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Results for "

Anti-angiogenesis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (12) Aurora Kinase (1) Autophagy (1) Bacterial (2) c-Fms (1) c-Kit (1) Endogenous Metabolite (1) FAK (1) FGFR (1) HCV (1) HDAC (2) HIV (3) HIV Protease (3) Interleukin Related (2) Microtubule/Tubulin (8) MMP (3) NAMPT (1) P-glycoprotein (1) PARP (1) PDGFR (1) PERK (1) PPAR (1) PROTACs (2) Raf (1) Reactive Oxygen Species (4) ROR (1) SARS-CoV (3) SRPK (1) TAM Receptor (1) VEGFR (7)
By Research Areas:	Cancer (31) Cardiovascular Disease (4) Infection (5) Inflammation/Immunology (3) Neurological Disease (3)

Inhibitors & Agonists

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N7449

Neamine	Bacterial	Infection Cardiovascular Disease Neurological Disease Cancer
Neamine, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine is an anti-angiogenesis agent targeting angiogenin. Neamine has potent antibacterial, antitumor and neuroprotective activities .

HY-144817

Tubulin inhibitor 27	Microtubule/Tubulin	Cancer
Tubulin inhibitor 27 (DYT-1) is a tubulin polymerisation inhibitor with an IC₅₀ of 25.6 µM. Tubulin inhibitor 27 shows anti-angiogenesis and antitumor activities .

HY-144331

Antitumor agent-42	Microtubule/Tubulin Apoptosis	Cancer
Antitumor agent-42 (Compound 15h) is a bifunctional agent exhibiting both tubulin polymerized inhibition and NO-releasing activities, resulting in potent anti-angiogenesis, colony formation inhibition, cell cycle arrest and apoptosis induction effects .

HY-115349

Neamine tetrahydrochloride	Bacterial	Infection Neurological Disease Cancer
Neamine tetrahydrochloride, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine tetrahydrochloride is an anti-angiogenesis agent targeting angiogenin. Neamine tetrahydrochloride has potent antibacterial, antitumor and neuroprotective activities .

HY-144797

Tubulin inhibitor 22	Microtubule/Tubulin	Cancer
Tubulin inhibitor 22 (compound 4c) is a potent inhibitor of tubulin with anti-angiogenesis and anti-cancer properties. Tubulin inhibitor 22 arrests MGC-803 cell cycle at G2/M phase. Tubulin inhibitor 22 dose-dependently causes Caspase-induced apoptosis of MGC-803 cells through mitochondrial dysfunction .

HY-13718

Oglufanide H-Glu-Trp-OH; L-Glutamyl-L-tryptophan	VEGFR HCV Endogenous Metabolite	Infection Cardiovascular Disease Inflammation/Immunology Cancer
Oglufanide (H-Glu-Trp-OH) is a dipeptide immunomodulator isolated from calf thymus. Oglufanide inhibits vascular endothelial growth factor (VEGF). Oglufanide can stimulate the immune response to hepatitic C virus (HCV) and intracellular bacterial infections. Oglufanide shows antitumor and anti-angiogenesis activities .

HY-146160

PARP-1/HDAC-IN-1	PARP HDAC	Cancer
PARP-1/HDAC-IN-1 is a PARP-1/HDAC6 dual targeting inhibitor with IC₅₀s of 68.90 nM and 510 nM, respectively. PARP-1/HDAC-IN-1 displays remarkable anticancer, anti-migration and anti-angiogenesis activities .

HY-128580

FAK inhibitor 2 1 Publications Verification	FAK	Cancer
FAK inhibitor 2 is a potent focal adhesion kinase (FAK) inhibitor with an IC₅₀  of 0.07 nM, with antitumor and anti-angiogenesis activities .

HY-116856

SRPKIN-1 4 Publications Verification	SRPK	Cardiovascular Disease Cancer
SRPKIN-1 is a covalent and irreversible SRPK1/2 inhibitor with IC₅₀s of 35.6 and 98 nM, respectively. Anti-angiogenesis effect .

HY-N2618

3-O-Acetyloleanolic acid	Apoptosis	Cancer
3-O-Acetyloleanolic acid (3AOA), an oleanolic acid derivative isolated from the seeds of Vigna sinensis K., induces in cancer and also exhibits anti-angiogenesis activity .

HY-N6892

3'-O-Acetylhamaudol	Others	Cancer
3'-O-Acetylhamaudol, isolated from Angelica polymorpha, exhibits anti-tumor activity through dual actions, anti-angiogenesis and intestinal intraepithelial lymphocyte activation .

HY-104075

R916562	TAM Receptor VEGFR	Cancer
R916562 is an orally active and selective Axl/VEGF-R2 inhibitor with IC₅₀s of 136 nM and 24 nM, respectively. R916562 has anti-angiogenesis and anti-metastasis .

HY-126940

Furanodiene	Reactive Oxygen Species P-glycoprotein Apoptosis	Cancer
Furanodiene is a natural terpenoid isolated from Rhizoma Curcumae. Furanodiene plays anti-cancer effects through anti-angiogenesis and inducing ROS production, DNA strand breaks and apoptosis. Furanodiene suppresseed efflux transporter Pgp (P-glycoprotein) function and reduced Pgp protein level .

HY-146778

Tubulin inhibitor 25	Microtubule/Tubulin	Cancer
Tubulin inhibitor 25 is a potent tubulin inhibitor with an IC₅₀ value of 0.98 μM. Tubulin inhibitor 25 exhibits remarkable activity against cancer cell line HT29. Tubulin inhibitor 25 displays the potent inhibition on cell migration and tube formation that contributes to the anti-angiogenesis .

HY-101990

IMS2186	Others	Others
IMS2186 is an antichoroidal neovascularization (CNV) reagent. IMS2186 can arrest cancer cell cycle in G2/M phase, thus exerting anti-proliferation and anti-angiogenesis effects. IMS2186 has no intraocular toxicity and reduces the amount of eye leakage and diseased cells .

HY-B0689

Indinavir MK-639 free base; L-735524 free base	HIV HIV Protease Apoptosis MMP SARS-CoV	Inflammation/Immunology Cancer
Indinavir (MK-639 free base) is an orally active and selective HIV-1 protease inhibitor with a K_i of 0.54 nM for PR. Indinavir exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir is also a SARS-CoV 3CL ^pro inhibitor .

HY-B0689A

Indinavir sulfate 5+ Cited Publications MK-639; L735524	HIV HIV Protease SARS-CoV Apoptosis MMP	Infection Cancer
Indinavir sulfate (MK-639) is an orally active and selective HIV-1 protease inhibitor with a K_i of 0.54 nM for PR. Indinavir sulfate exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir sulfate is also a SARS-CoV 3CL ^pro inhibitor .

HY-146505

Tubulin polymerization-IN-6	Microtubule/Tubulin Apoptosis Reactive Oxygen Species	Cancer
Tubulin polymerization-IN-6 (compound 5f) is a potent tubulin polymerization inhibitor, with an IC₅₀ of 1.09 μM. Tubulin polymerization-IN-6 inhibits cell migration and tube formation and contributes to the anti-angiogenesis. Tubulin polymerization-IN-6 can greatly inhibit tumor growth on HT29 xenograft Balb/c nude mice .

HY-149920

Anticancer agent 98	Microtubule/Tubulin	Cancer
Anticancer agent 98 (compound 12k) is a microtubule/tubulin-polymerization inhibitor (K_d=16.9 μM). Anticancer agent 98 exerts antiproliferative potency against tumor cells, exhibits anti-angiogenesis effect in vitro. Anticancer agent 98 exhibits good human and mouse liver microsomes stability with both t_1/2>300 min .

HY-B0689B

Indinavir sulfate ethanolate MK-639 ethanolate; L735524 ethanolate	Apoptosis MMP HIV HIV Protease SARS-CoV	Infection Cancer
Indinavir sulfate ethanolate (MK-639 ethanolate) is an orally active and selective HIV-1 protease inhibitor with a K_i of 0.54 nM for PR. Indinavir sulfate ethanolate exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir sulfate ethanolate is also a SARS-CoV 3CL ^pro inhibitor .

HY-W440983

1-Stearoyl-2-docosahexaenoyl-sn-glyerco-3-phosphocholine SDPC; DHA-PC; 18:0/22:6 PC	PPAR	Cardiovascular Disease Cancer
1-Stearoyl-2-docosahexaenoyl-sn-glyerco-3-phosphocholine (SDPC; DHA-PC) is a new generation of omega-3 lipids, which contains an ester bond linking DHA at the sn-2 position of phospholipid. 1-Stearoyl-2-docosahexaenoyl-sn-glyerco-3-phosphocholine exerts anti-angiogenesis effect through activating PPARγ. 1-Stearoyl-2-docosahexaenoyl-sn-glyerco-3-phosphocholine significantly declines the proliferation, migration, tube formation of human umbilical vein endothelial cells. 1-Stearoyl-2-docosahexaenoyl-sn-glyerco-3-phosphocholine has the potential for anti-tumor angiogenesis research .

HY-N0155

Nobiletin Maximum Cited Publications 16 Publications Verification	ROR Reactive Oxygen Species Apoptosis Autophagy	Neurological Disease Inflammation/Immunology Cancer
Nobiletin is a poly-methoxylated flavone from the citrus peel that improves memory loss. Nobiletin is a retinoid acid receptor-related orphan receptors (RORs) agonist. Nobiletin can reduce reactive oxygen species (ROS) levels in differentiated C2C12 myotubes and has anti-inflammation and anti-cancer properties, including anti-angiogenesis, anti-proliferation, anti-metastasis and induced apoptosis .

HY-162319

Tubulin/HDAC-IN-4	Apoptosis HDAC Microtubule/Tubulin Reactive Oxygen Species	Cancer
Tubulin/HDAC-IN-4 (compound 9n) is a dual Tubulin and HDAC inhibitor with IC₅₀ values of 0.73, 0.43, 0.62, 2.34 µM for HDAC1, HDAC2, HDAC6, HDAC7, respectively. Tubulin/HDAC-IN-4 inhibits the tubulin polymerization by targeting the colchicine binding site. Tubulin/HDAC-IN-4 induces apoptosis and cell cycle arrest at G2/M phase. Tubulin/HDAC-IN-4 induces a significant elevation of intracellular ROS levels. Tubulin/HDAC-IN-4 shows anti-angiogenesis activity and anticancer activity .

HY-10080

Teglarinad chloride GMX1777; EB-1627	NAMPT	Cancer
Teglarinad chloride (GMX1777) is a proagent of GMX1778 (a nicotinamide phosphoribosyl transferase inhibitor). Teglarinad chloride exhibits antitumor activity in mice can be attributed to inhibition of NAMPT. Teglarinad chloride also enhances radiation efficacy, mediated by interference with DNA repair and antiangiogenesis .

HY-108933

JK-P3	VEGFR FGFR	Cancer
JK-P3 is a potent and pan VEGFR2 inhibitor, with IC₅₀s of 7.83 μM, 27 μM and 5.18 μM for VEGFR2, FGFR1 and FGFR3, respectively. JK-P3 can inhibit VEGF-A-stimulated VEGFR2 activation and intracellular signalling, also inhibits endothelial monolayer wound closure and angiogenesis, as well as fibroblast growth factor receptor kinase activity in vitro. JK-P3 has anti-angiogenic activity .

HY-146368

PROTAC VEGFR-2 degrader-1	PROTACs VEGFR	Cancer
PROTAC VEGFR-2 degrader-1（PROTAC-1）, a PROTAC VEGFR-2 degrader, exhibits little VEGFR-2 inhibition (IC₅₀> 1 μM) and anti-proliferative activity against EA.hy926 cells (IC₅₀> 100 μM) .

HY-146369

PROTAC VEGFR-2 degrader-2	PROTACs VEGFR	Cancer
PROTAC VEGFR-2 degrader-2（PROTAC-4）, a PROTAC VEGFR-2 degrader, exhibits little VEGFR-2 inhibition (IC₅₀> 1 μM) and anti-proliferative activity against EA.hy926 cells (IC₅₀> 100μM) .

HY-18318

Takeda-6D	Raf VEGFR PERK	Cancer
Takeda-6D (compound 6d) is an orally active and potent BRAF/VEGFR2 inhibitor, with IC₅₀ values of 7.0 and 2.2 nM, respectively. Takeda-6D shows antiangiogenesis by suppressing the VEGFR2 pathway in 293/KDR and VEGF-stimulated HUVEC cells.Takeda-6D shows significant suppression of ERK1/2 phosphorylation. Takeda-6D shows antitumor activity .

HY-15614

SC144 3 Publications Verification	Interleukin Related Apoptosis	Cancer
SC144 is a first-in-class, orally active gp130 (IL6-beta) inhibitor. SC144 binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes. SC144 shows potent inhibition of gp130 ligand-triggered signaling. SC144 induces apoptosis in human ovarian cancer cells .

HY-15614A

SC144 hydrochloride 3 Publications Verification	Interleukin Related Apoptosis	Cancer
SC144 hydrochloride is a first-in-class, orally active gp130 (IL6-beta) inhibitor. SC144 hydrochloride binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes. SC144 hydrochloride shows potent inhibition of gp130 ligand-triggered signaling. SC144 hydrochloride induces apoptosis in human ovarian cancer cells .

HY-124526

Chiauranib Ibcasertib; CS2164	VEGFR PDGFR c-Kit Aurora Kinase c-Fms	Cancer
Chiauranib (CS2164) is an orally active multi-target inhibitor against tumor angiogenesis. Chiauranib potently inhibits the angiogenesis-related kinases (VEGFR1, VEGFR2, VEGFR3, PDGFRα and c-Kit), mitosis-related kinase Aurora B, and chronic inflammation-related kinase CSF-1R, with IC₅₀ values ranging from 1-9 nM. Chiauranib has strongly anticancer effects .

HY-144818

Tubulin inhibitor 23	Apoptosis Microtubule/Tubulin	Cancer
Tubulin inhibitor 23 is a potent Tubulin inhibitor with an IC₅₀ of 4.8 µM. Tubulin inhibitor 23 induces cell apoptosis. Tubulin inhibitor 23 shows antiangiogenic activity in a dose-dependent manner. Tubulin inhibitor 23 has the potential for the research of leukaemia .

Oglufanide H-Glu-Trp-OH; L-Glutamyl-L-tryptophan	VEGFR HCV Endogenous Metabolite	Infection Cardiovascular Disease Inflammation/Immunology Cancer
Oglufanide (H-Glu-Trp-OH) is a dipeptide immunomodulator isolated from calf thymus. Oglufanide inhibits vascular endothelial growth factor (VEGF). Oglufanide can stimulate the immune response to hepatitic C virus (HCV) and intracellular bacterial infections. Oglufanide shows antitumor and anti-angiogenesis activities .

Neamine	Cardiovascular Disease Infection Classification of Application Fields Disease Research Fields	Bacterial
Neamine, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine is an anti-angiogenesis agent targeting angiogenin. Neamine has potent antibacterial, antitumor and neuroprotective activities .

Oglufanide H-Glu-Trp-OH; L-Glutamyl-L-tryptophan	Cardiovascular Disease Structural Classification Classification of Application Fields Animals Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	VEGFR HCV Endogenous Metabolite
Oglufanide (H-Glu-Trp-OH) is a dipeptide immunomodulator isolated from calf thymus. Oglufanide inhibits vascular endothelial growth factor (VEGF). Oglufanide can stimulate the immune response to hepatitic C virus (HCV) and intracellular bacterial infections. Oglufanide shows antitumor and anti-angiogenesis activities .

3-O-Acetyloleanolic acid	Triterpenes Classification of Application Fields Leguminosae Terpenoids Source classification Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Cancer	Apoptosis
3-O-Acetyloleanolic acid (3AOA), an oleanolic acid derivative isolated from the seeds of Vigna sinensis K., induces in cancer and also exhibits anti-angiogenesis activity .

3'-O-Acetylhamaudol	Callicarpa nudiflora Hook. et Arn. Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Plants Umbelliferae Disease Research Fields Cancer	Others
3'-O-Acetylhamaudol, isolated from Angelica polymorpha, exhibits anti-tumor activity through dual actions, anti-angiogenesis and intestinal intraepithelial lymphocyte activation .

Furanodiene	Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Curcuma longa Disease Research Fields Cancer Zingiberaceae	Reactive Oxygen Species P-glycoprotein Apoptosis
Furanodiene is a natural terpenoid isolated from Rhizoma Curcumae. Furanodiene plays anti-cancer effects through anti-angiogenesis and inducing ROS production, DNA strand breaks and apoptosis. Furanodiene suppresseed efflux transporter Pgp (P-glycoprotein) function and reduced Pgp protein level .

Nobiletin 15+ Cited Publications	Structural Classification Flavonoids Neurological Disease Classification of Application Fields Flavones Source classification Rutaceae Plants Inflammation/Immunology Disease Research Fields Citrus reticulata Blanco	ROR Reactive Oxygen Species Apoptosis Autophagy
Nobiletin is a poly-methoxylated flavone from the citrus peel that improves memory loss. Nobiletin is a retinoid acid receptor-related orphan receptors (RORs) agonist. Nobiletin can reduce reactive oxygen species (ROS) levels in differentiated C2C12 myotubes and has anti-inflammation and anti-cancer properties, including anti-angiogenesis, anti-proliferation, anti-metastasis and induced apoptosis .

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Anti-angiogenesis

Inhibitors & Agonists

Peptides

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Natural
Products