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Apis+mellifera

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By Targets:	Biochemical Assay Reagents (1) Herbicide (1) Insecticide (1) nAChR (1) Parasite (1) Reactive Oxygen Species (ROS) (1)
By Research Areas:	Endocrinology (1) Infection (1) Metabolic Disease (2) Neurological Disease (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-128030

Makisterone A	Others	Endocrinology
Makisterone A, a 28-carbon moulting hormone, has been identified as the major free pupal ecdysteroid in the honey bee, Apis mellifera .

HY-B2021

τ-Fluvalinate	Insecticide	Neurological Disease
τ-Fluvalinate is an insecticide and in-hive miticide, with its mechanism involving interfering with nervous systems. τ-Fluvalinate binds to the open state of Varroa destructor (VdNaV1) and Apis mellifera (AmNaV1) voltage-dependent sodium channels, with EC₅₀ values of 160 nM and 60 nM respectively. τ-Fluvalinate has higher affinity for AmNaV1, which causes sublethal toxicity to honeybees. τ-Fluvalinate can be applied for research on Varroa destructor infestation in honeybee colonies .

HY-B0827B

(S)-Dinotefuran (S)-MTI-446	nAChR Parasite	Infection
(S)-Dinotefuran ((S)-MTI-446), a neonicotinoid pesticide, is toxic by binding to α8 subunit of nAChR of honeybee Apis mellifera (Apis mellifera Linnaeus). (S)-Dinotefuran shows more toxic than R-dinotefuran to honeybee Apis mellifera .

HY-P3029D

*Phospholipase A2, Honey bee venom (Apis mellifera)*	Biochemical Assay Reagents	Metabolic Disease
Phospholipase A2, Honey bee venom (Apis mellifera) (EC 3.1.1.4) hydrolyzes the β-ester bond of zwitterionic glycerophospholipids. Preferred substrates are phosphatidylcholine, phosphatidylethanolamine, and their plasmalogen analogues.

HY-W714006

Cochliodinol	Reactive Oxygen Species (ROS)	Metabolic Disease
Cochliodinol (compound 1) is a metabolite derived from the Apis mellifera ligustica. Cochliodinol has strong free radical scavenging activity of 2, 2-diphenyl-1-picrohydrazine (DPPH) (IC₅₀=3.06 μg/mL) .

HY-W710697

Triclopyr ester Triclopyr 2-butoxyethylester	Herbicide	Others
Triclopyr ester (Triclopyr 2-butoxyethylester) is a bioactive substance with activity in controlling harmful woody plants. Triclopyr ester showed toxicity to honeybees (Apis mellifera) in greenhouse trials. Triclopyr ester in combination with other herbicides is effective in removing the canopy of plants such as honey trees and whitebrush. Triclopyr ester can quickly assess its weeding effectiveness when treating trees in greenhouses, providing potential treatment options for field experiments .

Cat. No.	Product Name	Target	Research Area

HY-P4851

Adipokinetic hormone (Manduca sexta) Manse-AKH	Peptides	Others
Adipokinetic Hormone (Apis mellifera ligustica, Bombyx mori, Heliothis zea, Manduca sexta) is a common peptide among various insects. Adipokinetic Hormone induces strong adipokinetic/hypertrehalosemic response. However Adipokinetic Hormone has no a glycogen-mobilizing function nor an adequate glycogen store in fat body for its effective utilization .

Makisterone A	Classification of Application Fields Chenopodium quinoa Willd. Plants Disease Research Fields Endocrinology Steroids Source Classification Chenopodiaceae	Others
Makisterone A, a 28-carbon moulting hormone, has been identified as the major free pupal ecdysteroid in the honey bee, Apis mellifera .

Cochliodinol	Human Gut Microbiota Metabolites Microorganisms Antibiotics Endogenous metabolite Other Antibiotics Source Classification	Reactive Oxygen Species (ROS)
Cochliodinol (compound 1) is a metabolite derived from the Apis mellifera ligustica. Cochliodinol has strong free radical scavenging activity of 2, 2-diphenyl-1-picrohydrazine (DPPH) (IC₅₀=3.06 μg/mL) .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Apis+mellifera

Inhibitors & Agonists

Peptides

NaturalProducts

Natural
Products