Angiogenin

By Targets:	Antibiotic (1) Bacterial (3) Phospholipase (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (4) Infection (3) Neurological Disease (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0470

Neomycin sulfate 20+ Cited Publications	Bacterial Antibiotic Phospholipase	Infection
Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis .

HY-N7449

Neamine	Bacterial	Infection Cardiovascular Disease Neurological Disease Cancer
Neamine, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine is an anti-angiogenesis agent targeting *angiogenin*. Neamine has potent antibacterial, antitumor and neuroprotective activities .

HY-115349

Neamine tetrahydrochloride	Bacterial	Infection Neurological Disease Cancer
Neamine tetrahydrochloride, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine tetrahydrochloride is an anti-angiogenesis agent targeting *angiogenin*. Neamine tetrahydrochloride has potent antibacterial, antitumor and neuroprotective activities .

Cat. No.	Product Name

HY-L088

Angiogenesis-Related Compound Library	1960 compounds
Angiogenesis is the physiological process through which new blood vessels are formed from pre-existing vessels. It occurs in various physiological processes e.g. embryonic development, menstrual cycle, exercise and wound healing etc. Angiogenesis is regulated by both endogenous activators and inhibitors. Some key activators of angiogenesis include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), angiogenin, TGF-β, etc. whereas angiogenesis inhibitors are angiostatin, endostatin, interferon, platelet factor 4, etc. The loss of balance between these opposing signals leads to life threatening diseases like cancer, cardiovascular and ischemic diseases etc. which are thus controlled by exogenous angiogenesis activators (for cardiovascular/ischemic disorders) and inhibitors (for cancer). MCE offers a unique collection of 1960 compounds with validated angiogenesis targets modulating properties. MCE angiogenesis-related compound library is an effective tool for angiogenesis research and discovery of angiogenesis-related drugs.

1960 compounds

Angiogenesis is the physiological process through which new blood vessels are formed from pre-existing vessels. It occurs in various physiological processes e.g. embryonic development, menstrual cycle, exercise and wound healing etc. Angiogenesis is regulated by both endogenous activators and inhibitors. Some key activators of angiogenesis include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), angiogenin, TGF-β, etc. whereas angiogenesis inhibitors are angiostatin, endostatin, interferon, platelet factor 4, etc. The loss of balance between these opposing signals leads to life threatening diseases like cancer, cardiovascular and ischemic diseases etc. which are thus controlled by exogenous angiogenesis activators (for cardiovascular/ischemic disorders) and inhibitors (for cancer).

MCE offers a unique collection of 1960 compounds with validated angiogenesis targets modulating properties. MCE angiogenesis-related compound library is an effective tool for angiogenesis research and discovery of angiogenesis-related drugs.

Cat. No.	Product Name	Target	Research Area

HY-P1516A

Angiogenin (108-122) (TFA)

Peptides Cardiovascular Disease Cancer

Angiogenin (108-122) TFA is an angiogenin peptide.

Angiogenin (108-122) (TFA)	Peptides	Cardiovascular Disease Cancer
Angiogenin (108-122) TFA is an angiogenin peptide.

HY-W140249

Angiogenin Fragment (108-123)	Peptides	Cardiovascular Disease
Angiogenin Fragment (108-123) is a C-terminal segment 108-123 of Angiogenin that inhibits the enzymatic and biological activities of Angiogenin .

HY-P1516

Angiogenin (108-122)

Peptides Cardiovascular Disease Cancer

Angiogenin (108-122) is an angiogenin peptide.

Angiogenin (108-122)	Peptides	Cardiovascular Disease Cancer
Angiogenin (108-122) is an angiogenin peptide.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0470

Neomycin sulfate 20+ Cited Publications	Structural Classification Classification of Application Fields Source classification Antibacterial Disease Research Other Antibiotics Infection Microorganisms Antibiotics Animal Husbandry Mammalian Cell Culture Anticancer Disease Research Fields	Bacterial Antibiotic Phospholipase
Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis .

HY-N7449

Neamine	Cardiovascular Disease Infection Classification of Application Fields Disease Research Fields	Bacterial
Neamine, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine is an anti-angiogenesis agent targeting *angiogenin*. Neamine has potent antibacterial, antitumor and neuroprotective activities .

Species:	Human (2) Mouse (1)
Tag:	His (2) SUMO (1) Tag Free (1)
Source:	P. pastoris (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P7503

	Angiogenin Protein, Human rHuAngiogenin; ANG; RNASE5; Angiogenin	Human	E. coli
	Angiogenin Protein, Human is a potent inducer of new blood vessel formation. Angiogenin may contribute to the malignant transformation of gliomas as well as to angiogenic processes.

HY-P71826

	Angiogenin-4 Protein, Mouse (P.pastoris, His-SUMOstar) Ang4Angiogenin-4; EC 3.1.27.-	Mouse	P. pastoris
	The angiopoietin-4 protein has specific bactericidal activity against Enterococcus faecalis and Listeria monocytogenes, distinct from its lack of efficacy against Lactobacillus innocua and Escherichia coli. Furthermore, Angiogenin-4 exerts pro-angiogenic effects in vitro, suggesting its involvement in supporting the formation of new blood vessels. Angiogenin-4 Protein, Mouse (P.pastoris) is the recombinant mouse-derived Angiogenin-4 protein, expressed by P. pastoris , with N-6*His, N-SUMO labeled tag. The total length of Angiogenin-4 Protein, Mouse (P.pastoris) is 120 a.a., with molecular weight of ~33 kDa.

HY-P700644

	Angiogenin Protein,Human (His) rHuAngiogenin; ANG; RNASE5; Angiogenin	Human	E. coli
	Human angiopoietin protein is a ribonuclease that cleaves tRNA to generate stress-induced fragments, inhibits protein synthesis and triggers stress granule assembly. It binds to endothelial cell actin, undergoes endocytosis and nuclear translocation, and stimulates ribosomal RNA synthesis. Angiogenin Protein,Human (His) is the recombinant human-derived Angiogenin protein,Human, expressed by E. coli , with N-6*His labeled tag. The total length of Angiogenin Protein,Human (His) is 122 a.a., with molecular weight of 18.0 kDa.


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