Search Result

Results for "

Antitrypanosomal

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (2) Apoptosis (4) Bacterial (2) COX (1) Cytochrome P450 (1) Fungal (2) GSK-3 (1) Parasite (35) Phosphatase (2) Proteasome (1) Reverse Transcriptase (2) SARS-CoV (2) Sirtuin (2) Topoisomerase (2)
By Research Areas:	Cancer (4) Cardiovascular Disease (2) Infection (34) Inflammation/Immunology (4)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-151943

Antitrypanosomal agent 11

Parasite Infection

Antitrypanosomal agent 11 is an antitrypanosomal agent that inhibits Trypanosoma cruzi with an IC₅₀ of 0.23 μM .
HY-151942

Antitrypanosomal agent 10

Parasite Infection

Antitrypanosomal agent 10 is an antitrypanosomal agent that inhibits Trypanosoma cruzi with an IC₅₀ of 0.28 μM .

Antitrypanosomal agent 11	Parasite	Infection
Antitrypanosomal agent 11 is an antitrypanosomal agent that inhibits Trypanosoma cruzi with an IC₅₀ of 0.23 μM .

Antitrypanosomal agent 10	Parasite	Infection
Antitrypanosomal agent 10 is an antitrypanosomal agent that inhibits Trypanosoma cruzi with an IC₅₀ of 0.28 μM .

HY-149985

Antitrypanosomal agent 12	Parasite	Infection
Antitrypanosomal agent 12 is a C20-phenylthiourea with trypanocidal and cytotoxic activities. Antitrypanosomal agent 12 shows antitrypanosomal activity with 50% growth inhibition (GI₅₀) values of 0.22 μM. Antitrypanosomal agent 12 induces faster cell swelling in bloodstream-form trypanosomes than Salinomycin (HY-15597) .

HY-149986

Antitrypanosomal agent 13	Parasite	Infection
Antitrypanosomal agent 13 (compound 4b) is a potent antitrypanosomal agent. Antitrypanosomal agent 13 has trypanocidal and cytotoxic activity with GI₅₀ values of 0.18 and 8.4 μM for T. brucei and HL-60, respectively .

HY-146049

Antitrypanosomal agent 4	Parasite	Infection
Antitrypanosomal agent 4 (compound 19) is a potent and blood-brain barrier permeable antitrypanosomal agent. Antitrypanosomal agent 4 has good activity against Trypanosoma cruzi (T. cruzi) and Trypanosoma brucei brucei (T. b. brucei) with IC₅₀s of 1.2 μM and 70 nM, respectively . Antitrypanosomal agent 4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-147550

Antitrypanosomal agent 7	Parasite	Infection
Antitrypanosomal agent 7 (compound 18c) is a potent and antitrypanosomal agent with favorable ADME properties. Antitrypanosomal agent 7 is > 2-fold more potent against Trypanosoma brucei (T. brucei) than Nifurtimox, with an IC₅₀ value of 0.71 μM. Antitrypanosomal agent 7 has strong interaction to DNA and can bind with high selectivity to AT-rich DNA .

HY-147549

Antitrypanosomal agent 6	Parasite	Infection
Antitrypanosomal agent 6 (compound 18a) is a potent and antitrypanosomal agent with favorable ADME properties. Antitrypanosomal agent 6 is > 2-fold more potent against Trypanosoma brucei (T. brucei) than Nifurtimox, with an IC₅₀ value of 0.47 μM. Antitrypanosomal agent 6 has strong interaction to DNA and can bind with high selectivity to AT-rich DNA .

HY-147933

Antitrypanosomal agent 8	Parasite	Infection
Antitrypanosomal agent 8 (compound 3b) has potent antitrypanosomal activity against Trypanosoma brucei with an IC₅₀ value of 0.79 μM and exhibits certain cytotoxicity in L6 cells (IC₅₀=80.95 μM) .

HY-163003

Antitrypanosomal agent 19	Parasite	Infection
Antitrypanosomal agent 19 (compound 10) is an orally available antitrypanosomal agent. Antitrypanosomal agent 19 effectively inhibits the growth of trypanosomatids T. b. brucei, T. b. gambiense and T. b. rhodesiense, mitigating the Human trypanosomiasis (HAT)-induced acute infectious toxicity in mice .

HY-Q40175

Antitrypanosomal agent 9	Parasite	Infection
Antitrypanosomal agent 9 (compound 1) is a potent antitrypanosomal agent. Antitrypanosomal agent 9 shows inhibitory activity against T. b. brucei, with an IC₅₀ of 1.15 μM. Antitrypanosomal agent 9 can be used for human African trypanosomiasis (HAT) research .

HY-155401

Antitrypanosomal agent 18	Parasite	Others
Antitrypanosomal agent 18 (compound 8b) is a nitrofuran derivative has strong trypanocidal activity in vitro with an IC₅₀ value of 0.03 μM .

HY-W052512

Antitrypanosomal agent 1	Parasite	Infection
Antitrypanosomal agent 1 is a potent and selective trypanothione reductase (TR) inhibitor with an IC₅₀ of 3.3 μM. Antitrypanosomal agent 1 inhibits glutathione reductase (GR) (IC₅₀=64.8 μM) and T. brucei (EC₅₀=1 μM). Antitrypanosomal agent 1 has anti-trypanosomal activity .

HY-161237

Antitrypanosomal agent 20

Parasite Infection

Antitrypanosomal agent 20 (Compd 27) is an anti-trypanosomal, with an IC₅₀ of 0.75 μM for T. b. brucei .

Antitrypanosomal agent 20	Parasite	Infection
Antitrypanosomal agent 20 (Compd 27) is an anti-trypanosomal, with an IC₅₀ of 0.75 μM for T. b. brucei .

HY-155025

Antitrypanosomal agent 14	Parasite GSK-3	Infection
Antitrypanosomal agent 14 (Compound 1) is a T. brucei inhibitor (EC₅₀: 0.47 μM). Antitrypanosomal agent 14 inhibits TbGSK3 with an IC₅₀ of 12 μM. Antitrypanosomal agent 14 can be used for the research of Human African trypanosomiasis .

HY-146071

Antitrypanosomal agent 5	Parasite	Infection
Antitrypanosomal agent 5 (Compound 25)is a selective anti-trypanosomal agent with IC₅₀s of 1 nM and 483.3 µM against T. brucei cell growth and HEK293 cells growth , respectively .

HY-136200

Antitrypanosomal agent 2

Parasite Infection

Antitrypanosomal agent 2 is a potent and selective trypanosoma brucei inhibitor .

Antitrypanosomal agent 2	Parasite	Infection
Antitrypanosomal agent 2 is a potent and selective *trypanosoma* *brucei* inhibitor .

HY-155103

Antitrypanosomal agent 15	Proteasome Parasite	Infection
Antitrypanosomal agent 15 (compound 26) is an orally active, brain-penetrant, selective inhibitor against Trypanosoma cruzi proteasome, with an _pIC₅₀ of 7.4 and <4 for T. cruzi and human proteasome, respectively. Antitrypanosomal agent 15 has favorable ADME properties and can be used for Chagas disease study .

HY-155399

Antitrypanosomal agent 16

Parasite Others

Antitrypanosomal agent 16 is a trypanocide with IC₅₀ of 0.04μM in T. congolense strain IL3000 .
HY-155400

Antitrypanosomal agent 17

Parasite Infection

Antitrypanosomal agent 17 (Compd 7a) possesses antiamastigote activity, with an IC₅₀ of 0.03 μM against T. congolense strain IL3000 .
HY-126571

Virustomycin A

Parasite Infection

Virustomycin A is a nature product that could be isolated from Streptomyces. Virustomycin A has selective and potent antitrypanosomal activity .

Antitrypanosomal agent 16	Parasite	Others
Antitrypanosomal agent 16 is a trypanocide with IC₅₀ of 0.04μM in T. congolense strain IL3000 .

Antitrypanosomal agent 17	Parasite	Infection
Antitrypanosomal agent 17 (Compd 7a) possesses antiamastigote activity, with an IC₅₀ of 0.03 μM against T. congolense strain IL3000 .

Virustomycin A	Parasite	Infection
Virustomycin A is a nature product that could be isolated from Streptomyces. Virustomycin A has selective and potent antitrypanosomal activity .

HY-N6007

Chrysosplenol D	Apoptosis	Infection Inflammation/Immunology Cancer
Chrysosplenol D is a methoxy flavonoid that induces ERK1/2-mediated apoptosis in triple negative human breast cancer cells. Chrysosplenol D also exhibits anti-inflammatory and moderate antitrypanosomal activities .

HY-N12654

Irumamycin	Fungal Parasite Antibiotic	Infection
Irumamycin is a natural 20-membered macrolide antibiotic. Irumamycin is active in vitro against some phytopathogenic fungi . Irumamycin also shows potent antitrypanosomal activity .

HY-N9488

Girinimbine Girinimbin	Apoptosis Bacterial Parasite	Infection Inflammation/Immunology Cancer
Girinimbine (Girinimbin) is a carbazole alkaloid with a variety of biological effects. Girinimbine can induce apoptosis, and has antitrypanosomal, antiplatelet activity, antibacterial activity, anti-inflammatory, antioxidant and antitumor activities .

HY-13801

Fexinidazole HOE 239	Parasite	Infection
Fexinidazole (HOE 239) is an orally active, potent nitroimidazole antitrypanosomal agent. Fexinidazole shows trypanocidal activity against T. brucei subspecies and strains with IC₅₀s of 0.7-3.3 μM (0.2-0.9 μg/ml). Fexinidazol has the potential for human sleeping sickness (HAT) caused by infection with T. brucei .

HY-100496

Nucleocidin 4'-Fluoro-5'-O-sulfamoyladenosine; NSC 521007	Bacterial	Infection
Nucleocidin is an antitrypanosomal antibiotic, inhibiting the transfer of labeled amino acid from S-RNA to protein.

HY-N8257

Dehydrobruceine A

Parasite Infection Inflammation/Immunology

Dehydrobruceine A is a low potent antitrypanosomal agent, with an IC₅₀ of 88.5 nM for Plasmodium falciparum .

Dehydrobruceine A	Parasite	Infection Inflammation/Immunology
Dehydrobruceine A is a low potent antitrypanosomal agent, with an IC₅₀ of 88.5 nM for Plasmodium falciparum .

HY-126417

Methylenetanshinquinone	Parasite	Infection
Methylenetanshinquinone is a natural compound with antiplasmodial, antitrypanosomal and antioxidative activities. Methylenetanshinquinone can be used for the research of parasite infection .

HY-N8476

Sahandol

Parasite Infection

Sahandol is a diterpene, that can be isolated from Salvia sahendica. Sahandol shows antiplasmodial, antitrypanosomal, and cytotoxic activities .

Sahandol	Parasite	Infection
Sahandol is a diterpene, that can be isolated from Salvia sahendica. Sahandol shows antiplasmodial, antitrypanosomal, and cytotoxic activities .

HY-124035

Streptochlorin SF2583A	Antibiotic Parasite	Infection
Streptochlorin (SF2583A) is an antibiotic. Streptochlorin has antitrypanosomal activity with an IC₅₀ value of 230 ng/ml for GUTat 3.1 .

HY-125648

Euphorbadienol alpha-Euphorbol	Parasite	Infection
Euphorbadienol (alpha-Euphorbol), a triterpenic compound, isolated from the latex of Euphorbia resinifera. The derivatives of Euphorbadienol can be used as elicitors of disease resistance, and has antileishmanial and antitrypanosomal activity .

HY-N11550

Salviandulin E	Parasite	Infection
Salviandulin E is a diterpenoid compound that can be isolated from Salvia leucantha CAV.. Salviandulin E shows antitrypanosomal activity against T. b. brucei GUTat 3.1 parasites with an IC₅₀ value of 0.72 µg/mL .

HY-108938

SDZ285428	Cytochrome P450 Fungal Parasite	Infection
SDZ285428 is a CYP51 inhibitor. SDZ285428 inhibits Trypanosoma cruzi (TC) CYP51 with I/E2 <1 (5 min) and I/E2=9 (1 h). SDZ285428 inhibits Trypanosoma brucei (TB) CYP51 with I/E2 <1 (5 min) and I/E2=35 (1 h) .

HY-N2230

N-p-trans-Coumaroyltyramine
N-p-trans-Coumaroyltyramine is a cinnamoylphenethyl amide isolated from polygonum hyrcanicum, acts as an acetylcholinesterase (AChE) inhibitor with an an IC₅₀ of 122 μM. N-p-trans-Coumaroyltyramine exhibits anti-trypanosomal activity with an IC₅₀ of 13.3 µM for T. brucei rhodesiense .

HY-N0389

Columbin 1 Publications Verification	COX Parasite	Inflammation/Immunology
Columbin is an orally active diterpenoid furanolactone from Calumbae radix, has anti-inflammatory and anti-trypanosomal effects. Columbin selectively inhibits COX-2 (EC₅₀=53.1 μM) over COX-1 (EC₅₀=327 μM) .

HY-155732

NPD-2975	Parasite	Infection
NPD-2975 (compound 30) is an orally active antitrypanosomal agent, against Human African Trypanosomiasis (HAT). NPD-2975 has low toxicity potential against human MRC-5 lung fibroblasts, and acute mouse model of T. b. brucei infection. NPD-2975 shows acceptable metabolic stability, inhibits T. b. brucei with IC₅₀0 of 70 nM in vitro. NPD-2975 also inhibits CYP enzymes resulted in IC₅₀ values of 0.16 and 0.42 μM against CYP1A2 and CYP2C19, respectively .

HY-B0879

Suramin	Phosphatase Sirtuin Reverse Transcriptase Topoisomerase SARS-CoV Parasite Apoptosis	Infection Cardiovascular Disease Cancer
Suramin is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor . Suramin is a potent inhibitor of sirtuins: SirT1 (IC₅₀=297 nM), SirT2 (IC₅₀=1.15 μM), and SirT5 (IC₅₀=22 μM) . Suramin is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC₅₀=5 μM) . Suramin is a potent SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor .Suramin efficiently inhibits IP5K and is an antiparasitic, anti-neoplastic and anti-angiogenic agent .

HY-B0879A

Suramin sodium salt Maximum Cited Publications 13 Publications Verification Suramin hexasodium salt	Phosphatase Sirtuin Reverse Transcriptase Topoisomerase SARS-CoV Parasite Apoptosis	Infection Cardiovascular Disease Cancer
Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor . Suramin sodium salt is a potent inhibitor of sirtuins: SirT1 (IC₅₀=297 nM), SirT2 (IC₅₀=1.15 μM), and SirT5 (IC₅₀=22 μM) . Suramin sodium salt is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC₅₀=5 μM) . Suramin sodium salt is a potent SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor . Suramin sodium salt efficiently inhibits IP5K and is an antiparasitic, anti-neoplastic and anti-angiogenic agent .

HY-150506

SPR7	Parasite	Infection
SPR7 (compound 7) is a potent and selective rhodesain inhibitor, with a K_i of 0.51 nM. SPR7 shows antiparasitic activity against T. b. brucei, with an EC₅₀ of 1.65 μM .

Chrysosplenol D	Infection Flavonols Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology	Apoptosis
Chrysosplenol D is a methoxy flavonoid that induces ERK1/2-mediated apoptosis in triple negative human breast cancer cells. Chrysosplenol D also exhibits anti-inflammatory and moderate antitrypanosomal activities .

Girinimbine Girinimbin	Infection Alkaloids Classification of Application Fields Source classification Rutaceae Murraya koenigii (L.) Spreng Plants Disease Research Fields Inflammation/Immunology Indole Alkaloids	Apoptosis Bacterial Parasite
Girinimbine (Girinimbin) is a carbazole alkaloid with a variety of biological effects. Girinimbine can induce apoptosis, and has antitrypanosomal, antiplatelet activity, antibacterial activity, anti-inflammatory, antioxidant and antitumor activities .

Virustomycin A	Structural Classification Natural Products Microorganisms Source classification	Parasite
Virustomycin A is a nature product that could be isolated from Streptomyces. Virustomycin A has selective and potent antitrypanosomal activity .

Irumamycin	Structural Classification Microorganisms Antibiotics Source classification	Fungal Parasite Antibiotic
Irumamycin is a natural 20-membered macrolide antibiotic. Irumamycin is active in vitro against some phytopathogenic fungi . Irumamycin also shows potent antitrypanosomal activity .

Nucleocidin 4'-Fluoro-5'-O-sulfamoyladenosine; NSC 521007	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Anti-parasitic Disease Research Disease Research Fields Other Antibiotics	Bacterial
Nucleocidin is an antitrypanosomal antibiotic, inhibiting the transfer of labeled amino acid from S-RNA to protein.

Dehydrobruceine A	Simaroubaceae Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Inflammation/Immunology Disease Research Fields Brucea javanica (L.) Merr.	Parasite
Dehydrobruceine A is a low potent antitrypanosomal agent, with an IC₅₀ of 88.5 nM for Plasmodium falciparum .

Methylenetanshinquinone	Structural Classification Natural Products Leguminosae Labiatae Source classification Samanea saman (Jacq.) Merr. Plants	Parasite
Methylenetanshinquinone is a natural compound with antiplasmodial, antitrypanosomal and antioxidative activities. Methylenetanshinquinone can be used for the research of parasite infection .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Antitrypanosomal

Inhibitors & Agonists

NaturalProducts

Natural
Products