Search Result

Pathways Recommended:	Membrane Transporter/Ion Channel
Targets Recommended:	Sodium Channel Potassium Channel Chloride Channel TRP Channel Calcium Channel HCN Channel CRAC Channel SGLT Na+/K+ ATPase VDAC

Results for "Anp 230 sodium channel Inhibitors" in MCE Product Catalog:

By Targets:	Calcium Channel (18) Chloride Channel (1) CRAC Channel (2) Na+/K+ ATPase (1) Potassium Channel (21) SGLT (1) Sodium Channel (24) TRP Channel (5) 5-HT Receptor (1) ADC Cytotoxin (2) ADC Linker (6) Adrenergic Receptor (2) Akt (1) Aldose Reductase (1) ALK (1) Angiotensin Receptor (2) Angiotensin-converting Enzyme (ACE) (2) Antibiotic (70) Apoptosis (28) Autophagy (28) Bacterial (79) Bcr-Abl (1) CaMK (1) Cannabinoid Receptor (1) Casein Kinase (2) Caspase (2) CD73 (1) CDK (1) CFTR (1) Cholecystokinin Receptor (2) COMT (1) COX (7) DNA Alkylator/Crosslinker (1) DNA Methyltransferase (1) DNA/RNA Synthesis (5) Drug Metabolite (2) DYRK (2) Elastase (2) Endogenous Metabolite (36) Endothelin Receptor (2) Ephrin Receptor (1) ERK (2) Factor Xa (5) Ferroptosis (3) FGFR (1) FLAP (2) Fungal (4) FXR (1) Gap Junction Protein (3) GLUT (1) GNRH Receptor (1) GPCR19 (1) GPR40 (2) GPR84 (1) GSK-3 (1) HCV (1) HCV Protease (1) HDAC (3) Histamine Receptor (3) HIV (11) HIV Integrase (1) HMG-CoA Reductase (HMGCR) (11) HSV (1) IFNAR (1) iGluR (3) Influenza Virus (3) Interleukin Related (2) Leukotriene Receptor (5) Lipoxygenase (1) LPL Receptor (1) mGluR (2) Microtubule/Tubulin (4) Mitochondrial Metabolism (1) Mitophagy (2) MMP (2) Na+/Ca2+ Exchanger (2) nAChR (1) NF-κB (1) NKCC (2) NOD-like Receptor (NLR) (2) Notch (1) Nucleoside Antimetabolite/Analog (1) P2X Receptor (3) P2Y Receptor (1) p38 MAPK (1) PAI-1 (1) Parasite (7) PDHK (1) PGE synthase (1) Phosphatase (7) Phosphodiesterase (PDE) (2) Phospholipase (1) PI3K (1) PKA (3) PKC (1) Polo-like Kinase (PLK) (1) PPAR (2) Prostaglandin Receptor (9) PROTAC Linker (1) Proton Pump (6) RAR/RXR (2) Reactive Oxygen Species (8) Reverse Transcriptase (3) SARS-CoV (2) Sirtuin (1) STAT (1) STING (3) TGF-β Receptor (1) Thrombin (2) Thyroid Hormone Receptor (2) Toll-like Receptor (TLR) (1) Topoisomerase (2) Tyrosinase (1) URAT1 (1) Virus Protease (2) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (91) Cardiovascular Disease (53) Endocrinology (25) Infection (94) Inflammation/Immunology (63) Metabolic Disease (50) Neurological Disease (60)

By Targets:

Calcium Channel (18)

Chloride Channel (1)

CRAC Channel (2)

Na+/K+ ATPase (1)

Potassium Channel (21)

SGLT (1)

Sodium Channel (24)

TRP Channel (5)

5-HT Receptor (1)

ADC Cytotoxin (2)

ADC Linker (6)

Adrenergic Receptor (2)

Akt (1)

Aldose Reductase (1)

ALK (1)

Angiotensin Receptor (2)

Angiotensin-converting Enzyme (ACE) (2)

Antibiotic (70)

Apoptosis (28)

Autophagy (28)

Bacterial (79)

Bcr-Abl (1)

CaMK (1)

Cannabinoid Receptor (1)

Casein Kinase (2)

Caspase (2)

CD73 (1)

CDK (1)

CFTR (1)

Cholecystokinin Receptor (2)

COMT (1)

COX (7)

DNA Alkylator/Crosslinker (1)

DNA Methyltransferase (1)

DNA/RNA Synthesis (5)

Drug Metabolite (2)

DYRK (2)

Elastase (2)

Endogenous Metabolite (36)

Endothelin Receptor (2)

Ephrin Receptor (1)

ERK (2)

Factor Xa (5)

Ferroptosis (3)

FGFR (1)

FLAP (2)

Fungal (4)

FXR (1)

Gap Junction Protein (3)

GLUT (1)

GNRH Receptor (1)

GPCR19 (1)

GPR40 (2)

GPR84 (1)

GSK-3 (1)

HCV (1)

HCV Protease (1)

HDAC (3)

Histamine Receptor (3)

HIV (11)

HIV Integrase (1)

HMG-CoA Reductase (HMGCR) (11)

HSV (1)

IFNAR (1)

iGluR (3)

Influenza Virus (3)

Interleukin Related (2)

Leukotriene Receptor (5)

Lipoxygenase (1)

LPL Receptor (1)

mGluR (2)

Microtubule/Tubulin (4)

Mitochondrial Metabolism (1)

Mitophagy (2)

MMP (2)

Na+/Ca2+ Exchanger (2)

nAChR (1)

NF-κB (1)

NKCC (2)

NOD-like Receptor (NLR) (2)

Notch (1)

Nucleoside Antimetabolite/Analog (1)

P2X Receptor (3)

P2Y Receptor (1)

p38 MAPK (1)

PAI-1 (1)

Parasite (7)

PDHK (1)

PGE synthase (1)

Phosphatase (7)

Phosphodiesterase (PDE) (2)

Phospholipase (1)

PI3K (1)

PKA (3)

PKC (1)

Polo-like Kinase (PLK) (1)

PPAR (2)

Prostaglandin Receptor (9)

PROTAC Linker (1)

Proton Pump (6)

RAR/RXR (2)

Reactive Oxygen Species (8)

Reverse Transcriptase (3)

SARS-CoV (2)

Sirtuin (1)

STAT (1)

STING (3)

TGF-β Receptor (1)

Thrombin (2)

Thyroid Hormone Receptor (2)

Toll-like Receptor (TLR) (1)

Topoisomerase (2)

Tyrosinase (1)

URAT1 (1)

Virus Protease (2)

Wnt (1)

β-catenin (1)

By Research Areas:

Cancer (91)

Cardiovascular Disease (53)

Endocrinology (25)

Infection (94)

Inflammation/Immunology (63)

Metabolic Disease (50)

Neurological Disease (60)

388

Inhibitors & Agonists

Dye Reagents

Biochemical Assay Reagents

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas

HY-101350

QX-314 bromide
Sodium Channel Neurological Disease

QX-314 bromide is a membrane-impermeable permanently charged sodium channel blocker.
HY-108505

QX-314 chloride
Sodium Channel Neurological Disease

QX-314 chloride is a membrane-impermeable permanently charged sodium channel blocker.

QX-314 bromide	Sodium Channel	Neurological Disease
QX-314 bromide is a membrane-impermeable permanently charged sodium channel blocker.

QX-314 chloride	Sodium Channel	Neurological Disease
QX-314 chloride is a membrane-impermeable permanently charged sodium channel blocker.

HY-B1243

Propoxycaine hydrochloride	Sodium Channel	Neurological Disease
Propoxycaine hydrochloride inhibits voltage-gated sodium channels, and thereby inhibits the ionic flux required for the initiation and conduction of impulses. Propoxycaine hydrochloride application can lead to a loss of sensation.

HY-U00439

Protein kinase inhibitors 1
DYRK Cancer

Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC₅₀ of 74 nM and K_d of 9.5 nM.

*Protein kinase inhibitors* 1**	DYRK	Cancer
Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC₅₀ of 74 nM and K_d of 9.5 nM.

HY-15736

Sodium Channel inhibitor 1	Sodium Channel	Neurological Disease
Sodium Channel inhibitor1, one of 3-Oxoisoindoline-1-carboxamides, is a novel and selective voltage-gated sodium channel for pain treatment.

HY-100257

Sodium Channel inhibitor 2
Sodium Channel Neurological Disease

Sodium Channel inhibitor 2 is a sodium channel blocker extracted from patent WO 2004011439 A2, compound 3c.

Sodium Channel inhibitor 2	Sodium Channel	Neurological Disease
Sodium Channel inhibitor 2 is a sodium channel blocker extracted from patent WO 2004011439 A2, compound 3c.

HY-16787

ICA-121431	Sodium Channel	Cardiovascular Disease
ICA-121431 is a nanomolar potent and broad-spectrum voltage-gated sodium channel (Na_v) blocker, shows equipotent selectivity for human Na_v1.1 and Na_v1.3 subtypes with IC₅₀ values of 13 nM and 23 nM, respectively. ICA-121431 shows less potent inhibition of Na_v1.2 (IC₅₀=240 nM) and 1,000 fold selectivity against Na_v1.4, Na_v1.6, and the TTX-resistant human Na_v1.5 and Na_v1.8 channels (IC₅₀s >10 µM).

HY-100973A

Adenosine 5′-diphosphoribose sodium ADP ribose sodium	TRP Channel Autophagy	Endocrinology Metabolic Disease
Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD⁺) metabolite. Adenosine 5′-diphosphoribose sodium is the most potent and primary intracellular Ca²⁺-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose sodium also can enhance autophagy.

HY-P1219A

Jingzhaotoxin-III TFA	Sodium Channel	Neurological Disease
Jingzhaotoxin-III TFA is a potent and selective blocker of Nav1.5 channels, with an IC₅₀ of 348 nM, and shows no effect on other sodium channel isoforms. Jingzhaotoxin-III TFA can selectively inhibit the activation of cardiac sodium channel but not neuronal subtypes, and hopefully represents an important ligand for discriminating cardiac VGSC subtype^{[1]^{^{[2]^.}}}

HY-P1219

Jingzhaotoxin-III	Sodium Channel	Neurological Disease
Jingzhaotoxin-III is a potent and selective blocker of Nav1.5 channels, with an IC₅₀ of 348 nM, and shows no effect on other sodium channel isoforms. Jingzhaotoxin-III can selectively inhibit the activation of cardiac sodium channel but not neuronal subtypes, and hopefully represents an important ligand for discriminating cardiac VGSC subtype^{[1]^{^{[2]^.}}}

HY-130187A

Sapienic acid sodium	Bacterial	Infection
Sapienic acid sodium is a fatty acid commonly found on the skin and in mucosa. Sapienic acid sodium has variable antimicrobial activities against Gram-positive and Gram-negative bacteria found on the skin and in the oral cavity. Sapienic acid sodium is active against *Streptococcus sanguinis, Streptococcus mitis* and *Fusobacterium nucleatum* with MBC values of 31.3 μg/mL, 375.0 μg/mL and 93.8 μg/mL, respectively.

HY-16952A

Bepridil hydrochloride hydrate (±)-Bepridil hydrochloride hydrate; Org 5730 hydrochloride hydrate	Calcium Channel	Cardiovascular Disease
Bepridil hydrochloride hydrate ((±)-Bepridil hydrochloride hydrate) is a non-selective, long-acting Ca⁺ channel antagonist and Na⁺, K⁺ channel inhibitor, with antianginal and type I antiarrhythmic effects. Bepridil hydrochloride hydrate also acts as a cardiac Na⁺/Ca2⁺ exchange (NCX1) inhibitor. Bepridil hydrochloride hydrate can be used for the research of cardiovascular disorders.

HY-U00135

Calcium channel-modulator-1
Calcium Channel Cardiovascular Disease

Calcium channel-modulator-1 is a calcium channel modulator; blocks aortic contraction with an IC₅₀ of 0.8 μM.

*Calcium channel-modulator-1*	Calcium Channel	Cardiovascular Disease
Calcium channel-modulator-1 is a calcium channel modulator; blocks aortic contraction with an IC₅₀ of 0.8 μM.

HY-P1218

Phrixotoxin 3	Sodium Channel	Neurological Disease
Phrixotoxin 3 is a potent blocker of voltage-gated sodium channels, with IC₅₀s of 0.6, 42, 72, 288, 610 nM for NaV1.2, NaV1.3, NaV1.4, NaV1.1 and NaV1.5, respectively. Phrixotoxin 3 modulates voltage-gated sodium channels with properties similar to those of typical gating-modifier toxins, both by causing a depolarizing shift in gating kinetics and by blocking the inward component of the sodium current^{[1]^.}

HY-P1218A

Phrixotoxin 3 TFA	Sodium Channel	Neurological Disease
Phrixotoxin 3 TFA is a potent blocker of voltage-gated sodium channels, with IC₅₀s of 0.6, 42, 72, 288, 610 nM for NaV1.2, NaV1.3, NaV1.4, NaV1.1 and NaV1.5, respectively. Phrixotoxin 3 TFA modulates voltage-gated sodium channels with properties similar to those of typical gating-modifier toxins, both by causing a depolarizing shift in gating kinetics and by blocking the inward component of the sodium current^{[1]^.}

HY-75867

M2 ion channel blocker
Influenza Virus Infection

M2 ion channel blocker is capable of inhibiting and blocking the activity of M2 ion channel;Antiviral agent.

*M2 ion channel* blocker**	Influenza Virus	Infection
M2 ion channel blocker is capable of inhibiting and blocking the activity of M2 ion channel;Antiviral agent.

HY-100310

*N-type calcium channel* blocker-1**	Calcium Channel	Neurological Disease
N-type calcium channel blocker-1 is an orally active analgesic agent which shows high affinity to functionally block N-type calcium channels with an IC₅₀ of 0.7 μM in the IMR32 assay.

HY-U00280

*Potassium Channel* Activator 1**	Others	Neurological Disease
Potassium Channel Activator 1 is an agent for treating, one or more disorders or conditions wherein the dopaminergic system is disrupted, such as one or more disorders or conditions independently selected from the group consisting of: schizophrenia and other psychotic states; mood disorders ADHD; aggression; movement disorders.

HY-131005

Ehp inhibitor 2
Ephrin Receptor Cancer

Ehp inhibitor 2 is a Eph family tyrosine kinase inhibitor.

Ehp inhibitor 2	Ephrin Receptor	Cancer
Ehp inhibitor 2 is a Eph family tyrosine kinase inhibitor.

HY-41076

*Ca2+ channel* agonist 1**	Calcium Channel CDK	Neurological Disease
Ca²⁺ channel agonist 1 is an agonist of N-type Ca²⁺ channel and an inhibitor of Cdk2, with EC₅₀s of 14.23 μM and 3.34 μM, respectively, and is used as a potential treatment for motor nerve terminal dysfunction.

HY-P1220

Huwentoxin-IV	Sodium Channel	Neurological Disease
Huwentoxin-IV is a potent and selective sodium channel blocker, inhibits neuronal Nav1.7, Nav1.2, Nav1.3 and Nav1.4 with IC₅₀s of 26, 150, 338 and 400 nM, respectively. Huwentoxin-IV preferentially blocks peripheral nerve subtype Nav1.7 by binding neurotoxin receptor site 4. Huwentoxin-IV has analgesic effects on animal models of inflammatory and neuropathic pain^{[1]^{^{[2]^.}}}

HY-P1220A

Huwentoxin-IV TFA	Sodium Channel	Neurological Disease
Huwentoxin-IV TFA is a potent and selective sodium channel blocker, inhibits neuronal Nav1.7, Nav1.2, Nav1.3 and Nav1.4 with IC₅₀s of 26, 150, 338 and 400 nM, respectively. Huwentoxin-IV TFA preferentially blocks peripheral nerve subtype Nav1.7 by binding neurotoxin receptor site 4. Huwentoxin-IV TFA has analgesic effects on animal models of inflammatory and neuropathic pain^{[1]^{^{[2]^.}}}

HY-121879

SHP836
Phosphatase Cancer

SHP836 is a SHP2 allosteric inhibitor, with an IC₅₀ of 12 μM for the full length SHP2.

SHP836	Phosphatase	Cancer
SHP836 is a SHP2 allosteric inhibitor, with an IC₅₀ of 12 μM for the full length SHP2.

HY-19373

RWJ-445167 3DP-10017	Thrombin Factor Xa	Cardiovascular Disease
RWJ-445167 (3DP-10017) is a dual inhibitor of thrombin and factor Xa with K_i of 4.0 nM and 230 nM, respectively, exhibiting potent antithrombotic activity.

HY-B0035A

Sulfamethazine sodium Sulfadimidine sodium; Sulfadimerazine sodium	Bacterial Antibiotic	Infection
Sulfamethazine sodium (Sulfadimidine sodium) is an antimicrobial that is widely used to treat and prevent various animal diseases (such as gastrointestinal and respiratory tract infections). In China and the European Commission, the maximum residue level for Sulfamethazine sodium in animal product is set at 100 µg/kg.

HY-B1078

Cefazolin sodium sodium cefazolin; sodium cephazolin	Bacterial Antibiotic	Infection
Cefazolin sodium is a first-generation cephalosporin antibiotic, useful for the treatment of a number of bacterial infections.

HY-B1484

*Moxalactam sodium* salt** Latamoxef sodium; Lamoxactam sodium; LY-127935 sodium	Bacterial Antibiotic	Infection
Moxalactam sodium salt (Latamoxef sodium) is an antibiotic compound more effective against Escherichia coli and Pseudomonas aeruginosathan cephalosporins.

HY-17439

*Salinomycin sodium* salt** Salinomycin sodium; sodium salinomycin	Wnt β-catenin Bacterial Autophagy Apoptosis Antibiotic	Cancer
Salinomycin sodium salt (Salinomycin sodium), an antibiotic potassium ionophore, is a potent inhibitor of Wnt/β-catenin signaling. Salinomycin sodium salt (Salinomycin sodium) acts on the Wnt/Fzd/LRP complex, blocks Wnt-induced LRP6 phosphorylation, and causes degradation of the LRP6 protein. Salinomycin sodium salt (Salinomycin sodium) shows selective activity against human cancer stem cells.

HY-17567A

*Heparin sodium* salt** sodium heparin; sodium heparinate	Autophagy	Others
Heparin sodium salt (Sodium heparin) is an anticoagulant which binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin factor IIa and factor Xa.

HY-U00439A

*Protein kinase inhibitors* 1 hydrochloride** (E)-5-((2-Oxo-6'-(piperazin-1-yl)-1,2-dihydro-[3,3'-bipyridin]-5-yl)methylene)thiazolidine-2,4-dione hydrochloride	DYRK	Cancer
Protein kinase inhibitors 1 hydrochloride is a potent HIPK2 inhibitor, with IC₅₀s of 136 and 74 nM for HIPK1 and HIPK2, and a K_d of 9.5 nM for HIPK2.

HY-D0852

Sodium orthovanadate sodium vanadate	Phosphatase	Cancer
Sodium orthovanadate is an inhibitor of protein tyrosine phosphatases, alkaline phosphatases and a number of ATPases, most likely acting as a phosphate analogue.

HY-B1275

Cephalothin sodium Cefalotin sodium	Bacterial Antibiotic	Infection
Cephalothin sodium is a first generation cephem antibiotic with a wide range antibacterial activity, is active against gram-positive and gram-negative bacteria.

HY-B1257

Cefmetazole sodium
sodium cefmetazole
Bacterial Antibiotic Infection

Cefmetazole sodium is a semisynthetic cephamycin antibiotic.
HY-N1427

Glycodeoxycholate Sodium
sodium glycyldeoxycholate
Endogenous Metabolite Metabolic Disease

Glycodeoxycholate Sodium is a bile salt.

Cefmetazole sodium sodium cefmetazole	Bacterial Antibiotic	Infection
Cefmetazole sodium is a semisynthetic cephamycin antibiotic.

Glycodeoxycholate Sodium sodium glycyldeoxycholate	Endogenous Metabolite	Metabolic Disease
Glycodeoxycholate Sodium is a bile salt.

HY-B2191

Sodium gualenate Guaiazulenesulfonate sodium	Others	Inflammation/Immunology
Sodium gualenate (Guaiazulenesulfonate sodium) is a hydrophilic derivative of guaiazulene with excellent anti-inflammatory and wound-healing effects mainly used for the treatment of duodenal ulcer, gastric ulcer and gastritis.

HY-B0544

Sodium Picosulfate
sodium Picosulphate
Others Metabolic Disease

Sodium Picosulfate inhibits absorption of water and electrolytes, and increases their secretion.
HY-B0998

Dehydrocholate sodium
sodium dehydrocholate
Endogenous Metabolite Others

Dehydrocholic sodium is a hydrocholeretic, increasing bile output to clear increased bile acid load.

Sodium Picosulfate sodium Picosulphate	Others	Metabolic Disease
Sodium Picosulfate inhibits absorption of water and electrolytes, and increases their secretion.

Dehydrocholate sodium sodium dehydrocholate	Endogenous Metabolite	Others
Dehydrocholic sodium is a hydrocholeretic, increasing bile output to clear increased bile acid load.

HY-19285A

Sulfaclozine sodium Sulfachloropyrazine sodium	Bacterial Parasite Antibiotic	Infection
Sulfaclozine sodium (Sulfachloropyrazine sodium) is an efficacious sulphonamide derivative with antibacterial and anticoccidial effects. Sulfaclozine sodium is commonly used for the treatment of various poultry diseases (particularly, collibacteriosis, fowl cholera and coccidiosis).

HY-N7096

Ceftezole sodium CTZ sodium	Bacterial Antibiotic	Infection
Ceftezole sodium (CTZ sodium) is a broad-spectrum cephem antibiotic against many species of gram-positive and gram-negative bacteria. Ceftezole sodium (CTZ sodium) is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity.

HY-B0337A

Sulfadimethoxine sodium Sulphadimethoxine sodium	Bacterial Antibiotic	Infection
Sulfadimethoxine sodium (Sulphadimethoxine sodium) is a sulfonamide antibiotic used to treat many infections.

HY-B1286

Piperacillin sodium
sodium piperacillin
Bacterial Antibiotic Infection

Piperacillin sodium is a broad-spectrum β-lactam antibiotic.
HY-B0898

Ceftiofur sodium
sodium ceftiofur
Bacterial Antibiotic Infection

Ceftiofur sodium is an antibiotic of the cephalosporin type (third generation), licensed for use in veterinary medicine.

Piperacillin sodium sodium piperacillin	Bacterial Antibiotic	Infection
Piperacillin sodium is a broad-spectrum β-lactam antibiotic.

Ceftiofur sodium sodium ceftiofur	Bacterial Antibiotic	Infection
Ceftiofur sodium is an antibiotic of the cephalosporin type (third generation), licensed for use in veterinary medicine.

HY-23119

Sodium thiocyanate Thiocyanate sodium	Interleukin Related Reactive Oxygen Species	Inflammation/Immunology
Sodium thiocyanate reduces plasma levels of the pro-inflammatory cytokine IL-6, and increases the anti-inflammatory cytokine IL-10 levels. Sodium thiocyanate also significantly reduces of ROS formation.

HY-A0153A

Cephapirin sodium Cefapirin sodium	Bacterial Antibiotic	Infection
Cephapirin sodium (Cefapirin sodium), a semisynthetic cephalosporin antibiotic, is bactericidal against strains of gram-positive and gram-negative bacteria.

HY-B0467

Amoxicillin sodium
Amoxycillin sodium
Bacterial Antibiotic Infection

Amoxicillin sodium (Amoxycillin sodium) is a moderate- spectrum, bacteriolytic, β-lactam antibiotic.

Amoxicillin sodium Amoxycillin sodium	Bacterial Antibiotic	Infection
Amoxicillin sodium (Amoxycillin sodium) is a moderate- spectrum, bacteriolytic, β-lactam antibiotic.

HY-B1637

Ditiocarb sodium sodium diethyldithiocarbamate	HIV	Infection
Ditiocarb sodium (Sodium diethyldithiocarbamate) is an accelerator of the rate of copper cementation. Sodium diethyldithiocarbamate reduces the incidence of HIV infection.

HY-B1128A

Cefamandole sodium
Cephamandole sodium
Bacterial Antibiotic Others

Cefamandole Sodium Salt is a second-generation broad-spectrum cephalosporin antibiotic.

Cefamandole sodium Cephamandole sodium	Bacterial Antibiotic	Others
Cefamandole Sodium Salt is a second-generation broad-spectrum cephalosporin antibiotic.

HY-111391

Resazurin sodium Diazoresorcinol sodium	Bacterial	Others
Resazurin sodium (Diazoresorcinol sodium) is commonly used to measure bacterial and eukaryotic cell viability through its reduction to the fluorescent product resorufin.

HY-W012037

8-Hydroxyquinoline hemisulfate 8-Quinolinol hemisulfate	Bacterial Antibiotic	Infection
8-Hydroxyquinoline hemisulfate (8-Quinolinol hemisulfate) is a monoprotic bidentate chelating agent, exhibits antiseptic, disinfectant, and pesticide properties, functioning as a transcription inhibitor.

HY-B0926A

Sodium diatrizoate
Diatrizoic acid sodium salt; sodium amidotrizoate
Others Others

Sodium diatrizoate is an iodinated radiocontrast agent.

HY-15229

Guadecitabine sodium SGI-110 sodium; S-110 sodium	DNA Methyltransferase	Cancer
Guadecitabine sodium (SGI-110 sodium) is a second-generation DNA methyltransferases (DNMT) inhibitor for research of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS).

HY-19696A

Tauroursodeoxycholate Sodium sodium tauroursodeoxycholate; Tauroursodeoxycholic acid sodium salt	ERK Caspase	Cancer
Tauroursodeoxycholate Sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-N0106

Danshensu sodium salt
sodium Danshensu; (±)-DanShenSu sodium sal
Autophagy Cancer

Danshensu (sodium salt) is odium salt of danshensu from the widely used Chinese herb Danshen.

HY-17507A

Pantoprazole sodium BY1023 sodium; SKF96022 sodium	Proton Pump Autophagy Apoptosis	Cancer
Pantoprazole sodium (BY1023 sodium; SKF96022 sodium) is a proton pump inhibitor drug used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.

HY-B0612D

(R)-Lercanidipine hydrochloride	Calcium Channel	Cardiovascular Disease
(R)-Lercanidipine hydrochloride is the R-enantiomer of Lercanidipine. (R)-lercanidipine hydrochloride is a calcium channel blocker.

HY-W016420

Fosfomycin sodium MK-0955 sodium	Bacterial Antibiotic	Infection
Fosfomycin sodium (MK-0955 sodium) is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin sodium shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria.

HY-B1320

Meclofenamate sodium Meclofenamic acid sodium	Gap Junction Protein	Inflammation/Immunology
Meclofenamic acid sodium is a nonsteroidal anti-inflammatory drug (NSAID) approved for use in arthritis (osteo and rheumatoid), analgesia (mild to moderate pain), dysmenorrhea, and heavy menstrual blood loss (menorrhagia). Meclofenamic acid sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat mass and obesity-associated (FTO) enzyme inhibitor.

HY-15579B

MMAF sodium Monomethylauristatin F sodium	Microtubule/Tubulin ADC Cytotoxin	Cancer
MMAF sodium (Monomethylauristatin F sodium) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF sodium (Monomethylauristatin F sodium) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A.

HY-13402A

Varespladib sodium LY315920 sodium	Phospholipase	Inflammation/Immunology
Varespladib sodium (LY315920 sodium) is a potent and selective group IIA, secretory phospholipase A₂ (sPLA₂) inhibitor with an IC₅₀ of 9 nM. Varespladib sodium exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC₅₀s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively.

HY-A0166A

Cilastatin sodium MK0791 sodium	Bacterial Antibiotic	Infection
Cilastatin sodium (MK0791 sodium) is a reversible, competitive renal dehydropeptidase I inhibitor with an IC₅₀ of 0.1 μM. Cilastatin sodium inhibits the bacterial metallob-lactamase enzyme CphA with an IC₅₀ of 178 μM. Cilastatin sodium is an antibacterial adjunct.

HY-50714

Quiflapon sodium MK-591 sodium	FLAP Apoptosis	Inflammation/Immunology
Quiflapon sodium (MK-591 sodium) is a selective and specific 5-Lipoxygenase-activating protein (FLAP) inhibitor. Quiflapon sodium is an orally active Leukotriene biosynthesis inhibitor. Induces apoptosis.

HY-15342A

Timapiprant sodium OC000459 sodium	Prostaglandin Receptor	Inflammation/Immunology Endocrinology
Timapiprant sodium (OC000459 sodium) is a potent, selective, and orally active D prostanoid receptor 2 (DP₂, also known as CRTH2) antagonist. Timapiprant sodium (OC000459 sodium) potently displaces [³H] PGD2 from human recombinant DP₂ (K_i=13 nM), rat recombinant DP₂ (K_i=3 nM), and human native DP₂ (K_i=4 nM). Timapiprant sodium (OC000459 sodium) inhibits mast cell activation of Th2 lymphocytes and eosinophils.

HY-B1907

Rifamycin sodium Rifamycin SV sodium	Bacterial Antibiotic	Infection
Rifamycin sodium (Rifamycin SV monosodium) belongs to the family of ansamycin antibiotics and has been isolated from the fermentation of A. mediterranei or its mutants. Rifamycin sodium displays a broad spectrum of antibiotic activity against Gram-positive and, to a lesser extent, Gram-negative bacteria.

HY-17421A

Tenatoprazole sodium Tenatoprazole sodium salt	Proton Pump	Cardiovascular Disease
Tenatoprazole sodium (TU-199 sodium) is a proton pump inhibitor; inhibits hog gastric H⁺/K⁺-ATPase with an IC₅₀ of 6.2 μM.

HY-B0119

Risedronate sodium
Risedronic Acid sodium
Others Others

Risedronate sodium is a pyridinyl biphosphonate which inhibits osteoclast-mediated bone resorption.
HY-14369

Elagolix sodium
NBI-56418 sodium
GNRH Receptor Endocrinology Cancer

Elagolix sodium is a human GnRH receptor (GnRHR) antagonist with an IC₅₀ and K_i of 0.25 and 3.7 nM, respectively.

HY-14854A

Tecarfarin sodium ATI-5923 sodium	Others	Metabolic Disease
Tecarfarin sodium (ATI-5923 sodium) is a novel orally active non-competitive vitamin K epoxide reductase (VKOR) antagonist, impairs the activation of the vitamin K-dependent clotting factors II, VII, IX and X. Tecarfarin sodium has the antithrombotic activity.

HY-128467

Dehydroacetic acid sodium sodium dehydroacetate	Bacterial Fungal	Infection
Dehydroacetic acid sodium, a pyrone derivative acts as an antibacterial and antifungal agent. Dehydroacetic acid possess phytotoxic activity.

HY-B0656A

Rabeprazole sodium LY307640 sodium	Proton Pump Apoptosis	Inflammation/Immunology Cancer
Rabeprazole sodium (LY307640 sodium) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H⁺/K⁺-ATPase. Rabeprazole sodium induces apoptosis. Rabeprazole sodium acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC₅₀ of 0.3 μM. Rabeprazole sodium can be used for the research of gastric ulcerations and gastroesophageal reflux.

HY-B0633

Hyaluronic acid sodium sodium hyaluronate	Others	Cancer
Hyaluronic acid sodium (Sodium hyaluronate) is a biopolymer composed of repeating units of disaccharides with various applications.

HY-F0002

NADP sodium salt
sodium NADP
Others Others

NADP sodium salt is a coenzyme that is widely distributed in living matter.
HY-B0428A

Ozagrel sodium
OKY-046 sodium
Factor Xa Cardiovascular Disease

Ozagrel sodium (OKY-046 sodium) is an antiplatelet agent working as a thromboxane A2 synthesis inhibitor.
HY-13662A

Lansoprazole sodium
AG-1749 sodium
Proton Pump Inflammation/Immunology

Lansoprazole sodium(AG-1749) is a proton pump inhibitor which prevents the stomach from producing acid.

HY-13619A

Efaproxiral sodium RSR13 sodium	Reactive Oxygen Species	Cancer
Efaproxiral sodium (RSR13 sodium) is a synthetic allosteric modifier of haemoglobin (Hb), decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy.

HY-B0974

*Methicillin sodium* salt** Meticillin sodium	Bacterial Antibiotic	Infection
Methicillin sodium salt (Meticillin sodium) is a β-lactam antibiotic which acts by inhibiting penicillin-binding proteins that are involved in the synthesis of peptidoglycan.

HY-17023

Esomeprazole sodium (S)-Omeprazole sodium	Proton Pump	Endocrinology
Esomeprazole sodium is a proton pump inhibitor which reduces acid secretion through inhibition of the H+ / K+ ATPase in gastric parietal cells.

HY-15258A

Lesinurad sodium RDEA-594 sodium	URAT1	Metabolic Disease
Lesinurad sodium is a URAT1 and OAT inhibitor, is determined to be a substrate for the kidney transporters OAT1 and OAT3 with K_m values of 0.85 and 2 µM, respectively.

HY-B0165A

Pravastatin sodium CS-514 sodium	HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis	Cardiovascular Disease Cancer
Pravastatin sodium (CS-514 sodium) is an HMG-CoA reductase inhibitor against sterol synthesis with IC₅₀ of 5.6 μM.

HY-13563A

Batabulin sodium T138067 sodium	Microtubule/Tubulin Apoptosis	Cancer
Batabulin sodium (T138067 sodium) is an antitumor agent, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin sodium affects cell morphology and leads to cell-cycle arrest ultimately induce apoptotic cell death. Batabulin sodium has efficacy against multidrug-resistant (MDR) tumors.

HY-12037

Rigosertib sodium ON-01910 sodium	Polo-like Kinase (PLK) PI3K Apoptosis	Cancer
Rigosertib sodium (ON-01910 sodium) is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3K/Akt pathway, promotes the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle. Rigosertib sodium is a selective and non-ATP-competitive inhibitor of PLK1 with an IC₅₀ of 9 nM.

HY-B0529A

Azlocillin sodium salt
sodium azlocillin
Bacterial Antibiotic Infection

Azlocillin is an acylampicillin with a broad spectrum against bacteria.

HY-15874A

Fiboflapon sodium GSK2190915 sodium salt; AM-803 sodium	FLAP Leukotriene Receptor	Inflammation/Immunology
Fiboflapon sodium (GSK2190915; AM-803) is a potent and orally bioavailable 5-lipoxygenase-activating protein (FLAP) inhibitor with a potency of 2.9 nM in FLAP binding, an IC₅₀ of 76 nM for inhibition of LTB4 in human blood.

HY-N2334A

*Glycochenodeoxycholic acid sodium* salt** Chenodeoxycholylglycine sodium salt; sodium glycochenodeoxycholate	Endogenous Metabolite Apoptosis	Cancer
Glycochenodeoxycholic acid sodium salt (Chenodeoxycholylglycine sodium salt) is a bile acid formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Glycochenodeoxycholic acid sodium salt (Chenodeoxycholylglycine sodium salt) induces hepatocyte apoptosis.

HY-B0764

Bucladesine sodium Dibutyryl cAMP sodium salt; DBcAMP sodium salt	PKA Phosphodiesterase (PDE)	Inflammation/Immunology
Bucladesine sodium salt (Dibutyryl-cAMP sodium salt) is a stabilized cyclic AMP (cAMP) analog and a selective PKA activator. Bucladesine sodium salt raises the intracellular levels of cAMP. Bucladesine sodium salt is also a phosphodiesterase (PDE) inhibitor. Bucladesine sodium salt has anti-inflammatory activity and can be used for impaired wound healing.

HY-17443A

Sivelestat sodium ONO5046-Na; sodium sivelestat; EI546 sodium; LY544349 sodium	Elastase	Cancer
Sivelestat sodium(ONO5046; LY544349; EI546) is a competitive inhibitor of human neutrophil elastase(IC50 = 44 nM; Ki=200 nM); also inhibited leukocyte elastase obtained from rabbit, rat, hamster and mouse.

HY-15654

Sodium 4-phenylbutyrate 4-Phenylbutyric acid sodium; 4-PBA sodium; Benzenebutyric acid sodium	HDAC Autophagy Apoptosis	Cancer
Sodium 4-phenylbutyrate (4-Phenylbutyric acid sodium) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.

HY-B0739A

Citicoline sodium Cytidine diphosphate-choline sodium; CDP-Choline sodium; Cytidine 5'-diphosphocholine sodium	Endogenous Metabolite Apoptosis	Neurological Disease
Citicoline sodium salt is an intermediate in the synthesis of phosphatidylcholine which is a component of cell membranes and also exerts neuroprotective effects.

HY-B1092A

Gluconate sodium D-Gluconic acid sodium salt; sodium D-gluconate; D-Gluconate sodium salt	Endogenous Metabolite	Others
Gluconate sodium (D-Gluconic acid sodium salt) is a corrosion and scale inhibitor of ordinary steel in simulated cooling water.

HY-A0070

Liothyronine sodium Triiodothyronine sodium; 3,3',5-Triiodo-L-thyronine sodium; T3 sodium	Thyroid Hormone Receptor	Cancer Endocrinology
Liothyronine sodium is an active form of thyroid hormone, which binds to β1 thyroid hormone receptor (TRβ1), and activates its activity.

HY-135813

LtaS-IN-1	Bacterial	Infection
LtaS-IN-1 (compound 1771) is a potent small-molecule inhibitor of Lipoteichoic acid (LTA) synthesis in multidrug-resistant (MDR) E. faecium and by altering the cell wall morphology. LtaS-IN-1 alone inhibits Enterococcus.spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 combination with antibiotics abolishs multidrug-resistant E. faecium growth almost completely.

HY-125957

A-3 hydrochloride	PKA Casein Kinase CaMK PKC	Others
A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It against PKA (K_i=4.3 µM), casein kinase II (K_i=5.1 µM) and myosin light chain kinase (MLCK) (K_i=7.4 µM). A-3 hydrochloride also inhibits PKC and casein kinase I with K_i values of 47 µM and 80 µM, respectively.

HY-12815A

MCC950 sodium CP-456773 sodium; CRID3 sodium salt	NOD-like Receptor (NLR)	Inflammation/Immunology
MCC950 sodium (CP-456773 sodium; CRID3 sodium salt) is a potent, selective NLRP3 inhibitor with IC₅₀s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively.

HY-N7079A

Sodium erythorbate D-Isoascorbic acid sodium; D-Araboascorbic acid sodium	Others	Cancer
Sodium erythorbate (D-Isoascorbic acid sodium), produced from sugars derived from different sources, such as beets, sugar cane, and corn, is a food additive used predominantly in meats, poultry, and soft drinks.

HY-A0080

Aminohippurate sodium sodium p-aminohippurate; p-Aminohippuric acid sodium salt	Others	Others
Aminohippurate sodium is a diagnostic agent useful in medical tests involving the kidney used in the measurement of renal plasma flow.

HY-11103

Sitaxsentan sodium IPI 1040 sodium; TBC11251 sodium	Endothelin Receptor	Cardiovascular Disease Endocrinology
Sitaxsentan sodium (IPI 1040 sodium; TBC11251 sodium) is an orally active, highly selective antagonist of endothelin A receptors.

HY-A0088

*Cefotaxime sodium* salt** Cefotaxim sodium salt; HR-756 sodium salt	Bacterial Antibiotic	Infection
Cefotaxime sodium salt is a third-generation cephalosporin antibiotic; broad-spectrum antibiotic with activity against numerous Gram-positive and Gram-negative bacteria.

HY-B0430A

D-Pantothenic acid sodium sodium pantothenate; Vitamin B5 sodium	Apoptosis	Metabolic Disease
D-Pantothenic acid sodium (Sodium pantothenate) is an essential trace nutrient that functions as the obligate precursor of coenzyme A (CoA). D-Pantothenic acid sodium plays key roles in myriad biological processes, including many that regulate carbohydrate, lipid, protein, and nucleic acid metabolism.

HY-B0195A

Tranilast sodium MK-341 sodium; SB 252218 sodium	Prostaglandin Receptor Angiotensin Receptor	Inflammation/Immunology Endocrinology
Tranilast sodium (MK-341 sodium) acts as an anti-atopic agent. Tranilast suppresses production of prostaglandin D2 (PGD2, IC₅₀= 0.1 mM). Tranilast sodium exhibits anti-inflammatory and immunomodulatory effects. Tranilast sodium antagonizes angiotensin II and inhibits its biological effects in vascular smooth muscle cells.

HY-B1268

Docusate Sodium Dioctyl sulfosuccinate sodium salt	HSV	Others
Docusate Sodium (Dioctyl sulfosuccinate sodium salt) is a laxative used to for the research of constipation, for constipation due to the use of opiates it maybe used with a stimulant laxative, can be taken by mouth or rectally.

HY-13238A

Dolutegravir sodium S/GSK1349572 sodium	HIV Integrase HIV	Infection
Dolutegravir sodium (S/GSK1349572 sodium) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC₅₀ of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir sodium (S/GSK1349572 sodium) inhibits HIV-1 viral replication with an IC₅₀ of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir sodium (S/GSK1349572 sodium) retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC₅₀=3.6-5.8 nM).

HY-B0116A

Stavudine sodium
d4T sodium
HIV Reverse Transcriptase Infection

Stavudine sodium is a nucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.

HY-B0350A

Sodium Butyrate Butanoic acid sodium salt	HDAC Autophagy Apoptosis	Cancer
Sodium Butyrate (Butanoic acid sodium salt) is a histone deacetylase (HDAC) inhibitor, with anti-tumor effects in several cancers.

HY-12542A

*Dantrolene sodium* hemiheptahydrate** Dantrolene sodium hydrate	Calcium Channel Autophagy	Others
Dantrolene sodium hemiheptahydrate is a skeletal muscle relaxant which acts by blocking muscle contraction beyond the neuromuscular junction.

HY-B0322A

Sulfamethoxazole sodium Ro 4-2130 sodium	Bacterial Antibiotic	Infection
Sulfamethoxazole sodium (Ro 4-2130 sodium) is a sulfonamide bacteriostatic antibiotic. Sulfamethoxazole sodium is used to treat various urinary tract pathogens and in combination with Trimethoprim is considered the gold standard in the treatment of urinary tract infections (UTIs).

HY-B0107A

Acitretin sodium Ro 10-1670 sodium	RAR/RXR Autophagy	Inflammation/Immunology
Acitretin sodium(Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis.

HY-103259

Sodium metatungstate sodium polyoxotungstate; POM-1	Phosphatase	Neurological Disease
Sodium metatungstate (Sodium polyoxotungstate) is a potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitor, with K_i values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1, NTPDase 3 and NTPDase 2 respectively. Sodium metatungstate inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition.

HY-N0060A

Ferulic acid sodium Coniferic acid sodium	FGFR Endogenous Metabolite Reactive Oxygen Species	Cardiovascular Disease Cancer
Ferulic acid sodium is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC₅₀s of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively.

HY-N0593A

*Deoxycholic acid sodium* salt** sodium deoxycholate	GPCR19 Endogenous Metabolite	Metabolic Disease
Deoxycholic acid sodium salt is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.

HY-10585A

*Valproic acid sodium* salt** sodium Valproate	HDAC Autophagy Mitophagy HIV Notch	Cancer
Valproic acid sodium salt (Sodium Valproate) is an HDAC inhibitor, with IC₅₀ in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC₅₀, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium salt activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.

HY-120601

Alizarin Red S sodium
ARS sodium
Others Others

Alizarin Red S sodium (ARS sodium) is an anthraquinone dye that has been widely used to evaluate calcium deposits in cell culture.

HY-B2119

Sodium tauroglycocholate Tauroglycocholic acid sodium salt	Others	Endocrinology
Sodium tauroglycocholate is an inhibitor of the biliary acid transporting system of the hepatocyte and also a surfactant used as a chemical permeation enhancer.

HY-103354

Proglumide sodium	Cholecystokinin Receptor	Cancer Endocrinology Neurological Disease
Proglumide sodium is a nonpeptide and orally active cholecystokinin (CCK)-A/B receptors antagonist. Proglumide sodium selective blocks CCK’s effects in the central nervous system (CNS). Proglumide sodium has ability to inhibit gastric secretion and to protect the gastroduodenal mucosa. Proglumide sodium also has antiepileptic and antioxidant activities.

HY-17596A

Closantel sodium
Parasite Infection

Closantel is a salicylanilide anthelmintic compound; exhibits different anthelmintic spectra and apparent toxicity in mammals.

HY-B0576

Sulfacetamide Sodium	Bacterial Antibiotic	Infection
Sulfacetamide Sodium is an anti-infective agent that is used topically to treat skin infections and orally for urinary tract infections.

HY-N2501

Sodium Demethylcantharidate
Endogenous Metabolite Metabolic Disease

Sodium Demethylcantharidate is an endogenous metabolite.

HY-B1459

Dicloxacillin sodium	Bacterial Antibiotic	Infection
Dicloxacillin sodium is a narrow-spectrum β-lactam antibiotic of the penicillin family. Dicloxacillin sodium is active against β-lactamase-producing organisms such as Staphylococcus aureus.

HY-B0515B

Ibandronate Sodium
Others Metabolic Disease

Ibandronate Sodium is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis.

HY-126396

Sordarin sodium	Fungal Antibiotic	Infection Inflammation/Immunology
Sordarin is a potent diphthamide-dependent eEF2 inhibitor with antifungal properties. Sordarin targets eEF2 so as to inhibit protein translation by blocking eEF2-mediated translocation of tRNAs. Sordarin inhibits translation specifically in certain fungi (e.g. C. albicans, C. glabrata, and C. neoformans) while unable to do so in some other fungal species (e.g. Candida parapsilosis and Candida lusitaniae).

HY-76260

Faropenem sodium
Bacterial Antibiotic Infection

Faropenem sodium is an orally bioavailable penem antibiotic which can efficiently kill Mycobacterium tuberculosis.
HY-B1300

Cefonicid sodium
Bacterial Antibiotic Infection

Cefonicid sodium is a broadspectrum cephalosporin antibiotic which inhibits the formation of the bacterial cell wall.
HY-B1466

Mezlocillin sodium
Bacterial Antibiotic Infection

Mezlocillin sodium is a broad-spectrum penicillin antibiotic.
HY-13588

Cefsulodin sodium
Bacterial Antibiotic Infection

Cefsulodin sodium salt hydrate is a third generation β lactam antibiotic and member of the cephems subgroub of antibiotics.
HY-15030A

Naproxen sodium
Autophagy COX Inflammation/Immunology Cancer

Naproxen sodium is a COX-1 and COX-2 inhibitor with IC₅₀s of 8.72 and 5.15 μM, respectively in cell assay.

HY-109523

Cerivastatin sodium	HMG-CoA Reductase (HMGCR) Ferroptosis	Cancer Cardiovascular Disease
Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin sodium reduces low-density lipoprotein cholesterol levels. Cerivastatin sodium also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition, and has anti-cancer effect.

HY-108402A

Cefodizime sodium	Bacterial Antibiotic	Infection
Cefodizime sodium is a third generation cephalosporin antibiotic with a broad spectrum of antibacterial activity. Cefodizime sodium has no renal toxic effect, good tolerance and immune regulation activity, and has the potential for severe infections of the respiratory and urinary tracts.

HY-13569A

Beraprost sodium	Prostaglandin Receptor	Inflammation/Immunology Cardiovascular Disease
Beraprost sodium, a prostacyclin analog, is a stable and orally active prodrug of PGI2. Beraprost sodium is a potent vasodilator, has the potential for pulmonary arterial hypertension treatment through expanding renal vessels, improving microcirculation.

HY-Y0445A

Sodium dichloroacetate	PDHK Reactive Oxygen Species NKCC Apoptosis	Cancer
Sodium dichloroacetate is a metabolic regulator in cancer cells' mitochondria with anticancer activity. Sodium dichloroacetate inhibits PDHK, resulting in decreased lactic acid in the tumor microenvironment. Sodium dichloroacetate increases reactive oxygen species (ROS) generation and promotes cancer cell apoptosis. Sodium dichloroacetate also works as NKCC inhibitor.

HY-A0246A

Flucloxacillin sodium
Bacterial Antibiotic Infection

Flucloxacillin sodium is a highly active antibiotic against Gram-positive and Gram-negative bacteria.
HY-B0507A

Sulfathiazole sodium
Bacterial Antibiotic Infection

Sulfathiazole sodium is an organosulfur compound that has been used as a short-acting sulfa drug.

HY-N1404

Sodium aescinate	Others	Cancer Inflammation/Immunology
Sodium aescinate is a triterpene saponin derived from Aesculus hippocastanum seeds, with anti-inflammatory and antioxidant activities. Sodium aescinate inhibits hepatocellular carcinoma growth by targeting CARMA3/NF-κB pathway.

HY-B0135A

Furosemide sodium	NKCC	Cancer Metabolic Disease
Furosemide sodium is a loop diuretic inhibitor of Na+/2Cl-/K+ (NKCC) cotransporter of which used in the treatment of congestive heart failure and edema.

HY-B0466B

Cloxacillin sodium
Bacterial Antibiotic Infection Inflammation/Immunology

Cloxacillin sodium exhibits antibiotic efficacy, with a MIC of 256 mg/L for Staphylococcus aureus 25923.

HY-B0273A

Sulfadiazine sodium	Bacterial Parasite Antibiotic	Infection
Sulfadiazine sodium belongs to the class of sulfonamide antibiotics that are used for veterinary purposes worldwide, mainly in pig production. Sulfadiazine sodium is also used for toxoplasmosis.

HY-W009168

Tazobactam sodium	Bacterial Antibiotic	Infection
Tazobactam sodium is an antibiotic of the beta-lactamase inhibitor class. Ceftolozane combines with Tazobactam, extends the activity of ceftolozane against many ESBL-producing Enterobacteriaceae and some Bacteroides spp..

HY-100577

Ticarcillin sodium	Bacterial Antibiotic	Infection
Ticarcillin sodium is an injectable antibiotic for the treatment of Gram-negative bacteria, particularly Pseudomonas aeruginosa. It is also one of the few antibiotics capable of treating Stenotrophomonas maltophilia infections.

HY-115292

Simvastatin sodium	HMG-CoA Reductase (HMGCR)	Cancer
Simvastatin sodium is a lactone prodrug, can be hydrolysed to active hydroxy-acid by non-specific carboxyesterases or non-enzymatic processes. Simvastatin sodium shows a inhibition of HMG-CoA reductase with a K_i value of 0.12 nM.

HY-B0706A

Flomoxef sodium
Bacterial Infection

Flomoxef sodium is a oxacephem group antibiotic, with excellent activity against various Gram-positive bacteria.

HY-B1256

Cefuroxime sodium	Bacterial Antibiotic	Infection
Cefuroxime sodium is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime sodium has a broad spectrum activity against Gram-positive and Gram-negative bacteria.

HY-B1071A

Lasalocid sodium Lasalocid-A sodium; Ionophore X-537A sodium; Antibiotic X-537A sodium	Bacterial Autophagy Antibiotic	Cancer Infection
Lasalocid sodium (Lasalocid-A sodium) treatment led to an increase in cell wall thickness, whilst the quantity and sugar composition of the cell wall remained unchanged in BY-2 cells.

HY-17443B

*Sivelestat sodium* tetrahydrate** EI546 sodium tetrahydrate; LY544349 sodium tetrahydrate; ONO5046 sodium tetrahydrate	Elastase	Cancer
Sivelestat sodium tetrahydrate (EI546 sodium tetrahydrate) is a competitive inhibitor of human neutrophil elastase(IC50 = 44 nM; Ki=200 nM); also inhibited leukocyte elastase obtained from rabbit, rat, hamster and mouse.

HY-B0166A

*L-Ascorbic acid sodium* salt** (+)-sodium L-ascorbate; Vitamin C sodium salt; sodium L-ascorbate	Reactive Oxygen Species Apoptosis	Cancer
L-Ascorbic acid sodium salt is a more bioavailable form of vitamin C that is an antioxidant agent.

HY-19522A

*Seladelpar sodium* salt** MBX-8025 sodium salt; RWJ-800025 sodium salt	PPAR	Metabolic Disease
Seladelpar sodium salt (MBX-8025) is an orally active, potent and specific PPARδ agonist with an EC₅₀ of 2 nM, showing more than 750-fold and 2500-fold selectivity over the PPARα and PPARγ receptors, respectively.

HY-12326A

c-di-AMP sodium Cyclic diadenylate sodium; Cyclic-di-AMP sodium	STING Bacterial Endogenous Metabolite	Inflammation/Immunology
c-di-AMP (Cyclic diadenylate) sodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP sodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP sodium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses.

HY-B0167A

Sodium Salicylate Salicylic acid sodium salt; 2-Hydroxybenzoic acid sodium salt	COX Autophagy Apoptosis	Inflammation/Immunology Cancer
Sodium Salicylate (Salicylic acid sodium salt) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation.

HY-B1897A

Menadione bisulfite sodium Menadione sodium bisulfite; Vitamin K3 sodium bisulfite	Others
Menadione bisulfite (sodium) is used as an agent to induce acute oxidative stress, and to function as a plant-defense activator against several pathogens.

HY-17507B

*Pantoprazole sodium* hydrate** BY1023 sodium hydrate; SKF96022 sodium hydrate	Proton Pump Autophagy Apoptosis	Cancer
Pantoprazole sodium hydrate (BY1023 sodium hydrate; SKF96022 sodium hydrate) is a proton pump inhibitor drug used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.

HY-A0126A

Epoprostenol sodium Prostaglandin I2 sodium salt; Prostacyclin sodium salt; Flolan	Others	Cardiovascular Disease
Epoprostenol sodium (Prostaglandin I2 (sodium salt)), the synthetic form of the natural prostaglandin derivative prostacyclin (prostaglandin I2), is registered worldwide for the treatment of Pulmonary arterial hypertension (PAH). Epoprostenol sodium is used in pulmonary hypertension and transplantation as a potent inhibitor of platelet aggregation.

HY-107780A

Cyclic-di-GMP sodium c-di-GMP sodium; cyclic diguanylate sodium; 5GP-5GP sodium	STING Endogenous Metabolite	Cancer
Cyclic di-GMP sodium (c-di-GMP sodium) is a STING activator and a global bacterial second messenger, which regulates biofilm formation, motility, and virulence in diverse bacterial species.

HY-B1090S

Cinnarizine D8	Calcium Channel Histamine Receptor	Endocrinology Cardiovascular Disease
Cinnarizine D8 is a deuterium labeled Cinnarizine. Cinnarizine is an antihistamine and a calcium channel blocker.

HY-W040265

Fenamic acid
N-Phenylanthranilic acid
Chloride Channel Inflammation/Immunology

Fenamic acid is a chloride channel blocker^{[1]^.}

HY-B0612E

(S)-Lercanidipine hydrochloride	Calcium Channel	Cardiovascular Disease
(S)-Lercanidipine hydrochloride is the S-enantiomer of Lercanidipine hydrochloride. (S)-lercanidipine hydrochloride is a potent calcium channel blocker.

HY-12883A

PF-05198007	Sodium Channel	Neurological Disease
PF-05198007 is a potent, orally active and selective arylsulfonamide Na_v1.7 inhibitor. PF-05198007 is a compound with a similar pharmacodynamic profile to PF-05089771.

HY-16321

Micafungin sodium
FK 463 sodium
Fungal Antibiotic Infection

Micafungin sodium (FK 463 sodium) is an antifungal agent which inhibits 1, 3-beta-D-glucan synthesis.

HY-15298C

*Grazoprevir sodium* salt** MK-5172 (sodium salt)	HCV HCV Protease	Infection
Grazoprevir sodium salt (MK-5172 sodium salt) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with K_is of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively.

HY-14804A

Tasisulam sodium LY 573636 sodium	Apoptosis	Cancer
Tasisulam is a anticancer agent and induces apoptosis via the intrinsic pathway, resulting in cytochrome c release and caspase-dependent cell death. Tasisulam inhibits mitotic progression and induces vascular normalization.

HY-100775

*Setogepram sodium* salt** PBI-4050 sodium salt	GPR40 GPR84	Metabolic Disease Inflammation/Immunology
Setogepram sodium salt (PBI-4050 sodium salt) acts as an orally active agonist for GPR40 and as an antagonist or inverse agonist for GPR84. Setogepram sodium salt decreases renal, liver and pancreatic fibrosis. Setogepram sodium salt exerts anti-fibrotic, anti-inflammatory and anti-proliferative actions.

HY-B0522A

Ampicillin sodium D-(-)-α-Aminobenzylpenicillin sodium salt	Bacterial Antibiotic	Infection
Ampicillin sodium (D-(-)-α-Aminobenzylpenicillin sodium salt) is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria.

HY-120859A

*Zidebactam sodium* salt** WCK-5107 sodium salt	Bacterial	Infection
Zidebactam sodium salt (WCK-5107 sodium salt) is a potent β-lactamase inhibitor. Zidebactam also is a penicillin-binding protein2 (PBP2) inhibitor with an IC₅₀ of 0.26 μg/mL.

HY-B0448A

Phenytoin sodium 5,5-Diphenylhydantoin sodium salt	Sodium Channel Virus Protease	Neurological Disease
Phenytoin sodium (5,5-Diphenylhydantoin sodium salt) is an inactive voltage-gated sodium channel stabilizer.

HY-13564A

*Batimastat sodium* salt** BB-94 sodium salt	MMP	Cancer
Batimastat sodium salt is a potent broad spectrum MMP inhibitor with IC₅₀ of 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3, respectively.

HY-N0666C

L-Aspartic aicd sodium
sodium L-aspartate
Endogenous Metabolite Others

L-Aspartic aicd sodium is is an amino acid, shown to be a suitable prodrug for colon-specific drug deliverly.

HY-B0765

*Dehydroepiandrosterone sulfate sodium* salt** sodium prasterone sulfate	Endogenous Metabolite	Metabolic Disease
Dehydroepiandrosterone sulfate sodium salt (DHEAS) is the most abundant circulating steroid in human. Dehydroepiandrosterone sulfate sodium salt (DHEAS) affects steroid hormone biosynthesis on a molecular level resulting in an increased formation of pregnenolone.

HY-123672

Lovastatin hydroxy acid sodium Mevinolinic acid sodium	HMG-CoA Reductase (HMGCR)	Metabolic Disease
Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a K_i of 0.6 nM.

HY-136066

Tauro-ω-muricholic acid sodium TωMCA sodium	Others	Metabolic Disease
Tauro-ω-muricholic acid sodium (TωMCA sodium) is a bile acid released by the liver and an analog of tauro-α-muricholic acid. Tauro-ω-muricholic acid sodium is investigated as a potential marker in plasma for early-onset neonatal sepsis (EOS) and cholestasis studies

HY-130354

Dibutyryl-cGMP sodium Bt2cGMP sodium	Potassium Channel	Cardiovascular Disease
Dibutyryl-cGMP sodium (Bt2cGMP sodium) is a cell-permeable cGMP analogue. Dibutyryl-cGMP sodium preferentially activates cGMP-dependent protein kinase (PKG). Dibutyryl-cGMP sodium inhibits the release of [³H]-arachidonic acid from γ thrombin-stimulated human platelets. Dibutyryl-cGMP sodium induces peripheral antinociception via activation of ATP-sensitive K⁺ channels.

HY-B1463

Penicillin G sodium salt
Benzylpenicillin sodium salt
Bacterial Antibiotic Infection

Penicillin G sodium salt is a typical β-lactam antibiotic.

HY-B0977

*Dicloxacillin Sodium* hydrate** Dicloxacillin sodium salt monohydrate	Bacterial Antibiotic	Infection
Dicloxacillin Sodium hydrate (Dicloxacillin sodium salt monohydrate) is a narrow-spectrum β-Lactam antibiotic of the penicillin class, is used to treat infections caused by susceptible Gram-positive bacteria, active against beta-lactamase-producing organisms such as Staphylococcus aureus.

HY-50855B

*Silmitasertib sodium* salt** CX-4945 sodium salt	Casein Kinase Autophagy	Cancer
Silmitasertib sodium salt is an orally bioavailable, highly selective and potent CK2 inhibitor, with IC₅₀ values of 1 nM against CK2α and CK2α'.

HY-N0150

*Monensin sodium* salt** Monensin A sodium salt	Bacterial Sodium Channel Antibiotic	Infection Cancer
Monensin sodium salt is an antibiotic secreted by the bacteria Streptomyces cinnamonensis. Monensin sodium salt is an ionophore that mediates Na⁺/H⁺ exchange.

HY-B0597

Fondaparinux sodium
Fondaparin sodium; SR-90107A
Factor Xa Cardiovascular Disease

Fondaparinux sodium is an antithrombin-dependent factor Xa inhibitor.

HY-50202A

*Etomoxir sodium* salt** (R)-(+)-Etomoxir sodium salt	Apoptosis	Metabolic Disease Cancer
Etomoxir sodium salt ((R)-(+)-Etomoxir sodium salt) is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig.

HY-B1899A

*Taurodeoxychloic Acid sodium* hydrate** sodium taurodeoxycholate monohydrate	Caspase	Metabolic Disease Inflammation/Immunology
Taurodeoxychloic Acid sodium hydrate (Sodium taurodeoxycholate monohydrate) prevents apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxychloic Acid sodium hydrate is investigated for use in several conditions such as Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis, and Amyotrophic Lateral Sclerosis.

HY-B1439B

*Lorglumide sodium* salt** CR-1409 sodium salt	Cholecystokinin Receptor	Metabolic Disease Endocrinology
Lorglumide sodium salt (CR-1409 sodium salt) is a potent cholecystokinin (CCK) receptor antagonist.

HY-N1370

Tanshinone IIA sulfonate sodium sodium Tanshinone IIA sulfonate; Tanshinone IIA sodium sulfonate	CRAC Channel	Cardiovascular Disease Cancer
Tanshinone IIA sulfonate (sodium) is a derivative of tanshinone IIA, which acts as an inhibitor of store-operated Ca²⁺ entry (SOCE), and is used to treat cardiovascular disorders.

HY-14164A

Zileuton sodium A 64077 sodium; Abbott 64077 sodium	Lipoxygenase	Inflammation/Immunology
Zileuton sodium (A 64077 sodium) is a potent and selective inhibitor of 5-lipoxygenase, exhibiting inflammatory activities.

HY-B0124A

Zonisamide sodium AD 810 sodium; CI 912 sodium	Calcium Channel Sodium Channel	Neurological Disease
Zonisamide sodium is a 1,2 benzisoxazole derivative and the first agent of this chemical class to be developed as an antiepileptic drug.

HY-18569A

3-Indoleacetic acid sodium Indole-3-acetic acid sodium; 3-IAA sodium	Endogenous Metabolite	Metabolic Disease
3-Indoleacetic acid sodium (Indole-3-acetic acid sodium) is an endogenous metabolite.

HY-Y1173

*Isethionic acid sodium* salt** sodium 1-hydroxy-2-ethanesulfonate; sodium 2-hydroxy-1-ethanesulfonate; sodium 2-hydroxyethanesulfonate	Endogenous Metabolite	Metabolic Disease
Isethionic acid sodium salt is an endogenous metabolite.

HY-101918

DS-1040 Tosylate	Others	Cardiovascular Disease
DS-1040 Tosylate is an orally active, selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) with IC₅₀s of 5.92 nM and 8.01 nM for human and rat TAFIa. DS-1040 Tosylate is a fibrinolysis enhancer for thromboembolic diseases.

HY-18728

STF-31
GLUT Autophagy Cancer

STF-31 is a selective inhibitor of glucose transporter 1 (GLUT1), with an IC₅₀ of 1μM^[1][2].

HY-100628A

*Mafosfamide sodium* salt** Z 7557 sodium salt; cis-Mafosfamide sodium salt	DNA/RNA Synthesis DNA Alkylator/Crosslinker Apoptosis	Cancer
Mafosfamide sodium salt (Z 7557 sodium salt) targets nuclear DNA, forms DNA cross-links and inhibits DNA synthesis. Mafosfamide sodium salt, a cyclophosphamide analogue, induces apoptosis in lymphoblastoid cells. Mafosfamide sodium salt has antitumor activity.

HY-B1131

*Taurocholic acid sodium* salt hydrate** sodium taurocholate hydrate; N-Choloyltaurine sodium salt hydrate	Endogenous Metabolite	Inflammation/Immunology
Taurocholic acid sodium salt hydrate (Sodium taurocholate hydrate) is a bile acid involved in the emulsification of fats.

HY-D0858B

*MES sodium* salt** 2-Morpholinoethanesulphonic acid sodium salt	Others	Others
MES (2-Morpholinoethanesulphonic acid) sodium salt, a zwitterionic buffer, is effective in the pH range of 5.5-7.7. MES sodium salt, as one of the Good’s buffers, is broadly used to regulate pH value for plants culture medium, reagent solution, and physiological experiments.

HY-19989A

*MK-571 sodium* salt** L-660711 sodium salt	Leukotriene Receptor	Inflammation/Immunology
MK-571 sodium salt is a selective, orally active leukotriene D4 receptor antagonist, with K_is of 0.22 and 2.1 nM in guinea pig and human lung membranes.

HY-135748

Polyinosinic-polycytidylic acid sodium Poly(I:C) sodium	Toll-like Receptor (TLR) Apoptosis	Cancer Inflammation/Immunology
Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid sodium can directly trigger cancer cells to undergo apoptosis.

HY-N1429

*Taurochenodeoxycholic acid sodium* salt** 12-Deoxycholyltaurine sodium salt	Apoptosis Endogenous Metabolite	Inflammation/Immunology
Taurochenodeoxycholic acid sodium salt (12-Deoxycholyltaurine sodium salt) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid induces apoptosis and shows obvious anti-inflammatory and immune regulation properties.

HY-112847A

Sulfosuccinimidyl oleate sodium Sulfo-N-succinimidyl oleate sodium	Mitophagy	Inflammation/Immunology
Sulfosuccinimidyl oleate sodium (Sulfo-N-succinimidyl oleate sodium) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate sodium is a potent and irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate sodium binds the CD36 receptor on the surface of microglia. Anti-inflammatory effect.

HY-W013636A

2-Ketoglutaric acid Sodium Alpha-Ketoglutaric acid sodium	Tyrosinase Endogenous Metabolite	Metabolic Disease
2-Ketoglutaric acid Sodium (Alpha-Ketoglutaric acid Sodium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid Sodium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid Sodium is a reversible inhibitor of tyrosinase (IC₅₀=15 mM).

HY-18341A

*L-Thyroxine sodium* salt pentahydrate** sodium levothyroxine pentahydrate	Thyroid Hormone Receptor	Endocrinology
L-Thyroxine sodium salt pentahydrate (Levothyroxine; T4) is a synthetic hormone in the treatment of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).

HY-B1350A

Fusidic acid sodium salt
sodium fusidate; SQ-16360
Bacterial Antibiotic Infection

Fusidic acid sodium salt is a bacteriostatic antibiotic.

HY-135103

Tauro-β-muricholic acid sodium T-βMCA sodium	FXR	Cancer
Tauro-β-muricholic Acid sodium (T-βMCA sodium), a endogenous metabolite, is a competitive and reversible farnesoid X receptor (FXR) antagonist, with an IC₅₀ of 40 μM.

HY-A0272

Sodium laureth sulfate sodium lauryl polyoxyethylene ether sulfate	Others	Others
Sodium lauryl polyoxyethylene ether sulfate is an anionic surfactant, with excellent decontamination, emulsification, dispersion, wetting, solubilizing performance and foaming property.

HY-129655

Sulfo-SMPB sodium	ADC Linker	Cancer
Sulfo-SMPB sodium is a non-cleavable, heterobifunctional chemical cross-linking reagent which contains N-hydroxysuccinimide (NHS) ester and maleimide groups, allowing covalent conjugation of amine- and sulfhydryl-containing molecules.

HY-B1282A

*Sulfaquinoxaline sodium* salt**	Bacterial Parasite Antibiotic	Infection
Sulfaquinoxaline sodium salt is an antimicrobial for veterinary use, with activity against a broad spectrum of Gram-negative and Gram-positive bacteria. Sulfaquinoxaline is used to prevent coccidiosis and bacterial infections.

HY-101364A

*CHPG sodium* salt**	mGluR NF-κB ERK Akt	Inflammation/Immunology Neurological Disease
CHPG sodium salt is a selective mGluR5 agonist, and attenuates SO₂-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. CHPG sodium salt protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways..

HY-111355B

Cholesteryl sulfate sodium
Endogenous Metabolite Metabolic Disease

Cholesteryl sulfate sodium is an endogenous metabolite.

HY-15286

Sodium 4-pentynoate	Others	Others
Sodium 4-pentynoate is a alkynylacetate analogue; can be metabolically incorporated onto cellular proteins through biosynthetic mechanisms for profiling of acetylated proteins in diverse cell types.

HY-B0465

Oxacillin sodium monohydrate
Bacterial Antibiotic Infection

Oxacillin sodium monohydrate is an antibiotic similar to flucloxacillin used in resistant staphylococci infections.
HY-100447

TM5275 sodium
PAI-1 Cancer Cardiovascular Disease

TM5275 sodium is a plasminogen activator inhibitor (PAI-1) with an IC₅₀ of 6.95 μM.
HY-17479A

Amfenac Sodium Hydrate
COX Inflammation/Immunology

Amfenac Sodium Hydrate is a COX-2 inhibitor.
HY-B1279

Metamizole sodium hydrate
COX Inflammation/Immunology

Metamizole sodium hydrate is a potent analgesic drug that has been demonstrated to inhibit cyclooxygenase (COX).

HY-14280A

*Entacapone sodium* salt**	COMT	Neurological Disease
Entacapone is a specific, potent, peripherally acting catechol-O-methyltransferase (COMT) inhibitor with IC50 of 151 nM for PD treatment.

HY-D0859A

MOPS sodium salt
Others Others

MOPS sodium salt is commonly used as a buffering agent in biology. MOPS buffer can maintain the pH of mammalian cell culture media.

HY-135034

UMB68 sodium	Others	Neurological Disease
UMB68 sodium is a selective GHB receptor ligand. UMB68 sodium displaces [³H]NCS-382 with an IC₅₀ of 38 nM in rat cerebrocortical membranes. UMB68 sodium has no significant affinity at GABAB receptors, cannot be metabolized to GABA-active compounds.

HY-A0203A

Pentosan Polysulfate Sodium	HIV	Infection Inflammation/Immunology
Pentosan Polysulfate Sodium is an orally bioavailable, semi-synthetic medication with anti-inflammatory and pro-chondrogenic properties. Pentosan Polysulfate Sodium also is a potent and selective anti-HIV agent. Pentosan Polysulfate Sodium is used for the treatment of interstitial cystitis.

HY-90003A

Tianeptine sodium salt
5-HT Receptor Neurological Disease

Tianeptine sodium salt is a selective facilitator of 5-HT uptake in vitro and in vivo.

HY-125108

PHPS1 sodium	Phosphatase	Cancer Cardiovascular Disease
PHPS1 sodium is a potent and selective Shp2 inhibitor with K_is of 0.73, 5.8, 10.7, 5.8, and 0.47 μM for Shp2, Shp2-R362K, Shp1, PTP1B, and PTP1B-Q, respectively.

HY-100381

*Nigericin sodium* salt**	Potassium Channel NOD-like Receptor (NLR) Bacterial Antibiotic	Cancer Infection
Nigericin sodium salt is an antibiotic from Streptomyces hygroscopicus that works by acting as an H⁺, K⁺, and Pb²⁺ ionophore, a NLRP3 activator.

HY-13627

Estramustine phosphate sodium	Microtubule/Tubulin	Cancer
Estramustine phosphate sodium is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the G2/M phase of the cell cycle.

HY-N0324A

Cholic acid sodium	Endogenous Metabolite	Metabolic Disease
Cholic acid sodium is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.

HY-U00087

*Tosylchloramide sodium* trihydrate**	Bacterial	Infection
Tosylchloramide sodium trihydrate (Chloramine T sodium trihydrate) is a disinfectant agent widely used in laboratories, kitchens and hospitals. It is also used as a biocide in air fresheners and deodorants.

HY-B0555A

Nafcillin sodium monohydrate
Bacterial Antibiotic Infection

Nafcillin sodium monohydrate is a semi-synthetic antibiotic related to penicillin.
HY-B0925

Oxacillin sodium salt
Bacterial Antibiotic Infection

Oxacillin sodium salt is a narrow-spectrum β-lactam antibiotic of the penicillin class.

HY-107789

Sodium lauryl sulfoacetate	Others	Inflammation/Immunology
Sodium lauryl sulfoacetate is a solid anionic surfactant of vegetable origin. Sodium lauryl sulfoacetate is an immunoadjuvant. Anti-immunosuppressive effect.

HY-B0466

*Cloxacillin sodium* monohydrate**	Bacterial Antibiotic	Infection Inflammation/Immunology
Cloxacillin sodium monohydrate exhibits antibiotic efficacy, with a MIC of 256 mg/L for Staphylococcus aureus 25923.

HY-112502B

MethADP sodium salt
CD73 Cancer

MethADP (sodium salt) is a specific CD73 inhibitor.
HY-128740

Mesoxalate sodium (monohydrate)
Endogenous Metabolite Metabolic Disease

Mesoxalate sodium monohydrate is an endogenous metabolite.

HY-136615

5-Hydroxydecanoate sodium	Potassium Channel	Neurological Disease
5-Hydroxydecanoate sodium is a selective ATP-sensitive K⁺ (K_ATP) channel blocker (IC₅₀ of ~30 μM). 5-Hydroxydecanoate sodium is a substrate for mitochondrial outer membrane acyl-CoA synthetase and has antioxidant activity.

HY-107512

Kynurenic acid sodium	iGluR Apoptosis	Inflammation/Immunology Neurological Disease Endocrinology
Kynurenic acid sodium, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid sodium is also an agonist of GPR35/CXCR8.

HY-W012790

Sodium 2-hydroxybutanoate
Endogenous Metabolite Metabolic Disease

Sodium 2-hydroxybutanoate is an endogenous metabolite.

HY-B0888

*Sulfacetamide sodium* monohydrate**	Bacterial Antibiotic	Infection
Sulfacetamide sodium monohydrate is a sulfonamide antibiotic, has been investigated for use in the treatment of pityriasis versicolor and rosacea.

HY-B1489

Tolmetin sodium dihydrate
COX Inflammation/Immunology

Tolmetin sodium dihydrate is a non-steroidal antiinflammatory agent, and acts as a non-selective COX inhibitor.

HY-N7114A

Chloramphenicol succinate sodium	Bacterial Antibiotic	Metabolic Disease Infection
Chloramphenicol succinate sodium is a prodrug of Chloramphenicol, with Haemotoxicity. Chloramphenicol succinate is a competitive substrate and inhibitor of succinate dehydrogenase (SDH) that is the possible reason for its toxicity.

HY-129525A

Sulfo-SIAB sodium
ADC Linker Cancer

Sulfo-SIAB sodium is a nonclaevable monovalent bilinker.

HY-128853

*Taurodeoxycholate sodium* salt**	Endogenous Metabolite	Inflammation/Immunology
Taurodeoxycholate sodium salt is a bile salt-related anionic detergent used for isolation of membrane proteins including inner mitochondrial membrane proteins. Taurodeoxycholate (TDCA) inhibits various inflammatory responses .

HY-D0975

Sulfo-SMCC sodium	ADC Linker	Cancer
Sulfo-SMCC sodium is a commonly used hetero-bifunctional, noncleavable ADC crosslinker bearing N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups, respectively.

HY-100791

NSC23005 sodium	Others	Cancer
NSC23005 sodium is a novel and effective p18 inhibitor (ED₅₀=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models.

HY-14417B

VU0155041 sodium	mGluR	Neurological Disease
VU0155041 sodium is a potent, selective and mixed allosteric agonist/positive allosteric modulator (PAM) of mGluR4, with EC₅₀s of 798 nM and 693 nM for human and rat mGluR4, respectively. VU0155041 sodium is a partial agonist of mGluR4 that activates the receptor by interacting with a site that is distinct from the glutamate binding site.

HY-W002213

N-Hydroxysulfosuccinimide sodium
ADC Linker Cancer

N-Hydroxysulfosuccinimide (sodium) is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-100619A

BMS-986020 sodium	LPL Receptor	Metabolic Disease Inflammation/Immunology
BMS-986020 sodium is a high-affinity lysophosphatidic acid receptor 1 (LPA1) antagonist. BMS-986020 sodium inhibits bile acid and phospholipid transporters with IC₅₀s of 4.8 µM, 6.2 µM, and 7.5 µM for BSEP, MRP4, and MDR3, respectively. BMS-986020 sodium has the potential for the treatment of idiopathic pulmonary fibrosis (IPF).

HY-101905

Moniliformin sodium salt
Fungal Antibiotic Infection

Moniliformin sodium salt is a potent, water-soluble mycotoxin isolate from Fusarium moniliforme.

HY-B1060

*6α-Methylprednisolone 21-hemisuccinate sodium* salt** Methylprednisolone sodium succinate; 6-Methylprednisolone succinate sodium	Others	Inflammation/Immunology
6α-Methylprednisolone 21-hemisuccinate sodium salt is a glucocorticoid of slightly longer half-life than that of Prednisolone.

HY-135407S

N-Desethyl Oxybutynin D5 hydrochloride	Drug Metabolite	Neurological Disease
N-Desethyl Oxybutynin D5 hydrochloride is deuterium labeled N-Desethyl Oxybutynin hydrochloride. N-Desethyl Oxybutynin is the the active metabolite Oxybutynin. Oxybutynin is an anticholinergic agent that inhibits voltage-dependent K⁺ channels.

HY-117825

RU-TRAAK-2	Potassium Channel	Neurological Disease
RU-TRAAK-2 is a completely reversible TRAAK (TWIK-related arachidonic acid-stimulated K⁺ channel) inhibitor. RU-TRAAK-2 exerts no activity for non-K2P channels (Kv1.2, Slo1 and GIRK2).

HY-135013

Umbellulone	TRP Channel	Neurological Disease
Umbellulone is an active constituent of the leaves of Umbellularia californica. Umbellulone stimulates the TRPA1 channel in a subset of peptidergic, nociceptive neurons, activating the trigeminovascular system via this mechanism.

HY-15583

Auristatin F	Microtubule/Tubulin ADC Cytotoxin	Cancer
Auristatin F is a potent cytotoxin. Auristatin F, a potent microtubule inhibitor and vascular damaging agent (VDA), can be used in antibody-drug conjugates (ADC).

HY-N2877

Annonacin	Potassium Channel Sodium Channel Na+/K+ ATPase Calcium Channel	Neurological Disease
Annonacin is an Acetogenin and promotes cytotoxicity via a pathway inhibiting the mitochondrial complex. Annonacin is the active agent found in Graviola leaf extract to act as an inhibitor of sodium/potassium (NKA) and sarcoplasmic reticulum (SERCA) ATPase pumps.

HY-108415

*Cloprostenol sodium* salt** ICI 80996 sodium salt	Prostaglandin Receptor	Endocrinology
Cloprostenol sodium salt (ICI 80996 sodium salt) is a potent synthetic prostaglandin analogue, acts as a luteolytic agent, and is a PGF2α receptor agonist.

HY-B0091A

*Adapalene sodium* salt** CD 271 sodium salt	RAR/RXR Autophagy	Inflammation/Immunology
Adapalene sodium salt(CD 271; Differin), a synthetic retinoid, is a Retinoic acid receptor agonist (RAR).

HY-100811A

*7-Chlorokynurenic acid sodium* salt** 7-CKA sodium salt	iGluR	Neurological Disease
7-Chlorokynurenic acid sodium salt (7-CKA sodium salt) is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor (IC₅₀=0.56 μM). 7-Chlorokynurenic acid sodium salt is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a K_i of 0.59 μM. 7-Chlorokynurenic acid sodium salt has potent antinociceptive actions after neuraxial delivery.

HY-111815A

N4-Acetylcytidine triphosphate sodium ac4CTP sodium	Endogenous Metabolite	Others
N4-Acetylcytidine triphosphate sodium is efficiently used as a substrate in T7 Polymerase-catalyzed in vitro transcription and can be incorporated into multiple templates.

HY-18572A

*2,4-D sodium* salt** sodium 2,4-dichlorophenoxyacetate; 2,4-Dichlorophenoxyacetic acid sodium salt	DNA/RNA Synthesis	Others
2,4-D sodium salt (Sodium 2,4-dichlorophenoxyacetate) is a selective systemic herbicide for the control of broad-leaved weeds. 2,4-D sodium salt acts as a plant hormone, causing uncontrolled growth in the meristematic tissues. 2,4-D sodium salt inhibits DNA and protein synthesis and thereby prevents normal plant growth and development.

HY-N2581

*Phytic acid sodium* salt** myo-Inositol, hexakis(dihydrogen phosphate) sodium salt; Inositol hexaphosphate sodium salt	Others	Others
Phytic acid sodium salt (myo-Inositol; hexakis dihydrogen phosphate; Inositol hexaphosphat) is often present in legume seeds with antinutritional effects. Phytic acid sodium salt is a [PO4]³- storage depot and precursor for other inositol phosphates and pyrophosphates. phytic acid is hydrolyzed by phytases in a stepwise manner in the plant.

HY-B0964

Riboflavin phosphate sodium FMN-Na; Riboflavin 5'-phosphate sodium; Vitamin B2 Phosphate sodium Salt	Endogenous Metabolite	Others
Riboflavin phosphate sodium significantly increases in corneal biomechanical stiffness

HY-17567C

*Heparin sodium* salt (MW 15kDa)** sodium heparin (MW 15kDa); sodium heparinate (MW 15kDa)	Thrombin Factor Xa Autophagy	Cardiovascular Disease
Heparin sodium salt (MW 15kDa) (Sodium heparin (MW 15kDa)) is a polymer of Heparin with the molecular weight of 15kDa. Heparin sodium salt is an anticoagulant which binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin factor IIa and factor Xa.

HY-A0119

Nitroprusside disodium dihydrate sodium nitroprusside dihydrate; sodium Nitroferricyanide(III) Dihydrate	Autophagy	Cardiovascular Disease Cancer
Nitroprusside disodium dihydrate is a potent vasodilator working through releasing NO spontaneously in blood.

HY-I0447A

Sodium 4-aminosalicylate dihydrate 4-Aminosalicylic acid sodium salt dihydrate	Bacterial Antibiotic	Infection
Sodium 4-aminosalicylate dihydrate (4-Aminosalicylic acid sodium salt dihydrate) is one of the antimycobacterial drugs currently used for multidrug-resistant tuberculosis.

HY-100564A

2',3'-cGAMP sodium 2'-3'-cyclic GMP-AMP sodium	Endogenous Metabolite STING IFNAR	Metabolic Disease
2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP sodium binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP sodium is produced in mammalian cells in response to DNA in the cytoplasm.

HY-12306

*8-Bromo-cAMP sodium* salt** 8-Br-Camp sodium salt	PKA	Cancer
8-Bromo-cAMP sodium salt (8-Br-Camp sodium salt), a cyclic AMP analog, is an activator of cyclic AMP-dependent protein kinase (PKA).

HY-17504BS

Rosuvastatin D3 Sodium	HMG-CoA Reductase (HMGCR) Autophagy	Metabolic Disease Cardiovascular Disease
Rosuvastatin D3 Sodium is deuterium labeled Rosuvastatin, which is a competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM.

HY-101203A

GJ103 sodium salt
Others Others

GJ103 sodium salt is an active analog of the read-through compound GJ072.

HY-B0398A

*Nalidixic acid sodium* salt**	Bacterial Antibiotic Topoisomerase	Infection
Nalidixic acid sodium salt, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria.

HY-B0911

Sodium copper chlorophyllin A	Others	Cancer
Sodium copper chlorophyllin A is a semi-synthetic mixture of water-soluble sodium copper salts derived from chlorophyll, primarily used as a food additive and in alternative medicine.

HY-B0382

Fosinopril sodium SQ28555	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Fosinopril Sodium is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.

HY-B2226

Sodium copper chlorophyllin B	HIV Influenza Virus	Infection
Sodium copper chlorophyllin B exerts antiviral activities against Influenza virus and HIV with IC₅₀s of 50 to 100 μM for both of them.

HY-14879A

Avibactam sodium NXL-104	Bacterial Antibiotic	Infection
Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC₅₀s of 8 nM and 5 nM, respectively.

HY-A0214

*Colistin methanesulfonate sodium* salt**	Bacterial	Infection
Colistin methanesulfonate sodium salt exhibits MIC values ranged from 4 to 16 mg/liter against susceptible strains (P. aeruginosa).

HY-B0425A

Novobiocin Sodium Albamycin; Cathomycin	Bacterial Autophagy Antibiotic	Infection Cancer
Novobiocin Sodium (Albamycin; Cathomycin) is an orally active antibiotic compound derived from Streptomyces niveus and a potent DNA gyrase inhibitor by binding the ATP-binding site in the ATPase subunit. Novobiocin Sodium manifests strong anti-bacterial activities effectively against gram-positive pathogens and shows limited activity against gram-negative organisms due to LPS-containing outer membrane.Novobiocin Sodium binds to the C-terminus of Hsp90 and slightly induces degradation of Hsp90-dependent client proteins (IC₅₀=700 µM).

HY-13244

Disufenton sodium NXY-059	Reactive Oxygen Species	Neurological Disease
Disufenton sodium (NXY-059) is the disulfonyl derivative of the neuroprotective spin trap phenylbutynitrone(PBN), both NXY-059, its parent PBN and their hydrolysis/oxidation product MNT are very powerful scavengers of free radicals.

HY-B0525A

Carbenicillin disodium sodium carbenicillin	Bacterial Antibiotic	Infection
Carbenicillin disodium is a beta-lactam penicillin derivative that interference with final stage of bacterial cell wall synthesis.

HY-N7517

Adenosine 5′-monophosphoramidate sodium	Nucleoside Antimetabolite/Analog	Others
Adenosine 5′-monophosphoramidate sodium is an adenosine derivative and can be used as an intermediate for nucleotide synthesis. Adenosine 5′-monophosphoramidate has a significant effect on the accumulation of cyclic AMP.

HY-135791

T-705RTP sodium	DNA/RNA Synthesis Influenza Virus SARS-CoV	Infection
T-705RTP sodium is a selective and GTP-competitive influenza virus RNA polymerase inhibitor with an IC₅₀ of 0.14 μM and a K_i of 1.52 μM. T-705RTP sodium is the active triphosphate metabolite of T-705 and has potent anti-influenza virus activity.

HY-B0079

Sugammadex sodium
Org25969
Others Neurological Disease

Sugammadex sodium is a synthetic γ-cyclodextrin derivative, and acts as a new reversal agent for neuromuscular block.

HY-15600B

*UPF-648 sodium* salt**	Others	Neurological Disease
UPF-648 sodium salt is a potent kynurenine 3-monooxygenase (KMO) inhibitor; exhibits highly active at 1 uM (81 ± 10% KMO inhibition); ineffective at blocking KAT activity.

HY-17504BS1

Rosuvastatin D6 Sodium	HMG-CoA Reductase (HMGCR) Autophagy	Metabolic Disease Cardiovascular Disease
Rosuvastatin D6 Sodium is deuterium labeled Rosuvastatin, which is a competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM.

HY-128932

Cefminox sodium MT-141	Bacterial PPAR Prostaglandin Receptor Antibiotic	Infection Cardiovascular Disease Endocrinology
Cefminox sodium (MT-141) is a semisynthetic cephamycin, which exhibits a broad spectrum of antibacterial activity. Cefminox sodium (MT-141) also acts as a dual agonist of prostacyclin receptor (IP) and PPARγ, upregulates cAMP production and PTEN expression and inhibits Akt/mTOR signaling. Cefminox sodium (MT-141) also prevents pulmonary arterial hypertension.

HY-112540B

*Acetoacetic acid sodium* salt**	Others	Metabolic Disease
Acetoacetic acid sodium salt is a metabolite of non-esterified fatty acids, involved in the development of human diabetes. Acetoacetic acid sodium salt induces oxidative stress to inhibit the assembly of very low density lipoprotein in bovine hepatocytes.

HY-B1117

Cefoxitin sodium MK-306	Bacterial Antibiotic	Infection Cancer
Cefoxitin sodium (MK-306) is a cephamycin antibiotic, often grouped with the second generation cephalosporins, acts by interfering with cell wall synthesis, its activity spectrum includes a broad range of gram-negative and gram-positive bacteria.

HY-13315

Montelukast sodium
MK0476
Leukotriene Receptor Autophagy Inflammation/Immunology Cancer

Montelukast (sodium) (MK0476) is a potent, selective CysLT₁ receptor antagonist.
HY-10414

MK-2894 sodium salt
Prostaglandin Receptor Inflammation/Immunology Endocrinology

MK-2894 sodium salt is a highly potent and selective second generation EP4 antagonist.

HY-U00027

Quinotolast sodium FR71021	Histamine Receptor Leukotriene Receptor Prostaglandin Receptor	Inflammation/Immunology Endocrinology
Quinotolast sodium in the concentration range of 1-100 μg/mL inhibits histamine, LTC₄ and PGD₂ release in a concentration-dependent manner.

HY-15894

*BQ-788 sodium* salt**	Endothelin Receptor	Cardiovascular Disease Endocrinology Cancer
BQ-788 sodium salt is a potent and selective ETB receptor antagonist, inhibiting ET-1 binding to ETB receptors with an IC₅₀ of 1.2 nM in human Girrardi heart cells.

HY-B1596A

Ceftizoxime sodium SKF-88373	Bacterial Antibiotic	Infection
Ceftizoxime sodium (SKF-88373) is third generation cephalosporin effective against Gram-negative and Gram-positive bacteria. It binds penicillin-binding proteins (PBPs) and inhibits the bacterial cell wall synthesis.

HY-101379A

8-Bromo-cGMP sodium	Calcium Channel	Neurological Disease
8-Bromo-cGMP sodium, a membrane-permeable analogue of cGMP, is a PKG (protein kinase G) activator and significantly inhibits Ca²⁺ macroscopic currents and impairs insulin release stimulated with high K⁺. 8-Bromo-cGMP sodium has antinociceptive effects.

HY-16504

Treprostinil sodium UT-15	Prostaglandin Receptor	Inflammation/Immunology Endocrinology
Treprostinil sodium is a potent DP1 and EP2 agonist with EC₅₀ values of 0.6±0.1 and 6.2±1.2 nM, respectively.

HY-B0691A

Ecabet sodium TA-2711	Reactive Oxygen Species Bacterial	Infection
Ecabet sodium (TA-2711) is currently applied to some gastrointestinal disease by inhibiting the ROS production and improving Helicobacter pylori eradication. Ecabet sodium reduces apoptosis.

HY-113377A

L-Glyceric acid sodium	Endogenous Metabolite	Metabolic Disease
L-Glyceric acid sodium is a mainly urinary metabolite accumulating in rare inherited metabolic disease L-glyceric aciduria. L-Glyceric acid sodium can be used to diagnose primary hyperoxaluria type 2 (PH2). L-Glyceric acid sodium excretion to distinguish PH1 from PH2.

HY-122470

Stampidine	Reverse Transcriptase HIV	Infection
Stampidine is a nucleoside reverse transcriptase inhibitor (NRTI) with potent and broad-spectrum anti-HIV activity. Stampidine inhibits the laboratory HIV-1 strain HTLV_IIIB (B-envelope subtype) and primary clinical isolates with IC₅₀s of 1 nM and 2 nM, respectively. Stampidine also inhibits NRTI-resistant primary clinical isolates and NNRTI-resistant clinical isolates with IC₅₀s of 8.7 nM and 11.2 nM, respectively.

HY-P0189

ω-Conotoxin GVIA
Calcium Channel Neurological Disease

ω-Conotoxin GVIA is an inhibitor of the N-type Ca²⁺ channel.

HY-110325

PF-04885614	Sodium Channel	Neurological Disease
PF-04885614 is a potent NaV1.8 inhibitor, extracted from patent US2018328915. PF-04885614 has potential for neurological and neurodevelopmental diseases treatment.

HY-103310

MRS1845
Calcium Channel CRAC Channel Cardiovascular Disease

MRS1845 is a selective store-operated calcium (SOC) channel inhibitor with an IC₅₀ of 1.7 μM. MRS1845 is an ORAI1 inhibitor.

HY-101436A

Sematilide hydrochloride CK-1752 hydrochloride	Potassium Channel	Cardiovascular Disease
Sematilide hydrochloride (CK-1752 hydrochloride) is a selective I_Kr channel blocker. Sematilide causes a concentration-dependent inhibition of the delayed rectifier K⁺ current (IC₅₀=25 μM). Sematilide is a class III antiarrhythmic agent.

HY-B1546

Benzamil Benzylamiloride	Sodium Channel Na+/Ca2+ Exchanger	Neurological Disease
Benzamil (Benzylamiloride), an Amiloride analogue, is a Na⁺/Ca²⁺ exchanger (NCX) inhibitor (IC₅₀~100 nM). Benzamil also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil inhibits TRPP3-mediated Ca²⁺-activated currents, with an IC₅₀ of 1.1 μM.

HY-101436

Sematilide CK-1752	Potassium Channel	Cardiovascular Disease
Sematilide (CK-1752) is a selective I_Kr channel blocker. Sematilide causes a concentration-dependent inhibition of the delayed rectifier K⁺ current (IC₅₀=25 μM). Sematilide is a class III antiarrhythmic agent.

HY-B1546A

Benzamil hydrochloride Benzylamiloride hydrochloride	Na+/Ca2+ Exchanger Sodium Channel	Neurological Disease
Benzamil hydrochloride (Benzylamiloride hydrochloride), an Amiloride analogue, is a Na⁺/Ca²⁺ exchanger (NCX) inhibitor (IC₅₀~100 nM). Benzamil hydrochloride also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil hydrochloride inhibits TRPP3-mediated Ca²⁺-activated currents, with an IC₅₀ of 1.1 μM.

HY-P0189A

ω-Conotoxin GVIA TFA
Calcium Channel Neurological Disease

ω-Conotoxin GVIA TFA is an inhibitor of the N-type Ca²⁺ channel.

HY-D0850

Tartaric acid disodium dihydrate sodium tartrate dibasic dihydrate; sodium tartrate dihydrate	Phosphatase	Cancer
Tartaric acid disodium dihydrate is a Acid phosphatase inhibitor, is a sodium salt used in buffers for molecular biology and cell culture applications.

HY-112942A

*CMP-Sialic acid sodium* salt** CMP-Neu5Ac sodium salt	Others	Metabolic Disease
CMP-Sialic acid sodium salt (CMP-Neu5Ac sodium salt) is an allosteric inhibitor of UDP-GlcNAc 2-epimerase, the enzyme that initiates sialic acid synthesis. CMP-Sialic acid sodium salt provides a substrate for Golgi sialyltransferases.

HY-B0231BS

*Enalaprilat D5 Sodium* Salt** MK-422 D5 sodium Salt	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Enalaprilat D5 Sodium Salt is the deuterium labeled Enalaprilat(MK-422), which is an angiotensin-converting enzyme (ACE) inhibitor.

HY-B1500

2,2,2-Trichloroethanol	Potassium Channel	Neurological Disease
2,2,2-Trichloroethanol, the active form of the sedative hypnotic drug chloral hydrate, is an agonist for the nonclassical K_2P channels TREK-1 (KCNK2) and TRAAK (KCNK4).

HY-11007

GNF-2
Bcr-Abl SARS-CoV Cancer

GNF-2 is a highly selective, allosteric, non-ATP competitive inhibitor of Bcr-Abl. GNF-2 inhibits Ba/F3.p210 proliferation with an IC₅₀ of 138 nM .

HY-100595

Sodium stibogluconate Stibogluconate trisodium nonahydrate	Phosphatase	Cancer
Sodium stibogluconate (Stibogluconate trisodium nonahydrate) is a potent inhibitor of protein tyrosine phosphatase. Sodium stibogluconate inhibits 99% of SHP-1, SHP-2 and PTP1B activity at 10, 100, 100 μg/mL, respectively.

HY-112853

*Fosmidomycin sodium* salt** FR-31564	Bacterial Antibiotic	Infection
Fosmidomycin sodium salt is a phosphonic acid antibiotic and a antimalarial drug, which is active against both Gram-negative and Gram-positive bacteria.

HY-B1166

Cefamandole nafate Cefamandole formate sodium	Bacterial Antibiotic	Infection
Cefamandole nafate (Cefamandole formate sodium) is a second-generation broad-spectrum cephalosporin antibiotic.

HY-106080A

Furegrelate sodium U-63557A	Others	Cardiovascular Disease
Furegrelate Sodium (U-63557A) is a potent, orally available, and selective thromboxane synthase inhibitor. Furegrelate Sodium inhibits human platelet microsomal thromboxane A2 (TxA2) synthase with an IC₅₀ of 15 nM. Furegrelate Sodium is being developed as an antiplatelet agent.

HY-111095B

(2R)-2-Hydroxypropanoate sodium
Endogenous Metabolite Metabolic Disease

(2R)-2-Hydroxypropanoate sodium is an endogenous metabolite.

HY-10432A

*A 83-01 sodium* salt**	TGF-β Receptor ALK	Cancer
A 83-01 sodium salt is a potent inhibitor of TGF-β type I receptor ALK5 kinase, ALK4 and ALK7, with IC₅₀s of 12 nM, 45 nM and 7.5 nM against the transcription induced by ALK5, ALK4 and ALK7, respectively.

HY-13679

Mesna sodium 2-mercaptoethanesulfonate; Mesnum	Others	Cancer
Mesna, is a synthetic small molecule, widely used as a systemic protective agent against chemotherapy toxicity, but is primarily used to reduce hemorrhagic cystitis induced by cyclophosphamide.

HY-17474A

Parecoxib Sodium
SC 69124A
COX Inflammation/Immunology Cancer

Parecoxib Sodium (SC 69124A) is a potent and selective COX-2 inhibitor.

HY-114456B

*Ganglioside GM3 sodium* salt**	Others	Cancer Metabolic Disease
Ganglioside GM3 sodium salt is a sialylated membrane-based glycosphingolipid that regulates insulin receptor signaling via direct association with the receptor. Ganglioside GM3 sodium salt possesses powerful effects on cancer development and progression.

HY-D0799

Sulfo-NHS-LC-Biotin sodium
Others Others

Sulfo-NHS-LC-Biotin sodium is a water soluble amine-reactive biotinylation reagent that can be used for antibody labeling.

HY-101109

Sodium ionophore III ETH2120	Sodium Channel	Cardiovascular Disease
Sodium ionophore III (ETH2120) is a Na⁺ ionophore suitable for the assay of sodium activity in blood, plasma, serum. etc.

HY-W010791

*Adenosine 5'-diphosphate sodium* salt**	Endogenous Metabolite	Others
Adenosine 5'-diphosphate (ADP) sodium salt is a nucleoside diphosphate, which is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate sodium salt induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P_2T-purinoceptors.

HY-14664A

Fluvastatin sodium XU 62-320	HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis	Cardiovascular Disease Cancer
Fluvastatin sodium (XU 62320) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC₅₀ of 8 nM. Fluvastatin sodium protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway.

HY-112537B

D-Glucose 6-phosphate sodium
Endogenous Metabolite Metabolic Disease

D-Glucose 6-phosphate sodium is an endogenous metabolite.
HY-16581A

DL-threo-2-methylisocitrate sodium
Others Infection

DL-threo-2-methylisocitrate is a substrate of isocitrate lyase 1(ICL1).

HY-15568A

*A-317491 sodium* salt hydrate**	P2X Receptor Autophagy	Neurological Disease Cancer
A-317491 sodium salt hydrate is a non-nucleotide P2X3 and P2X2/3 receptor antagonist, which inhibits calcium flux mediated by the receptors.

HY-B1202A

Alrestatin sodium AY-22284A	Aldose Reductase	Endocrinology
Alrestatin sodium is an inhibitor of aldose reductase, an enzyme involved in the pathogenesis of complications of diabetes mellitus, including diabetic neuropathy.

HY-W010820

*Uridine 5'-diphosphate sodium* salt**	P2Y Receptor DNA/RNA Synthesis Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
Uridine 5'-diphosphate sodium salt is a potent, selective P2Y₆ receptor native agonist (EC₅₀=300 nM; pEC₅₀=6.52) and a potent P2Y₁₄ antagonist (pEC₅₀=7.28). Uridine 5'-diphosphate sodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis.

HY-B0712B

Ceftriaxone sodium salt
Disodium ceftriaxone
Bacterial Antibiotic Infection Cancer

Ceftriaxone sodium salt is an antibiotic useful for the treatment of a number of bacterial infections.
HY-B0491A

Carbazochrome sodium sulfonate
AC-17
Adrenergic Receptor Cardiovascular Disease Endocrinology

Carbazochrome (sodium sulfonate) (AC-17) is an antihemorrhagic agent.

HY-125785A

2-Mercaptopyridine N-oxide sodium	Bacterial	Infection
2-Mercaptopyridine N-oxide sodium has bactericidal effect and is against a standard strain of Mycobacterium tuberculosis H37Rv (ATCC 27294) with MIC₉₀ of 7.20 μM. 2-Mercaptopyridine N-oxide sodium and its complex with iron, gallium, and bismuth have good anti-M. tuberculosis activity. 2-Mercaptopyridine N-oxide sodium has potential for the treatment of tuberculosis.

HY-100652A

O-Desmethyl apixaban sulfate sodium	Factor Xa	Cardiovascular Disease
O-Desmethyl apixaban sulfate sodium is a major circulating metabolite of Apixaban in humans. O-Desmethyl apixaban sulfate sodium inhibits factor X (FXa) with a K_i of 58 μM.

HY-123687

DBCO-Sulfo-NHS ester sodium
ADC Linker Cancer

DBCO-Sulfo-NHS ester sodium is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-N7386A

D-Erythrose 4-phosphate sodium	Others	Metabolic Disease
D-Erythrose 4-phosphate sodium is a phosphate sodium of the simple sugar Erythrose. Erythritol is actually converted into D-Erythrose 4-phosphate that involves three isomerases.

HY-N0677B

*Dehydroandrographolide succinate potassium sodium* salt**	Others	Infection Inflammation/Immunology
Dehydroandrographolide succinate (potassium sodium salt), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, is widely used for the treatment of viral pneumonia and viral upper respiratory tract infections because of its immunostimulatory, anti-infective and anti-inflammatory effect.

HY-B0512A

Sulfamerazine sodium salt
Soluble sulfamerazine
Bacterial Antibiotic Infection

Sulfamerazine Sodium is a sulfonamide antibacterial.

HY-136347

3α-Hydroxy pravastatin sodium	HMG-CoA Reductase (HMGCR) Drug Metabolite	Cardiovascular Disease
3α-Hydroxy pravastatin sodium is the major metabolite of Pravastatin. Pravastatin is a competitive HMG-CoA reductase inhibitor.

HY-141268

Methyltetrazine-Sulfo-NHS ester sodium
PROTAC Linker Cancer

Methyltetrazine-Sulfo-NHS ester (sodium) is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-B0564

Sodium nitroprusside
Ro 21-2498
Others Cancer Cardiovascular Disease

Sodium nitroprusside (Ro 21-2498) is a potent vasodilator working through releasing NO spontaneously in blood.

HY-12811

PF-04856264	Sodium Channel	Neurological Disease
PF-04856264 is a potent and selective Nav1.7 inhibitor, with IC₅₀s of 28, 131, 19, and 42 nM for human, mouse, cynomolgus monkey and dog Nav1.7, respectively. PF-04856264 has low potency against the rat Nav1.7 channel. PF-04856264 shows analgesic effect.

HY-D0143B

Quinine hemisulfate hydrate	Parasite Potassium Channel	Infection
Quinine hemisulfate hydrate is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine hemisulfate hydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM.

HY-112217A

PSEM 89S TFA	nAChR	Neurological Disease
PSEM 89S TFA is a selective and brain penetrant agonists for the resulting ion channels. PSEM 89S TFA is orthogonally selective for Q79G and L141F, respectively.

HY-D0143

Quinine	Parasite Potassium Channel	Infection
Quinine is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM.

HY-110189

*Pregnenolone monosulfate sodium* salt** 3β-Hydroxy-5-pregnen-20-one monosulfate sodium salt	Cannabinoid Receptor Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone monosulfate sodium salt (3β-Hydroxy-5-pregnen-20-one monosulfate sodium salt) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium salt acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium salt can protect the brain from cannabis intoxication.

HY-B0712A

*Ceftriaxone sodium* hydrate** Ceftriaxone disodium hemiheptahydrate	Bacterial Antibiotic	Infection
Ceftriaxone sodium hydrate is an antibiotic useful for the treatment of a number of bacterial infections; a third-generation cephalosporin.

HY-B0879A

*Suramin sodium* salt** Suramin hexasodium salt	Phosphatase Sirtuin Reverse Transcriptase Topoisomerase Parasite Apoptosis	Cancer Infection Cardiovascular Disease
Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor. Suramin sodium salt is a potent inhibitor of sirtuins: SirT1 (IC₅₀=297 nM), SirT2 (IC₅₀=1.15 μM), and SirT5 (IC₅₀=22 μM). Suramin sodium salt is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC₅₀=5 μM). Suramin sodium salt efficiently inhibits IP5K and is an antiparasitic, anti-neoplastic and anti-angiogenic agent.

HY-126495A

Sulfo-SPDP-C6-NHS sodium
ADC Linker Cancer

Sulfo-SPDP-C6-NHS sodium is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-B0798

Cefpiramide sodium SM-1652; Wy-44635	Bacterial Antibiotic	Infection
Cefpiramide sodium (SM-1652; Wy-44635) is a new Pseudomonas-active cephalosporin with a broad spectrum of antibacterial activity.

HY-14879B

*Avibactam sodium* hydrate** NXL-104 hydrate	Bacterial Antibiotic	Infection
Avibactam sodium hydrate (NXL-104 hydrate) is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC₅₀s of 8 nM and 5 nM, respectively.

HY-13625

Ertapenem sodium L-749345; MK-826	Bacterial Antibiotic	Infection Cancer
Ertapenem sodium is a new long-acting 1-β-methyl carbapenem antibiotic with a broad antibacterial spectrum including common aerobic and anaerobic bacteria and organisms with extended-spectrum β-lactamases.

HY-14657

Dantrolene sodium
F 440
Calcium Channel Metabolic Disease

Dantrolene sodium is a inhibitor of calcium channel proteins, inhibiting the release of Ca2+ from the sarcoplasm.

HY-15037

Diclofenac Sodium GP 45840	COX Apoptosis	Inflammation/Immunology
Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.

HY-B0667A

*Balsalazide sodium* hydrate** Balsalazide disodium dihydrate	Interleukin Related STAT	Inflammation/Immunology Cancer
Balsalazide sodium hydrate could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.

HY-B0210A

*Cefoperazone sodium* salt** CP 52640-2	Bacterial Antibiotic	Infection
Cefoperazone sodium salt is a cephalosporin antibiotic for inhibition of rMrp2-mediated [3H]E217βG uptake with IC50 of 199 μM.

HY-135374

(3R,5S)-Atorvastatin sodium	Others	Metabolic Disease Inflammation/Immunology
(3R,5S)-Atorvastatin sodium is an impurity of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin inhibits human SV-SMC proliferation and invasion with IC₅₀s of 0.39 μM and 2.39 μM, respectively.

HY-N6612A

D-Glucuronic acid sodium salt monohydrate
Endogenous Metabolite Metabolic Disease

D-Glucuronic acid sodium salt monohydrate is an endogenous metabolite.

HY-13967A

*AMG 837 sodium* salt**	GPR40	Metabolic Disease
AMG 837 sodium salt is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents.

HY-B0320A

Cromolyn sodium Disodium Cromoglycate; FPL-670	Calcium Channel GSK-3	Inflammation/Immunology
Cromolyn sodium (Disodium Cromoglycate; FPL-670) is an antiallergic drug. Cromolyn sodium is a GSK-3β inhibitor with an IC₅₀ of 2.0 µM.

HY-15778A

*AVE 0991 sodium* salt**	Angiotensin Receptor	Cardiovascular Disease Endocrinology
AVE 0991 sodium salt is a nonpeptide and orally active Ang-(1-7) receptor Mas agonist. AVE 0991 competes for high-affinity binding of [¹²⁵I]-Ang-(1-7) to bovine aortic endothelial cell membranes with IC₅₀ of 21 nM.

HY-13063

Sodium formononetin-3'-sulfonate
Sul-F
Reactive Oxygen Species Cardiovascular Disease

Sodium formononetin-3'-sulfonate (Sul-F) is a water-sol.
HY-101705

Tibenelast sodium
LY 186655
Phosphodiesterase (PDE) Inflammation/Immunology

Tibenelast sodium is a phosphodiesterase inhibitor.

HY-100005A

*Fumarate hydratase-IN-2 sodium* salt**	Mitochondrial Metabolism	Cancer
Fumarate hydratase-IN-2 sodium salt (compound 3) is a cell-permeable and competitive fumarate hydratase inhibitor (K_i=4.5 μM) with nutrient-dependent cytotoxicity .

HY-135412

N-Methyl Duloxetine hydrochloride	Sodium Channel	Neurological Disease
N-Methyl Duloxetine hydrochloride is an analgesic. N-Methyl Duloxetine (hydrochloride) elicits both tonic and use-dependent block of neuronal Na⁺ channels.

HY-136564

DAD dichloride	Potassium Channel	Neurological Disease
DAD dichloride is a type of ion channel blocker that blocks voltage-gated potassium channels. DAD dichloride is a third-generation photoswitch that responds to visible light. DAD dichloride has the potential for restoring visual function.

HY-136564A

DAD	Potassium Channel	Neurological Disease
DAD is a type of ion channel blocker that blocks voltage-gated potassium channels. DAD is a third-generation photoswitch that responds to visible light. DAD has the potential for restoring visual function.

HY-124906

JAMI1001A	iGluR	Neurological Disease
JAMI1001A is a positive allosteric modulator of AMPA receptor. JAMI1001A efficaciously modulates AMPA receptor deactivation and desensitization of both flip and flop receptor isoforms.

HY-116282D

*Dextran sulfate sodium* salt (MW 450000-550000)**	Apoptosis HIV	Inflammation/Immunology
Dextran sulfate sodium salt (MW 450000-550000) is a is a polymer of anhydroglucose with the molecular weight range of 450000-550000. Dextran sulfate sodium salt inhibits the replication of the human immunodeficiency virus by preventing the adsorption of the virus into host cells.

HY-116282C

*Dextran sulfate sodium* salt (MW 35000-45000)**	Apoptosis HIV	Inflammation/Immunology
Dextran sulfate sodium salt (MW 35000-45000) is a is a polymer of anhydroglucose with the molecular weight range of 35000-45000. Dextran sulfate sodium salt inhibits the replication of the human immunodeficiency virus by preventing the adsorption of the virus into host cells.

HY-107785

2-Deoxy-2-sulfoamino-D-glucose sodium
Endogenous Metabolite Metabolic Disease

2-Deoxy-2-sulfoamino-D-glucose sodium is an endogenous metabolite.

HY-B0890

*Zomepirac sodium* salt** McN-2783-21-98	PGE synthase	Inflammation/Immunology
Zomepirac sodium salt is a pyrrole-acetic acid structurally related to tolmetin sodium; a prostaglandin synthetase inhibitor.

HY-116282A

*Dextran sulfate sodium* salt (MW 4500-5500)**	Apoptosis HIV	Inflammation/Immunology
Dextran sulfate sodium salt (MW 4500-5500) is a is a polymer of anhydroglucose with the molecular weight range of 4500-5500. Dextran sulfate sodium salt inhibits the replication of the human immunodeficiency virus by preventing the adsorption of the virus into host cells.

HY-19555A

*Seco Rapamycin sodium* salt** Secorapamycin A monosodium	Others	Inflammation/Immunology
Seco Rapamycin sodium salt is the ring-opened product of Rapamycin. Seco-rapamycin is reported not to affect the mTOR function.

HY-116282B

*Dextran sulfate sodium* salt (MW 16000-24000)**	Apoptosis HIV	Inflammation/Immunology
Dextran sulfate sodium salt (MW 16000-24000) is a is a polymer of anhydroglucose with the molecular weight range of 16000-24000. Dextran sulfate sodium salt inhibits the replication of the human immunodeficiency virus by preventing the adsorption of the virus into host cells.

HY-B1888B

*Bromfenac sodium* hydrate** Bromfenac monosodium salt sesquihydrate	Others	Inflammation/Immunology
Bromfenac sodium hydrate (Bromfenac monosodium salt sesquihydrate) is a nonsteroidal anti-inflammatory agent (NSAID), which has anti-inflammatory activity.

HY-17451

Glibornuride
Potassium Channel Metabolic Disease

Glibornuride is a blocker of ATP-sensitive K⁺ channels (K_ATP channel) with a pK_i of 5.75. Antidiabetic agent.
HY-W009362

Sodium 1-hydroxypropane-1,2,3-tricarboxylate hydrate
Endogenous Metabolite Metabolic Disease

Sodium 1-hydroxypropane-1,2,3-tricarboxylate hydrate is an endogenous metabolite.

HY-16344

Nedocromil sodium FPL 59002KP; Nedocromil disodium salt	Histamine Receptor Leukotriene Receptor Prostaglandin Receptor	Inflammation/Immunology Endocrinology
Nedocromil sodium suppresses the action or formation of multiple mediators, including histamine, leukotriene C₄ (LTC₄), and prostaglandin D₂ (PGD₂).

HY-101325

BRL 37344 sodium BRL 37344A	Adrenergic Receptor	Metabolic Disease Endocrinology
BRL 37344 sodium (BRL 37344A) is a specific β3-adrenergic receptor agonist. BRL 37344 sodium treatment significantly lowers the body weight of obese mice.

HY-113437A

1,2-Dipalmitoyl-sn-glycerol 3-phosphate sodium	Endogenous Metabolite	Metabolic Disease
1,2-Dipalmitoyl-sn-glycerol 3-phosphate sodium (compound 3-F7) is a phosphatidic acid and a human endogenous metabolite

HY-B1318

Foscarnet sodium Trisodium phosphonoformate; Phosphonoformic acid trisodium salt	Virus Protease DNA/RNA Synthesis	Infection
Foscarnet sodium (Trisodium phosphonoformate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet sodium is an antiherpesvirus agent used in cytomegalovirus retinitis.

HY-B0515

*Ibandronate Sodium* Monohydrate** BM-210955; RPR-102289A	Apoptosis	Cancer
Ibandronate Sodium Monohydrate is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis.

HY-A0176

Glisoxepide	Potassium Channel	Metabolic Disease Cardiovascular Disease
Glisoxepide, a sulphonamide derivative, is an orally available nonselective K(ATP) channel blocker, with antihyperglycemic activity and cardiovascular regulation effect.

HY-14664AS

Fluvastatin D6 sodium XU 62-320 (D6)	HMG-CoA Reductase (HMGCR) Autophagy	Cardiovascular Disease Cancer
Fluvastatin D6 sodium (XU 62-320 D6) is deuterium labeled Fluvastatin sodium. Fluvastatin sodium (XU 62320) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC₅₀ of 8 nM.

HY-110105

NS8593 hydrochloride	Potassium Channel	Neurological Disease
NS8593 hydrochloride is a potent and selective small conductance Ca²⁺-activated K⁺ channels (SK channels) inhibitor. NS8593 hydrochloride reversibly inhibits SK3-mediated currents with a K_d value of 77 nM. NS8593 hydrochloride inhibits all the SK1-3 subtypes Ca²⁺-dependently (K_ds of 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca²⁺), and does not affect the Ca²⁺-activated K⁺ channels of intermediate and large conductance (hIK and hBK channels, respectively).

HY-110237

BX430	P2X Receptor Calcium Channel	Cardiovascular Disease
BX430 is a potent and selective noncompetitive allosteric human P2X4 receptor channels antagonist with an IC₅₀ of 0.54 μM. BX430 has species specificity. BX430 is used for chronic pain and cardiovascular disease.

HY-B0563C

Ropivacaine mesylate	Potassium Channel	Neurological Disease Cardiovascular Disease
Ropivacaine mesylate is an aminoamide compound, effectively blocks neuropathic pain. Ropivacaine mesylate is an inhibitor of K_2P (two-pore domain potassium channel) TREK-1 with an IC₅₀ of 402.7 μM in COS-7 cell's membrane. Ropivacaine mesylate inhibits pressure-induces lung endothelial hyperpermeability in models of acute hypertension.

HY-116330A

Hyperforin dicyclohexylammonium salt Hyperforin DCHA	TRP Channel Calcium Channel	Neurological Disease
Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin dicyclohexylammonium salt modulates Ca²⁺ levels by activating Ca²⁺-conducting non-selective canonical TRPC6 channels. Hyperforin dicyclohexylammonium salt shows antidepressant effect.

HY-B0563A

Ropivacaine hydrochloride monohydrate	Potassium Channel	Neurological Disease Cardiovascular Disease
Ropivacaine hydrochloride monohydrate is an aminoamide compound, effectively blocks neuropathic pain. Ropivacaine hydrochloride monohydrate is an inhibitor of K_2P (two-pore domain potassium channel) TREK-1 with an IC₅₀ of 402.7 μM in COS-7 cell's membrane. Ropivacaine hydrochloride monohydrate inhibits pressure-induces lung endothelial hyperpermeability in models of acute hypertension.

HY-103369

PG01	CFTR	Endocrinology
PG01 is a potent CFTR Cl^- channel potentiator. PG01 can correct gating defects of CFTR mutants, is effective on b>E193K, G970R and G551D (CFTR mutants) with K_d values of 0.22 μM, 0.45 μM and 1.94 μM, respectively. PG01 is also effective on ΔF508 (K_a of 0.3 μM). PG01 increases ΔF508-CFTR Cl^- current after adding Forskolin.

HY-14945

Remogliflozin etabonate GSK189075	SGLT	Metabolic Disease
Remogliflozin etabonate (GSK189075) is an orally active, selective and low-affinity sodium glucose cotransporter (SGLT2) inhibitor with K_i values of 1.95 μM, 2.14 μM, 43.1 μM, 8.57 μM for hSGLT2, rSGLT2, hSGLT1, rSGLT1, respectively. Remogliflozin etabonate is a prodrug based on benzylpyrazole glucoside and is metabolized to its active form, Remogliflozin, in the body. Remogliflozin etabonate exhibits antidiabetic efficacy in rodent models.

HY-122872

MKK7-COV-9	p38 MAPK	Cancer
MKK7-COV-9 is a potent and selective covalent inhibitor of MKK7 and targets a specific protein–protein interaction of MKK7. MKK7-COV-9 blocks primary B cell activation in response to LPS with an EC₅₀ of 4.98 μM.

HY-B1654A

Flavin Adenine Dinucleotide Disodium FAD-Na2; FAD sodium salt	Endogenous Metabolite	Cardiovascular Disease
Flavin Adenine Dinucleotide Disodium is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism.

HY-108586

NS3623	Potassium Channel	Neurological Disease
NS3623 is an activator of human ether-a-go-go-related gene (hERG1/K_V11.1) potassium channels. NS3623 activates the IKr and Ito currents and has antiarrhythmic effect. NS3623 has a dual mode of action, being an inhibitor of hERG1 channels.

HY-11101

Alendronate sodium hydrate
Alendronate; MK 217; G-704650 Adronat
Others Cancer

Alendronate (sodium hydrate) is a farnesyl diphosphate synthase inhibitor with IC₅₀ of 460 nM.

HY-B1610

Sodium citrate dihydrate Trisodium citrate dihydrate; Citric acid trisodium salt dihydrate	Bacterial	Infection Cardiovascular Disease
Sodium citrate dehydrate is an anticoagulant and also used as a buffer and food preservatives.

HY-W020468

Linopirdine DuP 996	Potassium Channel TRP Channel	Neurological Disease
Linopirdine (DuP 996) is an orally active, selective M-type K⁺ current (IM; Kv7; KCNQ Channels) inhibitor with an IC₅₀ of 2.4 μM. Linopirdine is a TRPV1 agonist. Linopirdine, a putative cognition enhancing drug, increases acetylcholine release in rat brain tissue.

HY-P1280

Margatoxin	Potassium Channel	Neurological Disease
Margatoxin, an alpha-KTx scorpion toxin, is a high affinity inhibitor of Kv1.3 (K_d=11.7 pM). Margatoxin inhibits the Kv1.2 (K_d=6.4 pM) and Kv1.1 (K_d=4.2 nM). Margatoxin, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research.

HY-130605

BAY-1797	P2X Receptor	Neurological Disease
BAY-1797 is a potent, orally active, and selective P2X4 antagonist, with an IC₅₀ of 211 nM against human P2X4. BAY-1797 displays no or very weak activity on the other P2X ion channels. BAY-1797 shows anti-nociceptive and anti-inflammatory effects.

HY-P1136A

Gap19 TFA	Gap Junction Protein	Cardiovascular Disease
Gap19 TFA, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 TFA inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 TFA is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 TFA has protective effects against myocardial.

HY-P1136

Gap19	Gap Junction Protein	Cardiovascular Disease
Gap19, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 has protective effects against myocardial.

HY-122051

AC1903	TRP Channel	Metabolic Disease
AC1903 is a specific and selective inhibitor of TRPC5 and has podocyte-protective properties. AC1903 does no effects on TRPC4 or TRPC6 currents and shows no off-target effects in kinase profiling assays. AC1903 suppresses severe proteinuria and prevents podocyte loss in focal segmental glomerulosclerosis (FSGS) rat model.

HY-110358

QAQ dichloride	Sodium Channel	Inflammation/Immunology
QAQ dichloride, a photoswitchable voltage-gated Na_v and K_v channels blocker, blocks channels in its trans form (of the azobenzene photoswitch), but not in its cis form. QAQ dichloride is membrane-impermeant and only infiltrates pain-sensing neurons that express endogenous import channels. QAQ dichloride acts as a light-sensitive analgesic and can be used for studying of signaling mechanisms in acute and chronic pain.

HY-106916

Unoprostone	Potassium Channel	Neurological Disease
Unoprostone, a prostaglandin F2α analogs (PGAs), activates BK channels to reduce oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction. Unoprostone reduces intraocular pressure and is used topically for glaucoma or ocular hypertension.

HY-16477

Talaporfin sodium
ME2906; Mono-L-aspartyl chlorin e6; NPe6
Others Others

Talaporfin (ME2906; NPe6) is a photosensitizer used in photodynamic therapy (PDT).

HY-14664C

(3S,5R)-Fluvastatin sodium (3S,5R)-XU 62-320	HMG-CoA Reductase (HMGCR)	Cancer Cardiovascular Disease
(3S,5R)-Fluvastatin sodium ((3S,5R)-XU 62-320) is the (3S,5R)-enantiomer of Fluvastatin. Fluvastatin is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC₅₀ of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway.

HY-14664CS

(3S,5R)-Fluvastatin D6 sodium (3S,5R)-XU 62-320 D6	HMG-CoA Reductase (HMGCR)	Cancer Cardiovascular Disease
(3S,5R)-Fluvastatin D6 sodium is the deuterium labeled (3S,5R)-Fluvastatin sodium. Fluvastatin is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC₅₀ of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway.

HY-120944

BAY-7598	MMP	Inflammation/Immunology
BAY-7598 is a potent, orally bioavailable, and selective MMP12 inhibitor probe with IC₅₀s of 0.085, 0.67 and 1.1 nM for human MMP12, murine MMP12, and rat MMP12, respectively.

Cat. No.	Product Name	Type