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Results for "

Antineoplastic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (9) Akt (2) Amylin Receptor (3) Anaplastic lymphoma kinase (ALK) (1) Androgen Receptor (2) Antibiotic (15) Antifolate (5) Apoptosis (57) Autophagy (37) Bacterial (10) Bcl-2 Family (3) Bcr-Abl (4) Biochemical Assay Reagents (1) Btk (1) c-Kit (3) c-Met/HGFR (19) Caspase (1) CD3 (2) CD38 (1) CDK (7) Cholecystokinin Receptor (1) Cholinesterase (ChE) (1) Complement System (1) COX (1) CTLA-4 (2) Cyclin G-associated Kinase (GAK) (2) Cytochrome P450 (1) Dipeptidyl Peptidase (2) DNA Alkylator/Crosslinker (16) DNA/RNA Synthesis (17) Drug Metabolite (2) Drug-Linker Conjugates for ADC (2) E1/E2/E3 Enzyme (2) E3 Ligase Ligand-Linker Conjugates (1) EGFR (10) Endogenous Metabolite (9) Epigenetic Reader Domain (1) Estrogen Receptor/ERR (2) Eukaryotic Initiation Factor (eIF) (2) FAK (2) Farnesyl Transferase (1) Ferroptosis (3) FGFR (4) FLT3 (3) Fungal (4) GnRH Receptor (1) HDAC (4) Histone Demethylase (4) Histone Methyltransferase (1) HIV (6) HMG-CoA Reductase (HMGCR) (3) HSP (1) HSV (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Influenza Virus (3) Interleukin Related (3) Isotope-Labeled Compounds (17) Keap1-Nrf2 (1) MDM-2/p53 (3) MEK (1) Methionine Adenosyltransferase (MAT) (1) MicroRNA (2) Microtubule/Tubulin (16) Mitochondrial Metabolism (1) Mitophagy (3) MMP (1) NAMPT (1) NF-κB (2) Notch (1) Nuclear Hormone Receptor 4A/NR4A (1) Nucleoside Antimetabolite/Analog (12) Orthopoxvirus (1) p38 MAPK (1) Parasite (7) PARP (2) PD-1/PD-L1 (2) PDGFR (3) Phosphatase (2) Phosphodiesterase (PDE) (1) PI3K (6) Proteasome (1) RAD51 (2) Raf (1) RAR/RXR (1) Ras (1) Reactive Oxygen Species (10) RET (2) Reverse Transcriptase (2) SARS-CoV (2) Sirtuin (2) Src (1) STAT (3) STING (1) TGF-beta/Smad (1) TGF-β Receptor (1) TNF Receptor (1) Topoisomerase (22) Trk Receptor (1) TRP Channel (1) VEGFR (1) VSV (1) Wnt (1) γ-secretase (1)
By Research Areas:	Cancer (286) Cardiovascular Disease (5) Endocrinology (6) Infection (18) Inflammation/Immunology (33) Metabolic Disease (11) Neurological Disease (6)
Click Chemistry:	Azide (1) Alkynes (1)

278

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-147245

Basroparib

STP1002
PARP Cancer

Basroparib is a potent poly (ADP-ribose) polymerase (PARP) inhibitor, with antineoplastic activity .
HY-145609

Debotansine

Others Inflammation/Immunology Cancer

Debotansine is a immunomodulator and antineoplastic .
HY-109140

Tuvatexib

Others Cancer

Tuvatexib is an antineoplastic agent .
HY-147248

Opadotina

Others Cancer

Opadotina is a small molecule of anvatabart opadotin. Opadotina shows antineoplastic activity .
HY-120098A

Vinleurosine sulfate

Others Cancer

Vinleurosine sulfate is an indole alkaloid with antineoplastic activity .
HY-132844

Tunlametinib

HL-085
c-Met/HGFR Cancer

Tunlametinib, an antineoplastic agent, is a tyrosine kinase inhibitor .
HY-N9271

Grifolin

Apoptosis Cancer

Grifolin is an antineoplastic agent can be isolated from the mushroom Albatrellus confluens and significantly induces apoptosis .

Basroparib STP1002	PARP	Cancer
Basroparib is a potent poly (ADP-ribose) polymerase (PARP) inhibitor, with antineoplastic activity .

Debotansine	Others	Inflammation/Immunology Cancer
Debotansine is a immunomodulator and antineoplastic .

Tuvatexib	Others	Cancer
Tuvatexib is an antineoplastic agent .

Opadotina	Others	Cancer
Opadotina is a small molecule of anvatabart opadotin. Opadotina shows *antineoplastic* activity .

Vinleurosine sulfate	Others	Cancer
Vinleurosine sulfate is an indole alkaloid with antineoplastic activity .

Tunlametinib HL-085	c-Met/HGFR	Cancer
Tunlametinib, an *antineoplastic* agent, is a tyrosine kinase inhibitor .

Grifolin	Apoptosis	Cancer
Grifolin is an antineoplastic agent can be isolated from the mushroom Albatrellus confluens and significantly induces apoptosis .

HY-147303

Sacibertinib	Trk Receptor EGFR	Cancer
Sacibertinib is a tyrosine kinase (Trk) inhibitor with EC₅₀ value of 110 nM and 244 nM for EGFR-TK phosphorylation and HER2, respectively. Antineoplastic activity .

HY-121401

Myrtenal (±)-Myrtenal	Others	Cancer
Myrtenal ((±)-Myrtenal) is a monoterpene that acts as an antineoplastic agent. Myrtenal inhibits liver cancer by preventing DEN-PB-induced upregulation of TNF-α protein expression.

HY-147258

Culmerciclib

Cyclin G-associated Kinase (GAK) Cancer

Culmerciclib is a cyclin dependent kinase (CDK) inhibitor, and has antineoplastic activity .
HY-147258A

Culmerciclib maleate

Cyclin G-associated Kinase (GAK) Cancer

Culmerciclib maleate is a cyclin dependent kinase (CDK) inhibitor, and has antineoplastic activity .
HY-116280

Aceratioside

Others Cancer

Aceratioside, a tetralin glucoside, is a weakly cytostatic constituent. Aceratioside is an antineoplastic agent .
HY-108610

(R)-Edelfosine

(R)-ET-18-OCH3
HIV Infection Cancer

(R)-Edelfosine ((R)-ET-18-OCH3) is a ether lipid analog with anti-HIV and antineoplastic activity .
HY-139412

Gilmelisib

PI3K Cancer

Gilmelisib is an antineoplastic. Gilmelisib is a PI3K inhibitor (IC₅₀ <1 nM for PI3K p110α) extracted from WO2017101847 A1, compound 1 .
HY-156641

Sontigidomide

Others Cancer

Sontigidomide (Compound 5) is an antineoplastic compound. Sontigidomide inhibits MOLM-13 cell proliferation more than 80% at 1 μM (3 days) .

Culmerciclib	Cyclin G-associated Kinase (GAK)	Cancer
Culmerciclib is a cyclin dependent kinase (CDK) inhibitor, and has *antineoplastic* activity .

Culmerciclib maleate	Cyclin G-associated Kinase (GAK)	Cancer
Culmerciclib maleate is a cyclin dependent kinase (CDK) inhibitor, and has *antineoplastic* activity .

Aceratioside	Others	Cancer
Aceratioside, a tetralin glucoside, is a weakly cytostatic constituent. Aceratioside is an antineoplastic agent .

(R)-Edelfosine (R)-ET-18-OCH3	HIV	Infection Cancer
(R)-Edelfosine ((R)-ET-18-OCH3) is a ether lipid analog with *anti-HIV* and antineoplastic activity .

Gilmelisib	PI3K	Cancer
Gilmelisib is an antineoplastic. Gilmelisib is a PI3K inhibitor (IC₅₀ <1 nM for PI3K p110α) extracted from WO2017101847 A1, compound 1 .

Sontigidomide	Others	Cancer
Sontigidomide (Compound 5) is an antineoplastic compound. Sontigidomide inhibits MOLM-13 cell proliferation more than 80% at 1 μM (3 days) .

HY-109146

Imifoplatin PT-112	Apoptosis DNA Alkylator/Crosslinker	Cancer
Imifoplatin (PT-112) is a platinum-based agent belonging to the phosphaplatin family. Imifoplatin exhibits antineoplastic activity .

HY-152830A

Adrixetinib TFA

Others Cancer

Adrixetinib (TFA) is an inhibitor of protein tyrosine kinase with antineoplastic activity .
HY-109185

Pelcitoclax

APG-1252
Bcl-2 Family Apoptosis Cancer

Pelcitoclax (APG-1252) is a potent Bcl-2/Bcl-xl inhibitor with antineoplastic and pro-apoptotic effects .

Adrixetinib TFA	Others	Cancer
Adrixetinib (TFA) is an inhibitor of protein tyrosine kinase with antineoplastic activity .

Pelcitoclax APG-1252	Bcl-2 Family Apoptosis	Cancer
Pelcitoclax (APG-1252) is a potent Bcl-2/Bcl-xl inhibitor with antineoplastic and pro-apoptotic effects .

HY-12289S

Defactinib-d6 VS-6063-d₆; PF-04554878-d₆	FAK Isotope-Labeled Compounds	Cancer
Defactinib-d6 is a deuterium labeled Defactinib (HY-12289). Defactinib is a novel FAK inhibitor with potential antiangiogenic and antineoplastic activities .

HY-P0058

Pramlintide	Amylin Receptor	Metabolic Disease Cancer
Pramlintide is a polypeptide analogue of human amylin. Pramlintide, an antidiabetic agent, is antineoplastic in colorectal cancer .

HY-P0058B

Pramlintide acetate	Amylin Receptor	Metabolic Disease Cancer
Pramlintide acetate is a polypeptide analogue of human amylin. Pramlintide acetate, an antidiabetic agent, is antineoplastic in colorectal cancer .

HY-13667

Levoleucovorin Calcium 2 Publications Verification Calcium levofolinate; CL307782	Antifolate	Cancer
Levoleucovorin Calcium (Calcium levofolinate), a levo isoform of Leucovorin Calcium (HY-13664), possesses antineoplastic effects. Levoleucovorin Calcium is also an augmentor of 5-fluorouracil (HY-90006) cytotoxicity against cancer .

HY-P0058A

Pramlintide TFA	Amylin Receptor	Metabolic Disease Cancer
Pramlintide TFA is a polypeptide analogue of human amylin. Pramlintide TFA, an antidiabetic agent, is antineoplastic in colorectal cancer .

HY-P990048

Muzastotug

CTLA-4 Cancer

Muzastotug is a humanized immunoglobulin G1-kappa, anti-CTLA4 monoclonal antibody. Muzastotug is an immunostimulant and antineoplastic .

Muzastotug	CTLA-4	Cancer
Muzastotug is a humanized immunoglobulin G1-kappa, *anti-CTLA4* monoclonal antibody. Muzastotug is an immunostimulant and antineoplastic .

HY-134008

Protoapigenone	Others	Cancer
Protoapigenone is an antineoplastic agent isolated from ferns. Protoapigenone has significant inhibitory activity against Hep G2, Hep 3B, MCF-7, A549 and MDAMB-231, with IC₅₀s values of 1.60, 0.23, 0.78, 3.88 and 0.27 μg/mL respectively .

HY-101820

Simotinib

EGFR Cancer

Simotinib is a selective, specific, and orally bioavailable EGFR tyrosine kinase inhibitor, with an IC₅₀ of 19.9 nM. Antineoplastic activities .

Simotinib	EGFR	Cancer
Simotinib is a selective, specific, and orally bioavailable EGFR tyrosine kinase inhibitor, with an IC₅₀ of 19.9 nM. Antineoplastic activities .

HY-101820A

Simotinib hydrochloride	EGFR	Cancer
Simotinib hydrochloride is a selective, specific, and orally bioavailable EGFR tyrosine kinase inhibitor, with an IC₅₀ of 19.9 nM. Antineoplastic activities .

HY-P990095

Vonsetamig

CD3 TNF Receptor Cancer

Vonsetamig is a humanised immunoglobulin G4-kappa, anti-TNFRSF17 and CD3E monoclonal antibody. Vonsetamig is an antineoplastic .
HY-155812

Tyrosine kinase-IN-6

c-Met/HGFR Cancer

Tyrosine kinase-IN-6 is a potent and promising RON splice variants inhibitor with anti-cancer and o?antineoplastic effects .

Vonsetamig	CD3 TNF Receptor	Cancer
Vonsetamig is a humanised immunoglobulin G4-kappa, *anti-TNFRSF17* and CD3E monoclonal antibody. Vonsetamig is an antineoplastic .

Tyrosine kinase-IN-6	c-Met/HGFR	Cancer
Tyrosine kinase-IN-6 is a potent and promising RON splice variants inhibitor with anti-cancer and o?antineoplastic effects .

HY-N2812

Epipodophyllotoxin acetate 4-O-Epipodophyllotoxinyl acetate	HSV VSV	Infection Cancer
Epipodophyllotoxin acetate (4-O-Epipodophyllotoxinyl acetate; compound 4) is a cyclolignan that exhibits antineoplastic and antiviral activities. Epipodophyllotoxin acetate inhibits HSV and VSV, with IC₅₀s of 0.2 and 0.1 μg/mL, respectively .

HY-138627A

AST5902 trimesylate	EGFR Drug Metabolite	Cancer
AST5902 trimesylate is the principal metabolite of Alflutinib (AST2818) both in vitro and in vivo. AST5902 trimesylate exerts antineoplastic activity. Alflutinib is an EGFR inhibitor .

HY-152852S

Mefatinib-d6 free base Mifanertinib-d₆	Isotope-Labeled Compounds c-Met/HGFR	Cancer
Mefatinib-d6 free base (Mifanertinib-d6) is the deuterium labeled Mefatinib. Mefatinib is a potent tyrosine kinase inhibitor with antineoplastic activity .

HY-P99628

Futuximab

EGFR Cancer

Futuximab is a chimeric monoclonal antibody targeting non-overlapping epitopes on EGFR. Futuximab has antineoplastic activity .

Futuximab	EGFR	Cancer
Futuximab is a chimeric monoclonal antibody targeting non-overlapping epitopes on EGFR. Futuximab has antineoplastic activity .

HY-120220

Piposulfan A-20968; Ancyte	Others	Cancer
Piposulfan (Ancyte) is a methanesulfonate, alkylating derivative of piperazine. Piposulfan has potential *antineoplastic* activity. Piposulfan can be used for the research of cancer .

HY-P990073

Davutamig REGN-5093	c-Met/HGFR	Cancer
Davutamig (REGN-5093) is a human immunoglobulin G4-kappa, *anti-MET* monoclonal antibody targeting two different nonoverlapping epitopes on MET. Davutamig is an antineoplastic .

HY-147407

Imbotolimod	Others	Cancer
Imbotolimod, immunoglobulin G1-kappa, is a humanized monoclonal antibody with *anti-ERBB2* and *antineoplastic* activity. Imbotolimod is a derivative of telratolimod .

HY-N11110

Inuviscolide	Apoptosis	Inflammation/Immunology Cancer
Inuviscolide is an apoptosis inducer. Inuviscolide can induce of G₂/M arrest in human melanoma cell lines. Inuviscolide exhibits antineoplastic and anti-inflammatory activities .

HY-17394

Cisplatin Maximum Cited Publications 383 Publications Verification cis-Platinum; CDDP; cis-Diaminodichloroplatinum	DNA Alkylator/Crosslinker Ferroptosis Autophagy	Cancer
Cisplatin (CDDP) is an antineoplastic chemotherapy agent by cross-linking with DNA and causing DNA damage in cancer cells. Cisplatin activates ferroptosis and induces autophagy .

HY-N10470

Bleomycin A5 1 Publications Verification Pingyangmycin	Apoptosis	Infection Inflammation/Immunology Cancer
Bleomycin A5 (Pingyangmycin) is an orally active glycopeptide antibiotics. Bleomycin A5 has a role as an antineoplastic agent, an apoptosis inducer and a bacterial metabolite .

HY-N12262

(+)-Epieudesmin	Bacterial	Infection Cancer
(+)-Epieudesmin is an antineoplastic agent. (+)-Epieudesmin has marginal cancer cell line inhibitory activities. (+)-Epieudesmin inhibits the growth of Gram-negative pathogen .

HY-103711

Estramustine	Microtubule/Tubulin	Cancer
Estramustine is an antineoplastic agent. Estramustine depolymerizes microtnbules by binding to tubulin 1, exhibits antimitotic activity with an IC₅₀ value of ~16 μM for mitosis of DU 145 cells. Estramustine blocks cells at mitosis in prostate tumor xenografts .

HY-108992

Deoxynyboquinone	Apoptosis Reactive Oxygen Species	Cancer
Deoxynyboquinone, an excellent NQO1 substrate, is a potent antineoplastic agent. Deoxynyboquinone induces apoptosis in cancer cell lines. Deoxynyboquinone kills cancer cells through oxidative stress and reactive oxygen species (ROS) formation .

HY-P990080

Sovipostobart	CTLA-4	Cancer
Sovipostobart is an immunoglobulin G1-kappa, *anti-CTLA-4* human monoclonal antibody with cleavable prodomain. Sovipostobart is an immunostimulant and antineoplastic .

HY-147877

Topoisomerase II inhibitor 12	Topoisomerase	Cancer
Topoisomerase II inhibitor 12 (Compound 8c) is a topoisomerase II (topo II) inhibitor, working as a DNA non-intercalator. Topoisomerase II inhibitor 12 shows antineoplastic activity .

HY-N10591

Bruceantarin

Others Cancer

Bruceantarin is a potent antineoplastic agent. Bruceantarin can be used for leukemia and breast cancer research .

Bruceantarin	Others	Cancer
Bruceantarin is a potent *antineoplastic* agent. Bruceantarin can be used for leukemia and breast cancer research .

HY-100620

RPR121056 APC	Topoisomerase Cholinesterase (ChE)	Cancer
RPR121056 (APC) is a metabolite of Irinotecan (CPT-11), which is generated by CYP3A4. Irinotecan (CPT-11) is an antineoplastic agent that inhibits topoisomerase type I, causing cell death, and is widely used in the treatment of colorectal cancer. Irinotecan also directly inhibits AChE .

HY-109198

Zandelisib ME-401; PWT-143	PI3K	Cancer
Zandelisib (ME-401) is a phosphatidylinositol 3-kinase (PI3K) inhibitor extracted from patent WO2019183226 A1, Compound Example 1. Zandelisib selectively inhibits p110δ with an IC₅₀ of 3.5 nM. Zandelisib functions as an antineoplastic .

HY-138943

5-Fluorouridine 5'-O-β-D-galactopyranoside 5'-O-β-D-galactosyl-5-fluorouridine	Others	Cancer
5-Fluorouridine 5'-O-β-D-galactopyranoside (5'-O-β-D-galactosyl-5-fluorouridine) is a 5-Fluorouridine proagent. 5-Fluorouridine 5'-O-β-D-galactopyranoside can be converted by the enzyme β-D-galactosidase to the potent antineoplastic agent 5-Fluorouridine .

HY-113642

CP-67804	Topoisomerase	Cancer
CP-67804 is a quinolone derivative, is a topoisomerase II-targeted agent. CP-67804 effectively enhances DNA cleavage mediated by eukaryotic topoisomerase II. CP-67804 has potential as an antineoplastic agent .

HY-N5011

5,7-Dimethoxyflavone	Cytochrome P450	Metabolic Disease Inflammation/Immunology Cancer
5,7-Dimethoxyflavone is one of the major components of Kaempferia parviflora, has anti-obesity, anti-inflammatory, and antineoplastic effects. 5,7-Dimethoxyflavone inhibits cytochrome P450 (CYP) 3As. 5,7-Dimethoxyflavone is also a potent Breast Cancer Resistance Protein (BCRP) inhibitor .

Cat. No.	Product Name	Target	Research Area

HY-P0058B

Pramlintide acetate	Amylin Receptor	Metabolic Disease Cancer
Pramlintide acetate is a polypeptide analogue of human amylin. Pramlintide acetate, an antidiabetic agent, is antineoplastic in colorectal cancer .

HY-P0058

Pramlintide	Amylin Receptor	Metabolic Disease Cancer
Pramlintide is a polypeptide analogue of human amylin. Pramlintide, an antidiabetic agent, is antineoplastic in colorectal cancer .

HY-P0058A

Pramlintide TFA	Amylin Receptor	Metabolic Disease Cancer
Pramlintide TFA is a polypeptide analogue of human amylin. Pramlintide TFA, an antidiabetic agent, is antineoplastic in colorectal cancer .

HY-115379

Latromotide	Peptides	Cancer
Latromotide is a synthetic peptide with *antineoplastic* activity. It consists of 10 amino acids corresponding to amino acid residues 66-75 of the human kinesin-like protein KIF20A. Latromotide has a sequence of H-Lys-Val-Tyr-Leu-Arg-Val-Arg-Pro Leu-Leu-OH .

HY-P3315

Onilcamotide RV001	Peptides	Inflammation/Immunology Cancer
Onilcamotide (RV001) is a C-terminal peptide of RhoC protein. Onilcamotide is a cancer vaccine and has potential immunomodulating and antineoplastic activities .

HY-106374

Elpamotide	Peptides	Cancer
Elpamotide is an epitope peptide derived from VEGFR2. Elpamotide induces cytotoxic T lymphocytes (CTLs) to kill VEGFR2-expressing endothelial cells. Elpamotide has potential immunostimulatory and antineoplastic activities. Elpamotide can be used in the research of cancer, such as pancreatic cancer .

HY-P5539

Omramotide

Peptides Cancer

Omramotide is an immunological agent for active immunization (antineoplastic) .
HY-P5540

Oximbomotide

Peptides Cancer

Oximbomotide is an immunological agent for active immunization (antineoplastic) .
HY-P5541

Sucantomotide

Peptides Cancer

Sucantomotide is an immunological agent for active immunization (antineoplastic) .
HY-P4148

Vorumotide

Peptides Inflammation/Immunology Cancer

Vorumotide is an immunological agent for active immunization as well as an antineoplastic agent .
HY-P4151

Marlumotide

Peptides Inflammation/Immunology Cancer

Marlumotide is an immunological agent for active immunization, as well as an antineoplastic agent .
HY-P4152

Etimumotide

Peptides Inflammation/Immunology Cancer

Etimumotide is an immunological agent for active immunization, as well as an antineoplastic agent .
HY-P5534

Enavermotide

UCP2
Peptides Cancer

Enavermotide (UCP2) is an immunological agent for active immunization (antineoplastic) .

HY-P1959A

Lanreotide acetate BIM 23014 acetate	Peptides	Endocrinology Cancer
Lanreotide (BIM 23014) acetate is a somatostatin analogue with antineoplastic activity. Lanreotide acetate can be used for the research of carcinoid syndrome .

HY-P1959

Lanreotide BIM 23014	Peptides	Endocrinology Cancer
Lanreotide (BIM 23014) is a somatostatin analogue with antineoplastic activity. Lanreotide can be used for the research of carcinoid syndrome .

HY-P1959B

Lanreotide diTFA BIM 23014 diTFA	Peptides	Endocrinology Cancer
Lanreotide (BIM 23014) diTFA is a somatostatin analogue with antineoplastic activity. Lanreotide diTFA can be used for the research of carcinoid syndrome .

HY-P4149

Imsamotide IDO194-214	Indoleamine 2,3-Dioxygenase (IDO)	Inflammation/Immunology Cancer
Imsamotide (IDO194-214) is a Indoleamine 2,3-Dioxygenase (IDO) peptide with sequences of DTLLKALLEIASCLEKALQVF, the IDO194-214. Imsamotide is also an immunological agent for active immunization, as well as an antineoplastic agent .

HY-P4145

Quazomotide	Peptides	Inflammation/Immunology Cancer
Quazomotide is a WT1 class II peptide epitope with sequences of RSDELVRHHNMHQRNMTKL. Quazomotide stimulates a peptide-specific CD4(+) response, to recognize WT1(+) tumor cells. Quazomotide is an immunological agent for active immunization, as well as an antineoplastic agent .

HY-P4144

Onvitrelin ucalontide Phor18-LHRH (338613)	GnRH Receptor	Endocrinology Cancer
Onvitrelin ucalontide ([Phor18-LHRH (338613)]) is an analogue of luteinizing hormone releasing hormone (LHRH) with antineoplastic activity. Onvitrelin ucalontide is a peptide with sequences of KFAKFAKKFAKFAKKFAKQHWSYGLRPG. Onvitrelin ucalontide effectively inhibits breast cancer, ovarian cancer and prostate cancer xenografts in mouse model .

Cat. No.	Product Name	Target	Research Area

HY-P990028

Raludotatug

Inhibitory Antibodies Cancer

Raludotatug is a humanized immunoglobulin G1-kappa, anti-CDH6 monoclonal antibody. Raludotatug is an antineoplastic .
HY-P990039

Falbikitug

Inhibitory Antibodies Cancer

Falbikitug is a humanized immunoglobulin G1-kappa, anti-LIF monoclonal antibody. Falbikitug is an antineoplastic .

HY-P990074

Enlonstobart	Inhibitory Antibodies	Inflammation/Immunology
Enlonstobart is a human immunoglobulin G4-kappa, *anti-PDCD1* monoclonal antibody. Enlonstobart is an immunostimulant and antineoplastic .

HY-P990048

Muzastotug

CTLA-4 Cancer

Muzastotug is a humanized immunoglobulin G1-kappa, anti-CTLA4 monoclonal antibody. Muzastotug is an immunostimulant and antineoplastic .
HY-P990095

Vonsetamig

CD3 TNF Receptor Cancer

Vonsetamig is a humanised immunoglobulin G4-kappa, anti-TNFRSF17 and CD3E monoclonal antibody. Vonsetamig is an antineoplastic .
HY-P99628

Futuximab

EGFR Cancer

Futuximab is a chimeric monoclonal antibody targeting non-overlapping epitopes on EGFR. Futuximab has antineoplastic activity .

HY-P990068

Perenostobart	Inhibitory Antibodies	Cancer
Perenostobart is a human immunoglobulin G4-kappa, *anti-ENTPD1/CD39* monoclonal antibody. Perenostobart is an immunostimulant and antineoplastic .

HY-P990073

Davutamig REGN-5093	c-Met/HGFR	Cancer
Davutamig (REGN-5093) is a human immunoglobulin G4-kappa, *anti-MET* monoclonal antibody targeting two different nonoverlapping epitopes on MET. Davutamig is an antineoplastic .

HY-P990092

Rolistobart	Inhibitory Antibodies	Cancer
Rolistobart is a humanized immunoglobulin G4-kappa, *anti-LILRB4/CD85k* monoclonal antibody. Rolistobart is an immunostimulant and antineoplastic .

HY-P990080

Sovipostobart	CTLA-4	Cancer
Sovipostobart is an immunoglobulin G1-kappa, *anti-CTLA-4* human monoclonal antibody with cleavable prodomain. Sovipostobart is an immunostimulant and antineoplastic .

HY-P99498

Cergutuzumab amunaleukin CEA-IL2v; RG 7813; RO 6895882	Interleukin Related	Inflammation/Immunology Cancer
Cergutuzumab amunaleukin (CEA-IL2v) is a monomeric carcinoembryonic antigen (CEA)-targeted IL-2 variant-based immunocytokine. Cergutuzumab amunaleukin has immunostimulating and antineoplastic activities .

HY-P99581

Tabituximab barzuxetan (exclude Y90) OTSA101-DTPA; OTSA101-DTPA-90Y; OTSA101-SS01	Wnt	Cancer
Tabituximab barzuxetan (exclude Y90) is a radioimmunoconjugate composed of a humanized monoclonal antibody targeting FZD-10 (OTSA-101). Tabituximab barzuxetan shows antineoplastic activity. Tabituximab barzuxetan can be used for synovial sarcoma research .

HY-P99658

Imaprelimab PRX-003	Inhibitory Antibodies	Cancer
Imaprelimab (PRX-003) is a humanized IgG1κ anti-melanoma cell adhesion molecule (MCAM) monoclonal antibody. Imaprelimab is an antineoplastic agent .

HY-P99494

Carotuximab TRC105; DE-122	TGF-beta/Smad	Cancer
Carotuximab (TRC105) is a IgG1 monoclonal antibody that blocks endoglin (CD105) and its downstream Smad signaling pathway. Carotuximab has immunomodulatory and antineoplastic actions .

HY-P990032

Belrestotug EOS-448; EOS884448; GSK4428859A	Inhibitory Antibodies	Cancer
Belrestotug (EOS-448) is an antagonistic anti-TIGIT (VSIG9, VSTM3) human immunoglobulin G1 kappa (hIgG1 kappa) antibody. Belrestotug shows antineoplastic activity .

HY-P990072

Lipustobart	PD-1/PD-L1	Cancer
Lipustobart is an IgG4-kappa, anti-PDCD1 (programmed cell death 1, PD1, PD-1, CD279) humanized monoclonal antibody. Lipustobart shows immunostimulant and antineoplastic activity .

HY-P990014

Danburstotug IMC-001; STI-3031	PD-1/PD-L1	Inflammation/Immunology Cancer
Danburstotug (IMC-001) is an IgG1-lambda anti-CD274 (PDL1, B7 homologue 1, B7H1) human monoclonal antibody. Danburstotug also is immunostimulant and antineoplastic .

HY-P990037

Erzotabart	CD38	Cancer
Erzotabart is an IgG1-kappa, anti-CD38 (ADP-ribosyl cyclase 1, cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, cADPR1) Homo sapiens monoclonal antibody. Erzotabart shows antineoplastic activity .

HY-P990086

Vopikitug	Interleukin Related	Cancer
Vopikitug is an IgG1-kappa, anti-IL2RA (interleukin 2 receptor alpha subunit, IL-2RA, TAC, p55, CD25) homo sapiens monoclonal antibody. Vopikitug shows antineoplastic activity .

HY-P99386

Vesencumab MNRP-1685A	Complement System	Cancer
Vesencumab (MNRP-1685A) is IG1 antibody against neuropilin-1 (NRP-1). Vesencumab binds to NRP-1 and prevents the subsequent coupling of NRP-1 to VEGFR-2. Vesencumab has anti-angiogenic and anti-neoplastic activities. Vesencumab can be used in the research of metastatic solid tumors, including ovarian cancer .

HY-P99328

Tucotuzumab Anti-EPCAM Recombinant Antibody; huKS-IL2	Interleukin Related	Inflammation/Immunology Cancer
Tucotuzumab (Anti-EPCAM Recombinant Antibody) is an antigen-specific IgG1 monoclonal antibody that targets human epithelial cell adhesion molecule (EpCAM). Tucotuzumab links two IL-2 molecules and is an immunosuppressant and anti-tumor active molecule .

HY-P99011

Cibisatamab	CD3	Cancer
Cibisatamab (CEA-TCB), a T cell bispecific antibody, binds Carcino-Embryonic Antigen (CEA) on cancer cells and CD3 on T cells. Cibisatamab (CEA-TCB) triggers T cell killing of cancer cell lines expressing moderate to high levels of CEA at the cell surface. Cibisatamab (CEA-TCB) can be used for colorectal cancer research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13667

Levoleucovorin Calcium 2 Publications Verification Calcium levofolinate; CL307782	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Antifolate
Levoleucovorin Calcium (Calcium levofolinate), a levo isoform of Leucovorin Calcium (HY-13664), possesses antineoplastic effects. Levoleucovorin Calcium is also an augmentor of 5-fluorouracil (HY-90006) cytotoxicity against cancer .

HY-N9271

Grifolin	Structural Classification Microorganisms Source classification Phenols Polyphenols	Apoptosis
Grifolin is an antineoplastic agent can be isolated from the mushroom Albatrellus confluens and significantly induces apoptosis .

HY-121401

Myrtenal (±)-Myrtenal	Structural Classification Other Monoterpenes Terpenoids Labiatae Source classification Erythrina poeppigiana Plants	Others
Myrtenal ((±)-Myrtenal) is a monoterpene that acts as an antineoplastic agent. Myrtenal inhibits liver cancer by preventing DEN-PB-induced upregulation of TNF-α protein expression.

HY-116280

Aceratioside	Structural Classification Monophenols Elaeocarpaceae Source classification Phenols Plants Aceratium megalospermum (F.Muell.) Balgooy Saccharides Monosaccharides	Others
Aceratioside, a tetralin glucoside, is a weakly cytostatic constituent. Aceratioside is an antineoplastic agent .

HY-134008

Protoapigenone	Structural Classification Flavonoids Flavones Source classification Plants Macrothelypteris torresiana (Gaud.) Ching Thelypteridaceae	Others
Protoapigenone is an antineoplastic agent isolated from ferns. Protoapigenone has significant inhibitory activity against Hep G2, Hep 3B, MCF-7, A549 and MDAMB-231, with IC₅₀s values of 1.60, 0.23, 0.78, 3.88 and 0.27 μg/mL respectively .

HY-N2812

Epipodophyllotoxin acetate 4-O-Epipodophyllotoxinyl acetate	Structural Classification Cupressaceae Source classification Lignans Phenylpropanoids Plants	HSV VSV
Epipodophyllotoxin acetate (4-O-Epipodophyllotoxinyl acetate; compound 4) is a cyclolignan that exhibits antineoplastic and antiviral activities. Epipodophyllotoxin acetate inhibits HSV and VSV, with IC₅₀s of 0.2 and 0.1 μg/mL, respectively .

HY-N11110

Inuviscolide	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae Erythrina arborescens Roxb.	Apoptosis
Inuviscolide is an apoptosis inducer. Inuviscolide can induce of G₂/M arrest in human melanoma cell lines. Inuviscolide exhibits antineoplastic and anti-inflammatory activities .

HY-N10470

Bleomycin A5 1 Publications Verification Pingyangmycin	Structural Classification Natural Products Microorganisms Animals Source classification	Apoptosis
Bleomycin A5 (Pingyangmycin) is an orally active glycopeptide antibiotics. Bleomycin A5 has a role as an antineoplastic agent, an apoptosis inducer and a bacterial metabolite .

HY-N12262

(+)-Epieudesmin	Structural Classification other families Hernandia nymphaeifolia (C. Presl) Kubitzki Source classification Lignans Phenylpropanoids Plants	Bacterial
(+)-Epieudesmin is an antineoplastic agent. (+)-Epieudesmin has marginal cancer cell line inhibitory activities. (+)-Epieudesmin inhibits the growth of Gram-negative pathogen .

HY-N10591

Bruceantarin	Structural Classification Natural Products Simaroubaceae Plants Brucea javanica (L.) Merr.	Others
Bruceantarin is a potent *antineoplastic* agent. Bruceantarin can be used for leukemia and breast cancer research .

HY-N5011

5,7-Dimethoxyflavone	Structural Classification Flavonoids Classification of Application Fields Flavones Kaempferia parviflora Wall. ex Baker Plants Inflammation/Immunology Disease Research Fields Cancer Zingiberaceae	Cytochrome P450
5,7-Dimethoxyflavone is one of the major components of Kaempferia parviflora, has anti-obesity, anti-inflammatory, and antineoplastic effects. 5,7-Dimethoxyflavone inhibits cytochrome P450 (CYP) 3As. 5,7-Dimethoxyflavone is also a potent Breast Cancer Resistance Protein (BCRP) inhibitor .

HY-19825

Rebeccamycin	Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields Other Antibiotics Cancer	Topoisomerase ADC Cytotoxin Antibiotic
Rebeccamycin, an antitumor antibiotic, inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I and has negligible effect on protein kinase C and topoisomerase II .

HY-120098

Vinleurosine	Apocynaceae Structural Classification Alkaloids Source classification Plants Catharanthus roseus (L.) G. Don	Others
Vinleurosine is an indole alkaloid with antineoplastic activity .

HY-13768A

Topotecan hydrochloride 15+ Cited Publications SKF 104864A hydrochloride; NSC 609669 hydrochloride	Alkaloids Structural Classification Monophenols Classification of Application Fields Source classification Phenols Quinoline Alkaloids Camptotheca acuminata Decne. Plants Nyssaceae Disease Research Fields Cancer	Topoisomerase Autophagy Apoptosis
Topotecan Hydrochloride (SKF 104864A Hydrochloride) is a Topoisomerase I inhibitor with potent antineoplastic activities.

HY-N6031

Dendrophenol Moscatilin	Structural Classification Classification of Application Fields Orchidaceae Source classification Phenols Polyphenols Plants Disease Research Fields Dendrobium chrysanthum Wall. ex Lindl. Cancer	NF-κB
Dendrophenol (Moscatilin) acts as a NF-κB inhibitor . Antineoplastic activity .

HY-15753

Ellipticine 3 Publications Verification NSC 71795	Apocynaceae Alkaloids Classification of Application Fields Source classification Plants Amsonia elliptica (Thunberg ex Murray) Roemer & Schultes Disease Research Fields Indole Alkaloids Cancer	Topoisomerase
Ellipticine (NSC 71795) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.

HY-15753A

Ellipticine hydrochloride 3 Publications Verification NSC 71795 hydrochloride	Apocynaceae Alkaloids Structural Classification Classification of Application Fields Source classification Plants Amsonia elliptica (Thunberg ex Murray) Roemer & Schultes Disease Research Fields Indole Alkaloids Cancer	Topoisomerase
Ellipticine (NSC 71795) hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.

HY-15459

Cabazitaxel 15+ Cited Publications XRP6258; RPR-116258A; taxoid XRP6258	Structural Classification Natural Products Classification of Application Fields Source classification Taxaceae Plants Disease Research Fields Cancer Taxus chinensis (Pilger) Rehd.	Microtubule/Tubulin Autophagy
Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity.

HY-N0679

Retinyl acetate 2 Publications Verification Retinol acetate; Vitamin A acetate	Terpenoids Source classification Diterpenoids Endogenous metabolite Disease Research Fields Cancer	Others
Retinyl acetate is a synthetic acetate ester form derived from retinol and has potential antineoplastic and chemo preventive activities .

HY-N8676

Antiproliferative agent-29	Triterpenes Structural Classification Terpenoids Zygophyllaceae Source classification Peganum harmala Linn. Plants	Others
Antiproliferative agent-29 (Compound 16) is a triterpenoid isolated from the seeds of Peganum harmala L. Antiproliferative agent-29 has antiproliferative activity and has potential for cancer research .

HY-N8677

Antiproliferative agent-28	Triterpenes Structural Classification Terpenoids Zygophyllaceae Source classification Peganum harmala Linn. Plants	Others
Antiproliferative agent-28 (Compound 14) is a triterpenoid isolated from the seeds of Peganum harmala L. Antiproliferative agent-28 has antiproliferative activity and has potential for cancer research .

HY-18258

Berberine chloride 30+ Cited Publications Natural Yellow 18 chloride	Alkaloids Structural Classification Phellodendron amurense Rupr. Classification of Application Fields Source classification Rutaceae Plants Isoquinoline Alkaloids Disease Research Fields Biological Pesticide Research Cancer Agricultural Research	Topoisomerase Autophagy Bacterial Reactive Oxygen Species Antibiotic Endogenous Metabolite Parasite
Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties .

HY-N7651

Neoanhydropodophyllol	Classification of Application Fields Source classification Lignans Dysosma versipellis (Hance) M. Cheng ex Ying Phenylpropanoids Plants Berberidaceae Disease Research Fields Cancer	Others
Neoanhydropodophyllol is a cyclolignan derivative, with antineoplastic activity. Neoanhydropodophyllol displays cytotoxicity against several cancer cells (leukemia, lung carcinoma and colon carcinoma) .

HY-17577

Berberine chloride hydrate 30+ Cited Publications Natural Yellow 18 chloride hydrate	Alkaloids Structural Classification Classification of Application Fields Source classification Ranunculaceae Coptis chinensis Franch. Plants Isoquinoline Alkaloids Disease Research Fields Cancer	Topoisomerase Autophagy Bacterial Reactive Oxygen Species Antibiotic Endogenous Metabolite Parasite
Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid that acts as an antibiotic. Berberine chloride hydrate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties .

HY-B0015

Paclitaxel Maximum Cited Publications 180 Publications Verification	Structural Classification Classification of Application Fields Terpenoids Taxaceae Diterpenoids Plants Disease Research Fields Cancer Taxus chinensis (Pilger) Rehd.	Microtubule/Tubulin ADC Cytotoxin Apoptosis Autophagy
Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy .

HY-N3154

Odorinol	Structural Classification Natural Products Source classification Aglaia odorata Lour. Plants Meliaceae	Others
Odorinol is a natural product isolated from branches and leaves of Aglaia odorata. Odorinol has potential antineoplastic activity and can inhibit both the initiation and promotion stages of skin cancer .

HY-N6038

Gartanin	other families Xanthones Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Fungal Autophagy
Gartanin is a natural xanthone of mangosteen, with antioxidant, anti-inflammatory, antifungal, neuroprotective and antineoplastic properties. Gartanin induces cell cycle arrest and autophagy and suppresses migration in human glioma cells .

HY-121199

Germanicol	Triterpenes Structural Classification Euphorbia boetica Terpenoids Source classification Euphorbiaceae Plants	Apoptosis
Germanicol is a selective antineoplastic agent against human colon cancer cell lines HCT-116 and HT29 . Germanicol induces apoptosis via chromatin condensation and DNA damage .

HY-N3155

Odorine Roxburghiline	Triterpenes Structural Classification Terpenoids Source classification Aglaia odorata Lour. Plants Meliaceae	Others
Odorine (Roxburghiline) is a natural product isolated from branches and leaves of Aglaia odorata. Odorine has potential antineoplastic activity and can inhibit both the initiation and promotion stages of skin cancer .

HY-N0876

Arenobufagin 3 Publications Verification	Structural Classification Classification of Application Fields Animals Source classification Disease Research Fields Steroids Cancer	Others
Arenobufagin is a natural bufadienolide from toad venom; has potent antineoplastic activity against HCC HepG2 cells as well as corresponding multidrug-resistant HepG2/ADM cells.

HY-B1468

8-Azaguanine 2 Publications Verification	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Nucleoside Antimetabolite/Analog Endogenous Metabolite
8-Azaguanine is a purine analogue that shows antineoplastic activity. 8-Azaguanine functions as an antimetabolite and easily incorporates into ribonucleic acids, interfering with normal biosynthetic pathways, thus inhibiting cellular growth .

HY-N3883

Euxanthone	Structural Classification Flavonoids Garcinia oblongifolia Champ. ex Benth. Source classification Guttiferae Plants Other Flavonoids	Autophagy
Euxanthone, a xanthone derivative, attenuates Aβ1-42-induced oxidative stress and apoptosis by triggering autophagy. Euxanthone exhibits anti-neoplastic and neuroprotective activities .

HY-N11912

Soladulcoside A	Structural Classification Source classification Solanum nigrum Linn. Plants Solanaceae Steroids	Biochemical Assay Reagents
Soladulcoside A is a steroidal glycoside and antineoplastic agent that can be obtained from the whole plant of Solanum nigrum. Soladulcoside A can inhibit A549 cells and has the potential to study cancers such as non-small cell lung cancer (NSCLC) .

HY-114335

Triphala	Infection Structural Classification Natural Products Classification of Application Fields Combretaceae Source classification Terminalia chebula Retz. Plants Inflammation/Immunology Disease Research Fields	NF-κB Fungal
Triphala, an Ayurvedic polyherbal formulation comprising of equiproportional fruit parts of Terminalia chebula, Terminalia bellerica, and Phyllanthus emblica . Triphala inhibits NF-κB activation. Triphala exerts antifungal action . Anti-adipogenic, anti-inflammatory, and anti-neoplastic activities.

HY-N0716B

Berberine sulfate 30+ Cited Publications Natural Yellow 18 sulfate	Alkaloids Structural Classification Classification of Application Fields Source classification Ranunculaceae Coptis chinensis Franch. Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields	Topoisomerase Autophagy Bacterial Reactive Oxygen Species Parasite
Berberine sulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine sulfate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine sulfate has antineoplastic properties. The sulfate form improves bioavailability .

HY-N3913

Furowanin A	Structural Classification Flavonoids Leguminosae Source classification Plants Derris taiwaniana (Hayata) Z. Q. Song Isoflavones	STAT Bcl-2 Family
Furowanin A is a flavonoid with anti-neoplastic effects. Furowanin A inhibits STAT3/Mcl-1 axis to suppress proliferation, block cell cycle progression, induce apoptosis and promote autophagy. Furowanin A potently inhibits colorectal cancer (CRC) cells .

HY-N0716

Berberine Natural Yellow 18	Structural Classification Classification of Application Fields Anti-aging Source classification Ranunculaceae Plants Endogenous metabolite Biological Pesticide Research Agricultural Research Alkaloids Coptis chinensis Franch. Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Cancer	Topoisomerase Autophagy Bacterial Reactive Oxygen Species Endogenous Metabolite Antibiotic Parasite
Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine (Natural Yellow 18) induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine (Natural Yellow 18) has antineoplastic properties. The sulfate form (HY-N0716B) improves bioavailability .

HY-16560

Camptothecin 35+ Cited Publications Campathecin; (S)-(+)-Camptothecin; CPT	Infection Alkaloids Structural Classification Classification of Application Fields Source classification Quinoline Alkaloids Camptotheca acuminata Decne. Plants Nyssaceae Disease Research Fields	Topoisomerase ADC Cytotoxin MicroRNA Influenza Virus Apoptosis Fungal Antibiotic
Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC₅₀ of 679 nM . Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells .

HY-N6621

Hippeastrine	Alkaloids Pyrrole Alkaloids Classification of Application Fields Narcissus tazetta Linn. var. chinensis M.Roemer Source classification Plants Disease Research Fields Amaryllidaceae Cancer	Topoisomerase
Hippeastrine, an active alkaloid, exhibits a good dose-dependent inhibitory effect against topoisomerase I (Top I) with an IC₅₀ at 7.25 μg/mL. Antiproliferative and anticancer activities .

HY-12033

2-Methoxyestradiol 20+ Cited Publications 2-ME2; NSC-659853	Structural Classification Monophenols Classification of Application Fields Source classification Disease markers Phenols Endocrine diseases Endogenous metabolite Disease Research Fields Steroids Cancer	Microtubule/Tubulin Reactive Oxygen Species Apoptosis Autophagy Endogenous Metabolite
2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa .

Cat. No.	Product Name	Chemical Structure

HY-B0245S

Busulfan-d8
Busulfan-d₈ is a deuterium labeled Busulfan. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent[1][2][3].

HY-B0015S

Paclitaxel-d5

Paclitaxel-d₅ is a deuterium-labeled Paclitaxel. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization[1].
HY-12289S

Defactinib-d6

Defactinib-d6 is a deuterium labeled Defactinib (HY-12289). Defactinib is a novel FAK inhibitor with potential antiangiogenic and antineoplastic activities .
HY-152852S

Mefatinib-d6 free base

Mefatinib-d6 free base (Mifanertinib-d6) is the deuterium labeled Mefatinib. Mefatinib is a potent tyrosine kinase inhibitor with antineoplastic activity .
HY-B0078S

Dacarbazine-d6

Dacarbazine-d₆ is the deuterium labeled Dacarbazine. Dacarbazine(DTIC-Dome; DTIC) is an antineoplastic agent. It has significant activity against melanomas.

HY-17420S1

Cyclophosphamide-d8
Cyclophosphamide-d₈ is deuterium labeled Cyclophosphamide. Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant.

HY-132549S

Nilotinib-d3

Nilotinib-d₃ is the deuterium labeled Nilotinib. Nilotinib is an orally available Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity[1][2].

HY-15459S1

Cabazitaxel-d9
Cabazitaxel-d₉ is deuterium labeled Cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity.

HY-17420S

Cyclophosphamide-d4
Cyclophosphamide-d₄ is the deuterium labeled Cyclophosphamide. Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant[1][2].

HY-17420AS

Cyclophosphamide-d8 hydrate
Cyclophosphamide-d₈ (hydrate) is the deuterium labeled Cyclophosphamide hydrate. Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities[1][2].

HY-15459S

Cabazitaxel-d6
Cabazitaxel-d₆ is the deuterium labeled Cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity[1][2].

HY-18258S

Berberine-d6 chloride
Berberine-d₆ (chloride) is the deuterium labeled Berberine chloride. Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties[1].

HY-N0679S4

Retinyl acetate-d4
Retinyl acetate-d₄ is the deuterium labeled Retinyl acetate[1]. Retinyl acetate is a synthetic acetate ester form derived from retinol and has potential antineoplastic and chemo preventive activities[2].

HY-16271S

Kevetrin hydrochloride-13C2,15N3
Kevetrin (hydrochloride)- ¹³C₂, ¹⁵N₃ is the ¹³C-labeled and ¹⁵N-labeled Kevetrin (hydrochloride). Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.

HY-B0015S1

Paclitaxel-d5 (benzoyloxy)
Paclitaxel-d₅ (benzoyloxy) is the deuterium labeled Paclitaxel. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy[1][2].

HY-B0003S

Gemcitabine-13C,15N2 hydrochloride
Gemcitabine- ¹³C, ¹⁵N₂ (hydrochloride) is the ¹³C and ¹⁵N labeled Gemcitabine hydrochloride[1]. Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis[2][3].

HY-13593S

Chlorambucil-d8
Chlorambucil-d₈ is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease[1][2][3][4].

HY-13593S1

Chlorambucil-d8-1
Chlorambucil-d₈-1 is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease[1][2][3][4].

HY-B0497S1

Niclosamide-13C6
Niclosamide- ¹³C₆ is the ¹³C₆ labeled Niclosamide. Niclosamide (BAY2353) is an orally bioavailable chlorinated salicylanilide, with anthelmintic and potential antineoplastic activity. Niclosamide (BAY2353) inhibits STAT3 with IC50 of 0.25 μM in HeLa cells and inhibits DNA replication in a cell-free assay.

HY-14519S1

Methotrexate-d3 diammonium

Methotrexate-d₃ diammonium is the deuterium labeled Methotrexate diammonium. Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .

HY-14519S

Methotrexate-d3

Methotrexate-d₃ (Amethopterin-d3) is the deuterium labeled Methotrexate. Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia)[1][2][3].

HY-16560S

Camptothecin-d5

Camptothecin-d₅ is the deuterium labeled Camptothecin. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM[1]. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells[2][3].

HY-B0011AS

Docetaxel-d5 trihydrate

Docetaxel-d₅ (trihydrate) is the deuterium labeled Docetaxel (Trihydrate). Docetaxel Trihydrate (RP-56976 Trihydrate) is an antineoplastic agent and inhibits microtubule depolymerization with an IC50 value of 0.2 μM[1]. Docetaxel Trihydrate is a semisynthetic analog of taxol and attenuates the effects of bcl-2 and bcl-xL gene expression. Docetaxel Trihydrate arrests the cell cycle at G2/M and leads to cell apoptosis[1][3].

HY-10224S

Panobinostat-d4

Panobinostat-d₄ is the deuterium labeled Panobinostat. Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities[1][2]. Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1 expression in latently infected cells[4]. Panobinostat induces cell apoptosis and autophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma[3].

HY-10224S1

Panobinostat-d4 hydrochloride

Panobinostat-d₄ (hydrochloride) is deuterium labeled Panobinostat. Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities[1][2]. Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1 expression in latently infected cells[4]. Panobinostat induces cell apoptosis and autophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma[3].

HY-12033S2

2-Methoxyestradiol-d5

2-Methoxyestradiol-d₅ is the deuterium labeled 2-Hydroxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[1][2][3][4][5][6][7].

HY-13690S1

Mitotane-13C6

Mitotane- ¹³C₆ is the ¹³C labeled Mitotane[1]. Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions[2][3][4][5].

HY-13690S2

Mitotane-d8

Mitotane-d₈ is the deuterium labeled Mitotane[1]. Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions[2][3][4][5].

HY-12033S

2-Methoxyestradiol-13C,d3

2-Methoxyestradiol- ¹³C,d₃ is the ¹³C- and deuterium labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[1][2][3][4][5][6].

HY-12033S1

2-Methoxyestradiol-13C6

2-Methoxyestradiol- ¹³C₆ is the ¹³C-labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[1][2][3][4][5][6].

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