Search Result
Results for "Anti mir ™ mirna Inhibitors" in MCE Product Catalog:
1907
Inhibitors & Agonists
2
Biochemical Assay Reagents
| Cat. No. |
Product Name |
Target |
Research Areas |
-
- HY-15843
-
|
MIR96-IN-1
|
MicroRNA
Apoptosis
|
Cancer
|
|
MIR96-IN-1 selectively inhibits biogenesis of microRNA-96, upregulating a protein target (FOXO1) and inducing apoptosis in cancer cells.
|
-
- HY-19731
-
-
- HY-135276
-
|
Targaprimir-96
|
MicroRNA
Apoptosis
|
Cancer
|
|
Targaprimir-96 is a potent inhibitor of microRNA-96 (miR-96) processing. Targaprimir-96 selectively modulates miR-96 production in cancer cells and triggers apoptosis. Targaprimir-96 binds primary miR-96 (pri-miR-96) with low nanomolar affinity. Targaprimir-96 directly engages pri-miR-96 in breast cancer cells and is ineffective on healthy breast cells.
|
-
- HY-135276A
-
|
Targaprimir-96 TFA
|
MicroRNA
Apoptosis
|
Cancer
|
|
Targaprimir-96 TFA is a potent inhibitor of microRNA-96 (miR-96) processing. Targaprimir-96 TFA selectively modulates miR-96 production in cancer cells and triggers apoptosis. Targaprimir-96 TFA binds primary miR-96 (pri-miR-96) with low nanomolar affinity. Targaprimir-96 TFA directly engages pri-miR-96 in breast cancer cells and is ineffective on healthy breast cells.
|
-
- HY-U00439
-
-
- HY-15861
-
|
Targapremir-210
TGP-210
|
MicroRNA
Apoptosis
|
Cancer
|
|
Targapremir-210 (TGP-210) is a potent and selective miR-210 inhibitor. Targapremir-210 inhibits pre-miR-210 processing with high binding affinity (Kd~200 nM).
|
-
- HY-126295
-
-
- HY-U00273
-
-
- HY-126131
-
|
anti-TB agent 1
|
Bacterial
|
Infection
|
|
anti-TB agent 1 is a potent and orally active anti-tuberculosis agent, with MICs of < 2 nM against the Mtb strains H37Rv, rRMP and rINH.
|
-
- HY-131233
-
|
Anti-virus agent 1
|
Others
|
Infection
|
|
Anti-virus agent 1 (compound 4i), a phosphoramidate prodrug of GS-5734 (HY-104077; Remdesivir), has potent antiviral activity. Anti-virus agent 1 is used for the research of coronavirus and Ebola virus (EBOV).
|
-
- HY-U00314
-
-
- HY-U00301
-
-
- HY-101729
-
-
- HY-P9917
-
|
Tocilizumab
Anti-Human IL6R, Humanized Antibody
|
Interleukin Related
|
Cancer
Inflammation/Immunology
|
|
Tocilizumab (Anti-Human IL6R, Humanized Antibody) is an anti-human interleukin-6 receptor (IL-6R) neutralizing antibody, prevents binding of IL-6 to the IL-6R, thereby inhibiting both classic and trans-signaling. Tocilizumab (Anti-Human IL6R, Humanized Antibody) can be used for the treatment of rheumatoid arthritis. Tocilizumab is remarkablely effective for the study of severe COVID-19 (coronavirus disease).
|
-
- HY-116716
-
|
PIN1 inhibitor API-1
|
MicroRNA
|
Cancer
|
|
PIN1 inhibitor API-1 is a specific Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) inhibitor (API-1) with an IC50 of 72.3 nM. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase (PPIase) domain and potently inhibits Pin1 cis-trans isomerizing activity. PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development.
|
-
- HY-P9909
-
-
- HY-B0185A
-
|
Lidocaine hydrochloride
Lignocaine hydrochloride
|
Sodium Channel
MEK
ERK
NF-κB
Apoptosis
|
Cancer
Cardiovascular Disease
|
|
Lidocaine hydrochloride (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence. Lidocaine hydrochloride decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride is an amide derivative commonly used to anesthetize. hydrochloride is a a drug to treat ventricular arrhythmia and an effective tumor-inhibitor.
|
-
- HY-B0185
-
|
Lidocaine
Lignocaine
|
Sodium Channel
MEK
ERK
NF-κB
Apoptosis
|
Cancer
Cardiovascular Disease
|
|
Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence. Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative commonly used to anesthetize. Lidocaine is a drug to treat ventricular arrhythmia and an effective tumor-inhibitor.
|
-
- HY-17624
-
|
Framycetin
Neomycin B; Fradiomycin B
|
Bacterial
|
Infection
|
|
Framycetin (Neomycin B), an aminoglycoside antibiotic, is a potent RNase P cleavage activity inhibitor with a Ki of 35 μM. Framycetin competes for specific divalent metal ion binding sites in RNase P RNA. Framycetin inhibits hammerhead ribozyme with a Ki of 13.5 μM. Framycetin, a 5″-azido neomycin B precursor, binds the Drosha site in miR-525 and is used for hepatic encephalopathy and enteropathogenic E. coli infections.
|
-
- HY-P9916
-
|
Sarilumab
Anti-Human IL6Rα, Human Antibody
|
Interleukin Related
|
Inflammation/Immunology
|
|
Sarilumab (Anti-Human IL6Rα, Human Antibody) is a human immunoglobulin G1 monoclonal antibody. Sarilumab, a interleukin-6 (IL-6) receptor antagonist, binds to the IL-6 receptor with high affinity and inhibits cis and trans signaling by IL-6, resulting in reduced inflammation. Sarilumab can be used for the research of Rheumatoid arthritis.
|
-
- HY-17624A
-
|
Framycetin sulfate
Neomycin B sulfate; Fradiomycin B sulfate
|
Bacterial
|
Infection
|
|
Framycetin sulfate (Neomycin B sulfate), an aminoglycoside antibiotic, is a potent RNase P cleavage activity inhibitor with a Ki of 35 μM. Framycetin sulfate competes for specific divalent metal ion binding sites in RNase P RNA. Framycetin sulfate inhibits hammerhead ribozyme with a Ki of 13.5 μM. Framycetin sulfate, a 5″-azido neomycin B precursor, binds the Drosha site in miR-525 and is used for hepatic encephalopathy and enteropathogenic E. coli infections.
|
-
- HY-P9803
-
|
Anti-SARS-80R mAb
SARS-80R; SARS Antibody-80R
|
SARS-CoV
|
Infection
|
|
Anti-SARS-80R mAb (SARS-80R) is a human monoclonal IgG1 antibody produced in CHO cells. Anti-SARS-80R mAb can specifically bind to Spike (S1) protein to prevent SARS virus infection of susceptible cells.
|
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- HY-P9806
-
|
Anti-MERS-D12 mAb
MERS-D12; MERS Antibody-D12
|
SARS-CoV
|
Infection
|
|
Anti-MERS-D12 mAb (MERS-D12; MERS Antibody-D12) is a human monoclonal IgG1. Anti-MERS-D12 mAb binds directly to the DPP4 interacting region of the MERS-CoV Spike receptor binding domain (RBD) and effect neutralization by directly blocking receptor binding.
|
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- HY-131005
-
-
- HY-100574A
-
|
Cl-amidine hydrochloride
|
Protein Arginine Deiminase
Apoptosis
MicroRNA
|
Cancer
Inflammation/Immunology
|
|
Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor, with IC50 values of 0.8 μM, 6.2 μM and 5.9 μM for PAD1, PAD3, and PAD4, respectively. Cl-amidine hydrochloride induces apoptosis in cancer cells. Cl-amidine hydrochloride induces microRNA (miR)-16 expression and causes cell cycle arrest. Cl-Amidine hydrochloride prevents histone 3 citrullination and neutrophil extracellular trap formation, and improves survival in a murine sepsis model.
|
-
- HY-100574
-
|
Cl-amidine
|
Protein Arginine Deiminase
Apoptosis
MicroRNA
|
Cancer
Inflammation/Immunology
|
|
Cl-amidine is an orally active peptidylarginine deminase (PAD) inhibitor, with IC50 values of 0.8 μM, 6.2 μM and 5.9 μM for PAD1, PAD3, and PAD4, respectively. Cl-amidine induces apoptosis in cancer cells. Cl-amidine induces microRNA (miR)-16 expression and causes cell cycle arrest. Cl-Amidine prevents histone 3 citrullination and neutrophil extracellular trap formation, and improves survival in a murine sepsis model.
|
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- HY-P9801
-
|
Anti-Spike-RBD mAb
SARS-CoV-2 (2019-nCoV) Spike RBD Antibody
|
SARS-CoV
|
Infection
|
|
Anti-Spike-RBD mAb is a CHO cell derived human monoclonal IgG1 antibody. Blocking the interaction of spike protein and ACE2 is a potential therapeutic approach for SARS-CoV-2 treatment.
|
-
- HY-108730
-
-
- HY-100574B
-
|
Cl-amidine TFA
|
Protein Arginine Deiminase
Apoptosis
MicroRNA
|
Cancer
Inflammation/Immunology
|
|
Cl-amidine TFA is an orally active peptidylarginine deminase (PAD) inhibitor, with IC50 values of 0.8 μM, 6.2 μM and 5.9 μM for PAD1, PAD3, and PAD4, respectively. Cl-amidine TFA induces apoptosis in cancer cells. Cl-amidine TFA induces microRNA (miR)-16 expression and causes cell cycle arrest. Cl-Amidine TFA prevents histone 3 citrullination and neutrophil extracellular trap formation, and improves survival in a murine sepsis model.
|
-
- HY-P9805
-
|
Anti-MERS-3A1 mAb
MERS-3A1; MERS Antibody-3A1
|
SARS-CoV
|
Infection
|
|
Anti-MERS-3A1 mAb (MERS-3A1) is a human monoclonal IgG1 antibody with the high binding affinity produced in CHO cells.
Anti-MERS-3A1 mAb bocks the binding of MERS-CoV spike protein to DPP4 receptor.
|
-
- HY-121879
-
-
- HY-N3977
-
|
Grifolic acid
|
GPR120
|
Inflammation/Immunology
|
|
Grifolic acid is a phenolic compound that is first extracted from the mushroom Albatrellus confluens. Grifolic acid acts as an agonist of the free fatty acid receptor (FFAR4/GPR120).
|
-
- HY-P9906
-
|
Bevacizumab
Anti-Human VEGF, Humanized Antibody
|
VEGFR
|
Cancer
|
|
Bevacizumab, a humanized monoclonal antibody, specifically binds to all VEGF-A isoforms with high affinity.
|
-
- HY-122470
-
|
Stampidine
|
Reverse Transcriptase
HIV
|
Infection
|
|
Stampidine is a nucleoside reverse transcriptase inhibitor (NRTI) with potent and broad-spectrum anti-HIV activity. Stampidine inhibits the laboratory HIV-1 strain HTLVIIIB (B-envelope subtype) and primary clinical isolates with IC50s of 1 nM and 2 nM, respectively. Stampidine also inhibits NRTI-resistant primary clinical isolates and NNRTI-resistant clinical isolates with IC50s of 8.7 nM and 11.2 nM, respectively.
|
-
- HY-19373
-
-
- HY-16787
-
|
ICA-121431
|
Sodium Channel
|
Cardiovascular Disease
|
|
ICA-121431 is a nanomolar potent and broad-spectrum voltage-gated sodium channel (Nav) blocker, shows equipotent selectivity for human Nav1.1 and Nav1.3 subtypes with IC50 values of 13 nM and 23 nM, respectively. ICA-121431 shows less potent inhibition of Nav1.2 (IC50=240 nM) and 1,000 fold selectivity against Nav1.4, Nav1.6, and the TTX-resistant human Nav1.5 and Nav1.8 channels (IC50s >10 µM).
|
-
- HY-P9802
-
|
Anti-Spike-RBD Single Domain mAb
SARS-CoV-2 (2019-nCoV) Single-Domain Antibodies; Humanized Single Domain Antibody
|
SARS-CoV
|
Infection
|
|
Anti-Spike-RBD Single Domain mAb is a CHO cell derived Alpaca monoclonal VHH-huFc antibody, specifically binds to SARS-CoV-2 RBD with high affinity.
|
-
- HY-P9804
-
|
Anti-MERS-2E6 mAb
MERS-2E6; MERS Antibody-2E6
|
SARS-CoV
|
Infection
|
|
Anti-MERS-2E6 mAb (MERS-2E6; MERS Antibody-2E6), a human neutralizing antibody IgG1 (CHO expressed) that can compete for the binding of the virus Spike protein to the receptor (CD26), thereby inhibiting virus invasion into host cells.
|
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- HY-P9907
-
|
Trastuzumab
Anti-Human HER2, Humanized Antibody
|
EGFR
|
Cancer
|
|
Trastuzumab is a humanized monoclonal antibody for patients with invasive breast cancers that overexpress HER2. Trastuzumab has the potential for HER2 Positive Metastatic Breast Cancer and HER2 Positive Gastric Cancer research.
|
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- HY-P9908
-
-
- HY-P9807
-
-
- HY-U00439A
-
|
Protein kinase inhibitors 1 hydrochloride
(E)-5-((2-Oxo-6'-(piperazin-1-yl)-1,2-dihydro-[3,3'-bipyridin]-5-yl)methylene)thiazolidine-2,4-dione hydrochloride
|
DYRK
|
Cancer
|
|
Protein kinase inhibitors 1 hydrochloride is a potent HIPK2 inhibitor, with IC50s of 136 and 74 nM for HIPK1 and HIPK2, and a Kd of 9.5 nM for HIPK2.
|
-
- HY-W012037
-
|
8-Hydroxyquinoline hemisulfate
8-Quinolinol hemisulfate
|
Bacterial
Antibiotic
|
Infection
|
|
8-Hydroxyquinoline hemisulfate (8-Quinolinol hemisulfate) is a monoprotic bidentate chelating agent, exhibits antiseptic, disinfectant, and pesticide properties, functioning as a transcription inhibitor.
|
-
- HY-135813
-
|
LtaS-IN-1
|
Bacterial
|
Infection
|
|
LtaS-IN-1 (compound 1771) is a potent small-molecule inhibitor of Lipoteichoic acid (LTA) synthesis in multidrug-resistant (MDR) E. faecium and by altering the cell wall morphology. LtaS-IN-1 alone inhibits Enterococcus.spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 combination with antibiotics abolishs multidrug-resistant E. faecium growth almost completely.
|
-
- HY-125957
-
|
A-3 hydrochloride
|
PKA
Casein Kinase
CaMK
PKC
|
Others
|
|
A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It against PKA (Ki=4.3 µM), casein kinase II (Ki=5.1 µM) and myosin light chain kinase (MLCK) (Ki=7.4 µM). A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 µM and 80 µM, respectively.
|
-
- HY-101918
-
|
DS-1040 Tosylate
|
Others
|
Cardiovascular Disease
|
|
DS-1040 Tosylate is an orally active, selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) with IC50s of 5.92 nM and 8.01 nM for human and rat TAFIa. DS-1040 Tosylate is a fibrinolysis enhancer for thromboembolic diseases.
|
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- HY-18728
-
-
- HY-P9911
-
|
Vedolizumab
Anti-Human lymphocyte α4β7 integrin, Humanized Antibody
|
Integrin
|
Inflammation/Immunology
|
|
Vedolizumab is a humanized monoclonal antibody that targets the α4β7 integrin for the treatment of ulcerative colitis and Crohn's disease.
|
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- HY-15583
-
-
- HY-11007
-
|
GNF-2
|
Bcr-Abl
SARS-CoV
|
Cancer
|
|
GNF-2 is a highly selective, allosteric, non-ATP competitive inhibitor of Bcr-Abl. GNF-2 inhibits Ba/F3.p210 proliferation with an IC50 of 138 nM .
|
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- HY-N6656
-
-
- HY-N2302
-
-
- HY-N0126
-
-
- HY-N0570
-
-
- HY-Y1825
-
|
Benzimidazole
|
Bacterial
Fungal
Influenza Virus
Parasite
|
Cancer
Infection
Inflammation/Immunology
|
|
Benzimidazole is a heterocyclic aromatic organic compound and acts as an important pharmacophore in medicinal chemistry. Benzimidazole derivatives have been reported to possess various biological activities such as anti-cancer, anti-viral, anti-bacterial, anti-fungal, anti-helmintic, anti-inflammatory, proton pump inhibitor and anti-coagulant property.
|
-
- HY-N0664
-
|
Aucubin
|
HBV
|
Inflammation/Immunology
Cancer
|
|
Aucubin is an iridoid glycoside with a wide range of biological activities, including anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities.
|
-
- HY-N6980
-
|
Licorice glycoside C2
|
Others
|
Cancer
Infection
|
|
Licorice glycoside C2 is a oleanane-type triterpene oligoglycoside isolated from Glycyrrhiza uralensis. Various biological activities are associated with licorice extracts, such as anti-viral, anti-microbial, antioxidant, anti-inflammatory, anti-ulcer, anti-cancer and anti-HIV effects.
|
-
- HY-N0452
-
-
- HY-N0018
-
|
Daidzin
Daidzoside; NPI-031D; Daidzein 7-O-glucoside
|
Mitochondrial Metabolism
Reverse Transcriptase
|
Others
|
|
Daidzin is an isoflavone that has anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities; directly inhibits mitochondrial aldehyde dehydrogenase 2 (IC50 = 80 nM) and is an effective anti-dipsotropic isoflavone.
|
-
- HY-100618
-
-
- HY-N0148
-
-
- HY-N2393
-
-
- HY-N0691
-
|
Schisandrin
Schizandrol; Schizandrol-A; Wuweizi alcohol-A; Wuweizichun-A
|
Autophagy
|
Inflammation/Immunology
Cancer
|
|
Schisandrin has various therapeutic effects on a range of medical conditions such as anti-asthmatic, anti-cancer, and anti-inflammatory effects.
|
-
- HY-18716
-
-
- HY-N0393
-
|
Glabridin
|
PPAR
Reactive Oxygen Species
Bacterial
|
Cancer
Infection
Inflammation/Immunology
|
|
Glabridin is a natural isoflavan from Glycyrrhiza glabra, binds to and activates PPARγ, with an EC50 of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities.
|
-
- HY-N0055
-
|
Chlorogenic acid
3-O-Caffeoylquinic acid; Heriguard; NSC-407296
|
HIF/HIF Prolyl-Hydroxylase
Reactive Oxygen Species
Bacterial
Influenza Virus
Endogenous Metabolite
|
Cancer
Infection
Inflammation/Immunology
|
|
Chlorogenic acid is a major phenolic compound in coffee and tea. It plays several important and therapeutic roles such as antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension.
|
-
- HY-N0250
-
-
- HY-N0783
-
-
- HY-B0729
-
|
Polaprezinc
Zinc L-carnosine
|
Others
|
Inflammation/Immunology
|
|
Polaprezinc is an orally bioavailable chelate composed of zinc and L-carnosine, with potential gastroprotective, anti-oxidant, anti-ulcer and anti-inflammatory activities.
|
-
- HY-N0519
-
|
Calycosin
Cyclosin
|
Apoptosis
|
Cancer
|
|
Calycosin (Cyclosin) is a natural active compound with anti-oxidative and anti-inflammation activity.
|
-
- HY-U00063
-
-
- HY-N4226
-
|
1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid
|
Others
|
Inflammation/Immunology
Cancer
|
|
1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid is from Cordyceps bassiana, which is one of Cordyceps species with anti-oxidative, anti-cancer, anti-inflammatory, anti-diabetic, anti-obesity, anti-angiogenic, and anti-nociceptive activities. 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid targets to block AP-1-mediated luciferase activity, implying it has an anti-inflammatory function.
|
-
- HY-N4103
-
-
- HY-W013332
-
-
- HY-W013332A
-
-
- HY-N0184B
-
-
- HY-N0741A
-
-
- HY-N0741
-
-
- HY-107470
-
-
- HY-N2032
-
|
Euphorbiasteroid
|
AMPK
|
Cancer
Infection
Metabolic Disease
|
|
Euphorbiasteroid is a tricyclic diperpene of Euphorbia lathyris L., inhibits tyrosinase, and increases the phosphorylation of AMPK, with anti-cancer, anti-virus, anti-obesity and multidrug resistance-modulating effect.
|
-
- HY-101737
-
-
- HY-N2590
-
|
Lupenone
|
Others
|
Cancer
Infection
Inflammation/Immunology
|
|
Lupenone, isolated from Rhizoma Musae, belongs to lupane type triterpenoids. Lupenone shows various pharmacological activities including anti-inflammatory, anti-virus, anti-diabetes, anti-cancer, improving Chagas disease without major toxicity.
|
-
- HY-N0036
-
-
- HY-N0181
-
-
- HY-N0820
-
-
- HY-15995
-
-
- HY-N0344
-
-
- HY-B1479C
-
-
- HY-B1479
-
-
- HY-N0013
-
-
- HY-B1479B
-
-
- HY-136203
-
-
- HY-N0609
-
|
Cinnamaldehyde
|
Bacterial
Apoptosis
|
Inflammation/Immunology
|
|
Cinnamaldehyde is a major and a bioactive compound isolated from the leaves of Cinnamomum osmophloeum kaneh. Cinnamaldehyde is a cytokine production inhibitor. Cinnamaldehyde has anti-bacteria, anti-oxidation, and anti-inflammatory properties.
|
-
- HY-B0289
-
-
- HY-N2542
-
-
- HY-N0101
-
-
- HY-N0007
-
|
Bisdemethoxycurcumin
Curcumin III; Didemethoxycurcumin
|
Apoptosis
Autophagy
|
Cancer
|
|
Bisdemethoxycurcumin(Curcumin III; Didemethoxycurcumin) is a natural derivative of curcumin with anti-inflammatory and anti-cancer activities.
|
-
- HY-B1215
-
-
- HY-B1048
-
|
Pasiniazid
Paraniazide; Pasiniazide; Isonicotinic acid hydrazide p-aminosalicylate
|
Others
|
Inflammation/Immunology
|
|
Pasiniazid is an anti-TB and anti-leprosy drug, used to treat various types of TB and leprosy.
|
-
- HY-B1436
-
-
- HY-19909
-
|
NRC-2694
|
EGFR
|
Cancer
|
|
NRC-2694 is an epidermal growth factor receptor (EGFR) antagonist with anti-cancer and anti-proliferative properties.
|
-
- HY-B1214
-
-
- HY-N0828
-
|
Pterostilbene
|
Autophagy
|
Cancer
Inflammation/Immunology
|
|
Pterostilbene is a stilbenoid isolated from blueberries and Pterocarpus marsupium. Shows anti-oxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic and anti-obesity properties. Pterostilbene blocks ROS production, also exhibits inhibitory activity against various free radicals such as DPPH, ABTS, hydroxyl, superoxide and hydrogen peroxide.
|
-
- HY-N7044
-
-
- HY-10529
-
-
- HY-N0334
-
|
(+)-Magnoflorine
Magnoflorine; α-Magnoflorine; Thalictrine
|
Fungal
|
Infection
Metabolic Disease
|
|
(+)-Magnoflorine (Magnoflorine), an aporphine alkaloid found in Acoruscalamus, reduces the formation of C. albicans biofilm. (+)-Magnoflorine has anti-fungal, anti-antidiabetic and anti-oxidative activity.
|
-
- HY-N0535
-
|
(+)-Magnoflorine chloride
Magnoflorine chloride; α-Magnoflorine chloride; Thalictrine chloride
|
Fungal
|
Infection
Metabolic Disease
|
|
Magnoflorine chloride (Magnoflorine chloride), an aporphine alkaloid found in Acoruscalamus, reduces the formation of C. albicans biofilm. Magnoflorine chloride has anti-fungal, anti-antidiabetic and anti-oxidative activity.
|
-
- HY-136204
-
-
- HY-B2114
-
|
Escin
|
Apoptosis
|
Inflammation/Immunology
Cancer
|
|
Escin, a natural mixture of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, can be used as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent.
|
-
- HY-N0184
-
-
- HY-N0720
-
-
- HY-N2014
-
|
Verbenalin
|
Others
|
Infection
Inflammation/Immunology
|
|
Verbenalin is Verbena glycoside, with anti-inflammatory, anti-fungal anti-virus activities. Verbenalin has a good effect on prostatitis. Verbenalin can reduce cerebral ischemia-reperfusion injury.
|
-
- HY-N6806
-
-
- HY-N0222
-
|
Avicularin
|
Others
|
Cancer
Inflammation/Immunology
|
|
Avicularin is a bio-active flavonoid from plants, anti-inflammatory, anti-allergic, anti-oxidant, hepatoprotective, and anti-tumor activities. Avicularin exhibits anti-inflammatory activity through the suppression of ERK signaling pathway in LPS-stimulated RAW 264.7 macrophage cells. Avicularin ameliorates human hepatocellular carcinoma via the regulation of NF κB (p65), COX 2 and PPAR γ activities.
|
-
- HY-N0155
-
|
Nobiletin
|
ROR
Reactive Oxygen Species
Apoptosis
Autophagy
|
Cancer
Inflammation/Immunology
Neurological Disease
|
|
Nobiletin is a poly-methoxylated flavone from the citrus peel that improves memory loss. Nobiletin is a retinoid acid receptor-related orphan receptors (RORs) agonist. Nobiletin can reduce reactive oxygen species (ROS) levels in differentiated C2C12 myotubes and has anti-inflammation and anti-cancer properties, including anti-angiogenesis, anti-proliferation, anti-metastasis and induced apoptosis.
|
-
- HY-N2604
-
|
Loureirin C
|
Others
|
Cancer
Infection
Metabolic Disease
Inflammation/Immunology
Neurological Disease
|
|
Loureirin C, isolated from "Dragon’s blood", which is a deep red resin obtained from a variety of plant sources. The resin extracted from stems of Dracaena cochinchinensis is one such source of “dragon’s blood”, has a reputation for facilitating blood circulation and dispersing blood stasis. The resin has anti-bacterial, anti-spasmodic, anti-inflammatory, analgesic, anti-diabetic, and anti-tumor activities.
|
-
- HY-N6258
-
|
Kahweol
|
AMPK
Apoptosis
|
Metabolic Disease
|
|
Kahweol is one of the consituents of the coffee from Coffea Arabica with anti-inflammatory anti-angiogenic, and anti-cancerous activities. Kahweol inhibits adipogenesis and increase glucose uptake by AMP-activated protein kinase (AMPK) activation. Kahweol induces apoptosis.
|
-
- HY-B2230
-
-
- HY-N0291
-
|
(±)-Norcantharidin
(±)-NCTD
|
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
(±)-Norcantharidin ((±)-NCTD) is a compound possessing anti-angiogenetic activity with potential use in anti-cancertherapy. (±)-Norcantharidin could prevent tumorigenesis by inhibiting cell proliferation, inducing apoptosis and the cell cycle arrest, and anti-angiogenic effects.
|
-
- HY-N6039
-
-
- HY-111757
-
-
- HY-N7083
-
-
- HY-N0184A
-
-
- HY-P1009
-
|
Z-YVAD-FMK
|
Caspase
|
Cancer
|
|
AA-Z-YVAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor with anti-inflammatory and anti-tumor activities.
|
-
- HY-B1888B
-
-
- HY-100711
-
|
Prodigiosin
Prodigiosine
|
Fungal
|
Cancer
Infection
|
|
Prodigiosin (Prodigiosine) is a secondary metabolite of Symbiotic bacteria, with anti-fungal and anti-cancer activity.
|
-
- HY-N0423
-
-
- HY-N2437
-
-
- HY-N0770
-
|
Isoliensinine
|
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
Isoliensinine is a bisbenzylisoquinoline alkaloid extracted from the seed embryo of Nelumbo nucifera, with anti-oxidant and anti-inflammatory and anti-cancer activities. Isoliensinine induces apoptosis in triple-negative human breast cancer cells.
|
-
- HY-P1539A
-
-
- HY-Y0892
-
-
- HY-N2490
-
|
Dehydrotrametenolic acid
|
Caspase
|
Cancer
Inflammation/Immunology
|
|
Dehydrotrametenolic acid is a sterol isolated from the sclerotium of Poria cocos. Dehydrotrametenolic acid induces apoptosis through caspase-3 pathway. Dehydrotrametenolic acid has anti-tumor activity, anti-inflammatory, anti-diabetic effects.
|
-
- HY-N1402
-
|
Oxysophoridine
Sophoridine N-oxide
|
Others
|
Inflammation/Immunology
|
|
Oxysophoridine (Sophoridine N-oxide) is a bioactive alkaloid extracted from the Sophora alopecuroides Linn. Oxysophoridine (Sophoridine N-oxide) shows anti inflammatory, anti oxidative stress and anti apoptosis effects.
|
-
- HY-N0334A
-
|
(+)-Magnoflorine iodide
Magnoflorine iodide; α-Magnoflorine iodide; Thalictrine iodide
|
Fungal
|
Infection
Metabolic Disease
|
|
(+)-Magnoflorine iodide (Magnoflorine iodide), an aporphine alkaloid found in Acoruscalamus, reduces the formation of C. albicans biofilm. (+)-Magnoflorine iodide has anti-fungal, anti-antidiabetic and anti-oxidative activity.
|
-
- HY-N0547
-
|
Nomilin
|
Others
|
Metabolic Disease
|
|
Nomilin is a limonoid compound obtained from the extracts of citrus fruits. Nomilin is an anti-obesity and anti-hyperglycemic agent .
|
-
- HY-N2035
-
-
- HY-N0718
-
-
- HY-N0472
-
-
- HY-104015
-
-
- HY-N0180
-
-
- HY-N0362
-
-
- HY-N5010
-
-
- HY-135190
-
-
- HY-N3848
-
-
- HY-N2357
-
-
- HY-N7030
-
|
5,7,3',4'-Tetramethoxyflavone
|
Others
|
Infection
|
|
5,7,3',4'-Tetramethoxyflavone, one of the major polymethoxyflavones (PMFs) isolated from M. exotica, possesses various bioactivities, including anti-fungal, anti-malarial, anti-mycobacterial, and anti-inflammatory activities. 5,7,3',4'-Tetramethoxyflavone exhibits chondroprotective activity by targeting β-catenin signaling.
|
-
- HY-N0405
-
|
Orientin
|
Others
|
Cancer
Neurological Disease
|
|
Orientin is a naturally occurring bioactive flavonoid that possesses diverse biological properties, including anti-inflammation, anti-oxidative, anti-tumor, and cardio protection. Orientin is a promising neuroprotective agent suitable for therapy for neuropathic pain.
|
-
- HY-106628
-
|
Sudoxicam
|
COX
|
Inflammation/Immunology
|
|
Sudoxicam is a reversible and orally active COX antagonist and a non-steroidal anti-inflammatory drug (NSAID) from the enol-carboxamide class. Sudoxicam has potent anti-inflammatory, anti-edema and antipyretic activity.
|
-
- HY-N1377
-
|
Nevadensin
|
Bacterial
|
Infection
Metabolic Disease
Inflammation/Immunology
|
|
Nevadensin is a naturally occurring selective inhibitor of human carboxylesterase 1 (hCE1) with an IC50 of 2.64 μM. Nevadensin has a variety of pharmacological effects such as anti-mycobacterium tuberculosis activities, antitussive, anti-inflammatory and anti-hypertensive.
|
-
- HY-N4137
-
-
- HY-N0628
-
-
- HY-N0400
-
-
- HY-N0073
-
-
- HY-117506
-
|
(S)-SBFI-26
|
FABP
|
Neurological Disease
|
|
(S)-SBFI-26 is the (S) enantiomer of SBFI-26, an anti-nociceptive agent binds to anandamide transporters FABP5 and FABP7. (S)-SBFI-26 has anti-nociceptive and anti-inflammatory effects.
|
-
- HY-N0108
-
|
Physcion
Parietin; Rheochrysidin
|
Bacterial
|
Cancer
Infection
Inflammation/Immunology
|
|
Physcion (Parietin) is an anthraquinone isolated from traditional Chinese medicine Radix et Rhizoma Rhei, acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively. Physcion (Parietin) exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects.
|
-
- HY-N0763
-
|
Angelicin
Isopsoralen
|
Apoptosis
Virus Protease
|
Cancer
|
|
Angelicin, a furocoumarin naturally occurring tricyclic aromatic compound, structurally related to psoralens, is reported to have anti-cancer, antiviral, anti-inflammatory activity.
|
-
- HY-N0114
-
|
Evodiamine
(+)-Evodiamine; d-Evodiamine
|
Others
|
Cancer
|
|
Evodiamine is an alkaloid isolated from the fruit of Evodia rutaecarpa Bentham with diverse biological activities including anti-inflammatory, anti-obesity, and antitumor.
|
-
- HY-N0512
-
|
Loganin
Loganoside
|
Apoptosis
|
Cancer
|
|
Loganin, a major iridoid glycoside obtained from Corni fructus, has been shown to have anti-inflammatory and anti-shock effects.
|
-
- HY-15097
-
-
- HY-N2343
-
-
- HY-N0100
-
-
- HY-100350
-
-
- HY-N0271
-
-
- HY-N6961
-
|
Lapachol
|
Bacterial
Fungal
Influenza Virus
Parasite
|
Cancer
Infection
Inflammation/Immunology
|
|
Lapachol is a naphthoquinone that was first isolated from Tabebuia avellanedae (Bignoniaceae). Lapachol shows anti-abscess, anti-ulcer, antileishmanial, anticarcinomic, antiedemic, anti-inflammatory, antimalarial, antiseptic, antitumor, antiviral, antibacterial, antifungal and pesticidal activities.
|
-
- HY-N7015
-
|
Zerumbone
|
HSV
|
Infection
|
|
Zerumbone is a monocyclic sesquiterpene compound isolated from the rhizomes of Zingiber zerumbet Smith. Zerumbone potently inhibits the activation of Epstein-Barr virus with an IC50 of 0.14 mM. Zerumbone has anti-cancer, antioxidant, anti-inflammatory and anti-proliferative activity.
|
-
- HY-N6884
-
-
- HY-N7046
-
|
Silybin B
|
Amyloid-β
|
Cancer
Neurological Disease
|
|
Silybin B, a flavonolignan separated from Silybum marianum, has anti-tumor activity. Silybin B is the most potent antifibrillogenic and anti-oligomeric component of silymarin and proposes it as a promising anti Alzheimer’s disease drug candidate.
|
-
- HY-N6714
-
|
Alternariol
|
Topoisomerase
|
Cancer
Infection
|
|
Alternariol is a mycotoxin produced by Alternaria species. AOH inhibits the catalytic activity of topoisomerase I and topoisomerase II enzymes. Alternariol exhibits a variety of therapeutic and biological properties such as phytotoxicity, cytotoxicity, anti-HIV, anti-cancer, and anti-microbial properties.
|
-
- HY-N0004
-
|
Oridonin
NSC-250682; Isodonol
|
Akt
Bacterial
|
Cancer
Infection
Inflammation/Immunology
|
|
Oridonin (NSC-250682), a diterpenoid isolated from Rabdosia rubescens, acts as an inhibitor of AKT, with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2; Oridonin possesses anti-tumor, anti-bacterial and anti-inflammatory effects.
|
-
- HY-N2127
-
|
Pinostrobin
|
Ser/Thr Protease
|
Inflammation/Immunology
|
|
Pinostrobin is a flavonoid can be found in many plants, and has anti-oxidant, anti-inflammatory, anti-cancer and neuroprotective properties. Pinostrobin is a potent PCSK9 inhibitor and inhibits the catalytic activity of PCSK9. Pinostrobin is a promising agent for cholesterol regulation and lipid management.
|
-
- HY-B1893
-
-
- HY-N1579
-
-
- HY-111621
-
|
DC661
|
Autophagy
Apoptosis
|
Cancer
|
|
DC661 is a potent palmitoyl-protein thioesterase 1 (PPT1) inhibitor, inhibits autophagy, and acts as an anti-lysosomal agent. Anti-cancer activity.
|
-
- HY-133153S
-
-
- HY-112920
-
|
TM-25659
|
Others
|
Metabolic Disease
|
|
TM-25659 is a transcriptional co-activator with PDZ-binding motif (TAZ) modulator. Anti-osteoporotic and anti-obesity activities.
|
-
- HY-12402
-
-
- HY-119500
-
-
- HY-114335
-
|
Triphala
|
NF-κB
Fungal
|
Cancer
Infection
Inflammation/Immunology
|
|
Triphala, an Ayurvedic polyherbal formulation comprising of equiproportional fruit parts of Terminalia chebula, Terminalia bellerica, and Phyllanthus emblica. Triphala inhibits NF-κB activation. Triphala exerts antifungal action. Anti-adipogenic, anti-inflammatory, and anti-neoplastic activities.
|
-
- HY-B0945
-
-
- HY-106859
-
-
- HY-U00046
-
-
- HY-B0994
-
-
- HY-107454
-
|
OSS_128167
|
Sirtuin
HBV
|
Cancer
Infection
Metabolic Disease
Inflammation/Immunology
|
|
OSS_128167 is a potent selective sirtuin 6 (SIRT6) inhibitor with IC50s of 89 μM, 1578 μM and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-HBV activity that inhibits HBV transcription and replication. OSS_128167 has anti-acncer, anti-inflammation and anti-viral effects.
|
-
- HY-N0580
-
|
Fraxetin
|
Apoptosis
|
|
|
Fraxetin is isolated from Cortex Fraxini. Fraxetin has antitumor, anti-oxidation effects and anti-inflammory effects. Fraxetin induces apoptosis.
|
-
- HY-133127
-
|
AR453588
|
Glucokinase
|
Metabolic Disease
|
|
AR453588 is a potent and orally bioavailable anti-diabetic glucokinase activator, with an EC50 of 42 nM. AR453588 shows anti-hyperglycemic activity.
|
-
- HY-N2192
-
-
- HY-133127A
-
-
- HY-N0484
-
|
Liensinine
|
Autophagy
Mitophagy
|
Cancer
Cardiovascular Disease
|
|
Liensinine is an autophagy/mitophagy inhibitor. Liensinine, a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn, has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc.
|
-
- HY-N4109
-
|
Decursinol
|
Others
|
Cancer
Inflammation/Immunology
|
|
Decursinol, isolated from the roots of Angelica gigas, possesses antinociceptive effect with orally bioavailability. Decursinol possesses anti-tumor and anti-metastasis activity.
|
-
- HY-N4116
-
|
Xanthyletin
|
Fungal
|
Cancer
Infection
|
|
Xanthyletin is a coumarin isolated from Citrus, with anti-tumor and anti-bacterial activities. Xanthyletin also inhibits symbiotic fungus cultivated by leaf-cutting ants.
|
-
- HY-N0575
-
-
- HY-N4068
-
|
Glucoraphanin
|
Reactive Oxygen Species
|
Cancer
|
|
Glucoraphanin, a natural glucosinolate found in cruciferous vegetable, is a stable precursor of the Nrf2 inducer sulforaphane, which possesses antioxidant, anti-inflammatory, and anti-carcinogenic effects.
|
-
- HY-N2994
-
-
- HY-N4322
-
-
- HY-117260
-
-
- HY-W013573
-
-
- HY-N5135
-
|
Liriopesides B
Nolinospiroside F
|
Others
|
Others
|
|
Liriopesides B (Nolinospiroside F) is a steroidal saponin isolated from Ophiopogon japonicas. Liriopesides B has anti-oxidative and anti-aging effects.
|
-
- HY-D0803
-
|
Thymoquinone
|
Others
|
Inflammation/Immunology
|
|
Thymoquinone is a nature product isolated from N. sativa. Thymoquinone possess antioxidant, anti-inflammatory, anti-cancer, antitumor activities and hepatoprotective properties.
|
-
- HY-14615
-
|
[6]-Gingerol
(S)-(+)-[6]Gingerol; 6-Gingerol
|
AMPK
Apoptosis
|
Cancer
|
|
[6]-Gingerol is an active compound isolated from Ginger (Zingiber officinale Rosc), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.
|
-
- HY-U00151
-
-
- HY-N0207
-
-
- HY-N0558
-
|
Alnustone
|
Others
|
Inflammation/Immunology
|
|
Alnustone, a non-phenolic diarylheptanoid found in herbs and spices, is a constituent of Curcuma xanthorrhiza. Alnustone displays anti-emetic and anti-inflammatory activities.
|
-
- HY-B0293
-
-
- HY-B0338A
-
-
- HY-U00229
-
-
- HY-B0089
-
-
- HY-B1118
-
-
- HY-B1137
-
-
- HY-N0176
-
-
- HY-101751
-
-
- HY-U00081
-
-
- HY-U00094
-
-
- HY-100142
-
-
- HY-N5003
-
-
- HY-N0799
-
|
Protodioscin
|
Endogenous Metabolite
|
Cancer
|
|
Protodioscin, a major steroidal saponin in dioscoreae rhizome, has been shown to exhibit multiple biological actions, such as anti-hyperlipidemia, anti-cancer, sexual effects and cardiovascular properties.
|
-
- HY-N0804
-
|
Narirutin
|
Bacterial
|
Inflammation/Immunology
|
|
Narirutin, one of the active constituents isolated from Citrus unshiu, has antioxidant and anti-inflammatory activities. Narirutin is a shikimate kinase inhibitor with anti-tubercular potency.
|
-
- HY-N3297
-
-
- HY-B1285
-
|
Dimercaprol
2,3-Dimercapto-1-propanol; Dithioglycerol
|
HIV
|
Infection
|
|
Dimercaprol (2,3-Dimercapto-1-propanol) is an anti-heavy metal-poisoning drug, which exhibits anti-HIV activity.
|
-
- HY-101907
-
-
- HY-14616
-
|
Shogaol
[6]-Shogaol; 6-Shogaol
|
Autophagy
|
Cancer
|
|
Shogaol ([6]-Shogaol), an active compound isolated from Ginger (Zingiber officinale Rosc), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.
|
-
- HY-N7292
-
-
- HY-N0120
-
|
(E/Z)-Polydatin
(E/Z)-Piceid
|
Others
|
Inflammation/Immunology
|
|
(E/Z)-Polydatin ((E/Z)-Piceid) is a monocrystalline compound originally isolated from the root and rhizome of Polygonum cuspidatum. (E/Z)-Polydatin has anti-platelet aggregation, anti-oxidative action of low-density lipoprotein (LDL), cardioprotective activity, anti-inflammatory and immune-regulating functions.
|
-
- HY-100775
-
|
Setogepram sodium salt
PBI-4050 sodium salt
|
GPR40
GPR84
|
Metabolic Disease
Inflammation/Immunology
|
|
Setogepram sodium salt (PBI-4050 sodium salt) acts as an orally active agonist for GPR40 and as an antagonist or inverse agonist for GPR84. Setogepram sodium salt decreases renal, liver and pancreatic fibrosis. Setogepram sodium salt exerts anti-fibrotic, anti-inflammatory and anti-proliferative actions.
|
-
- HY-N3963
-
-
- HY-122872
-
|
MKK7-COV-9
|
p38 MAPK
|
Cancer
|
|
MKK7-COV-9 is a potent and selective covalent inhibitor of MKK7 and targets a specific protein–protein interaction of MKK7. MKK7-COV-9 blocks primary B cell activation in response to LPS with an EC50 of 4.98 μM.
|
-
- HY-N0346A
-
-
- HY-N6880
-
|
Rabdosiin
(+)-Rabdosiin
|
Others
|
Infection
Inflammation/Immunology
|
|
Rabdosiin is a tetramer of caffeic acid isolated from the stem of Rabdosia japonica Hara. Rabdosiin possess anti-allergic activity, anti-HIV activity and inhibition on DNA topoisomerase.
|
-
- HY-N0474
-
-
- HY-N0370
-
|
Bergapten
5-Methoxypsoralen
|
Cytochrome P450
Autophagy
|
Cancer
|
|
Bergapten is a natural anti-inflammatory and anti-tumor agent isolated from bergamot essential oil, other citrus essential oils and grapefruit juice. Bergapten is inhibitory towards mouse and human CYP isoforms.
|
-
- HY-N6580
-
|
Ginsenoside Rg4
|
Bacterial
|
Infection
Metabolic Disease
Inflammation/Immunology
|
|
Ginsenoside Rg4 is a major protopanaxatriol type ginsenoside isolated from the leaves of Panax ginseng C. A. Meyer. The protopanaxatriol type ginsenosides (such as Ginsenoside Rg4) exhibits various biological activities including anti-septic, anti-diabetic, wound healing, immune-stimulatory, and anti-antioxidant activity.
|
-
- HY-B0348
-
-
- HY-B1203
-
-
- HY-B0338
-
-
- HY-100286
-
-
- HY-U00149
-
-
- HY-U00100
-
-
- HY-100146
-
-
- HY-B1047
-
-
- HY-B0578
-
-
- HY-B0089A
-
-
- HY-N0389
-
-
- HY-U00361
-
-
- HY-101573
-
-
- HY-101748
-
-
- HY-14934
-
-
- HY-N0812
-
-
- HY-B1245
-
-
- HY-A0158
-
-
- HY-13609
-
-
- HY-B0766
-
-
- HY-Y0073
-
|
4-Hydroxyacetophenone
P-hydroxyacetophenone
|
HBV
|
Infection
Inflammation/Immunology
|
|
4-Hydroxyacetophenone (P-hydroxyacetophenone) is a key hepatoprotective and choleretic compound in Artemisia capillaris and A. morrisonensis, also has an anti-hepatitis B virus effect and anti-inflammatory effect.
|
-
- HY-N1181
-
-
- HY-16278
-
|
Pradigastat
LCQ-908
|
Acyltransferase
|
Metabolic Disease
|
|
Pradigastat (LCQ-908) is a potent, selective and orally active diacylglycerol acyltransferase 1 (DGAT1) inhibitor. Pradigastat has anti-obesity and anti-diabetic effects.
|
-
- HY-N0205
-
|
Pulchinenoside C
Anemoside B4
|
Others
|
Cancer
|
|
Pulchinenoside C (Anemoside B4) is Pulsatilla koreana Nakai that have many numerous biological effects in vitro, including enhancing hypoglycemic, anti-tumor, neuroprotective and anti-angiogenic activity.
|
-
- HY-N6849
-
|
InteriotherinA
|
HIV
|
Infection
Metabolic Disease
|
|
Interiotherin A is a lignan with a dibenzocyclooctadiene skeleton isolated from Kadsura interior. Interiotherin A inhibits HIV replication to exhibit anti-HIV activity, it has a role as a metabolite and an anti-HIV agent.
|
-
- HY-N0192
-
|
Arbutin
β-Arbutin
|
Tyrosinase
|
Cancer
|
|
Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase in melanocytes, with Ki app values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents. Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties.
|
-
- HY-N1535
-
|
Ponicidin
Rubescensine B
|
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
Ponicidin (Rubescensine B) is a diterpenoid derived from Rabdosia rubescens, and exhibits immunoregulatory, anti-inflammatory, anti-viral and anti-cancer activity. Ponicidin (Rubescensine B) induces apoptosis of gastric carcinoma cell, decreases the phosphorylation of JAK2 and STAT3, and shows no effect on protein levels of JAK2 and STAT3.
|
-
- HY-N6049
-
-
- HY-N0363
-
|
(+)-Columbianetin
(S)-Columbianetin
|
Others
|
Infection
Inflammation/Immunology
|
|
(+)-Columbianetin is an isomer of Columbianetin. Columbianetin is a phytoalexin associated with celery (Apium graveolens) resistance to pathogens during storage. Columbianetin exhibits excellent anti-fungal and anti-inflammatory activity.
|
-
- HY-16126
-
-
- HY-113462
-
|
α-Carotene
|
Others
|
Cancer
|
|
α-Carotene, a precursor of vitamin A, is used as an anti-metastatic agent or as an adjuvant for anti-cancer drugs. α-Carotene is isolated from yellow-orange and dark-green vegetables.
|
-
- HY-N0773
-
|
Isovitexin
Saponaretin; Homovitexin
|
JNK
NF-κB
|
Inflammation/Immunology
|
|
Isovitexin is a flavonoid isolated from rice hulls of Oryza sativa, possesses anti-inflammatory and anti-oxidant activities; Isovitexin acts like a JNK1/2 inhibitor and inhibits the activation of NF-κB.
|
-
- HY-N2281
-
-
- HY-13077
-
-
- HY-101655
-
|
COX-2-IN-2
|
COX
|
Inflammation/Immunology
|
|
COX-2-IN-2 is a selective and inducible COX2 inhibitor with an IC50 of 0.24 μM. COX-2-IN-1 is an anti-inflammatory compound with anti-inflammatory and analgesic activities.
|
-
- HY-N0332
-
-
- HY-N0639
-
|
Punicalin
|
HBV
|
Infection
Inflammation/Immunology
|
|
Punicalin is a hydrolyzable tannin isolated from Punica granatum L. or the leaves of Terminalia catappa L.. Punicalin is a anti-hepatitis B virus (HBV) agent and has anti-inflammatory activity.
|
-
- HY-N6892
-
|
3'-O-Acetylhamaudol
|
Others
|
Cancer
|
|
3'-O-Acetylhamaudol, isolated from Angelica japonica roots, exhibits anti-tumor activity through dual actions, anti-angiogenesis and intestinal intraepithelial lymphocyte activation.
|
-
- HY-100775A
-
|
Setogepram
PBI-4050
|
GPR40
GPR84
|
Metabolic Disease
Inflammation/Immunology
|
|
Setogepram (PBI-4050) acts as an orally active agonist for GPR40 and as an antagonist or inverse agonist for GPR84. Setogepram (PBI-4050) decreases renal, liver and pancreatic fibrosis. Setogepram (PBI-4050) exerts anti-fibrotic, anti-inflammatory and anti-proliferative actions.
|
-
- HY-13516
-
|
Aloperine
|
Apoptosis
Autophagy
Filovirus
HIV
|
Cancer
Infection
Inflammation/Immunology
|
|
Aloperine is an alkaloid in sophora plants such as Sophora alopecuroides L, which has shown anti-cancer, anti-inflammatory and anti-virus properties.
Aloperine is widely used to treat patients with allergic contact dermatitis eczema and other skin inflammation in China. Aloperine induces apoptosis and autophagy in HL-60 cells.
|
-
- HY-N4042
-
|
Hirsutenone
|
PI3K
ERK
|
Cancer
Inflammation/Immunology
|
|
Hirsutenone is an active botanical diarylheptanoid present in Alnus species and exhibits many biological activities, including anti-inflammatory, anti-tumor promoting and anti-atopic dermatitis effects. Hirsutenone attenuates adipogenesis by binding directly to PI3K and ERK1 in a non-ATP competitive manner. Hirsutenone can be used for the study of obesity.
|
-
- HY-N0232
-
|
Psoralidin
|
COX
Lipoxygenase
Notch
Reactive Oxygen Species
Bacterial
|
Cancer
|
|
Psoralidin, isolated from the seed of Psoralea corylifolia, is a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation.Anti-cancer, anti-bacterial, and anti-inflammatory properties. Psoralidin significantly downregulates NOTCH1 signaling. Psoralidin also greatly induces ROS generation.
|
-
- HY-N3187
-
-
- HY-17476
-
-
- HY-B1015
-
-
- HY-17490
-
-
- HY-U00258
-
-
- HY-13570A
-
-
- HY-P0052A
-
-
- HY-10249A
-
-
- HY-B0288B
-
-
- HY-N0885
-
-
- HY-109098
-
-
- HY-B0288A
-
-
- HY-B0357
-
-
- HY-N0213
-
-
- HY-13570
-
-
- HY-18199
-
-
- HY-18981
-
-
- HY-13025
-
-
- HY-101694
-
-
- HY-101743
-
-
- HY-16349
-
-
- HY-P0052
-
-
- HY-14937
-
-
- HY-B0376
-
|
Mecarbinate
Dimecarbin; Dimecarbine; Dimekarbin
|
HCV
|
Infection
|
|
Mecarbinate is an anti-hepatitis C virus (HCV) agent.
|
-
- HY-113162
-
-
- HY-N0261
-
|
Aurantio-obtusin
|
Others
|
Inflammation/Immunology
Cardiovascular Disease
|
|
Aurantio-obtusin is an anthraquinone isolated from Semen Cassiae, with anti-Inflammatory, anti-oxidative, anti-coagulating and anti-hypertension activities. Aurantio-obtusin relaxes systemic arteries through endothelial PI3K/AKT/eNOS-dependent signaling pathway in rats, thus acts as a new potential vasodilator. Aurantio-obtusin inhibits allergic responses in IgE-mediated mast cells and anaphylactic models and is potential for treatment for allergy-related diseases.
|
-
- HY-N1438
-
|
Hydroxygenkwanin
7-O-Methylluteolin
|
Others
|
Cancer
|
|
Hydroxygenkwanin (7-O-Methylluteolin), a natural flavonoid compound, is one of the main components of Lilac Daphne. Hydroxygenkwanin has anti-oxidant ability, anti-glioma ability and anticancer effect.
|
-
- HY-N6074
-
|
Soyasapogenol B
|
Autophagy
Apoptosis
|
Cancer
|
|
Soyasapogenol B, an ingredient of soybean, exerts anti-proliferative, anti-metastatic activities. Soyasapogenol B triggers endoplasmic reticulum stress, which mediates apoptosis and autophagy in colorectal cancer.
|
-
- HY-N0363A
-
|
(+)-Columbianetin acetate
(S)-Columbianetin acetate
|
Others
|
Infection
Inflammation/Immunology
|
|
(S)-Columbianetin acetate is an isomer of Columbianetin. Columbianetin is a phytoalexin associated with celery (Apium graveolens) resistance to pathogens during storage. Columbianetin exhibits excellent anti-fungal and anti-inflammatory activity.
|
-
- HY-104075
-
|
R916562
|
TAM Receptor
VEGFR
|
Cancer
|
|
R916562 is an orally active and selective Axl/VEGF-R2 inhibitor with IC50s of 136 nM and 24 nM, respectively. R916562 has anti-angiogenesis and anti-metastasis.
|
-
- HY-N5025
-
|
Bullatine A
|
P2X Receptor
|
Cancer
Inflammation/Immunology
|
|
Bullatine A, a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. Bullatine A is a potent P2X7 antagonist, inhibits ATP-induced cell death/apoptosis and P2X receptor-mediated inflammatory responses. Bullatine A attenuates pain hypersensitivity, regardless of the pain models employed.
|
-
- HY-N7255
-
|
Cycloartenol
|
p38 MAPK
Apoptosis
|
Cancer
|
|
Cycloartenol, a phytosterol compound, is one of the key precusor substances for biosynthesis of numerous sterol compounds. Cycloartenol inhibits the migration of glioma cells and suppresses the phosphorylation of the p38 MAP kinase. Cycloartenol has a variety of pharmacological activities such as anti-inflammatory, anti-tumor, antioxidant, antibiosis and anti-alzheimer's disease. Cycloartenol also plays an important role in the process of plant growth and development.
|
-
- HY-N6246
-
|
Asperulosidic Acid
|
NF-κB
ERK
|
Cancer
Inflammation/Immunology
|
|
Asperulosidic Acid (ASPA), a bioactive iridoid glycoside, is extracted from the herbs of Hedyotis diffusa Willd. Asperulosidic Acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities.
ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the NF-κB and mitogen-activated protein kinase (MAPK) signaling pathways.
|
-
- HY-117319
-
-
- HY-106541
-
|
Neticonazole
|
Fungal
|
Cancer
Infection
|
|
Neticonazole is an imidazole derivative and a potent and long-acting antifungal agent. Neticonazole is also an orally active exosome biogenesis and secretion inhibitor. Neticonazole has anti-infection and anti-cancer effects.
|
-
- HY-18303
-
|
AMG-47a
|
Src
|
Inflammation/Immunology
|
|
AMG-47a is a potent inhibitor of Lck and T cell proliferation; exhibits anti-inflammatory activity (ED50 = 11 mg/kg) in the anti-CD3 induced production of IL-2 in mice.
|
-
- HY-N4288
-
-
- HY-128365
-
|
Neticonazole hydrochloride
|
Fungal
|
Cancer
Infection
|
|
Neticonazole hydrochloride is an imidazole derivative and a potent and long-acting antifungal agent. Neticonazole hydrochloride is also an orally active exosome biogenesis and secretion inhibitor. Neticonazole hydrochloride has anti-infection and anti-cancer effects.
|
-
- HY-N2303
-
-
- HY-N0731
-
-
- HY-128695
-
-
- HY-15721
-
-
- HY-N0156
-
-
- HY-B2044
-
-
- HY-B0336
-
-
- HY-13727
-
-
- HY-13571
-
-
- HY-U00350
-
-
- HY-16398
-
-
- HY-14812
-
-
- HY-B0483
-
-
- HY-B0645
-
-
- HY-U00043
-
-
- HY-101754
-
-
- HY-101597
-
-
- HY-15385
-
|
Imexon
BM 06002
|
Others
|
Cancer
|
|
Imexon (BM 06002) is an iminopyrrolidone aziridine with anti-cancer activity.
|
-
- HY-N0714A
-
-
- HY-B1383
-
-
- HY-121054
-
|
Chalcone
|
Bacterial
|
Cancer
Inflammation/Immunology
|
|
Chalcone is isolated from Glycyrrhizae inflata and used to synthesize chalcone derivatives. Chalcone derivatives possess varied biological and pharmacological activity, including anti-inflammatory, antioxidative, antibacterial, anticancer, and anti-parasitic activities.
|
-
- HY-N0808
-
-
- HY-A0203
-
|
Pentosan Polysulfate
|
HIV
|
Infection
Inflammation/Immunology
|
|
Pentosan Polysulfate is an orally bioavailable medication with anti-inflammatory and pro-chondrogenic properties. Pentosan Polysulfate also is a potent and selective anti-HIV agent. Pentosan Polysulfate is used for the treatment of interstitial cystitis.
|
-
- HY-101021
-
|
Ascochlorin
Ilicicolin D
|
STAT
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
Ascochlorin (Ilicicolin D), an isoprenoid antibiotic, mediates its anti-tumor effects predominantly through the suppression of STAT3 signaling cascade. Ascochlorin induces apoptosis. Anti-inflammatory activity.
|
-
- HY-106579
-
|
Tiaprofenic acid
|
COX
|
Inflammation/Immunology
|
|
Tiaprofenic acid is an orally active nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic potency. Tiaprofenic acid inhibits prostaglandin synthesis by suppressing cyclo-oxygenase (COX). Tiaprofenic acid can be used in the treatment of rheumatic diseases.
|
-
- HY-N4187
-
-
- HY-128463
-
-
- HY-14621
-
|
Zingerone
Vanillylacetone; Gingerone
|
NF-κB
|
Cancer
Metabolic Disease
Inflammation/Immunology
|
|
Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrhoeic, antispasmodic and anti-tumor properties. Zingerone alleviates oxidative stress and inflammation, down-regulates NF-κB mediated signaling pathways. Zingerone acts as an anti-mitotic agent, and inhibits the growth of neuroblastoma cells.
|
-
- HY-P0256
-
-
- HY-13696
-
-
- HY-N2477
-
|
Taraxerol
|
Apoptosis
NF-κB
|
Cancer
Inflammation/Immunology
|
|
Taraxerol is isolated from Abroma augusta L, and has anti-inflammtory and anti-cancer effects. Taraxerol attenuates acute inlammation through inhibition of NF-κB signaling pathway. Taraxerol induces cell apoptosis.
|
-
- HY-108472
-
-
- HY-N0063
-
|
Punicalagin
|
HBV
|
Cancer
Infection
Metabolic Disease
|
|
Punicalagin is a polyphenol ingredient isolated from Pomegranate (Punica granatum L.) or the leaves of Terminalia catappa L.. Punicalagin is a anti-hepatitis B virus (HBV) agent and has antioxidant, anti-inflammatory, and anticancer effects.
|
-
- HY-N2080
-
|
Songorine
|
GABA Receptor
|
Cancer
|
|
Songorine is a diterpenoid alkaloid isolated from the genus Aconitum. Songorine is a GABAA receptor antagonist in rat brain and has anti cancer, antiarrhythmic and anti-inflammatory activities. Songorine has the potential for the treatment of Epithelial ovarian cancer (EOC).
|
-
- HY-N4084
-
|
Thonningianin A
|
Apoptosis
|
Cancer
|
|
Thonningianin A, an ellagitannin, is isolated from the methanolic extract of the African medicinal herb, Thonningia sanguinea. The antioxidant properties of Th A involve radical scavenging, anti-superoxide formation and metal chelation. Anti-cancer activities.
|
-
- HY-N2000
-
|
Bellidifolin
|
HIV
|
Cancer
Infection
Inflammation/Immunology
|
|
Bellidifolin is a xanthone isolated from the stems of Swertia punicea, with hepatoprotective, hypoglycemic, anti-oxidation, anti-inflammatory and antitumor activities. Bellidifolin also acts as a viral protein R (Vpr) inhibitor.
|
-
- HY-N0439
-
-
- HY-N1954
-
|
Protostemonine
|
Others
|
Inflammation/Immunology
|
|
Protostemonine is an active alkaloid mainly isolated from the roots of Stemona sesslifolia, with anti-inflammatory activity. Protostemonine has anti-inflammatory effects on asthma and gram-negative bacteria-induced acute lung injury.
|
-
- HY-130234
-
|
SP-8356
|
NF-κB
Apoptosis
|
Cancer
Cardiovascular Disease
|
|
SP-8356, an anti-inflammatory synthetic verbenone derivative, is a potent, orally active cluster of differentiation 147 (CD147) inhibitor. SP-8356 inhibits CD147-cyclophilin A (CypA) interaction and reduces MMP-9 activity. SP-8356 exerts anti-breast cancer effects by inhibiting NF-κB signaling. Anti-atherosclerotic effects.
|
-
- HY-N0485
-
|
Liensinine Diperchlorate
|
Autophagy
Mitophagy
|
Cardiovascular Disease
|
|
Liensinine Diperchlorate is a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn. Liensinine Diperchlorate inhibits late-stage autophagy/mitophagy through blocking autophagosome-lysosome fusion. Liensinine Diperchlorate has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc.
|
-
- HY-10582
-
-
- HY-B0421
-
-
- HY-N4312
-
-
- HY-N0212
-
|
Peimine
Verticine; Dihydroisoimperialine
|
Others
|
Inflammation/Immunology
|
|
Peimine(Dihydroisoimperialine; Verticine) is a natural compound with good anti-inflammatory effects in vivo.
|
-
- HY-B1138
-
-
- HY-N0796
-
-
- HY-B0779
-
-
- HY-19085
-
-
- HY-B2232
-
-
- HY-128689
-
-
- HY-103672
-
-
- HY-B0350A
-
-
- HY-B0248
-
-
- HY-U00406
-
-
- HY-14857
-
-
- HY-B0600
-
-
- HY-P0183
-
-
- HY-N0725
-
-
- HY-B1900
-
-
- HY-13727A
-
-
- HY-B0811
-
-
- HY-14916
-
-
- HY-B0634
-
-
- HY-N0103
-
|
Sophocarpine
|
Autophagy
Apoptosis
PI3K
Akt
Influenza Virus
|
Cancer
Infection
Inflammation/Immunology
|
|
Sophocarpine is one of the significant alkaloid extracted from the traditional herb medicine Sophora flavescens which has many pharmacological properties such as anti-virus, anti-tumor, anti-inflammatory. Sophocarpine significantly inhibits the growth of gastric cancer (GC) cells through multiple mechanisms such as induction of autophagy, activation of cell apoptosis and down-regulation of cell survival PI3K/AKT signaling pathway. Sophocarpine has been demonstrated to have anti-tumor activity in various cancer cells, including hepatocellular carcinoma, prostate cancer and colorectal cancer.
|
-
- HY-N0408
-
|
Picroside II
|
NF-κB
Reactive Oxygen Species
Apoptosis
Influenza Virus
|
Cancer
Infection
Inflammation/Immunology
Neurological Disease
|
|
Picroside II, an iridoid compound extracted from Picrorhiza, exhibits anti-inflammatory and anti-apoptotic activities.
picroside II alleviates the inflammatory response in sepsis and enhances immune function by inhibiting the activation of NLRP3 inflammasome and NF-κB pathways.
Picroside II is an antioxidant, exhibits a significant neuroprotective effect through reducing ROS production and protects the blood-brain barrier (BBB) after cerebral ischemia-reperfusion (CI/R) injury. Picroside II has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities.
|
-
- HY-W016586
-
|
Acivicin
AT-125; U-42126
|
Parasite
|
Cancer
Infection
|
|
Acivicin (AT-125), a natural product produced by Streptomyces sviceus is a γ−glutamyl transpeptidase (GGT) inhibitor. Acivicin can across the blood-brain barrier and has anti-cancer, anti-parasitic properties.
|
-
- HY-N7016A
-
-
- HY-N3005
-
|
Britannin
|
Apoptosis
Autophagy
|
Cancer
Inflammation/Immunology
|
|
Britannin, isolated from Inula aucheriana, is a sesquiterpene lactone. Britannin induces apoptosis and autophagy by activating AMPK regulated by ROS in liver cancer cells. Britannin has anti-proliferative and anti-inflammatory activities.
|
-
- HY-W015007
-
|
Metyrosine
|
COX
|
Cardiovascular Disease
|
|
Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity. Metyrosine is a very effective agent for blood pressure control.
|
-
- HY-111950
-
|
(-)-Ibuprofenamide
(R)-Ibuprofenamide
|
Others
|
Inflammation/Immunology
|
|
(-)-Ibuprofenamide is an amide prodrug of Ibuprofen with anti-inflammatory activity. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively.
|
-
- HY-N1984
-
|
Artemisic acid
Qing Hao acid; Artemisinic acid; Arteannuic acid
|
Bacterial
|
Cancer
Infection
Metabolic Disease
Inflammation/Immunology
|
|
Artemisinic acid (Qing Hao acid), an amorphane sesquiterpene isolated from Artemisia annua L., possesses a variety of pharmacological activity, such as antimalarial activity, anti-tumor activity, antipyretic effect, antibacterial activity, allelopathy effect and anti-adipogenesis effect.
|
-
- HY-N2010
-
-
- HY-N7016
-
-
- HY-N1934
-
-
- HY-N0295
-
|
Protocatechualdehyde
Catechaldehyde; Protocatechuic aldehyde; Rancinamycin IV
|
Reactive Oxygen Species
Bacterial
|
Cancer
Infection
|
|
Protocatechualdehyde (Catechaldehyde), a natural polyphenol compound isolated from the roots of radix Salviae Miltiorrhizae, is associated with a wide variety of biological activities and has been widely used in medicine as an antioxidant, anti-aging, an antibacterial and anti-inflammatory agent.
|
-
- HY-19827
-
|
Aeroplysinin 1
(+)-Aeroplysinin-1
|
Bacterial
HIV
Apoptosis
|
Cancer
Infection
|
|
Aeroplysinin 1 ((+)-Aeroplysinin-1), a secondary metabolite isolated from marine sponges, shows potent antibiotic effects on Gram-positive bacteria and exerts antiviral activity against HIV-1 (IC50=14.6 μM). Aeroplysinin 1 has anti-inflammatory, anti-angiogenic and anti-tumor activities. Aeroplysinin 1 induces apoptosis in endothelial cells.
|
-
- HY-N4097
-
|
Incensole
|
Others
|
Neurological Disease
|
|
Incensole, a 14-membered diterpenoid, is isolated from both essential oils and resins of frankincense. Incensole has shown anti-inflammatory and anti-depression activities due to their ability to activate ion channels in the brain to alleviate anxiety or depression.
|
-
- HY-A0203A
-
|
Pentosan Polysulfate Sodium
|
HIV
|
Infection
Inflammation/Immunology
|
|
Pentosan Polysulfate Sodium is an orally bioavailable, semi-synthetic medication with anti-inflammatory and pro-chondrogenic properties. Pentosan Polysulfate Sodium also is a potent and selective anti-HIV agent. Pentosan Polysulfate Sodium is used for the treatment of interstitial cystitis.
|
-
- HY-W010271
-
-
- HY-N0162
-
|
Luteolin
Luteoline; Luteolol; Digitoflavone
|
Apoptosis
Autophagy
Endogenous Metabolite
|
Cancer
Inflammation/Immunology
|
|
Luteolin (Luteolol) is a flavanoid with anti-inflammatory, anti-cancer properties, including the induction of apoptosis and cell cycle arrest, and the inhibition of metastasis and angiogenesis, in several cancer cell lines, including human non-small lung cancer cells.
|
-
- HY-N1581
-
|
Quassin
Nigakilactone D
|
Parasite
|
Infection
Endocrinology
|
|
Quassin (Nigakilactone D) is a bioactive triterpenoid from stem bark extract of Quassia amara. Quassin inhibits P. falciparum with an IC50 of 0.15 μM. Quassin possesses reversible antifertility, anti-estrogenic and anti-plasmodial activity.
|
-
- HY-N0589
-
-
- HY-16172
-
|
DMAPT
Dimethylamino Parthenolide
|
NF-κB
|
Cancer
|
|
DMAPT (Dimethylamino Parthenolide), a water soluble analogue of Parthenolide (PTL), is an oral active NF-κB inhibitor, with a LD50 of 1.7 μM for cell population in AML cells. Has potential anti-cancer and anti-metastatic effect.
|
-
- HY-135408
-
-
- HY-N1353
-
-
- HY-P0256A
-
-
- HY-115550
-
-
- HY-B1322
-
-
- HY-W013478
-
-
- HY-13600
-
-
- HY-U00344
-
-
- HY-U00345
-
-
- HY-B0105A
-
-
- HY-N6941
-
-
- HY-16509
-
-
- HY-N2123
-
-
- HY-17484
-
-
- HY-B0370
-
-
- HY-101488
-
-
- HY-U00337
-
-
- HY-101706
-
-
- HY-U00169
-
-
- HY-B0270
-
-
- HY-N0103A
-
|
Sophocarpine monohydrate
|
Autophagy
Apoptosis
PI3K
Akt
Influenza Virus
|
Cancer
Infection
Inflammation/Immunology
|
|
Sophocarpine (monohydrate) is one of the significant alkaloid extracted from the traditional herb medicine Sophora flavescens which has many pharmacological properties such as anti-virus, anti-tumor, anti-inflammatory. Sophocarpine (monohydrate) significantly inhibits the growth of gastric cancer (GC) cells through multiple mechanisms such as induction of autophagy, activation of cell apoptosis and down-regulation of cell survival PI3K/AKT signaling pathway. Sophocarpine (monohydrate) has been demonstrated to have anti-tumor activity in various cancer cells, including hepatocellular carcinoma, prostate cancer and colorectal cancer.
|
-
- HY-N0677
-
-
- HY-N2521
-
|
Tetramethylcurcumin
FLLL31
|
STAT
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
Tetramethylcurcumin (FLLL31), derived from curcumin, specifically suppresses the phosphorylation of STAT3 by binding selectively to Janus kinase 2 and the STAT3 Src homology-2 domain. Tetramethylcurcumin exhibits anti-inflammatory and anti-cancer effects.
|
-
- HY-N0188
-
|
Esculin
|
p38 MAPK
|
Inflammation/Immunology
Cancer
|
|
Esculin, a fluorescent coumarin glucoside, is an active ingredient of ash bark. Esculin ameliorates cognitive impairment in experimental diabetic nephropathy (DN), and exerts anti‑oxidative stress and anti‑inflammatory effects, via the MAPK signaling pathway.
|
-
- HY-N0705
-
-
- HY-N0211
-
|
Cyasterone
|
EGFR
|
Cancer
|
|
Cyasterone, a natural EGFR inhibitor, mainly isolated from Ajuga decumbens Thunb (Labiatae). Cyasterone manifests anti-proliferation effect by induced apoptosis and cell cycle arrests. Cyasterone may serves as a therapeutic anti-tumor agent against human tumors.
|
-
- HY-16561
-
-
- HY-129943
-
|
Benzothiohydrazide
|
Bacterial
|
Infection
|
|
Benzothiohydrazide is an analogue of anti–tubercular agent Isoniazid. Benzothiohydrazide exhibits anti–tubercular activity, with MICs of 132 μM and 264 μM for M. tuberculosis wild type (H37Rv) and clinical mutant strains (IC1 and IC2).
|
-
- HY-W018800
-
-
- HY-N2920
-
|
β-Amyrenonol
11-Oxo-β-amyrin
|
Cytochrome P450
|
Cancer
Inflammation/Immunology
|
|
β-Amyrenonol (11-Oxo-β-amyrin), an oleanolic-type triterpenoid in licorice roots, is a precursor of Glycyrrhetinic acid. β-Amyrenonol has anti-proliferative and anti-inflammatory activities, and β-Amyrenonol could function as the skeleton for the synthesis of many triterpenoids.
|
-
- HY-15273
-
-
- HY-N4233
-
|
Bisabolangelone
|
p38 MAPK
|
Inflammation/Immunology
|
|
Bisabolangelone, a sesquiterpene derivative, is isolated from the roots of Osterici Radix. Bisabolangelone possesses anti-inflammatory properties, which inhibits LPS-stimulated inflammation through the blocking of NF-kappaB and MAPK pathways in macrophages. Bisabolangelone has anti-ulcer activities.
|
-
- HY-N0677B
-
-
- HY-N0526
-
|
2"-O-Galloylhyperin
|
Others
|
Inflammation/Immunology
|
|
2"-O-Galloylhyperin, an active compound isolated from Pyrola incarnate Fisch., possesses anti-oxidative and anti-inflammatory activities. 2"-O-Galloylhyperin has hepatoprotective effect against oxidative stress-induced liver damage.
|
-
- HY-135646
-
|
Eleutheroside B1
|
Influenza Virus
|
Infection
Inflammation/Immunology
|
|
Eleutheroside B1, a coumarin compound, has a wide spectrum of anti-human influenza virus efficacy, with an IC50 value of 64-125 µg/ml. Eleutheroside B1 mediates its anti-influenza activity through POLR2A and N-glycosylation. Eleutheroside B1 inhibits the mRNA expression of several chemokine genes and the influenza nucleoprotein (NP) gene, and exhibits low cytotoxicity. Antiviral and anti-inflammatory activities.
|
-
- HY-B0482
-
|
Acemetacin
TVX 1322
|
COX
|
Inflammation/Immunology
|
|
Acemetacin (TVX 1322) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.
|
-
- HY-14586
-
|
Irosustat
STX64; BN83495; 667-Coumate
|
Others
|
Cancer
|
|
Irosustat is a potent steroid sulfatase inhibitor, with an IC50 of 8 nM, and exhibits anti-breast cancer activity.
|
-
- HY-N6898
-
-
- HY-N0559
-
-
- HY-B1718
-
-
- HY-101639A
-
-
- HY-14947
-
|
Balamapimod
MKI 833
|
MEK
|
Cancer
|
|
Balamapimod (MKI 833) is a reversible Ras/Raf/MEK inhibitor with potential anti-tumor activity.
|
-
- HY-12053A
-
-
- HY-P1539
-
-
- HY-B2113
-
-
- HY-B0758
-
-
- HY-N0056
-
-
- HY-N3472
-
-
- HY-N0351
-
-
- HY-N6087
-
-
- HY-B1487
-
-
- HY-N0235
-
-
- HY-B1013
-
-
- HY-N0813
-
-
- HY-U00379
-
|
LM985
|
Others
|
Cancer
|
|
LM985 is one of a series of compounds based on the flavone ring structure, with anti-tumor activities.
|
-
- HY-16397A
-
-
- HY-17361
-
-
- HY-101639
-
-
- HY-U00048
-
-
- HY-108986
-
-
- HY-N2352A
-
-
- HY-N6988
-
|
Cimigenol
|
Others
|
Cancer
|
|
Cimigenol is an active compound isolated from Cimicifuga, with potent anti-tumor activity.
|
-
- HY-N2271
-
-
- HY-113450
-
-
- HY-B0386
-
-
- HY-B0104
-
|
Glimepiride
Glimperide; HOE-490
|
Others
|
Metabolic Disease
|
|
Glimepiride (Glimperide) is a medium-to-long acting sulfonylurea anti-diabetic compound with an ED50 of 182 μg/kg.
|
-
- HY-12053
-
-
- HY-128346
-
|
PQM130
|
Amyloid-β
|
Neurological Disease
|
|
PQM130, a Feruloyl-Donepezil Hybrid compound with brain penatration, is a multitarget drug candidate against the neurotoxicity induced by Aβ1-42 oligomer (AβO) and shows anti-inflammatory activity. PQM130 acts as a neuroprotective compound for anti-AD drug development.
|
-
- HY-N4264
-
|
Vinaginsenoside R3
|
Others
|
Inflammation/Immunology
|
|
Vinaginsenoside R3 is a saponin composition of roots of Panax ginseng. Ginsengs have been not only used as therapeutic agents with tonic, sedative, anti-fatigue, and anti-gastric ulcer effect but also marketed as dietary supplements and raw materials of health food.
|
-
- HY-15234
-
|
Fluticasone furoate
|
Glucocorticoid Receptor
|
Inflammation/Immunology
|
|
Fluticasone furoate is a topical, intranasal, enhanced-affinity synthetic trifluorinated corticosteroid with a Kd of 0.3 nM. Fluticasone furoate has potent anti-inflamatory and anti-asthmatic activity, and low systemic exposure. Fluticasone furoate has the potential for allergic rhinitis treatment.
|
-
- HY-N0328
-
-
- HY-N6641
-
|
Monascin
|
Others
|
Cancer
Inflammation/Immunology
|
|
Monascin is a kind of azaphilonoid pigments extracted from Monascus pilosus-fermented rice (red-mold rice). Monascin also exhibits anti-tumor-initiating activity and anti-inflammatory activity with oral administration. Monascin inhibits the activation of NOR 1 (an NO donor).
|
-
- HY-N0829
-
|
Shionone
|
Others
|
Inflammation/Immunology
|
|
Shionone is the major triterpenoid isolated from Aster tataricus, has anti-tussive, anti-inflammatory activities. Shionone possesses a unique six-membered tetracyclic skeleton and 3-oxo-4-monomethyl structure.
|
-
- HY-105231
-
|
Bryostatin 1
|
PKC
HIV
|
Cancer
Infection
Inflammation/Immunology
Neurological Disease
|
|
Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a potent and central nervous system (CNS)-permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain of Munc13-1 and the full-length Munc13-1 protein with Kis of 8.07 nM and 0.45 nM, respectively. Bryostatin 1 has anti-cancer, anti-inflammatory, neuroprotective, anti-HIV-1 infection properties.
|
-
- HY-107569
-
|
Garcinol
|
AChE
Histone Acetyltransferase
Apoptosis
Endogenous Metabolite
|
Cancer
Inflammation/Immunology
|
|
Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 0.66 µM and 7.39 µM, respectively. Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity.
|
-
- HY-N0166
-
-
- HY-N7031
-
|
(±)-Vasicine
(±)-Peganine
|
Proton Pump
|
Inflammation/Immunology
|
|
(±)-Vasicine is the racemate of Vasicine. Vasicine (Peganine), isolated from Peganum harmala seeds, significantly inhibits H +-K +-ATPase activity in vitro with an IC50 of 73.47 μg/mL. Anti-ulcer activity. Vasicine shows significant anti-secretory, antioxidant and cytoprotective effect.
|
-
- HY-N2795
-
|
9-Hydroxycalabaxanthone
Xanthone I
|
Parasite
Bacterial
|
Infection
|
|
9-Hydroxycalabaxanthone (Xanthone I) is a known xanthone isolated from Garcinia mangostana Linn. 9-Hydroxycalabaxanthone has quorum-sensing inhibitory, anti-microbial, and anti-malarial activities (IC50=1.2-1.5 µM).
|
-
- HY-N3417
-
|
Kongensin A
|
HSP
RIP kinase
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
Kongensin A is a natural product isolated from Croton kongensis. Kongensin A is an effective, covalent HSP90 inhibitor that blocks RIP3-dependent necroptosishas. Kongensin A is a potent necroptosis inhibitor and an apoptosis inducer. Kongensin A has potential anti-necroptosis and anti-inflammation applications.
|
-
- HY-111783
-
-
- HY-N0058
-
-
- HY-109197
-
-
- HY-B0109
-
-
- HY-130959
-
-
- HY-16496
-
-
- HY-B1179
-
-
- HY-19556
-
-
- HY-128937
-
-
- HY-B0481
-
|
Miglitol
BAY1099; BAY-m1099
|
Others
|
Metabolic Disease
|
|
Miglitol is an oral anti-diabetic drug that acts by inhibiting the ability of the patient to breakdown complex carbohydrates into glucose.
|
-
- HY-109018
-
-
- HY-B0641
-
-
- HY-N0662
-
-
- HY-103128
-
-
- HY-B0174
-
-
- HY-N0404
-
-
- HY-B0476
-
-
- HY-112091
-
-
- HY-130960
-
-
- HY-76225
-
-
- HY-B1104
-
-
- HY-N5008
-
-
- HY-N2151
-
-
- HY-N4124
-
-
- HY-111354
-
-
- HY-101581
-
|
Bucloxic acid
804CB; Bucloxonic acid; Esfar
|
Others
|
Inflammation/Immunology
|
|
Bucloxic acid is an anti-inflammatory pyrrazole derivative. Bucloxic acid can be used in the treatment of chronic glomerular nephropathies.
|
-
- HY-N2152
-
-
- HY-N2290
-
-
- HY-N2154
-
-
- HY-32343
-
-
- HY-111761
-
|
DIQ3
|
Others
|
Cancer
|
|
DIQ3 is a potent anti-cancer agent, nontoxic to normal human cell lines.
|
-
- HY-N2030
-
-
- HY-N4272
-
|
Protodeltonin
|
Others
|
Cancer
|
|
Protodeltonin is a steroidal saponin from Dioscorea zingiberensis Wright, with anti-proliferation activity.
|
-
- HY-N2071
-
|
Cedrol
(+)-Cedrol; α-Cedrol
|
Cytochrome P450
Fungal
|
Infection
Inflammation/Immunology
Cancer
|
|
Cedrol is a bioactive sesquiterpene, a potent competitive inhibitor of cytochrome P-450 (CYP) enzymes. Cedrol inhibits CYP2B6-mediated bupropion hydroxylase and CYP3A4-mediated midazolam hydroxylation with Ki of 0.9 μM and 3.4 μM, respectively. Cedrol also has weak inhibitory effect on CYP2C8, CYP2C9, and CYP2C19 enzymes. Cedrol is found in cedar essential oil and poetesses anti-septic, anti-inflammatory, anti-spasmodic, tonic, astringent, diuretic, sedative, insecticidal, and anti-fungal activities.
|
-
- HY-N0368
-
|
Linalool
|
iGluR
Apoptosis
Endogenous Metabolite
|
Cancer
Cardiovascular Disease
|
|
Linalool is natural monoterpene in essential olis of coriander, acts as a competitive antagonist of Nmethyl d-aspartate (NMDA) receptor, with anti-tumor, anti-cardiotoxicity activity.Linalool is a PPARα ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome.
|
-
- HY-114300
-
|
DSP-0565
|
Others
|
Neurological Disease
|
|
DSP-0565 (compound 17a) is a strong, broad-spectrum anti-epileptic drug (AED) candidate with unique GABAergic function. DSP-0565 shows anti-convulsant activity in various models (scPTZ, MES, 6 Hz and amygdala kindling) with good safety margin.
|
-
- HY-N0677A
-
|
Kalii Dehydrographolidi Succinas
Potassium dehydroandrographolide succinate
|
Others
|
Infection
Inflammation/Immunology
Cancer
|
|
Kalii Dehydrographolidi Succinas (Potassium dehydroandrographolide succinate), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, is widely used for the treatment of viral pneumonia and viral upper respiratory tract infections because of its immunostimulatory, anti-infective and anti-inflammatory effect.
|
-
- HY-117506B
-
|
SBFI-26
|
FABP
|
Inflammation/Immunology
Neurological Disease
|
|
SBFI-26 is a selective and competitive inhibitor of fatty acid binding proteins FABP5 and FABP7, with Kis of 0.9 µM and 0.4 µM for FABP5 and FABP7, respectively. SBFI-26 produces anti-nociceptive and anti-inflammatory effects.
|
-
- HY-N1390
-
|
Syringaldehyde
|
COX
|
Metabolic Disease
Inflammation/Immunology
|
|
Syringaldehyde is a polyphenolic compound belonging to the group of flavonoids and is found in different plant species like Manihot esculenta and Magnolia officinalis. Syringaldehyde moderately inhibits COX-2 activity with an IC50 of 3.5 μg/mL. Anti-hyperglycemic and anti-inflammatory activities.
|
-
- HY-N0448
-
|
10-Gingerol
|
Others
|
Cancer
Inflammation/Immunology
|
|
10-Gingerol is a major pungent constituent in the ginger oleoresin from fresh rhizome, with anti-inflammatory, antioxidant and anti-proliferative activities. 10-Gingerol inhibits the proliferation of MDA-MB-231 tumor cell line with an IC50 of 12.1 μM.
|
-
- HY-14658
-
-
- HY-N6624
-
|
Skullcapflavone II
|
Bacterial
|
Inflammation/Immunology
|
|
Skullcapflavone II, a flavonoid derived from Scutellaria baicalensis, has anti-inflammatory, anti-microbial activities. Skullcapflavone II regulates osteoclast differentiation, survival, and function. Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG.
|
-
- HY-N0496
-
|
Ruscogenin
|
NOD-like Receptor (NLR)
|
Cardiovascular Disease
|
|
Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway and exerts significant anti-inflammatory and anti-thrombotic activities.
|
-
- HY-N7437
-
-
- HY-N6967
-
|
Levomenol
(-)-α-Bisabolol
|
Others
|
Inflammation/Immunology
Neurological Disease
|
|
Levomenol is a monocyclic sesquiterpene alcohol found in various plants and mainly in Matricaria chamomilla, which exerts antioxidant, anti-inflammatory, and anti-apoptotic activities. Levomenol has neuroprotective effects, can attenuate nociceptive behaviour and central sensitisation in a rodent model of trigeminal neuropathic pain.
|
-
- HY-N0579
-
|
Fraxin
Fraxoside
|
Phosphodiesterase (PDE)
|
Inflammation/Immunology
|
|
Fraxin isolated from Acer tegmentosum, F. ornus or A. hippocastanum, is a glucoside of fraxetin and reported to exert potent anti-oxidative stress action, anti-inflammatory and antimetastatic properties. Fraxin shows its antioxidative effect through inhibition of cyclo AMP phosphodiesterase enzyme.
|
-
- HY-110385
-
|
cGAMP disodium
Cyclic GMP-AMP disodium; 3',3'-cGAMP disodium
|
Endogenous Metabolite
|
Inflammation/Immunology
|
|
cGAMP disodium (Cyclic GMP-AMP disodium) is the third cyclic dinucleotide (CDN) to be discovered in bacteria. cGAMP disodium is an effective adjuvant for sublingual vaccination capable of promoting broad immunity including serum anti-PA neutralizing and anti-PA SIgA responses in airway secretions.
|
-
- HY-N1231
-
|
Sophoraflavanone G
Kushenol F
|
Apoptosis
|
Cancer
|
|
Sophoraflavanone G (Kushenol F) is iaolated from Sophora flavescens and shows anti-tumor and anti-inflammatory properties. Sophoraflavanone G (Kushenol F) induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways.
|
-
- HY-N1416
-
|
Pogostone
|
Bacterial
Apoptosis
Autophagy
|
Infection
Inflammation/Immunology
|
|
Pogostone is isolated from patchouli with anti-bacterial and anti-cancer activities. Pogostone inhibits both gram negative and gram positive bacteria, also show inhibitory effect on corynebacterium xerosis with a MIC value of 0.098 µg/ml . Pogostone induces cell apoptosis and autophagy.
|
-
- HY-N6924
-
|
Zingibroside R1
|
HIV
|
Infection
Metabolic Disease
|
|
Zingibroside R1 is dammaranae-type triterpenoid saponin, isolated from rhizomes, taproots, and lateral roots of Panax japonicas C. A. Meyer, shows excellent anti-tumor effects as well as anti-angiogenic activity.
Zingibroside R1 possesses some anti-HIV-1 activity.
Zingibroside R1 has inhibitory effects on the 2-deoxy-D-glucose (2-DG) uptake by EAT cells (IC50=91.3 μM).
|
-
- HY-N2447
-
|
Amarogentin
|
AMPK
Apoptosis
|
Cancer
Metabolic Disease
|
|
Amarogentin is a secoiridoid glycoside that is mainly extracted from Swertia and Gentiana roots. Amarogentin exhibits many biological effects, including anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin exerts hepatoprotective and immunomodulatory effects. Amarogentin promotes apoptosis, arrests G2/M cell cycle and downregulates of PI3K/Akt/mTOR signalling pathways. Amarogentin exerts beneficial vasculo-metabolic effect by activating AMPK.
|
-
- HY-N0875
-
-
- HY-N4259
-
-
- HY-B0494
-
-
- HY-100190
-
|
Amphethinile
Amphetinile; CRC 82-07
|
Microtubule/Tubulin
|
Cancer
|
|
Amphethinile is an anti-tubulin agent. The affinity constant for the association (Ka) of Amphethinile with tubulin is 1.3 μM.
|
-
- HY-B1079
-
-
- HY-B0576
-
-
- HY-N2596
-
-
- HY-N6722
-
-
- HY-13741
-
|
RH1
NSC 697726
|
Others
|
Cancer
|
|
RH1 (NSC 697726) is a potent bioreductive agent with profound anti-cancer activity in vitro and in vivo.
|
-
- HY-13075
-
-
- HY-100304
-
-
- HY-109056
-
|
Elsulfavirine
|
HIV
|
Infection
|
|
Elsulfavirine is a reverse transcriptase inhibitors for HIV-1 infection and is a new anti-HIV drug.
|
-
- HY-N0272
-
-
- HY-B0109A
-
-
- HY-W039897
-
-
- HY-B0485
-
-
- HY-N4290
-
-
- HY-114750
-
-
- HY-N6804
-
-
- HY-B0230
-
-
- HY-N3125
-
-
- HY-N4087
-
-
- HY-121632
-
|
Quinoclamine
|
NF-κB
|
Cancer
|
|
Quinoclamine, a naphthoquinone derivative, is a NF-κB inhibitor. Quinoclamine exhibits anti-cancer activity.
|
-
- HY-U00412
-
-
- HY-119369
-
-
- HY-N0588
-
-
- HY-N0578
-
-
- HY-12559
-
|
Alisporivir
Debio-025; DEB-025
|
HCV
|
Infection
|
|
Alisporivir (Debio-025) is a cyclophilin inhibitor molecule with potent anti-hepatitis C virus (HCV) activity.
|
-
- HY-B0367
-
-
- HY-17509
-
-
- HY-111529
-
|
Tafenoquine
WR 238605
|
Parasite
|
Infection
|
|
Tafenoquine (WR 238605) is an 8-aminoquinoline. Tafenoquine is an anti-malarial prophylactic agent.
|
-
- HY-76210
-
-
- HY-B0878
-
|
Halobetasol propionate
BMY-30056; CGP-14458; Ulobetasol propionate
|
Others
|
Others
|
|
Halobetasol propionate is a synthetic corticosteroid for topical dermatological use; exhibits anti-inflammatory, antipruritic, and vasoconstrictive properties.
|
-
- HY-B0808S
-
-
- HY-N2052
-
-
- HY-N5052
-
-
- HY-N2159
-
-
- HY-P1572
-
-
- HY-N6948
-
-
- HY-121241
-
|
Dehydroemetine
|
Parasite
|
Infection
|
|
Dehydroemetine, a synthetic analogue of emetine dihydrochloride, is used for visceral leishmaniasis. Dehydroemetine used for anti-parasites.
|
-
- HY-B0335
-
|
Tolfenamic Acid
GEA 6414
|
COX
|
Inflammation/Immunology
Cancer
|
|
Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.
|
-
- HY-N1778
-
-
- HY-N0201
-
|
Atractylenolide I
|
Toll-like Receptor (TLR)
JAK
STAT
|
Cancer
|
|
Atractylenolide I is a sesquiterpene derived from the rhizome of Atractylodes macrocephala, possesses diverse bioactivities, such as neuroprotective, anti-allergic, anti-inflammatory and anticancer properties. Atractylenolide I reduces protein levels of phosphorylated JAK2 and STAT3 in A375 cells, and acts as a TLR4-antagonizing agent.
|
-
- HY-A0143
-
-
- HY-16125
-
|
Carboxyamidotriazole Orotate
L-651582 Orotate; CAI Orotate
|
Calcium Channel
|
Cancer
Inflammation/Immunology
|
|
Carboxyamidotriazole Orotate (L-651582 Orotate) is the orotate salt form of Carboxyamidotriazole (CAI), an orally bioavailable signal transduction inhibitor. Carboxyamidotriazole Orotate is a cytostatic inhibitor of nonvoltage-operated calcium channels and calcium channel-mediated signaling pathways. Carboxyamidotriazole Orotate shows anti-tumor, anti-inflammatory and antiangiogenic effects.
|
-
- HY-N1517
-
|
Ganoderic acid C2
|
Others
|
Cancer
|
|
Ganoderic acid C2 is a bioactive triterpenoid in Ganoderma lucidum. Ganoderic acid C2 possesses the potential anti-tumor bioactivity, antihistamine, anti-aging and cytotoxic effects. Ganoderic acid C2 exhibits high inhibitory activity against the rat lens aldose reductase (RLAR) with an IC50 of 3.8 µM.
|
-
- HY-N0646
-
|
Silydianin
|
Phosphatase
|
Cancer
|
|
Silydianin is an active constituent of Silybium marianum, with exhibit anti-collagenase, antitumor and anti-elastase activities. Silydianin is a natural protein tyrosine phosphatase 1B (PTP1B) with an IC50 of 17.38 μM. Silydianin has inhibitory effect on the in vitro production and release of oxidative products.
|
-
- HY-106224
-
|
Orexin A (human, rat, mouse)
|
Orexin Receptor (OX Receptor)
|
Neurological Disease
|
|
Orexin A human, rat, mouse, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A human, rat, mouse is a specific, high-affinity agonist for G-protein-coupled receptor OX1R. Orexin A human, rat, mouse has a role in the regulation of feeding behavior. Orexin A human, rat, mouse is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.
|
-
- HY-123503
-
|
Salicortin
|
JNK
NF-κB
|
Inflammation/Immunology
Neurological Disease
|
|
Salicortin, a phenolic glycoside, has been isolated from many plants such as Populus and Salix species. Salicortin inhibits osteoclast differentiation and bone resorption by down-regulating JNK and NF-κB/NFATc1 signaling pathways. Salicortin has anti-amnesic, anti-adipogenic, and immune-modulatory activity.
|
-
- HY-P1306
-
|
Obestatin(rat)
|
GHSR
|
Inflammation/Immunology
Cardiovascular Disease
|
|
Obestatin(rat), encoded by the Ghrelin gene, is a cpeptide, comprised of 23 amino acids. Obestatin(rat) suppresses food intake, inhibits jejunal contraction, and decreases body-weight gain. Obestatin is an endogenous ligand of G-protein coupled receptor 39 (GPR39). Obestatin(rat) has anti-inflammatory, anti-myocardial infarction and antioxidant activities.
|
-
- HY-128587
-
|
SY-1365
|
CDK
|
Cancer
|
|
SY-1365 is a potent and first-in-class selective CDK7 inhibitor, with a Ki of 17.4 nM. SY-1365 exhibits anti-proliferative and apoptotic effects in solid tumor cell lines. SY-1365 possesses anti-tumor activity in hematological and multiple aggressive solid tumors.
|
-
- HY-N5020
-
|
Carabrone
|
Bacterial
|
Infection
|
|
Carabrone is isolated from the fruits of Carpesium abrotanoides , is a well-known sesquiterpene and exhibits significant anti-bacterial and anti-tumor activities.
Carabrone exhibits antifungal activities in vitro and in vivo against Botrytis cinerea, Colletotrichum lagenarium(EC50=7.10 μg/mL) and Erysiphe graminis.
|
-
- HY-N0759
-
-
- HY-114771
-
-
- HY-B0272
-
-
- HY-N3017
-
-
- HY-N6820
-
-
- HY-N2114
-
-
- HY-N6819
-
-
- HY-B1302
-
-
- HY-W015600
-
-
- HY-N1089
-
-
- HY-N1394
-
-
- HY-128939
-
|
EC0488
|
Antifolate
|
Cancer
|
|
EC0488 is used to synthesize EC0531 with folate receptor (FR)-specific and anti-tumor activities.
|
-
- HY-N0202
-
|
Atractylenolide II
Asterolide
|
Apoptosis
|
Cancer
|
|
Atractylenolide II is a sesquiterpene compound isolated from the dried rhizome of Atractylodes macrocephala (Baizhu in Chinese); anti-proliferative activity.
|
-
- HY-Y1362
-
-
- HY-125825
-
-
- HY-B0105
-
-
- HY-N0806
-
-
- HY-N6827
-
-
- HY-N0140
-
-
- HY-109082
-
-
- HY-N1399
-
-
- HY-N0418
-
-
- HY-N2441
-
-
- HY-B1832
-
-
- HY-N0228
-
-
- HY-N1037
-
-
- HY-B0392
-
-
- HY-N3519
-
|
Platycodin D3
|
HCV
|
Infection
|
|
Platycodin D3 is a triterpenoid saponin isolated from Platycodon grandiflorum, with anti-HCV activity.
|
-
- HY-101481
-
-
- HY-19191
-
-
- HY-101583
-
-
- HY-14938
-
-
- HY-112710
-
-
- HY-133025
-
-
- HY-12687
-
|
Tizoxanide
TIZ
|
Bacterial
HIV
Autophagy
|
Infection
|
|
Tizoxanide is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses.
|
-
- HY-130958
-
-
- HY-101482
-
-
- HY-17629
-
-
- HY-N5011
-
|
5,7-Dimethoxyflavone
|
Cytochrome P450
|
Cancer
Inflammation/Immunology
|
|
5,7-Dimethoxyflavone is one of the major components of Kaempferia parviflora, has anti-obesity, anti-inflammatory, and antineoplastic effects. 5,7-Dimethoxyflavone inhibits cytochrome P450 (CYP) 3As. 5,7-Dimethoxyflavone is also a potent Breast Cancer Resistance Protein (BCRP) inhibitor.
|
-
- HY-19828
-
|
Herboxidiene
GEX1A
|
DNA/RNA Synthesis
|
Cancer
|
|
Herboxidiene (GEX1A) is a potent phytotoxic polyketide from Streptomyces sp. A7847 with a diverse range of activities, including herbicidal, anti-cholesterol, anti-tumor effects. Herboxidiene inhibits the pre-mRNA splicing process by binding to spliceosome-associated protein (SAP) 155, a subunit of SF3b, in the splicesome.
|
-
- HY-W009156
-
-
- HY-118284
-
|
Vicagrel
|
P2Y Receptor
|
Cardiovascular Disease
|
|
Vicagrel, an acetate derivative of Clopidogrel, is a P2Y12 platelet inhibitor potentially for the treatment of thrombosis, the substrate of carboxylesterase 2 (CES2). Vicagrel demonstrates a favorable safety profile and excellent anti-platelet activity, which could be an anti-platelet drug and for the unmet medical needs of cardiovascular diseases.
|
-
- HY-126397
-
|
MnTBAP chloride
|
NF-κB
|
Inflammation/Immunology
|
|
MnTBAP chloride is a superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. MnTBAP chloride is a manganic porphyrin complex and has anti-oxidative property. MnTBAP chloride mediates anti-inflammatory effects through upregulation of BMPR-II and inhibition of the NFκB signaling. MnTBAP chloride has the potential for the fibrotic response in chronic kidney diseases (CKDs) research.
|
-
- HY-129555
-
|
Surfactin
|
Bacterial
HSV
Antibiotic
|
Infection
|
|
Surfactin is a potent cyclic lipopeptide biosurfactants that mediates flux of mono-and divalent cations, such as calcium, across lipid bilayer membranes. Surfactin can act as an antimicrobial adjuvant with anti-bacterial, anti-fungal, antimycoplasma and hemolytic effects. Surfactin also has antiviral activity against a variety of enveloped viruses.
|
-
- HY-W012126
-
|
2,6-Dichlorodiphenylamine
2,6-Dichloro-N-phenylaniline
|
Bacterial
|
Cancer
Infection
|
|
2,6-Dichlorodiphenylamine is an analogue of Diclofenac Sodium (HY-15037) and has anti-Candida albicans activity. Diclofenac Sodium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells.
|
-
- HY-130208
-
|
Thiodigalactoside
TDG
|
Galectin
|
Cancer
Metabolic Disease
Inflammation/Immunology
|
|
Thiodigalactoside (TDG) is an orally active and potent galectin (GAL) inhibitor with Kd values of 24 μM, 49 μM for GAL1 and GAL3, respectively. Thiodigalactoside, a non-metabolizable disaccharide, has anti-inflammatory and anti-cancer activity. Thiodigalactoside dramatically reduces body weight gain in diet-induced obese rats.
|
-
- HY-105028
-
|
Tenidap
CP-66248
|
COX
|
Inflammation/Immunology
|
|
Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 µM and 1.2 µM for COX-1 and COX-2, respectively. Tenidap has anti-inflammatory and antirheumatic properties. Tenidap is also a specific SLC26A3 inhibitor.
|
-
- HY-121636
-
|
Resolvin D2
RvD2
|
TRP Channel
|
Infection
Inflammation/Immunology
Neurological Disease
|
|
Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC50 = 0.1 nM) and TRPA1 (IC50 = 2 nM) in primary sensory neurons.
|
-
- HY-B0195
-
-
- HY-15505
-
|
RWJ-67657
JNJ 3026582
|
p38 MAPK
|
Cancer
Inflammation/Immunology
Cardiovascular Disease
|
|
RWJ-67657 (JNJ 3026582) is an orally active and selective p38α and p38β MAPK inhibitor with IC50s of 1 and 11 μM, respectively. RWJ-67657 displays no activity at p38γ and p38δ, and exhibits cardio protective effect. Anti-inflammatory and anti-tumor activity.
|
-
- HY-N0794
-
|
Proanthocyanidins
|
Bacterial
Fungal
|
Cancer
Infection
Inflammation/Immunology
Cardiovascular Disease
|
|
Proanthocyanidins are a class of polyphenolic that are widely distributed in higher plants, consisted of an electrophilic flavanyl unit. Proanthocyanidins can be used as antioxidant and anti-cancers agent. Proanthocyanidins also exhibit anti-inflammatory, cardioprotective, antibacterial and antifungal properties, which can be used in the treatment of chronic venous insufficiency, capillary fragility, sunburn and retinopathy..
|
-
- HY-P1306A
-
|
Obestatin(rat) TFA
|
GHSR
|
Inflammation/Immunology
Cardiovascular Disease
|
|
Obestatin(rat) TFA, encoded by the Ghrelin gene, is a cpeptide, comprised of 23 amino acids. Obestatin(rat) TFA suppresses food intake, inhibits jejunal contraction, and decreases body-weight gain. Obestatin is an endogenous ligand of G-protein coupled receptor 39 (GPR39). Obestatin(rat) TFA has anti-inflammatory, anti-myocardial infarction and antioxidant activities.
|
-
- HY-111551
-
|
FT113
|
Fatty Acid Synthase (FASN)
|
Cancer
|
|
FT113 is a potent and orally active fatty acid synthase (FASN) inhibitor, with an IC50 of 213 nM for full-length recombinant human FASN enzyme. In cell-based assay, FT113 blocks FASN activity in BT474 cells (IC50, 90 nM). FT113 shows anti-proliferative activity, and exhibits anti-cancer activity both in vitro and in vivo.
|
-
- HY-N0313
-
|
Euphol
|
Endogenous Metabolite
MAGL
|
Inflammation/Immunology
|
|
Euphol is a tetracyclic triterpene alcohol isolated from the sap of Euphorbia tirucalli with anti-mutagenic, anti-inflammatory and immunomodulatory effects, orally active. Euphol inhibits the monoacylglycerol lipase (MGL) activity via a reversible mechanism (IC50=315 nM). MGL inhibition in the periphery modulates the endocannabinoid system to block the development of inflammatory pain.
|
-
- HY-B0195A
-
-
- HY-N6928
-
-
- HY-101566A
-
-
- HY-N1981
-
-
- HY-N0516
-
|
Casticin
Vitexicarpin
|
STAT
|
Inflammation/Immunology
|
|
Casticin is a methyoxylated flavonol isolated from Viticis Fructus, with antimitotic and anti-inflammatory effect. Casticin inhibits the activation of STAT3.
|
-
- HY-B0388
-
|
Probucol
DH-581
|
Virus Protease
|
Metabolic Disease
|
|
Probucol (DH-581) is an anti-hyperlipidemic drug by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.
|
-
- HY-N2263
-
|
Skimmin
Umbelliferone glucoside
|
Others
|
Inflammation/Immunology
|
|
Skimmin (Umbelliferone glucoside) is a coumarin found in Hydrangea paniculata, inhibits immune complex deposition, with anti-inflammatory activity.
|
-
- HY-N0719
-
-
- HY-13702
-
|
Nilutamide
Nilandron; RU 23908
|
Androgen Receptor
|
Cancer
|
|
Nilutamide (Nilandron) is a non-steroidal anti-androgen drug proposed in the treatment of metastatic prostatic carcinoma.
|
-
- HY-N6975
-
|
Glyasperin D
|
Bacterial
|
Infection
|
|
Glyasperin D is a flavonoid isolated from Glycyrrhiza uralensis, and possesses weaker anti-Helicobacter pylori activity.
|
-
- HY-N0889
-
-
- HY-B1896B
-
-
- HY-128576
-
|
DS21360717
|
Others
|
Cancer
|
|
DS21360717 is a potent and orally active FER tyrosine kinase inhibitor, with an IC50 of 0.49 nM. Anti-cancer activity.
|
-
- HY-B1153A
-
-
- HY-10574
-
-
- HY-100495
-
-
- HY-N3460
-
-
- HY-101506
-
-
- HY-N0576
-
-
- HY-P1581
-
|
Ceratotoxin A
|
Bacterial
|
Infection
|
|
Ceratotoxin A, a 29-residue peptide isolated from the accessory gland secretion fluid, with strong anti-bacterial activity.
|
-
- HY-111529A
-
-
- HY-135658
-
-
- HY-N2401
-
-
- HY-N1411
-
-
- HY-Y0078
-
-
- HY-17390
-
-
- HY-N0428
-
|
Obacunone
|
Apoptosis
|
Cancer
|
|
Obacunone, isolated from seeds of Marsh White grapefruit, exhibits anti-tumor activity by the induction of apoptosis.
|
-
- HY-N0878
-
-
- HY-N0421
-
|
Cinobufagin
Cinobufagine
|
Autophagy
Apoptosis
|
Cancer
|
|
Cinobufagin, a kind of Chinese materia medica with antitumor effect, is widely used in clinical practice, especially in anti-liver cancer.
|
-
- HY-101566
-
|
BAY-1895344
|
ATM/ATR
|
Cancer
|
|
BAY-1895344 is a potent, orally available and selective ATR inhibitor, with IC50 of 7 nM. Anti-tumor activity.
|
-
- HY-P1034
-
|
DAPTA
D-Ala-peptide T-amide; Adaptavir
|
CCR
HIV
|
Infection
Endocrinology
|
|
DAPTA is a synthetic peptide, functions as a viral entry inhibitor by targeting selectively CCR5, and shows potent anti-HIV activities.
|
-
- HY-W018791
-
|
Bifendate
DDB
|
HBV
|
Infection
|
|
Bifendate (DDB) is a synthetic intermediate of Schisandrin C with anti-HBV efficacy in research of chronic hepatitis B.
|
-
- HY-19727A
-
-
- HY-131118
-
-
- HY-N3544
-
-
- HY-N0562
-
-
- HY-12384
-
|
Tenosal
|
Others
|
Inflammation/Immunology
|
|
Tenosal is a new compound obtained by esterifying salicylic acid with 2-thiophene-carboxylic acid and displays anti-inflammatory, analgesic and antipyretic properties.
|
-
- HY-N6015
-
|
Bacopasaponin C
|
Others
|
Cancer
|
|
Bacopasaponin C is an indigenous glycoside isolated from Bacopa monniera, with antitumor and anti-leishmanial activities.
|
-
- HY-B1114
-
|
Gliquidone
AR-DF 26
|
Others
|
Metabolic Disease
|
|
Gliquidone (AR-DF 26) is an anti-diabetic drug in the sulfonylurea class, used in the treatment of diabetes mellitus type 2.
|
-
- HY-121235
-
-
- HY-U00022
-
-
- HY-19025
-
-
- HY-N1405
-
|
Cucurbitacin I
Elatericin B; JSI-124; NSC-521777
|
STAT
JAK
|
Cancer
|
|
Cucurbitacin I is a natural selective inhibitor of JAK2/STAT3, with potent anti-cancer activity.
|
-
- HY-102007
-
|
Gamitrinib TPP
|
HSP
|
Cancer
|
|
Gamitrinib TPP is a Gamitrinib (GA) mitochondrial matrix inhibitor. Gamitrinib TPP is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity.
|
-
- HY-N0246
-
-
- HY-N2842
-
-
- HY-17390A
-
-
- HY-N2356
-
-
- HY-W050154
-
|
Kojic acid
|
Parasite
|
Infection
|
|
Kojic acid is a natural substance produced by Aspergillus oryzae, also used as an anti-oxidant and radio-protective agent.
|
-
- HY-U00181
-
|
Fludazonium chloride
R23633
|
Fungal
|
Infection
|
|
Fludazonium chloride (R23633) is an anti-fungal agent, which can be used in the treatment and prevention of superficial and systemic fungal infections.
|
-
- HY-104025
-
-
- HY-107831
-
-
- HY-N0674A
-
|
Dehydrocorydaline chloride
13-Methylpalmatine chloride
|
Bcl-2 Family
Caspase
PARP
p38 MAPK
Parasite
Autophagy
|
Cancer
Infection
|
|
Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid isolated from traditional Chinese herb Corydalis yanhusuo W.T. Wang. Dehydrocorydaline regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline chloride elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities.. Dehydrocorydaline chloride shows strong anti-malarial effects (IC50 =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain.
|
-
- HY-N0674
-
|
Dehydrocorydaline
13-Methylpalmatine
|
Bcl-2 Family
Caspase
PARP
p38 MAPK
Parasite
Autophagy
|
Cancer
Infection
|
|
Dehydrocorydaline (13-Methylpalmatine) is an alkaloid isolated from traditional Chinese herb Corydalis yanhusuo W.T. Wang. Dehydrocorydaline regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities.. Dehydrocorydaline shows strong anti-malarial effects (IC50 =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain.
|
-
- HY-Y0189
-
|
Methyl Salicylate
Wintergreen oil
|
COX
|
Inflammation/Immunology
|
|
Methyl Salicylate (Wintergreen oil) is a topical analgesic and anti-inflammatory agent. Also used as a pesticide, a denaturant, a fragrance ingredient, and a flavoring agent in food and tobacco products. A systemic acquired resistance (SAR) signal in tobacco. A topical nonsteroidal anti-inflammatory drug (NSAID). Methyl salicylate lactoside is a COX inhibitor.
|
-
- HY-13755
-
|
Sulforaphane
|
HDAC
Keap1-Nrf2
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
Sulforaphane is an isothiocyanate present naturally in widely consumed vegetables. Sulforaphane increases tumor suppressor protein transcription and inhibits histone deacetylase activity. Sulforaphane activates Nrf2 and inhibits high glucose-induced progression of pancreatic cancer via AMPK dependent signaling. Sulforaphane has shown anti-cancer and anti-inflammatory activities.
|
-
- HY-N1067
-
|
Xanthohumol
|
COX
Acyltransferase
Apoptosis
HSV
CMV
Influenza Virus
|
Cancer
Infection
|
|
Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2 and cytomegalovirus (CMV).
|
-
- HY-16531A
-
|
YF-2 hydrochloride
|
Histone Acetyltransferase
|
Cancer
Neurological Disease
|
|
YF-2 hydrochloride is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease.
|
-
- HY-P1102
-
|
TC14012
|
CXCR
HIV
|
Cancer
Infection
|
|
TC14012, a serum-stable derivative of T140, is a selective and peptidomimetic inverse CXCR4 agonist with an IC50 of 19.3 nM. TC14012 is a potent CXCR7 agonist an EC50 of 350 nM for recruiting β-arrestin 2 to CXCR7. TC14012 has anti-HIV activity and anti-cancer activity.
|
-
- HY-B1452
-
|
Licofelone
ML-3000
|
COX
Lipoxygenase
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor (IC50=0.21/0.18 μM, respectively) for the treatment of osteoarthritis. Licofelone exerts anti-inflammatory and anti-proliferative effects. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins.
|
-
- HY-N0292
-
|
Oleuropein
|
PPAR
Apoptosis
Aromatase
|
Cancer
Inflammation/Immunology
Cardiovascular Disease
|
|
Oleuropein, found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects through direct inhibition of PPARγ transcriptional activity. Oleuropein induces apoptosis in breast cancer cells via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Oleuropein also inhibits aromatase.
|
-
- HY-N0587
-
|
Demethylzeylasteral
|
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
Demethylzeylasteral is a triterpene compound isolated from Tripterygium wilfordii Hook F, with anti-inflammatory, immunosuppressive and anti-tumor activities. Demethylzeylasteral can significantly alleviates atherosclerosis (AS). Demethylzeylasteral inhibits triple-negative breast cancer invasion by blocking the canonical and non-canonical TGF-β signaling pathways.
|
-
- HY-106224A
-
|
Orexin A (human, rat, mouse) (TFA)
|
Orexin Receptor (OX Receptor)
|
Neurological Disease
|
|
Orexin A human, rat, mouse TFA, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A human, rat, mouse TFA is a specific, high-affinity agonist for G-protein-coupled receptor OX1R. Orexin A human, rat, mouse TFA has a role in the regulation of feeding behavior. Orexin A human, rat, mouse TFA is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.
|
-
- HY-114454
-
|
INH14
|
IKK
|
Cancer
Inflammation/Immunology
|
|
INH14 is a cell permeable inhibitor of IKKα/IKKβ, with IC50s of 8.97 and 3.59 μM, respectively. INH14 inhibits the IKKα/β-dependent TLR inflammatory response. INH14 also inhibits downstream of TAK1/TAB1 and NF-kB pathways. Anti-inflammatory and anti-cancer activity.
|
-
- HY-16531
-
|
YF-2
|
Histone Acetyltransferase
|
Cancer
Neurological Disease
|
|
YF-2 is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease.
|
-
- HY-14374
-
|
GPP78
CAY10618
|
Nampt
Autophagy
|
Cancer
Inflammation/Immunology
|
|
GPP78 (CAY10618) is a potent Nampt inhibitor with an IC50 of 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion. GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y cells with an IC50 of 3.8 nM by inducing autophagy. GPP78 has anti-cancer and anti-inflammatory effects.
|
-
- HY-12383
-
|
Pelubiprofen
|
COX
|
Inflammation/Immunology
Neurological Disease
|
|
Pelubiprofen, an orally active and non-steroidal anti-inflammatory drug, is a member of the 2-arylpropionic acid family and has relatively selective effects on COX-2 activity. Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway, and has significant anti-inflammatory and analgesic effects.
|
-
- HY-130605
-
|
BAY-1797
|
P2X Receptor
|
Neurological Disease
|
|
BAY-1797 is a potent, orally active, and selective P2X4 antagonist, with an IC50 of 211 nM against human P2X4. BAY-1797 displays no or very weak activity on the other P2X ion channels. BAY-1797 shows anti-nociceptive and anti-inflammatory effects.
|
-
- HY-N2587
-
|
Irigenin
|
Integrin
|
Cancer
|
|
Irigenin is a is a lead compound, and mediates its anti-metastatic effect by specifically and selectively blocking α9β1 and α4β1 integrins binding sites on C-C loop of Extra Domain A (EDA). Irigenin shows anti-cancer properties. It sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells.
|
-
- HY-N6263
-
|
EGCG Octaacetate
|
Bacterial
|
Infection
Cardiovascular Disease
|
|
EGCG Octaacetate is a prodrug of Green tea epigallocatechin-3-gallate (EGCG), utilized to enhance the stability and bioavailability of EGCG in vivo. EGCG Octaacetate has high efficacy, bioavailability, anti-oxidation and anti-angiogenesis capacities. EGCG octaacetate is the potential antibacterial compound for gram-positive bacteria (GPB) and gram-negative bacteria (GNB) .
|
-
- HY-15121
-
|
L-Theanine
L-Glutamic Acid γ-ethyl amide; Nγ-Ethyl-L-glutamine
|
Apoptosis
|
Neurological Disease
|
|
L-Theanine (L-Glutamic Acid γ-ethyl amide）is a non-protein amino acid contained in green tea leaves, which blocks the binding of L-glutamic acid to glutamate receptors in the brain, and with neuroprotective and anti-oxidative activities. L-Theanine causes anti-stress effects via the inhibition of cortical neuron excitation by oral intake.
|
-
- HY-17592
-
|
Bithionol
|
Parasite
|
Cancer
|
|
Bithionol is a clinically approved anti-parasitic drug; has been shown to inhibit solid tumor growth in several preclinical cancer models.
|
-
- HY-128580
-
|
FAK inhibitor 2
|
FAK
|
Cancer
|
|
FAK inhibitor 2 is a potent focal adhesion kinase (FAK) inhibitor with an IC50 of 0.07 nM, with antitumor and anti-angiogenesis activities.
|
-
- HY-12651
-
|
Primaquine Diphosphate
Primaquine phosphate; Primaquine bisphosphate
|
Parasite
|
Infection
|
|
Primaquine is the only generally available anti-malarial that prevents relapse in vivax and ovale malaria, and the only potent gametocytocide in falciparum malaria.
|
-
- HY-N1103A
-
-
- HY-N7036
-
-
- HY-N0862
-
-
- HY-100039
-
|
YYA-021
|
HIV
|
Infection
|
|
YYA-021 is a small-molecule CD4 mimic that inhibits HIV entry, with high anti-HIV activity and low cytotoxicity.
|
-
- HY-N2415
-
|
Podophyllotoxone
|
Microtubule/Tubulin
|
Cancer
|
|
Podophyllotoxone is isolated from the roots of Dysosma versipellis and has anti-cancer activities.Podophyllotoxone is able to inhibit the tubulin polymerization.
|
-
- HY-N0318
-
-
- HY-N1178
-
-
- HY-U00187
-
|
NCX1022
|
Others
|
Inflammation/Immunology
|
|
NCX1022 is an NO-releasing derivative of Hydrocortisone, which is the most widely used anti-inflammatory drug for the treatment of skin inflammation.
|
-
- HY-N0372
-
|
Licochalcone A
Licochalcone-A
|
Autophagy
|
Cancer
|
|
Licochalcone A, a flavonoid isolated from the famous Chinese medicinal herb Glycyrrhiza uralensis Fisch, presents obvious anti-cancer effects.
|
-
- HY-103096
-
|
R162
|
Others
|
Cancer
|
|
R162 is a potent inhibitor of glutamate dehydrogenase 1 (GDH1/GLUD1), with anti-cancer properties.
|
-
- HY-N0131
-
-
- HY-B0686
-
-
- HY-135848
-
-
- HY-N2488
-
-
- HY-B0493
-
-
- HY-N4326
-
-
- HY-N2224
-
|
Guaijaverin
|
Bacterial
|
Infection
|
|
Guaijaverin is a urease inhibitor with an IC50 of 120 μM. Guaijaverin shows antioxidant and anti-Streptococcus mutans activities.
|
-
- HY-N4252
-
|
Periplocymarin
|
Others
|
Cancer
|
|
Periplocymarin, a cardiac glycoside isolated from Periploca sepium and Periploca graeca, is a potential anti-cancer compound.
|
-
- HY-N5022
-
|
Evolitrine
7-Methoxydictamnine; Evolitrin
|
Others
|
Inflammation/Immunology
|
|
Evolitrine (7-Methoxydictamnine; Evolitrin) is isolated from Acronychia pedunculata and show anti-inflammatory and antifeedant activities.
|
-
- HY-N6904
-
-
- HY-N0743
-
|
Senkyunolide A
|
Others
|
Cancer
|
|
Senkyunolide A, isolated from Ligusticum chuanxiong Hort, has cytoprotective and antiproliferative activities. Anti-tumor activity.
|
-
- HY-76251
-
-
- HY-N6926
-
-
- HY-N0661
-
-
- HY-B0686A
-
-
- HY-A0273
-
|
Propyphenazone
4-IsopropylAntipyrine; Isopropylphenazone
|
COX
|
Inflammation/Immunology
|
|
Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.
|
-
- HY-107208
-
-
- HY-N0016
-
|
Glycitein
Glycetein
|
Apoptosis
|
Cancer
|
|
Glycitein is a soybean (yellow cultivar) isoflavonoid; used in combination with other isoflavonoids such as genistein and daidzein to study apoptosis and anti-oxidation processes.
|
-
- HY-B0432AS
-
-
- HY-N2597
-
-
- HY-16674
-
-
- HY-105808
-
-
- HY-N1103
-
|
Vasicine
Peganine
|
Others
|
Inflammation/Immunology
|
|
Vasicine (peganine) is a quinazoline alkaloid isolated from Justicia adhatoda. Vasicine (peganine) possesses anti- tuberculosis activity.
|
-
- HY-N0637
-
-
- HY-78131B
-
-
- HY-N0714
-
|
Berbamine
|
NF-κB
Autophagy
|
Cancer
|
|
Berbamine is a natural compound extracted from traditional Chinese medicine Barberry with anti-tumor, immunomodulatory and cardiovascular effects. Berbamine is a calcium channel blocker.
|
-
- HY-N2242
-
|
Hosenkoside G
|
Others
|
Cancer
|
|
Hosenkoside G, a baccharane glycoside isolated from the seeds of Impatiens Balsamina L., possesses anti-tumor activity.
|
-
- HY-14658S
-
-
- HY-P1102A
-
|
TC14012 TFA
|
CXCR
HIV
|
Cancer
Infection
|
|
TC14012 TFA, a serum-stable derivative of T140, is a selective and peptidomimetic inverse CXCR4 agonist with an IC50 of 19.3 nM. TC14012 TFA is a potent CXCR7 agonist an EC50 of 350 nM for recruiting β-arrestin 2 to CXCR7. TC14012 TFA has anti-HIV activity and anti-cancer activity.
|
-
- HY-107818
-
|
4-Hydroxychalcone
|
NF-κB
|
Inflammation/Immunology
Cardiovascular Disease
|
|
4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity. 4-Hydroxychalcone inhibits TNF-α induced NF-κB pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice.
|
-
- HY-N0831
-
|
Jaceosidin
|
Bcl-2 Family
COX
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
Jaceosidin is a flavonoid isolated from Artemisia vestita, induces apoptosis in cancer cells, activates Bax and down-regulates Mcl-1 and c-FLIP expression. Jaceosidin exhibits anti-cancer, anti-inflammatory activities, decreases leves of inflammatory markers, and suppresses COX-2 expression and NF-κB activation.
|
-
- HY-P2320
-
|
IDR-1
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
IDR-1 is an antimicrobial peptide that is active against Gram-positive and Gram-negative bacteria. IDR-1 counters infection by selective modulation of innate immunity without obvious toxicities. IDR-1 has anti-inflammatory and anti-infective properties, enhances the levels of monocyte chemokines, and attenuates pro-inflammatory cytokine release.
|
-
- HY-N4238
-
|
Dehydrocorydaline nitrate
13-Methylpalmatine nitrate
|
Bcl-2 Family
Caspase
PARP
p38 MAPK
Parasite
Autophagy
|
Cancer
Infection
|
|
Dehydrocorydaline nitrate (13-Methylpalmatine nitrate) is an alkaloid isolated from traditional Chinese herb Corydalis yanhusuo W.T. Wang. Dehydrocorydaline regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline nitrate elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities.. Dehydrocorydaline nitrate shows strong anti-malarial effects (IC50 =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain.
|
-
- HY-N0625A
-
-
- HY-18978
-
-
- HY-17431
-
|
Fosamprenavir Calcium Salt
GW433908G
|
HIV
|
Infection
|
|
Fosamprenavir Calcium Salt (GW433908G) is a phosphate ester prodrug of the antiretroviral protease inhibitor Amprenavir, with improved solubility. Anti-HIV infection.
|
-
- HY-B1001A
-
-
- HY-12485
-
|
TBA-354
|
Bacterial
Antibiotic
|
Infection
|
|
TBA-354 is a potent anti-tuberculosis compound; maintains activity against Mycobacterium tuberculosis H37Rv isogenic monoresistant strains.
|
-
- HY-19727
-
-
- HY-B0394
-
-
- HY-P1728
-
|
Super-TDU 1-31
|
YAP
|
Cancer
|
|
Super-TDU (1-31) is a peptide of Super-TDU, which is an inhibitor of YAP-TEADs, shows potent anti-tumor activity.
|
-
- HY-12785
-
|
Albendazole sulfoxide
Ricobendazole; Albendazole oxide
|
Parasite
|
Infection
|
|
Albendazole sulfoxide (Ricobendazole), the main active metabolite of Albendazole, exhibits anti-parasite effect against Echinococcus multilocularis Metacestodes.
|
-
- HY-135317
-
-
- HY-32735
-
|
Triptolide
PG490
|
NF-κB
Apoptosis
|
Cancer
|
|
Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory and antiproliferative effects. Triptolide is a NF-κB activation inhibitor.
|
-
- HY-N0891
-
|
Tubeimoside II
Tubeimoside-B
|
Others
|
Cancer
|
|
Tubeimoside II(Tubeimoside-B) is a natural analogue of oleanane type of triterpenoid saponin; show anti-inflammatory, antitumor, and antitumor-promoting effects.
|
-
- HY-N0028
-
-
- HY-B0421S
-
|
Mycophenolic acid D3
Mycophenolate D3
|
Others
|
Others
|
|
Mycophenolic acid D3 (Mycophenolate D3) is deuterium labeled Mycophenolic acid, which is an an immunosuppresant drug and has potent anti-proliferative activity.
|
-
- HY-W012732
-
|
Isoquinoline
|
Others
|
Cancer
|
|
Isoquinoline is an analog of pyridine. Isoquinoline structural-based alkaloids, such as tropoloisoquinoline, phthalideisoquinoline, and naphthylisoquinoline has anti-cancer activities.
|
-
- HY-107789
-
-
- HY-B1153
-
|
Glafenine
Glafenin
|
Others
|
Inflammation/Immunology
|
|
Glafenine is a non-steroidal anti-inflammatory drug (NSAID), is a non-narcotic analgesic agent, widely used for the treatment of pains of various origins.
|
-
- HY-16265
-
-
- HY-P1728A
-
-
- HY-102007A
-
|
Gamitrinib TPP hexafluorophosphate
|
HSP
|
Cancer
|
|
Gamitrinib TPP hexafluorophosphate is a Gamitrinib (GA) mitochondrial matrix inhibitor. Gamitrinib TPP hexafluorophosphate is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity.
|
-
- HY-111149
-
-
- HY-78726
-
|
Fosamprenavir
Amprenavir phosphate; GW 433908
|
HIV
|
Infection
|
|
Fosamprenavir (Amprenavir phosphate;GW 433908) is a phosphate ester prodrug of the antiretroviral protease inhibitor Amprenavir, with improved solubility. Anti-HIV infection.
|
-
- HY-N6075
-
|
Specneuzhenide
Nuezhenide
|
Others
|
Cancer
|
|
Specneuzhenide (Nuezhenide) is a phenol glycoside isolated from Ligustrum sinense. Specneuzhenide (Nuezhenide) possesses anti-tumor activity.
|
-
- HY-W031757
-
-
- HY-19217
-
-
- HY-N6894
-
-
- HY-B0580A
-
-
- HY-N1408
-
-
- HY-B1001
-
-
- HY-N2082
-
|
Isorhamnetin 3-O-galactoside
Cacticin
|
Others
|
Inflammation/Immunology
Cardiovascular Disease
|
|
Isorhamnetin 3-O-galactoside (Cacticin), a flavonoid glycoside isolated from Artemisia capillaris Thunberg, which ameliorates CCl4-induced hepatic damage by enhancing the anti-oxidative defense system and reducing the inflammatory signaling pathways. Isorhamnetin 3-O-galactoside (Cacticin) has antithrombotic and anti-inflammatory activities.
|
-
- HY-12554
-
|
Terlipressin
|
Vasopressin Receptor
|
Endocrinology
Inflammation/Immunology
Cardiovascular Disease
|
|
Terlipressin is a vasopressin analogue with potent vasoactive properties. Terlipressin is a highly selective vasopressin V1 receptor agonist that reduces the splanchnic blood flow and portal pressure and controls acute variceal bleeding. Terlipressin exerts anti-inflammatory and anti-oxidative effects. Terlipressin has the potential for hepatorenal syndrome and norepinephrine-resistant septic shock research.
|
-
- HY-111024
-
|
2,2,5,7,8-Pentamethyl-6-Chromanol
PMC
|
Androgen Receptor
|
Cancer
|
|
2,2,5,7,8-Pentamethyl-6-Chromanol (PMC) is the anti-oxidant moiety of vitamin E (α-tocopherol). 2,2,5,7,8-Pentamethyl-6-Chromanol has potent androgen receptor (AR) signaling modulation and anti-cancer activity against prostate cancer cell lines.
|
-
- HY-12554A
-
|
Terlipressin acetate
|
Vasopressin Receptor
|
Endocrinology
Inflammation/Immunology
Cardiovascular Disease
|
|
Terlipressin acetate is a vasopressin analogue with potent vasoactive properties. Terlipressin acetate is a highly selective vasopressin V1 receptor agonist that reduces the splanchnic blood flow and portal pressure and controls acute variceal bleeding. Terlipressin acetate exerts anti-inflammatory and anti-oxidative effects. Terlipressin acetate has the potential for hepatorenal syndrome and norepinephrine-resistant septic shock research.
|
-
- HY-135674
-
|
SR-318
|
p38 MAPK
TNF Receptor
|
Cancer
Inflammation/Immunology
|
|
SR-318 is a potent and highly selective p38 MAPK inhibitor with IC50s of 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively. SR-318 potently inhibits the TNF-α release in whole blood with an IC50 of 283 nM. SR-318 has anti-cancer and anti-inflammatory activity.
|
-
- HY-107794
-
|
Clodronate disodium tetrahydrate
Disodium clodronate tetrahydrate
|
Others
|
Inflammation/Immunology
Neurological Disease
|
|
Clodronate disodium tetrahydrate (Disodium clodronate tetrahydrate) is first-generation bisphosphonate, with anti-osteoporotic, anti-inflammatory and analgesic effects. Clodronate disodium tetrahydrate is a selective, potent, reversible and Cl - competitive vesicular nucleotide transporter (VNUT) inhibitor, with an IC50 of 15.6 nM. Clodronate disodium tetrahydrate inhibits vesicular ATP release from neurons and reduces chronic neuropathic and inflammatory pain.
|
-
- HY-B0559
-
|
Nabumetone
BRL14777
|
COX
|
Inflammation/Immunology
Cancer
|
|
Nabumetone is an orally active non-acidic anti-inflammatory agent, acts as a potent and selective COX-2 inhibitor, and is the prodrug of the active metabolite 6MNA.
|
-
- HY-78131
-
-
- HY-18714
-
|
BRD7116
|
Others
|
Others
|
|
BRD7116 competitively binds to bacterial DNA gyrase, exhibits an EC50 of 200 nM for LSCe cells, with cell-non-autonomous anti-leukemia activity.
|
-
- HY-B0432A
-
-
- HY-111758
-
-
- HY-B1026
-
-
- HY-N0685
-
|
Pseudohypericin
|
HIV
|
Infection
|
|
Pseudohypericin and its congener Hypericin are the major hydroxylated phenanthroperylenediones present in Hypericum species. Pseudohypericin shows anti-HIV activity.
|
-
- HY-N1983
-
|
Caudatin
|
Apoptosis
|
Cancer
|
|
Caudatin is a steroidal cmpound found in Cynanchum auriculatum, causes cell cycle arrest and induces apoptosis, with anti-cancer and antiangiogenic properties.
|
-
- HY-101570
-
|
Nedisertib
M3814
|
DNA-PK
|
Cancer
|
|
Nedisertib (M3814) is a potent, orally available and selective inhibitor of DNA-PK, with an IC50 of <3 nM. Anti-tumor activity.
|
-
- HY-112712
-
|
Cyclophilin inhibitor 1
|
HCV
|
Infection
|
|
Cyclophilin inhibitor 1 is a potent and orally bioavailable cyclophilin A inhibitor, with a Kd of 5 nM, shows effective anti-HCV activity, with an EC50 of 98 nM for HCV 2a.
|
-
- HY-N3733
-
|
Deoxylapachol
|
Fungal
|
Cancer
Infection
|
|
Deoxylapachol is a major cytotoxic component of New Zealand brown alga, Landsburgia quercifolia. Deoxylapachol has antifungal and anti-cancer activity.
|
-
- HY-N0015
-
|
Astragalin
Astragaline; 3-Glucosylkaempferol; Kaempferol 3-β-D-glucopyranoside
|
Apoptosis
|
Inflammation/Immunology
Cancer
|
|
Astragalin (kaempferol-3-O-glucoside) is a flavonoid with anti-inflammatory activity and newly found in persimmon leaves and green tea seeds.
|
-
- HY-W011704A
-
-
- HY-N7089
-
|
Benzoyleneurea
|
Bacterial
|
Infection
|
|
Benzoyleneurea possesses anti-bacterial activity. Benzoyleneurea scaffold can be used in the synthesis of novel protein geranylgeranyltransferase-I (PGGTase-I) inhibitors.
|
-
- HY-N4189
-
|
Isocucurbitacin B
|
Others
|
Cancer
|
|
Isocucurbitacin B is a potent cytotoxic compound isolated from Helicteres rswa L. (Sterculiaceae). Isocucurbitacin B possesses anti-tumor acticity.
|
-
- HY-P0173B
-
|
Chlorotoxin TFA
|
Chloride Channel
|
Cancer
|
|
Chlorotoxin TFA is a peptide isolated from the venom of the scorpion Leiurus quinquestriatus, acts as a chloride channel blocker. Anti-cancer activity.
|
-
- HY-125098
-
-
- HY-17435
-
|
4'-Demethylepipodophyllotoxin
4'-O-demethylepipodophyllotoxin; 4'-DMEP
|
Microtubule/Tubulin
|
Cancer
|
|
4'-Demethylepipodophyllotoxin(4'-DMEP) is a key intermediate compound for the preparation of podophyllotoxin-type anti-cancer drugs; a potent inhibitor of microtubule assembly.
|
-
- HY-126482
-
|
Telomerase-IN-2
|
Telomerase
|
Cancer
|
|
Telomerase-IN-2 is a telomerase inhibitor, and inhibits telomerase activity by decreasing expression of dyskerin, with an IC50 of 0.89 µM. Anti-cancer activity.
|
-
- HY-126330
-
|
SS-208
|
HDAC
|
Cancer
|
|
SS-208 is a selective HDAC6 inhibitor, with an IC50 of 12 nM. SS-208 possesses anti-tumor activity in melanoma.
|
-
- HY-N6811
-
|
1-Octacosanol
|
Others
|
Others
|
|
1-Octacosanol is a straight-chain aliphatic 28-carbon fatty alcohol with well-known anti-fatigue function.
|
-
- HY-N0234
-
|
Bavachinin
7-O-Methylbavachin; Bavachinin A
|
Others
|
Inflammation/Immunology
|
|
Bavachinin(7-O-Methylbavachin) is a natural compound isolated from the Chinese herb Fructus Psoraleae;has potent anti-angiogenic activity.
|
-
- HY-17480
-
|
Bendazac
|
Others
|
Inflammation/Immunology
|
|
Bendazac is an oxyacetic acid with anti-inflammatory, antinecrotic, choleretic and antilipidaemic properties. Bendazac acts by preventing protein denaturation and delays the cataractogenic process.
|
-
- HY-135301
-
-
- HY-124781
-
|
ML406
|
Bacterial
Antibiotic
|
Infection
|
|
ML406 is a small molecule probe that shows anti-tubercular activity via MtbbioA (DAPA synthase) enzyme inhibition with an IC50 of 30 nM.
|
-
- HY-136437
-
-
- HY-N2077
-
-
- HY-N5015
-
|
Rosmanol
|
Others
|
Inflammation/Immunology
Cancer
|
|
Rosmanol could inhibit the oxidation of low density lipoprotein (LPL) and significantly inhibit lipopolysaccharide induced iNOS and COX-2 expression, with anti-inflammatory effect.
|
-
- HY-N4277
-
|
Methyl protogracillin
NSC-698793
|
Others
|
Cancer
|
|
Methyl protogracillin (NSC-698793), isolated from the roots of Dioscorea opposite Thunb, exhibits strong anti-cancer activity.
|
-
- HY-N0415
-
-
- HY-N0708
-
-
- HY-N3049
-
-
- HY-N2601
-
-
- HY-N1433
-
-
- HY-B0433A
-
|
Quinine hydrochloride dihydrate
|
Parasite
|
Infection
|
|
Quinine Hydrochloride Dihydrate is a natural white crystalline alkaloid having antipyretic (fever-reducing), antimalarial, analgesic (painkilling), anti-inflammatory properties and a bitter taste.
|
-
- HY-13065
-
|
Isobavachalcone
Corylifolinin; Isobacachalcone
|
Akt
Reactive Oxygen Species
Apoptosis
Autophagy
|
Cancer
|
|
Isobavachalcone (Corylifolinin) is derived from Psoralea corylifolia Linn. and is a potent inhibitor of Akt signaling pathway, which induces apoptosis in human cancer cells (Inhibits OVCAR-8 cell growth with an IC50 value of 7.92 μM). Isobavachalcone also induces Reactive Oxyen Species (ROS) generation in OVCAR-8 cells and has exhibit cancer anti-promotive and anti-proliferative activity.
|
-
- HY-B0968A
-
|
Trimetazidine
|
Autophagy
|
Cardiovascular Disease
|
|
Trimetazidine is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine is an effective antianginal agent and a cytoprotective drug, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine triggers autophagy. Trimetazidine is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor.
|
-
- HY-N2259
-
|
Curcumenol
(+)-Curcumenol
|
Cytochrome P450
|
Cancer
Inflammation/Immunology
Neurological Disease
|
|
Curcumenol ((+)-Curcumenol) is a potent CYP3A4 inhibitor with an IC50 of 12.6 μM, which is one of constituents in the plants of medicinally important genus of Curcuma zedoaria, with neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities. Curcumenol ((+)-Curcumenol) suppresses Akt-mediated NF-κB activation and p38 MAPK signaling pathway in LPS-stimulated BV-2 microglial cells.
|
-
- HY-W015818
-
|
2-Benzoxazolinone
2-Benzoxazolone; 1,3-Benzoxazol-2(3H)-one; 2-Hydroxybenzoxazole
|
Parasite
|
Infection
|
|
2-Benzoxazolinone is an anti-leishmanial agent with an LC50 of 40 μg/mL against L. donovani. A building block in chemical synthesis. 1,3-Benzoxazol-2(3H)-one derivatives have antimicrobial activity against a selection of Gram-positive, Gram-negative bacteria and yeasts. Derivatives as anti-quorum sensing agent.
|
-
- HY-119367
-
|
ODM-203
|
FGFR
VEGFR
|
Cancer
|
|
ODM-203 is a potent FGFR and VEGFR families inhibitor with IC50s of 11, 16, 6, 35 nM towards recombinant FGFR1, FGFR2, FGFR3 and FGFR4 as well as 26, 9, 5 nM towards VEGFR1, VEGFR2 and VEGFR3, respectively. ODM-203 exhibits strong anti-tumor activity and induces anti-tumor immunity.
|
-
- HY-N0482
-
-
- HY-N2500
-
|
Deoxypodophyllotoxin
|
Microtubule/Tubulin
Apoptosis
Autophagy
|
Infection
Cardiovascular Disease
|
|
Deoxypodophyllotoxin (DPT), a derivative of podophyllotoxin, is a lignan with potent antimitotic, anti-inflammatory and antiviral properties isolated from rhizomes of Sinopodophullumhexandrum (Berberidaceae). Deoxypodophyllotoxin, targets the microtubule, has a major impact in oncology not only as anti-mitotics but also as potent inhibitors of angiogenesis. Deoxypodophyllotoxin induces cell autophagy and apoptosis. Deoxypodophyllotoxin evokes increase of intracellular Ca 2+ concentrations in DRG neurons.
|
-
- HY-B0968
-
|
Trimetazidine dihydrochloride
|
Autophagy
|
Cardiovascular Disease
|
|
Trimetazidine dihydrochloride is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine dihydrochloride is an effective antianginal agent and a cytoprotective drug, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine dihydrochloride triggers autophagy. Trimetazidine dihydrochloride is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor.
|
-
- HY-N5004
-
-
- HY-N0136
-
|
Taxifolin
(+)-Dihydroquercetin; (+)-Taxifolin
|
Autophagy
Tyrosinase
|
Cancer
|
|
Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM.
|
-
- HY-W015084
-
|
β-Ionone
|
Apoptosis
|
Cancer
|
|
β-Ionone, isolated from plant oils, is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. Anti-cancer activity.
|
-
- HY-N0006
-
-
- HY-N2909
-
|
Aurantiamide
|
Others
|
Inflammation/Immunology
|
|
Aurantiamide is an orally active constituent of Portulaca oleracea L and has various biological activities, including antioxidant, antiplatelet, anti-inflammatory, and antitumor activities.
|
-
- HY-112675
-
-
- HY-N0556
-
|
Isoescin IA
|
HIV Protease
|
Infection
|
|
Isoescin IA is a triterpenoid saponin isolated from the seeds of Aesculus chinensis. Isoescin IA has anti-HIV-1 protease activity.
|
-
- HY-N2414
-
|
Periplogenin
|
Others
|
Inflammation/Immunology
|
|
Periplogenin is a naturally occurring furanocoumarin found in Angelica dahurica roots，with potent anti-psoriatic effects. Periplogenin induces adipocyte differentiation.
|
-
- HY-N5117
-
-
- HY-B2191
-
|
Sodium gualenate
Guaiazulenesulfonate sodium
|
Others
|
Inflammation/Immunology
|
|
Sodium gualenate (Guaiazulenesulfonate sodium) is a hydrophilic derivative of guaiazulene with excellent anti-inflammatory and wound-healing effects mainly used for the treatment of duodenal ulcer, gastric ulcer and gastritis.
|
-
- HY-B1378
-
-
- HY-14749A
-
-
- HY-N0834
-
-
- HY-17592A
-
|
Bithionol sulfoxide
|
Parasite
|
Cancer
|
|
Bithionol sulfoxide(Bitin-S) is a clinically approved anti-parasitic drug; has been shown to inhibit solid tumor growth in several preclinical cancer models.
|
-
- HY-N5007
-
|
Galgravin
|
Others
|
Cancer
|
|
Galgravin is an active compound in Nectandra megapotamica, with anti-inflammatory activity. Galgravin displays in vitro cytotoxic activity and induce apoptosis in leukemia cells.
|
-
- HY-B2188
-
-
- HY-A0110A
-
-
- HY-135732
-
|
SK33
|
Androgen Receptor
|
Cancer
|
|
SK33, a trifluoromethylated enobosarm analog, is a potent, and tissue selective anti-androgen. SK33reduces androgen receptor (AR) transcriptional activity.
|
-
- HY-17438
-
|
Cidofovir
GS 0504; HPMPC; (S)-HPMPC
|
CMV
|
Infection
Cancer
|
|
Cidofovir is an anti-CMV drug which can suppress CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription.
|
-
- HY-100635S
-
-
- HY-N0117
-
|
Indirubin
Couroupitine B; Indigo red; Indigopurpurin
|
Apoptosis
|
Cancer
|
|
Indirubin (Couroupitine B) is a purple 3,2- bisindole and a stable isomer of indigo isolated from Indigo naturalis (Apiaceae); anti-inflammatory and anticancer activities.
|
-
- HY-106579S
-
-
- HY-N6862
-
|
Lucideric acid A
|
MMP
|
Cancer
|
|
Lucideric acid A is a natural compound isolated from Ganoderma lucidum, inhibits PMA-induced MMP-9 activity, with anti-invasive effect on hepatoma cells.
|
-
- HY-N0009
-
|
Geniposide
|
Amyloid-β
Influenza Virus
|
Neurological Disease
|
|
Geniposide is an iridoid glucoside extracted from Gardenia jasminoides Ellis fruits; exhibits a varity of biological activities such as anti-diabetic, antioxidative, antiproliferative and neuroprotective activities.
|
-
- HY-N2270
-
-
- HY-N0697
-
-
- HY-N0021
-
-
- HY-19214
-
-
- HY-10790
-
-
- HY-136064
-
-
- HY-N2276
-
|
Nodakenetin
|
Others
|
Inflammation/Immunology
|
|
Nodakenetin, isolated from Angelica decursiva, possesses antioxidant anti-inflammatory activities. Nodakenetin has the potential to be an antiarthritic and nerve tonic.
|
-
- HY-N0263
-
|
Toosendanin
|
Others
|
Inflammation/Immunology
|
|
Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb et Zucc, possesses analgesic, insecticidal and anti-inflammatory activities.
|
-
- HY-117843
-
-
- HY-120327
-
|
KY-226
|
Phosphatase
|
Metabolic Disease
Neurological Disease
|
|
KY-226 is a potent, selective, orally active and allosteric protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 of 0.25 μM, and without PPARγ agonist activity. KY-226 exerts anti-diabetic and anti-obesity effects by enhancing insulin and leptin signaling, respectively. KY-226 also protects neurons from cerebral ischemic injury.
|
-
- HY-12404
-
|
Diminazene aceturate
Diminazene diaceturate
|
Parasite
Angiotensin-converting Enzyme (ACE)
|
Infection
Inflammation/Immunology
|
|
Diminazene aceturate (Diminazene diaceturate) is an anti-trypanosome agent for livestock. The main biochemical mechanism of the trypanocidal actions of Diminazene aceturate is by binding to trypanosomal kinetoplast DNA (kDNA) in a non-intercalative manner through specific interaction with sites rich in adenine-thymine base pairs. Diminazene aceturate is also an angiotensin-converting enzyme 2 (ACE2) activator and has strong and potent anti-inflammatory properties.
|
-
- HY-129601
-
|
MYCi975
NUCC-0200975
|
c-Myc
|
Cancer
Inflammation/Immunology
|
|
MYCi975 (NUCC-0200975) is an orally active MYC inhibitor, which disrupts MYC/MAX interaction, promotes MYC T58 phosphorylation and MYC degradation, and impairs MYC driven gene expression. MYCi975 (NUCC-0200975) exhibits potent anti-tumor efficacy with good tolerability, increases tumor immune cell infiltration, and sensitizes tumors to anti-PD1 immunotherapy.
|
-
- HY-107309
-
|
Scabioside C
|
Others
|
Cancer
|
|
Scabioside C is a main triterpenoid saponin for total secondary saponin (TSS). TSS, from A. raddeana, exhibits the potential anti-breast cancer effect.
|
-
- HY-B0580
-
|
Ketorolac
RS37619
|
COX
|
Inflammation/Immunology
|
|
Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2.
|
-
- HY-B1453
-
-
- HY-100857
-
|
PrPSc-IN-1
|
Others
|
Neurological Disease
|
|
PrPSc-IN-1 is a fluorescent probe, binds to the misfolded protein PrP Sc, inhibits its accumulation, with an IC50 of 1.6 μM. Anti-prion activity.
|
-
- HY-30235A
-
-
- HY-N6864
-
|
Isovanillic acid
3-Hydroxy-4-methoxybenzoic acid
|
Others
|
Inflammation/Immunology
|
|
Isovanillic acid (3-Hydroxy-4-methoxybenzoic acid) is a phenolic acid isolated from isolated from S. frutescens, with Anti-inflammatory activity.
|
-
- HY-77036
-
|
Furagin
Furazidine; Furazidin
|
Bacterial
|
Infection
|
|
Furagin, nitrofurantoin analog, is an anti-bacterial agent. Furagin is 2-substituted 5-nitrofuran, chemically and structurally similar to well-known antibacterial compound nitrofurantoin.
|
-
- HY-N3007
-
|
Naringenin chalcone
|
Others
|
Inflammation/Immunology
|
|
Naringenin chalcone is an intermediate in flavonol biosynthesis and is spontaneously metabolized into naringenin (NAR) by chalcone isomerase. Naringenin chalcone has anti-inflammatory and antiallergic activities.
|
-
- HY-N2628
-
|
Erigeroside
|
Others
|
Metabolic Disease
|
|
Erigeroside is as a derivatives of -glucose extracted from Satureja khuzistanica Jamzad. Erigeroside has good ability of anti-oxidation and scavenging oxidation free radical.
|
-
- HY-N0709
-
-
- HY-W028047
-
|
JFD01307SC
|
Bacterial
|
|
|
JFD01307SC is a glutamine synthetase inhibitor and anti-tuberculosis agent. JFD01307SC acts as a mimic of L-Glutamate and thus target enzymes involved in glutamine biosynthesis.
|
-
- HY-124632
-
|
WJ460
|
Others
|
Cancer
|
|
WJ460 is a potent myoferlin (MYOF) inhibitor, which interacts directly with MYOF and exerts anti-metastatic activity in the nanomolar range in breast cancer cells.
|
-
- HY-N5043
-
-
- HY-N2055
-
-
- HY-114415
-
|
AWZ1066S
|
Parasite
|
Infection
|
|
AWZ1066S is a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis, with an EC50 of 2.5 nM in cell assay.
|
-
- HY-N6860
-
|
Lucidenic acid C
|
MMP
|
Cancer
|
|
Lucidenic acid C is a natural compound isolated from Ganoderma lucidum, inhibits PMA-induced MMP-9 activity, with anti-invasive effect on hepatoma cells.
|
-
- HY-I1196
-
|
Sofosbuvir impurity L
|
HCV
|
Infection
|
|
Sofosbuvir impurity L, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity.
|
-
- HY-N5042
-
-
- HY-111927
-
|
Pilloin
|
Others
|
Cancer
Inflammation/Immunology
|
|
Pilloin, a flavonoid isolated from Marrubium cylleneum, exerts a cytotoxic action targeted at the transformed lymphoblasts. Pilloin also possesses anti-inflammatory activity.
|
-
- HY-N0105
-
-
- HY-B0055
-
|
Azulene
Cyclopentacycloheptene
|
HIV
|
Infection
|
|
Azulene (Cyclopentacycloheptene) is as an isomer of naphthalene with high anti-HIV activity. Azulene, isolated from the distillation of chamomile oil, is a scaffold in medicinal chemistry.
|
-
- HY-18719A
-
-
- HY-N3500
-
-
- HY-B0647
-
|
Butylphthalide
3-n-Butylphthalide; 3-Butylphthalide
|
Others
|
Neurological Disease
|
|
Butylphthalide(3-n-Butylphthalide) is an anti-cerebral-ischemia drug; first isolated from the seeds of celery, showed efficacy in animal models of stroke.
|
-
- HY-10564
-
-
- HY-30219
-
-
- HY-116514
-
-
- HY-136150
-
|
Methyl carnosate
|
Bacterial
|
Infection
|
|
Methyl camosate is a diterpene isolated from Salvia officinalis or Rosmarinus officinalis. Methyl camosate has potent antioxidant and anti-bacterial activity.
|
-
- HY-18719
-
-
- HY-126941
-
|
Hecogenin acetate
|
Opioid Receptor
|
Neurological Disease
|
|
Hecogenin acetate is a steroidal sapogenin-acetylated with anti-inflammatory and antinociceptive. Hecogenin acetate shows potential antihyperalgesic activity, inhibiting descending pain and acting in opioid receptors.
|
-
- HY-15005C
-
|
Sofosbuvir impurity A
|
HCV
|
Infection
|
|
Sofosbuvir impurity A, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity.
|
-
- HY-108261
-
|
Tomeglovir
BAY 38-4766
|
CMV
|
Infection
|
|
Tomeglovir is a potent anti-CMV agent, inhibiting processing of viral DNA-concatemers, with IC50s of 0.34 μM and 0.039 μM for HCMV and MCMV.
|
-
- HY-N6821
-
-
- HY-129057
-
-
- HY-103662
-
-
- HY-B1355A
-
-
- HY-13751
-
-
- HY-N0436
-
|
Engeletin
|
NF-κB
|
Infection
Inflammation/Immunology
|
|
Engeletin is a flavanonol glycoside isolated from hymenaea martiana, inhibits NF-κB signaling-pathway activation, and possesses anti-inflammatory, analgesic, diuresis, detumescence, and antibiosis effects.
|
-
- HY-128934
-
-
- HY-N6998
-
|
Paederosidic acid
|
Apoptosis
|
Cancer
|
|
Paederosidic acid is isolated from P. scandens with anticancer and anti‐inflammation activities. Paederosidic acid inhibits lung caner cells via inducing mitochondria-mediated apoptosis.
|
-
- HY-N0429
-
|
Diosbulbin B
|
Others
|
Cancer
|
|
Diosbulbin B is a diterpene lactone isolated from D. bulbifera L., with anti-tumor activity. Diosbulbin B can induce liver injury.
|
-
- HY-10561
-
|
RU 58841
PSK-3841; HMR-3841
|
Androgen Receptor
|
Endocrinology
|
|
RU 58841 (PSK-3841) is a specific androgen receptor antagonist or anti-androgen. RU 58841 (PSK-3841) has a dramatic effect on hair regrowth.
|
-
- HY-119850
-
|
Aladorian
ARM036
|
Others
|
Cardiovascular Disease
|
|
Aladorian (ARM036) is a benzothiazepine derivative, with anti-arrhythmia effect. Aladorian is used for the research of heart failure and catecholaminergic polymorphic ventricular tachycardia.
|
-
- HY-129181
-
|
FGFR4-IN-4
|
FGFR
|
Cancer
|
|
FGFR4-IN-4 (compound 693) is a FGFR4 inhibitor with anti-tumor activity, extracted from patent WO2018113584A1.
|
-
- HY-N0252
-
-
- HY-N2453
-
|
Convallatoxin
|
PPAR
NF-κB
P-glycoprotein
|
Cancer
Inflammation/Immunology
|
|
Convallatoxin is a cardiac glycoside isolated from Adonis amurensis Regel et Radde. Convallatoxin ameliorates colitic inflammation via activation of PPARγ and suppression of NF-κB. Convallatoxin is a P-glycoprotein (P-gp) substrate and recognized Val982 as an important amino acid involved in its transport. Convallatoxin is an enhancer of ligand-induced MOR endocytosis with high potency and efficacy. Anti-inflammatory and anti-proliferative properties.
|
-
- HY-N6703
-
|
ar-Turmerone
(+)-ar-Turmerone
|
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
ar-Turmerone ((+)-ar-Turmerone) is a major bioactive compound of the herb Curcuma longa with anti-tumorigenesis and anti-inflammatory activities. ar-turmerone ((+)-ar-Turmerone) activates apoptotic protein in human lymphoma U937 cells. ar-Turmerone ((+)-ar-Turmerone) exerts positive modulation on murine DCs, induces NSC proliferation and constitutes a promising therapeutic agent for various neurologic disorders.
|
-
- HY-N4150
-
|
Quercetagitrin
Quercetagetin-7-O-glucoside
|
Others
|
Inflammation/Immunology
|
|
Quercetagitrin (Quercetagetin-7-O-glucoside), isolated from the flowers of the African Marigold (Tagetes erecta), has anti-inflammatory activity.
|
-
- HY-N4194
-
|
Glabrone
|
PPAR
|
Metabolic Disease
|
|
Glabrone is an isoflavone isolated from Glycyrrhiza glabra roots. Glabrone exhibits anti-influenza activity and significant PPAR-γ ligand-binding activity.
|
-
- HY-N4146
-
-
- HY-15005B
-
|
Sofosbuvir impurity C
|
Others
|
Others
|
|
Sofosbuvir impurity C is an impurity of Sofosbuvir, Sofosbuvir is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.
|
-
- HY-N0102
-
-
- HY-W011303
-
|
Phytosphingosine
|
Apoptosis
|
Cancer
|
|
Phytosphingosine is a phospholipid and has anti-cancer activities. Phytosphingosine induces cell apoptosis via caspase 8 activation and Bax translocation in cancer cells.
|
-
- HY-16589
-
-
- HY-W019940
-
-
- HY-I0727
-
|
Sofosbuvir impurity E
|
Others
|
Others
|
|
Sofosbuvir impurity E is an impurity of Sofosbuvir, Sofosbuvir is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.
|
-
- HY-124669
-
|
RTC-30
|
Others
|
Cancer
|
|
RTC-30 is an optimized phenothiazine with anti-cancer potency. RTC-30 contains a hydroxylated linker (N) that confers increased oral bioavailability.
|
-
- HY-N0023
-
|
Cistanoside A
|
Others
|
Inflammation/Immunology
|
|
Cistanoside A is a phenylethanoid isolated from Cistanche deserticola, reduces NO accumulation, but shows no effect on iNOS mRNA, iNOS protein levels or iNOS activity. Anti-inflammatory effect.
|
-
- HY-I0515
-
|
Sofosbuvir impurity K
|
HCV
|
Infection
|
|
Sofosbuvir impurity K, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity.
|
-
- HY-N0153
-
-
- HY-100757
-
|
CPUY074020
|
Histone Methyltransferase
|
Cancer
|
|
CPUY074020 is a potent and oral bioavailable inhibitor of histone methyltransferase G9a, with an IC50 of 2.18 μM. CPUY074020 possesses anti-proliferative activity.
|
-
- HY-N7078
-
|
Spiculisporic acid
|
Others
|
Others
|
|
Spiculisporic acid is a γ-butenolide isolated from the cultue of Aspergillus sp. Spiculisporic acid is a microbial biosurfactant and has anti-oxidative stress actions.
|
-
- HY-I0512
-
|
Sofosbuvir impurity I
|
HCV
|
Infection
|
|
Sofosbuvir impurity I, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity.
|
-
- HY-I0513
-
|
Sofosbuvir impurity N
|
HCV
|
Others
|
|
Sofosbuvir impurity N, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity.
|
-
- HY-131096
-
-
- HY-N0248
-
|
Saikosaponin B2
|
HCV
|
Cancer
Infection
|
|
Saikosaponin B2 is an active component from Bupleurum kaoi root, acts as an entry inhibitor against HCV infection. Anti-cancer activity.
|
-
- HY-A0084
-
|
Procainamide hydrochloride
|
Autophagy
|
Cancer
|
|
Procainamide hydrochloride is an anti-arrhythmic agent and is used to treat cardiac arrhythmia; induces rapid block of the batrachotoxin(BTX)-activated sodium channels of the heart muscle and acts as antagonist to long gating closures.
|
-
- HY-N5037
-
|
Ilexoside D
|
Others
|
Cardiovascular Disease
|
|
Ilexoside D is isolated from the roots of Ilex pubescens Hook. et Arn. Ilexoside D has the anti-tissue factor activity as well as the antithrombotic activity.
|
-
- HY-I0719
-
|
Sofosbuvir impurity B
|
Others
|
Others
|
|
Sofosbuvir impurity B is an impurity of Sofosbuvir, Sofosbuvir is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.
|
-
- HY-I0938
-
|
Sofosbuvir impurity H
|
HCV
|
Infection
|
|
Sofosbuvir impurity H, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity.
|
-
- HY-N0252A
-
-
- HY-I0975
-
|
Sofosbuvir impurity J
|
HCV
|
Infection
|
|
Sofosbuvir impurity J, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity.
|
-
- HY-I0735
-
|
Sofosbuvir impurity M
|
HCV
|
Infection
|
|
Sofosbuvir impurity M, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity.
|
-
- HY-N0330
-
|
Momordin Ic
|
Apoptosis
|
Cancer
|
|
Momordin Ic is a principal saponin constituent of Fructus Kochiae, with with anti-cancer bioactivity. Momordin Ic induces apoptosis through oxidative stress-regulated mitochondrial dysfunction.
|
-
- HY-30152
-
-
- HY-126296
-
-
- HY-P1787
-
-
- HY-116856
-
-
- HY-128599
-
|
NMS-P515
|
PARP
|
Cancer
|
|
NMS-P515 is a potent, orally active and stereospecific PARP-1 inhibitor, with a Kd of 16 nM and an IC50 of 27 nM (in Hela cells). Anti-tumor activity.
|
-
- HY-124600
-
|
NVR 3-778
|
HBV
|
Infection
|
|
NVR 3-778 is a first-in-Class and oral bioavailable HBV CAM (capsid assembly modulator) belonging to the SBA (sulfamoylbenzamide) class, with anti-HBV activity.
|
-
- HY-13748
-
|
Silibinin
Silybin; Silibinin A; Silymarin I
|
Autophagy
Reactive Oxygen Species
|
Cancer
|
|
Silibinin (Silybin), an effective anti-cancer and chemopreventive agent, has been shown to exert multiple effects on cancer cells, including inhibition of both cell proliferation and migration.
|
-
- HY-B1046
-
-
- HY-I0723
-
|
Sofosbuvir impurity D
|
Others
|
Others
|
|
Sofosbuvir impurity D is an impurity of Sofosbuvir, Sofosbuvir is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.
|
-
- HY-N0011
-
-
- HY-N7025
-
-
- HY-I0406
-
|
Sofosbuvir impurity F
|
HCV
|
Infection
|
|
Sofosbuvir impurity F, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity.
|
-
- HY-109588
-
|
NITD-349
|
Bacterial
|
Infection
|
|
NITD-349 is an MmpL3 inhibitor that shows highly potent anti-mycobacterial activity with MIC50 of 23 nM against virulent Mycobacterium tuberculosis H37Rv.
|
-
- HY-129467
-
|
Minerval
2-Hydroxyoleic acid; 2-OHOA
|
Apoptosis
|
Cancer
|
|
Minerval (2-Hydroxyoleic acid) is a synthetic oleic acid (OA) derivative that binds to the plasma membrane and alters lipid organization. Minerval has anti-tumor effect.
|
-
- HY-N7225
-
|
Yuanhuacine
Gnidilatidin
|
Others
|
Cancer
|
|
Yuanhuacine (Gnidilatidin), a daphnane diterpenoid from the flowers of Daphne genkwa with extensive anti-tumor activity. Yuanhuacine is a DNA-damaging agent with orally active.
|
-
- HY-136552
-
|
β-Bisabolene
|
Others
|
Cancer
|
|
β-Bisabolene is a sesquiterpene isolated from opoponax (Commiphora guidotti). β-Bisabolene, an anti-cancer agent, can be used for the study of breast cancer.
|
-
- HY-15605
-
|
Encorafenib
LGX818
|
Raf
|
Cancer
|
|
Encorafenib (LGX818) is a highly potent BRAF inhibitor with selective anti-proliferative and apoptotic activity in cells expressing BRAF V600E (EC50=4 nM).
|
-
- HY-18295
-
-
- HY-114277A
-
|
AMG-510 racemate
|
Ras
|
Cancer
|
|
AMG-510 racemate is the racemate of AMG-510. AMG-510 is a potent, orally bioavailable, and selective KRAS G12C covalent inhibitor with anti-tumor activity.
|
-
- HY-I0408
-
|
Sofosbuvir impurity G
|
Others
|
Others
|
|
Sofosbuvir impurity G, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity.
|
-
- HY-114245
-
|
Se-Methylselenocysteine
Methylselenocysteine; Se-Methylseleno-L-cysteine
|
Apoptosis
|
Cancer
|
|
Se-Methylselenocysteine, a precursor of Methylselenol, has potent cancer chemopreventive activity and anti-oxidant activity. Se-Methylselenocysteine is orally bioavailable, and induces apoptosis.
|
-
- HY-N7176
-
|
Kaempferol 3-O-β-D-glucuronide
Kaempferol-3-glucuronide; Kaempferol-3-O-glucuronide
|
Interleukin Related
|
Inflammation/Immunology
|
|
Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-glucuronide), one conjugated kaempferol metabolite, has anti-inflammatory effect. Kaempferol 3-O-β-D-glucuronide significantly inhibits various pro-inflammatory mediators like IL-1β, NO, PGE2, and LTB4. Kaempferol 3-O-β-D-glucuronide upregulates the secretion of anti-inflammatory cytokine IL-10.
|
-
- HY-N4126
-
|
6-Demethoxytangeretin
|
ALK
|
Cancer
Inflammation/Immunology
Neurological Disease
|
|
6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa. 6-Demethoxytangeretin exerts anti-inflammatory activity and anti-allergic activity, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase (ALK) and mitogen-activated protein kinase (MAPK) pathways. 6-Demethoxytangeretin facilitates the CRE-mediated transcription associated with learning and memory in cultured hippocampal neurons.
|
-
- HY-N2406
-
-
- HY-N6871
-
-
- HY-119580
-
|
Leucocyanidin
|
Others
|
Inflammation/Immunology
|
|
Leucocyanidin is an active anti-ulcerogenic ingredient was extracted from unripe plantain banana. Leucocyanidin demonstrates a significant protective effect against Aspirin-induced erosions in rat models.
|
-
- HY-17393
-
-
- HY-128685
-
|
FD 12-9
Ac12Az9
|
P-glycoprotein
BCRP
|
Cancer
|
|
FD 12-9 is a flavonoid dimer, acts as a dual inhibitor of P-gp and BCRP, with EC50s of 285 nM and 0.9 nM, respectively. Anti-glioblastoma activity.
|
-
- HY-101354
-
-
- HY-W009208
-
-
- HY-N2083
-
|
Handelin
|
Others
|
Inflammation/Immunology
|
|
Handelin is a guaianolide dimer from Chrysanthemum boreale that has potent anti-inflammatory activity by down-regulating NF-κB signaling and pro-inflammatory cytokine production.
|
-
- HY-N6020
-
|
(-)-Butin
|
Others
|
Inflammation/Immunology
|
|
(-)-Butin is the S enantiomer of Butin. Butin is a major biologically active flavonoid isolated from the heartwood of Dalbergia odorifera, with strong antioxidant, antiplatelet and anti-inflammatory activities.
|
-
- HY-U00157
-
|
Meseclazone
W2395; NSC297623
|
Others
|
Inflammation/Immunology
|
|
Meseclazone (W2395;NSC297623) exhibits inhibitory potency of secondary phase ADP aggregation. Meseclazone possesses anti-inflammatory, analgesic and antipyretic activity.
|
-
- HY-U00054
-
-
- HY-109587
-
|
BM635
|
Bacterial
|
Infection
|
|
BM635 is a MmpL3 inhibitor with outstanding anti-mycobacterial activity. BM635 has an MIC50 of 0.12 μM against M. tuberculosis H37Rv.
|
-
- HY-108741A
-
-
- HY-12460
-
-
- HY-N6877
-
|
Purpurogallin carboxylic acid
|
Others
|
Cancer
|
|
Purpurogallin carboxylic acid, isolated from Macleaya microcarpa (Maxim.) Fedde, is an oxidation product of gallic acid in fermented tea. Purpurogallin carboxylic acid has anti-cancer activity.
|
-
- HY-N6647
-
-
- HY-124646
-
|
KIRA-7
|
IRE1
|
Inflammation/Immunology
|
|
KIRA-7, an imidazopyrazine compound, binds the IRE1α kinase (IC50 of 110 nM) to allosterically inhibit its RNase activity. KIRA-7 has an anti-fibrotic effect.
|
-
- HY-Z0548
-
-
- HY-125729
-
-
- HY-114162A
-
-
- HY-15307A
-
|
Belumosudil mesylate
KD025 mesylate; SLx-2119 mesylate
|
ROCK
|
Inflammation/Immunology
|
|
Belumosudil mesylate (KD025 mesylate) is a selective inhibitor of ROCK2 with IC50s of 105 nM and 24 µM for ROCK2 and ROCK1, respectively. Anti-fibrotic properties.
|
-
- HY-103088
-
-
- HY-113951
-
-
- HY-101312
-
-
- HY-N2518
-
-
- HY-N6637
-
|
Senecionine N-oxide
|
Others
|
Cancer
|
|
Senecionine n-oxide is the primary product of pyrrolizidine alkaloid biosynthesis in root cultures of Senecio vulgaris. Senecionine N-oxide has anti-cancer activity.
|
-
- HY-110322A
-
|
PPTN
|
P2Y Receptor
|
Inflammation/Immunology
|
|
PPTN is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a KB value of 434 pM. Anti-inflammatory and immune activity.
|
-
- HY-100556
-
|
Tie2 kinase inhibitor 1
|
Others
|
Cancer
|
|
Tie2 kinase inhibitor 1 (compound 5) is a potent, selective Tie2 kinase inhibitor with an IC50 of 250 nM. Tie2 kinase inhibitor 1 has anti-cancer activity.
|
-
- HY-100437
-
|
HA15
|
HSP
Autophagy
Apoptosis
|
Cancer
|
|
HA15 is a potent and specific inhibitor of ER chaperone BiP/GRP78/HSPA5, inhibits the ATPase activity of BiP, with anti-cancerous activity.
|
-
- HY-N6829
-
|
Retusin
Quercetin-3,3',4',7-tetramethylether
|
Others
|
Infection
Inflammation/Immunology
|
|
Retusin (Quercetin-3,3',4',7-tetramethylether), a natural compound isolated from the leaves of Talinum triangulare, possesses antiviral and anti-inflammatory activities.
|
-
- HY-N7067
-
|
Revaprazan hydrochloride
|
Bacterial
COX
|
Infection
|
|
Revaprazan hydrochloride is a novel acid pump antagonist (APA). Revaprazan hydrochloride reduces COX-2 expression and has significant anti-inflammatory actions activities in H. pylori infection.
|
-
- HY-114162
-
-
- HY-15307
-
|
Belumosudil
KD025; SLx-2119
|
ROCK
|
Inflammation/Immunology
|
|
Belumosudil (KD025) is a selective inhibitor of ROCK2 with IC50s of 105 nM and 24 µM for ROCK2 and ROCK1, respectively. Anti-fibrotic properties.
|
-
- HY-N5014
-
-
- HY-N1380
-
-
- HY-N7494
-
|
Pentacosane
|
Others
|
Cancer
|
|
Pentacosane is one of the major components in the acetone extract from Curcuma raktakanda and is also in the essential oil from the leaves of Malus domestica. Pentacosane exhibit anti-cancer activities.
|
-
- HY-101085
-
|
SKL2001
|
Wnt
β-catenin
|
Cancer
|
|
SKL2001 is an agonist of the Wnt/β-catenin pathway, with anti-cancer activity. SKL2001 stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction.
|
-
- HY-131274
-
|
Fexofenadine Impurity F
|
Others
|
Others
|
|
Fexofenadine Impurity F is the impurity of Fexofenadine. Fexofenadine, a H1R antagonist, is an anti-allergic agent used in seasonal allergic rhinitis and chronic idiopathic urticarial.
|
-
- HY-N2193
-
|
Hirsutine
|
Apoptosis
|
Cancer
Infection
|
|
Hirsutine, an indole alkaloid of Uncaria rhynchophylla, exhibits anti-cancer activity. Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity.
|
-
- HY-N5040
-
-
- HY-N2189
-
-
- HY-N0858
-
|
Gomisin G
|
HIV
|
Infection
|
|
Gomisin G is an ethanolic extract of the stems of Kadsura interior; exhibits potent anti-HIV activity with EC50 and therapeutic index (TI) values of 0.006 microgram/mL and 300, respectively.
|
-
- HY-P1757
-
-
- HY-N0124
-
|
Dioscin
Collettiside III; CCRIS 4123
|
Autophagy
Apoptosis
|
Cancer
|
|
Dioscin(CCRIS 4123; Collettiside III) is a natural steroid saponin derived from several plants, showing potent anti-cancer effect against a variety of tumor cell lines.
|
-
- HY-N2149A
-
-
- HY-13751A
-
-
- HY-B1051
-
|
Flumethasone
Flumetasone
|
Others
|
Inflammation/Immunology
|
|
Flumethasone is a corticosteroid for topical use, in combination with Clioquinol for the treatment of otitis externa and otomycosis. Flumethasone shows fully 420 times the potency of cortisone in an animal model for anti-inflammatory activity.
|
-
- HY-126331
-
-
- HY-N4136
-
|
Lonicerin
|
Bacterial
|
Infection
|
|
Lonicerin is an anti-algE (alginate secretion protein) flavonoid with inhibitory activity for P. aeruginosa. Lonicerin prevents inflammation and apoptosis in LPS-induced acute lung injury.
|
-
- HY-N2149
-
-
- HY-110244
-
|
Tilfrinib
|
Others
|
Cancer
|
|
Tilfrinib (compound 4f) is a potent and selective inhibitor of breast tumor kinase (Brk) with an IC50 of 3.15 nM, which displays anti-proliferative activity and acts as a promising antitumor agent.
|
-
- HY-P1599
-
-
- HY-N1382
-
|
Asperuloside
|
NO Synthase
|
Inflammation/Immunology
|
|
Asperuloside is an iridoid isolated from Hedyotis diffusa, with anti-inflammatory activity. Asperuloside inhibits inducible nitric oxide synthase (iNOS), suppresses NF-κB and MAPK signaling pathways.
|
-
- HY-N0622
-
-
- HY-101191
-
|
Ecteinascidin 770
Ecteinascidine 770; Et-770
|
Apoptosis
|
Cancer
|
|
Ecteinascidin 770 (ET-770) is a 1,2,3,4-tetrahydroisoquinoline alkaloid with potent anti-cancer activities; inhibits U373MG cells with an IC50 of 4.83 nM.
|
-
- HY-N2515
-
|
Ginsenoside Rk1
|
NF-κB
PI3K
JAK
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
Ginsenoside Rk1 is a unique component created by processing the ginseng plant (mainly Sung Ginseng, SG) at high temperatures.
Ginsenoside Rk1 has anti-inflammatory effect, suppresses the activation of Jak2/Stat3 signaling pathway and NF-κB.
Ginsenoside Rk1 has anti-tumor effect, antiplatelet aggregation activities, anti-insulin resistance, nephroprotective effect, antimicrobial effect, cognitive function enhancement, lipid accumulation reduction and prevents osteoporosis.
Ginsenoside Rk1 induces cell apoptosis by triggering intracellular reactive oxygen species (ROS) generation and blocking PI3K/Akt pathway.
|
-
- HY-N1372A
-
|
Fangchinoline
|
HIV
FAK
Apoptosis
Autophagy
|
Cancer
Infection
|
|
Fangchinoline is isolated from Stephania tetrandra with extensive biological activities, such as enhancing immunity, anti-inflammatory sterilization and anti-atherosclerosis. Fangchinoline, a novel HIV-1 inhibitor, inhibits HIV-1 replication by impairing gp160 proteolytic processing. Fangchinoline targets Focal adhesion kinase (FAK) and suppresses FAK-mediated signaling pathway in tumor cells which highly expressed FAK. Fangchinoline induces apoptosis and adaptive autophagy in bladder cancer.
|
-
- HY-112724
-
|
SHR0302
|
JAK
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
SHR0302 is a potent and orally active all members of the JAK family inhibitor, particularly JAK1. The selectivity of SHR0302 for JAK1 is >10-fold for JAK2, 77-fold for JAK3, 420-fold for Tyk2. SHR0302 inhibits JAK1-STAT3 phosphorylation and induces the apoptosis of hepatic stellate cells. SHR0302 has anti-proliferative and anti-inflammatory effects.
|
-
- HY-129611
-
|
Bromelain
|
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
Bromelain is an anti-inflammatory drug derived from pineapple stem that acts through down-regulation of plasma kininogen, inhibition of Prostaglandin E2 expression, degradation of advanced glycation end product receptors and regulation of angiogenic biomarkers as well as antioxidant action upstream in the COX-pathway. Bromelain exhibits various fibrinolytic, antiedematous, antithrombotic, and anti-inflammatory activities. Bromelain also possesses some anticancerous activities and promotes apoptotic cell death.
|
-
- HY-N0551
-
|
Wedelolactone
|
Caspase
Lipoxygenase
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
Wedelolactone, a natural product from Ecliptae herba, suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK Complex. Wedelolactone inhibits 5-lipoxygenase (5-Lox) (IC50~2.5 μM) activity by an oxygen radical scavenging mechanism. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Anti-cancer, anti-inflammatory, and antioxidant activities.
|
-
- HY-108485
-
|
Damnacanthal
|
Src
Apoptosis
Fungal
|
Cancer
Infection
Inflammation/Immunology
|
|
Damnacanthal is an anthraquinone isolated from the root of Morinda citrifolia. Damnacanthal is a highly potent, selective inhibitor of p56 lck tyrosine kinase activity. Natural Damnacanthal inhibits p56 lck autophosphorylation and phosphorylation of exogenous substrates with IC50s of 46 nM and 220 nM, respectively. Damnacanthal is a potent inducer of apoptosis with anticancer activity. Damnacanthal also has antinociceptive, anti-inflammatory effects in mice and anti-fungal activity against Candida albicans.
|
-
- HY-126350
-
|
CL2-SN-38
|
Drug-Linker Conjugates for ADC
|
Cancer
|
|
CL2-SN-38 is a part of the antibody drug conjugate (ADC), can conjugate with the anti-Trop-2-humanized antibody hRS7. SN-38 is a DNA topoisomerase I inhibitor. The anti-Trop-2 hRS7-CL2A-SN-38 ADC provides significant and specific antitumor effects against a range of human solid tumor types.
|
-
- HY-N6878
-
|
Cauloside D
|
Others
|
Inflammation/Immunology
|
|
Cauloside D is a triterpene glycoside isolated from Caulophyllum robustum Max. Cauloside D exerts anti-inflammatory effects through the inhibition of expression of iNOS and proinflammatory cytokines.
|
-
- HY-17043
-
-
- HY-N0786
-
|
Ginkgolide J
|
Others
|
Neurological Disease
|
|
Ginkgolide J is a main constituent of the non-flavone fraction of Ginkgo biloba with an IC50 range of 12-54 µM, has neuroprotective and anti neuronal apoptotic ability.
|
-
- HY-121418
-
|
Lusianthridin
|
c-Myc
|
Cancer
|
|
Lusianthridin, a pure compound from Dendrobium venustum, have an anti-migratory effect. Lusianthridin enhances c-Myc degradation through the inhibition of Src-STAT3 signaling.
|
-
- HY-N1429
-
-
- HY-16679
-
|
Helioxanthin derivative 5-4-2
Helioxanthin 5-4-2
|
HBV
|
Infection
|
|
Helioxanthin derivative 5-4-2 is an analogue of helioxanthin, exhibites significant in vitro anti-HBV activity with EC50 of 0.08 uM in HepG2.2.15 cells.
|
-
- HY-13324
-
|
Bardoxolone methyl
RTA 402; NSC 713200; CDDO Methyl ester
|
Keap1-Nrf2
Autophagy
Apoptosis
Ferroptosis
|
Cancer
|
|
Bardoxolone methyl (NSC 713200; RTA 402; CDDO Methyl ester) is a synthetic triterpenoid compound with potential antineoplastic and anti-inflammatory activities, acting as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway.
|
-
- HY-N0795
-
-
- HY-128669
-
|
Abemaciclib Metabolites M2
|
CDK
|
Cancer
|
|
Abemaciclib Metabolites M2 is a metabolite of abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s in the range of 1-3 nM. Anti-cancer activity.
|
-
- HY-135654
-
-
- HY-U00367
-
-
- HY-100597
-
|
Saponins
Saponin
|
Others
|
Inflammation/Immunology
|
|
Saponins are a class of chemical compounds of glycosides found in particular abundance in various plant species. In plants, saponins may serve as anti-feedants, and to protect the plant against microbes and fungi.
|
-
- HY-108059
-
-
- HY-A0213A
-
|
Tiludronate disodium
Tiludronic Acid disodium
|
Others
|
Inflammation/Immunology
|
|
Tiludronate disodium (Tiludronic Acid disodium) is a new bisphosphonate, which prevents postmenopausal bone loss. Tiludronate disodium (Tiludronic Acid disodium) presents antiresorptive and anti-inflammatory properties.
|
-
- HY-114483
-
|
AES-135
|
HDAC
|
Cancer
|
|
AES-135 is a potent HDAC inhibitor, inhibits HDAC3, HDAC6, HDAC11 with IC50s of 654, 190, and 636 nM, respectively. Anti-tumor activity.
|
-
- HY-N1109
-
|
Uvaol
|
Others
|
Inflammation/Immunology
|
|
Uvaol, a triterpene present in olives and virgin olive oil, possesses anti-inflammatory properties and antioxidant effects. Uvaol attenuates pleuritis and eosinophilic inflammation in ovalbumin-induced allergy in mice.
|
-
- HY-108060
-
|
Valopicitabine
NM283
|
HIV
|
Infection
|
|
Valopicitabine (NM283), an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine, acts as a promising antiviral agent for reasearch of chronic HCV infection.
|
-
- HY-N2543
-
|
Damascenone
(E/Z)-Damascenone
|
NF-κB
|
Inflammation/Immunology
|
|
Damascenone ((E/Z)-Damascenone) is an active compound of Epipremnum pinnatum with anti-inflammatory activity. Damascenone is a mixture complex of E-isomer-Damascenone and Z-isomer Damascenone.
|
-
- HY-108570
-
|
AUDA
|
Epoxide Hydrolase
|
Inflammation/Immunology
|
|
AUDA (compound 43) is a potent soluble epoxide hydrolase (sEH) inhibitor with IC50s of 18 and 69 nM for the mouse and human sEH, respectively. AUDA has anti-inflammatory activity.
|
-
- HY-18342
-
|
Diflunisal
MK-647
|
COX
|
Inflammation/Immunology
Cancer
|
|
Diflunisal (MK-647) is a salicylate derivative with nonsteroidal anti-inflammatory and uricosuric properties, which is used alone as an analgesic and in rheumatoid arthritis patients. The mechanism of action of diflunisal is as a Cyclooxygenase (COX) Inhibitor.
|
-
- HY-N3386
-
|
Licoricone
|
Bacterial
|
Infection
|
|
Licoricone is an flavonoid extracted from licorice, exhibits anti-helicobacter pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains.
|
-
- HY-N2432
-
|
Paederoside
|
HBV
|
Cancer
Infection
|
|
Paederoside is a monoterpene S-methyl thiocarbonate isolated from Paederia pertomentosa. Paederoside shows a high anti-tumor promoting activity against the Epstein-Barr virus activation.
|
-
- HY-15230
-
-
- HY-B1130
-
|
Isoxicam
|
COX
|
Inflammation/Immunology
|
|
Isoxicam is an orally active, long-acting, non-steroidal anti-inflammatory agent for the research of arthritis. Isoxicam is a nonselective inhibitor of COX-1 and COX-2.
|
-
- HY-N0564
-
-
- HY-N0824
-
|
Syringin
Eleutheroside B
|
Autophagy
|
Cardiovascular Disease
|
|
Syringin is a main bioactive phenolic glycoside in Acanthopanax senticosus, with anti-osteoporosis activity. Syringin prevents cardiac hypertrophy induced by pressure overload through the attenuation of autophagy.
|
-
- HY-N1200
-
-
- HY-129188
-
|
CCT369260
|
Bcl-2 Family
|
Cancer
|
|
CCT369260 (compound 1) is an orally avtive B-cell lymphoma 6 (BCL6) inhibitor with anti-tumor activity. CCT369260 (compound 1) exhibits a IC50 of 520 nM.
|
-
- HY-N2027
-
-
- HY-N2473
-
-
- HY-B2175
-
|
Aspirin Aluminum
Aluminum diacetylsalicylate
|
Others
|
Inflammation/Immunology
|
|
Aspirin Aluminum is a novel intermolecular compound which can inhibit gastrointestinal mucosal disorders induced by NSAIDs (non-steroidal anti-inflammatory agents) extracted from patent WO 2010064441 A1.
|
-
- HY-N6919
-
|
Cauloside C
|
Others
|
Inflammation/Immunology
|
|
Cauloside C is a triterpene glycoside isolated from Caulophyllum robustum Max. Cauloside C exerts anti-inflammatory effects through the inhibition of expression of iNOS and proinflammatory cytokines.
|
-
- HY-N1375
-
|
Qingyangshengenin
|
Others
|
Cancer
|
|
Qingyanshengenin (NSC 379666; compound 2), a pregnane glycoside, is a C21 steroidal aglycone isolated from the root of Cynanchumot ophyllum (Asclepiadaceae). Qingyanshengenin has anti-cancer activity.
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- HY-N0099
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Astragaloside A
Astramembrannin I; Astragalin A
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Apoptosis
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Cardiovascular Disease
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Astragaloside A (Astramembrannin I; Astragalin A) is a saponin isolated from the root of Astragalus membranaceus. Astragaloside A exerts protective effect on cardiomyocytes and has hepato-protective, anti-oxidation activities.
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- HY-N3115
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Palbinone
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Others
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Inflammation/Immunology
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Palbinone is a terpenoid isolated from the roots of Paeonia albiflora Pallas, potently inhibits 3α-hydroxysteroid dehydrogenase (3α-HSD), with an IC50 of 46 nM. Anti-inflammatory activity.
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- HY-B1616
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- HY-111343
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ONC212
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Apoptosis
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Cancer
Endocrinology
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ONC212, a fluorinated-ONC201 analogue, is a promising anti-cancer agent and also a selective agonist of GPR132. ONC212 also induces apoptosis.
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- HY-112732B
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Sparfosic acid trisodium
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Others
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Cancer
Metabolic Disease
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Sparfosic acid trisodium, is a potent inhibitor of aspartate transcarbamoyl transferase, with anti-tumor and antimetabolite activity. Aspartate transcarbamoyl transferase catalyzes the second step of de novo pyrimidine biosynthesis.
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- HY-P1104A
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FC131 TFA
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CXCR
HIV
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Infection
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FC131 TFA is a CXCR4 antagonist, inhibits [ 125I]-SDF-1 binding to CXCR4, with an IC50 of 4.5 nM. Anti-HIV activity.
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- HY-112606
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ML-290
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Others
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Others
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ML-290 is a first-in-class and potent relaxin/insulin-like family peptide receptor (RXFP1) agonist and activator of anti-fibrotic genes, with an EC50 of 94 nM.
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- HY-B0418A
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- HY-Y0148
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- HY-N2618
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3-O-Acetyloleanolic acid
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Apoptosis
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Cancer
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3-O-Acetyloleanolic acid (3AOA), an oleanolic acid derivative isolated from the seeds of Vigna sinensis K., induces in cancer and also exhibits anti-angiogenesis activity.
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- HY-N0737
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- HY-N1482
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Methyl palmitate
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Others
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Inflammation/Immunology
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Methyl palmitate, an acaricidal compound occurring in green walnut husks, inhibits phagocytic activity and immune response. Methyl palmitate also posseses anti-inflammatory and antifibrotic effects.
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- HY-N0399
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- HY-N2266
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- HY-32291
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Methyl L-pyroglutamate
(S)-Methyl 5-oxopyrrolidine-2-carboxylate; L-Pyroglutamic acid methyl ester
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Others
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Others
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Methyl L-pyroglutamate ((S)-Methyl 5-oxopyrrolidine-2-carboxylate;L-Pyroglutamic acid methyl ester) is isolated from P. oleracea and has anti-inflammatory activity.
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- HY-100599
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- HY-B0801A
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- HY-16680
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Helioxanthin 8-1
Helioxanthin analogue 8-1
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HBV
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Infection
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Helioxanthin 8-1 is an analogue of helioxanthin, exhibites significant in vitro anti-HBV/HCV/HSV-1/HIV activity with EC50 of >5/10/1.4/15 uM.
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-
- HY-B0138
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Ketorolac tromethamine salt
Ketorolac Tromethamine; Ketorolac tris salt; RS37619 tromethamine salt
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COX
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Inflammation/Immunology
|
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Ketorolac tromethamine salt (RS37619 tromethamine salt) is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2.
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- HY-N0738
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- HY-N1481
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Methyl linoleate
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Others
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Metabolic Disease
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Methyl linoleate, a major active constituent of Sageretia thea fruit (HFSF), is a major anti-melanogenic compound. Methyl linoleate downregulates microphthalmia-associated transcription factor (MITF) and tyrosinase-related proteins.
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-
- HY-126294
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JAK1-IN-7
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JAK
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Inflammation/Immunology
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JAK1-IN-7 is a Janus-associated kinase 1 (JAK1) inhibitor extracted from patent WO2018134213A1, Example 63, has an anti-inflammatory effect.
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- HY-N0097
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Guanosine
DL-Guanosine; Vernine
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HSV
Endogenous Metabolite
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Infection
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Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity.
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- HY-15356
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