine racemase.

HY-112619

TES-991
Others Metabolic Disease

TES-991 is a potent and selective human α‑Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD) inhibitor, with an IC₅₀ of 3 nM.

HY-N0623

L-Tryptophan Tryptophan; Tryptophane	Endogenous Metabolite	Metabolic Disease
L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3.

HY-111412

DAAO inhibitor-1
Others Neurological Disease

DAAO inhibitor-1 is a potent D-amino acid oxidase (DAAO) inhibitor with an IC₅₀ of 0.12 μM.

HY-16714

4-Azido-L-phenylalanine p-Azidophenylalanine; p-Azido-L-phenylalanine	Others	Others
4-Azido-L-phenylalanine is an unnatural amino acid, which is used as an effective vibrational reporter of local protein environments.

HY-16714A

4-Azido-L-phenylalanine hydrochloride p-Azidophenylalanine hydrochloride; p-Azido-L-phenylalanine hydrochloride	Others	Others
4-Azido-L-phenylalanine hydrochloride is an unnatural amino acid, which is used as an effective vibrational reporter of local protein environments.

HY-P1593A

Mini Gastrin I, human TFA	Cholecystokinin Receptor	Cancer Endocrinology
Mini Gastrin I, human (TFA) is a shorter version of human gastrin, consists of amino acids 5-17 of the parent peptide.

HY-P1531

γ-1-Melanocyte Stimulating Hormone (MSH), amide	Melanocortin Receptor	Metabolic Disease Endocrinology
γ-1-Melanocyte Stimulating Hormone (MSH), amide is a 11-amino acid peptide. γ-1-Melanocyte Stimulating Hormone (MSH) regulates sodium (Na⁺) balance and blood pressure through activation of the melanocortin receptor 3 (MC3-R).

HY-P1565

Transdermal Peptide TD 1 (peptide)	Na+/K+ ATPase	Inflammation/Immunology
Transdermal Peptide (TD 1 peptide) is a 11-amino acid peptide, binds toNa⁺/K⁺-ATPase beta-subunit (ATP1B1), and mainly interacts with the C-terminus of ATP1B1. Transdermal Peptide can enhance the transdermal delivery of many macromolecules.

HY-122207

Erythromycin A enol ether
Others Infection

Erythromycin A enol ether is an acidic degradation product of Erythromycin A (macrolide antibiotic) and has no antibacterial effect.

HY-B1816

Zaprinast M&B 22948	Phosphodiesterase (PDE)	Neurological Disease Cardiovascular Disease Endocrinology
Zaprinast (M&B 22948) is an inhibitor of cGMP-selective *Phosphodiesterases(PDEs). Zaprinast is a G protein-coupled receptor (GPR) 35* agonist which activates rat GPR35 strongly and activates human GPR35 moderately. Zaprinast reduces vessel remodeling through antiproliferative and proapoptotic effects.

HY-W017018

L-Ornithine hydrochloride	Endogenous Metabolite	Metabolic Disease
L-Ornithine hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen.

HY-N0667

L-Asparagine (-)-Asparagine; Asn; Asparamide	Endogenous Metabolite	Neurological Disease
L-Asparagine ((-)-Asparagine) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-B0404A

Benserazide hydrochloride Serazide; Ro 4-4602	Others	Neurological Disease
Benserazide hydrochloride (Serazide) is commonly used in Parkinson's disease and is an inhibitor of peripheral aromatic L-amino acid decarboxylase (AADC).

HY-10914

UCPH-101
Others Neurological Disease

UCPH-101 is an excitatory amino acid transporter subtype 1 (EAAT1) inhibitor with an IC₅₀ of 0.66 μM.
HY-N0666C

L-Aspartic aicd sodium
Sodium L-aspartate
Endogenous Metabolite Others

L-Aspartic aicd sodium is is an amino acid, shown to be a suitable prodrug for colon-specific drug deliverly.

HY-107383

Tetrahydrobiopterin Sapropterin	NO Synthase Endogenous Metabolite	Inflammation/Immunology
Tetrahydrobiopterin is a cofactor of the *aromatic amino* acid hydroxylases enzymes and also acts as an essential cofactor for all nitric oxide synthase** (NOS) isoforms.

HY-N0486

L-Leucine
mTOR Metabolic Disease

L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.

HY-P1484

Bradykinin (1-7) Bradykinin Fragment 1-7	Bradykinin Receptor	Cardiovascular Disease Endocrinology
Bradykinin (1-7) is an amino-truncated Bradykinin peptide. Bradykinin (1-7) is a metabolite of Bradykinin, cleaved by endopeptidase.

HY-100803

Hypotaurine 2-Aminoethanesulfinic acid	Endogenous Metabolite	Neurological Disease
Hypotaurine (2-aminoethanesulfinic acid), an intermediate in taurine biosynthesis from cysteine in astrocytes, is an endogenous inhibitory amino acid of the glycine receptor.

HY-N0658

L-Threonine
Endogenous Metabolite Others

L-Threonine is a natural amino acid, can be produced by microbial fermentation, and is used in food, medicine, or feed.

HY-P0173A

Chlorotoxin	Chloride Channel	Cancer
Chlorotoxin is a 36 amino-acid peptide from the venom of the Israeli scorpion Leiurus quinquestriatus with anticancer activity. Chlorotoxin is a chloride channel blocker.

HY-112251

D-Lin-MC3-DMA
Others Cancer

D-Lin-MC3-DMA, an ionizable amino lipid, is a potent siRNA delivery vehicle.

HY-P0316A

TP508 TFA	Thrombin NO Synthase	Cardiovascular Disease
TP508 TFA is a 23-amino acid nonproteolytic thrombin peptide that represents a portion of the receptor-binding domain of thrombin molecule. TP508 TFA activates endothelial NO synthase (eNOS) and stimulates production of NO in human endothelial cells. TP508 TFA activates endothelial cells and stem cells to revascularize and regenerate tissues.

HY-P1565A

Transdermal Peptide TFA TD 1 (peptide) (TFA)	Na+/K+ ATPase	Others
Transdermal Peptide TFA (TD 1 peptide TFA) is a 11-amino acid peptide, binds to Na⁺/K⁺-ATPase beta-subunit (ATP1B1), and mainly interacts with the C-terminus of ATP1B1. Transdermal Peptide TFA can enhance the transdermal delivery of many macromolecules.

HY-19026

Siguazodan SKF 94836	Phosphodiesterase (PDE)	Cardiovascular Disease
Siguazodan (SKF 94836) is a potent, selective and orally active phosphodiesterase III (PDE-III) inhibitor with an IC₅₀ of 117 nM. Siguazodan increases cAMP accumulation in intact platelets with an EC₅₀ of 18.88 μM. Siguazodan also inhibits phenylephrine-induced 5-HT release with an IC₅₀ value of 4.2 μM.

HY-W017462

Creatine monohydrate	Endogenous Metabolite	Metabolic Disease
Creatine monohydrate, an endogenous amino acid derivative, plays an important role in cellular energy, especially in muscle and brain.

HY-W016443

L-m-Tyrosine	Others	Inflammation/Immunology Neurological Disease
L-m-Tyrosine is an unnatural amino acid, that has potential in the research of Parkinsons disease, Alzheimers disease, and arthritis.

HY-W013494

L-Carnosine	Endogenous Metabolite	Metabolic Disease
L-Carnosine is a dipeptide of the amino acids beta-alanine and histidine and has the potential to suppress many of the biochemical changes that accompany aging.

HY-P1534

Adrenomedullin (1-50), rat	CGRP Receptor	Cardiovascular Disease
Adrenomedullin (1-50), rat is a 50 amino acid peptide, which induces a selective arterial vasodilation via activation of CGRP1 receptor.

HY-W016823

Tyramine hydrochloride	Endogenous Metabolite	Cardiovascular Disease
Tyramine hydrochloride is an amino acid that helps regulate blood pressure. Tyramine hydrochloride occurs naturally in the body, and it's found in certain foods.

HY-P1490

Bradykinin (2-9) Des-Arg1-bradykinin	Bradykinin Receptor	Cardiovascular Disease Endocrinology
Bradykinin (2-9) is an amino-truncated Bradykinin peptide. Bradykinin (2-9) is a metabolite of Bradykinin, cleaved by Aminopeptidase P.

HY-W007606

Tyramine	Endogenous Metabolite	Cardiovascular Disease
Tyramine is an amino acid that helps regulate blood pressure. Tyramine occurs naturally in the body, and it's found in certain foods.

HY-N0384

Homovanillic acid Vanilacetic acid	Endogenous Metabolite	Metabolic Disease
Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.

HY-111365

TES-1025
Others Metabolic Disease

TES-1025 is a potent and selective human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) inhibitor with an IC₅₀ of 13 nM.

HY-N0650

L-Serine (-)-Serine; (S)-Serine	Endogenous Metabolite	Cancer
L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-90009C

ent-Tadalafil ent-IC-351	Phosphodiesterase (PDE)	Cancer
ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS). compound (6R,12aS) is a potent *PDE5* inhibitor with an IC₅₀ of 0.090 μM, while ent-Tadalafil is inactive at concentrations up to 10 µM.

HY-P1365

α-Conotoxin MII α-CTxMII	nAChR	Neurological Disease
α-Conotoxin MII (α-CTxMII), a 16-amino acid peptide from the venom of the marine snail Conus magus, potently blocks nicotinic acetylcholine receptors (nAChRs) composed of α3β2 subunits, with an IC₅₀ of 0.5 nM. α-Conotoxin MII (α-CTxMII) potently blocks β3-containing neuronal nicotinic receptors .

HY-B1295

*Citric acid* trilithium salt tetrahydrate** Lithium citrate tribasic tetrahydrate; Trilithium citrate tetrahydrate	Bacterial	Infection
Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) is a pharmaceutical and construction material, used in HPLC gradient elution for quantitative amino acid analysis.

HY-N0391

L-Citrulline	Endogenous Metabolite	Others
L-Citrulline is an amino acid derived from ornithine in the catabolism of proline or glutamine and glutamate, or from l-arginine via arginine-citrulline pathway.

HY-W012382

N-Acetyl-L-tyrosine	Endogenous Metabolite	Metabolic Disease
N-Acetyl-L-tyrosine originates from tyrosine through an AA acetylase, is associated with aromatic L-amino acid decarboxylase deficiency and tyrosinemia I.

HY-P1469

Bradykinin (1-6)	Bradykinin Receptor	Cardiovascular Disease Endocrinology
Bradykinin (1-6) is an amino-truncated Bradykinin peptide. Bradykinin (1-6) is a stable metabolite of Bradykinin, cleaved by carboxypeptidase Y (CPY).

HY-111149

PS372424
CXCR Inflammation/Immunology Endocrinology

PS372424, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity.

HY-I1060

L-Alloisoleucine (3R)-LS-Isoleucine; L-Allo-isoleucine	Endogenous Metabolite	Others
L-Alloisoleucine is a branched chain amino acid and is a stereo-isomer of L-isoleucine. L-Alloisoleucine is a common constituent of human plasma (albeit at low levels).

HY-135746

OR-1896	Potassium Channel Phosphodiesterase (PDE) Drug Metabolite	Cardiovascular Disease
OR-1896 is an active long-lived metabolite of Levosimendan. OR-1896 is a highly selective *phosphodiesterase (PDE) III* isoform inhibitor and a powerful vasodilator. OR-1896 can open ATP-sensitive K⁺ channels and has Ca²⁺-sensitizing effect. OR-1896 mitigates cardiomyocyte apoptosis, cardiac remodeling and myocardial inflammation.

HY-13443

Exendin-4
Exenatide
Glucagon Receptor Metabolic Disease

Exendin-4 (Exenatide), a 39 amino acid peptide, is a long-acting glucagon-like peptide-1 receptor agonist with an IC₅₀ of 3.22 nM.

HY-N0229

L-Alanine L-2-Aminopropionic acid	Endogenous Metabolite	Metabolic Disease Neurological Disease
L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.

HY-N1477

Dencichine Dencichin; ODAP	HIF/HIF Prolyl-Hydroxylase	Neurological Disease
Dencichin is a non-protein amino acid originally extracted from Panax notoginseng, and can inhibit HIF-prolyl hydroxylase-2 (PHD-2) activity.

HY-103228

GYKI53655 hydrochloride
iGluR Neurological Disease

GYKI53655 hydrochloride is an α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) antagonist.

HY-P1462

Calcitonin Gene Related Peptide (CGRP) (83-119), rat	CGRP Receptor	Neurological Disease
Calcitonin Gene Related Peptide (CGRP) (83-119), rat is a 37 amino acid calcitonin family of neuropeptide, acts through calcitonin receptor-like receptor (CRLR).

HY-13443A

Exendin-4 Acetate Exenatide acetate	Glucagon Receptor	Metabolic Disease
Exendin-4 Acetate (Exenatide acetate), a 39 amino acid peptide, is a long-acting glucagon-like peptide-1 receptor agonist with an IC₅₀ of 3.22 nM.

HY-N3894

Ferulamide
nAChR Neurological Disease

Ferulamide is a Ferulic acid derivative isolated from Portulaca oleracea L. with anticholinesterase activities.

HY-14850

Sograzepide Netazepide; YF 476; YM-220	Cholecystokinin Receptor	Metabolic Disease Endocrinology
Sograzepide (Netazepide; YF 476; YM-220) is an extremely potent , highly selective and orally active Gastrin/CCK-B antagonist with an IC₅₀ value of 0.1 nM, has inhibitory effect on Gastrin/CCK-A activity with an IC₅₀ of 502 nM. Sograzepide (Netazepide; YF 476; YM-220) replaces the specific binding of [125I]CCK-8 to the rat brain, cloned canine and cloned human Gastrin/CCK-B receptors, with K_i values of 0.068, 0.62 and 0.19 nM, respectively.

HY-Y1362

Ethyl pyruvate
Others Inflammation/Immunology

Ethyl pyruvate is a simple derivative of the endogenous metabolite, pyruvic acid. Ethyl pyruvate is an anti-inflammatory agent.

HY-W015410

Disodium succinate	Others	Metabolic Disease
Disodium succinate is the disodium salt of Succinic acid. Succinic acid is an intermediate product of the tricarboxylic acid cycle, as well as one of fermentation products of anaerobic metabolism.

HY-N3010

Salviaflaside
Others Inflammation/Immunology

Salviaflaside is a main bioactive component of Spica Prunellae.

HY-76547

p-Toluic acid 4-Methylbenzoic acid	Endogenous Metabolite	Others
p-Toluic acid (4-Methylbenzoic acid) is a substituted benzoic acid and can be used as an intermediate for the synthesis of para-aminomethylbenzoic acid (PAMBA), p-tolunitrile, etc.

HY-W011819

Tetradecanedioic acid	Endogenous Metabolite	Metabolic Disease
Tetradecanedioic acid is an endogenous metabolite and belongs to the class of organic compounds known as long-chain fatty acids. Tetradecanedioic acid can act as a candidate biomarker for organic anion-transporting polypeptide mediated drug-drug interactions .

HY-P1365A

α-Conotoxin MII TFA α-CTxMII TFA	nAChR	Neurological Disease
α-Conotoxin MII TFA (α-CTxMII TFA), a 16-amino acid peptide from the venom of the marine snail Conus magus, potently blocks nicotinic acetylcholine receptors (nAChRs) composed of α3β2 subunits, with an IC₅₀ of 0.5 nM. α-Conotoxin MII TFA (α-CTxMII TFA) potently blocks β3-containing neuronal nicotinic receptors .

HY-P1462A

Calcitonin Gene Related Peptide (CGRP) (83-119), rat TFA	CGRP Receptor	Neurological Disease
Calcitonin Gene Related Peptide (CGRP) (83-119), rat (TFA) is a 37 amino acid calcitonin family of neuropeptide, acts through calcitonin receptor-like receptor (CRLR).

HY-W012499

N-Acetyl-L-methionine N-Acetylmethionine	Endogenous Metabolite	Metabolic Disease
N-Acetyl-L-methionine, a human metabolite, is nutritionally and metabolically equivalent to L-methionine. L-methionine is an indispensable amino acid required for normal growth and development.

HY-10935

LY450108
iGluR Neurological Disease

LY450108 is an alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor potentiator.

HY-D0885B

Phosphocreatine disodium Disodium creatine phosphate	Endogenous Metabolite	Metabolic Disease
Phosphocreatine disodium, one of organic compounds known as alpha amino acids and derivatives, is a substrate for the determination of creatine kinase and used to regenerate ATP during skeletal muscle contraction.

HY-114381

GT 949
EAAT2 Neurological Disease

GT 949 is a selective excitatory amino acid transporter-2 (EAAT2) positive allosteric modulator with an EC₅₀ of 0.26 nM.

HY-N0470

L-Lysine hydrochloride	Virus Protease	Infection Endocrinology Inflammation/Immunology Cardiovascular Disease
L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.

HY-13295

Vinpocetine Ethyl apovincaminate	Sodium Channel IKK Phosphodiesterase (PDE)	Inflammation/Immunology Neurological Disease Cardiovascular Disease Cancer
Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na⁺ channels. The IC₅₀ value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders.

HY-N2284

Sophoflavescenol	AChE Beta-secretase Phosphodiesterase (PDE)	Cancer
Sophoflavescenol is a prenylated flavonol, which shows great inhibitory activity with IC₅₀ of 0.013 μM against Phosphodiesterase 5 (PDE5), and also inhibits RLAR, HRAR, AGE, BACE1, AChE and BChE with IC₅₀s of 0.30 µM, 0.17 µM, 17.89 µg/mL, 10.98 µM, 8.37 µM and 8.21 µM, respectively.

HY-P1750

Shepherdin (79-87)	HSP Survivin	Cancer
Shepherdin (79-87) is amino acids 79 to 87 fragment of Shepherdin. Shepherdin is a peptidomimetic antagonist of the complex between Hsp90 and Survivin. Anticancer activity.

HY-P1170

N-terminally acetylated Leu-enkephalin Ac-L-Tyr-Gly-Gly-L-Phe-D-Leu-COOH	Opioid Receptor	Neurological Disease
N-terminally acetylated Leu-enkephalin is the N-terminally acetylated form of Leu-enkephalin. Leu-enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.

HY-P1749

Influenza HA (307-319)	Influenza Virus	Infection
Influenza HA (307-319) is 13 amino acids 307 to 319 fragment of Influenza HA. Influenza HA is a glycoprotein found on the surface of influenza viruses.

HY-135717

Norbiotinamine	Others	Cancer
Norbiotinamine is an alternative to biotin. Norbiotinamine can be coupled with a carboxylic group of amino acids to give inverse peptides, having the amide linkage oriented in the opposite direction.

HY-113063

3-Methyl-2-oxovaleric acid	Endogenous Metabolite	Others
3-Methyl-2-oxovaleric acid is a neurotoxin, an acidogen, and a metabotoxin, and also an abnormal metabolite that arises from the incomplete breakdown of branched-chain amino acids.

HY-135717A

Norbiotinamine hydrochloride	Others	Cancer
Norbiotinamine hydrochloride is an alternative to biotin. Norbiotinamine can be coupled with a carboxylic group of amino acids to give inverse peptides, having the amide linkage oriented in the opposite direction.

HY-W015240

N-Acetyl-L-glutamic acid	Endogenous Metabolite	Metabolic Disease
N-Acetyl-L-glutamic acid, a N-acyl-L-amino acid, is a component of animal cell culturing media. N-Acetyl-L-glutamic acid is a metabolite of Saccharomyces cerevisiae and human.

HY-N0122

5-Hydroxytryptophan 5-HTP; DL-5-Hydroxytryptophan	Endogenous Metabolite	Metabolic Disease
5-Hydroxytryptophan, a tryptophan metabolite, is a direct 5-hydroxytryptamine (5-HT) precursor and an L-aromatic amino acid decarboxylase substrate. .

HY-N6848

Acetylseneciphylline N-oxide	Others	Infection
Acetylseneciphylline N-oxide is a pyrrolizine alkaloid that is seneciphylline in which the hydroxy hydrogen is replaced by an acetyl group and the tertiary amino function is oxidised to the corresponding N-oxide.

HY-119737

Chlorsulfuron	Others	Metabolic Disease
Chlorsulfuron blocks the biosynthesis of the amino acids valine and isoleucine in plants. Chlorsulfuron completely alleviates herbicide-induced growth inhibition. The site of action of Chlorsulfuron is the enzyme acetolactate synthase.

HY-P0288

[Leu5]-Enkephalin Leu-enkephalin; Leucine enkephalin; Leucyl-enkephalin	Opioid Receptor Endogenous Metabolite	Neurological Disease
[Leu5]-Enkephalin is a pentapeptides with morphine like properties. [Leu5]-Enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.

HY-W012572

D-Histidine	Mitochondrial Metabolism	Metabolic Disease
D-Histidine is an enantiomer of L-histidine (HY-N0832). L-Histidine is an essential amino acid for infants. L-Histidine is an inhibitor of mitochondrial glutamine transport.

HY-P0199

Pancreatic Polypeptide, human Human pancreatic polypeptide	Neuropeptide Y Receptor	Metabolic Disease Endocrinology
Pancreatic Polypeptide, human is a C-terminally amidated 36 amino acid peptide, which acts as a neuropeptide Y (NPY) Y4/Y5 receptor agonist.

HY-16391

Glasdegib PF-04449913	Smo	Cancer
Glasdegib (PF-04449913) is a potent and orally bioavailable smoothened inhibitor. Glasdegib (PF-04449913) binds to human SMO (amino acids 181-787) with an IC₅₀ of 4 nM.

HY-P1755

p53 (17-26)
MDM-2/p53 Cancer

p53 (17-26) is amino acids 17 to 26 fragment of p53. p53 (17-26) is mdm-2-binding domain.

HY-W016781

D-Arginine H-D-Arg-OH	Others	Others
D-arginine (H-D-Arg-OH) is the D-isomer of arginine. Arginine is an α-amino acid that is used in the biosynthesis of proteins. D-Arginine is an inactive form of L-arginine.

HY-15072

Zonampanel YM 872	iGluR	Metabolic Disease
Zonampanel (YM 872) is a selective antagonist of the glutamate receptor subtype, α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor.

HY-103700B

(Rac)-Azide-phenylalanine	Others	Others
(Rac)-Azide-phenylalanine is a racemate of Azide-phenylalanine. Azide-phenylalanine is a phenylalanine derivative and a non-natural amino acid. Azide-phenylalanine can be site-specifically incorporated into proteins and used to label proteins.

HY-P1519B

Brain Natriuretic Peptide (1-32), rat acetate BNP (1-32), rat acetate	Angiotensin Receptor	Cardiovascular Disease
Brain Natriuretic Peptide (1-32), rat acetate (BNP (1-32), rat acetate) is a 32 amino acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of heart muscle cells (cardiomyocytes).

HY-D0885

Phosphocreatine Creatine phosphate; Creatinephosphoric acid	Endogenous Metabolite	Metabolic Disease
Phosphocreatine, primarily found in the skeletal muscles of vertebrates and one of organic compounds known as alpha amino acids and derivatives, is a substrate for the determination of creatine kinase and used to regenerate ATP during skeletal muscle contraction..

HY-133126

hDDAH-1-IN-1	Others	Cancer Inflammation/Immunology
hDDAH-1-IN-1 (compound 8a) is a potent and selective non-amino acid catalytic site inhibitor of human dimethylarginine dimethylaminohydrolase-1 (hDDAH-1), with a K_i of 18 µM.

HY-P1519

Brain Natriuretic Peptide (1-32), rat BNP (1-32), rat	Angiotensin Receptor	Cardiovascular Disease
Brain Natriuretic Peptide (1-32), rat (BNP (1-32), rat) is a 32 amino acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of heart muscle cells (cardiomyocytes).

HY-N0469

L-Lysine	Endogenous Metabolite Virus Protease	Inflammation/Immunology
L-lysine is an essential amino acid with important roles in connective tissues and carnitine synthesis, energy production, growth in children, and maintenance of immune functions.

HY-43470

3α,12β-Dihydroxycholanoic acid
Endogenous Metabolite Metabolic Disease

3α,12β-Dihydroxycholanoic acid is a bile acid that can be isolated from urine specimens of healthy humans.
HY-125686

Beesioside Q
Others Others

Beesioside Q is a oleanolic acid triterpene saponin isolated from the rhizome of Beesia calthaefolia (Maxim.) Ulbr.

HY-135801

Arachidonyl alcohol	Others	Metabolic Disease
Arachidonyl alcohol is a long-chain primary fatty alcohol. Arachidonyl alcohol is used as a substrate for the production of several ether lipids possessing beneficial functions.

HY-106579S

*Tiaprofenic acid* D3**	Others	Inflammation/Immunology
Tiaprofenic acid D3 is a deuterium labeled Tiaprofenic acid. Tiaprofenic acid is a nonsteroidal anti-inflammatory drug (NSAID) mainly used in the treatment of rheumatic diseases.

HY-129357

CCK-B Receptor Antagonist 2	Cholecystokinin Receptor	Metabolic Disease
CCK-B Receptor Antagonist 2, compound 15b, is a potent and orally active Gastrin/CCK-B antagonist with an IC₅₀ value of 0.43 nM. CCK-B Receptor Antagonist 2 also inhibits gastrin/CCK-A activity with an IC₅₀ of 1.82 μM.

HY-129467

Minerval 2-Hydroxyoleic acid; 2-OHOA	Apoptosis	Cancer
Minerval (2-Hydroxyoleic acid) is a synthetic oleic acid (OA) derivative that binds to the plasma membrane and alters lipid organization. Minerval has anti-tumor effect.

HY-113478

3β-Ursodeoxycholic acid Isoursodeoxycholic acid	Others	Metabolic Disease
3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) is a bile acid. 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) shows good tolerance and well intestinal absorption by oral adminstation. 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) can be isomerized by intestinal and hepatic enzymes to yield UDCA.

HY-135652

Hexyl gallate Hexyl 3,4,5-trihydroxybenzoate	Parasite	Infection
Hexylgallate (Hexyl 3,4,5-trihydroxybenzoate), a alkyl ester derivative of gallic acid, exhibits potent antimalarial activity against Plasmodium falciparum, with IC₅₀ of 0.11 mM.

HY-107830

Methyl cholate	Others	Metabolic Disease
Methyl Cholate is methyl ester form of Cholic acid. Cholic acid is one of the major bile acids produced by the liver, where it is synthesized from cholesterol.

HY-133126A

hDDAH-1-IN-1 TFA	Others	Cancer Inflammation/Immunology
hDDAH-1-IN-1 TFA (compound 8a) is a potent and selective non-amino acid catalytic site inhibitor of human dimethylarginine dimethylaminohydrolase-1 (hDDAH-1), with a K_i of 18 µM.

HY-D0885C

Phosphocreatine dipotassium Creatine phosphate (dipotassium); Creatinephosphoric acid (dipotassium)	Endogenous Metabolite	Metabolic Disease
Phosphocreatine dipotassium, primarily found in the skeletal muscles of vertebrates and one of organic compounds known as alpha amino acids and derivatives, is a substrate for the determination of creatine kinase and used to regenerate ATP during skeletal muscle contraction.

HY-101762

TyK2-IN-2	JAK Phosphodiesterase (PDE)	Inflammation/Immunology
TyK2-IN-2 (Compoud 18) is a potent and selective TYK2 inhibitor with IC₅₀s of 7 nM, 0.1 μM and 0.05 μM for TYK2 JH2, IL-23 and IFNα, respectively. TyK2-IN-2 also inhibits phosphodiesterase 4 (PDE4) with an IC₅₀ of 62 nM. TyK2-IN-2 can be used for the research of inflammatory and autoimmune diseases.

HY-P1674A

Murepavadin TFA POL7080 TFA	Bacterial Antibiotic	Infection
Murepavadin (TFA), a 14-amino-acid cyclic peptide, is a highly potent, specific antibiotic for the treatment of bacterial infections caused by Pseudomonas aeruginosa. Murepavadin (TFA) targets the lipopolysaccharide transport portin D .

HY-B0762

Acetyl-L-carnitine hydrochloride O-Acetyl-L-carnitine (hydrochloride)	Endogenous Metabolite	Neurological Disease
Acetyl-L-carnitine hydrochloride is a blood-brain permeable acetyl ester of the amino acid L-carnitine found in the body. Acetyl-L-carnitine hydrochloride is often used as a dietary supplement, and exibits anti-stress-related psychiatric disorders.

HY-D0885A

Phosphocreatine disodium tetrahydrate Creatine phosphate (disodium tetrahydrate); Creatinephosphoric acid (disodium tetrahydrate)	Endogenous Metabolite	Metabolic Disease
Phosphocreatine disodium tetrahydrate, primarily found in the skeletal muscles of vertebrates and one of organic compounds known as alpha amino acids and derivatives, is a substrate for the determination of creatine kinase and used to regenerate ATP during skeletal muscle contraction.

HY-100714A

D-AP5
D-APV; D-2-Amino-5-phosphonovaleric acid
iGluR Neurological Disease

D-AP5 is a NMDA receptor antagonist.

HY-131262

Hydroxychloroquine Impurity E 4-[(7-Chloro-4-quinolinyl)Amino]-1-pentanol	Others	Others
Hydroxychloroquine Impurity E is the impurity of Hydroxychloroquine. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro.

HY-P1847

IKKγ NBD Inhibitory Peptide	NF-κB	Cancer
IKKγ NBD Inhibitory Peptide is a NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region, which is shown to block TNF-alpha-induced NF-kB activation.

HY-129770A

D-Methionine sulfoxide hydrochloride	Others	Metabolic Disease
D-methionine sulfoxide hydrochloride is the D-isomer of Methionine sulfoxide hydrochloride. Methionine sulfoxide is an oxidation product of methionine. Methionine is the limiting amino acid in milk or leguminous proteins, which is easily oxidized during the course of storage or processing.

HY-129770

D-Methionine sulfoxide	Endogenous Metabolite	Metabolic Disease
D-methionine sulfoxide is the D-isomer of Methionine sulfoxide. Methionine sulfoxide is an oxidation product of methionine. Methionine is the limiting amino acid in milk or leguminous proteins , which is easily oxidized during the course of storage or processing.

HY-13943

CNX-774	Btk	Cancer
CNX-774 is a potent, selective, and orally available small molecule inhibitor of Btk (IC50< 1 nM) that forms a ligand-directed covalent bond with Cys-481, a non-conserved amino acid within the active site of the enzyme.

HY-N3945

Glaucine O,O-Dimethylisoboldine; S-(+)-Glaucine; NSC 34396	Phosphodiesterase (PDE) Calcium Channel Adrenergic Receptor Dopamine Receptor Influenza Virus	Infection Inflammation/Immunology
Glaucine (O,O-Dimethylisoboldine) is an alkaloid isolated from Glaucium flavum Crantz with antitussive, bronchodilation and anti-inflammatory properties. Glaucine is a selective and orally active phosphodiesterase 4 (PDE4) inhibitor with K_is of 3.4 µM in human bronchus and polymorphonuclear leukocytes. Glaucine is also a non-selective α-adrenoceptor antagonist, a Ca²⁺ entry blocker, and a weak dopamine D1 and D2 receptor antagonist. Glaucine has antioxidative and antiviral activities.

HY-111434

UAA crosslinker 1	Others	Cancer
UAA crosslinker 1 hydrochloride is an amber codon used for non-canonical amino acids (ncAAs) incorporation. The ncAAs can be incorporated into proteins in vivo by making use of the promiscuous activity of certain wildtype and engineered aminoacyl-tRNA synthetases.

HY-P1418

DPC-AJ1951	Thyroid Hormone Receptor	Endocrinology
DPC-AJ1951, a 14 amino acid peptide that acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR) , and characterized its activity in ex vivo and in vivo assays of bone resorption.

HY-111434A

UAA crosslinker 1 hydrochloride	Others	Cancer
UAA crosslinker 1 hydrochloride is an amber codon used for non-canonical amino acids (ncAAs) incorporation. The ncAAs can be incorporated into proteins in vivo by making use of the promiscuous activity of certain wildtype and engineered aminoacyl-tRNA synthetases.

HY-P1847A

IKKγ NBD Inhibitory Peptide TFA	NF-κB	Inflammation/Immunology
IKKγ NBD Inhibitory Peptide TFA is a NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region, which is shown to block TNF-alpha-induced NF-kB activation.

HY-P0256

Apamin Apamine	Potassium Channel	Inflammation/Immunology Neurological Disease
Apamin (Apamine) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca²⁺-activated K⁺ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity.

HY-P1418A

DPC-AJ1951 TFA	Thyroid Hormone Receptor	Endocrinology
DPC-AJ1951 TFA, a 14 amino acid peptide that acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR) , and characterized its activity in ex vivo and in vivo assays of bone resorption.

HY-Y0337A

L-Cysteine hydrochloride	Endogenous Metabolite	Metabolic Disease
L-Cysteine hydrochloride is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride suppresses ghrelin and reduces appetite in rodents and humans.

HY-P1770

Adrenomedullin (16-31), human	CGRP Receptor	Cardiovascular Disease
Adrenomedullin (16-31), human is amino acid residues 16-31 fragment of human adrenomedullin (hADM). Adrenomedullin has appreciable affinity for the CGRP1 receptor. Adrenomedullin (16-31), human possesses pressor activity in the systemic vascular bed of the rat, but not the cat.

HY-P1340A

[Ala11,D-Leu15]-Orexin B(human) TFA	Orexin Receptor (OX Receptor)	Neurological Disease
[Ala11,D-Leu15]-Orexin B(human) TFA is a potent and selective orexin-2 receptor (OX2) agonist. [Ala11,D-Leu15]-Orexin B(human) TFA shows a 400-fold selectivity for the OX2 (EC₅₀=0.13 nM) over OX1 (52 nM).

HY-103355

YM022	CCR	Metabolic Disease
YM022 is a highly potent, selective and orally active gastrin/cholecystokinin (CCK)-B receptor (CCK-BR) antagonist. YM022 shows the K_i values of 68 pM and 63 nM for CCK-B and CCK-A receptor, respectively. YM022 can inhibit gastrin-induced gastric acid secretion and histidine decarboxylase activation in vivo.

HY-113437

1,2-Dipalmitoyl-sn-glycerol 3-phosphate	Endogenous Metabolite	Metabolic Disease
1,2-Dipalmitoyl-sn-glycerol 3-phosphate (compound 3-F7) is a phosphatidic acid and a human endogenous metabolite.

HY-W008097

3,3-Dimethylglutaric acid	Endogenous Metabolite	Metabolic Disease
3,3-Dimethylglutaric acid, a member of methyl-branched fatty acids, is a endogenous metabolite occasionally found in human urine.

HY-130803

5-Methyl-5,6-dihydrouridine	Others	Cancer
5-Methyl-5,6-dihydrouridine is a minor constituent in the chromosomal RNA of the rat ascites tumor. 5-Methyl-5,6-dihydrouridine can be used for nucleic acid modification.

HY-113437A

1,2-Dipalmitoyl-sn-glycerol 3-phosphate sodium	Endogenous Metabolite	Metabolic Disease
1,2-Dipalmitoyl-sn-glycerol 3-phosphate sodium (compound 3-F7) is a phosphatidic acid and a human endogenous metabolite

HY-116100A

HA155
Phosphodiesterase (PDE) Inflammation/Immunology

HA-155 is a potent and selective autotaxin (ATX) inhibitor with an IC₅₀ of 5.7 nM.

HY-135103

*Tauro-β-muricholic acid* sodium** T-βMCA sodium	FXR	Cancer
Tauro-β-muricholic Acid sodium (T-βMCA sodium), a endogenous metabolite, is a competitive and reversible farnesoid X receptor (FXR) antagonist, with an IC₅₀ of 40 μM.

HY-W009082

Methyl behenate
Methyl docosanoate
Others Others

Methyl behenate (Methyl docosanoate) is a naturally fatty acid methyl ester isolated from the plant of Aspidopterys obcordata Lemsl.

HY-P1340

[Ala11,D-Leu15]-Orexin B(human)	Orexin Receptor (OX Receptor)	Neurological Disease
[Ala11,D-Leu15]-Orexin B(human) is a potent and selective orexin-2 receptor (OX2) agonist. [Ala11,D-Leu15]-Orexin B(human) shows a 400-fold selectivity for the OX2 (EC₅₀=0.13 nM) over OX1 (52 nM).

HY-112754A

DOTAP chloride 1,2-Dioleoyl-3-trimethylammonium-propane chloride	Others	Others
DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) with out the use of helper lipid.

HY-133022

trans-2-Undecenoic acid (E)-2-Undecenoic acid; (E)-Undec-2-enoic acid	Others	Metabolic Disease
trans-2-Undecenoic acid ((E)-2-Undecenoic acid) is an α,β-unsaturated carboxylic acid and is characterized by acid dimers. The corresponding dimers are connected via intermolecular hydrogen bonds of the carboxylic groups C=O···H-O.

HY-W005178

Octadecanedioic acid	Endogenous Metabolite	Others
Octadecanedioic acid, an endogenous metabolite, is a long-chain dicarboxylic acid that has been found in serum free fatty acid profile in Reye syndrome.

HY-N7354

Quininic acid
Others Cardiovascular Disease

Quininic acid, purified from Eucalyptus globulus, cinchona bark, and other plant products, is the most abundant organic acid.

HY-A0143

Dihomo-γ-linolenic acid all-cis-8,11,14-Eicosatrienoic acid	Endogenous Metabolite	Cancer Inflammation/Immunology Cardiovascular Disease
Dihomo-γ-linolenic acid (all-cis-8,11,14-Eicosatrienoic acid) is a 20-carbon ω-6 fatty acid, with anti-inflammatory and anti-proliferative activities. Dihomo-γ-linolenic acid attenuates atherosclerosis in the apolipoprotein E deficient mouse model system.

HY-P7060

NT 13 TPPT	iGluR	Neurological Disease
NT 13 (TPPT) is a tetrapeptide having the amino acid sequence L-threonyl-L-prolyl-L-prolyl-L-threonine amide. NT 13 is a partial N-methyl-D-aspartate receptor (NMDAR) agonist used in the study of depression, anxiety, and other related diseases.

HY-112136

TAO Kinase inhibitor 1	Others	Cancer
TAO Kinase inhibitor 1 (compound 43) is a selective, ATP-competitive *thousand-and-one amino* acid kinases (TAOK) inhibitor with IC₅₀**s of 11 to 15 nM for TAOK1 and 2, respectively. TAO Kinase inhibitor 1 delays mitosis and induces mitotic cell death.

HY-N6858

4-Hydroxyisoleucine 4-Hydroxy-L-isoleucine	Others	Metabolic Disease
4-Hydroxyisoleucine (4-Hydroxy-L-isoleucine) is an amino acid which can be extracted and purified from fenugreek seeds. 4-Hydroxyisoleucine (4-Hydroxy-L-isoleucine) displays an insulinotropic activity of great interest.

HY-A0282

L-Ornithine L-aspartate	Others	Metabolic Disease
L-Ornithine L-aspartate is a stable salt of two natural nonessential L-amino acids: ornithine and aspartic acid. L-Ornithine L-aspartate lowers blood ammonia concentration and to eliminate symptoms of hepatic encephalopathy associated with liver cirrhosis.

HY-B0236

6-Aminocaproic acid EACA; Epsilon-Amino-n-caproic Acid; 6-Aminohexanoic acid	Others	Metabolic Disease
6-Aminocaproic acid is an antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.

HY-P0256A

Apamin TFA Apamine TFA	Potassium Channel	Inflammation/Immunology Neurological Disease
Apamin TFA (Apamine TFA) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca²⁺-activated K⁺ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity.

HY-107522

DL-TBOA	EAAT2	Neurological Disease
DL-TBOA is a potent non-transportable inhibitor of excitatory amino acid transporters with IC₅₀s of 70 μM, 6 μM and 6 μM for *excitatory amino* acid transporter-1 (EAAT1), EAAT2 and EAAT3, respectively. DL-TBOA inhibits the uptake of [¹⁴C]glutamate in COS-1 cells expressing the human EAAT1 and EAAT2 with K_i valuesof 42 μM and 5.7 μM, respectively. DL-TBOA blocks EAAT4 and EAAT5 in a competitive manner with K_i** values of 4.4 μM and 3.2 μM, respectively.

HY-122872

MKK7-COV-9	p38 MAPK	Cancer
MKK7-COV-9 is a potent and selective covalent inhibitor of MKK7 and targets a specific protein–protein interaction of MKK7. MKK7-COV-9 blocks primary B cell activation in response to LPS with an EC₅₀ of 4.98 μM.

HY-75308

Azetidine-2-carboxylic acid	Others	Cancer
Azetidine-2-carboxylic acid is a non proteinogenic amino acid homologue of proline. Found in common beets. Azetidine-2-carboxylic acid can be misincorporated into proteins in place of proline in many species, including humans. Toxic and teratogenic agent.

HY-P1298

Sauvagine	CRFR	Endocrinology Neurological Disease Cardiovascular Disease
Sauvagine, a 40-amino-acid neuropeptide from the skin of the frog, is a mammalian CRF agonist. Sauvagine is effective at releasing ACTH from rat pituitary cells. Sauvagine possesses a number of pharmacological actions on diuresis, the cardiovascular system and endocrine glands.

HY-19528

SAH SAH (S-Adenosylhomocysteine)	Endogenous Metabolite	Metabolic Disease
SAH is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC₅₀ of 0.9 µM.

HY-P1293

Conantokin G	iGluR	Neurological Disease
Conantokin G, a 17-amino-acid peptide, is a potent, selective and competitive antagonist of N-methyl-D-aspartate (NMDA) receptors. Conantokin G inhibits NMDA-evoked currents in murine cortical neurons with an IC₅₀ of 480 nM. Conantokin G has neuroprotective properties.

HY-113130

Eicosadienoic acid
Endogenous Metabolite Metabolic Disease

Eicosadienoic acid is a rare, naturally occurring n-6 polyunsaturated fatty acid found mainly in animal tissues.
HY-124422

Pentacosanoic acid
Endogenous Metabolite Metabolic Disease

Pentacosanoic acid is a 25-carbon long-chain saturated fatty acid. Pentacosanoic is a conjugate acid of a pentacosanoate.

HY-W018512

7-Ketolithocholic acid 3α-Hydroxy-7-oxo-5β-cholanic acid	Endogenous Metabolite	Metabolic Disease
7-Ketolithocholic acid (3α-Hydroxy-7-oxo-5β-cholanic acid), a bile acid, can be absorbed and suppresses endogenous bile acid production and biliary cholesterol secretion.

HY-117145

Thiophene-2 TP2	Bacterial	Infection
Thiophene-2 (TP2) is a specific polyketide synthase 13 (Pks13) inhibitor. Thiophene-2 inhibits mycolic acid biosynthesis and rapidly leads to mycobacterial cell death. Thiophene-2 is active against *Mycobacterium tuberculosis* with a MIC value of 1 μM, and has potent anti-tuberculosis activity.

HY-N7031

(±)-Vasicine (±)-Peganine	Proton Pump	Inflammation/Immunology
(±)-Vasicine is the racemate of Vasicine. Vasicine (Peganine), isolated from Peganum harmala seeds, significantly inhibits H⁺-K⁺-ATPase activity in vitro with an IC₅₀ of 73.47 μg/mL. Anti-ulcer activity. Vasicine shows significant anti-secretory, antioxidant and cytoprotective effect.

HY-113972A

(E/Z)-Methyl mycophenolate	Others	Inflammation/Immunology
(E/Z)-Methyl mycophenolate is a racemic compound of (Z)-Methyl mycophenolate and (E)-Methyl mycophenolate isomers. Methyl mycophenolate is a methyl ester of mycophenolic acid. Methyl mycophenolate can be used to synthesize mycophenolic acid β-D-glucuronide and phenolic glycosides.

HY-W010832

Uridine-5'-diphosphate disodium salt	P2Y Receptor DNA/RNA Synthesis Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
Uridine-5'-diphosphate disodium salt is a potent, selective P2Y₆ receptor native agonist (EC₅₀=300 nM; pEC₅₀=6.52) and a potent P2Y₁₄ antagonist (pEC₅₀=7.28). Uridine-5'-diphosphate disodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis.

HY-W015495

L-Dihydroorotic acid
Endogenous Metabolite Others

L-Dihydroorotic acid can reversibly hydrolyze to yield the acyclic L-ureidosuccinic acid by dihydrowhey enzyme.

HY-W011688

Methyl palmitoleate (Z)-Methyl hexadec-9-enoate; Methyl cis-9-Hexadecenoate	Others	Others
Methyl palmitoleate ((Z)-Methyl hexadec-9-enoate), a fatty acid methyl ester, is an analogue of Palmitoleate with cytoprotective and growth-promoting properties.

HY-W010820

Uridine 5'-diphosphate sodium salt	P2Y Receptor DNA/RNA Synthesis Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
Uridine 5'-diphosphate sodium salt is a potent, selective P2Y₆ receptor native agonist (EC₅₀=300 nM; pEC₅₀=6.52) and a potent P2Y₁₄ antagonist (pEC₅₀=7.28). Uridine 5'-diphosphate sodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis.

HY-Y0444

D-Tyrosine	Tyrosinase	Metabolic Disease
D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth.

HY-135795

1-Cyclohexyl-3-dodecyl urea CDU; N-Cyclohexyl-N-dodecyl urea; NCND	Epoxide Hydrolase	Metabolic Disease Cardiovascular Disease
1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) is a highly selective soluble epoxide hydrolase (sEH) inhibitor. 1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) increases epoxyeicosatrienoic acids (EETs) levels and lowers blood pressure in angiotensin II (Ang II) hypertension.

HY-N4120

Valechlorine	Autophagy	Metabolic Disease
Valechlorine, a autophagy enhancer, breaks down lipid droplets. Valechlorine reduces oleic acid (OA)-induced lipid accumulation in an Atg5-dependent manner.

HY-W001959

D-Allothreonine	Endogenous Metabolite	Metabolic Disease
D-Allothreonine is the D type stereoisomer of Allothreonine. D-Allothreonine is a peptido-lipid derived from bacteria. D-Allothreonine, amide-linked to the D-galacturonic acid, is also a constituent in the polysaccharide.

HY-N6998

Paederosidic acid	Apoptosis	Cancer
Paederosidic acid is isolated from P. scandens with anticancer and anti‐inflammation activities. Paederosidic acid inhibits lung caner cells via inducing mitochondria-mediated apoptosis.

HY-N7132

Menthyl acetate L-Menthyl acetate; (-)-Menthyl acetate	Others	Others
Menthyl acetate (L-Menthyl acetate) is a derivative of L-menthol. Menthyl acetate is effective to enhance 5-aminolevulinic acid (ALA) skin permeation.

HY-16007

(-)-Hydroxycitric acid Garcinia acid	ATP Citrate Lyase	Metabolic Disease
(-)-Hydroxycitric acid (Garcinia acid) is the principal acid of fruit rinds of Garcinia cambogia. (-)-Hydroxycitric acid is a potent and competitive inhibitor of ATP citrate lyase. (-)-Hydroxycitric acid suppresses the fatty acid synthesis, lipogenesis, food intake, and induced weight loss.

HY-P1072

PHM-27 (human)	CGRP Receptor	Metabolic Disease Cardiovascular Disease
PHM-27 (human) is a human prepro-vasoactive intestinal polypeptide (27 amino acid). PHM-27 (human) is a potent the human calcitonin receptor agonist with an EC₅₀ of 11 nM. PHM-27 (human) efficiently enhances glucose-induced insulin secretion from beta cells by an autocrine mechanism.

HY-P1298A

Sauvagine TFA	CRFR	Endocrinology Neurological Disease Cardiovascular Disease
Sauvagine TFA, a 40-amino-acid neuropeptide from the skin of the frog, is a mammalian CRF agonist. Sauvagine TFA is effective at releasing ACTH from rat pituitary cells. Sauvagine TFA possesses a number of pharmacological actions on diuresis, the cardiovascular system and endocrine glands.

HY-21577

Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine	ADC Linker PROTAC Linker	Cancer
Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-B1125

Glucosamine D-Glucosamine; Chitosamine	Endogenous Metabolite Reactive Oxygen Species HIF/HIF Prolyl-Hydroxylase Autophagy	Inflammation/Immunology
Glucosamine (D-Glucosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes.

HY-N0733

Glucosamine hydrochloride D-(+)-Glucosamine hydrochloride; Chitosamine hydrochloride	Endogenous Metabolite Reactive Oxygen Species HIF/HIF Prolyl-Hydroxylase Autophagy	Inflammation/Immunology Cancer
Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine hydrochloride also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes.

HY-112052

Aminomalonic acid	Endogenous Metabolite	Cancer
Aminomalonic acid is an amino endogenous metabolite, acts as a strong inhibitor of L-asparagine synthetase from Leukemia 5178Y/AR (K_i= 0.0023 M) and mouse pancreas (K_i= 0.0015 M) in vitro. Aminomalonic acid is a potential biomarker to discriminate between different stages of melanoma metastasis.

HY-P1293A

Conantokin G TFA	iGluR	Neurological Disease
Conantokin G TFA, a 17-amino-acid peptide, is a potent, selective and competitive antagonist of N-methyl-D-aspartate (NMDA) receptors. Conantokin G TFA inhibits NMDA-evoked currents in murine cortical neurons with an IC₅₀ of 480 nM. Conantokin G TFA has neuroprotective properties.

HY-N0487

Glucosamine sulfate D-Glucosamine sulfate	Endogenous Metabolite Reactive Oxygen Species HIF/HIF Prolyl-Hydroxylase Autophagy	Inflammation/Immunology Cancer
Glucosamine sulfate (D-Glucosamine sulfate) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine sulfate also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes.

HY-106224

Orexin A (human, rat, mouse)	Orexin Receptor (OX Receptor)	Neurological Disease
Orexin A human, rat, mouse, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A human, rat, mouse is a specific, high-affinity agonist for G-protein-coupled receptor OX1R. Orexin A human, rat, mouse has a role in the regulation of feeding behavior. Orexin A human, rat, mouse is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.

HY-P1306

Obestatin(rat)	GHSR	Inflammation/Immunology Cardiovascular Disease
Obestatin(rat), encoded by the Ghrelin gene, is a cpeptide, comprised of 23 amino acids. Obestatin(rat) suppresses food intake, inhibits jejunal contraction, and decreases body-weight gain. Obestatin is an endogenous ligand of G-protein coupled receptor 39 (GPR39). Obestatin(rat) has anti-inflammatory, anti-myocardial infarction and antioxidant activities.

HY-128923

SKF-34288 hydrochloride 3-Mercaptopicolinic acid hydrochloride	Others	Metabolic Disease
SKF-34288 hydrochloride (3-Mercaptopicolinic acid) is a phosphoenolpyruvate carboxykinase (PEPCK) inhibitor. SKF-34288 hydrochloride is a potent hypoglycemic agent via inhibition of glucose synthesis through the specific inhibition of PEPCK in the gluconeogenesis pathway. SKF-34288 hydrochloride inhibits Asn metabolism and results in an increase in amino acids and amides.

HY-D1117

NADA-green NADA hydrochloride	Others
NADA-green, a fluorescent D-amino acid, suitable for labeling peptidoglycans in live bacteria. NADA-green is incorporated into bacterial cell walls during synthesis. NADA-green results in strong peripheral and septal labeling of taxonomically diverse bacterial cell populations without affecting growth rate. Excitation/emission λ ~450/555 nm.

HY-124527

HET0016	Cytochrome P450	Cardiovascular Disease
HET0016 is a potent and selective 20-hydroxyeicosatetraenoic acid (20-HETE) synthase inhibitor, with IC₅₀ values of 17.7 nM, 12.1 nM and 20.6 nM for recombinant CYP4A1-, CYP4A2- and CYP4A3-catalyzed 20-HETE synthesis, respectively. HET0016 also is a selective CYP450 inhibitor, which has been shown to inhibit angiogenesis and tumor growth.

HY-N2581

*Phytic acid* sodium salt** myo-Inositol, hexakis(dihydrogen phosphate) sodium salt; Inositol hexaphosphate sodium salt	Others	Others
Phytic acid sodium salt (myo-Inositol; hexakis dihydrogen phosphate; Inositol hexaphosphat) is often present in legume seeds with antinutritional effects. Phytic acid sodium salt is a [PO4]³- storage depot and precursor for other inositol phosphates and pyrophosphates. phytic acid is hydrolyzed by phytases in a stepwise manner in the plant.

HY-A0208

Rosoxacin Acrosoxacin	Bacterial Antibiotic	Infection
Rosoxacin (Acrosoxacin) is a potent and orally active quinolone antibiotic. Rosoxacin (Acrosoxacin) has antibacterial activities against a broad spectrum of Gram negative bacteria including Neisseria gonorrhoeae (MIC₉₀=0.03mg/ml). Rosoxacin has the potential for urinary tract infections treatment.

HY-B1132

Clidinium bromide Ro 2-3773	mAChR	Neurological Disease
Clidinium bromide is a quaternary amine antimuscarinic agent. Clidinium bromide may help symptoms of cramping and abdominal/stomach pain by decreasing stomach acid, and slowing the intestines in vivo.

HY-N6877

Purpurogallin carboxylic acid	Others	Cancer
Purpurogallin carboxylic acid, isolated from Macleaya microcarpa (Maxim.) Fedde, is an oxidation product of gallic acid in fermented tea. Purpurogallin carboxylic acid has anti-cancer activity.

HY-133068

5-Hydroxyferulic acid	COMT	Others
5-Hydroxyferulic acid is a hydroxycinnamic acid and is a metabolite of the phenylpropanoid pathway. 5-Hydroxyferulic acid is a precursor in the biosynthesis of sinapic acid and is also a COMT non-esterifed substrate.

HY-W010629

2-Chloroacetamide	Bacterial	Infection
2-Chloroacetamide is a preservative and is a herbicide for both uplands and paddy fields. 2-Chloroacetamide is a biocide in agriculture, glues, paints and coatings. 2-Chloroacetamide inhibits very-long-chain fatty acid elongase.

HY-109079A

Abeprazan hydrochloride DWP14012 hydrochloride	Proton Pump	Metabolic Disease
Abeprazan hydrochloride (DWP14012 hydrochloride) is a potassium-competitive acid blocker. Abeprazan hydrochloride inhibits H⁺, K⁺- ATPase by reversible potassium-competitive ionic binding with no acid activation required. Abeprazan hydrochloride is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases.

HY-B0946

Sulfamonomethoxine	Bacterial Antibiotic	Infection
Sulfamonomethoxine is a long acting sulfonamide antibacterial agent, used in blood kinetic studies,and blocks the synthesis of folic acid by inhibiting synthetase of dihydropteroate.

HY-W010062

4-Chlorophenylacetic acid	Others	Cancer Metabolic Disease
4-Chlorophenylacetic acid is a compound belongs to a family of small aromatic fatty acids with anticancer properties. 4-Chlorophenylacetic acid can provide carbon and energy for Pseudomonas sp.

HY-76199

trans-4-Hydroxycyclohexanecarboxylic acid	Others	Metabolic Disease
trans-4-Hydroxycyclohexanecarboxylic acid is a substrate for cyclohexanecarboxylic acid production. trans-4-Hydroxycyclohexanecarboxylic acid is the by-product of intestinal bacterial metabolism via urinary excretion.

HY-P1202A

CYN 154806 TFA	Somatostatin Receptor	Endocrinology
CYN 154806 TFA, a cyclic octapeptide, is a potent and selective somatostatin sst2 receptor antagonist, with pIC₅₀ values of 8.58, 5.41, 6.07, 5.76 and 6.48 for human recombinant sst2, sst1, sst3, sst4 and sst5 receptors respectively.

HY-16100

BI99179	Fatty Acid Synthase (FASN)	Cancer Metabolic Disease
BI99179 is a potent and selective type I fatty acid synthase (FASN) inhibitor with an IC₅₀ of 79 nM. BI 99179 exhibits significant exposure (both peripheral and central) upon oral administration in rats.

HY-W015343

3-Methoxyphenylacetic acid m-Methoxyphenylacetic acid	Others	Infection
3-Methoxyphenylacetic acid (m-Methoxyphenylacetic acid), a m-hydroxyphenylacetic acid (m-OHPAA) derivative, is a phytotoxin in Rhizoctonia solani. 3-Methoxyphenylacetic acid is used to develop a toxin-mediated bioassay for resistance to rhizoctonia root rot.

HY-B0946S

Sulfamonomethoxine D4	Bacterial	Infection
Sulfamonomethoxine D4 is a deuterium labeled Sulfamonomethoxine. Sulfamonomethoxine is a long acting sulfonamide antibacterial agent, used in blood kinetic studies,and blocks the synthesis of folic acid by inhibiting synthetase of dihydropteroate.

HY-P1202

CYN 154806	Somatostatin Receptor	Endocrinology
CYN 154806, a cyclic octapeptide, is a potent and selective somatostatin sst2 receptor antagonist, with pIC₅₀ values of 8.58, 5.41, 6.07, 5.76 and 6.48 for human recombinant sst2, sst1, sst3, sst4 and sst5 receptors respectively.

HY-N1272

Secaubryenol	Endogenous Metabolite	Others
Secaubryenol is a class of 3,4-secocycloartane triterpenes isolated from Coussarea macrophylla. Secaubryenol does not display any cytotoxic effect at a dose of 10 µg/mL.

HY-N2078

Yamogenin Neodiosgenin	LXR	Metabolic Disease
Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin (Neodiosgenin) antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin (Neodiosgenin) inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes.

HY-109079

Abeprazan DWP14012	Proton Pump	Metabolic Disease
Abeprazan (DWP14012) is a potassium-competitive acid blocker. Abeprazan inhibits H⁺, K⁺- ATPase by reversible potassium-competitive ionic binding with no acid activation required. Abeprazan is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases.

HY-N2511

Trimyristin	AChE Phosphatase Endogenous Metabolite	Metabolic Disease
Trimyristin, an active molluscicidal component of Myristica fragrans Houtt, significantly inhibits acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue of Lymnaea acuminata. IC₅₀s of Trimyristin against AChE, ACP, and ALP are 0.11, 0.16 and 0.18 mM, respectively.

HY-P1525

Melanin Concentrating Hormone, salmon MCH (salmon)	MCHR1 (GPR24)	Metabolic Disease Neurological Disease Cardiovascular Disease Endocrinology
Melanin Concentrating Hormone, salmon is a 19-amino-acid neuropeptide initially identified in the pituitary gland of teleost fish, which regulates food intake, energy balance, sleep state, and the cardiovascular system. Melanin-concentrating hormone is a ligand for an orphan G protein-coupled receptor (SLC-1/GPR24) and MCHR2.

HY-100808

(R)-Serine	iGluR Endogenous Metabolite	Others
(R)-Serine, an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. (R)-Serine has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration.

HY-N6704

Enniatin A1	ERK Apoptosis	Cancer
Enniatin A1 isolated from Fusarium mycotoxins is a cyclic hexadepsipeptide consisting of alternating D-α-hydroxyisovaleric acids and N-methyl-L-amino acids. Enniatin A1 possesses anticarcinogenic properties by induction of apoptosis and disruption of ERK signalling pathway. Enniatin A1 inhibits ACAT with an IC₅₀ of 49 μM in rat liver microsomes.

HY-133513

(±)-H3RESCA-TFP (±)-H3L28	Others	Cancer
(±)-H3RESCA-TFP ((±)-H3L28) is a tetrafluorophenyl ester derivative of restrained complexing agent (RESCA). (±)-H3RESCA-TFP can be used to conjugate the chelator with a biomolecule via amine coupling (e.g., N terminus and/or the ε-amino groups of lysine).

HY-107784

Ectoine	Bacterial	Inflammation/Immunology
Ectoine is a natural cell protectant, an amino acid derivate produced by bacteria living under extremely harsh environmental conditions. Ectoine serves as an osmoregulatory compatible solute, increasing the hydration of the skin surface and stabilizing lipid layers, which is useful in skincare. Ectoine demonstrates a good safety profile for the treatment of allergic rhinitis.

HY-125845A

(S,S,S)-AHPC hydrochloride (S,S,S)-VH032-NH2 hydrochloride	Ligand for E3 Ligase	Cancer
(S,S,S)-AHPC hydrochloride is a von Hippel-Lindau (VHL) amino building block. (S,S,S)-AHPC is a ligand used as a negative control for (S,R,S)-AHPC. (S,R,S)-AHPC is the VH032-based VHL ligand used in the recruitment of the VHL protein.

HY-P1306A

Obestatin(rat) TFA	GHSR	Inflammation/Immunology Cardiovascular Disease
Obestatin(rat) TFA, encoded by the Ghrelin gene, is a cpeptide, comprised of 23 amino acids. Obestatin(rat) TFA suppresses food intake, inhibits jejunal contraction, and decreases body-weight gain. Obestatin is an endogenous ligand of G-protein coupled receptor 39 (GPR39). Obestatin(rat) TFA has anti-inflammatory, anti-myocardial infarction and antioxidant activities.

HY-106783

Polymyxin B nonapeptide	Bacterial Antibiotic	Infection
Polymyxin B nonapeptide is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue. Polymyxin B nonapeptide is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes.

HY-P1525A

Melanin Concentrating Hormone, salmon TFA MCH (salmon) (TFA)	MCHR1 (GPR24)	Metabolic Disease Neurological Disease Cardiovascular Disease Endocrinology
Melanin Concentrating Hormone, salmon TFA (MCH (salmon) TFA) is a 19-amino-acid neuropeptide initially identified in the pituitary gland of teleost fish, which regulates food intake, energy balance, sleep state, and the cardiovascular system. Melanin-concentrating hormone is a ligand for an orphan G protein-coupled receptor (SLC-1/GPR24) and MCHR2.

HY-106224A

Orexin A (human, rat, mouse) (TFA)	Orexin Receptor (OX Receptor)	Neurological Disease
Orexin A human, rat, mouse TFA, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A human, rat, mouse TFA is a specific, high-affinity agonist for G-protein-coupled receptor OX1R. Orexin A human, rat, mouse TFA has a role in the regulation of feeding behavior. Orexin A human, rat, mouse TFA is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.

HY-112683

V-9302	Others	Cancer
V-9302 is a competitive antagonist of transmembrane glutamine flux. V-9302 selectively and potently targets the amino acid transporter ASCT2 (SLC1A5). V-9302 inhibits ASCT2-mediated glutamine uptake (IC₅₀=9.6 µM) in HEK-293 cells.

HY-112683A

V-9302 hydrochloride	Others	Cancer
V-9302 hydrochloride is a competitive antagonist of transmembrane glutamine flux. V-9302 hydrochloride selectively and potently targets the amino acid transporter ASCT2 (SLC1A5). V-9302 hydrochloride inhibits ASCT2-mediated glutamine uptake (IC₅₀=9.6 µM) in HEK-293 cells.

HY-P1051

β-amyloid (12-28) Amyloid β-Protein (12-28)	Amyloid-β	Neurological Disease
β-amyloid (12-28) is a peptide fragment of β-amyloid protein (β1-42). β1–42 a 42 amino acid protein , is the major component of senile plaque cores. β-amyloid (12-28) shows aggregation properties. β-amyloid (12-28) has the potential for Alzheimer’s disease research.

HY-106783A

Polymyxin B nonapeptide TFA	Bacterial	Infection
Polymyxin B nonapeptide TFA is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue. Polymyxin B nonapeptide TFA is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes.

HY-15121

L-Theanine L-Glutamic Acid γ-ethyl amide; Nγ-Ethyl-L-glutamine	Apoptosis	Neurological Disease
L-Theanine (L-Glutamic Acid γ-ethyl amide）is a non-protein amino acid contained in green tea leaves, which blocks the binding of L-glutamic acid to glutamate receptors in the brain, and with neuroprotective and anti-oxidative activities. L-Theanine causes anti-stress effects via the inhibition of cortical neuron excitation by oral intake.

HY-P1051A

β-amyloid (12-28) (TFA) Amyloid β-Protein (12-28) (TFA)	Amyloid-β	Neurological Disease
β-amyloid (12-28) TFA is a peptide fragment of β-amyloid protein (β1-42). β1–42 a 42 amino acid protein , is the major component of senile plaque cores. β-amyloid (12-28) shows aggregation properties. β-amyloid (12-28) has the potential for Alzheimer’s disease research.

HY-135747

Gut restricted-7 GR-7	Bacterial	Infection
Gut restricted-7 (GR-7) is a potent, covalent and orally active pan-bile salt hydrolase (BSH) inhibitor. Gut restricted-7 decreases gut bacterial BSHs and decreases deconjugated bile acid levels in feces of mice.

HY-N7387

3-Oxocholic acid	Endogenous Metabolite	Metabolic Disease
3-Oxocholic acid is an oxo-bile acid metabolite and also a major degradation product from cholic by C. perfringens in the intestine. 3-Oxocholic acid is steroid acid found predominantly in bile of mammals.

HY-107613

R 59-022 DKGI-I; Diacylglycerol kinase inhibitor I	PKC 5-HT Receptor	Inflammation/Immunology
R 59-022 (DKGI-I) is a diacylglycerol kinase inhibitor (IC₅₀=2.8 μM). R 59-022 is a 5-HTR antagonist, and activates protein kinase C (PKC). R 59-022 potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils.

HY-135283

ABT-546 A-216546	Endothelin Receptor	Endocrinology Cardiovascular Disease
ABT-546 (A-216546) is a potent, highly selective and active endothelin ET_A receptor antagonist with a K_i of 0.46 nM for [¹²⁵I]endothelin-1 binding to cloned human endothelin ET_A. ABT-546 is ＞25,000-fold more selective for the ET_A receptor than for the ET_B receptor. ABT-546 blocks endothelin-1-induced arachidonic acid release and phosphatidylinositol hydrolysis with IC₅₀ of 0.59 nM and 3 nM, respectively.

HY-P1125

4-CMTB
Others Others

4-CMTB is a selective free fatty acid receptor 2 (FFA2/GPR43) agonist and a positive allosteric modulator (pEC₅₀=6.38).

HY-119435

Triallate	Others	Others
Triallate is a selective preemergence herbicide for the control of wild oats in barley, spring wheat, Durum wheat, winter wheat, and sugar beets. Triallate inhibits fatty acid elongation and surface lipid (wax) biosynthesis.

HY-N2920

β-Amyrenonol 11-Oxo-β-amyrin	Cytochrome P450	Cancer Inflammation/Immunology
β-Amyrenonol (11-Oxo-β-amyrin), an oleanolic-type triterpenoid in licorice roots, is a precursor of Glycyrrhetinic acid. β-Amyrenonol has anti-proliferative and anti-inflammatory activities, and β-Amyrenonol could function as the skeleton for the synthesis of many triterpenoids.

HY-108034

GET73	Others	Neurological Disease
GET73 is a γ-hydroxybutyric acid (GHB) analog, a naturally occurring neurotransmitter. GET73 has anti-alcohol and anxiolytic properties. GET73 significantly affects glutamate transmission in the hippocampus.

HY-108529

BMS493	RAR/RXR	Metabolic Disease
BMS493 is an inverse pan-retinoic acid receptor (RAR) agonist. BMS493 increases nuclear corepressor interaction with RARs. BMS493 also could prevent retinoic acid-induced differentiation.

HY-14874

Topiroxostat FYX-051	Xanthine Oxidase Cytochrome P450	Metabolic Disease
Topiroxostat (FYX-051) is a potent and orally active xanthine oxidoreductase (XOR) inhibitor with an IC₅₀ value of 5.3 nM and a K_i value of 5.7 nM. Topiroxostat exhibits weak CYP3A4-inhibitory activity (18.6%). Topiroxostat has the potential for hyperuricemia treatment.

HY-136540

Resolvin D3 RvD3	Others	Inflammation/Immunology
Resolvin D3 (RvD3) is a docosahexaenoic acid (DHA) derived mediator. Resolvin D3 is dysregulated in arthritis and reduces arthritic inflammation.

HY-126995

Glycohyodeoxycholic acid	Endogenous Metabolite	Metabolic Disease
Glycohyodeoxycholic acid is a major metabolite of Hyodeoxycholic acid in humans. Glycohyodeoxycholic acid has preventative effects on gallstone formation.

HY-12598A

DHPG (RS)-3,5-DHPG	mGluR	Neurological Disease
DHPG ((RS)-3,5-DHPG) is an amino acid, which acts as a selective and potent agonist of group I mGluR (mGluR 1 and mGluR 5), shows no effect on Group II or Group III mGluRs. DHPG ((RS)-3,5-DHPG) is also an effective antagonist of mGluRs linked to phospholipase D.

HY-15079

Talampanel GYKI-53773; LY-300164	iGluR	Neurological Disease
Talampanel (LY300164) is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor antagonis with anti-seizure activity. Talampanel (IVAX) has neuroprotective effects in rodent stroke models. Talampanel attenuates caspase-3 dependent apoptosis in mouse brain.

HY-P1746

Protein Kinase C (19-31) PKC (19-31)	PKC	Inflammation/Immunology
Protein Kinase C (19-31), a peptide inhibitor of protein kinase C (PKC), derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31) with a serine at position 25 replacing the wild-type alanine, is used as protein kinase C substrate peptide for testing the protein kinase C activity. Protein kinase C (PKC) is involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins.

HY-16969

Dihexa PNB-0408; N-hexanoic-Try-Ile-(6)-Amino hexanoic amide; Hexanoyl-Tyr-Ile-Ahx-NH2	c-Met/HGFR	Neurological Disease
Dihexa, an oligopeptide drug, is an orally active and blood-brain barrier-permeable angiotensin IV analog. Dihexa binds to hepatocyte growth factor (HGF) with high affinity (K_d=65 pM) and potentiates its activity at its receptor, c-Met. Dihexa exhibits excellent antidementia activity and improves cognitive function in animal models. Dihexa may have therapeutic potential as a treatment Alzheimer’s disease.

HY-P1746A

Protein Kinase C (19-31) (TFA) PKC (19-31) (TFA)	PKC	Inflammation/Immunology
Protein Kinase C (19-31) TFA, a peptide inhibitor of protein kinase C (PKC), derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31) with a serine at position 25 replacing the wild-type alanine, is used as protein kinase C substrate peptide for testing the protein kinase C activity. Protein kinase C (PKC) TFA is involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins.

HY-113259

7α-Hydroxy-4-cholesten-3-one	Endogenous Metabolite	Metabolic Disease
7α-Hydroxy-4-cholesten-3-one is an intermediate in synthesis of bile acids from cholesterol. 7α-Hydroxy-4-cholesten-3-one is a pregnane X receptor (PXR) agonist. 7α-Hydroxy-cholest-4-en-3-one is a biomarker for bile acid loss, irritable bowel syndrome, and other diseases associated with defective bile acid biosynthesis. 7α-Hydroxy-cholest-4-en-3-one is the physiological substrate for CYP8B1.

HY-15209

Repaglinide
AG-EE 623ZW
Others Metabolic Disease

Repaglinide is an insulin secretagogue for the treatment of type-2 diabetes mellitus.

HY-N0728

α-Linolenic acid	PI3K Akt	Cancer Cardiovascular Disease
α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer.

HY-135425

10,12-Tricosadiynoic acid	Acyltransferase	Metabolic Disease
10,12-Tricosadiynoic acid is a highly specific, selective, high affinity and orally active acyl-CoA oxidase-1 (ACOX1) inhibitor. 10,12-Tricosadiynoic acid can treat high fat diet- or obesity-induced metabolic diseases by improving mitochondrial lipid and ROS metabolism.

HY-135772

12-Ketodeoxycholic acid	Endogenous Metabolite	Metabolic Disease
12-Ketodeoxycholic acid is a bile acid, metabolite from kidney. 12-Ketodeoxycholic acid can be a detectable marker for evidence of kidney injury

HY-103138A

(Rac)-WAY-161503	5-HT Receptor	Metabolic Disease Neurological Disease
(Rac)-WAY-161503 is a potent, selective, highly affinity 5-HT_2C receptor agonist with a K_i of 4 nM and an EC₅₀ of 12 nM. (Rac)-WAY-161503 displays higher affinity for 5-HT_2C than 5-HT_2A and 5-HT_2B receptors. (Rac)-WAY-161503 has anti-obesity and antidepressant effects.

HY-Y0445A

Sodium dichloroacetate	PDHK Reactive Oxygen Species NKCC Apoptosis	Cancer
Sodium dichloroacetate is a metabolic regulator in cancer cells' mitochondria with anticancer activity. Sodium dichloroacetate inhibits PDHK, resulting in decreased lactic acid in the tumor microenvironment. Sodium dichloroacetate increases reactive oxygen species (ROS) generation and promotes cancer cell apoptosis. Sodium dichloroacetate also works as NKCC inhibitor.

HY-121450

Lavoltidine Loxtidine; AH-234844	Histamine Receptor	Cancer
Lavoltidine (Loxtidine) is an an orally active, irreversible and highly potent histamine H2-receptor antagonist. Lavoltidine strongly inhibits gastric acid secretion and also induces hypergastrinemia.

HY-N0121

Sesamin	Others	Neurological Disease
Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia.

HY-N7062

JNJ-1661010 Takeda-25	FAAH	Neurological Disease
JNJ-1661010 (Takeda-25) a potent and selective fatty acid amide hydrolase (FAAH) inhibitor with IC₅₀s of 34 and 33 nM for rat FAAH and human FAAH, respectively. JNJ-1661010 can cross the blood-brain barrier and used as broad-spectrum analgesics.

HY-135808

BIZ 114	NF-κB	Inflammation/Immunology
BIZ 114 (Example 11) is a fatty acid derivative and potent inhibits the TNF-α activated NF-κΒ pathway. BIZ 114 has the potential to prevent and / or treat ophthalmic disorders such as retinal degenerative disorders and ocular inflammatory diseases.

HY-126327

UNC4976	Histone Methyltransferase	Cancer
UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids. UNC4976 simultaneously antagonizes H3K27me3-specific recruitment of CBX7 to target genes while increasing non-specific binding to DNA and RNA.

HY-W040055

D-(+)-Neopterin 2-Amino-6-((1S,2R)-1,2,3-trihydroxypropyl)pteridin-4(3H)-one	Endogenous Metabolite	Inflammation/Immunology
D-(+)-Neopterin, a catabolic product of guanosine triphosphate (GTM), serves as a marker of cellular immune system activation.

HY-W000434

Fmoc-NH-PEG4-CH2CH2COOH Fmoc-15-Amino-4,7,10,13-tetraoxapentadecanoic acid	ADC Linker	Cancer
Fmoc-NH-PEG4-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-N0548

α-Angelica lactone	Gutathione S-transferase	Cancer
α-Angelica lactone is a naturally occurring anticarcinogen and an vinylogous nucleophile. α-Angelica lactone can give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic trapping at the γ-carbon. α-Angelica lactone exerts strong chemoprotective effects by selective enhancement of glutathione-S-thansferase (GST) and UDP-glucononosyltransferase (UGT) detoxification enzymes.

HY-P1854

β-Amyloid (1-9)	Amyloid-β	Neurological Disease
β-Amyloid (1-9), an N-terminal fragment of beta amyloid, consists of amino acid residues 1 to 9. β-Amyloid (1-9) contains a B cell epitope, but it does not include T cell epitopes. Omission of residues 1 to 9 from the full-length Alzheimer'sβ-Amyloid peptide 1 to 40 does not prevent the peptide from forming amyloid fibrils or eliminate fibril polymorphism .

HY-B1716

L-5-Hydroxytryptophan L-5-HTP; Oxitriptan	Endogenous Metabolite	Metabolic Disease Neurological Disease
L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist. L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia.

HY-W011727A

Pyridoxal 5'-phosphate monohydrate Pyridoxal phosphate monohydrate	Others	Neurological Disease
Pyridoxal 5'-phosphate hydrate, the active form of vitamin B6, is an essential cofactor for multiple enzymes, including aromatic l-amino acid decarboxylase that catalyzes the final stage in the production of the neurotransmitters dopamine and serotonin. Pyridoxal 5'-phosphate hydrate is the most important coenzyme variant in the process of vitamin B6 intracellular phosphorylation and is interconvertible with other variants, including pyridoxine 5′‐phosphate (PNP) and pyridoxamine 5′‐phosphate (PMP).

HY-P1280

Margatoxin	Potassium Channel	Neurological Disease
Margatoxin, an alpha-KTx scorpion toxin, is a high affinity inhibitor of Kv1.3 (K_d=11.7 pM). Margatoxin inhibits the Kv1.2 (K_d=6.4 pM) and Kv1.1 (K_d=4.2 nM). Margatoxin, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research.

HY-N2453

Convallatoxin	PPAR NF-κB P-glycoprotein	Cancer Inflammation/Immunology
Convallatoxin is a cardiac glycoside isolated from Adonis amurensis Regel et Radde. Convallatoxin ameliorates colitic inflammation via activation of PPARγ and suppression of NF-κB. Convallatoxin is a P-glycoprotein (P-gp) substrate and recognized Val982 as an important amino acid involved in its transport. Convallatoxin is an enhancer of ligand-induced MOR endocytosis with high potency and efficacy. Anti-inflammatory and anti-proliferative properties.

HY-P1136

Gap19	Gap Junction Protein	Cardiovascular Disease
Gap19, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 has protective effects against myocardial.

HY-N7426

3-Deoxyglucosone 3-Deoxy-D-glucosone	Others	Metabolic Disease
3-Deoxyglucosone (3-Deoxy-D-glucosone) is a reactive intermediate of the Maillard reaction and the polyol pathway. 3-Deoxyglucosone rapidly reacts with protein amino groups to form advanced glycation end products (AGEs), such as imidazolone, it is the most specific AGE for 3-DG. 3-Deoxyglucosone synergizes with low glucose to potentiate GLP-1 secretion and is considered as a biomarker for diabetes.

HY-125801

3-Oxo-5β-cholanoic acid Dehydrolithocholic acid; 3-oxoLCA	ROR	Inflammation/Immunology
3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid), a bile acid metabolite, inhibits the diferentiation of TH17 cells by directly binding to the key transcription factor RORγt (K_d=1.13 μM).

HY-N7059

Lactobionic acid	Bacterial	Infection
Lactobionic acid is a bionic acid naturally found in the Caspian Sea yogurt and chemically constituted of a gluconic acid bonded to a galactose. Lactobionic acid has antioxidant, antimicrobial, chelating, stabilizer, acidulant, and moisturizing properties.

HY-B2246

L-Carnitine hydrochloride (R)-Carnitine hydrochloride	Endogenous Metabolite	Metabolic Disease
L-Carnitine hydrochloride ((R)-Carnitine hydrochloride), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine hydrochloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine hydrochloride is an antioxidant. L-Carnitine hydrochloride can ameliorate metabolic imbalances in many inborn errors of metabolism.

HY-117549

Ibrolipim NO-1886	Others	Cardiovascular Disease
Ibrolipim (NO-1886) is an orally active lipoprotein lipase (LPL)-promoting agent. Ibrolipim decreases plasma triglycerides, increases high-density lipoprotein cholesterol levels. Ibrolipim has renoprotective and hypolipidemic effects.

HY-126015

P053	Acyltransferase	Metabolic Disease
P053 is a potent, non-competitive and selective ceramide synthase 1 (CerS1) inhibitor wirh an IC₅₀ of 0.5 μM. P053 acts as an endogenous inhibitor of mitochondrial fatty acid oxidation in muscle. Whole-body adiposity regulator.

HY-107412

Proteasome inhibitor IX PS-IX; AM114	Proteasome	Cancer
Proteasome inhibitor IX (PS-IX; AM114) is a Chalcone derivative and a chymotrypsin-like activity of the 20S proteasome inhibitor with an IC₅₀ value of ~1 μM. Proteasome inhibitor IX exhibits HCT116 p53^+/+ cells growth inhibitory activity with an IC₅₀ value of 1.49 μM. Proteasome inhibitor IX has potent anticancer activity.

HY-112942A

*CMP-Sialic acid* sodium salt** CMP-Neu5Ac sodium salt	Others	Metabolic Disease
CMP-Sialic acid sodium salt (CMP-Neu5Ac sodium salt) is an allosteric inhibitor of UDP-GlcNAc 2-epimerase, the enzyme that initiates sialic acid synthesis. CMP-Sialic acid sodium salt provides a substrate for Golgi sialyltransferases.

HY-122337

Streptolydigin Portamycin	DNA/RNA Synthesis Bacterial	Infection
Streptolydigin (Portamycin) is a 3-acetyltetramic acid antibiotic and a potent bacterial RNA polymerase inhibitor with a K_i of 18 μM and a K_d of 15 μM. Streptolydigin inhibits RNA synthesis by binding to RNA polymerase and does not inhibit eukaryotic RNA polymerases. Streptolydigin possess potent antibacterial activity, particularly against anaerobes and some Gram-positive aerobes.

HY-115521

Jarin-1	Others	Others
Jarin-1 is a jasmonic acid-amido synthetase (JAR1) inhibitor with an IC₅₀ of 3.8 μM. Jarin-1 specific inhibits bioactive JA (jasmonoyl-isoleucine, JA-Ile) biosynthesis in Arabidopsis and other plants.

HY-136066

*Tauro-ω-muricholic acid* sodium** TωMCA sodium	Others	Metabolic Disease
Tauro-ω-muricholic acid sodium (TωMCA sodium) is a bile acid released by the liver and an analog of tauro-α-muricholic acid. Tauro-ω-muricholic acid sodium is investigated as a potential marker in plasma for early-onset neonatal sepsis (EOS) and cholestasis studies

HY-133027

Myristyl nicotinate Tetradecyl nicotinate	Others	Cancer
Myristyl nicotinate (Tetradecyl nicotinate) is an ester prodrug and a lipophilic derivative of Nicotinic acid. Myristyl nicotinate is being developed for delivery of Nicotinic acid into the skin for prevention of actinic keratosis and its progression to skin cancer. Myristyl nicotinate shows to stimulate epidermal differentiation in photodamaged skin, increasing skin NAD content and strengthening the skin barrier.

HY-14973

Vidupiprant AMG 853	Prostaglandin Receptor	Inflammation/Immunology
Vidupiprant (AMG 853) is a phenylacetic acid derivative. Vidupiprant is a potent and orally active CRTH2 (DP2) and prostanoid D receptor (DP or DP1) dual antagonist with IC₅₀s of 3 nM and 4 nM in buffer, and 8 nM and 35 nM in human plasma, respectively. Vidupiprant has the potential for asthma treatment.

HY-127090

Muramyl dipeptide MDP	p38 MAPK ERK JNK	Inflammation/Immunology
Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide is an inducer of bone formation through induction of Runx2. Muramyl dipeptide directly enhances osteoblast differentiation by up-regulating Runx2 gene expression through MAPK pathways. Muramyl dipeptide indirectly attenuates osteoclast differentiation through a decreased RANKL/OPG ratio.

HY-120355A

AP14145 hydrochloride	Potassium Channel	Cardiovascular Disease
AP14145 hydrochloride is a potent K_Ca2 (SK) channel negative allosteric modulator with an IC₅₀ of 1.1 μM for K_Ca2.2 (SK2) and K_Ca2.3 (SK3) channels. AP14145 hydrochloride inhibition strongly depends on two amino acids, S508 and A533 in the channel. AP14145 hydrochloride prolonged atrial effective refractory period (AERP) in rats and demonstrates antiarrhythmic effects in a Vernakalant-resistant porcine model of atrial fibrillation (AF).

HY-P1695

Cinnamycin Ro 09-0198	Bacterial Antibiotic
Cinnamycin is tetracyclic lantibiotic produced from S. cinnamoneus that contains four unusual amino acids: erythro-β-hydroxyaspartic acid, mesolanthionine, threo-β-methyllanthionine, and lysinoalanine.1 Cinnamycin has demonstrated antiviral activity against herpes simplex virus type 1 KOS strain infection in Vero cells via a cytopathic effect reduction assay. Cinnamycin recognizes the structure of phosphatidylethanolamine and forms an equimolar complex with the phospholipid on biological membranes. This peptide has been used as a probe for analyzing the transbilayer movement of phosphatidylethanolamine.

HY-P1136A

Gap19 TFA	Gap Junction Protein	Cardiovascular Disease
Gap19 TFA, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 TFA inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 TFA is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 TFA has protective effects against myocardial.

HY-W019870

Glufosinate ammonium	Others	Neurological Disease
Glufosinate ammonium, a phosphinic acid analogue of glutamic acid, is an herbicide which is converted by plant cells into PT (L-phosphinothricin). Glufosinate ammonium exerts neurotoxic activity.

HY-N2417

Stearyl glycyrrhetinate	Bacterial	Infection
Stearyl glycyrrhetinate, a major component in licorice extract, has a MIC against S. aureus strains of more than 256 mg/L. Stearyl glycyrrhetinate has antibacterial effects.

HY-N6036

*Ganoderic acid* F**	Others	Cancer
Ganoderic acid F is a ganoderic acid. Ganoderic acid F exhibits antitumor and antimetastatic activities through inhibition of angiogenesis and alteration of proteins involving cell proliferation and/or cell death, carcinogenesis, oxidative stress, calcium signaling, and endoplasmic reticulum stress.

HY-15870

SR 11302	Others	Cancer Inflammation/Immunology
SR 11302 is an activator protein-1 (AP-1) transcription factor inhibitor. SR 11302 is a retinoid that specifically inhibits AP-1 activity without activating the transcription of retinoic acid response element (RARE).

HY-109124

Taniborbactam VNRX-5133	Bacterial	Infection
Taniborbactam (VNRX-5133) is a reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor with IC₅₀s of 8-530 nM. Taniborbactam has IC₅₀s of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2. Taniborbactam is against Gram-negative bacteria.

HY-133552

RORγt Inverse agonist 10	ROR	Inflammation/Immunology
RORγt Inverse agonist 10 is a potent and orally bioavailable RORγt (retinoic acid receptor-related orphan nuclear receptor gamma t) inverse agonist, with an IC₅₀ of 51 nM. RORγt is a major transcription factor of genes related to psoriasis pathogenesis such as IL-17A, IL-22, and IL-23R

HY-W019870A

Glufosinate	Others	Neurological Disease
Glufosinate, a phosphinic acid analogue of glutamic acid, is a herbicide which is converted by plant cells into PT (L-phosphinothricin). Glufosinate exerts neurotoxic activity.

HY-50202A

Etomoxir sodium salt (R)-(+)-Etomoxir sodium salt	Apoptosis	Metabolic Disease Cancer
Etomoxir sodium salt ((R)-(+)-Etomoxir sodium salt) is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig.

HY-125469

ICA-105665 PF-04895162	Potassium Channel	Neurological Disease
ICA-105665 (PF-04895162) is a potent and orally active neuronal Kv7.2/7.3 and Kv7.3/7.5 potassium channels opener. ICA-105665 inhibits liver mitochondrial function and bile salt export protein (BSEP) transport (IC₅₀ of 311 μM). ICA-105665 can penetrate the blood-brain barrier and has antiseizure effects.

HY-109124A

Taniborbactam hydrochloride VNRX-5133 hydrochloride	Bacterial	Infection
Taniborbactam hydrochloride (VNRX-5133 hydrochloride) is a reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor with IC₅₀s of 8-530 nM. Taniborbactam hydrochloride has IC₅₀s of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2. Taniborbactam hydrochloride is against Gram-negative bacteria.

HY-N0301

Thiocolchicoside	GABA Receptor	Inflammation/Immunology Neurological Disease
Thiocolchicoside is a competitive γ-aminobutyric acid type A (GAB_AA) receptor antagonist and glycine receptor agonist in the central nervous system. Thiocolchicoside is a semisynthetic sulfur derivative of colchicoside. Thiocolchicoside is a muscle relaxant and has anti-inflammatory, and analgesic properties.

HY-110155

LM11A-31 dihydrochloride	Others	Neurological Disease
LM11A-31 dihydrochloride, a non-peptide p75^NTR (neurotrophin receptor p75) modulator, is an orally active and potent proNGF (nerve growth factor) antagonist. LM11A-31 dihydrochloride is an amino acid derivative with high blood-brain barrier permeability and blocks p75-mediated cell death. M11A-31 dihydrochloride reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression.

HY-116214

Cyprodinil	Fungal Androgen Receptor
Cyprodinil is an anilinopyrimidine broad-spectrum fungicide that inhibits the biosynthesis of methionine in phytopathogenic fungi. Cyprodinil inhibits mycelial cell growth of B. cinerea, P. herpotrichoides, and H. oryzae on amino acid-free media (IC₅₀s=0.44, 4.8, and 0.03 µM, respectively). Cyprodinil acts as an androgen receptor (AR) agonist (EC₅₀=1.91 µM) in the absence of the AR agonist DHT and inhibits the androgenic effect of DHT (IC₅₀=15.1 µM).

HY-Y1620

3-(3,4-Dimethoxyphenyl)propanoic acid	Others	Cardiovascular Disease
3-(3,4-Dimethoxyphenyl)propanoic acid is an orally active short-chain fatty acids (SCFAs). 3-(3,4-Dimethoxyphenyl)propanoic acid stimulates γ globin gene expression, erythropoiesis in vivo and is used for the β hemoglobinopathies and other anemias.

HY-N3848

Ermanin	Bacterial COX NO Synthase Influenza Virus	Infection Inflammation/Immunology Cardiovascular Disease
Ermanin is a flavonoid isolated from Tanacetum microphyllum. Ermanin potently inhibits iNOS, COX-2 activities, and inhibits platelet aggregation. Ermanin has anti-inflammatory, anti-tuberculous and anti-viral/bacterial properties.

HY-N7512

Asimilobine	Dopamine Receptor 5-HT Receptor Parasite	Cancer Infection
Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. Asimilobine is a dopamine biosynthesis inhibitor and a serotonergic receptor antagonist. Asimilobine shows an antimalarial and anti-cancer activity.

HY-14165

Veliflapon BAY X 1005; DG-031	FLAP Leukotriene Receptor	Inflammation/Immunology Cardiovascular Disease
Veliflapon (BAY X 1005; DG-031) is an orally active and selective 5-lipoxygenase activating protein (FLAP) inhibitor. Veliflapon inhibits the synthesis of the leukotrienes B4 and C4.

HY-109854A

(R)-Lisofylline (R)-Lisophylline	STAT	Metabolic Disease Inflammation/Immunology
(R)-Lisofylline ((R)-Lisophylline) is a (R)-enantiomer of the metabolite of Pentoxifylline with anti-inflammatory properties. (R)-Lisofylline is a lysophosphatidic acid acyltransferase inhibitor with an IC₅₀ of 0.6 µM and interrupts IL-12 signaling-mediated STAT4 activation. (R)-Lisofylline has the potential for type 1 diabetes, autoimmune disorders research.

HY-129388B

LSD1-IN-7 benzenesulfonate	Histone Demethylase	Cancer
LSD1-IN-7 benzenesulfonate is a potent and orally active inhibitor of lysine specific demethylase-1 (LSD1) with anticancer activity extracted from patent WO2017079670A1, compound 4-[2-(4-amino-piperidin-1-yl)-5-(3-fluoro-4-methoxy-phenyl)-1-methyl-6-oxo-1,6-dihydro-pyrimidin-4-yl]-2-fluorobenzonitrile.

HY-129388

LSD1-IN-7 Methylbenzenesulfonate	Histone Demethylase	Cancer
LSD1-IN-7 Methylbenzenesulfonate is a potent and orally active inhibitor of lysine specific demethylase-1 (LSD1) with anticancer activity extracted from patent WO2017079670A1, compound 4-[2-(4-amino-piperidin-1-yl)-5-(3-fluoro-4-methoxy-phenyl)-1-methyl-6-oxo-1,6-dihydro-pyrimidin-4-yl]-2-fluorobenzonitrile.

HY-N1429

*Taurochenodeoxycholic acid* sodium salt** 12-Deoxycholyltaurine sodium salt	Apoptosis Endogenous Metabolite	Inflammation/Immunology
Taurochenodeoxycholic acid sodium salt (12-Deoxycholyltaurine sodium salt) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid induces apoptosis and shows obvious anti-inflammatory and immune regulation properties.

HY-N2027

Taurochenodeoxycholic acid 12-Deoxycholyltaurine	Apoptosis Endogenous Metabolite	Inflammation/Immunology
Taurochenodeoxycholic acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid induces apoptosis and shows obvious anti-inflammatory and immune regulation properties.

HY-135880A

OMDM-4
Endogenous Metabolite Neurological Disease

OMDM-4 is a selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a K_i 17.7 μM.

HY-135882

OMDM-6	TRP Channel Cannabinoid Receptor Endogenous Metabolite	Neurological Disease
OMDM-6 is a hybrid agonist of vanilloid receptor type 1 (VR1, TRPV1) (EC₅₀=75 nM) and cannabinoid receptor type 1 (CB1) (K_i=3.2 μM). OMDM-6 inhibits anandamide cellular uptake (ACU) with a K_i of 7.0 μM.

HY-121557

OMDM-1
Endogenous Metabolite Neurological Disease

OMDM-1 is a potent, selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a K_i of 2.4 μM.

HY-135881

OMDM-5	TRP Channel Endogenous Metabolite	Neurological Disease
OMDM-5 is a selective inhibitor of anandamide cellular uptake (ACU), with a K_i of 4.8 μM. OMDM-5 is also a potent vanilloid receptor type 1 (VR1, TRPV1) agonist, with an EC₅₀ of 75 nM, and shows weakly active as cannabinoid receptor type 1 (CB1) ligand (K_i=4.9 μM).

HY-135880

OMDM-3
Endogenous Metabolite Neurological Disease

OMDM-3 is a selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a K_i of 16.6 μM.
HY-103342

OMDM-2
Endogenous Metabolite Neurological Disease

OMDM-2 is a potent, selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a K_i of 3.0 μM.

HY-112764

DMG-PEG 2000	Others	Metabolic Disease
DMG-PEG 2000 is used for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. DMG-PEG 2000 is also used for the lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modification to improve the mucus permeability and delivery efficiency of the nanoparticles.

HY-B1367

Carbenoxolone disodium	Gap Junction Protein	Infection Inflammation/Immunology
Carbenoxolone disodium is the active metabolite of Glycyrrhizic acid (HY-N0184) and the inhibitor of human 11β-HSD and bacterial 3α, 20β-HSD. Carbenoxolone disodium is an uncoupling agent for gap junctions and a potent inhibitor of Vaccinia virus replication. Carbenoxolone disodium is used for the study of peptic, esophageal and oral ulceration and inflammation.

Cat. No.	Product Name

HY-L0052V

Advanced Library 493,968 compounds

A unique collection contains 493,968 compounds that have lead-like properties for high-throughput screening (HTS) and high content screening (HCS).
HY-L0067V

Immuno-Oncology Library 52,935 compounds

A unique collection of 52,935 diverse compounds designed for discovery of novel hits in immuno-oncology therapeutic area has been offered.

HY-L012

Metabolism/Protease Compound Library

2018 compounds

Metabolism is the set of life-sustaining chemical reactions in organisms. Metabolic pathways are enzyme-mediated biochemical reactions that lead to biosynthesis (anabolism) or breakdown (catabolism) of natural product small molecules within a cell or tissue. Acting as catalysts, enzymes are crucial to metabolism - they allow a reaction to proceed more rapidly - and they also allow the regulation of the rate of a metabolic reaction. Proteases are used throughout an organism for various metabolic processes. Proteases control a great variety of physiological processes that are critical for life, including the immune response, cell cycle, cell death, wound healing, food digestion, and protein and organelle recycling. Imbalances in metabolic activities have been found to be critical in a number of pathologies, such as cardiovascular diseases, inflammation, cancer, and neurodegenerative diseases.

MCE designs a unique collection of 2018 Metabolism/Protease-related small molecules that act as a useful tool for drug discovery of metabolism-related diseases.

HY-L0079V

Glycomimetic Library	2,718 compounds
A specially synthesized set of 2,718 compounds able to mimic glycosides and their interaction with proteins. The main emphasis of library design was made on drug-like compounds enriched with H-bond donors (possess at least two H-bond donors) and bearing nature-like Fsp3–rich scaffolds with diverse spatial orientation of H-bond donors and different 3D-shapes.

HY-L007

Immunology/Inflammation Compound Library

1676 compounds

The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease. To function properly, an immune system must detect a wide variety of agents, known as pathogens, from viruses to parasitic worms, and distinguish them from the organism's own healthy tissue. Inflammation is also the body's attempt at self-protection to remove harmful stimuli and begin the healing process. It’s part of the body's immune response. The immune system recognizes damaged cells, irritants, and pathogens, and inflammation begins the healing process. Inflammatory abnormalities are a large group of disorders that underlie a vast variety of human diseases. The immune system is often involved with inflammatory disorders, demonstrated in both allergic reactions and some myopathies, with many immune system disorders resulting in abnormal inflammation.

MCE designs a unique collection of 1676 compounds that are useful tool for Immunology/Inflammation research or autoimmune inflammatory diseases drug discovery.

HY-L064

Glutamine Metabolism Compound Library

335 compounds

Glutamine is an important metabolic fuel that helps rapidly proliferating cells meet the increased demand for ATP, biosynthetic precursors, and reducing agents. Glutamine Metabolism pathway involves the initial deamination of glutamine by glutaminase(GLS), yielding glutamate and ammonia. Glutamate is converted to the TCA cycle intermediate α-ketoglutarate (α-KG) by either glutamate dehydrogenase (GDH) or by the alanine or aspartate transaminases (TAs), to produce both ATP and anabolic carbons for the synthesis of amino acids, nucleotides and lipids. During periods of hypoxia or mitochondrial dysfunction, α-KG can be converted to citrate in a reductive carboxylation reaction catalyzed by IDH2. The newly formed citrate exits the mitochondria where it is used to synthesize fatty acids and amino acids and produce the reducing agent, NADPH.

Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic mutations and loss of tumor suppressors. Mounting evidence indicates that altered glutamine metabolism in cancer cells has critical roles in supporting macromolecule biosynthesis, regulating signaling pathways, and maintaining redox homeostasis, all of which contribute to cancer cell proliferation and survival. Thus, intervention in glutamine metabolic processes could provide novel approaches to improve cancer treatment.

MCE owns a unique collection of 335 compounds targeting the mainly proteins and enzymes involved in glutamine metabolism pathway. Glutamine Metabolism compound library is a useful tool for intervention in glutamine metabolic processes.

HY-L024

Histone Modification Research Compound Library

343 compounds

A histone modification, a covalent post-translational modification (PTM) to histone proteins, includes methylation, phosphorylation, acetylation, ubiquitylation, and sumoylation, etc. In general, histone modifications are catalyzed by specific enzymes that act predominantly at the histone N-terminal tails involving amino acids such as lysine or arginine, as well as serine, threonine, tyrosine, etc. The PTMs made to histones can impact gene expression by altering chromatin structure or recruiting histone modifiers. Histone modifications act in diverse biological processes such as transcriptional activation/inactivation, chromosome packaging, and DNA damage/repair. Deregulation of histone modification contributes to many diseases, including cancer and autoimmune diseases.

MCE owns a unique collection of 343 bioactive compounds targeting Epigenetic Reader Domain, HDAC, Histone Acetyltransferase, Histone Demethylase, Histone Methyltransferase, Sirtuin, etc. Histone Modification Research Compound Library is a useful tool for histone modification research and drug screening.

Cat. No.	Product Name	Type

HY-117695

AQC 6-Aminoquinolyl-N-hydroxysccinimidyl carbamate	Fluorescent Dyes/Probes
AQC (6-Aminoquinolyl-N-hydroxysccinimidyl carbamate) is a reagent used in for amino acid or protein sequence analysis by HPLC with fluorescence detection. AQC reacts with primary and secondary amino acids to yield fluorescent derivates, allowing amino acid detection at under-picomolar levels.

HY-D0908

Ninhydrin
Dyes

Ninhydrin can be used as a chromogenic analytical probe for the quantification of amino acids and proteins.
HY-D0027

7-Amino-4-methylcoumarin
Coumarin 120; AMC
Fluorescent Dyes/Probes

7-amino-4-methylcoumarin (Coumarin 120) has been used as a fluorogenic probe for many serine proteases.

HY-D0981

*7-Amino-4-(trifluoromethyl)coumarin* Coumarin 151; AFC	Fluorescent Dyes/Probes
7-Amino-4-(trifluoromethyl)coumarin (Coumarin 151) is a fluorescent marker for the sensitive detection of proteinases. The excitation and emission wavelengths are 400 and 490 nm, respectively.

HY-D1049

DNP-X acid 6-((2,4-Dinitrophenyl)Amino)hexanoic acid	Fluorescent Dyes/Probes
DNP-X acid (6-((2,4-Dinitrophenyl)amino)hexanoic acid), an amine-reactive building block for developing a probe, can be recognized by anti-DNP antibodies. DNP-X acid is also an excellent amine-reactive FRET quencher paired with Trp or Tyr.

HY-101937B

L-ANAP hydrochloride
Fluorescent Dyes/Probes

L-ANAP hydrochloride is a genetically encodable and polarity-sensitive fluorescent unnatural amino acid (Uaa).
HY-D0785

NBD-F
4-Fluoro-7-nitrobenzofurazan
Fluorescent Dyes/Probes

NBD-F is a fluorescent derivatization reagent which is originally developed for amino acid analysis.
HY-101937

L-ANAP
Fluorescent Dyes/Probes

L-ANAP is a genetically encodable and polarity-sensitive fluorescent unnatural amino acid (Uaa).

HY-D0802

Biotin NHS Biotin-NHS; Biotin N-hydroxysuccinimide ester; NHS-Biotin	Fluorescent Dyes/Probes
Biotin NHS is an amino reactive biotin reagent used in the preparation of biotinylated surfaces or polypeptides.

HY-101937A

(±)-ANAP
Fluorescent Dyes/Probes

(±)-ANAP is the unnatural amino acid analog of prodan, acts as a fluorescent probes, and enhances environmental sensitivity.
HY-101937C

(±)-ANAP hydrochloride
Fluorescent Dyes/Probes

(±)-ANAP hydrochloride is the unnatural amino acid analog of prodan, acts as a fluorescent probes, and enhances environmental sensitivity.
HY-D0827

Cy2
Cyanine2
Protein Labeling

CY2 Non-Sulfonated (Cyanine2) is a dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides.
HY-D0042

NBD-Cl
NBD chloride
Dyes

NBD-Cl is a nonfluorescent reagent which becomes highly fluorescent after reaction with thiol or amino groups.
HY-D0925

Cy5.5-SE
Fluorescent Dyes/Probes

Cy5.5-SE is a cyanine dye, labeling amino-groups in peptides, proteins, and oligonucleotides.

HY-D0826

Cy2-SE (iodine) Cyanine2 Succinimidyl Ester (iodine)	Protein Labeling
CY2-SE (Cyanine2 Succinimidyl Ester) is a dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides.

HY-135414

Cyanine5 NHS ester chloride
Fluorescent Dyes/Probes

Cyanine5 NHS ester chloride is a red emitting fluorescent dye for labeling of amino-groups in peptides, proteins, and oligonucleotides.
HY-D0823

CY3-SE
Sulfo-Cy3 NHS ester; Sulfo-Cy3 NHS ester; Sulfo Cyanine3 NHS ester
Protein Labeling

CY3-SE (Sulfo-Cy3 NHS ester) is a reactive dye for the labeling of amino-groups in biomolecules.

HY-D1046

*Dabcyl acid, SE* Dabcyl, SE	Fluorescent Dyes/Probes
Dabcyl acid, SE is the amino-reactive form of Dabcyl acid (DABCYL), and widely used to prepare a variety of FRET-based probes that contain DABCYL.

HY-D1054

Cy2 (iodine) Cyanine2 (iodine)	Fluorescent Dyes/Probes
Cy2 is a cyanine dye used for labeling amino-groups in peptides, proteins, and oligonucleotides, with λ excitation of 488 nm and λ emission of 520 nm.

HY-D0820

CY5-YNE
Sulfo-Cyanine5-alkyne
Protein Labeling

CY5-YNE (Sulfo-Cyanine5-alkyne) is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides.

HY-D0017

Dansyl chloride DNSCl	Protein Labeling
Dansyl chloride is a reagent that reacts with primary amino groups in both aliphatic and aromatic amines to produce stable blue- or blue-green-fluorescent sulfonamide adducts.

HY-101890

Dabsyl chloride DABS-Cl	Protein Labeling
Dabsyl chloride is an amine derivatizing agent, able to give rise to stable products that can be easily monitored spectrophotometrically at 460 nm; Dabsyl chloride also used for labeling amino acids.

HY-112498

Cy3 NHS ester Cyanine3 NHS ester	Fluorescent Dyes/Probes
Cy3 NHS ester (Cyanine3 NHS ester) is a yellow emitting fluorescent dye for labeling amino-groups in biomolecules. Used to label soluble proteins, peptides, and oligonucleotides/DNA.

HY-D0853A

H-L-Photo-lysine hydrochloride	Fluorescent Dyes/Probes
H-L-Photo-lysine hydrochloride is a diazirine-containing lysine amino acid and is a photo-cross-linker. H-L-Photo-lysine hydrochloride can site-selective incorporated into proteins and is used to crosslink protein-protein interactions in vitro and in living cells. H-L-Photo-lysine hydrochloride acts as a UV light-activated photo-crosslinking probe.

HY-D0853

H-L-Photo-lysine	Fluorescent Dyes/Probes
H-L-Photo-lysine is a diazirine-containing lysine amino acid and is a photo-cross-linker. H-L-Photo-lysine can site-selective incorporated into proteins and is used to crosslink protein-protein interactions in vitro and in living cells. H-L-Photo-lysine acts as a UV light-activated photo-crosslinking probe.

HY-D0821

CY5

Sulfo-Cyanine5

Protein Labeling

Cy5 (Sulfo-Cyanine5) is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides. This dye requires small amount of organic co-solvent (such as DMF or DMSO) to be used in labeling reaction. This reagent is ideal for very cost-efficient labeling of soluble proteins, as well as all kinds of peptides and oligonucleotides. This reagent also works well in organic solvents for small molecule labeling. Excitation (nm):649, Emission (nm): 670.

HY-D0819

CY5-SE

Cy5 NHS Ester; Sulfo-Cyanine5 Succinimidyl Ester

Protein Labeling

Cy5-SE (Cy5 NHS Ester) is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides. This dye requires small amount of organic co-solvent (such as DMF or DMSO) to be used in labeling reaction. This reagent is ideal for very cost-efficient labeling of soluble proteins, as well as all kinds of peptides and oligonucleotides. This reagent also works well in organic solvents for small molecule labeling. Excitation (nm):649, Emission (nm): 670.

Cat. No.	Product Name	Type

HY-126944

2-Aminobenzanilide 2-Amino-N-phenylbenzamide	Biochemical Assay Reagents
2-Aminobenzamide is a neutral and stable compound used as fluorescent tag, numerously in Glycan analysis. 2-aminobenzamide acts as the starting material for several important reactions like Bargellini reaction as an competent ambident nucleophile. Specifically 2-aminobenzamide and its derivatives are used in the blood coagulation cascade.

HY-B1102

Evans Blue
Direct Blue 53; C.I. 23860
Cell Assay Reagents

Evans Blue is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT).

HY-19804A

Photo-lysine hydrochloride	Cell Assay Reagents
Photo-lysine hydrochloride, a new lysine-based photo-reactive amino acid, captures proteins that bind lysine post-translational modifications.

HY-19804

Photo-lysine
Photo lysine
Cell Assay Reagents

Photo-lysine, a new lysine-based photo-reactive amino acid, captures proteins that bind lysine post-translational modifications.

HY-B1295

*Citric acid* trilithium salt tetrahydrate** Lithium citrate tribasic tetrahydrate; Trilithium citrate tetrahydrate	Biochemical Assay Reagents
Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) is a pharmaceutical and construction material, used in HPLC gradient elution for quantitative amino acid analysis.

HY-135087

Caprylic/Capric Triglyceride	Biochemical Assay Reagents
Caprylic/Capric Triglyceride is the triglycerides and esters prepared from fractionated vegetable oil sources and fatty acids from coconuts and palm kernel oils. Caprylic/Capric Triglyceride possesses excellent oxidation stability. Caprylic/Capric Triglyceride is used as a food additive and used in cosmetics.

HY-B1684

Mebrofenin SQ 26962	Biochemical Assay Reagents
Mebrofenin (SQ 26962) is a type of iminodiacetic acid (IDA). Mebrofenin is available as a ready to use the kit for radio-labeling with Tc-99m. Tc-99m Mebrofenin, a diagnostic agent, is used for hepatobiliary imaging. Tc-99m Mebrofenin is the radiopharmaceutical of choice for the evaluation of hepatic function.

Cat. No.	Product Name	Target	Research Area

HY-P1310

VKGILS-NH2	Peptides	Inflammation/Immunology
VKGILS-NH2 is a reversed amino acid sequence control peptide for SLIGKV-NH2 (protease-activated receptor 2 (PAR2) agonist). VKGILS-NH2 has no effect on DNA synthesis in cells.

HY-P1310A

VKGILS-NH2 TFA	Peptides	Inflammation/Immunology
VKGILS-NH2 TFA is a reversed amino acid sequence control peptide for SLIGKV-NH2 (protease-activated receptor 2 (PAR2) agonist). VKGILS-NH2 TFA has no effect on DNA synthesis in cells.

HY-P0207

Endothelin-2 (49-69), human Endothelin-2 (human, canine); Human endothelin-2	Peptides	Cancer Cardiovascular Disease
Endothelin-2 (49-69), human (Endothelin-2 (human, canine)) is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

HY-P0207A

Endothelin-2 (49-69), human TFA Endothelin-2 (49-69) (human, canine) TFA; Human endothelin-2 TFA	Peptides	Cancer Cardiovascular Disease
Endothelin-2 (49-69), human (TFA) (Endothelin-2 (49-69) (human, canine) (TFA)) is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

HY-P1535

Secretin, porcine Porcine secretin acetate	Peptides	Inflammation/Immunology
Secretin, porcine (Porcine secretin acetate) is a 27-amino acid peptide, acting on pancreatic acinar cells and ductal epithelial cells stimulating the production of bicarbonate rich fluid.

HY-P1535A

Secretin, porcine TFA Porcine secretin TFA	Peptides	Inflammation/Immunology
Secretin, porcine TFA (Porcine secretin TFA) is a 27-amino acid peptide, acting on pancreatic acinar cells and ductal epithelial cells stimulating the production of bicarbonate rich fluid.

HY-P1374

SYSMEHFRWGKPS
Peptides Others

SYSMEHFRWGKPS is a 13-amino acid peptide.

HY-P1497

Bradykinin (1-3)	Bradykinin Receptor	Cardiovascular Disease Endocrinology
Bradykinin (1-3) is a 3-amino acid residue peptide. Bradykinin (1-3) is an amino-truncated Bradykinin peptide, cleaved by Prolyl endopeptidase.

HY-P2298

TAT-P4-(DATC5)2	Peptides	Neurological Disease
TAT-P4-(DATC5)2 is a high-affinity peptide inhibitor of the PICK1 (protein interacting with C kinase-1) PDZ domain, with a K_i of 1.7 nM. TAT-P4-(DATC5)2 attenuats the reinstatement of cocaine seeking in rats.

HY-P2298A

TAT-P4-(DATC5)2 TFA	Peptides	Neurological Disease
TAT-P4-(DATC5)2 TFA is a high-affinity peptide inhibitor of the PICK1 (protein interacting with C kinase-1) PDZ domain, with a K_i of 1.7 nM. TAT-P4-(DATC5)2 TFA attenuats the reinstatement of cocaine seeking in rats.

HY-P1227

SDV-Exendin-3/4
Peptides Metabolic Disease

SDV-Exendin-3/4 is a 32-amino acid peptide.
HY-P1232

HAE
Peptides Metabolic Disease

HAE is a 3-amino acid peptide which consists of histidine, alanine and glutamate.
HY-P1559

GRGDSPC
Peptides Cancer

GRGDSPC, a 7-amino acid peptide, is a thiolated cell adhesion peptide.

HY-P0198

Neuropeptide Y (29-64), amide, human Human neuropeptide Y (29-64)	Neuropeptide Y Receptor	Neurological Disease Endocrinology
Neuropeptide Y (29-64), amide, human is a biologically active 36-amino acid peptide.

HY-P0280

MUC5AC motif peptide
Peptides Cancer Inflammation/Immunology

MUC5AC motif peptide is a 16-amino acid fragment of mucin 5.
HY-P1559A

GRGDSPC TFA
Peptides Cancer

GRGDSPC TFA, a 7-amino acid peptide, is a thiolated cell adhesion peptide.
HY-P1541

Motilin, canine
Motilin (canine)
Peptides Metabolic Disease

Motilin, canine is a 22-amino acid peptide. Motilin is a potent agonist for gastrointestinal smooth muscle contraction.

HY-P1455

Adrenomedullin (AM) (1-52), human Human adrenomedullin-(1-52)-NH2	Peptides	Cancer
Adrenomedullin (AM) (1-52), human is a 52-amino acid peptide, which affects cell proliferation and angiogenesis in cancer.

HY-P1585

Gp100 (25-33), human	Peptides	Inflammation/Immunology
Gp100 (25-33), human is the amino acids 25-33 fragment of the human melanoma antigen. It is a 9-amino acid (AA) epitope restricted by H-2D^b and recognized by the T cells.

HY-P1164

Urotensin II (114-124), human	Urotensin Receptor	Cardiovascular Disease
Urotensin II (114-124), human, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14.

HY-P1144

Oxyntomodulin
Glucagon Receptor Metabolic Disease

Oxyntomodulin, a 37-amino acid peptide hormone, is a glucagon-like peptide 1 (GLP-1) receptor agonist.

HY-P1585A

Gp100 (25-33), human TFA	Peptides	Cancer
Gp100 (25-33), human TFA is the amino acids 25-33 fragment of the human melanoma antigen. It is a 9-amino acid (AA) epitope restricted by H-2D^b and recognized by the T cells.

HY-P1732

Transportan	Peptides	Cancer
Transportan is a 27 amino acid-long peptide containing 12 functional amino acids from the amino terminus of the neuropeptide galanin and mastoparan in the carboxyl terminus, connected via a lysine. Transportan belongs to cell-penetrating peptides (CPPs).

HY-P1164A

Urotensin II (114-124), human TFA	Urotensin Receptor	Cardiovascular Disease
Urotensin II (114-124), human TFA, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14.

HY-P1127

Galanin (1-30), human	Neuropeptide Y Receptor	Neurological Disease Endocrinology
Galanin (1-30), human is a 30-amino acid neuropeptide, and acts as an agonist of GalR1 and GalR2 receptors, with K_is of both 1 nM.

HY-P1373

Neuronostatin-13 human	Peptides	Neurological Disease
Neuronostatin-13 human is a 13-amino acid peptide hormone encoded by the somatostatin gene and plays an important role in the regulation of hormonal and cardiac function.

HY-P1144A

Oxyntomodulin TFA
Glucagon Receptor Metabolic Disease

Oxyntomodulin TFA, a 37-amino acid peptide hormone, is a glucagon-like peptide 1 (GLP-1) receptor agonist.
HY-P0259

Xenin
Peptides Metabolic Disease Neurological Disease

Xenin is a 25-amino acid peptide initially isolated from human gastric mucosa. Xenin is a gut hormone that can reduce food intake.

HY-P0204

Endothelin-3, human, mouse, rabbit, rat Endothelin 3 (Rat,Human)	Peptides	Neurological Disease Cardiovascular Disease
Endothelin-3, human, mouse, rabbit, rat is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

HY-P1465

Secretin (28-54), human Human secretin	Peptides	Metabolic Disease
Secretin (28-54), human is a 27-amino acid residue C-terminally amidated peptide, which acts on human secretin receptors.

HY-P0191

Charybdotoxin	Potassium Channel	Inflammation/Immunology
Charybdotoxin, a 37-amino acid peptide isolated from venom of the scorpion Leiurus quinquestriatus var. hebraeus, is a K⁺ channel blocker.

HY-P0279

Systemin
Peptides Others

Systemin, an 18-amino acid polypeptide, has been isolated from tomato leaves that is a powerful inducer of over 15 defensive genes.

HY-P1465A

Secretin (28-54), human TFA Human secretin TFA	Peptides	Metabolic Disease
Secretin (28-54), human TFA is a 27-amino acid residue C-terminally amidated peptide, which acts on human secretin receptors.

HY-P0191A

Charybdotoxin TFA	Potassium Channel	Inflammation/Immunology
Charybdotoxin TFA, a 37-amino acid peptide isolated from venom of the scorpion Leiurus quinquestriatus var. hebraeus, is a K⁺ channel blocker.

HY-P0204A

Endothelin-3, human, mouse, rabbit, rat TFA Endothelin 3 (Rat,Human) (TFA)	Peptides	Neurological Disease Cardiovascular Disease
Endothelin-3, human, mouse, rabbit, rat TFA is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

HY-P1863

α-Neoendorphin (1-8)	Peptides	Neurological Disease
α-Neoendorphin (1-8) is a 8-amino acid peptide derived from the N-terminal of α-Neoendorphin. α-Neoendorphin is an endogenous opioid peptide.

HY-P0324

Parasin I
Bacterial Infection

Parasin I is a 19-amino acid histone H2A-derived peptide isolated from the skin of the catfish, and shows antimicrobial activity.

HY-P0307A

Antennapedia Peptide(TFA)	Peptides	Cancer Inflammation/Immunology
Antennapedia Peptide is a 16 amino acid peptide, originally derived from the 60 amino acid long homeodomain of the Drosophila transcription factor Antennapedia and is a member of the family of Cell-penetrating peptides.

HY-P0307

Antennapedia Peptide	Peptides	Cancer
Antennapedia Peptide is a 16 amino acid peptide, originally derived from the 60 amino acid long homeodomain of the Drosophila transcription factor Antennapedia and is a member of the family of Cell-penetrating peptides.

HY-P0324A

Parasin I TFA
Bacterial Infection

Parasin I (TFA) is a 19-amino acid histone H2A-derived peptide isolated from the skin of the catfish, and shows antimicrobial activity.
HY-P0293

FMRF
Peptides Others

FMRF is a peptide consisting of 4 amino acid residues.
HY-P1157

Exendin derivative 1
Peptides Others

Exendin derivative 1 is a 39 amino acid peptide.
HY-112173

Prolylleucine
((Benzyloxy)carbonyl)-L-prolyl-D-leucine
Peptides Cardiovascular Disease

Prolylleucine is a dipeptide containing branched-chain amino acids.

HY-P1363

β-Amyloid (1-42), human TFA Amyloid β-Peptide (1-42) (human) TFA	Amyloid-β	Neurological Disease
β-Amyloid (1-42), human TFA (Amyloid β-Peptide (1-42) (human) TFA) is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.

HY-111922

H-Gly-Gly-Pro-OH
Glycyl-glycyl-L-proline
Peptides Others

H-Gly-Gly-Pro-OH is a peptide with 3 amino acid.

HY-P1070

Amylin, amide, human DAP amide, human	Peptides	Metabolic Disease
Amylin, amide, human, a 37-amino acid polypeptide, is a pancreatic hormone cosecreted with insulin that exerts unique roles in metabolism and glucose homeostasis. Amylin, amide, human inhibits glucagon secretion, delays gastric emptying, and acts as a satiety agent.

HY-P1348

GLP-1 moiety from Dulaglutide	Glucagon Receptor	Metabolic Disease
GLP-1 moiety from Dulaglutide is a 31-amino acid fragment of Dulaglutide which is a glucagon-like peptide 1 receptor (GLP-1) agonist, extracted from patent US 20160369010 A1.

HY-P1509

Rhodopsin Epitope Tag	Peptides	Neurological Disease
Rhodopsin Epitope Tag is a 9-amino acid peptide localized within the C-terminal region of bovine rhodopsin . Rhodopsin Epitope Tag is widely used as an epitope tag and can be recognized by a number of anti-rhodopsin antibodies.

HY-P1362

β-Amyloid (42-1), human Amyloid β Peptide (42-1)(human)	Amyloid-β	Neurological Disease
β-Amyloid (42-1), human is the inactive form of Amyloid β Peptide (1-42). Amyloid β Peptide (42-1) is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.

HY-P1871

Amylin (IAPP), feline	Peptides	Metabolic Disease
Amylin (IAPP), feline, a 37-amino acid polypeptide. Amylin (IAPP) is one of the major secretory products of β-cells of the pancreatic islets. Amylin (IAPP) is a regulatory peptide, which inhibits insulin and glucagon secretion.

HY-P1537

Pancreatic Polypeptide, bovine	Neuropeptide Y Receptor	Metabolic Disease Endocrinology
Pancreatic Polypeptide, bovine, a 36-amino acid, straight chain polypeptide derived primarily from the pancreas, inhibits secretin- and cholecystokinin-stimulated pancreatic secretion; Pancreatic Polypeptide, bovine acts as an agonist of NPY receptor, with high affinity at NPYR4.

HY-P1764

Secretoneurin, rat	Peptides	Neurological Disease
Secretoneurin, rat, a 33-amino acid polypeptide, is generated by proteolytic processing of secretogranin II (SgII). Secretoneurin, rat induces dopamine release in the rat striatum in vivo and in vitro, and it exerts a very strong chemotactic effect on monocytes and eosinophils but not on granulocytes.

HY-P0326

S Tag Peptide
Peptides Others

S Tag Peptide is a 15 amino acid peptide derived from RNase A.
HY-P1511

PACAP-Related Peptide (PRP), human
Peptides Neurological Disease

PACAP-Related Peptide (PRP), human is a 29 amino-acid region of the PACAP precursor protein.

HY-P1070A

Amylin, amide, human TFA DAP amide, human TFA	Peptides	Metabolic Disease
Amylin, amide, human TFA, a 37-amino acid polypeptide, is a pancreatic hormone cosecreted with insulin that exerts unique roles in metabolism and glucose homeostasis. Amylin, amide, human TFA inhibits glucagon secretion, delays gastric emptying, and acts as a satiety agent.

HY-P1235A

Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate	Endothelin Receptor	Cardiovascular Disease Endocrinology
Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. ANP (1-28) inhibits endothelin-1 secretion in a dose-dependent way.

HY-P1238

Neuromedin U, rat Neuromedin U (rat); Rat neuromedin U-23	Peptides	Neurological Disease
Neuromedin U, rat is a 23-amino acid brain-gut peptide. Neuromedin U (NMU), through its cognate receptor NMUR2 in the central nervous system, regulates several important physiological functions, including energy balance, stress response, and nociception.

HY-P1867

β-Amyloid (1-34)
Peptides Neurological Disease

β-Amyloid (1-34) is a β-Amyloid peptide consists of 34 amino acid.
HY-P1895

β-Amyloid (33-40)
Amyloid-β Neurological Disease

β-Amyloid (33-40) is a peptide consisting of amino acid of 33 to 40 of beta amyloid protein.
HY-P1595

CREBtide
PKA Metabolic Disease

CREBtide, a synthetic 13 amino acid peptide, has been reported as a PKA substrate.
HY-P1818

Neuropeptide Y (22-36)
Neuropeptide Y Receptor Neurological Disease Endocrinology

Neuropeptide Y (22-36), a 15 amino acid peptide, is a fragment of Neuropeptide Y.
HY-P1903

β-Amyloid (35-42)
Amyloid-β Neurological Disease

β-Amyloid (35-42) is a peptide consisting of amino acid of 35 to 42 of beta amyloid protein.
HY-P1898

β-Amyloid (13-27)
Peptides Neurological Disease

β-Amyloid (13-27) is a peptide consisting of amino acid of 13 to 27 of beta amyloid protein.

HY-P1841

Glucagon-Like Peptide (GLP) II, human	Endogenous Metabolite	Metabolic Disease
Glucagon-Like Peptide (GLP) II, human is a 33-amino acid peptide derived from the C-terminal of proglucagon and mainly produced by the intestinal L cells. Glucagon-Like Peptide (GLP) II, human stimulates intestinal mucosal growth and decreases apoptosis of enterocytes .

HY-P0122

iRGD peptide c(CRGDKGPDC)	Integrin	Cancer
iRGD peptide is a 9-amino acid cyclic peptide, triggers tissue penetration of drugs by first binding to av integrins, then proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1, and has tumor-targeting and tumor-penetrating properties.

HY-P1238A

Neuromedin U, rat TFA Neuromedin U (rat) (TFA); Rat neuromedin U-23 TFA	Peptides	Neurological Disease
Neuromedin U, rat TFA is a 23-amino acid brain-gut peptide. Neuromedin U (NMU), through its cognate receptor NMUR2 in the central nervous system, regulates several important physiological functions, including energy balance, stress response, and nociception.

HY-P1179

Guanylin(human)	Guanylate Cyclase Endogenous Metabolite	Cancer Endocrinology
Guanylin(human), a 15-amino acid peptide, is an endogenous intestinal guanylate cyclase activator. Guanylin(human) is mainly found in gastrointestinal tract which regulates electrolytead water transport in intestinal and renal epithelia through cyclic GMP-dependent mechanism.

HY-P1271

Catestatin	nAChR	Cardiovascular Disease
Catestatin is a 21-amino acid residue, cationic and hydrophobic peptide. Catestatin is an endogenous peptide that regulates cardiac function and blood pressure. Catestatin is a non-competitive nicotinic antagonist acting through nicotinic acetylcholine receptors (nAChRs) to inhibit catecholamine release.

HY-P1601

Neuropeptide Y(29-64)
Neuropeptide Y Receptor Neurological Disease Endocrinology

Neuropeptide Y(29-64) is a 36 amino acid peptide, a fragment of Neuropeptide Y.
HY-P1864

β-Casomorphin (1-3), amide
Peptides Metabolic Disease Neurological Disease

β-Casomorphin (1-3), amide is a peptide fragment of β-Casomorphin with 3 amino acid.

HY-P1179A

Guanylin(human) TFA	Guanylate Cyclase Endogenous Metabolite
Guanylin(human) TFA, a 15-amino acid peptide, is an endogenous intestinal guanylate cyclase activator. Guanylin(human) TFA is mainly found in gastrointestinal tract which regulates electrolytead water transport in intestinal and renal epithelia through cyclic GMP-dependent mechanism.

HY-P1593

Mini Gastrin I, human
Cholecystokinin Receptor Cancer Endocrinology

Mini Gastrin I, human is a shorter version of human gastrin, consists of amino acids 5-17 of the parent peptide.
HY-P1850

β-Amyloid (1-20)
Amyloid-β Neurological Disease

β-Amyloid (1-20) consists of amino acids 1 to 20 of beta amyloid protein.
HY-P1913

Calcitonin Gene Related Peptide (CGRP) II, rat
Peptides Neurological Disease

Calcitonin Gene Related Peptide (CGRP) II, rat is a neuropeptide with 37 amino acid.
HY-P1600

Tyr-Somatostatin-14
Peptides Others

Tyr-Somatostatin-14 is a customized peptide that adds a Tyrosine amino acid to Somatostatin-14.
HY-P0138

MART-1 (26-35) (human)
Peptides Inflammation/Immunology

MART-1 (26-35) (human) is amino acid residue 26 to 35 of MART-1 protein.
HY-P0173

Chlorotoxin(linear)
Peptides Cancer

Chlorotoxin(linear) is a linear 36 amino-acid peptide which can be used in Chlorotoxin related research.
HY-P0328

VSV-G Peptide
Peptides Infection

VSV-G Peptide is a 11 amino acid peptide derived from the Vesicular Stomatitis viral glycoprotein.

HY-P1235

Carperitide Atrial Natriuretic Peptide (ANP) (1-28), human, porcine	Endothelin Receptor	Cardiovascular Disease Endocrinology
Carperitide (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine) is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. Carperitide (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine) inhibits endothelin-1 secretion in a dose-dependent way.

HY-P1271A

Catestatin TFA	nAChR	Cardiovascular Disease
Catestatin TFA is a 21-amino acid residue, cationic and hydrophobic peptide. Catestatin TFA is an endogenous peptide that regulates cardiac function and blood pressure. Catestatin TFA is a non-competitive nicotinic antagonist acting through nicotinic acetylcholine receptors (nAChRs) to inhibit catecholamine release.

HY-P0316

TP508	Thrombin NO Synthase	Cardiovascular Disease
TP508 is a 23-amino acid nonproteolytic thrombin peptide that represents a portion of the receptor-binding domain of thrombin molecule. TP508 activates endothelial NO synthase (eNOS) and stimulates production of NO in human endothelial cells. TP508 activates endothelial cells and stem cells to revascularize and regenerate tissues.

HY-P0138A

MART-1 (26-35) (human) TFA
Peptides Others

MART-1 (26-35) (human) TFA is amino acid residue 26 to 35 of MART-1 protein.
HY-P1913A

Calcitonin Gene Related Peptide (CGRP) II, rat TFA
Peptides Neurological Disease

Calcitonin Gene Related Peptide (CGRP) II, rat (TFA) is a neuropeptide with 37 amino acid.

HY-P1593A

Mini Gastrin I, human TFA	Cholecystokinin Receptor	Cancer Endocrinology
Mini Gastrin I, human (TFA) is a shorter version of human gastrin, consists of amino acids 5-17 of the parent peptide.

HY-P1457

Adrenomedullin (AM) (13-52), human	Peptides	Cardiovascular Disease
Adrenomedullin (AM) (13-52), human is a 40 amino acid peptide, which acts as an endothelium-dependent vasodilator agent.

HY-P1531

γ-1-Melanocyte Stimulating Hormone (MSH), amide	Melanocortin Receptor	Metabolic Disease Endocrinology
γ-1-Melanocyte Stimulating Hormone (MSH), amide is a 11-amino acid peptide. γ-1-Melanocyte Stimulating Hormone (MSH) regulates sodium (Na⁺) balance and blood pressure through activation of the melanocortin receptor 3 (MC3-R).

HY-P1565

Transdermal Peptide TD 1 (peptide)	Na+/K+ ATPase	Inflammation/Immunology
Transdermal Peptide (TD 1 peptide) is a 11-amino acid peptide, binds toNa⁺/K⁺-ATPase beta-subunit (ATP1B1), and mainly interacts with the C-terminus of ATP1B1. Transdermal Peptide can enhance the transdermal delivery of many macromolecules.

HY-W008235

Fmoc-N-Me-Ala-OH
Peptides Others

Fmoc-N-Me-Ala-OH, an N-Fmoc-N-methyl amino acid, is available for the peptide-coupling reaction.
HY-P1493

Fibrinopeptide B, human
FPB,human
Peptides Inflammation/Immunology

Fibrinopeptide B, human is a 14-aa peptide, released from the amino-terminus of β-chains of fibrinogen by thrombin.

HY-P1484

Bradykinin (1-7) Bradykinin Fragment 1-7	Bradykinin Receptor	Cardiovascular Disease Endocrinology
Bradykinin (1-7) is an amino-truncated Bradykinin peptide. Bradykinin (1-7) is a metabolite of Bradykinin, cleaved by endopeptidase.

HY-W008558

Fmoc-N-Me-Leu-OH
Peptides Others

Fmoc-N-Me-Leu-OH, an N-Fmoc-N-methyl amino acid, is available for the peptide-coupling reaction.

HY-P0173A

Chlorotoxin	Chloride Channel	Cancer
Chlorotoxin is a 36 amino-acid peptide from the venom of the Israeli scorpion Leiurus quinquestriatus with anticancer activity. Chlorotoxin is a chloride channel blocker.

HY-P0316A

TP508 TFA	Thrombin NO Synthase	Cardiovascular Disease
TP508 TFA is a 23-amino acid nonproteolytic thrombin peptide that represents a portion of the receptor-binding domain of thrombin molecule. TP508 TFA activates endothelial NO synthase (eNOS) and stimulates production of NO in human endothelial cells. TP508 TFA activates endothelial cells and stem cells to revascularize and regenerate tissues.

HY-P1565A

Transdermal Peptide TFA TD 1 (peptide) (TFA)	Na+/K+ ATPase	Others
Transdermal Peptide TFA (TD 1 peptide TFA) is a 11-amino acid peptide, binds to Na⁺/K⁺-ATPase beta-subunit (ATP1B1), and mainly interacts with the C-terminus of ATP1B1. Transdermal Peptide TFA can enhance the transdermal delivery of many macromolecules.

HY-P1590

Tyrosine Protein Kinase JAK 2 Phospho-Tyr8, 9	Peptides	Cancer Inflammation/Immunology
Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9) is a peptide corresponding to amino acids 475 to 491 of mouse JAK2.

HY-P1311

RLLFT-NH2
Peptides Others

RLLFT-NH2 is a reversed amino acid sequence negative control peptide for TFLLR-NH2.

HY-P1534

Adrenomedullin (1-50), rat	CGRP Receptor	Cardiovascular Disease
Adrenomedullin (1-50), rat is a 50 amino acid peptide, which induces a selective arterial vasodilation via activation of CGRP1 receptor.

HY-P1490

Bradykinin (2-9) Des-Arg1-bradykinin	Bradykinin Receptor	Cardiovascular Disease Endocrinology
Bradykinin (2-9) is an amino-truncated Bradykinin peptide. Bradykinin (2-9) is a metabolite of Bradykinin, cleaved by Aminopeptidase P.

HY-P0129

PLP 139-151	Peptides	Inflammation/Immunology
PLP (139-151) is amino acid residue 139 to 151 of myelin proteolipid protein (PLP) used to induce experimental autoimmune encephalomyelitis (EAE).

HY-P1311A

RLLFT-NH2 TFA
Peptides Others

RLLFT-NH2 TFA is a reversed amino acid sequence negative control peptide for TFLLR-NH2.

HY-P1365

α-Conotoxin MII α-CTxMII	nAChR	Neurological Disease
α-Conotoxin MII (α-CTxMII), a 16-amino acid peptide from the venom of the marine snail Conus magus, potently blocks nicotinic acetylcholine receptors (nAChRs) composed of α3β2 subunits, with an IC₅₀ of 0.5 nM. α-Conotoxin MII (α-CTxMII) potently blocks β3-containing neuronal nicotinic receptors .

HY-P1469

Bradykinin (1-6)	Bradykinin Receptor	Cardiovascular Disease Endocrinology
Bradykinin (1-6) is an amino-truncated Bradykinin peptide. Bradykinin (1-6) is a stable metabolite of Bradykinin, cleaved by carboxypeptidase Y (CPY).

HY-P1794

G280-9
Peptides Cancer

G280-9 is a 9 amino acid native epitope peptide. G280-9 is a relevant target expressed on melanoma.

HY-P1462

Calcitonin Gene Related Peptide (CGRP) (83-119), rat	CGRP Receptor	Neurological Disease
Calcitonin Gene Related Peptide (CGRP) (83-119), rat is a 37 amino acid calcitonin family of neuropeptide, acts through calcitonin receptor-like receptor (CRLR).

HY-P1916

FliC, Serotype a (427-441), S.paratyphi A	Peptides	Infection Inflammation/Immunology
FliC, Serotype a (427-441), S.paratyphi A is amino acids 427 to 441 fragment belongs to the FliC, serotype a of the S. FliC epitope.

HY-P1800

Caerulein, desulfated	Peptides	Metabolic Disease
Caerulein, desulfated is the desulfurated form of Caerulein. Caerulein is a decapeptide having the same five carboxyl-terminal amino acids as gastrin and cholecystokinin (CCK).

HY-P1365A

α-Conotoxin MII TFA α-CTxMII TFA	nAChR	Neurological Disease
α-Conotoxin MII TFA (α-CTxMII TFA), a 16-amino acid peptide from the venom of the marine snail Conus magus, potently blocks nicotinic acetylcholine receptors (nAChRs) composed of α3β2 subunits, with an IC₅₀ of 0.5 nM. α-Conotoxin MII TFA (α-CTxMII TFA) potently blocks β3-containing neuronal nicotinic receptors .

HY-P1924

Interphotoreceptor retinoid-binding protein(668-687) IRBP(668-687)	Peptides	Inflammation/Immunology
Interphotoreceptor retinoid-binding protein(668-687), the amino acid residues 668 to 687 of human interphotoreceptor retinoid binding protein (IRBP), induces uveitis.

HY-P1493A

Fibrinopeptide B, human TFA FPB,human TFA	Peptides	Inflammation/Immunology
Fibrinopeptide B, human TFA (FPB,human TFA), human is a 14-aa peptide, released from the amino-terminus of β-chains of fibrinogen by thrombin.

HY-P1462A

Calcitonin Gene Related Peptide (CGRP) (83-119), rat TFA	CGRP Receptor	Neurological Disease
Calcitonin Gene Related Peptide (CGRP) (83-119), rat (TFA) is a 37 amino acid calcitonin family of neuropeptide, acts through calcitonin receptor-like receptor (CRLR).

HY-P2193

TAT-amide
Peptides Infection

TAT-amide is a cell penetrating peptide. Cell-penetrating peptides (CPPs) are short amino acid sequences able to enter different cells.

HY-P1800A

Caerulein, desulfated TFA	Peptides	Metabolic Disease
Caerulein, desulfated TFA is the desulfurated form of Caerulein. Caerulein is a decapeptide having the same five carboxyl-terminal amino acids as gastrin and cholecystokinin (CCK).

HY-P1843

Glycoprotein (276-286)	Peptides	Infection
Glycoprotein (276-286) is a Db-restricted peptide derived from lymphocytic choriomeningitis virus (LCMV) glycoprotein (GP), corresponds to amino acids 276-286.

HY-P0312

c-Myc Peptide Trifluoroacetate	Peptides	Cancer
c-Myc Peptide Trifluoroacetate is a synthetic peptide corresponding to the C-terminal amino acids (410-419) of human c-myc protein, and participates in regulation of growth-related gene transcription.

HY-P1750

Shepherdin (79-87)	HSP Survivin	Cancer
Shepherdin (79-87) is amino acids 79 to 87 fragment of Shepherdin. Shepherdin is a peptidomimetic antagonist of the complex between Hsp90 and Survivin. Anticancer activity.

HY-P1170

N-terminally acetylated Leu-enkephalin Ac-L-Tyr-Gly-Gly-L-Phe-D-Leu-COOH	Opioid Receptor	Neurological Disease
N-terminally acetylated Leu-enkephalin is the N-terminally acetylated form of Leu-enkephalin. Leu-enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.

HY-P1749

Influenza HA (307-319)	Influenza Virus	Infection
Influenza HA (307-319) is 13 amino acids 307 to 319 fragment of Influenza HA. Influenza HA is a glycoprotein found on the surface of influenza viruses.

HY-P1071A

α-CGRP(human) TFA	Peptides	Cardiovascular Disease
α-CGRP(human) is a regulatory neuropeptide of 37 amino acids. α-CGRP(human) is widely distributed in the central and peripheral nervous system. α-CGRP(human) is a potent vasodilator.

HY-P1837

Influenza HA (518-526)
Peptides Infection

Influenza HA (518-526) is an H-2K^d-restricted epitope of the influenza virus hemagglutinin comprised amino acids 533 to 541.

HY-P1924A

Interphotoreceptor retinoid-binding protein(668-687) TFA IRBP(668-687) TFA	Peptides	Inflammation/Immunology
Interphotoreceptor retinoid-binding protein(668-687) TFA, the amino acid residues 668 to 687 of human interphotoreceptor retinoid binding protein (IRBP), induces uveitis.

HY-P1790

Axltide
Peptides Metabolic Disease

Axltide is based on the mouse Insulin receptor substrate 1 (amino acid 979-989). Axltide is a substrate for Axl, DDR2, Mst1, and JAK2 kinases.
HY-P1899

Smcy HY Peptide (738-746)
Peptides Inflammation/Immunology

Smcy HY Peptide (738-746) is a H2-D^b-restricted peptide corresponding to amino acids 738-746 of Smcy protein.
HY-P2193A

TAT-amide TFA
Peptides Infection

TAT-amide TFA is a cell penetrating peptide. Cell-penetrating peptides (CPPs) are short amino acid sequences able to enter different cells.

HY-P0064

Palmitoyl Tetrapeptide-3 Rigin	Peptides	Inflammation/Immunology
Palmitoyl Tetrapeptide-3 (Rigin) is a synthetic peptide, corrspending to 341-344 amino acid sequence of IgG human H-chain, with phagocytosis stimulating activity.

HY-P1071

α-CGRP(human)	Peptides	Cardiovascular Disease
α-CGRP(human) is a regulatory neuropeptide of 37 amino acids. α-CGRP(human) is widely distributed in the central and peripheral nervous system. α-CGRP(human) is a potent vasodilator.

HY-P1736

Influenza HA (126-138)	Peptides	Infection
Influenza HA (126-138) is a influenza virus hemagglutinin (HA) peptide comprising amino acids 126-138, induces thymic and peripheral T-cell apoptosis.

HY-P0288

[Leu5]-Enkephalin Leu-enkephalin; Leucine enkephalin; Leucyl-enkephalin	Opioid Receptor Endogenous Metabolite	Neurological Disease
[Leu5]-Enkephalin is a pentapeptides with morphine like properties. [Leu5]-Enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.

HY-P0199

Pancreatic Polypeptide, human Human pancreatic polypeptide	Neuropeptide Y Receptor	Metabolic Disease Endocrinology
Pancreatic Polypeptide, human is a C-terminally amidated 36 amino acid peptide, which acts as a neuropeptide Y (NPY) Y4/Y5 receptor agonist.

HY-P0223

FLAG peptide	Peptides	Inflammation/Immunology
FLAG peptide is an eight amino acids peptide (Asp-Tyr-Lys-Asp-Asp-Asp-Asp-Lys) with an enterokinase-cleavage site; designed for antibody-mediated identification and purification of recombinant proteins.

HY-P1856

Proinsulin C-peptide (human)	Peptides	Metabolic Disease
Proinsulin C-peptide (human) is a 31-amino-acid peptide that links the A and B chains of proinsulin, ensuring its correct folding, which is biologically active and modulates cellular function .

HY-P1755

p53 (17-26)
MDM-2/p53 Cancer

p53 (17-26) is amino acids 17 to 26 fragment of p53. p53 (17-26) is mdm-2-binding domain.

HY-P0239

HA Peptide	Peptides	Inflammation/Immunology
HA Peptide (HA tag) is a nine amino acids peptide derived from the human influenza hemagglutinin (HA). It is extensively used to isolate, purify, detect, and track the protein of interest in cell biology and biochemistry.

HY-P1519B

Brain Natriuretic Peptide (1-32), rat acetate BNP (1-32), rat acetate	Angiotensin Receptor	Cardiovascular Disease
Brain Natriuretic Peptide (1-32), rat acetate (BNP (1-32), rat acetate) is a 32 amino acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of heart muscle cells (cardiomyocytes).

HY-P0292

GnRH-I	Peptides	Endocrinology
GnRH-I is a small 10 amino acid long peptide (decapeptide) from the hypothalamus, acts at the hypophysis to cause an increase in release of biologically active Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH) in the blood.

HY-P1519

Brain Natriuretic Peptide (1-32), rat BNP (1-32), rat	Angiotensin Receptor	Cardiovascular Disease
Brain Natriuretic Peptide (1-32), rat (BNP (1-32), rat) is a 32 amino acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of heart muscle cells (cardiomyocytes).

HY-P1901

Insulin alpha-chain (1-13)	Peptides	Metabolic Disease
Insulin alpha-chain (1-13) is a human leucocyte antigen (HLA)-DR4-restricted epitope comprising the first 13 amino acids of the insulin A-chain.

HY-P0285

Rabies Virus Glycoprotein	Peptides	Infection
Rabies Virus Glycoprotein is a 29-amino-acid cell penetrating peptide derived from a rabies virus glycoprotein that can cross the blood-brain barrier (BBB) and enter brain cells.

HY-P1512

Antioxidant peptide A	Peptides	Cancer
Antioxidant peptide A is a short peptide, which contains alternative aromatic or sulfur-containing amino acid. The side chains of Antioxidant peptide A are believed to contribute to strong radical scavenging activities of peptides in the cancer cell.

HY-P1796A

Gp100 (619-627) (acetate)	Peptides	Cancer
Gp100 (619-627) acetate is amino acids 619 to 627 fragment of human melanoma antigen glycoprotein 100 (gp100). Gp100 has been a widely studied target for melanoma immunotherapy.

HY-P1796

Gp100 (619-627)	Peptides	Cancer
Gp100 (619-627) is amino acids 619 to 627 fragment of human melanoma antigen glycoprotein 100 (gp100). Gp100 has been a widely studied target for melanoma immunotherapy.

HY-P1674A

Murepavadin TFA POL7080 TFA	Bacterial Antibiotic	Infection
Murepavadin (TFA), a 14-amino-acid cyclic peptide, is a highly potent, specific antibiotic for the treatment of bacterial infections caused by Pseudomonas aeruginosa. Murepavadin (TFA) targets the lipopolysaccharide transport portin D .

HY-P1847

IKKγ NBD Inhibitory Peptide	NF-κB	Cancer
IKKγ NBD Inhibitory Peptide is a NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region, which is shown to block TNF-alpha-induced NF-kB activation.

HY-P1886

Kv3, Channel Containing Protein (567-585)	Peptides	Neurological Disease
Kv3, Channel Containing Protein (567-585) corresponds to amino acids 567 to 585 fragment of the Kv3.1b channel containing protein. Kv3 channel protein is expressed by parvalbumin (PV)-containing pallidal neurons .

HY-P0285A

Rabies Virus Glycoprotein TFA	Peptides	Infection
Rabies Virus Glycoprotein (TFA) is a 29-amino-acid cell penetrating peptide derived from a rabies virus glycoprotein that can cross the blood-brain barrier (BBB) and enter brain cells.

HY-P1418

DPC-AJ1951	Thyroid Hormone Receptor	Endocrinology
DPC-AJ1951, a 14 amino acid peptide that acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR) , and characterized its activity in ex vivo and in vivo assays of bone resorption.

HY-P2360

G12 Ras 5-17	Peptides	Others
G12 (Ras 5-17) is a wild-type Ras peptide consisted of amino acids 5-17 (KLVVVGAGGVGKS). G12 can be used as a control of mutant Ras peptides studies (such V12).

HY-P2361A

S12 TFA
Peptides Others

G12 (Ras 5-17) is a wild-type Ras peptide consisted of amino acids 5-17 (KLVVVGAGGVGKS). G12 can be used as a control of mutant Ras peptides studies (such V12).

HY-P1512A

Antioxidant peptide A TFA	Peptides	Cancer
Antioxidant peptide A TFA is a short peptide, which contains alternative aromatic or sulfur-containing amino acid. The side chains of Antioxidant peptide A are believed to contribute to strong radical scavenging activities of peptides in the cancer cell.

HY-P0327

T7 Tag Peptide	Peptides	Others
T7 Tag Peptide is a 11 amino acid peptide derived from the T7 major capsid protein, and serves as a tag in many expression vectors that is based on the very efficient T7 RNA polymerase expression system.

HY-P1847A

IKKγ NBD Inhibitory Peptide TFA	NF-κB	Inflammation/Immunology
IKKγ NBD Inhibitory Peptide TFA is a NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region, which is shown to block TNF-alpha-induced NF-kB activation.

HY-P0256

Apamin Apamine	Potassium Channel	Inflammation/Immunology Neurological Disease
Apamin (Apamine) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca²⁺-activated K⁺ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity.

HY-P1418A

DPC-AJ1951 TFA	Thyroid Hormone Receptor	Endocrinology
DPC-AJ1951 TFA, a 14 amino acid peptide that acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR) , and characterized its activity in ex vivo and in vivo assays of bone resorption.

HY-P1781

Peptide C105Y	Peptides	Cancer
Peptide C105Y, a synthetic and cell-penetrating peptide based on the amino acid sequence corresponding to residues 359-374 of α1-antitrypsin, enhances gene expression from DNA nanoparticles.

HY-P2299

Protein E7(43-62)
Peptides Cancer

Protein E7(43-62) is an E7-derived peptide with anti-tumor effects (short peptide spanning the 43th to 62th amino acid residues in the E7 protein).

HY-P1770

Adrenomedullin (16-31), human	CGRP Receptor	Cardiovascular Disease
Adrenomedullin (16-31), human is amino acid residues 16-31 fragment of human adrenomedullin (hADM). Adrenomedullin has appreciable affinity for the CGRP1 receptor. Adrenomedullin (16-31), human possesses pressor activity in the systemic vascular bed of the rat, but not the cat.

HY-P1340A

[Ala11,D-Leu15]-Orexin B(human) TFA	Orexin Receptor (OX Receptor)	Neurological Disease
[Ala11,D-Leu15]-Orexin B(human) TFA is a potent and selective orexin-2 receptor (OX2) agonist. [Ala11,D-Leu15]-Orexin B(human) TFA shows a 400-fold selectivity for the OX2 (EC₅₀=0.13 nM) over OX1 (52 nM).

HY-P0253A

Xenopsin TFA	Peptides	Metabolic Disease
Xenopsin TFA, a neurotensin-like octapeptide from Xenopus laevis skin. Xenopsin TFA is an inhibitor of Tetragastrin stimulated gastric acid secretion.

HY-P0253

Xenopsin
Peptides Metabolic Disease

Xenopsin, a neurotensin-like octapeptide from Xenopus laevis skin. Xenopsin is an inhibitor of Tetragastrin stimulated gastric acid secretion.

HY-P1340

[Ala11,D-Leu15]-Orexin B(human)	Orexin Receptor (OX Receptor)	Neurological Disease
[Ala11,D-Leu15]-Orexin B(human) is a potent and selective orexin-2 receptor (OX2) agonist. [Ala11,D-Leu15]-Orexin B(human) shows a 400-fold selectivity for the OX2 (EC₅₀=0.13 nM) over OX1 (52 nM).

HY-P7060

NT 13 TPPT	iGluR	Neurological Disease
NT 13 (TPPT) is a tetrapeptide having the amino acid sequence L-threonyl-L-prolyl-L-prolyl-L-threonine amide. NT 13 is a partial N-methyl-D-aspartate receptor (NMDAR) agonist used in the study of depression, anxiety, and other related diseases.

HY-P2360A

G12 TFA Ras 5-17 TFA	Peptides	Others
G12 (Ras 5-17) TFA is a wild-type Ras peptide consisted of amino acids 5-17 (KLVVVGAGGVGKS). G12 TFA can be used as a control of mutant Ras peptides studies (such V12).

HY-P1849

JAG-1, scrambled	Peptides	Cardiovascular Disease
JAG-1, scrambled is a scrambled sequence of JAG-1. JAG-1, scrambled with a random sequence of the amino acids that are the same as the active fragment. JAG-1, scrambled usually used as a negative control.

HY-P2299A

Protein E7(43-62) TFA	Peptides	Cancer
Protein E7(43-62) TFA is an E7-derived peptide with anti-tumor effects (short peptide spanning the 43th to 62th amino acid residues in the E7 protein).

HY-P1885

HIV gag peptide (197-205)	Peptides	Infection
HIV gag peptide (197-205) is a H-2K^d-restricted epitope derived from the p24 portion of the HIV-1 gag protein, consists of amino acids 197-205 (AMQMLKETI).

HY-P1798

Platelet Factor 4 (58-70), human	Peptides	Cardiovascular Disease
Platelet Factor 4 (58-70), human, a peptide based on the amino acid sequence corresponding to residues 58-70 of platelet factor-4 (PF-4), contains the major heparin-binding domain, which is not sufficient for full antiangiogenic activity.

HY-P1714

Apraglutide FE 203799	Peptides	Metabolic Disease
Apraglutide (FE 203799), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, enhances adaptation and linear intestinal growth in a neonatal piglet model of short bowel syndrome with total resection of the ileum.

HY-P0256A

Apamin TFA Apamine TFA	Potassium Channel	Inflammation/Immunology Neurological Disease
Apamin TFA (Apamine TFA) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca²⁺-activated K⁺ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity.

HY-P2219

CGGRGD	Peptides	Cancer
CGGRGD, a RGD derivative with cysteine as its N-terminal, CGGRGD is synthesized via solid-phase peptide synthesis technique and the surface of PCL fibers is aminolysised by amino 2-cyanobenzothiazole followed by the addition of 2-cyanobenzothiazole (CBT).

HY-P0308

[Glu1]-Fibrinopeptide B	Peptides	Cardiovascular Disease
[Glu1]-Fibrinopeptide B is derived from fibrinopeptide B amino acid residues 1-14. Human fibrinopeptide B (hFpB), a thrombin-derived proteolytic cleavage product of the fibrinogen B beta-chain, to stimulate neutrophils (PMN), monocytes, and fibroblasts.

HY-P0221

PACAP (1-38), human, ovine, rat Pituitary Adenylate Cyclase Activating Polypeptide 38	Peptides	Neurological Disease
PACAP (1-38), human, ovine, rat is a neuropeptide with 38 amino acid residues. PACAP (1-38) binds to PACAP type I receptor, PACAP type II receptor VIP₁, and PACAP type II receptor VIP₂ with IC₅₀s of 4 nM, 2 nM, and 1 nM, respectively.

HY-P1900

SEB Domain (144-153)	Peptides	Infection
SEB Domain 144-153 is Staphylococcal Enterotoxin B domain amino acid residue 144-153. SEB Domain 144-153 inhibits transcytosis of multiple staphylococcal enterotoxins, SEA, SEE, and TSST-1. Staphylococcal enterotoxin B (SEB) is a toxin produced by Staphylococcus aureus.

HY-P1714A

Apraglutide TFA FE 203799 TFA	Peptides	Metabolic Disease
Apraglutide TFA (FE 203799 TFA), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, enhances adaptation and linear intestinal growth in a neonatal piglet model of short bowel syndrome with total resection of the ileum.

HY-P1904

Phe-Met-Arg-Phe Like Peptide, Snail Helix aspersa	Peptides	Neurological Disease
Phe-Met-Arg-Phe Like Peptide, Snail Helix aspersa is a FMRF-like peptide from visceral and somatic muscles of the snail Helix aspersa. FMRF (Phe-Met-Arg-Phe) is a neuropeptide peptide consisting of 4 amino acid residues.

HY-P1907

Human Papillomavirus (HPV) E7 protein (49-57)	Peptides	Cancer
Human Papillomavirus (HPV) E7 protein (49-57) is the H-2^d-restricted human papillomavirus (HPV) E7_49-57 epitope (short peptide spanning the 49th to 57th amino acid residues in the E7 protein).

HY-P1298

Sauvagine	CRFR	Endocrinology Neurological Disease Cardiovascular Disease
Sauvagine, a 40-amino-acid neuropeptide from the skin of the frog, is a mammalian CRF agonist. Sauvagine is effective at releasing ACTH from rat pituitary cells. Sauvagine possesses a number of pharmacological actions on diuresis, the cardiovascular system and endocrine glands.

HY-P0221A

PACAP (1-38), human, ovine, rat TFA Pituitary Adenylate Cyclase Activating Polypeptide 38 TFA	Peptides	Neurological Disease
PACAP (1-38), human, ovine, rat TFA is a neuropeptide with 38 amino acid residues. PACAP (1-38) binds to PACAP type I receptor, PACAP type II receptor VIP₁, and PACAP type II receptor VIP₂ with IC₅₀s of 4 nM, 2 nM, and 1 nM, respectively.

HY-P1900A

SEB Domain (144-153) (TFA)	Peptides	Infection
SEB Domain 144-153 TFA is Staphylococcal Enterotoxin B domain amino acid residue 144-153. SEB Domain 144-153 inhibits transcytosis of multiple staphylococcal enterotoxins, SEA, SEE, and TSST-1. Staphylococcal enterotoxin B (SEB) is a toxin produced by Staphylococcus aureus.

HY-P1293

Conantokin G	iGluR	Neurological Disease
Conantokin G, a 17-amino-acid peptide, is a potent, selective and competitive antagonist of N-methyl-D-aspartate (NMDA) receptors. Conantokin G inhibits NMDA-evoked currents in murine cortical neurons with an IC₅₀ of 480 nM. Conantokin G has neuroprotective properties.

HY-P2219A

CGGRGD TFA	Peptides	Cancer
CGGRGD TFA, a RGD derivative with cysteine as its N-terminal, CGGRGD TFA is synthesized via solid-phase peptide synthesis technique and the surface of PCL fibers is aminolysised by amino 2-cyanobenzothiazole followed by the addition of 2-cyanobenzothiazole (CBT).

HY-P1072

PHM-27 (human)	CGRP Receptor	Metabolic Disease Cardiovascular Disease
PHM-27 (human) is a human prepro-vasoactive intestinal polypeptide (27 amino acid). PHM-27 (human) is a potent the human calcitonin receptor agonist with an EC₅₀ of 11 nM. PHM-27 (human) efficiently enhances glucose-induced insulin secretion from beta cells by an autocrine mechanism.

HY-P1298A

Sauvagine TFA	CRFR	Endocrinology Neurological Disease Cardiovascular Disease
Sauvagine TFA, a 40-amino-acid neuropeptide from the skin of the frog, is a mammalian CRF agonist. Sauvagine TFA is effective at releasing ACTH from rat pituitary cells. Sauvagine TFA possesses a number of pharmacological actions on diuresis, the cardiovascular system and endocrine glands.

HY-P1777

IGF-I (24-41) Insulin-like Growth Factor I (24-41)	Peptides	Metabolic Disease Inflammation/Immunology
IGF-I (24-41) is amino acids 24 to 41 fragment of Insulin-like Growth Factor I (IGF-I). IGF-I is partly responsible for systemic GH activities although it possesses a wide number of own properties (anabolic, antioxidant, anti-inflammatory and cytoprotective actions).

HY-P1773

IGF-I (30-41) Insulin-like Growth Factor I (30-41)	Peptides	Metabolic Disease Inflammation/Immunology
IGF-I (30-41) is amino acids 30 to 41 fragment of Insulin-like Growth Factor I (IGF-I). IGF-I is partly responsible for systemic GH activities although it possesses a wide number of own properties (anabolic, antioxidant, anti-inflammatory and cytoprotective actions).

HY-P1777A

IGF-I (24-41) (TFA) Insulin-like Growth Factor I (24-41) (TFA)	Peptides	Metabolic Disease Inflammation/Immunology
IGF-I (24-41) (TFA) is amino acids 24 to 41 fragment of Insulin-like Growth Factor I (IGF-I). IGF-I is partly responsible for systemic GH activities although it possesses a wide number of own properties (anabolic, antioxidant, anti-inflammatory and cytoprotective actions).

HY-P1773A

IGF-I (30-41) (TFA) Insulin-like Growth Factor I (30-41) (TFA)	Peptides	Metabolic Disease Inflammation/Immunology
IGF-I (30-41) (TFA) is amino acids 30 to 41 fragment of Insulin-like Growth Factor I (IGF-I). IGF-I is partly responsible for systemic GH activities although it possesses a wide number of own properties (anabolic, antioxidant, anti-inflammatory and cytoprotective actions).

HY-P1293A

Conantokin G TFA	iGluR	Neurological Disease
Conantokin G TFA, a 17-amino-acid peptide, is a potent, selective and competitive antagonist of N-methyl-D-aspartate (NMDA) receptors. Conantokin G TFA inhibits NMDA-evoked currents in murine cortical neurons with an IC₅₀ of 480 nM. Conantokin G TFA has neuroprotective properties.

HY-P1911

CEF27, Epstein-Barr Virus BRLF-1 lytic (148-156)	Peptides	Infection
CEF27, Epstein-Barr Virus BRLF-1 lytic 148-156 corresponding to amino acids 148-156 of the BRLF1 protein. BRLF1 is a transcriptional activator that binds directly to a GC-rich motif present in some Epstein-Barr virus (EBV) lytic gene promoters.

HY-106224

Orexin A (human, rat, mouse)	Orexin Receptor (OX Receptor)	Neurological Disease
Orexin A human, rat, mouse, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A human, rat, mouse is a specific, high-affinity agonist for G-protein-coupled receptor OX1R. Orexin A human, rat, mouse has a role in the regulation of feeding behavior. Orexin A human, rat, mouse is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.

HY-P1306

Obestatin(rat)	GHSR	Inflammation/Immunology Cardiovascular Disease
Obestatin(rat), encoded by the Ghrelin gene, is a cpeptide, comprised of 23 amino acids. Obestatin(rat) suppresses food intake, inhibits jejunal contraction, and decreases body-weight gain. Obestatin is an endogenous ligand of G-protein coupled receptor 39 (GPR39). Obestatin(rat) has anti-inflammatory, anti-myocardial infarction and antioxidant activities.

HY-P1833

Egg Laying Hormone, aplysia	Peptides	Neurological Disease
Egg Laying Hormone, aplysia is a neuropeptide synthesized by the bag cell neurons, which contains 36 amino acids and can stimulate egglaying and ovulation in Aplysia via electrical discharge triggering of neurons. Egg-laying hormone of Aplysia induces a voltage-dependent slow inward current carried by Na' in an identified motoneuron.

HY-P1202A

CYN 154806 TFA	Somatostatin Receptor	Endocrinology
CYN 154806 TFA, a cyclic octapeptide, is a potent and selective somatostatin sst2 receptor antagonist, with pIC₅₀ values of 8.58, 5.41, 6.07, 5.76 and 6.48 for human recombinant sst2, sst1, sst3, sst4 and sst5 receptors respectively.

HY-P1202

CYN 154806	Somatostatin Receptor	Endocrinology
CYN 154806, a cyclic octapeptide, is a potent and selective somatostatin sst2 receptor antagonist, with pIC₅₀ values of 8.58, 5.41, 6.07, 5.76 and 6.48 for human recombinant sst2, sst1, sst3, sst4 and sst5 receptors respectively.

HY-P1838

Proadrenomedullin (45-92), human	Peptides	Cardiovascular Disease
Proadrenomedullin (45-92), human, a mid-regional fragment of proadrenomedullin (MR-proADM), comprises amino acids 45–92 of pre-proADM. Proadrenomedullin (45-92), human has a longer half-life, is relatively stable and is produced in equimolar amounts to adrenomedullin (ADM), making it a surrogate for plasma levels of ADM gene products.

HY-P1525

Melanin Concentrating Hormone, salmon MCH (salmon)	MCHR1 (GPR24)	Metabolic Disease Neurological Disease Cardiovascular Disease Endocrinology
Melanin Concentrating Hormone, salmon is a 19-amino-acid neuropeptide initially identified in the pituitary gland of teleost fish, which regulates food intake, energy balance, sleep state, and the cardiovascular system. Melanin-concentrating hormone is a ligand for an orphan G protein-coupled receptor (SLC-1/GPR24) and MCHR2.

HY-P1306A

Obestatin(rat) TFA	GHSR	Inflammation/Immunology Cardiovascular Disease
Obestatin(rat) TFA, encoded by the Ghrelin gene, is a cpeptide, comprised of 23 amino acids. Obestatin(rat) TFA suppresses food intake, inhibits jejunal contraction, and decreases body-weight gain. Obestatin is an endogenous ligand of G-protein coupled receptor 39 (GPR39). Obestatin(rat) TFA has anti-inflammatory, anti-myocardial infarction and antioxidant activities.

HY-106783

Polymyxin B nonapeptide	Bacterial Antibiotic	Infection
Polymyxin B nonapeptide is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue. Polymyxin B nonapeptide is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes.

HY-P1525A

Melanin Concentrating Hormone, salmon TFA MCH (salmon) (TFA)	MCHR1 (GPR24)	Metabolic Disease Neurological Disease Cardiovascular Disease Endocrinology
Melanin Concentrating Hormone, salmon TFA (MCH (salmon) TFA) is a 19-amino-acid neuropeptide initially identified in the pituitary gland of teleost fish, which regulates food intake, energy balance, sleep state, and the cardiovascular system. Melanin-concentrating hormone is a ligand for an orphan G protein-coupled receptor (SLC-1/GPR24) and MCHR2.

HY-P1855

HER2/neu (654-662) GP2	Peptides	Cancer
HER2/neu (654-662) GP2 is a nine amino acid peptide derived from the human epidermal growth factor receptor 2 (HER2/nue, 654–662), induces HLA-A2-restricted cytotoxic T lymphocytes (CTL) reactive to various epithelial cancers.

HY-106224A

Orexin A (human, rat, mouse) (TFA)	Orexin Receptor (OX Receptor)	Neurological Disease
Orexin A human, rat, mouse TFA, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A human, rat, mouse TFA is a specific, high-affinity agonist for G-protein-coupled receptor OX1R. Orexin A human, rat, mouse TFA has a role in the regulation of feeding behavior. Orexin A human, rat, mouse TFA is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.

HY-P1051

β-amyloid (12-28) Amyloid β-Protein (12-28)	Amyloid-β	Neurological Disease
β-amyloid (12-28) is a peptide fragment of β-amyloid protein (β1-42). β1–42 a 42 amino acid protein , is the major component of senile plaque cores. β-amyloid (12-28) shows aggregation properties. β-amyloid (12-28) has the potential for Alzheimer’s disease research.

HY-106783A

Polymyxin B nonapeptide TFA	Bacterial	Infection
Polymyxin B nonapeptide TFA is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue. Polymyxin B nonapeptide TFA is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes.

HY-P1051A

β-amyloid (12-28) (TFA) Amyloid β-Protein (12-28) (TFA)	Amyloid-β	Neurological Disease
β-amyloid (12-28) TFA is a peptide fragment of β-amyloid protein (β1-42). β1–42 a 42 amino acid protein , is the major component of senile plaque cores. β-amyloid (12-28) shows aggregation properties. β-amyloid (12-28) has the potential for Alzheimer’s disease research.

HY-P0306

Fibronectin Adhesion-promoting Peptide Heparin Binding Peptide	Peptides	Cardiovascular Disease
Fibronectin Adhesion-promoting Peptide (Heparin Binding Peptide) is one of the heparin-binding amino acid sequences found in the carboxy-terminal heparin-binding domain of fibronectin. It promotes assembly of mesenchymal stem cell (MSC) spheroids into larger aggregates. Fibronectin Adhesion-promoting Peptide directly promotes the adhesion, spreading, and migration of endothelial cells by reacting with heparin binding domains of cells.

HY-P0306A

Fibronectin Adhesion-promoting Peptide TFA Heparin Binding Peptide TFA	Peptides	Cardiovascular Disease
Fibronectin Adhesion-promoting Peptide (Heparin Binding Peptide) is one of the heparin-binding amino acid sequences found in the carboxy-terminal heparin-binding domain of fibronectin. It promotes assembly of mesenchymal stem cell (MSC) spheroids into larger aggregates. Fibronectin Adhesion-promoting Peptide directly promotes the adhesion, spreading, and migration of endothelial cells by reacting with heparin binding domains of cells.

HY-P1829

Angiotensin I/II (1-6)	Peptides	Cardiovascular Disease
Angiotensin I/II 1-6 contains the amino acids 1-6 and is converted from Angiotensin I/II peptide. Angiotensin I is formed by the action of renin on angiotensinogen. Angiotensin II is produced from angiotensin I. Angiotensin II has been investigated for the treatment, basic science, and diagnostic of Hypertension, Renin Angiotensin System, and Idiopathic Membranous Nephropathy.

HY-P1746

Protein Kinase C (19-31) PKC (19-31)	PKC	Inflammation/Immunology
Protein Kinase C (19-31), a peptide inhibitor of protein kinase C (PKC), derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31) with a serine at position 25 replacing the wild-type alanine, is used as protein kinase C substrate peptide for testing the protein kinase C activity. Protein kinase C (PKC) is involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins.

HY-P1839

Angiotensin I/II (1-5)	Peptides	Cardiovascular Disease
Angiotensin I/II 1-5 is a peptide that contains the amino acids 1-5, which is converted from Angiotensin I/II. Angiotensin I is formed by the action of renin on angiotensinogen. Angiotensin II is produced from angiotensin I. Angiotensin II has been investigated for the treatment, basic science, and diagnostic of Hypertension, Renin Angiotensin System, and Idiopathic Membranous Nephropathy.

HY-P1746A

Protein Kinase C (19-31) (TFA) PKC (19-31) (TFA)	PKC	Inflammation/Immunology
Protein Kinase C (19-31) TFA, a peptide inhibitor of protein kinase C (PKC), derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31) with a serine at position 25 replacing the wild-type alanine, is used as protein kinase C substrate peptide for testing the protein kinase C activity. Protein kinase C (PKC) TFA is involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins.

HY-P1826

CLIP (86-100)	Peptides	Cancer Inflammation/Immunology
CLIP (86-100) is amino acids 86 to 100 fragment of class II-associated invariant chain peptide (CLIP). CLIP is a small self-peptide and cleavage product of the invariant chain that resides in the HLA-II antigen binding groove and is believed to play a critical role in the assembly and transport of MHC class II alphabetaIi complexes through its interaction with the class II peptide-binding site.

HY-P1854

β-Amyloid (1-9)	Amyloid-β	Neurological Disease
β-Amyloid (1-9), an N-terminal fragment of beta amyloid, consists of amino acid residues 1 to 9. β-Amyloid (1-9) contains a B cell epitope, but it does not include T cell epitopes. Omission of residues 1 to 9 from the full-length Alzheimer'sβ-Amyloid peptide 1 to 40 does not prevent the peptide from forming amyloid fibrils or eliminate fibril polymorphism .

HY-P1826A

CLIP (86-100) (TFA)	Peptides	Cancer Inflammation/Immunology
CLIP (86-100) TFA is amino acids 86 to 100 fragment of class II-associated invariant chain peptide (CLIP). CLIP is a small self-peptide and cleavage product of the invariant chain that resides in the HLA-II antigen binding groove and is believed to play a critical role in the assembly and transport of MHC class II alphabetaIi complexes through its interaction with the class II peptide-binding site.

HY-P1883

Bacterial Sortase Substrate III, Abz/DNP	Peptides	Infection
Bacterial Sortase Substrate III, Abz/DNP is an internally quenched fluorescent peptide substrate. Staphylococcus aureus transpeptidase sortase A (SrtA) reacts with its native substrate Bacterial Sortase Substrate III, Abz/DNP, cleaving it and catalyzing the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Cleavage of this substrate can be monitored at Ex/Em=320 nm/420 nm.

HY-P1922

γ-2-MSH (41-58), amide	Peptides	Endocrinology
γ-2-MSH (41-58), amide is derived from γ-2-MSH. γ-2-MSH is a twelve amino acid peptide that is derived from the N-terminal fragment of proopiomelanocortin (POMC) and contains the His-Phe-Arg-Trp motif common to all melanocortin endogenous agonist ligands.

HY-P1280

Margatoxin	Potassium Channel	Neurological Disease
Margatoxin, an alpha-KTx scorpion toxin, is a high affinity inhibitor of Kv1.3 (K_d=11.7 pM). Margatoxin inhibits the Kv1.2 (K_d=6.4 pM) and Kv1.1 (K_d=4.2 nM). Margatoxin, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research.

HY-P1883A

Bacterial Sortase Substrate III, Abz/DNP TFA	Peptides	Infection
Bacterial Sortase Substrate III, Abz/DNP TFA is an internally quenched fluorescent peptide substrate. Staphylococcus aureus transpeptidase sortase A (SrtA) reacts with its native substrate Bacterial Sortase Substrate III, Abz/DNP, cleaving it and catalyzing the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Cleavage of this substrate can be monitored at Ex/Em=320 nm/420 nm.

HY-P1136

Gap19	Gap Junction Protein	Cardiovascular Disease
Gap19, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 has protective effects against myocardial.

HY-P1136A

Gap19 TFA	Gap Junction Protein	Cardiovascular Disease
Gap19 TFA, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 TFA inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 TFA is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 TFA has protective effects against myocardial.

Cat. No.	Product Name	Target	Category

HY-30216

(R)-Leucic acid
D-α-Hydroxyisocaproic acid
Endogenous Metabolite Acids and Aldehydes

(R)-Leucic acid is an amino acid metabolite.

HY-113025A

L-hydroxylysine dihydrochloride (2S,5R)-5-Hydroxylysine dihydrochloride	Endogenous Metabolite	Acids and Aldehydes
L-hydroxylysine dihydrochloride ((2S,5R)-5-Hydroxylysine dihydrochloride), an amino acid, is exclusive to collagen protein, which is formed by posttranslational hydroxylation of some lysine residues.

HY-Y0123

DL-Tyrosine	Others	Acids and Aldehydes
DL-Tyrosine is an aromatic nonessential amino acid synthesized from the essential amino acid phenylalanine. DL-Tyrosine is a precursor for several important neurotransmitters (epinephrine, norepinephrine, dopamine).

HY-W017443

L-Asparagine monohydrate	Endogenous Metabolite	Acids and Aldehydes
L-Asparagine monohydrate ((-)-Asparagine monohydrate) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-100309

9-amino-CPT
9-Amino-20(S)-camptothecin
Topoisomerase Alkaloids

9-amino-CPT (9-amino-20(S)-camptothecin) is a topoisomerase I inhibitor with potent anticancer activity.
HY-59132

2-Amino-1-phenylethanol
Endogenous Metabolite Natural Products

2-Amino-1-phenylethanol is an analogue of noradrenaline.

HY-W002820

*2-Amino-5-phenylpyridine*	Endogenous Metabolite	Natural Products
2-Amino-5-phenylpyridine is a mutagenic heterocyclic aromatic amine that is formed by pyrolysis of phenylalanine in proteins. 2-Amino-5-phenylpyridine is in broiled sardines and is considered as potentially carcinogenic.

HY-W000450

5-Amino-4-oxopentanoic acid
Endogenous Metabolite Acids and Aldehydes

5-Amino-4-oxopentanoic acid is a non-protein amino acid that plays a rate-limiting role in heme biosynthesis.
HY-W010224

3-Amino-4-hydroxybenzoic acid
Endogenous Metabolite Acids and Aldehydes

3-Amino-4-hydroxybenzoic acid is an endogenous metabolite.
HY-W016734

2-Amino-5-ureidopentanoic acid
Endogenous Metabolite Acids and Aldehydes

2-Amino-5-ureidopentanoic acid is an endogenous metabolite.

HY-W012708

3-Amino-4-methylpentanoic acid	Endogenous Metabolite	Acids and Aldehydes
3-Amino-4-methylpentanoic acid is a beta amino acid and positional isomer of L-leucine which is naturally produced in humans via the metabolism of L-leucine by the enzyme leucine 2,3-aminomutase.

HY-W016480

4-Amino-L-phenylalanine
Endogenous Metabolite Natural Products

4-Amino-L-phenylalanine is an endogenous metabolite.

HY-N0325

DL-Methionine	Parasite	Natural Products
DL-Methionine is an essential amino acid containing sulfur with oxidative stress defense effects. DL-Methionine can be used for animal natural feed. DL-Methionine also kills *H. rostochiensis* on potato plants.

HY-W012974

3-Amino-2-methylpropanoic acid	Endogenous Metabolite	Acids and Aldehydes
3-Amino-2-methylpropanoic acid could induce browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors.

HY-129476

L-Canaline	Parasite Endogenous Metabolite	Natural Products
L-Canaline is a nonprotein amino acid stored in many leguminous plants. L-Canaline is a cytotoxic metabolite catalyzed by L-canavanine and its arginase. L-Canaline is a potent and irreversible inhibitor of ornithine aminotransferase. L-Canaline inhibits the growth of the malaria parasite *Plasmodium falciparum* with an IC₅₀ of 297 nM. L-Canaline has anticancer and antiproliferative effects.

HY-W008794

4-(2-Amino-1-hydroxyethyl)-2-methoxyphenol hydrochloride
Endogenous Metabolite Phenols

4-(2-Amino-1-hydroxyethyl)-2-methoxyphenol hydrochloride is an endogenous metabolite.
HY-W014504

2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid
Endogenous Metabolite Acids and Aldehydes

2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid is an endogenous metabolite.
HY-W016798

(S)-2-acetamido-4-amino-4-oxobutanoic acid
Endogenous Metabolite Acids and Aldehydes

(S)-2-acetamido-4-amino-4-oxobutanoic acid is an endogenous metabolite.
HY-128750

(Z)-4-Amino-4-oxobut-2-enoic acid
Endogenous Metabolite Acids and Aldehydes

(Z)-4-Amino-4-oxobut-2-enoic acid is an endogenous metabolite.

HY-N6030

(Rac)-Dencichin 2-Amino-3-(carboxyformamido)propanoic acid	Others	Natural Products
(Rac)-Dencichin (2-Amino-3-(carboxyformamido)propanoic acid) is the racemate of Dencichin. Dencichin is a non-protein amino acid originally extracted from Panax notoginseng, and can inhibit HIF-prolyl hydroxylase-2 (PHD-2) activity.

HY-B1122

L-Cycloserine (S)-Cycloserine; (S)-4-Amino-3-isoxazolidone	GABA Receptor HIV	Alkaloids
L-Cycloserine ((S)-4-Amino-3-isoxazolidone) irreversibly inhibits GABA pyridoxal 5′-phosphate-dependent aminitransferase in E.

HY-D0981

*7-Amino-4-(trifluoromethyl)coumarin* Coumarin 151; AFC	Others	Phenylpropanoids
7-Amino-4-(trifluoromethyl)coumarin (Coumarin 151) is a fluorescent marker for the sensitive detection of proteinases. The excitation and emission wavelengths are 400 and 490 nm, respectively.

HY-N0215

L-Phenylalanine (S)-2-Amino-3-phenylpropionic acid	Calcium Channel iGluR Endogenous Metabolite	Alkaloids Acids and Aldehydes
L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca⁺ channels antagonist with a K_i of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (K_B of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals.

HY-A0132

N-Acetyl-D-glucosamine N-Acetyl-2-Amino-2-deoxy-D-glucose	Endogenous Metabolite	Saccharides and Glycosides
N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of glucose.

HY-W008437

*(S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid* dihydrate**	Endogenous Metabolite	Acids and Aldehydes
(S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid dihydrate is an endogenous metabolite.

HY-41461

*5-Amino-3H-imidazole-4-Carboxamide* 5-Aminoimidazole-4-carboxamide; AICA	Endogenous Metabolite	Natural Products
5-Amino-3H-imidazole-4-Carboxamide (AICA) is an important precursor for the synthesis of purines in general and of the nucleobases adenine and guanine in particular.

HY-21088

*3-Amino-2-piperidinone* Cyclo-ornithine	Endogenous Metabolite	Natural Products
3-aminopiperidine-2-one is a metabolite from all living organisms. 3-aminopiperidine-2-one is a delta-lactam that is 2-piperidone substituted at position 3 by an amino group.

HY-122942

Moracin M	Phosphodiesterase (PDE) Endogenous Metabolite	Phenylpropanoids
Moracin M, a phenolic component in the skin of Morus alba L., is a potent phosphodiesterase-4 (PDE4) inhibitor with IC₅₀ values of 2.9, 4.5, >40, and >100 μM for PDE4D2, PDE4B2, PDE5A1, and PDE9A2, respectively. Moracin M has anti-inflammatory activity.

HY-N1860

3-O-Methylquercetin	Phosphodiesterase (PDE)	Flavonoids
3-O-Methylquercetin (3-MQ), a main constituent of Rhamnus nakaharai, inhibits total cAMP and cGMP-phosphodiesterase (PDE) of guinea pig trachealis. 3-O-Methylquercetin (3-MQ) exhibits IC₅₀ values of 31.9 μM， 86.9 μM， 18.6 μM and 1.6 μM for PDE1, PDE5, PDE2 and PDE4, respectively.

HY-W021425

*(2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride*	Endogenous Metabolite	Natural Products
(2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride is an endogenous metabolite.

HY-N7384

Vitamin B15 Pangamic Acid	Others	Acids and Aldehydes
Vitamin B15 (Pangamic Acid) is a natural, ubiquitously in plant seeds substance and can used be as an agent stimulating cellular respiration. Vitamin B15 contains D-gluconodimethyl amino acetic acid. Vitamin B15 is also a immune-correcting agent. Vitamin B15 can be used for wide range of diseases.

HY-N0014

Icariin Ieariline	Phosphodiesterase (PDE) PPAR Autophagy	Flavonoids Saccharides and Glycosides
Icariin is a flavonol glycoside. Icariin inhibits *PDE5* and *PDE4* activities with IC₅₀s of 432 nM and 73.50 μM, respectively. Icariin also is a PPARα activator.

HY-14520

Tetrahydrofolic acid L-5,6,7,8-Tetrahydrofolic acid; L-Tetrahydrofolic acid	Endogenous Metabolite	Natural Products
Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid.

HY-B0809

Theophylline 1,3-Dimethylxanthine; Theo-24	Adenosine Receptor Phosphodiesterase (PDE) Autophagy Endogenous Metabolite	Alkaloids
Theophylline is a nonselective phosphodiesterase (PDE) inhibitor, adenosine receptor blocker, and histone deacetylase (HDAC) activator.

HY-16558

Butein 2’,3,4,4’-tetrahydroxy Chalcone	EGFR Autophagy Apoptosis Phosphodiesterase (PDE)	Phenols
Butein, isolated from Dalbergia odorifera T. Chen, is a cAMP-specific *PDE* inhibitor with an IC₅₀ of 10.4 μM for *PDE4. Butein is a specific protein tyrosine kinase inhibitor with IC₅₀s of 16 and 65 μM for EGFR* and p60^c-src in HepG2 cells. Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a. Butein is a SIRT1 activator (STAC).

HY-W014502

D-Kynurenine	Aryl Hydrocarbon Receptor Endogenous Metabolite	Acids and Aldehydes
D-kynurenine, a metabolite of D-tryptophan, can serve as the bioprecursor of kynurenic acid (KYNA) and 3-hydroxykynurenine. D-Kynurenine is an agonist for G protein-coupled receptor, GPR109B. D-Kynurenine is a substrate in a fluorometric assay of D-amino acid oxidase. D-kynurenine promotes epithelial-to-mesenchymal transition via activating aryl hydrocarbon receptor (AHR).

HY-W018555

D-Cysteine	Endogenous Metabolite Bacterial	Acids and Aldehydes
D-Cysteine is the D-isomer of cysteine and a powerful inhibitor of *Escherichia coli* growth. D-cysteine is mediated by D-amino acid oxidase to produce H₂S and is a neuroprotectant against cerebellar ataxias. D-Cysteine could inhibit the growth and cariogenic virulence of dual-species biofilms formed by *S. mutans* and *S. sanguinis*.

HY-N0717

L-Valine
Endogenous Metabolite Alkaloids Acids and Aldehydes

L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid.
HY-N0771

L-Isoleucine
Endogenous Metabolite Alkaloids Acids and Aldehydes

L-isoleucine is a nonpolar hydrophobic amino acid. L-Isoleucine is an essential amino acid.

HY-W007970

H-Phe-Phe-OH	Endogenous Metabolite	Alkaloids Acids and Aldehydes
H-Phe-Phe-OH is a peptide made of two phenylalanine molecules; Phenylalanine is an essential amino acid and the precursor for the amino acid tyrosine.

HY-P0259

Xenin
Others Natural Products

Xenin is a 25-amino acid peptide initially isolated from human gastric mucosa. Xenin is a gut hormone that can reduce food intake.
HY-P0279

Systemin
Others Natural Products

Systemin, an 18-amino acid polypeptide, has been isolated from tomato leaves that is a powerful inducer of over 15 defensive genes.
HY-30215

(S)-Leucic acid
Endogenous Metabolite Natural Products

(S)-Leucic acid is an amino acid metabolite.
HY-P0324

Parasin I
Bacterial Natural Products

Parasin I is a 19-amino acid histone H2A-derived peptide isolated from the skin of the catfish, and shows antimicrobial activity.

HY-N0666B

*Aspartic acid* calcium** Calcium L-aspartate	Others	Alkaloids Acids and Aldehydes
Aspartic acid calcium (Calcium L-aspartate) is a chelate where calcium is attached to an amino acid naming L-Aspartic acid. L-Aspartic acid is an amino acid and serves as a building block for proteins in the body.

HY-113079

Argininic acid
Endogenous Metabolite Natural Products

Argininic acid is an α-amino acid that is used in the biosynthesis of proteins.

HY-W018678

8-Aminooctanoic acid	Others	Acids and Aldehydes
8-Aminooctanoic acid is an omega-amino fatty acid that is octanoic acid which carries an amino group at position 8. 8-aminooctanoic acid has a role as a human metabolite.

HY-P0324A

Parasin I TFA
Bacterial Natural Products

Parasin I (TFA) is a 19-amino acid histone H2A-derived peptide isolated from the skin of the catfish, and shows antimicrobial activity.
HY-B0030

D-Cycloserine
Bacterial Antibiotic Alkaloids Natural Products

D-Cycloserine is an analog of the amino acid D-alanine.
HY-B0137A

Prilocaine hydrochloride
Na+/K+ ATPase Natural Products

Prilocaine hydrochloride is an amino amide type compound that used for anesthesia.
HY-B0137

Prilocaine
Na+/K+ ATPase Natural Products

Prilocaine is an amino amide type compound that used for anesthesia.
HY-113426

Nepsilon-Acetyl-L-lysine
Endogenous Metabolite Acids and Aldehydes

Nepsilon-Acetyl-L-lysine is a derivative of the amino acid lysine.
HY-B2236

DL-Lysine
(±)-2,6-DiAminocaproic acid
Others Acids and Aldehydes

DL-Lysine (Lysine) is an α-amino acid that is used in the biosynthesis of proteins.
HY-W010040

4-Hydroxyphenylpyruvic acid
Endogenous Metabolite Natural Products

4-Hydroxyphenylpyruvic acid is an intermediate in the metabolism of the amino acid phenylalanine.
HY-113227

Oxoadipic acid
Endogenous Metabolite Natural Products

Oxoadipic acid is a key metabolite of the essential amino acids tryptophan and lysine.
HY-W050026

Phenylacetylglutamine
NSC 203800; Phenylacetyl-L-glutamine
Endogenous Metabolite Acids and Aldehydes

Phenylacetylglutamine is a colonic microbial metabolite from amino acid fermentation.
HY-N2309

Kainic acid
Others Alkaloids Acids and Aldehydes

Kainic acid is a potent agonist at excitatory amino acid receptor subtypes in the CNS.
HY-W009749

L-Cystathionine
Endogenous Metabolite Natural Products

L-Cystathionine is a key nonprotein amino acid related to metabolic conditions.

HY-Y1139

Pimelic acid Heptanedioic acid; 1,5-Pentanedicarboxylic acid; 1,7-Heptanedioic acid	Endogenous Metabolite	Acids and Aldehydes
Pimelic acid is the organic compound and its derivatives are involved in the biosynthesis of the amino acid called lysine.

HY-Y0127

D(-)-2-Aminobutyric acid
Endogenous Metabolite Acids and Aldehydes

D(-)-2-Aminobutyric acid is a substrate of D-amino acid oxidase.

HY-Y0511

N-Methylsarcosine Dimethylglycine; DMG; N,N-Dimethylglycine	Endogenous Metabolite	Acids and Aldehydes
N-Methylsarcosine is an amino acid building block for protein, found in a small amount in the body.

HY-100496

Nucleocidin 4'-Fluoro-5'-O-sulfamoyladenosine; NSC 521007	Bacterial	Natural Products
Nucleocidin is an antitrypanosomal antibiotic, inhibiting the transfer of labeled amino acid from S-RNA to protein.

HY-N6256

Ilexsaponin B2	Phosphodiesterase (PDE)	Terpenoids and Glycosides
Ilexsaponin B2 is a saponin isolated from the root of Ilex pubescens Hook. et Arn. Ilexsaponin B2 is a potent phosphodiesterase 5 (PDE5) and PDEI inhibitor with IC₅₀ values of 48.8 μM and 477.5 μM, respectively.

HY-Y0337

L-Cysteine
Endogenous Metabolite Ferroptosis Acids and Aldehydes

L-Cysteine is a thiol-containing non-essential amino acid that is oxidized to form cystine.
HY-N0666

L-Aspartic acid
Endogenous Metabolite Alkaloids Acids and Aldehydes

L-Aspartic acid is is an amino acid, shown to be a suitable prodrug for colon-specific drug deliverly.

HY-N0832

L-Histidine	Mitochondrial Metabolism Endogenous Metabolite	Alkaloids Acids and Aldehydes
L-Histidine is an essential amino acid for infants. L-Histidine is an inhibitor of mitochondrial glutamine transport.

HY-Y0252

L-Proline
Endogenous Metabolite Acids and Aldehydes

L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins.
HY-113380

(S)-b-aminoisobutyric acid
Endogenous Metabolite Acids and Aldehydes

(S)-b-aminoisobutyric acid is a non-protein amino acid originating from the catabolism of thymine and valine.
HY-113232

3-Methylcrotonylglycine
Endogenous Metabolite Natural Products

3-Methylcrotonylglycine is an acyl glycine, a normal amino acid metabolite found in urine.

HY-P1841

Glucagon-Like Peptide (GLP) II, human	Endogenous Metabolite	Natural Products
Glucagon-Like Peptide (GLP) II, human is a 33-amino acid peptide derived from the C-terminal of proglucagon and mainly produced by the intestinal L cells. Glucagon-Like Peptide (GLP) II, human stimulates intestinal mucosal growth and decreases apoptosis of enterocytes .

HY-N0454

DL-Arginine
Others Alkaloids Acids and Aldehydes

DL-Arginine is used in physicochemical analysis of amino acid complexation dynamics and crystal structure formations.

HY-B1000

Selenomethionine Seleno-DL-methionine; DL-Selenomethionine	Autophagy Endogenous Metabolite	Acids and Aldehydes
Selenomethionine is a naturally occurring amino acid containing selenium, is a common natural food source of selenium.

HY-101409

O-Acetylserine O-Acetyl-L-serine	Endogenous Metabolite	Alkaloids Acids and Aldehydes
O-Acetylserine (O-Acetyl-L-serine) is an intermediate in the biosynthesis of the amino acid cysteine in bacteria and plants.

HY-113080

N-Acetylornithine
Endogenous Metabolite Alkaloids Acids and Aldehydes

N-Acetylornithine is an intermediate in the enzymatic biosynthesis of the amino acid L-arginine from L-glutamate.
HY-N0473

L-Tyrosine
Endogenous Metabolite Natural Products

L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-101404

DL-Homocysteine thiolactone hydrochloride	Endogenous Metabolite	Natural Products
DL-Homocysteine thiolactone hydrochloride is a cyclic amino acid derivative that exhibits root-growth inhibitory activity.

HY-104026

L-Kynurenine	Aryl Hydrocarbon Receptor Endogenous Metabolite	Alkaloids Acids and Aldehydes
L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist.

HY-N0130

Shikimic acid
Endogenous Metabolite Acids and Aldehydes

Shikimic acid is a key metabolic intermediate of the aromatic amino acid biosynthesis pathway, found in microbes and plants.

HY-W002292

L-Homoserine	Endogenous Metabolite	Alkaloids Acids and Aldehydes
L-Homoserine is a non - protein amino acid, which is an important biosynthetic intermediate of threonine, methionine and lysine.

HY-N0326

L-Methionine	Endogenous Metabolite	Alkaloids Acids and Aldehydes
L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.

HY-114158

Pronase E
Pronase
Others Natural Products

Pronase E is a mixture of proteolytic enzymes that is obtained from Streptomyces griseus and could digest protein into individual amino acids.
HY-N0658A

DL-Threonine
Others Alkaloids Acids and Aldehydes

DL-Threonine, an essential amino acid, has the potential to treat hypostatic leg ulceration.

HY-N0390

L-Glutamine L-Glutamic acid 5-amide	mGluR Endogenous Metabolite Ferroptosis	Alkaloids Acids and Aldehydes
L-Glutamine is a non-essential amino acid present abundantly throughout the body and is involved in gastrointestinal disorders.

HY-N0394

L-Cystine	Endogenous Metabolite Ferroptosis	Alkaloids Acids and Aldehydes
L-Cystine is an amino acid and intracellular thiol, which plays a critical role in the regulation of cellular processes.

HY-N0230

β-Alanine 2-Carboxyethylamine; 3-Aminopropanoic acid	Endogenous Metabolite	Alkaloids Acids and Aldehydes
β-Alanine is a non-essential amino acid that is shown to be metabolized into carnosine, which functions as an intracellular buffer.

HY-113379

2,3-Diaminopropionic acid
Endogenous Metabolite Acids and Aldehydes

2, 3-Diaminopropionic acid is a metabolite of b-oxalyl-L-a, b-diaminopropionic acid a neurotoxic amino acid (ODAP).
HY-W010388

Creatine
Endogenous Metabolite Acids and Aldehydes

Creatine, an endogenous amino acid derivative, plays an important role in cellular energy, especially in muscle and brain.

HY-14602

Tramiprosate Homotaurine; 3-Amino-1-propanesulfonic acid	Amyloid-β	Acids and Aldehydes
Tramiprosate is a small, orally-administered compound that binds to soluble Aβ and reduces amyloid aggregation and subsequent deposition target: Aβ In vitro: Tramiprosate provides neuroprotection against Aβ-induced neurotoxicity in neuronal and mouse organotypic hippocampal cultures, and reverses Aβ-induced long-term potentiation (LTP) inhibition in rat hippocampus, in part, through activation of β-aminobutyric acid A (GABA-A) receptors.

HY-N0623

L-Tryptophan Tryptophan; Tryptophane	Endogenous Metabolite	Alkaloids Acids and Aldehydes
L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3.

HY-W017018

L-Ornithine hydrochloride	Endogenous Metabolite	Acids and Aldehydes
L-Ornithine hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen.

HY-N0667

L-Asparagine (-)-Asparagine; Asn; Asparamide	Endogenous Metabolite	Alkaloids Acids and Aldehydes
L-Asparagine ((-)-Asparagine) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-N0666C

L-Aspartic aicd sodium Sodium L-aspartate	Endogenous Metabolite	Alkaloids Acids and Aldehydes
L-Aspartic aicd sodium is is an amino acid, shown to be a suitable prodrug for colon-specific drug deliverly.

HY-107383

Tetrahydrobiopterin Sapropterin	NO Synthase Endogenous Metabolite	Saccharides and Glycosides
Tetrahydrobiopterin is a cofactor of the *aromatic amino* acid hydroxylases enzymes and also acts as an essential cofactor for all nitric oxide synthase** (NOS) isoforms.

HY-N0486

L-Leucine
mTOR Alkaloids Acids and Aldehydes

L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.

HY-100803

Hypotaurine 2-Aminoethanesulfinic acid	Endogenous Metabolite	Natural Products
Hypotaurine (2-aminoethanesulfinic acid), an intermediate in taurine biosynthesis from cysteine in astrocytes, is an endogenous inhibitory amino acid of the glycine receptor.

HY-N0658

L-Threonine
Endogenous Metabolite Alkaloids Acids and Aldehydes

L-Threonine is a natural amino acid, can be produced by microbial fermentation, and is used in food, medicine, or feed.

HY-P0173A

Chlorotoxin	Chloride Channel	Natural Products
Chlorotoxin is a 36 amino-acid peptide from the venom of the Israeli scorpion Leiurus quinquestriatus with anticancer activity. Chlorotoxin is a chloride channel blocker.

HY-W017462

Creatine monohydrate	Endogenous Metabolite	Acids and Aldehydes
Creatine monohydrate, an endogenous amino acid derivative, plays an important role in cellular energy, especially in muscle and brain.

HY-W016443

L-m-Tyrosine
Others Acids and Aldehydes

L-m-Tyrosine is an unnatural amino acid, that has potential in the research of Parkinsons disease, Alzheimers disease, and arthritis.

HY-W013494

L-Carnosine	Endogenous Metabolite	Alkaloids Acids and Aldehydes
L-Carnosine is a dipeptide of the amino acids beta-alanine and histidine and has the potential to suppress many of the biochemical changes that accompany aging.

HY-W016823

Tyramine hydrochloride	Endogenous Metabolite	Phenols
Tyramine hydrochloride is an amino acid that helps regulate blood pressure. Tyramine hydrochloride occurs naturally in the body, and it's found in certain foods.

HY-W007606

Tyramine
Endogenous Metabolite Phenols

Tyramine is an amino acid that helps regulate blood pressure. Tyramine occurs naturally in the body, and it's found in certain foods.

HY-N0384

Homovanillic acid Vanilacetic acid	Endogenous Metabolite	Acids and Aldehydes
Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.

HY-N0650

L-Serine (-)-Serine; (S)-Serine	Endogenous Metabolite	Alkaloids Acids and Aldehydes
L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-B1295

*Citric acid* trilithium salt tetrahydrate** Lithium citrate tribasic tetrahydrate; Trilithium citrate tetrahydrate	Bacterial	Acids and Aldehydes
Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) is a pharmaceutical and construction material, used in HPLC gradient elution for quantitative amino acid analysis.

HY-N0391

L-Citrulline	Endogenous Metabolite	Alkaloids Acids and Aldehydes
L-Citrulline is an amino acid derived from ornithine in the catabolism of proline or glutamine and glutamate, or from l-arginine via arginine-citrulline pathway.

HY-W012382

N-Acetyl-L-tyrosine	Endogenous Metabolite	Alkaloids Phenols Acids and Aldehydes
N-Acetyl-L-tyrosine originates from tyrosine through an AA acetylase, is associated with aromatic L-amino acid decarboxylase deficiency and tyrosinemia I.

HY-I1060

L-Alloisoleucine (3R)-LS-Isoleucine; L-Allo-isoleucine	Endogenous Metabolite	Natural Products
L-Alloisoleucine is a branched chain amino acid and is a stereo-isomer of L-isoleucine. L-Alloisoleucine is a common constituent of human plasma (albeit at low levels).

HY-N0229

L-Alanine L-2-Aminopropionic acid	Endogenous Metabolite	Alkaloids Acids and Aldehydes
L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.

HY-N1477

Dencichine Dencichin; ODAP	HIF/HIF Prolyl-Hydroxylase	Natural Products
Dencichin is a non-protein amino acid originally extracted from Panax notoginseng, and can inhibit HIF-prolyl hydroxylase-2 (PHD-2) activity.

HY-N3894

Ferulamide
nAChR Alkaloids

Ferulamide is a Ferulic acid derivative isolated from Portulaca oleracea L. with anticholinesterase activities.
HY-Y1362

Ethyl pyruvate
Others Natural Products

Ethyl pyruvate is a simple derivative of the endogenous metabolite, pyruvic acid. Ethyl pyruvate is an anti-inflammatory agent.

HY-W015410

Disodium succinate	Others	Natural Products
Disodium succinate is the disodium salt of Succinic acid. Succinic acid is an intermediate product of the tricarboxylic acid cycle, as well as one of fermentation products of anaerobic metabolism.

HY-N3010

Salviaflaside
Others Phenylpropanoids

Salviaflaside is a main bioactive component of Spica Prunellae.

HY-76547

p-Toluic acid 4-Methylbenzoic acid	Endogenous Metabolite	Acids and Aldehydes
p-Toluic acid (4-Methylbenzoic acid) is a substituted benzoic acid and can be used as an intermediate for the synthesis of para-aminomethylbenzoic acid (PAMBA), p-tolunitrile, etc.

HY-W011819

Tetradecanedioic acid	Endogenous Metabolite	Acids and Aldehydes
Tetradecanedioic acid is an endogenous metabolite and belongs to the class of organic compounds known as long-chain fatty acids. Tetradecanedioic acid can act as a candidate biomarker for organic anion-transporting polypeptide mediated drug-drug interactions .

HY-W012499

N-Acetyl-L-methionine N-Acetylmethionine	Endogenous Metabolite	Natural Products
N-Acetyl-L-methionine, a human metabolite, is nutritionally and metabolically equivalent to L-methionine. L-methionine is an indispensable amino acid required for normal growth and development.

HY-D0885B

Phosphocreatine disodium Disodium creatine phosphate	Endogenous Metabolite	Alkaloids Acids and Aldehydes
Phosphocreatine disodium, one of organic compounds known as alpha amino acids and derivatives, is a substrate for the determination of creatine kinase and used to regenerate ATP during skeletal muscle contraction.

HY-N0470

L-Lysine hydrochloride	Virus Protease	Alkaloids Acids and Aldehydes
L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.

HY-13295

Vinpocetine Ethyl apovincaminate	Sodium Channel IKK Phosphodiesterase (PDE)	Alkaloids
Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na⁺ channels. The IC₅₀ value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders.

HY-N2284

Sophoflavescenol	AChE Beta-secretase Phosphodiesterase (PDE)	Flavonoids
Sophoflavescenol is a prenylated flavonol, which shows great inhibitory activity with IC₅₀ of 0.013 μM against Phosphodiesterase 5 (PDE5), and also inhibits RLAR, HRAR, AGE, BACE1, AChE and BChE with IC₅₀s of 0.30 µM, 0.17 µM, 17.89 µg/mL, 10.98 µM, 8.37 µM and 8.21 µM, respectively.

HY-113063

3-Methyl-2-oxovaleric acid	Endogenous Metabolite	Acids and Aldehydes
3-Methyl-2-oxovaleric acid is a neurotoxin, an acidogen, and a metabotoxin, and also an abnormal metabolite that arises from the incomplete breakdown of branched-chain amino acids.

HY-W015240

N-Acetyl-L-glutamic acid	Endogenous Metabolite	Natural Products
N-Acetyl-L-glutamic acid, a N-acyl-L-amino acid, is a component of animal cell culturing media. N-Acetyl-L-glutamic acid is a metabolite of Saccharomyces cerevisiae and human.

HY-N0122

5-Hydroxytryptophan 5-HTP; DL-5-Hydroxytryptophan	Endogenous Metabolite	Alkaloids Acids and Aldehydes
5-Hydroxytryptophan, a tryptophan metabolite, is a direct 5-hydroxytryptamine (5-HT) precursor and an L-aromatic amino acid decarboxylase substrate. .

HY-N6848

Acetylseneciphylline N-oxide	Others	Alkaloids
Acetylseneciphylline N-oxide is a pyrrolizine alkaloid that is seneciphylline in which the hydroxy hydrogen is replaced by an acetyl group and the tertiary amino function is oxidised to the corresponding N-oxide.

HY-P0288

[Leu5]-Enkephalin Leu-enkephalin; Leucine enkephalin; Leucyl-enkephalin	Opioid Receptor Endogenous Metabolite	Acids and Aldehydes
[Leu5]-Enkephalin is a pentapeptides with morphine like properties. [Leu5]-Enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.

HY-P0223

FLAG peptide	Others	Acids and Aldehydes
FLAG peptide is an eight amino acids peptide (Asp-Tyr-Lys-Asp-Asp-Asp-Asp-Lys) with an enterokinase-cleavage site; designed for antibody-mediated identification and purification of recombinant proteins.

HY-D0885

Phosphocreatine Creatine phosphate; Creatinephosphoric acid	Endogenous Metabolite	Natural Products
Phosphocreatine, primarily found in the skeletal muscles of vertebrates and one of organic compounds known as alpha amino acids and derivatives, is a substrate for the determination of creatine kinase and used to regenerate ATP during skeletal muscle contraction..

HY-P0292

GnRH-I	Others	Natural Products
GnRH-I is a small 10 amino acid long peptide (decapeptide) from the hypothalamus, acts at the hypophysis to cause an increase in release of biologically active Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH) in the blood.

HY-P0285

Rabies Virus Glycoprotein	Others	Natural Products
Rabies Virus Glycoprotein is a 29-amino-acid cell penetrating peptide derived from a rabies virus glycoprotein that can cross the blood-brain barrier (BBB) and enter brain cells.

HY-N0469

L-Lysine	Endogenous Metabolite Virus Protease	Alkaloids Acids and Aldehydes
L-lysine is an essential amino acid with important roles in connective tissues and carnitine synthesis, energy production, growth in children, and maintenance of immune functions.

HY-43470

3α,12β-Dihydroxycholanoic acid
Endogenous Metabolite Acids and Aldehydes

3α,12β-Dihydroxycholanoic acid is a bile acid that can be isolated from urine specimens of healthy humans.
HY-125686

Beesioside Q
Others Terpenoids and Glycosides

Beesioside Q is a oleanolic acid triterpene saponin isolated from the rhizome of Beesia calthaefolia (Maxim.) Ulbr.

HY-107830

Methyl cholate	Others	Steroids
Methyl Cholate is methyl ester form of Cholic acid. Cholic acid is one of the major bile acids produced by the liver, where it is synthesized from cholesterol.

HY-D0885C

Phosphocreatine dipotassium Creatine phosphate (dipotassium); Creatinephosphoric acid (dipotassium)	Endogenous Metabolite	Natural Products
Phosphocreatine dipotassium, primarily found in the skeletal muscles of vertebrates and one of organic compounds known as alpha amino acids and derivatives, is a substrate for the determination of creatine kinase and used to regenerate ATP during skeletal muscle contraction.

HY-B0762

Acetyl-L-carnitine hydrochloride O-Acetyl-L-carnitine (hydrochloride)	Endogenous Metabolite	Natural Products
Acetyl-L-carnitine hydrochloride is a blood-brain permeable acetyl ester of the amino acid L-carnitine found in the body. Acetyl-L-carnitine hydrochloride is often used as a dietary supplement, and exibits anti-stress-related psychiatric disorders.

HY-D0885A

Phosphocreatine disodium tetrahydrate Creatine phosphate (disodium tetrahydrate); Creatinephosphoric acid (disodium tetrahydrate)	Endogenous Metabolite	Natural Products
Phosphocreatine disodium tetrahydrate, primarily found in the skeletal muscles of vertebrates and one of organic compounds known as alpha amino acids and derivatives, is a substrate for the determination of creatine kinase and used to regenerate ATP during skeletal muscle contraction.

HY-N3945

Glaucine O,O-Dimethylisoboldine; S-(+)-Glaucine; NSC 34396	Phosphodiesterase (PDE) Calcium Channel Adrenergic Receptor Dopamine Receptor Influenza Virus	Alkaloids
Glaucine (O,O-Dimethylisoboldine) is an alkaloid isolated from Glaucium flavum Crantz with antitussive, bronchodilation and anti-inflammatory properties. Glaucine is a selective and orally active phosphodiesterase 4 (PDE4) inhibitor with K_is of 3.4 µM in human bronchus and polymorphonuclear leukocytes. Glaucine is also a non-selective α-adrenoceptor antagonist, a Ca²⁺ entry blocker, and a weak dopamine D1 and D2 receptor antagonist. Glaucine has antioxidative and antiviral activities.

HY-Y0337A

L-Cysteine hydrochloride	Endogenous Metabolite	Acids and Aldehydes
L-Cysteine hydrochloride is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride suppresses ghrelin and reduces appetite in rodents and humans.

HY-W008097

3,3-Dimethylglutaric acid	Endogenous Metabolite	Acids and Aldehydes
3,3-Dimethylglutaric acid, a member of methyl-branched fatty acids, is a endogenous metabolite occasionally found in human urine.

HY-130803

5-Methyl-5,6-dihydrouridine	Others	Natural Products
5-Methyl-5,6-dihydrouridine is a minor constituent in the chromosomal RNA of the rat ascites tumor. 5-Methyl-5,6-dihydrouridine can be used for nucleic acid modification.

HY-113437A

1,2-Dipalmitoyl-sn-glycerol 3-phosphate sodium	Endogenous Metabolite	Natural Products
1,2-Dipalmitoyl-sn-glycerol 3-phosphate sodium (compound 3-F7) is a phosphatidic acid and a human endogenous metabolite

HY-P0253

Xenopsin
Others Natural Products

Xenopsin, a neurotensin-like octapeptide from Xenopus laevis skin. Xenopsin is an inhibitor of Tetragastrin stimulated gastric acid secretion.

HY-W009082

Methyl behenate Methyl docosanoate	Others	Natural Products
Methyl behenate (Methyl docosanoate) is a naturally fatty acid methyl ester isolated from the plant of Aspidopterys obcordata Lemsl.

HY-W005178

Octadecanedioic acid	Endogenous Metabolite	Acids and Aldehydes
Octadecanedioic acid, an endogenous metabolite, is a long-chain dicarboxylic acid that has been found in serum free fatty acid profile in Reye syndrome.

HY-N7354

Quininic acid
Others Acids and Aldehydes

Quininic acid, purified from Eucalyptus globulus, cinchona bark, and other plant products, is the most abundant organic acid.

HY-A0143

Dihomo-γ-linolenic acid all-cis-8,11,14-Eicosatrienoic acid	Endogenous Metabolite	Acids and Aldehydes
Dihomo-γ-linolenic acid (all-cis-8,11,14-Eicosatrienoic acid) is a 20-carbon ω-6 fatty acid, with anti-inflammatory and anti-proliferative activities. Dihomo-γ-linolenic acid attenuates atherosclerosis in the apolipoprotein E deficient mouse model system.

HY-N6858

4-Hydroxyisoleucine 4-Hydroxy-L-isoleucine	Others	Natural Products
4-Hydroxyisoleucine (4-Hydroxy-L-isoleucine) is an amino acid which can be extracted and purified from fenugreek seeds. 4-Hydroxyisoleucine (4-Hydroxy-L-isoleucine) displays an insulinotropic activity of great interest.

HY-B0236

6-Aminocaproic acid EACA; Epsilon-Amino-n-caproic Acid; 6-Aminohexanoic acid	Others	Alkaloids Acids and Aldehydes
6-Aminocaproic acid is an antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.

HY-75308

Azetidine-2-carboxylic acid	Others	Acids and Aldehydes
Azetidine-2-carboxylic acid is a non proteinogenic amino acid homologue of proline. Found in common beets. Azetidine-2-carboxylic acid can be misincorporated into proteins in place of proline in many species, including humans. Toxic and teratogenic agent.

HY-P1904

Phe-Met-Arg-Phe Like Peptide, Snail Helix aspersa	Others	Natural Products
Phe-Met-Arg-Phe Like Peptide, Snail Helix aspersa is a FMRF-like peptide from visceral and somatic muscles of the snail Helix aspersa. FMRF (Phe-Met-Arg-Phe) is a neuropeptide peptide consisting of 4 amino acid residues.

HY-19528

SAH SAH (S-Adenosylhomocysteine)	Endogenous Metabolite	Alkaloids Acids and Aldehydes
SAH is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC₅₀ of 0.9 µM.

HY-P1293

Conantokin G	iGluR	Acids and Aldehydes
Conantokin G, a 17-amino-acid peptide, is a potent, selective and competitive antagonist of N-methyl-D-aspartate (NMDA) receptors. Conantokin G inhibits NMDA-evoked currents in murine cortical neurons with an IC₅₀ of 480 nM. Conantokin G has neuroprotective properties.

HY-113130

Eicosadienoic acid
Endogenous Metabolite Natural Products

Eicosadienoic acid is a rare, naturally occurring n-6 polyunsaturated fatty acid found mainly in animal tissues.
HY-124422

Pentacosanoic acid
Endogenous Metabolite Acids and Aldehydes

Pentacosanoic acid is a 25-carbon long-chain saturated fatty acid. Pentacosanoic is a conjugate acid of a pentacosanoate.

HY-W018512

7-Ketolithocholic acid 3α-Hydroxy-7-oxo-5β-cholanic acid	Endogenous Metabolite	Acids and Aldehydes
7-Ketolithocholic acid (3α-Hydroxy-7-oxo-5β-cholanic acid), a bile acid, can be absorbed and suppresses endogenous bile acid production and biliary cholesterol secretion.

HY-N7031

(±)-Vasicine (±)-Peganine	Proton Pump	Natural Products
(±)-Vasicine is the racemate of Vasicine. Vasicine (Peganine), isolated from Peganum harmala seeds, significantly inhibits H⁺-K⁺-ATPase activity in vitro with an IC₅₀ of 73.47 μg/mL. Anti-ulcer activity. Vasicine shows significant anti-secretory, antioxidant and cytoprotective effect.

HY-W010832

Uridine-5'-diphosphate disodium salt	P2Y Receptor DNA/RNA Synthesis Endogenous Metabolite	Natural Products
Uridine-5'-diphosphate disodium salt is a potent, selective P2Y₆ receptor native agonist (EC₅₀=300 nM; pEC₅₀=6.52) and a potent P2Y₁₄ antagonist (pEC₅₀=7.28). Uridine-5'-diphosphate disodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis.

HY-W015495

L-Dihydroorotic acid
Endogenous Metabolite Acids and Aldehydes

L-Dihydroorotic acid can reversibly hydrolyze to yield the acyclic L-ureidosuccinic acid by dihydrowhey enzyme.

HY-W011688

Methyl palmitoleate (Z)-Methyl hexadec-9-enoate; Methyl cis-9-Hexadecenoate	Others	Natural Products
Methyl palmitoleate ((Z)-Methyl hexadec-9-enoate), a fatty acid methyl ester, is an analogue of Palmitoleate with cytoprotective and growth-promoting properties.

HY-W010820

Uridine 5'-diphosphate sodium salt	P2Y Receptor DNA/RNA Synthesis Endogenous Metabolite	Natural Products
Uridine 5'-diphosphate sodium salt is a potent, selective P2Y₆ receptor native agonist (EC₅₀=300 nM; pEC₅₀=6.52) and a potent P2Y₁₄ antagonist (pEC₅₀=7.28). Uridine 5'-diphosphate sodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis.

HY-Y0444

D-Tyrosine	Tyrosinase	Acids and Aldehydes
D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth.

HY-N4120

Valechlorine	Autophagy	Natural Products
Valechlorine, a autophagy enhancer, breaks down lipid droplets. Valechlorine reduces oleic acid (OA)-induced lipid accumulation in an Atg5-dependent manner.

HY-W001959

D-Allothreonine	Endogenous Metabolite	Natural Products
D-Allothreonine is the D type stereoisomer of Allothreonine. D-Allothreonine is a peptido-lipid derived from bacteria. D-Allothreonine, amide-linked to the D-galacturonic acid, is also a constituent in the polysaccharide.

HY-N6998

Paederosidic acid	Apoptosis	Terpenoids and Glycosides
Paederosidic acid is isolated from P. scandens with anticancer and anti‐inflammation activities. Paederosidic acid inhibits lung caner cells via inducing mitochondria-mediated apoptosis.

HY-N7132

Menthyl acetate L-Menthyl acetate; (-)-Menthyl acetate	Others	Natural Products
Menthyl acetate (L-Menthyl acetate) is a derivative of L-menthol. Menthyl acetate is effective to enhance 5-aminolevulinic acid (ALA) skin permeation.

HY-16007

(-)-Hydroxycitric acid Garcinia acid	ATP Citrate Lyase	Acids and Aldehydes
(-)-Hydroxycitric acid (Garcinia acid) is the principal acid of fruit rinds of Garcinia cambogia. (-)-Hydroxycitric acid is a potent and competitive inhibitor of ATP citrate lyase. (-)-Hydroxycitric ac

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