Arginase

By Targets:	Arginase (14) Apoptosis (2) Bacterial (1) Endogenous Metabolite (3) Parasite (1)
By Research Areas:	Cancer (10) Infection (2) Inflammation/Immunology (3) Metabolic Disease (6)

Targets Recommended: Arginase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15775

Arginase inhibitor 1

4 Publications Verification

Arginase Cancer

Arginase inhibitor 1 is a potent inhibitor of human arginases I and II with IC₅₀s of 223 and 509 nM, respectively.

Arginase inhibitor 1 4 Publications Verification	Arginase	Cancer
Arginase inhibitor 1 is a potent inhibitor of human arginases I and II with IC₅₀s of 223 and 509 nM, respectively.

HY-P3190

Arginase, Microorganism L-Arginine amidinase	Endogenous Metabolite	Metabolic Disease
Arginase, Microorganism (L-Arginine amidinase) is an enzyme of the urea cycle. Arginase catalyzes the hydrolysis of L-arginine to L-ornithine and urea .

HY-112885C

nor-NOHA dihydrochloride 1 Publications Verification Nω-Hydroxy-nor-L-arginine dihydrochloride	Apoptosis Arginase	Metabolic Disease Inflammation/Immunology Cancer
nor-NOHA dihydrochloride is a selective and reversible *arginase* inhibitor. nor-NOHA dihydrochloride induces apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA dihydrochloride has anti-leukemic activity. nor-NOHA dihydrochloride can used in study endothelial dysfunction, immunosuppression and metabolism .

HY-112885B

nor-NOHA monoacetate 1 Publications Verification Nω-Hydroxy-nor-L-arginine monoacetate	Arginase	Metabolic Disease
nor-NOHA monoacetate is a selective and reversible *arginase* inhibitor. nor-NOHA monoacetate induces apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA monoacetate has anti-leukemic activity. nor-NOHA monoacetate can used in study of endothelial dysfunction, immunosuppression and metabolism .

HY-161061

Arginase inhibitor 7	Arginase	Cancer
Arginase inhibitor 7 (compound A17) is an arginase (ARG1) inhibitor, with an IC₅₀ of 0.16 μM. Arginase inhibitor 7 has high oral bioavailability .

HY-129476

L-Canaline	Parasite Endogenous Metabolite	Infection Cancer
L-Canaline is a nonprotein amino acid stored in many leguminous plants. L-Canaline is a cytotoxic metabolite catalyzed by L-canavanine and its arginase. L-Canaline is a potent and irreversible inhibitor of ornithine aminotransferase. L-Canaline inhibits the growth of the malaria parasite *Plasmodium falciparum* with an IC₅₀ of 297 nM. L-Canaline has anticancer and antiproliferative effects .

HY-W062216

2-Aminoimidazole	Bacterial Arginase	Infection
2-Aminoimidazole is a potent antibiofilm agent that can be used as an adjuvant to antimicrobial. 2-aminoimidazoles disrupts the ability of bacteria to protect themselves by inhibiting biofilm formation and genetically-encoded antibiotic resistance traits. 2-Aminoimidazole is also a weak noncompetitive inhibitor of *human arginase* I with a K_i** of 3.6 mM .

HY-101979A

Numidargistat dihydrochloride Maximum Cited Publications 6 Publications Verification CB-1158 dihydrochloride; INCB01158 dihydrochloride	Arginase	Cancer
Numidargistat (CB-1158) dihydrochloride is a potent and orally active inhibitor of *arginase, with IC₅₀s of 86 nM and 296 nM for recombinant human arginase* 1 and recombinant human arginase 2**, respectively. Immuno-oncology agent .

HY-101979

Numidargistat Maximum Cited Publications 6 Publications Verification CB-1158; INCB01158	Arginase	Cancer
Numidargistat (CB-1158) is a potent and orally active inhibitor of *arginase, with IC₅₀s of 86 nM and 296 nM for recombinant human arginase* 1 and recombinant human arginase 2**, respectively. Immuno-oncology agent .

HY-N2237

Piceatannol 3'-O-glucoside Quzhaqigan
Piceatannol 3'-O-glucoside, an active component of Rhubarb, activates endothelial nitric oxide (NO) synthase through inhibition of arginase activity with IC₅₀s of 11.22 µM and 11.06 µM against arginase I and arginase II, respectively.

HY-155108

OATD-02	Arginase	Cancer
OATD-02 is an orally active, competitive, reversible, noncovalent dual inhibitor of *Arginase1* and 2. OATD-02 is a slow offset inhibitor, blocking intracellular arginases with IC₅₀s of 20 nM (hARG1), 39 nM (hARG2), 39 nM (mARG1), and 28 nM (rARG1), respectively. OATD-02 abolishes tumor immunosuppression induced by both arginases. OATD-02 can be used for melanoma study .

HY-W010510

DL-Norvaline

2-Aminopentanoic acid
Endogenous Metabolite Arginase Metabolic Disease

DL-Norvaline, a derivative of L-norvaline, L-norvaline is a non-competitive inhibitor of arginase.
HY-112868B

ABH hydrochloride

Arginase Inflammation/Immunology

ABH (hydrochloride) is a potent arginase inhibitor. ABH (hydrochloride) can be used for researching anti-inflammation .
HY-145331

ARG1-IN-1

Arginase Cancer

ARG1-IN-1 (example 1) is a human arginase 1 inhibitor with an IC₅₀ of 29 nM .
HY-145331A

ARG1-IN-1 hydrochloride

Arginase Cancer

ARG1-IN-1 (example 1) hydrochloride is a human arginase 1 inhibitor with an IC₅₀ of 29 nM .

DL-Norvaline 2-Aminopentanoic acid	Endogenous Metabolite Arginase	Metabolic Disease
DL-Norvaline, a derivative of L-norvaline, L-norvaline is a non-competitive inhibitor of arginase.

ABH hydrochloride	Arginase	Inflammation/Immunology
ABH (hydrochloride) is a potent *arginase* inhibitor. ABH (hydrochloride) can be used for researching anti-inflammation .

ARG1-IN-1	Arginase	Cancer
ARG1-IN-1 (example 1) is a human arginase 1 inhibitor with an IC₅₀ of 29 nM .

ARG1-IN-1 hydrochloride	Arginase	Cancer
ARG1-IN-1 (example 1) hydrochloride is a human arginase 1 inhibitor with an IC₅₀ of 29 nM .

HY-19548A

BEC hydrochloride 1 Publications Verification	Arginase	Metabolic Disease
BEC hydrochloride is a slow-binding and competitive Arginase II inhibitor with K_i of 0.31 μM and 30 nM at pH 7.5 and pH 9.5, respectively .

HY-19548

BEC
BEC, an arginine analogue, is a slow-binding competitive inhibitor of the binuclear manganese metalloenzyme arginase. BEC enhances substrate flux to NO synthase, thereby enhancing NO-dependent smooth muscle relaxation in the corpus cavernosum, and enhances penile erection .

HY-112885A

nor-NOHA acetate Nω-Hydroxy-nor-L-arginine acetate	Arginase Apoptosis	Metabolic Disease Inflammation/Immunology Cancer
nor-NOHA acetate (Nω-Hydroxy-nor-L-arginine acetate) is a specific and reversible *arginase* inhibitor, induces apoptosis in ARG2-expressing cells under hypoxia but not normoxia. Anti-leukemic activity, effective in endothelial dysfunction, immunosuppression and metabolism .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-129476

L-Canaline	Infection Structural Classification other families Classification of Application Fields Source classification Amino acids Plants Endogenous metabolite Disease Research Fields	Parasite Endogenous Metabolite
L-Canaline is a nonprotein amino acid stored in many leguminous plants. L-Canaline is a cytotoxic metabolite catalyzed by L-canavanine and its arginase. L-Canaline is a potent and irreversible inhibitor of ornithine aminotransferase. L-Canaline inhibits the growth of the malaria parasite *Plasmodium falciparum* with an IC₅₀ of 297 nM. L-Canaline has anticancer and antiproliferative effects .

HY-W062216

2-Aminoimidazole	Infection Natural Products Classification of Application Fields Animals Source classification Disease Research Fields	Bacterial Arginase
2-Aminoimidazole is a potent antibiofilm agent that can be used as an adjuvant to antimicrobial. 2-aminoimidazoles disrupts the ability of bacteria to protect themselves by inhibiting biofilm formation and genetically-encoded antibiotic resistance traits. 2-Aminoimidazole is also a weak noncompetitive inhibitor of *human arginase* I with a K_i** of 3.6 mM .

HY-W010510

DL-Norvaline 2-Aminopentanoic acid	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Arginase
DL-Norvaline, a derivative of L-norvaline, L-norvaline is a non-competitive inhibitor of arginase.

Species:	Human (4) Mouse (2)
Tag:	SUMO (1) His (6)
Source:	HEK293 (1) P. pastoris (1) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P72090

	Arginase-2/ARG2 Protein, Mouse (His-SUMO) Arg2Arginase-2; mitochondrial; EC 3.5.3.1; Arginase II; Kidney-type Arginase; Non-hepatic Arginase; Type II Arginase	Mouse	E. coli
	Arginase-2 (ARG2) is a multifunctional regulator central to the regulation of arginine metabolism and nitric oxide synthesis outside the urea cycle. In addition to its hepatic effects, ARG2 affects innate and adaptive immune responses, negatively affecting the survival of activated CD4(+) and CD8(+) T cells. Arginase-2/ARG2 Protein, Mouse (His-SUMO) is the recombinant mouse-derived Arginase-2/ARG2 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of Arginase-2/ARG2 Protein, Mouse (His-SUMO) is 332 a.a., with molecular weight of ~52.4 kDa.

HY-P71833

	Arginase-1/ARG1 Protein, Mouse (P.pastoris, His) Arg1Arginase-1; EC 3.5.3.1; Liver-type Arginase; Type I Arginase	Mouse	P. pastoris
	Arginase-1 (ARG1) plays a key role in the urea cycle, converting L-arginine into urea and L-ornithine. This cycle maintains L-arginine homeostasis, which is critical for nitric oxide synthase to compete for arginine. Arginase-1/ARG1 Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived Arginase-1/ARG1 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of Arginase-1/ARG1 Protein, Mouse (P.pastoris, His) is 323 a.a., with molecular weight of ~36.8 kDa.

HY-P7603

	Arginase-2/ARG2 Protein, Human (His) rHuArginase-2, His; ARG2; Arginase-2	Human	E. coli
	Arginase-2/ARG2 Protein, Human (His) expresses in E. coli with a His tag at the N-terminus. Arginase-2 (Arg2) acts as a fasting-induced hepatocyte factor that protects against hepatic and peripheral fat accumulation, hepatic inflammatory responses, and insulin and glucose intolerance in obese murine models.

HY-P7541

	Arginase-1/ARG1 Protein, Human (C-His) rHuArginase-1, His; ARG1; Arginase-1	Human	E. coli
	Arginase-1 Protein, Human (C-His) expresses in E. coli with a His tag at the C-terminus. Arginase-1 Protein inhibits the growth of the arginine-depleting enzyme arginine deiminase (ADI)-resistant Hep3B tumor cells in mice.

HY-P7541A

	Arginase-1/ARG1 Protein, Human (N-His) rHuArginase-1, His; ARG1; Arginase-1	Human	E. coli
	Arginase-1 (ARG1) protein, crucial in the urea cycle, converts L-arginine to urea and L-ornithine. ARG1 also regulates L-arginine levels outside the liver, impacting immune responses. ARG1's release by granulocytes suppresses T cell and NK cell functions. In ILC2s, ARG1 promotes lung inflammation. However, ARG1's role in human monocytic/macrophage/dendritic cells is unclear. Arginase-1/ARG1 Protein, Human (N-His) is the recombinant human-derived Arginase-1/ARG1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of Arginase-1/ARG1 Protein, Human (N-His) is 322 a.a., with molecular weight of ~40 kDa.

HY-P7602

	Arginase-1/ARG1 Protein, Human (HEK293, His) rHuArginase-1, His; ARG1; Arginase-1	Human	HEK293
	Arginase-1 Protein, Human (HEK293, His) expresses in HEK293 cells with a His tag at the C-terminus. Arginase-1 Protein inhibits the growth of the arginine-depleting enzyme arginine deiminase (ADI)-resistant Hep3B tumor cells in mice.


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Cat. No.	Product Name	Application	Reactivity

HY-P80019

Arginase-1 Antibody	WB, IHC-P	Human
Arginase-1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 35 kDa, targeting to Arginase-1. It can be used for WB,IHC-P assays with tag free, in the background of Human.

HY-P83148

Arginase 2 Antibody (YA2893)

ARG2; Arginase-2; Type II Arginase
WB, ICC/IF, FC Human

HY-P80745

*Liver Arginase* Antibody** Liver-type Arginase; Type I Arginase	WB, IHC-P	Mouse, Rat
Liver Arginase Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 35 kDa, targeting to Liver Arginase. It can be used for WB,IHC-P assays with tag free, in the background of Mouse, Rat.

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Arginase

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