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Results for "

Arachidonic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) Apoptosis (5) Bacterial (1) Biochemical Assay Reagents (7) COX (5) Cytochrome P450 (4) DNA/RNA Synthesis (1) Drug Metabolite (1) DYRK (1) Endogenous Metabolite (38) Endothelin Receptor (1) ERK (1) FLAP (1) Influenza Virus (1) Integrin (1) Isotope-Labeled Compounds (9) Leukotriene Receptor (2) Liposome (1) Lipoxygenase (3) MAGL (2) Mitochondrial Metabolism (1) Na+/K+ ATPase (3) NO Synthase (1) NOD-like Receptor (NLR) (1) P2Y Receptor (1) p38 MAPK (3) Parasite (2) PGE synthase (1) Phospholipase (4) Potassium Channel (3) Prostaglandin Receptor (10) Src (1) Syk (1)
By Research Areas:	Cancer (10) Cardiovascular Disease (30) Endocrinology (6) Infection (4) Inflammation/Immunology (40) Metabolic Disease (16) Neurological Disease (8)
Click Chemistry:	Alkynes (1)

124

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-109590

Arachidonic acid Maximum Cited Publications 16 Publications Verification Immunocytophyt	Endogenous Metabolite	Inflammation/Immunology
Arachidonic acid (Immunocytophyt) is a polyunsaturated omega-6 fatty acid and a major constituent of biomembranes. Arachidonic acid also acts as the substrate for various lipid mediators, such as prostaglandins (PGs). Arachidonic acid improves cognitive response and cardiovascular function .

HY-W011297

Methyl arachidonate Arachidonic acid methyl ester	Others	Metabolic Disease
Methyl arachidonate (Arachidonic acid methyl ester) is a fatty acid methyl ester resulting from the formal condensation of the carboxy group of arachidonic acid with methanol. Methyl arachidonate has activity of human blood serum metabolite .

HY-109590A

Arachidonic acid sodium salt Immunocytophyt sodium salt	Endogenous Metabolite	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Arachidonic acid (Immunocytophyt) sodium salt is a polyunsaturated omega-6 fatty acid and a major constituent of biomembranes. Arachidonic acid sodium salt also acts as the substrate for various lipid mediators, such as prostaglandins (PGs). Arachidonic acid sodium salt improves cognitive response and cardiovascular function .

HY-109590R

Arachidonic acid (Standard) Immunocytophyt (Standard)	Endogenous Metabolite	Inflammation/Immunology
Arachidonic acid (Standard) is the analytical standard of Arachidonic acid. This product is intended for research and analytical applications. Arachidonic acid is an essential fatty acid and a major constituent of biomembranes.

HY-139285

Arachidonic acid-alkyne	Others	Metabolic Disease
Arachidonic acid-alkyne is aω‑alkynyl lipid surrogates for polyunsaturated fatty acid. Arachidonic acid-alkyne has low rates of oxidation. Arachidonic acid-alkyne can be used for tracking the polyunsaturated fatty acids .

HY-109590S1

Arachidonic acid-d5 Immunocytophyt-d₅	Endogenous Metabolite	Inflammation/Immunology
Arachidonic acid-d₅ is the deuterium labeled Arachidonic acid. Arachidonic acid is an essential fatty acid and a major constituent of biomembranes.

HY-109590S2

Arachidonic acid-d11 Immunocytophyt-d₁₁	Isotope-Labeled Compounds Endogenous Metabolite	Inflammation/Immunology
Arachidonic acid-d₁₁ is the deuterium labeled Arachidonic acid. Arachidonic acid is an essential fatty acid and a major constituent of biomembranes[1][2].

HY-109590S

Arachidonic acid-d8 1 Publications Verification Immunocytophyt-d₈	Endogenous Metabolite	Inflammation/Immunology
Arachidonic acid-d₈ is the deuterium labeled Arachidonic acid. Arachidonic acid is an essential fatty acid and a major constituent of biomembranes[1][2].

HY-W011297S1

Methyl arachidonate-d8

Arachidonic acid methyl ester-d₈
Isotope-Labeled Compounds Others

Methyl arachidonate-d₈ is the deuterium labeled Arachidonic acid methyl ester[1].
HY-W011297S

Methyl arachidonate-d5

Arachidonic acid methyl ester-d₅
Isotope-Labeled Compounds Others

Methyl arachidonate-d₅ is the deuterium labeled Arachidonic acid methyl ester[1].

Methyl arachidonate-d8 Arachidonic acid methyl ester-d₈	Isotope-Labeled Compounds	Others
Methyl arachidonate-d₈ is the deuterium labeled Arachidonic acid methyl ester[1].

Methyl arachidonate-d5 Arachidonic acid methyl ester-d₅	Isotope-Labeled Compounds	Others
Methyl arachidonate-d₅ is the deuterium labeled Arachidonic acid methyl ester[1].

HY-125140

*ω-3 Arachidonic* acid**	Others	Others
ω-3 Arachidonic acid is a poly fatty acid that is essential for growth and development in infants. ω-3 Arachidonic acid inhibits arachidenol-CoA synthetase with K_i values of 14 µM. It also inhibited arachidenol-CoA synthetase of calf brain extract with IC₅₀ values of about 5 µM .

HY-125140S

ω-3 Arachidonic Acid-d8

Isotope-Labeled Compounds Others

ω-3 Arachidonic Acid-d₈ is the deuterium labeled ω-3 Arachidonic Acid[1].

*ω-3 Arachidonic* Acid-d8**	Isotope-Labeled Compounds	Others
ω-3 Arachidonic Acid-d₈ is the deuterium labeled ω-3 Arachidonic Acid[1].

HY-120978

*Omega-3 arachidonic* acid methyl ester** ω-3 Arachidonic acid methyl ester; (all-Z)-8,11,14,17-Eicosatetraenoic acid methyl ester	Biochemical Assay Reagents	Others
omega-3 Arachidonic Acid methyl ester, mainly docosahexaenoic acid, eicosapentaenoic acid and α-Linoleic acid, represented by linoleic acid, is an essential dietary nutrient required for normal growth and development.Omega-3Methyl arachidonic acid is a rare fatty acid Omega-3Neutral fat-soluble form of arachidonic acid. Omega-3Fatty acids, as a group, were associated with reduced inflammation and autoimmune activity, as well as reduced thrombosis and platelet activation.

HY-125139

*omega-3 Arachidonic* acid ethyl ester** ω-3 Arachidonic acid ethyl ester; (all-Z)-8,11,14,17-Eicosatetraenoic acid ethyl ester	Biochemical Assay Reagents	Others
omega-3 Arachidonic Acid ethyl ester is a rare polyunsaturated fatty acid found in very small amounts in dietary sources. Omega-3 fatty acids are known to be essential for the growth and development of infants, and they protect against heart disease, blood clots, high blood pressure, and inflammatory and autoimmune diseases. In human platelet membranes, omega-3 arachidonic acid inhibits arachidonyl-CoA synthetase with a Ki of 14 μM. It also inhibits arachidonoyl-CoA synthetase in calf brain extract with an IC50 of approximately 5 μM. Omega-3 ethyl arachidonate is the more lipophilic form of the free acid.

HY-118584

Ro 12-7310

Others Inflammation/Immunology

Ro 12-7310 is a synthetic retinoid, and can inhibit arachidonic acid release .
HY-116246

5(S)-HETE lactone

Others Inflammation/Immunology

5(S)-HETE lactone is an arachidonic acid (AA) metabolite .
HY-119735

Curcolone

Others Cardiovascular Disease

Curcolone is a sesquiterpenoid that inhibits collagen-induced or arachidonic acid (AA)-induced platelet aggregation .

Ro 12-7310	Others	Inflammation/Immunology
Ro 12-7310 is a synthetic retinoid, and can inhibit arachidonic acid release .

5(S)-HETE lactone	Others	Inflammation/Immunology
5(S)-HETE lactone is an arachidonic acid (AA) metabolite .

Curcolone	Others	Cardiovascular Disease
Curcolone is a sesquiterpenoid that inhibits collagen-induced or arachidonic acid (AA)-induced platelet aggregation .

HY-112653A

(±)8-HETE	Endogenous Metabolite	Metabolic Disease
(±)8-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of Arachidonic acid (HY-109590). The biological activity of (±)8-HETE is likely to resemble that of its constituent enantiomers (8(R)-HETE and 8(S)-HETE).

HY-136500

Prostaglandin H2 PGH2	Endogenous Metabolite	Cardiovascular Disease
Prostaglandin H2 (PGH2), a potent vasoconstrictor, is produced by the conversion of Arachidonic acid (AA). Prostaglandin H2 is asubstrate for the production of Prostaglandins (PGs) and thromboxanes (TXs) .

HY-113442

6-trans-12-epi-Leukotriene B4	Endogenous Metabolite Drug Metabolite	Inflammation/Immunology
6-trans-12-epi-Leukotriene B4, an arachidonic acid metabolite, is a potent anti-inflammatory agent .

HY-113943A

9-HETE

(±)9-HETE
Endogenous Metabolite Others

9-HETE, a monohydroxy fatty acid, is the lipoxygenase metabolite of arachidonic acid (HY-109590) .
HY-141570

Lyso-PAF C-16

Others Others

Lyso-PAF C-16 is a substrate of lysoplasmalogen (LysoPls)-specific phospholipase D (LysoPLD). Lyso-PAF C-16 selective acetylates with arachidonic acid .

9-HETE (±)9-HETE	Endogenous Metabolite	Others
9-HETE, a monohydroxy fatty acid, is the lipoxygenase metabolite of arachidonic acid (HY-109590) .

Lyso-PAF C-16	Others	Others
Lyso-PAF C-16 is a substrate of lysoplasmalogen (LysoPls)-specific phospholipase D (LysoPLD). Lyso-PAF C-16 selective acetylates with arachidonic acid .

HY-145510

1,2-Dipalmitoyl-3-Arachidonoyl-rac-glycerol 1,2-Palmitin-3-Arachidonin	Others	Metabolic Disease
1,2-Dipalmitoyl-3-Arachidonoyl-rac-glycerol (1,2-Palmitin-3-Arachidonin) is a triacylglycerol containing Palmitic acid and Arachidonic acid .

HY-P3029

Phospholipase A2 PLA2	Phospholipase	Others
Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic acid (AA). Phospholipase A2 is a member of the class of heat-stable, calcium-dependent enzymes, is often used in biochemical studies .

HY-149550

1,2-Eucin(13Z)-olein

Endogenous Metabolite Metabolic Disease

1,2-Eucin(13Z)-olein (compound 48) is a triacylglycerol that contains palmitic acid,? oleic acid, and arachidonic acid .

1,2-Eucin(13Z)-olein	Endogenous Metabolite	Metabolic Disease
1,2-Eucin(13Z)-olein (compound 48) is a triacylglycerol that contains palmitic acid,? oleic acid, and arachidonic acid .

HY-12642

Diethylcarbamazine citrate	Parasite	Infection Inflammation/Immunology
Diethylcarbamazine citrate is an orally active anthropoidal compound. Diethylcarbamazine citrate is an inhibitor of arachidonic acid metabolism of filaria microfilaria. Diethylcarbamazine citrate has anti-inflammatory and antiparasitic activity .

HY-12956B

(5R)-Dinoprost Prostaglandin F2β; PGF2β	Endogenous Metabolite	Others
(5R)-Dinoprost is a metabolite produced by cyclooxygenase metabolism of arachidonic acid. (5R)-Dinoprost (Prostaglandin F2β) induces dose-dependent release of hexose containing mucin .

HY-N3048

Piperlotine D	Others	Cardiovascular Disease
Piperlotine D is an antiplatelet aggregation agent. Piperlotine D can be extracted from Piper lolot with antiplatelet aggregation activity. Piperlotine D inhibits arachidonic acid-induced platelet aggregation with an IC₅₀ of 43.4 μg/mL .

HY-113943

9(S)-HETE	Endogenous Metabolite	Others
9(S)-HETE is the S isomer of 9-HETE (HY-113943A). 9-HETE, a monohydroxy fatty acid, is the lipoxygenase metabolite of arachidonic acid (HY-109590) .

HY-114850A

(5R)-Dinoprost tromethamine Prostaglandin F2β tromethamine; PGF2β tromethamine	Endogenous Metabolite	Others
(5R)-Dinoprost tromethamine (Prostaglandin F2β tromethamine) is a metabolite produced by the metabolism of arachidonic acid cyclooxygenase. (5R)-Dinoprost tromethamine induces dose-dependent release of hexosaccharide containing mucin .

HY-W013214

Ethyl arachidonate	Endogenous Metabolite	Others
Ethyl arachidonate is a lipophilic esterified form of arachidonic acid (AA) and can be added into dietary regimens or fed to cultured cells as a source of exogenous arachidonate. Ethyl arachidonate is the main species of fatty acid ethyl esters (FAEE) in brain of alcohol-intoxicated subjects .

HY-106200

CJ-13,610	Lipoxygenase	Inflammation/Immunology
CJ-13,610, a nonredox-type 5-LO inhibitor, dose dependently suppresses 5-LO product formation in ionophore A23187-stimulated PMNL in the absence of exogenous AA with an IC₅₀ of about 70 nM . PMNL: polymorphonuclear leukocytes; AA: arachidonic acid

HY-P2976

Lipoxygenase, general LOX	Endogenous Metabolite	Others
Lipoxygenase, general (LOX) is a dioxygenase, is often used in biochemical studies. Lipoxygenase, general catalyzes the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid .

HY-143791

ALOX15-IN-2	Lipoxygenase	Inflammation/Immunology
ALOX15-IN-2 (compound 8a) is a potent inhibitor of the linoleate oxygenase activity of rabbit and human ALOX15 with _IC50s of 1.55 and 2.79 μM for ALOX15 0rthologs linoleic acid (LA) and arachidonic acid (AA), respectively .

HY-143787

ALOX15-IN-1	Lipoxygenase	Inflammation/Immunology
ALOX15-IN-1 (compound 8b) is a potent inhibitor of the linoleate oxygenase activity of rabbit and human ALOX15 with _IC50s of 0.04 and 2.06 μM for ALOX15 0rthologs linoleic acid (LA) and arachidonic acid (AA), respectively .

HY-108561

L-670596	Prostaglandin Receptor	Others
L-670596 is an orally active and selective thrombsxane A2 receptor/prostaglandin receptor antagonist. L-670596 inhibits arachidonic acid (HY-109590) and U-44069 induced bronchoconstriction in the guinea pig. L-670596 also inhibits the aggregation of human platelet rich plasma induced by U-44069 .

HY-113434A

5(R)-HETE	Others	Inflammation/Immunology
5(R)-HETE is a lipoxygenase product of arachidonic acid. 5(R)-HETE is an? inducer of neutrophil migration through endothelial and epithelial barriers. 5(R)-HETE is important in mediating lung inflammatory processes .

HY-134556

2'-Hydroxyflavanone	Apoptosis	Inflammation/Immunology Cancer
2'-Hydroxyflavanone is a flavanone that can inhibit cancer cell proliferation, induce apoptosis, and reduce inflammation. 2'-Hydroxyflavanone shows inhibitory effect on platelet aggregation caused by two inducers with IC₅₀s 47.8 μM arachidonic acid (AA) and 147.2 μM aenosine diphosphate (ADP) .

HY-105120A

Vapiprost hydrochloride	Prostaglandin Receptor	Others
Vapiprost hydrochloride is a thromboxane A2 receptor antagonist. Vapiprost inhibits the aggregation and ATP release stimulated with U-46619, collagen or arachidonic acid (AA) at an IC₅₀ of less than 2.1×10 ^-8 M .

HY-142972

19(S)-HETE	Prostaglandin Receptor	Cardiovascular Disease
19(S)-HETE is an arachidonic acid metabolite produced by cytochrome P450 enzymes. 19(S)-HETE is a full orthosteric agonist of the prostacyclin (IP) receptor with an EC₅₀ value of 567 nM. 19(S)-HETE inhibits platelet activation and relaxation of vessels .

HY-N10225

Thielavin A	Prostaglandin Receptor	Cardiovascular Disease Endocrinology
Thielavin A is an inhibitor of prostaglandin biosynthesis produced by Thielavia terricola. Thielavin A specifically inhibits the conversion of arachidonic acid into prostaglandin H2. Thielavin A has no anti-inflammatory activity on intravenous injection or on oral administration .

HY-113434B

5-HETE (±)-5-HETE	Endogenous Metabolite	Inflammation/Immunology
5-HETE ((±)-5-HETE), a fatty acid, is a oxidative derivative of Arachidonic acid. 5-HETE is a mixture of 5(S)-HETE and 5(R)-HETE. 5-HETE is a potent aggregating agent that induces the aggregation of neutrophils with an IC₅₀ value of 200 nM .

HY-116281

ICI D1542	Prostaglandin Receptor	Cardiovascular Disease
ICI D1542 is a selective and potent inhibitor of thromboxane A2 (TXA2) synthase and the thromboxane A2 receptor (TP-receptor). ICI D1542 is effective at preventing thrombus formation by redirection of arachidonic acid metabolism .

HY-113330

12S-HHT 1 Publications Verification 12(S)-HHTrE	Leukotriene Receptor Endogenous Metabolite	Inflammation/Immunology
12S-HHT (12(S)-HHTrE) is an enzymatic product of prostaglandin H₂ (PGH₂) derived from cyclooxygenase (COX)-mediated arachidonic acid metabolism. 12S-HHT is an endogenous ligand for BLT2 that fully activates BLT2 in vivo. 12S-HHT suppresses UV-induced IL-6 synthesis in keratinocytes, exerting an anti-inflammatory activity .

HY-19594

Teclozan WIN 13146	Parasite	Infection
Teclozan (WIN 13146) is an antiprotozoal agent, class in benzylamine derivatives. Teclozan intervenes in the phospholipid metabolism preventes the formation of arachidonic acid. Teclozan acts in the intestinal lumen being effective in Anti-G. intestinalis. Teclozan can be used for the research of protozoan infections .

HY-12511

SKF-86002 2 Publications Verification	p38 MAPK	Inflammation/Immunology
SKF-86002 is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 inhibits lipopolysaccharide (LPS)-stimulate human monocyte IL-1 and TNF-α production (IC₅₀ = 1 μM). SKF-86002 inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid .

HY-108641

SKF-86002 dihydrochloride	p38 MAPK	Inflammation/Immunology
SKF-86002 dihydrochloride is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 dihydrochloride inhibits lipopolysaccharide (LPS)-stimulate human monocyte IL-1 and TNF-α production (IC₅₀ = 1 μM). SKF-86002 dihydrochloride inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid .

HY-119647

PPOH	COX Cytochrome P450	Others
PPOH, a fatty acid derivative, is a selective cyclooxygenase (COX) inhibitor that inhibits arachidonic acid cyclooxygenase activity in renal cortical microsomes. In addition, PPOH acts on CYP4A2 and CYP4A3 with the IC₅₀ values of 22 μM and 6.5 μM, respectively . PPOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W133891

Peptone from soya Peptones, soybean	Biochemical Assay Reagents	Others
Peptone from soya (Peptones, soybean) is a peptone that is commonly used as a component of culture medium. Peptone from soya can be used in microbiology and cell culture to provide needed sources of nitrogen, carbon and other nutrients. Peptone from soya stimulates/regulates cyclic arachidonic acid biosynthesis. Peptone from soya also exerts enteric cell activity in jejunum of piglets through this mechanism .

HY-116141

7-Hydroxycoumarinyl arachidonate 7-HCA; Umbelliferyl Arachidonate; 7-HC-arachidonate	Phospholipase MAGL	Others
7-Hydroxycoumarinyl arachidonate (7-HCA) is a fluorogenic substrate of cytosolic phospholipase A2 (PLA2). 7-Hydroxycoumarinyl arachidonate is also a fluorogenic substrate for monoacylglycerol lipase (MAGL). MAGL protein catalyzes the hydrolysis of 7-Hydroxycoumarinyl arachidonat to generate Arachidonic acid (AA) and the highly fluorescent 7-hydroxyl coumarin (7-HC; HY-N0573). Release of 7-HC can be measured using a fluorometer .

Cat. No.	Product Name	Type

HY-W133891

Peptone from soya

Peptones, soybean

Biochemical Assay Reagents

Peptone from soya (Peptones, soybean) is a peptone that is commonly used as a component of culture medium. Peptone from soya can be used in microbiology and cell culture to provide needed sources of nitrogen, carbon and other nutrients. Peptone from soya stimulates/regulates cyclic arachidonic acid biosynthesis. Peptone from soya also exerts enteric cell activity in jejunum of piglets through this mechanism .

HY-120978

Omega-3 arachidonic acid methyl ester

ω-3 Arachidonic acid methyl ester; (all-Z)-8,11,14,17-Eicosatetraenoic acid methyl ester

Biochemical Assay Reagents

omega-3 Arachidonic Acid methyl ester, mainly docosahexaenoic acid, eicosapentaenoic acid and α-Linoleic acid, represented by linoleic acid, is an essential dietary nutrient required for normal growth and development.Omega-3Methyl arachidonic acid is a rare fatty acid Omega-3Neutral fat-soluble form of arachidonic acid. Omega-3Fatty acids, as a group, were associated with reduced inflammation and autoimmune activity, as well as reduced thrombosis and platelet activation.

HY-125139

omega-3 Arachidonic acid ethyl ester

ω-3 Arachidonic acid ethyl ester; (all-Z)-8,11,14,17-Eicosatetraenoic acid ethyl ester

Biochemical Assay Reagents

omega-3 Arachidonic Acid ethyl ester is a rare polyunsaturated fatty acid found in very small amounts in dietary sources. Omega-3 fatty acids are known to be essential for the growth and development of infants, and they protect against heart disease, blood clots, high blood pressure, and inflammatory and autoimmune diseases. In human platelet membranes, omega-3 arachidonic acid inhibits arachidonyl-CoA synthetase with a Ki of 14 μM. It also inhibits arachidonoyl-CoA synthetase in calf brain extract with an IC50 of approximately 5 μM. Omega-3 ethyl arachidonate is the more lipophilic form of the free acid.

HY-P3029

Phospholipase A2 PLA2	Biochemical Assay Reagents
Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic acid (AA). Phospholipase A2 is a member of the class of heat-stable, calcium-dependent enzymes, is often used in biochemical studies .

HY-134428

Arachidonoyl coenzyme A lithium	Biochemical Assay Reagents
Arachidonoyl coenzyme A lithium is an unsaturated fatty acyl coenzyme A, formed by the condensation of the thiol group of coenzyme A with the carboxyl group of arachidonic acid .

HY-124187

Pinolenic acid ethyl ester

Ethyl pinolenate

Biochemical Assay Reagents

Pinolenic acid is a polyunsaturated fatty acid found in the seed oils of red pine (Pinus orientalis) and maritime pine (Pinus pinaster). Both oils were found to have lipid-lowering properties. A diet containing marine pine nut oil (MPSO) reduces HDL and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was found to reduce cholesterol efflux in vitro. Korean pine nut oil supplements may help obesity by reducing appetite. People who take this oil experience an increase in the satiety hormones CCK and GLP-1 and a decrease in appetite. The activity of the oil is attributed to pinolenic acid. Pinolenic acid is not metabolized to arachidonic acid and can reduce the level of arachidonic acid in the phosphatidylinositol fraction of HepG2 cells from 15.9% to 7.0%. Pinolenic acid ethyl ester is a neutral, more lipophilic form of the free acid.

HY-N7833

(all-Z)-6,9,12,15,18-Heneicosapentaenoic Acid

Heneicosapentaenoic acid

Biochemical Assay Reagents

Heneicosapentaenoic Acid (HPA) is a 21:5 omega-3 fatty acid found in trace amounts in the green alga B. pennata and in fish oils. Its chemical composition is similar to eicosapentaenoic acid (EPA), except that a carbon is extended at the carboxy terminus, placing the first double bond at the δ6 position. HPA can be used to study the importance of double bond position in omega-3 fatty acids. It incorporates phospholipids and triacylglycerols in vivo with the same efficiency as EPA and docosahexaenoic acid, and exhibits a strong inhibitory effect on the synthesis of arachidonic acid from linoleic acid. HPA is a poor substrate for prostaglandin H synthase (PGHS) (cyclooxygenase) and 5-lipoxygenase, but retains the ability to rapidly inactivate PGHS.

HY-N7864

all-cis-4,7,10,13,16-Docosapentaenoic acid

all-cis-4,7,10,13,16-Docosapentaenoic acid; Osbond acid

Biochemical Assay Reagents

Docosapentaenoic acid (DPA) is a 22-carbon fatty acid found in fish oil. It is a minor component of total serum unsaturated fatty acids in humans, ranging from 0.1% to 1%, and increasing with dietary supplementation. all-cis-4,7,10,13,16-DPA, also known as Austrian acid, is an isomer of DPA. It is an omega-6 fatty acid formed by the extension and desaturation of arachidonic acid. During fatty acid desaturase syndrome, levels of this fatty acid may be reduced, which may affect development. Upregulated hepatic elongate expression of very long fatty acid protein 6 and elevated levels of very long chain fatty acids, including all-cis 4,7,10,13,16-DPA, are characteristic of nonalcoholic steatohepatitis, a precancerous disease of hepatocellular carcinoma.

HY-131384

8,11,14-Eicosatriynoic acid

8,11,14-Icosatriynoic acid

Biochemical Assay Reagents

8,11,14-Eicosatriynoic Acid, as an inhibitor of prostaglandin, leukotriene biosynthesis, and arachidonic acid-induced platelet aggregation, blocks human 12-lipoxygenase (12-LO), cyclooxygenase (COX)and 5-lipoxygenase (5-LO) with IC50 values of 0.46 μM, 14 μMand 25 μM, respectively. In addition, 8,11,14-Eicosatriynoic Acid inhibits the action of slow-reacting substances of allergic reactions, with IC50 value of 10 μM. Lipoxygenase is widely found in fungi, plants and animals. 12-LO involves in many important disease states and may play a role in oxidative glutamate toxicity. COX enzymes play complex roles in human physiology and pathology involving the neuronal, immune, renal, cardiovascular, gastrointestinal and reproductive systems. COX enzymes are blocked by aspirin and a variety of other NSAIDs, which makes them clinically important. 5-LO involves in cancer pathology. It is expressed by a variety of cancer cells, including colon, lung, breast, and prostate cancers, and promotes cancer cell growth and neovascularization . 8,11,14-Eicosatriynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-109590

Arachidonic acid Maximum Cited Publications 16 Publications Verification Immunocytophyt	Structural Classification Human Gut Microbiota Metabolites Microorganisms Animals Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
Arachidonic acid (Immunocytophyt) is a polyunsaturated omega-6 fatty acid and a major constituent of biomembranes. Arachidonic acid also acts as the substrate for various lipid mediators, such as prostaglandins (PGs). Arachidonic acid improves cognitive response and cardiovascular function .

HY-109590R

Arachidonic acid (Standard) Immunocytophyt (Standard)	Structural Classification Classification of Application Fields Animals Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
Arachidonic acid (Standard) is the analytical standard of Arachidonic acid. This product is intended for research and analytical applications. Arachidonic acid is an essential fatty acid and a major constituent of biomembranes.

HY-112653A

(±)8-HETE	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
(±)8-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of Arachidonic acid (HY-109590). The biological activity of (±)8-HETE is likely to resemble that of its constituent enantiomers (8(R)-HETE and 8(S)-HETE).

HY-113442

6-trans-12-epi-Leukotriene B4	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite Drug Metabolite
6-trans-12-epi-Leukotriene B4, an arachidonic acid metabolite, is a potent anti-inflammatory agent .

HY-149550

1,2-Eucin(13Z)-olein	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
1,2-Eucin(13Z)-olein (compound 48) is a triacylglycerol that contains palmitic acid,? oleic acid, and arachidonic acid .

HY-12956B

(5R)-Dinoprost Prostaglandin F2β; PGF2β	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
(5R)-Dinoprost is a metabolite produced by cyclooxygenase metabolism of arachidonic acid. (5R)-Dinoprost (Prostaglandin F2β) induces dose-dependent release of hexose containing mucin .

HY-N3048

Piperlotine D	Structural Classification Alkaloids Pyrrole Alkaloids Piper sarmentosum Roxb. Source classification Piperaceae Plants	Others
Piperlotine D is an antiplatelet aggregation agent. Piperlotine D can be extracted from Piper lolot with antiplatelet aggregation activity. Piperlotine D inhibits arachidonic acid-induced platelet aggregation with an IC₅₀ of 43.4 μg/mL .

HY-W013214

Ethyl arachidonate	Structural Classification Natural Products Source classification Endogenous metabolite	Endogenous Metabolite
Ethyl arachidonate is a lipophilic esterified form of arachidonic acid (AA) and can be added into dietary regimens or fed to cultured cells as a source of exogenous arachidonate. Ethyl arachidonate is the main species of fatty acid ethyl esters (FAEE) in brain of alcohol-intoxicated subjects .

HY-134556

2'-Hydroxyflavanone	Structural Classification Flavonoids Mimosa pudica Linn. Leguminosae Flavonones Source classification Plants	Apoptosis
2'-Hydroxyflavanone is a flavanone that can inhibit cancer cell proliferation, induce apoptosis, and reduce inflammation. 2'-Hydroxyflavanone shows inhibitory effect on platelet aggregation caused by two inducers with IC₅₀s 47.8 μM arachidonic acid (AA) and 147.2 μM aenosine diphosphate (ADP) .

HY-N10225

Thielavin A	Cardiovascular Disease Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Disease Research Fields	Prostaglandin Receptor
Thielavin A is an inhibitor of prostaglandin biosynthesis produced by Thielavia terricola. Thielavin A specifically inhibits the conversion of arachidonic acid into prostaglandin H2. Thielavin A has no anti-inflammatory activity on intravenous injection or on oral administration .

HY-113434B

5-HETE (±)-5-HETE	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
5-HETE ((±)-5-HETE), a fatty acid, is a oxidative derivative of Arachidonic acid. 5-HETE is a mixture of 5(S)-HETE and 5(R)-HETE. 5-HETE is a potent aggregating agent that induces the aggregation of neutrophils with an IC₅₀ value of 200 nM .

HY-113330

12S-HHT 1 Publications Verification 12(S)-HHTrE	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Leukotriene Receptor Endogenous Metabolite
12S-HHT (12(S)-HHTrE) is an enzymatic product of prostaglandin H₂ (PGH₂) derived from cyclooxygenase (COX)-mediated arachidonic acid metabolism. 12S-HHT is an endogenous ligand for BLT2 that fully activates BLT2 in vivo. 12S-HHT suppresses UV-induced IL-6 synthesis in keratinocytes, exerting an anti-inflammatory activity .

HY-N9676

Kaempferol 3-O-(2'',4''-di-acetyl-3''-cis-p-coumaroyl-6''-trans-p-coumaroyl)-β-D-glucopyranoside	Structural Classification Flavonoids Flavones Source classification Quercus dentata Thunb. Plants Fagaceae	Others
Kaempferol 3-O-(2'',4''-di-acetyl-3''-cis-p-coumaroyl-6''-trans-p-coumaroyl)-β-D-glucopyranoside is a flavonoid compound that can be isolated from Quercus dentata. Kaempferol 3-O-(2'',4''-di-acetyl-3''-cis-p-coumaroyl-6''-trans-p-coumaroyl)-β-D-glucopyranoside suppresses the superoxide generation induced by arachidonic acid .

HY-113350

Thromboxane A2 TXA2	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Endocrinology Cancer	Prostaglandin Receptor Endogenous Metabolite
Thromboxane A2 (TXA2) is a prostanoid mediator produced by the metabolism of Arachidonic acid (HY-109590) through the cyclooxygenase pathway. Thromboxane A2 activates the thromboxane-prostanoid (TP) receptors. Thromboxane A2 is a potent vasoconstrictor eicosanoid. Thromboxane A2 (TXA2) leads to potent vasoconstriction by stimulation of smooth muscle cells. Thromboxane A2 acts as s tonic immunoregulator to regulate adaptive immune responses .

HY-113453

11(R)-HETE	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
11(R)-HETE is a kind of arachidonic acid .

HY-N5061

Rotundatin	Cardiovascular Disease Classification of Application Fields Orchidaceae Source classification Phenols Polyphenols Plants Disease Research Fields Liparis regnieri Finet	Others
Rotundatin is useful in inhibition of the aggregation of platelets induced by arachidonic acid and collagen .

HY-W004260

Arachidic acid 1 Publications Verification Eicosanoic acid	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Arachidonic acid (Icosanoic acid), an orally active long-chain fatty acid, is present in all mammalian cells, typically esterified to membrane phospholipids, and is one of the most abundant polyunsaturated fatty acids present in human tissue. Moreover, Arachidonic acid is an important mediator of inflammation .

HY-134428

Arachidonoyl coenzyme A lithium	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Arachidonoyl coenzyme A lithium is an unsaturated fatty acyl coenzyme A, formed by the condensation of the thiol group of coenzyme A with the carboxyl group of arachidonic acid .

HY-N3049

Piperlotine C	Cardiovascular Disease Alkaloids Pyrrole Alkaloids Classification of Application Fields Source classification Piperaceae Plants Disease Research Fields Piper nigrum Linn.	Others
Piperlotine C is an alkaloid isolated from Piper lolot, with anti-platelet aggregation induced by arachidonic acid, and the IC₅₀ is 26.6 µg/mL .

HY-N12514

Cyclomulberrin	Structural Classification Flavonoids Source classification Plants Moraceae Other Flavonoids Morus alba Linn.	Others
Cyclomulberrin is a extended flavonoid that shows inhibition of arachidonic acid (AA)- and collagen-induced platelet aggregation, with IC₅₀ value of 128.2 μM .

HY-N1861

3-O-Methylquercetin tetraacetate Quercetin 3-O-methyl ether peracetate	Rhamnus nakaharai (Hayata) Hayata Structural Classification Flavonoids Flavones Source classification Plants Rhamnaceae	P2Y Receptor
3-O-Methylquercetin tetraacetate is an antiplatelet agent. 3-O-Methylquercetin tetraacetate has potent antiplatelet effect on arachidonic acid, collagen-induced and PAF-induced platelet aggregation .

HY-N2478

Taraxasteryl acetate	Triterpenes Classification of Application Fields Terpenoids Source classification Astragalus oleifolius DC. Plants Compositae Disease Research Fields Inflammation/Immunology	Others
Taraxasteryl acetate is isolated from P. sagittalis,and has a broad spectrum of anti-inflammatory activity. Taraxasteryl acetate relieves dextran, zymosan and arachidonic acid induced rat hind-paw edema. Taraxasteryl acetate can be used for the topical inflammation treatment ^{[1] ^.}

HY-125770

5(S)-HPETE	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
5(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of 5-LO on arachidonic acid. 5(S)-HpETE is metabolized to leukotriene A4 (LTA4), a key intermediate in the formation of LTs.

HY-W004260R

Arachidic acid (Standard) 1 Publications Verification Eicosanoic acid (Standard)	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Arachidic acid (Standard) is the analytical standard of Arachidic acid. This product is intended for research and analytical applications. Arachidonic acid (Icosanoic acid), a long-chain fatty acid, is present in all mammalian cells, typically esterified to membrane phospholipids, and is one of the most abundant polyunsaturated fatty acids present in human tissue .

HY-N2892

Aristolactam A IIIa Aristololactam A IIIa; Sch 546909	Structural Classification Antibiotics Fissistigma balansae (A. DC.) Merr. Source classification Disease Research Plants Annonaceae Anticancer Other Antibiotics	DYRK
Aristolactam A IIIa (Sch 546909) is an aristolactam-type alkaloid that can be isolated from Glycosmis chlorosperma. Aristolactam A IIIa is a DYRK1A Inhibitor. Aristolactam A IIIa inhibits platelet aggregation induced by arachidonic acid (AA), collagen and platelet-activating factor (PAF). Aristolactam A IIIa has strong cytotoxic effect on HeLa cells .

HY-124404A

12(S)-HETE	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	ERK DNA/RNA Synthesis p38 MAPK
12(S)-HETE is the 12-lipoxygenase metabolite of arachidonic acid and has a mitogenic effect on cancer cell proliferation. 12(S)-HETE induces tyrosine phosphorylation of cellular proteins, promotes ERK and P38 MAPK phosphorylation, increases DNA synthesis, and stimulates the proliferation of pancreatic cancer cells .

HY-113209

8-Isoprostaglandin F2α	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
8-Isoprostaglandin F2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. 8-Isoprostaglandin F2α is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. 8-Isoprostaglandin F2α is a weak TP receptor agonist in vascular smooth muscle.

HY-125396

11-Deoxyprostaglandin F2β 11-Deoxy-PGF2β	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
11-Deoxyprostaglandin F2β (11-deoxy PGF2β) is an analog of PGF2β (HY-12956B). PGF2β is a metabolite produced by cyclooxygenase metabolism of arachidonic acid. PGF2β induces dose-dependent release of hexose containing mucin .

HY-N4237

Saikogenin D	Triterpenes Classification of Application Fields Terpenoids Source classification Plants Umbelliferae Disease Research Fields Inflammation/Immunology Carphephorus corymbosus (Nutt.) Torr. & A.Gray	Prostaglandin Receptor Potassium Channel
Saikogenin D is isolated from Bupleurum chinense, has anti-inflammatory effects. Saikogenin D activates epoxygenases that converts arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids, and the metabolites secondarily inhibit prostaglandin E2 (PGE2) production. Saikogenin D results in an elevation of [Ca ²⁺]i due to Ca ²⁺ release from intracellular stores .

HY-150084

(±)14,15-Epoxyeicosatrienoic acid (±)14(15)-EET	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Cytochrome P450
(±)14,15-Epoxyeicosatrienoic acid ((±)14(15)-EET) is the Cytochrome P450 metabolite of arachidonic acid. While CYP3A4 may be involved in breast cancer cell growth, (±)14,15-Epoxyeicosatrienoic acid may promote mitosis and anchorage-dependent cloning through STAT3 affected by CYP3A4. (±)14,15-Epoxyeicosatrienoic acid exhibits STAT3-dependent cell growth promotion and may also participate in the autocrine/paracrine pathway that drives cell growth .

HY-N3848

Ermanin	Cardiovascular Disease Flavonols Structural Classification Classification of Application Fields Source classification Plants Curcuma phaeocaulis Valeton Flavonoids Phenols Polyphenols Inflammation/Immunology Disease Research Fields Zingiberaceae	Bacterial COX NO Synthase Influenza Virus
Ermanin is a flavonoid isolated from Tanacetum microphyllum. Ermanin potently inhibits iNOS, COX-2 activities, and inhibits platelet aggregation. Ermanin has anti-inflammatory, anti-tuberculous and anti-viral/bacterial properties .

HY-N0729

Linoleic acid 5+ Cited Publications	Cardiovascular Disease Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Endogenous metabolite Disease Research Fields Biological Pesticide Research Agricultural Research	Endogenous Metabolite
Linoleic acid is a common polyunsaturated (PUFA) found in plant-based oils, nuts and seeds. Linoleic acid is a part of membrane phospholipids, and functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism .

Cat. No.	Product Name	Chemical Structure

HY-109590S1

Arachidonic acid-d5

Arachidonic acid-d₅ is the deuterium labeled Arachidonic acid. Arachidonic acid is an essential fatty acid and a major constituent of biomembranes.
HY-109590S2

Arachidonic acid-d11

Arachidonic acid-d₁₁ is the deuterium labeled Arachidonic acid. Arachidonic acid is an essential fatty acid and a major constituent of biomembranes[1][2].

HY-109590S

Arachidonic acid-d8 1 Publications Verification
Arachidonic acid-d₈ is the deuterium labeled Arachidonic acid. Arachidonic acid is an essential fatty acid and a major constituent of biomembranes[1][2].

HY-W011297S1

Methyl arachidonate-d8

Methyl arachidonate-d₈ is the deuterium labeled Arachidonic acid methyl ester[1].
HY-W011297S

Methyl arachidonate-d5

Methyl arachidonate-d₅ is the deuterium labeled Arachidonic acid methyl ester[1].
HY-125140S

ω-3 Arachidonic Acid-d8

ω-3 Arachidonic Acid-d₈ is the deuterium labeled ω-3 Arachidonic Acid[1].

HY-W004260S1

Arachidic acid-d39
Arachidic acid-d₃₉ is the deuterium labeled Arachidic acid. Arachidonic acid (Icosanoic acid), a long-chain fatty acid, is present in all mammalian cells, typically esterified to membrane phospholipids, and is one of the most abundant polyunsaturated fatty acids present in human tissue[1][2].

HY-W004260S

Arachidic acid-d2
Arachidic acid-d₂ is the deuterium labeled Arachidic acid. Arachidonic acid (Icosanoic acid), a long-chain fatty acid, is present in all mammalian cells, typically esterified to membrane phospholipids, and is one of the most abundant polyunsaturated fatty acids present in human tissue[1][2].

HY-W004260S2

Arachidic acid-d3
Arachidic acid-d₃) is the deuterium labeled Arachidic acid. Arachidonic acid (Icosanoic acid), a long-chain fatty acid, is present in all mammalian cells, typically esterified to membrane phospholipids, and is one of the most abundant polyunsaturated fatty acids present in human tissue[1][2].

HY-W004260S3

Arachidic acid-13C
Arachidic acid- ¹³C is the ¹³C labeled Arachidic acid. Arachidonic acid (Icosanoic acid), a long-chain fatty acid, is present in all mammalian cells, typically esterified to membrane phospholipids, and is one of the most abundant polyunsaturated fatty acids present in human tissue[1][2][3].

HY-W004260S4

Arachidic acid-d4
Arachidic acid-d₄ is the deuterium labeled Arachidic acid. Arachidonic acid (Icosanoic acid), a long-chain fatty acid, is present in all mammalian cells, typically esterified to membrane phospholipids, and is one of the most abundant polyunsaturated fatty acids present in human tissue[1][2].

HY-W004260S5

Arachidic acid-d4-1
Arachidic acid-d₄-1 is the deuterium labeled Arachidic acid[1]. Arachidonic acid (Icosanoic acid), a long-chain fatty acid, is present in all mammalian cells, typically esterified to membrane phospholipids, and is one of the most abundant polyunsaturated fatty acids present in human tissue[2][3].

HY-113209S1

8-iso Prostaglandin F2α-d9

8-iso Prostaglandin F2α-d₉ is the deuterium labeled 8-Isoprostaglandin F2α. 8-Isoprostaglandin F2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. 8-Isoprostaglandin F2α is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. 8-Isoprostaglandin F2α is a weak TP receptor agonist in vascular smooth muscle.

HY-113439S

12-HETE-d8
12-HETE-d₈ is the deuterium labeled 12-HETE. 12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway[1].12-HETE has both anti-thrombotic and pro-thrombotic effects[2]. 12-HETE is a neuromodulator[3].

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