Search Result

Targets Recommended:	COX

Results for "Asa cox Inhibitors" in MCE Product Catalog:

By Targets:	COX (170) Acyltransferase (2) ADC Cytotoxin (1) AMPK (1) Amyloid-β (1) Antibiotic (3) Apoptosis (23) Autophagy (18) Bacterial (10) Bcl-2 Family (1) Bcr-Abl (1) Calcium Channel (3) CaMK (1) Casein Kinase (1) Chloride Channel (1) CMV (1) Cytochrome P450 (2) Drug Metabolite (2) DYRK (2) Endogenous Metabolite (14) Ephrin Receptor (1) ERK (1) Estrogen Receptor/ERR (1) FAAH (1) Factor Xa (1) Ferroptosis (2) GLUT (1) HDAC (1) Histone Acetyltransferase (1) HIV (1) HSV (1) IGF-1R (1) Influenza Virus (5) Interleukin Related (3) Leukotriene Receptor (1) Lipoxygenase (10) mAChR (1) Melatonin Receptor (2) Microtubule/Tubulin (1) Mitophagy (5) MMP (2) NF-κB (19) NO Synthase (12) Notch (1) p38 MAPK (2) PAK (1) Parasite (1) PGE synthase (5) Phosphatase (1) Phospholipase (1) PI3K (1) PKA (1) PKC (1) Potassium Channel (2) PPAR (3) Prostaglandin Receptor (4) PTEN (1) Reactive Oxygen Species (7) Reverse Transcriptase (1) SARS-CoV (1) Sodium Channel (2) STING (1) Thrombin (1) TNF Receptor (3) Toll-like Receptor (TLR) (1) TRP Channel (2) Tyrosinase (1) VEGFR (1) Virus Protease (2)
By Research Areas:	Cancer (88) Cardiovascular Disease (13) Endocrinology (3) Infection (15) Inflammation/Immunology (158) Metabolic Disease (10) Neurological Disease (13)

By Targets:

COX (170)

Acyltransferase (2)

ADC Cytotoxin (1)

AMPK (1)

Amyloid-β (1)

Antibiotic (3)

Apoptosis (23)

Autophagy (18)

Bacterial (10)

Bcl-2 Family (1)

Bcr-Abl (1)

Calcium Channel (3)

CaMK (1)

Casein Kinase (1)

Chloride Channel (1)

CMV (1)

Cytochrome P450 (2)

Drug Metabolite (2)

DYRK (2)

Endogenous Metabolite (14)

Ephrin Receptor (1)

ERK (1)

Estrogen Receptor/ERR (1)

FAAH (1)

Factor Xa (1)

Ferroptosis (2)

GLUT (1)

HDAC (1)

Histone Acetyltransferase (1)

HIV (1)

HSV (1)

IGF-1R (1)

Influenza Virus (5)

Interleukin Related (3)

Leukotriene Receptor (1)

Lipoxygenase (10)

mAChR (1)

Melatonin Receptor (2)

Microtubule/Tubulin (1)

Mitophagy (5)

MMP (2)

NF-κB (19)

NO Synthase (12)

Notch (1)

p38 MAPK (2)

PAK (1)

Parasite (1)

PGE synthase (5)

Phosphatase (1)

Phospholipase (1)

PI3K (1)

PKA (1)

PKC (1)

Potassium Channel (2)

PPAR (3)

Prostaglandin Receptor (4)

PTEN (1)

Reactive Oxygen Species (7)

Reverse Transcriptase (1)

SARS-CoV (1)

Sodium Channel (2)

STING (1)

Thrombin (1)

TNF Receptor (3)

Toll-like Receptor (TLR) (1)

TRP Channel (2)

Tyrosinase (1)

VEGFR (1)

Virus Protease (2)

By Research Areas:

Cancer (88)

Cardiovascular Disease (13)

Endocrinology (3)

Infection (15)

Inflammation/Immunology (158)

Metabolic Disease (10)

Neurological Disease (13)

212

Inhibitors & Agonists

Screening Libraries

Natural
Products

Cat. No.	Product Name	Target	Research Areas

HY-10964

Vadimezan DMXAA; Asa-404	STING Interleukin Related Influenza Virus	Cancer Infection
Vadimezan (DMXAA; ASA-404), the tumor vascular disrupting agent (tumor-VDA), is a murine agonist of the stimulator of interferon genes (STING) and also a potent inducer of type I IFNs and other cytokines. Vadimezan has anti-influenza virus H1N1-PR8 activities.

HY-14654

Aspirin Acetylsalicylic Acid; Asa	COX Autophagy Mitophagy Virus Protease	Inflammation/Immunology Cancer
Aspirin is a non-selective and irreversible inhibitor of *COX-1* and *COX-2* with IC₅₀s of 5 and 210 μg/mL.

HY-U00275

COX-2-IN-1
COX Inflammation/Immunology

COX-2-IN-1 is potent and slective COX-2 inhibitor with an IC₅₀ of 3.9 μM.

COX-2-IN-1	COX	Inflammation/Immunology
COX-2-IN-1 is potent and slective *COX-2* inhibitor with an IC₅₀ of 3.9 μM.

HY-101655

COX-2-IN-2	COX	Inflammation/Immunology
COX-2-IN-2 is a selective and inducible *COX2* inhibitor with an IC₅₀ of 0.24 μM. COX-2-IN-1 is an anti-inflammatory compound with anti-inflammatory and analgesic activities.

HY-14445

FK 3311
cox-2 Inhibitor V
COX Inflammation/Immunology

FK 3311 (COX-2 Inhibitor V) is a selective inhibitor of COX-2 with antiinflammatory agent.

FK 3311 cox-2 Inhibitor V	COX	Inflammation/Immunology
FK 3311 (COX-2 Inhibitor V) is a selective inhibitor of *COX-2* with antiinflammatory agent.

HY-U00347

COX/5-LO-IN-1 Atreleuton analog	COX Lipoxygenase	Inflammation/Immunology
COX/5-LO-IN-1 (Atreleuton analog) is an inhibitor of cylooxygenase and 5-lipoxygenase (5-LO), used for the research of inflammatory and allergic disease states.

HY-136592

1-Hydroxy-ibuprofen	COX	Cancer Inflammation/Immunology
1-Hydroxy Ibuprofen is a metabolite of Ibuprofen in P. australis. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1* and COX-2 with IC₅₀s* of 13 μM and 370 μM, respectively.

HY-U00439

Protein kinase inhibitors 1
DYRK Cancer

Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC₅₀ of 74 nM and K_d of 9.5 nM.
HY-I0447

4-Aminosalicylic acid
Bacterial Antibiotic Infection Inflammation/Immunology

4-Aminosalicylic acid (ASA) is an orally active antibiotic and has the potential to treat tuberculosis.

*Protein kinase inhibitors* 1**	DYRK	Cancer
Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC₅₀ of 74 nM and K_d of 9.5 nM.

4-Aminosalicylic acid	Bacterial Antibiotic	Infection Inflammation/Immunology
4-Aminosalicylic acid (ASA) is an orally active antibiotic and has the potential to treat tuberculosis.

HY-14397

Indomethacin Indometacin	COX Bacterial Autophagy Antibiotic	Inflammation/Immunology Cancer
Indomethacin (Indometacin) is a potent and nonselective inhibitor of *COX1* and *COX2, with IC₅₀s of 18 nM and 26 nM for human COX-1 and COX*-2, respectively, in CHO cells.

HY-B0808

Oxaprozin Oxaprozinum; Wy21743	COX NF-κB	Inflammation/Immunology Cancer
Oxaprozin is an inhibitor of both *COX-1* and *COX-2* with IC₅₀s of 2.2 μM and 36 μM for human platelet COX-1 and IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-κB.

HY-B0367

Lornoxicam Chlortenoxicam; Ro 13-9297; TS110	COX Endogenous Metabolite	Inflammation/Immunology
Lornoxicam, a COX-1 and COX-2 inhibitor, is a new nonsteroidal anti-inflammatory drug (NSAID).

HY-15762

Valdecoxib SC 65872	COX	Inflammation/Immunology
Valdecoxib is a highly potent and selective inhibitor of *COX-2, with IC₅₀s of 5 nM and 140 μM for COX-2 and COX*-1, respeceively. Valdecoxib can be used in the research of arthritis and pain.

HY-B0580

Ketorolac RS37619	COX	Inflammation/Immunology
Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective *COX* inhibitor, with IC₅₀s of 20 nM for COX-1 and 120 nM for COX-2.

HY-N0356

(-)-Catechin gallate (-)-Catechin 3-gallate; (-)-Catechin 3-O-gallate	COX	Cancer
(-)-Catechin gallate is a minor constituent in green tea catechins. (-)-Catechin gallate inhibits the activity of *COX-1* and *COX-2* enzymes.

HY-B0008

Sulindac MK-231	COX Autophagy	Inflammation/Immunology Cancer
Sulindac (MK-231) is a non-steroidal antiinflammatory agent, acts as a *COX-2* inhibitor, and inhibits overexpression of COX-2.

HY-B0261

Meloxicam	COX Autophagy Apoptosis	Inflammation/Immunology Cancer
Meloxicam is a non-steroidal antiinflammatory agent, inhibits *COX* activity, with IC₅₀s of 0.49 µM and 36.6 µM for COX-2 and COX-1, respectively.

HY-N0481

Roburic acid	COX	Inflammation/Immunology
Roburic acid, a tetracyclic triterpenoid found in Gentiana macrophylla, acts as an inhibitor of *COX, with IC₅₀s of 5 and 9 μM for COX-1 and COX*-2, respectively.

HY-15027

5-Aminosalicylic Acid Mesalamine; 5-Asa; Mesalazine	PPAR PAK NF-κB Endogenous Metabolite	Inflammation/Immunology Cancer
5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.

HY-17372

Rofecoxib MK 966	COX	Inflammation/Immunology Cancer
Rofecoxib is a potent, specific and orally active *COX-2* inhibitor, with IC₅₀s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC₅₀ > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells).

HY-B2137

S-(+)-Ketoprofen
(S)-Ketoprofen; Dexketoprofen
COX Inflammation/Immunology

S-(+)-Ketoprofen is a potent inhibitor of both COX-1 and COX-2 with IC₅₀s of 1.9 and 27 nM, respectively.

S-(+)-Ketoprofen (S)-Ketoprofen; Dexketoprofen	COX	Inflammation/Immunology
S-(+)-Ketoprofen is a potent inhibitor of both *COX-1* and *COX-2* with IC₅₀s of 1.9 and 27 nM, respectively.

HY-B0138

Ketorolac tromethamine salt Ketorolac Tromethamine; Ketorolac tris salt; RS37619 tromethamine salt	COX	Inflammation/Immunology
Ketorolac tromethamine salt (RS37619 tromethamine salt) is a non-steroidal anti-inflammatory agent, acting as a nonselective *COX* inhibitor, with IC₅₀s of 20 nM for COX-1 and 120 nM for COX-2.

HY-19212

S-2474	COX Lipoxygenase	Inflammation/Immunology
S-2474 is an inhibitor of *COX-2* and 5-lipoxygenase (5-LO), with IC₅₀s of 11 nM and 27 μM for COX-2 and COX-1 in human intact cells, and used as a nonsteroidal anti-inflammatory drug.

HY-15036

Diclofenac	COX Apoptosis	Inflammation/Immunology
Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a *COX* inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.

HY-15038

Diclofenac potassium	COX Apoptosis	Inflammation/Immunology
Diclofenac potassium is a potent and nonselective anti-inflammatory agent, acts as a *COX* inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac potassium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.

HY-15321

Etoricoxib MK-0663; L-791456	COX	Inflammation/Immunology Cancer
Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active *COX-2* inhibitor, with IC₅₀s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.

HY-B0253

Piroxicam CP-16171	COX	Inflammation/Immunology Cancer
Piroxicam (CP-16171) is a non-steroidal anti-inflammatory drugs, acts as a *COX* inhibitor, with IC₅₀s of 47, 25 μM for human monocyte COX-1 and COX-2, respectively.

HY-78131

Ibuprofen
(±)-Ibuprofen
COX Inflammation/Immunology Cancer

Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC₅₀s of 13 μM and 370 μM, respectively.
HY-15030A

Naproxen sodium
Autophagy COX Inflammation/Immunology Cancer

Naproxen sodium is a COX-1 and COX-2 inhibitor with IC₅₀s of 8.72 and 5.15 μM, respectively in cell assay.
HY-15030

Naproxen
(S)-Naproxen
COX Autophagy Inflammation/Immunology Cancer

Naproxen is a COX-1 and COX-2 inhibitor with IC₅₀s of 8.72 and 5.15 μM, respectively in cell assay.

Ibuprofen (±)-Ibuprofen	COX	Inflammation/Immunology Cancer
Ibuprofen is an anti-inflammatory inhibitor targeting *COX-1* and *COX-2* with IC₅₀s of 13 μM and 370 μM, respectively.

Naproxen sodium	Autophagy COX	Inflammation/Immunology Cancer
Naproxen sodium is a *COX-1* and *COX-2* inhibitor with IC₅₀s of 8.72 and 5.15 μM, respectively in cell assay.

Naproxen (S)-Naproxen	COX Autophagy	Inflammation/Immunology Cancer
Naproxen is a *COX-1* and *COX-2* inhibitor with IC₅₀s of 8.72 and 5.15 μM, respectively in cell assay.

HY-15036A

Diclofenac diethylamine	COX Apoptosis	Inflammation/Immunology
Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a *COX* inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac diethylamine induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.

HY-15037

Diclofenac Sodium GP 45840	COX Apoptosis	Inflammation/Immunology
Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a *COX* inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.

HY-17479A

Amfenac Sodium Hydrate
COX Inflammation/Immunology

Amfenac Sodium Hydrate is a COX-2 inhibitor.

Amfenac Sodium Hydrate	COX	Inflammation/Immunology
Amfenac Sodium Hydrate is a *COX-2* inhibitor.

HY-14397S

Indomethacin-D4 Indometacin-D4	COX Autophagy	Inflammation/Immunology
Indomethacin-D4 (Indometacin-D4) is a deuterium labeled Indomethacin. Indomethacin is a potent and nonselective inhibitor of *COX1* and *COX2, with IC₅₀s of 18 nM and 26 nM for human COX-1 and COX*-2, respectively, in CHO cells.

HY-B0227

Ketoprofen RP-19583	COX Apoptosis	Inflammation/Immunology
Ketoprofen (RP-19583) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of *COX, with IC₅₀s of 2 nM and 26 nM for COX-1 and COX*-2 in human blood monocytes, respectively.

HY-B0580S

Ketorolac D5	COX	Inflammation/Immunology
Ketorolac D5 is a deuterium labeled Ketorolac. Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective *COX* inhibitor, with IC₅₀s of 20 nM for COX-1 and 120 nM for COX-2.

HY-N0396

Harpagoside	COX NO Synthase	Inflammation/Immunology
Harpagoside is isolated from Harpagophytum procumbens (Hp). Harpagoside has inhibitory effects on *COX-1* and *COX-2* activity and inhibits NO production.

HY-15123

(S)-Flurbiprofen Esflurbiprofen	COX PGE synthase	Inflammation/Immunology
(S)-Flurbiprofen is an active enantiomer of Flurbiprofen, with IC₅₀ values of 0.48 μM and 0.47 μM for *COX-1* and *COX-2*, respectively.

HY-B0335

Tolfenamic Acid GEA 6414	COX	Inflammation/Immunology Cancer
Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits *COX-2, with an IC₅₀* of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.

HY-14670

Firocoxib ML 1785713	COX	Inflammation/Immunology
Firocoxib (ML 1785713) is a potent, selective and orally active *COX-2* inhibitor with an IC₅₀ of 0.13 μM. Firocoxib shows 58-fold more selective for *COX-2* than COX-1 (IC₅₀ of 7.5 μM). Firocoxib has anti-inflammatory effects.

HY-B1227

Carprofen	COX FAAH Autophagy	Inflammation/Immunology
Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target *FAAH/COX* inhibitor, with IC₅₀s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively.

HY-78131S

Ibuprofen D3
(±)-Ibuprofen D3
COX Inflammation/Immunology

Ibuprofen D3 is a deuterium labeled Ibuprofen. Ibuprofen is a COX-1 and COX-2 inhibitor with IC₅₀s of 13 μM and 370 μM.
HY-17474

Parecoxib
SC 69124
COX Cancer Inflammation/Immunology

Parecoxib is a potent and selective COX-2 inhibitor.

Ibuprofen D3 (±)-Ibuprofen D3	COX	Inflammation/Immunology
Ibuprofen D3 is a deuterium labeled Ibuprofen. Ibuprofen is a COX-1 and COX-2 inhibitor with IC₅₀s of 13 μM and 370 μM.

Parecoxib SC 69124	COX	Cancer Inflammation/Immunology
Parecoxib is a potent and selective COX-2 inhibitor.

HY-B0261S

Meloxicam D4	COX Autophagy Apoptosis	Cancer Inflammation/Immunology
Meloxicam D4 is deuterium labeled Meloxicam. Meloxicam is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC₅₀s of 0.49 µM and 36.6 µM for COX-2 and COX-1, respectively.

HY-B1130

Isoxicam	COX	Inflammation/Immunology
Isoxicam is an orally active, long-acting, non-steroidal anti-inflammatory agent for the research of arthritis. Isoxicam is a nonselective inhibitor of *COX-1* and *COX-2*.

HY-100580

Asaraldehyde Asaronaldehyde; Asaraldehyde; 2,4,5-trimethoxy-Benzaldehyde	COX	Inflammation/Immunology
Asarylaldehyde is a natural *COX-2* inhibitor, which isolated from carrot (Daucus carota L.) seeds significantly inhibits cyclooxygenase II (COX-2) activity at IC₅₀ value 100 μg/mL.

HY-15321S

Etoricoxib D4 MK-0663 D4; L-791456 D4	COX	Others
Etoricoxib D4 (MK-0663 D4) is a deuterium labeled Etoricoxib. Etoricoxib is a non steroidal anti-inflammatory agent, acting as a selective and orally active *COX-2* inhibitor, with IC₅₀s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.

HY-105028

Tenidap CP-66248	COX	Inflammation/Immunology
Tenidap, a non-steroidal anti-inflammatory drug, is a selective *COX-1* inhibitor, with IC₅₀ values of 0.03 µM and 1.2 µM for COX-1 and COX-2, respectively. Tenidap has anti-inflammatory and antirheumatic properties. Tenidap is also a specific SLC26A3 inhibitor.

HY-N2266

Benzoylgomisin O	COX	Inflammation/Immunology
Benzoylgomisin O isolated from Schisandra rubriflora, has inhibitory activity against 15-LOX, *COX-1* and *COX-2* enzymes and anti-inflammatory activity.

HY-126121

2-Hydroxy Ibuprofen (±)-2-Hydroxy Ibuprofen	COX	Cancer Inflammation/Immunology
2-Hydroxy Ibuprofen is a metabolite of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC₅₀s of 13 μM and 370 μM, respectively.

HY-U00239

SC58451
COX Inflammation/Immunology

SC58451 is a potent and selective Cox-2 inhibitor.
HY-14398

Celecoxib
SC 58635
COX Inflammation/Immunology Cancer

Celecoxib is a selective COX-2 inhibitor with an IC₅₀ of 40 nM.

HY-131259

Ibuprofen Impurity F	COX	Inflammation/Immunology
Ibuprofen Impurity F is an Ibuprofen impurity. Ibuprofen is an anti-inflammatory inhibitor targeting *COX-1* and *COX-2* with IC₅₀s of 13 μM and 370 μM, respectively.

HY-N2599

Taraxerol acetate	COX Apoptosis	Cancer
Taraxerol acetate is a *COX-1* and *COX-2* inhibitor with IC₅₀ values of 116.3 μM and 94.7 μM, respectively. Taraxerol acetate the has the anticancer potential and induces cell apoptosis.

HY-131258

Ibuprofen impurity 1	COX	Inflammation/Immunology
Ibuprofen impurity 1 is an Ibuprofen impurity. Ibuprofen is an anti-inflammatory inhibitor targeting *COX-1* and *COX-2* with IC₅₀s of 13 μM and 370 μM, respectively.

HY-131260

Ibuprofen Impurity K	COX	Inflammation/Immunology
Ibuprofen Impurity K is an Ibuprofen impurity. Ibuprofen is an anti-inflammatory inhibitor targeting *COX-1* and *COX-2* with IC₅₀s of 13 μM and 370 μM, respectively.

HY-B0253S

Piroxicam D3 CP-16171 D3	COX	Cancer Inflammation/Immunology
Piroxicam D3 (CP-16171 D3) is deuterium labeled Piroxicam. Piroxicam is a non-steroidal anti-inflammatory drugs, acts as a COX inhibitor, with IC₅₀s of 47, 25 μM for human monocyte COX-1 and COX-2, respectively .

HY-17474A

Parecoxib Sodium
SC 69124A
COX Inflammation/Immunology Cancer

Parecoxib Sodium (SC 69124A) is a potent and selective COX-2 inhibitor.

HY-N0523

Gallic acid 3,4,5-Trihydroxybenzoic acid	COX Reactive Oxygen Species Apoptosis Ferroptosis Endogenous Metabolite	Cancer Metabolic Disease
Gallic acid is an antioxidant which can inhibit both *COX-2*.

HY-N0929

Hexahydrocurcumin	COX Reactive Oxygen Species	Cancer
Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active *COX-2* inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities.

HY-B0360

Rebamipide OPC12759; Proamipide	COX Prostaglandin Receptor	Cancer Inflammation/Immunology
Rebamipide (OPC12759) is a mucoprotective agent. Rebamipide induces *COX-2* expression, increases PGE2 levels, and enhances gastric mucosal defense in a COX-2-dependent manner.

HY-17009

Iguratimod T614	COX	Inflammation/Immunology
Iguratimod is an antirheumatic agent, acts as an inhibitor of *COX-2, with an IC₅₀* of 20 μM (7.7 μg/mL), but shows no effect on COX-1. Iguratimod also inhibits macrophage migration inhibitory factor (MIF) with an IC₅₀ of 6.81 μM.

HY-N0767

Isoorientin
Homoorientin
COX Cancer Inflammation/Immunology

Isoorientin is a potent inhibitor of COX-2 with an IC₅₀ value of 39 μM.

HY-111950

(-)-Ibuprofenamide (R)-Ibuprofenamide	Others	Inflammation/Immunology
(-)-Ibuprofenamide is an amide prodrug of Ibuprofen with anti-inflammatory activity. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC₅₀s of 13 μM and 370 μM, respectively.

HY-131005

Ehp inhibitor 2
Ephrin Receptor Cancer

Ehp inhibitor 2 is a Eph family tyrosine kinase inhibitor.

HY-W012126

2,6-Dichlorodiphenylamine 2,6-Dichloro-N-phenylaniline	Bacterial	Cancer Infection
2,6-Dichlorodiphenylamine is an analogue of Diclofenac Sodium (HY-15037) and has anti-Candida albicans activity. Diclofenac Sodium is a potent and nonselective anti-inflammatory agent, acts as a COX* inhibitor,* with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells.

HY-78131A

(S)-(+)-Ibuprofen (S)-Ibuprofen	COX	Inflammation/Immunology
(S)-(+)-Ibuprofen is the S(+)-enantiomer of Ibuprofen that inhibits *COX-1* and *COX-2* activity with IC₅₀s of 2.1 μM and 1.6 μM. (S)-(+)-Ibuprofen has analgesic, antiinflammatory and antipyretic effects.

HY-59105

SC-560
COX Cancer

SC-560 is a potent and selective COX-1 inhibitor with an IC₅₀ of 9 nM.
HY-U00083

Flosulide
ZK 38997; CGP 28238
COX Inflammation/Immunology

Flosulide is a potent and selective COX-2 inhibitor, used for the treatment for inflammatory diseases.

HY-19675

Naproxen etemesil LT-NS 001; MX 1094	COX	Inflammation/Immunology
Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a *COX-1* and *COX-2* inhibitor with IC₅₀s of 8.72 and 5.15 μM, respectively in cell assay.

HY-B0363

Nimesulide R805	COX	Inflammation/Immunology
Nimesulide is a selective *COX-2* inhibitor, with IC₅₀s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC₅₀ >100 μM). Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties.

HY-B1279

Metamizole sodium hydrate
COX Inflammation/Immunology

Metamizole sodium hydrate is a potent analgesic drug that has been demonstrated to inhibit cyclooxygenase (COX).
HY-17357S

Nepafenac D5
AHR-9434 D5; AL-6515 D5
COX Others

Nepafenac D5 is the deuterium labeled Nepafenac, which is a selective COX-2 inhibitor.
HY-N0355

(+)-Catechin hydrate
COX Cancer

(+)-Catechin hydrate inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 1.4 μM.

HY-103387

DuP-697	COX Apoptosis	Cancer Inflammation/Immunology
DuP-697 is a member of the vicinal diaryl heterocycles and a potent, irreversible, selective and orally active *COX-2* inhibitor (IC₅₀ of 10 nM and 800 nM for human *COX-2* and *COX-1, respectively). DuP-697 exerts antiproliferative (IC₅₀* of 42.8 nM), antiangiogenic and apoptotic effects on HT29 colorectal cancer cells. DuP-697 inhibits prostaglandin synthesis and has anti-inflammatory, anticancer and antipyretic effects.

HY-13913

NS-398	COX	Inflammation/Immunology Cancer
NS-398 is a non-steroidal an-inflammatory agent with analgesic and antipyretic effects, and selectively inhibits prostaglandin G/H synthase 2/cyclooxygenase 2 (COX-2) activity, with an IC₅₀ of 3.8 μM, and has no effect on COX-1 at 100 μM.

HY-17357

Nepafenac
AHR 9434; AL 6515
COX Inflammation/Immunology

Nepafenac(AHR 9434; AL 6515; Nevanac) is a selective COX-2 inhibitor; is prodrug of Amfenac.
HY-U00146

FR-188582
COX Inflammation/Immunology

FR-188582 is a highly selective inhibitor of cyclooxygenase (COX)-2, with an IC₅₀ value of 17 nM.
HY-B0476

Phenacetin
Acetophenetidin
COX Inflammation/Immunology

Phenacetin is a non-opioid analgesic without anti-inflammatory properties, inhibits COX-3 activity.
HY-112731

TFAP
N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide
COX Endogenous Metabolite Metabolic Disease

TFAP is a selective cyclooxygenase-1 (COX-1) inhibitor, with an IC₅₀ of 0.8 μM.

HY-N0898

Catechin (+)-Catechin; Cianidanol; Catechuic acid	COX Apoptosis Influenza Virus Endogenous Metabolite	Cancer
Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 1.4 μM.

HY-N0147

Rutaecarpine
Rutecarpine
COX Inflammation/Immunology Cancer

Rutaecarpine, an alkaloid of Evodia rutaecarpa, is an inhibitor of COX-2 with an IC₅₀ value of 0.28 μM.

HY-B0360S

Rebamipide D4 OPC12759 D4; Proamipide D4	COX Prostaglandin Receptor	Cancer Inflammation/Immunology
Rebamipide D4 (OPC12759 D4) is deuterium labeled Rebamipide. Rebamipide is a mucoprotective agent. Rebamipide induces *COX-2* expression, increases PGE2 levels, and enhances gastric mucosal defense in a COX-2-dependent manner.

HY-N6891

Hamaudol	COX	Inflammation/Immunology
Hamaudol is a chromone isolated from Saposhnikovia divaricata. Hamaudol shows significant inhibitory activity on cyclooxygenase (COX)-1 and *COX-2* activities with IC₅₀ values of 0.30, 0.57 mM, respectively, and has potent analgesia and anti-inflammary effects.

HY-N0256

Hederagenin
Others Cancer

Hederagenin is a triterpenoid saponin. It can inhibit LPS-stimulated expression of iNOS, COX-2, and NF-κB.

HY-N0346A

(E)-Ethyl p-methoxycinnamate	COX	Cancer Infection Inflammation/Immunology
(E)-Ethyl p-methoxycinnamate is a natural product found in Kaempferia galangal with anti-inflammatory, anti-neoplastic and anti-microbial effects. (E)-Ethyl p-methoxycinnamate inhibits *COX-1* and *COX-2* in vitro with IC₅₀s of 1.12 and 0.83 μM, respectively.

HY-U00197

Tilmacoxib JTE522; JTP19605; RWJ57504	COX	Inflammation/Immunology
Tilmacoxib (JTE522) is a highly selective, time-dependent and irreversible human *COX-2* inhibitor with an IC₅₀ of 85 nM in an enzyme assay.

HY-N0002

(-)-Epicatechin gallate Epicatechin gallate; ECG; (-)-Epicatechin 3-O-gallate	COX Autophagy Virus Protease	Cancer
(-)-Epicatechin gallate (Epicatechin gallate) inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 7.5 μM.

HY-N2176

S-(+)-Marmesin
(+)-Marmesin; (S)-Marmesin
COX Lipoxygenase Others

S-(+)-Marmesin is a natural coumarin, exhibiting COX-2/5-LOX dual inhibitory activity.

HY-B0363S

Nimesulide D5	COX	Inflammation/Immunology
Nimesulide D5 is a deuterium labeled Nimesulide. Nimesulide is a selective *COX-2* inhibitor, with IC₅₀s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC₅₀ >100 μM). Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties.

HY-U00022

RWJ 63556
COX Lipoxygenase Inflammation/Immunology

RWJ 63556 is an orally active COX-2 selective/5-lipoxygenase inhibitor, with anti-inflammatory activities.

HY-108259

HQL-79	PGE synthase	Inflammation/Immunology
HQL-79 is a potent, selective and orally active human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, highly selectively inhibits the synthesis of PGD₂, and acts as an anti-allergic agent, with a K_d of 0.8 μM and an IC₅₀ of 6 μM. Shows no obvious effect on COX-1, COX-2, m-PGES, or L-PGDS.

HY-N1067

Xanthohumol	COX Acyltransferase Apoptosis HSV CMV Influenza Virus	Cancer Infection
Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), *COX-1* and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2 and cytomegalovirus (CMV).

HY-78131AS

(S)-(+)-Ibuprofen D3 (S)-Ibuprofen D3	COX	Inflammation/Immunology
(S)-(+)-Ibuprofen D3 ((S)-Ibuprofen D3) is a deuterium labeled (S)-(+)-Ibuprofen. (S)-(+)-Ibuprofen is the S(+)-enantiomer of Ibuprofen that inhibits *COX-1* and *COX-2* activity with IC₅₀s of 2.1 μM and 1.6 μM. (S)-(+)-Ibuprofen has analgesic, antiinflammatory and antipyretic effects.

HY-N0149

Salicin
D-(−)-Salicin; Salicoside
COX Cancer Inflammation/Immunology

Salicin is a natural COX inhibitor.

HY-129113

α-Chaconine	COX	Inflammation/Immunology
α-Chaconine, isolated from a Solanum tuberosum L. cv Jayoung, inhibits the expressions of *COX-2, IL-1β, IL-6, and TNF-α* at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and *COX-2* at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects.

HY-121879

SHP836
Phosphatase Cancer

SHP836 is a SHP2 allosteric inhibitor, with an IC₅₀ of 12 μM for the full length SHP2.
HY-122591

PTUPB
COX Cancer Metabolic Disease

PTUPB is a potent and dual sEH and COX-2 enzymes inhibitor with IC₅₀ of 0.9 nM and 1.26 μM, respectively.

HY-B0580B

(R)-Ketorolac (+)-Ketorolac	Others	Neurological Disease
(R)-Ketorolac is the R-enantiomer of Ketorolac, shows potent analgesic activity, reduces ulcerogenic potential. (R)-Ketorolac is inactive on COX.

HY-B0167A

Sodium Salicylate Salicylic acid sodium salt; 2-Hydroxybenzoic acid sodium salt	COX Autophagy Apoptosis	Inflammation/Immunology Cancer
Sodium Salicylate (Salicylic acid sodium salt) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation.

HY-B0580A

(S)-Ketorolac
(-)-Ketorolac
COX Inflammation/Immunology

(S)-Ketorolac is a nonsteroidal anti-inflammatory agent. (S)-ketorolac exhibits potent COX1 and COX2 enzyme inhibition.

HY-114200

Imrecoxib BAP-909	COX	Inflammation/Immunology
Imrecoxib (BAP-909) is a novel and selective cyclooxygenase 2 (COX-2) inhibitor with an IC₅₀ value of 18 nM, it also inhibits COX1- activity with an IC₅₀ value of 115 nM. Imrecoxib (BAP-909) has anti-inflammatory effect.

HY-N0074

Byakangelicol	COX	Inflammation/Immunology
Byakangelicol, isolated from Angelica dahurica, inhibits interleukin-1beta (IL-1beta) -induced prostaglandin E2 (PGE2) release in A549 cells mediated by suppression of cyclooxygenase-2 (COX-2) expression and the activity of COX-2 enzyme. Byakangelicol has therapeutic potential as an anti-inflammatory drug on airway inflammation.

HY-B0559

Nabumetone BRL14777	COX	Inflammation/Immunology Cancer
Nabumetone is an orally active non-acidic anti-inflammatory agent, acts as a potent and selective *COX-2* inhibitor, and is the prodrug of the active metabolite 6MNA.

HY-B1026

Adelmidrol	NF-κB COX PPAR	Inflammation/Immunology
Adelmidrol exerts important anti-inflammatory effects that are partly dependent on PPARγ. Adelmidrol reduces NF-κB translocation, and *COX-2* expression.

HY-N5015

Rosmanol	Others	Inflammation/Immunology Cancer
Rosmanol could inhibit the oxidation of low density lipoprotein (LPL) and significantly inhibit lipopolysaccharide induced iNOS and COX-2 expression, with anti-inflammatory effect.

HY-B0167

Salicylic acid 2-Hydroxybenzoic acid	COX Autophagy Mitophagy Apoptosis Endogenous Metabolite	Inflammation/Immunology Cancer
Salicylic acid (2-Hydroxybenzoic acid) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation.

HY-U00175

Pamicogrel
KBT3022
COX Cardiovascular Disease

Pamicogrel (KBT3022) is a cyclooxygenase (COX) inhibitor.

HY-14617

Paradol [6]-Gingerone; [6]-Paradol	COX	Cancer
Paradol is a pungent phenolic substance found in ginger and other Zingiberaceae plants. Paradol is an effective inhibitor of tumor promotion in mouse skin carcinogenesis, binds to cyclooxygenase (COX)-2 active site.

HY-N7067

Revaprazan hydrochloride	Bacterial COX	Infection
Revaprazan hydrochloride is a novel acid pump antagonist (APA). Revaprazan hydrochloride reduces *COX-2* expression and has significant anti-inflammatory actions activities in H. pylori infection.

HY-N1380

Guaiacol 2-Methoxyphenol	COX NF-κB Endogenous Metabolite	Inflammation/Immunology
Guaiacol, a phenolic compound isolated from Guaiac resin, inhibits LPS-stimulated *COX-2* expression and NF-κB activation. Anti-inflammatory activity.

HY-N0635

Prim-O-glucosylcimifugin	NO Synthase COX	Inflammation/Immunology
Prim-O-glucosylcimifugin exerts anti-inflammatory effects through the inhibition of iNOS and *COX-2* expression by through regulating JAK2/STAT3 signaling.

HY-119304

GW-406381	COX	Inflammation/Immunology Neurological Disease
GW406381, a highly selective cyclooxygenase-2 (COX-2) inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury.

HY-12383

Pelubiprofen	COX	Inflammation/Immunology Neurological Disease
Pelubiprofen, an orally active and non-steroidal anti-inflammatory drug, is a member of the 2-arylpropionic acid family and has relatively selective effects on *COX-2* activity. Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway, and has significant anti-inflammatory and analgesic effects.

HY-U00129

SC57666
COX Inflammation/Immunology

SC57666 is a selective COX2 inhibitor with an IC₅₀ of 26 nM.
HY-B0619

Zaltoprofen
CN100
COX Inflammation/Immunology

Zaltoprofen(CN100) is an inhibitor of COX for treatment of arthritis.

HY-19373

RWJ-445167 3DP-10017	Thrombin Factor Xa	Cardiovascular Disease
RWJ-445167 (3DP-10017) is a dual inhibitor of thrombin and factor Xa with K_i of 4.0 nM and 230 nM, respectively, exhibiting potent antithrombotic activity.

HY-16787

ICA-121431	Sodium Channel	Cardiovascular Disease
ICA-121431 is a nanomolar potent and broad-spectrum voltage-gated sodium channel (Na_v) blocker, shows equipotent selectivity for human Na_v1.1 and Na_v1.3 subtypes with IC₅₀ values of 13 nM and 23 nM, respectively. ICA-121431 shows less potent inhibition of Na_v1.2 (IC₅₀=240 nM) and 1,000 fold selectivity against Na_v1.4, Na_v1.6, and the TTX-resistant human Na_v1.5 and Na_v1.8 channels (IC₅₀s >10 µM).

HY-N6968

α-Humulene Humulene; α-Caryophyllene	NO Synthase COX	Inflammation/Immunology
α-Humulene is a main constituent of Tanacetum vulgare L. (Asteraceae) essential oil with anti-inflammation (IC₅₀=15±2 µg/mL). α-Humulene inhibits *COX-2* and iNOS expression.

HY-N0493

Pectolinarigenin	COX Lipoxygenase	Inflammation/Immunology
Pectolinarigenin, isolated from Cirsium chanroenicum, is a dual inhibitor of *COX-2/5-LOX*. Anti-inflammatory activity. Pectolinarigenin has potent inhibitory activities on melanogenesis.

HY-N2410

N-trans-Feruloyltyramine N-feruloyltyramine; Moupinamide	COX	Inflammation/Immunology
N-trans-Feruloyltyramine (N-feruloyltyramine), an alkaloid from Piper nigru, is an inhibitor of *COX1* and *COX2*, with potential antioxidant properties. N-trans-Feruloyltyramine possesses anti-inflammatory activity.

HY-N2429

Sphondin	COX	Inflammation/Immunology
Sphondin, isolated from Heracleum laciniatum, possesses an inhibitory effect on IL-1β-induced increase in the level of *COX-2* protein and PGE₂ release in A549 cells.

HY-118139

Desmethyl Celecoxib	COX	Inflammation/Immunology
Desmethyl Celecoxib (compound 3b) is a selective cyclooxygenase-2 (COX-2) inhibitor (IC₅₀=32 nM) with anti-inflammatory activities. Desmethyl Celecoxib is an analog of Celecoxib and with the optimal yield of 75%.

HY-B2158

Chlorotrianisene	Estrogen Receptor/ERR COX	Endocrinology Cardiovascular Disease
Chlorotrianisene is a long-acting non-steroidal estrogen and an orally active estrogen receptor modulator. Chlorotrianisene exhibits antiestrogenic activity. Chlorotrianisene potently inhibits the enzyme *COX-1* and inhibits platelet aggregation in whole blood.

HY-N0001

(-)-Epicatechin (-)-Epicatechol; Epicatechin; epi-Catechin	COX Ferroptosis Endogenous Metabolite	Cancer Inflammation/Immunology
(-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.

HY-N3848

Ermanin	Bacterial COX NO Synthase Influenza Virus	Infection Inflammation/Immunology Cardiovascular Disease
Ermanin is a flavonoid isolated from Tanacetum microphyllum. Ermanin potently inhibits iNOS, *COX-2* activities, and inhibits platelet aggregation. Ermanin has anti-inflammatory, anti-tuberculous and anti-viral/bacterial properties.

HY-135325

4-Hydroxyacetophenone oxime	Others	Inflammation/Immunology
4-Hydroxyacetophenone oxime is an impurity of Acetaminophen (Paracetamol). Acetaminophen is a potent cyclooxygenase-2 (COX-2) and hepatic N-acetyltransferase 2 (NAT2) inhibitor, and used antipyretic and analgesic drug.

HY-W015007

Metyrosine	COX	Cardiovascular Disease
Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity. Metyrosine is a very effective agent for blood pressure control.

HY-N2434

[10]-Shogaol	COX	Cancer
[10]-Shogaol is an antioxidant from Zingiber officinale for human skin cell growth and a migration enhancer. [10]-Shogaol inhibits COX-2 with an IC₅₀ of 7.5 μM and has antiproliferation activity.

HY-126114

Lupeol acetate	Others	Inflammation/Immunology
Lupeol acetate, a derivative of Lupeol, suppresses the progression of rheumatoid arthritis (RA) by inhibiting the activation of macrophages and osteoclastogenesis through downregulations of TNF-α, IL-1β, MCP-1, COX-2, VEGF and granzyme B.

HY-N0589

Dehydrodiisoeugenol	NF-κB COX Bacterial	Infection Inflammation/Immunology
Dehydrodiisoeugenol is isolated from Myristica fragrans Houtt, shows anti-inflammatory and anti-bacterial actions. Dehydrodiisoeugenol inhibits LPS- stimulated NF-κB activation and cyclooxygenase (COX)-2 gene expression in murine macrophages.

HY-N0447

8-Gingerol	TRP Channel	Infection Inflammation/Immunology Cancer
8-Gingerol, found in the rhizomes of ginger (Z. officinale) with oral bioavailability, activates TRPV1, with an EC₅₀ of 5.0 µM. 8-Gingerol inhibits COX-2, and inhibits the growth of H. pylori in vitro.

HY-N0898A

(-)-Catechin (-)-Cianidanol; (-)-Catechuic acid	COX	Cancer
(-)-Catechin, isolated from green tea, is an isomer of Catechin having a trans 2S,3R configuration at the chiral center. Catechin inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 1.4 μM.

HY-66004

4-Acetamidophenyl acetate	Others	Inflammation/Immunology
4-Acetamidophenyl acetate is an impurity of Acetaminophen (paracetamol). Acetaminophen, an analgesic drug, is a selective COX-2 inhibitor (IC₅₀=25.8 μM), and is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.

HY-N0698

Crocin II	NO Synthase COX	Cancer Inflammation/Immunology Neurological Disease
Crocin II is isolated from the fruit of Gardenia jasminoides with antioxidant, anticancer, and antidepressant activity. Crocin II inhibits NO production with an IC₅₀ value of 31.1 μM. Crocin II suppresses the expressions of protein and m-RNA of iNOS and *COX-2*.

HY-B0760

Fenofibric acid FNF acid	PPAR COX	Metabolic Disease
Fenofibric acid, an active metabolite of fenofibrate, is a PPAR activitor, with EC₅₀s of 22.4 µM, 1.47 µM, and 1.06 µM for PPARα, PPARγ and PPARδ, respectively; Fenofibric acid also inhibits *COX-2* enzyme activity, with an IC₅₀ of 48 nM.

HY-U00439A

*Protein kinase inhibitors* 1 hydrochloride** (E)-5-((2-Oxo-6'-(piperazin-1-yl)-1,2-dihydro-[3,3'-bipyridin]-5-yl)methylene)thiazolidine-2,4-dione hydrochloride	DYRK	Cancer
Protein kinase inhibitors 1 hydrochloride is a potent HIPK2 inhibitor, with IC₅₀s of 136 and 74 nM for HIPK1 and HIPK2, and a K_d of 9.5 nM for HIPK2.

HY-B1489

Tolmetin sodium dihydrate
COX Inflammation/Immunology

Tolmetin sodium dihydrate is a non-steroidal antiinflammatory agent, and acts as a non-selective COX inhibitor.

HY-N0710

alpha-Cyperone α-Cyperone; (+)-α-Cyperone	Endogenous Metabolite	Inflammation/Immunology
alpha-Cyperone (α-Cyperone) is associated with the down-regulation of COX-2, IL-6, Nck-2, Cdc42 and Rac1, resulting in reduction of inflammation, which would be highly beneficial for treatment of inflammatory diseases such as AD.

HY-119447

Mavacoxib	COX	Inflammation/Immunology
Mavacoxib is a selective, oral long-acting cyclooxygenase-2 (COX-2) inhibitor and a long-acting non-steroidal anti-inflammatory drug (NSAID). Mavacoxib is used to treat pain and inflammation associated with degenerative joint disease in dogs.

HY-B0167S

Salicylic acid-D6 2-Hydroxybenzoic acid-D6	COX Autophagy Mitophagy Apoptosis	Cancer Inflammation/Immunology
Salicylic acid-D6 (2-Hydroxybenzoic acid-D6) is a deuterium labeled Salicylic acid. Salicylic acid inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation.

HY-N2454

β-Elemonic acid	Apoptosis Reactive Oxygen Species COX	Cancer Inflammation/Immunology
β-Elemonic acid is a triterpene isolated from Boswellia papyrifera. β-Elemonic acid induces cell apoptosis, reactive oxygen species (ROS) and *COX-2* expression and inhibits prolyl endopeptidase. β-Elemonic acid exhibits anticancer and anti-inflammatory effects.

HY-W012037

8-Hydroxyquinoline hemisulfate 8-Quinolinol hemisulfate	Bacterial Antibiotic	Infection
8-Hydroxyquinoline hemisulfate (8-Quinolinol hemisulfate) is a monoprotic bidentate chelating agent, exhibits antiseptic, disinfectant, and pesticide properties, functioning as a transcription inhibitor.

HY-N1996

Chebulagic acid	COX Lipoxygenase Influenza Virus	Infection Inflammation/Immunology
Chebulagic acid is a COX-LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz, on angiogenesis.

HY-B0386

Flunixin meglumine
COX Inflammation/Immunology

Flunixin Meglumine is a potent inhibitor of COX used as analgesic agent with anti-inflammatory and antipyretic activity.

HY-N0722

Neochlorogenic acid trans-5-O-Caffeoylquinic acid	NF-κB Interleukin Related TNF Receptor COX	Inflammation/Immunology Cancer
Neochlorogenic acid is a natural polyphenolic compound found in dried fruits and other plants. Neochlorogenic acid inhibits the production of TNF-α and IL-1β. Neochlorogenic acid suppresses iNOS and COX-2 protein expression. Neochlorogenic acid also inhibits phosphorylated NF-κB p65 and p38 MAPK activation.

HY-66005

Acetaminophen Paracetamol; 4-Acetamidophenol; 4'-Hydroxyacetanilide	COX Histone Acetyltransferase Endogenous Metabolite	Inflammation/Immunology
Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀ of 25.8 μM; is a widely used antipyretic and analgesic agent. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.

HY-N0607

Ginsenoside Ro PolysciAsaponin P3; Chikusetsusaponin 5; Chikusetsusaponin V	Calcium Channel Prostaglandin Receptor	Cardiovascular Disease Endocrinology
Ginsenoside Ro (Polysciasaponin P3; Chikusetsusaponin 5; Chikusetsusaponin V) exhibits a Ca²⁺-antagonistic antiplatelet effect with an IC₅₀ of 155 μM. Ginsenoside Ro reduces the production of TXA₂ more than it reduces the activities of COX-1 and TXAS.

HY-N0908

Ginsenoside Rg5	IGF-1R NF-κB COX	Cancer Inflammation/Immunology Cardiovascular Disease Endocrinology
Ginsenoside Rg5 is the main component of Red ginseng. Ginsenoside blocks binding of IGF-1 to its receptor with an IC₅₀ of ~90 nM. Ginsenoside Rg5 also inhibits the mRNA expression of *COX-2* via suppression of the DNA binding activities of NF-κB p65.

HY-N0613

Sauchinone	NF-κB	Inflammation/Immunology
Sauchinone is a diastereomeric lignan isolated from Saururus chinensis (Saururaceae). Sauchinone inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation. Sauchinone has anti-inflammatory and antioxidant activity.

HY-N1390

Syringaldehyde	COX	Metabolic Disease Inflammation/Immunology
Syringaldehyde is a polyphenolic compound belonging to the group of flavonoids and is found in different plant species like Manihot esculenta and Magnolia officinalis. Syringaldehyde moderately inhibits *COX-2* activity with an IC₅₀ of 3.5 μg/mL. Anti-hyperglycemic and anti-inflammatory activities.

HY-B0075S

Melatonin D4 N-Acetyl-5-methoxytryptamine D4	Melatonin Receptor Autophagy Mitophagy	Cancer Inflammation/Immunology Neurological Disease
Melatonin D4 is deuterium labeled Melatonin. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Antioxidative and anti-inflammatory properties. Melatonin is a selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation.

HY-N0569

Madecassic acid	NO Synthase COX TNF Receptor Interleukin Related	Inflammation/Immunology
Madecassic acid is isolated from Centella asiatica (Umbelliferae). Madecassic acid has anti-inflammatory properties caused by iNOS, *COX-2, TNF-alpha, IL-1beta, and IL-6* inhibition via the downregulation of NF-κB activation in RAW 264.7 macrophage cells.

HY-N2435

[8]-Shogaol	COX Apoptosis	Cancer
[8]-Shogaol, one of the pungent phenolic compounds in ginger, exhibits anti-platelet activity (IC₅₀=5 μM) and inhibits COX-2 (IC₅₀=17.5 μM). [8]-Shogaol induces apoptosis in human leukemia cells.

HY-N6966

Ethyl Caffeate	NF-κB NO Synthase COX PGE synthase	Inflammation/Immunology Cancer
Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and prostaglandin E₂ (PGE₂) in vitro or in mouse skin.

HY-136477

Pentagamavunon-1 PGV-1	Apoptosis COX VEGFR NF-κB	Cancer
Pentagamavunon-1 (PGV-1), a Curcumin analog with oral activity, targets on several molecular mechanisms to induce apoptosis including inhibition of angiogenic factors cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF). PGV-1 inhibits NF-κB activation.

HY-B0075

Melatonin N-Acetyl-5-methoxytryptamine	Melatonin Receptor Autophagy Mitophagy Endogenous Metabolite	Cancer Inflammation/Immunology Neurological Disease
Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties. Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation.

HY-N0041

Ginsenoside Rb3 Gypenoside IV	NF-κB COX NO Synthase	Cancer Inflammation/Immunology
Ginsenoside Rb3 is extracted from steamed Panax notoginseng. Ginsenoside Rb3 exhibits inhibitory effect on TNFα-induced NF-κB transcriptional activity with an IC₅₀ of 8.2 μM in 293T cell lines. Ginsenoside Rb3 also inhibits the induction of *COX-2* and iNOS mRNA.

HY-N0896

Inulicin 1-O-Acetylbritannilactone	NF-κB COX	Cancer Inflammation/Immunology
Inulicin (1-O-Acetylbritannilactone) is an active compound isolated from Inula Britannica L. Inulicin (1-O-Acetylbritannilactone) inhibits VEGF-mediated activation of Src and FAK. Inulicin (1-O-Acetylbritannilactone) inhibits LPS-induced PGE₂ production and *COX-2* expression, and NF-κB activation and translocation.

HY-100125

Timegadine SR1368	COX	Inflammation/Immunology
Timegadine, a new antiinflammatory agent, is found to be a potent, competitive inhibitor of cyclo-oxygenase (COX) and lipo-oxygenase, with IC₅₀s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates, and in washed rabbit platelets.

HY-101481

Flurbiprofen axetil
COX Inflammation/Immunology

Flurbiprofen axetil is a non-selective cyclooxygenase (COX) inhibitor. Flurbiprofen axetil has anti-inflammatory effect.

HY-135813

LtaS-IN-1	Bacterial	Infection
LtaS-IN-1 (compound 1771) is a potent small-molecule inhibitor of Lipoteichoic acid (LTA) synthesis in multidrug-resistant (MDR) E. faecium and by altering the cell wall morphology. LtaS-IN-1 alone inhibits Enterococcus.spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 combination with antibiotics abolishs multidrug-resistant E. faecium growth almost completely.

HY-125957

A-3 hydrochloride	PKA Casein Kinase CaMK PKC	Others
A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It against PKA (K_i=4.3 µM), casein kinase II (K_i=5.1 µM) and myosin light chain kinase (MLCK) (K_i=7.4 µM). A-3 hydrochloride also inhibits PKC and casein kinase I with K_i values of 47 µM and 80 µM, respectively.

HY-N2106

Dehydroevodiamine	NF-κB COX PGE synthase NO Synthase	Inflammation/Immunology
Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus, has an antiarrhythmic effect in guinea-pig ventricular myocytes. Dehydroevodiamine inhibits LPS-induced iNOS, *COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB*) expression in murine macrophage cells.

HY-N6663

3-Carene	Others	Inflammation/Immunology
3-Carene is a bicyclic monoterpene in essential oils extracted from pine trees. 3-Carene inhibits nociceptive stimulus-induced inflammatory infiltrates and COX-2 overexpression, and with antinociceptive effect. 3-Carene stimulates the activity and expression of alkaline phosphatase that is an early phase marker of osteoblastic differentiation.

HY-N2008

Luteolin 5-O-glucoside	NO Synthase Reactive Oxygen Species	Inflammation/Immunology
Luteolin 5-O-glucoside, a major flavonoidfrom Cirsium maackii, possesses anti-inflammatory activity. Luteolin 5-O-glucoside inhibits LPS-induced NO production and t-BHP-induced ROS generation. Luteolin 5-O-glucoside suppresses the expression of iNOS and COX-2 in macrophages.

HY-B1452

Licofelone ML-3000	COX Lipoxygenase Apoptosis	Cancer Inflammation/Immunology
Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor (IC₅₀=0.21/0.18 μM, respectively) for the treatment of osteoarthritis. Licofelone exerts anti-inflammatory and anti-proliferative effects. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins.

HY-N2459

Peonidin chloride YGM-6 chloride	COX
Peonidin chloride is an O-methylated anthocyanidin that functions as a primary plant pigment, endowing purplish-red hues to flowers such as the peony, from which it takes its name, as well as berries and vegetables. Peonidin chloride exhibits chemopreventive, as well as anti-inflammatory activities on cancer cells in vitro, blocking *COX-2* expression and transformation in JB6 P+ mouse epidermal cells.

HY-N0232

Psoralidin	COX Lipoxygenase Notch Reactive Oxygen Species Bacterial	Cancer
Psoralidin, isolated from the seed of Psoralea corylifolia, is a dual inhibitor of *COX-2* and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation.Anti-cancer, anti-bacterial, and anti-inflammatory properties. Psoralidin significantly downregulates NOTCH1 signaling. Psoralidin also greatly induces ROS generation.

HY-76251

Etodolac
AY-24236
COX Inflammation/Immunology Cancer

Etodolac (AY-24236) is a non-steroidal anti-inflammatory compound that is a non-selective inhibitor of COX (IC₅₀=53.5 nM)

HY-78131B

(R)-(-)-Ibuprofen (R)-Ibuprofen	NF-κB	Inflammation/Immunology Cancer
(R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects.

HY-N0831

Jaceosidin	Bcl-2 Family COX Apoptosis	Cancer Inflammation/Immunology
Jaceosidin is a flavonoid isolated from Artemisia vestita, induces apoptosis in cancer cells, activates Bax and down-regulates Mcl-1 and c-FLIP expression. Jaceosidin exhibits anti-cancer, anti-inflammatory activities, decreases leves of inflammatory markers, and suppresses *COX-2* expression and NF-κB activation.

HY-U00013

Nitroflurbiprofen HCT 1206; NO-flurbiprofen; Nitroxybutyl flurbiprofen	COX	Cardiovascular Disease
Nitroflurbiprofen is a cyclooxygenase (COX) inhibitor with nitric oxide (NO)-donating properties, modulates the increased intrahepatic vascular tone in portal hypertensive cirrhotic rats.

HY-19217

Thioflosulide L-745337	COX	Inflammation/Immunology
Thioflosulide (L-745337) is a selective cyclooxygenase-2 (COX2) inhibitor, with an IC₅₀ of 2.3 nM, and shows anti-inflammatory activity.

HY-N6962

α-Spinasterol	TRP Channel COX	Infection Neurological Disease
α-Spinasterol, isolated from Spinacia oleracea, has antibacterial activity. α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects. α-Spinasterol inhibits *COX-1* andCOX-2 activities with IC₅₀ values of 16.17 μM and 7.76 μM, respectively.

HY-N0603

20(S)-Ginsenoside Rg3 20(S)-Propanaxadiol; S-ginsenoside Rg3	Sodium Channel Potassium Channel NF-κB COX Amyloid-β Endogenous Metabolite	Cancer Inflammation/Immunology Neurological Disease
20(S)-Ginsenoside Rg3 is the main component of Red ginseng. Ginsenoside Rg3 inhibits Na⁺ and hKv1.4 channel with IC₅₀s of 32.2±4.5 and 32.6±2.2 μM, respectively. 20(S)-Ginsenoside Rg3 also inhibits Aβ levels, NF-κB activity, and *COX-2* expression.

HY-101918

DS-1040 Tosylate	Others	Cardiovascular Disease
DS-1040 Tosylate is an orally active, selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) with IC₅₀s of 5.92 nM and 8.01 nM for human and rat TAFIa. DS-1040 Tosylate is a fibrinolysis enhancer for thromboembolic diseases.

HY-18728

STF-31
GLUT Autophagy Cancer

STF-31 is a selective inhibitor of glucose transporter 1 (GLUT1), with an IC₅₀ of 1μM^[1][2].

HY-N0774

Isofraxidin	COX MMP Toll-like Receptor (TLR)	Inflammation/Immunology
Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of ERK1/2 in hepatoma cells. Isofraxidin attenuates the expression of iNOS and *COX-2, Isofraxidinalso inhibits TLR4*/myeloid differentiation protein-2 (MD-2) complex formation.

HY-N0904

Ginsenoside C-K Ginsenoside compound K; Ginsenoside K	COX NO Synthase Cytochrome P450	Inflammation/Immunology
Ginsenoside C-K, a bacterial metabolite of G-Rb1, exhibits anti-inflammatory effects by reducing iNOS and *COX-2. Ginsenoside C-K exhibits an inhibition against the activity of CYP2C9* and CYP2A6 in human liver microsomes with IC₅₀s of 32.0±3.6 μM and 63.6±4.2 μM, respectively.

HY-N2252

Licarin A (+)-Licarin A	TNF Receptor Prostaglandin Receptor COX	Metabolic Disease Inflammation/Immunology Neurological Disease
Licarin A ((+)-Licarin A), a neolignan isolated from various plants, significantly and dose-dependently reduces TNF-α production (IC₅₀=12.6±0.3 μM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells. Anti-allergic effects. Licarin A reduces TNF-α and PGD2 production, and *COX-2* expression。

HY-N2007

Veratric acid 3,4-Dimethoxybenzoic acid	COX Reactive Oxygen Species	Inflammation/Immunology Cardiovascular Disease
Veratric acid (3,4-Dimethoxybenzoic acid) is an orally active phenolic compound derived from vegetables and fruits, has antioxidant and anti-inflammatory activities. Veratric acid also acts as a protective agent against hypertension-associated cardiovascular remodelling. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation.

HY-B1355A

Oxyphenbutazone	COX Bacterial	Cancer Infection Inflammation/Immunology
Oxyphenbutazone is a phenylbutazone derivative, with anti-inflammatory effect. Oxyphenbutazone is a non-selective *COX* inhibitor. Oxyphenbutazone selectively kills non-replicating Mycobaterium tuberculosis.

HY-126052

Gnetol	COX Tyrosinase HDAC	Cancer Metabolic Disease
Gnetol is a phenolic compound isolated from the root of Gnetum ula Brongn. Gnetol potently inhibits *COX-1* (IC₅₀ of 0.78 μM) and HDAC. Gnetol is a potent tyrosinase inhibitor with an IC₅₀ of 4.5 μM for murine tyrosinase and suppresses melanin biosynthesis. Gnetol has antioxidant, antiproliferative, anticancer and hepatoprotective activity. Gnetol also possesses concentration-dependent α-Amylase, α-glucosidase, and adipogenesis activities.

HY-W018643

Ferulic acid methyl ester Methyl ferulate	p38 MAPK Autophagy	Inflammation/Immunology Neurological Disease Cancer
Ferulic acid methyl ester (Methyl ferulate) is a derivative of ferulic acid, isolated from Stemona tuberosa, with anti-inflammatory and antioxidant properties. Ferulic acid methyl ester is a cell membrane and brain permeable compound, shows free radical scavenging ability, used in the research of neurodegenerative disorders. Ferulic acid methyl ester inhibits COX-2 expression, blocks p-p38 and p-JNK in primary bone marrow derived-macrophages.

HY-15583

Auristatin F	Microtubule/Tubulin ADC Cytotoxin	Cancer
Auristatin F is a potent cytotoxin. Auristatin F, a potent microtubule inhibitor and vascular damaging agent (VDA), can be used in antibody-drug conjugates (ADC).

HY-N1942

5-O-Demethylnobiletin 5-Demethylnobiletin	Lipoxygenase Leukotriene Receptor	Inflammation/Immunology Neurological Disease Cancer
5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Sideritis tragoriganum, is a direct inhibition of 5-LOX (IC₅₀=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB₄) formation in rat neutrophils and elastase release in human neutrophils with an IC₅₀ of 0.35 μM.

HY-18342

Diflunisal MK-647	COX	Inflammation/Immunology Cancer
Diflunisal (MK-647) is a salicylate derivative with nonsteroidal anti-inflammatory and uricosuric properties, which is used alone as an analgesic and in rheumatoid arthritis patients. The mechanism of action of diflunisal is as a Cyclooxygenase (COX) Inhibitor.

HY-N1435

Oroxin B	Apoptosis PI3K PTEN Autophagy	Cancer
Oroxin B (OB) is a flavonoid isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent. Oroxin B (OB) possesses obvious inhibitory effect and induces early apoptosis rather than late apoptosis on liver cancer cells through upregulation of PTEN, down regulation of COX-2, VEGF, PI3K, and p-AKT. Oroxin B (OB) selectively induces tumor-suppressive ER stress in malignant lymphoma cells.

HY-N0811

Anemarsaponin B	NO Synthase COX NF-κB	Inflammation/Immunology
Anemarsaponin B is a steroidal saponin isolated from the rhizomes of A. asphodeloides (Liliaceae). Anemarsaponin B decreases the protein and mRNA levels of iNOS and *COX-2. Anemarsaponin B reduces the expressions and productions of pro-inflammatory cytokines, including TNF-a and IL-6. Anemarsaponin B inhibits the nuclear translocation of the p65 subunit of NF-κB* by blocking the phosphorylation of IκBα. Anemarsaponin B also inhibits the phosphorylation of MAP kinase kinases 3/6 (MKK3/6) and mixed lineage kinase 3 (MLK3). Anti-inflammatory effect .

HY-N0632

Esculentoside A	COX NF-κB	Inflammation/Immunology
Esculentoside A (EsA), a kind of triterpene saponin isolated from roots of Phytolacca esculenta. Esculentoside A (EsA) possesses anti-inflammatory activity in acute and chronic experimental models, has selective inhibitory activity towards cyclooxygenase-2 (COX-2). Esculentoside A (EsA) suppresses inflammatory responses in LPS-induced acute lung injury (ALI) through inhibition of the nuclear factor kappa B (NF-ΚB) and mitogen activated protein kinase (MAPK) signaling pathways.

HY-B1221

Flufenamic acid	COX AMPK Potassium Channel Chloride Channel Calcium Channel Parasite	Inflammation/Immunology
Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca²⁺ channels, modulating non-selective cation channels (NSC), activating K⁺ channels.

HY-18763

Indobufen Ibustrin	COX	Cardiovascular Disease
Indobufen is a platelet aggregation inhibitor. Indobufen is a reversible platelet cyclooxygenase (Cox) activity inhibitor. Indobufen suppresses thromboxane A₂ (TxA₂) synthesis. Indobufen down-regulates tissue factor (TF) in monocytes.

HY-129974

3,3'-Diiodo-L-thyronine 3,3'-T2	Endogenous Metabolite COX	Metabolic Disease
3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances *COX* activity.

HY-122470

Stampidine	Reverse Transcriptase HIV	Infection
Stampidine is a nucleoside reverse transcriptase inhibitor (NRTI) with potent and broad-spectrum anti-HIV activity. Stampidine inhibits the laboratory HIV-1 strain HTLV_IIIB (B-envelope subtype) and primary clinical isolates with IC₅₀s of 1 nM and 2 nM, respectively. Stampidine also inhibits NRTI-resistant primary clinical isolates and NNRTI-resistant clinical isolates with IC₅₀s of 8.7 nM and 11.2 nM, respectively.

HY-123823

Nitroaspirin NCX 4016	COX Apoptosis	Cancer
Nitroaspirin (NCX 4016) is a nitric oxide (NO) donor and a nitro-derivative of Aspirin, which combines with Nitroaspirin to inhibit cyclooxygenase. Nitroaspirin (NCX 4016) has antithrombotic and anti-platelet properties and acts as a direct and irreversible inhibitor of *COX-1. Nitroaspirin (NCX 4016) causes significant induction of cell cycle arrest and apoptosis* in Cisplatin-resistant human ovarian cancer cells via down-regulation of EGFR/PI3K/STAT3 signaling and modulation of Bcl-2 family proteins.

HY-N6257

Cafestol	ERK PGE synthase COX NF-κB	Cancer Inflammation/Immunology
Cafestol, one of the major components of coffee, is a coffee-specific diterpene from. Cafestol is a ERK inhibitor for AP-1-targeted activity against PGE₂ production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE₂ production by suppressing the NF-kB activation pathway. Cafestol contributes to its beneficial effects through various biological activities such as chemopreventive, antitumorigenic, hepatoprotective, antioxidative and antiinflammatory effects.

HY-106579

Tiaprofenic acid	COX	Inflammation/Immunology
Tiaprofenic acid is an orally active nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic potency. Tiaprofenic acid inhibits prostaglandin synthesis by suppressing cyclo-oxygenase (COX). Tiaprofenic acid can be used in the treatment of rheumatic diseases.

HY-N0043

Ginsenoside Rd Gypenoside VIII	NF-κB COX Calcium Channel Cytochrome P450 Endogenous Metabolite	Inflammation/Immunology Cardiovascular Disease Cancer
Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC₅₀ of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of *COX-2* and iNOS mRNA. Ginsenoside Rd also inhibits Ca²⁺ influx. Ginsenoside Rd inhibits CYP2D6, CYP1A2, CYP3A4, and CYP2C9, with IC₅₀s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively.

HY-106628

Sudoxicam	COX	Inflammation/Immunology
Sudoxicam is a reversible and orally active *COX* antagonist and a non-steroidal anti-inflammatory drug (NSAID) from the enol-carboxamide class. Sudoxicam has potent anti-inflammatory, anti-edema and antipyretic activity.

HY-11007

GNF-2
Bcr-Abl SARS-CoV Cancer

GNF-2 is a highly selective, allosteric, non-ATP competitive inhibitor of Bcr-Abl. GNF-2 inhibits Ba/F3.p210 proliferation with an IC₅₀ of 138 nM .

HY-N7148

γ-Tocopherol D-γ-Tocopherol; (+)-γ-Tocopherol	COX	Cancer Inflammation/Immunology
γ-Tocopherol (D-γ-Tocopherol) is a potent cyclooxygenase (COX) inhibitor. γ-Tocopherol is a naturally occurring form of Vitamin E in many plant seeds, such as corn oil and soybeans. γ-Tocopherol possesses antiinflammatory properties and anti-cancer activity.

HY-135731

4-Methylamino antipyrine	COX Drug Metabolite	Inflammation/Immunology
4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits *COX*. Metamizole is an nonopioid analgesic drug and can be used for pain and fever. 4-Methylamino antipyrine has analgesic, antipyretic, and relatively weak antiinflammatory properties.

HY-107416

RHC 80267 U-57908	Acyltransferase mAChR COX Phospholipase	Metabolic Disease Neurological Disease
RHC 80267 (U-57908) is a potent and selective inhibitor of diacylglycerol lipase (DAGL) (with IC₅₀ of 4 μM in canine platelets). RHC-80267 inhibits cholinesterase activity with an IC₅₀ of 4 μM, thereby enhancing the relaxation evoked by acetylcholine. RHC 80267 also inhibits *COX* and the hydrolysis of phosphatidylcholine (PC).

HY-105024

FPL 62064	Lipoxygenase COX	Inflammation/Immunology
FPL 62064 is a potent 5-lipoxygenase (5-LOX) and *COX* dual inhibitor, with IC₅₀ values of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase (cyclooxygenase), respectively. FPL 62064 has potent anti-inflammatory activity.

HY-135731A

4-Methylamino antipyrine hydrochloride	COX Drug Metabolite	Inflammation/Immunology
4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits *COX*. Metamizole is an nonopioid analgesic drug and can be used for pain and fever. 4-Methylamino antipyrine hydrochloride has analgesic, antipyretic, and relatively weak antiinflammatory properties.

HY-Y0189

Methyl Salicylate Wintergreen oil	COX	Inflammation/Immunology
Methyl Salicylate (Wintergreen oil) is a topical analgesic and anti-inflammatory agent. Also used as a pesticide, a denaturant, a fragrance ingredient, and a flavoring agent in food and tobacco products. A systemic acquired resistance (SAR) signal in tobacco. A topical nonsteroidal anti-inflammatory drug (NSAID). Methyl salicylate lactoside is a COX inhibitor.

HY-128463

N-tert-Butyl-α-phenylnitrone	COX Reactive Oxygen Species	Metabolic Disease Inflammation/Immunology Neurological Disease
N-tert-Butyl-α-phenylnitrone is a nitrone-based free radical scavenger that forms nitroxide spin adducts. N-tert-Butyl-α-phenylnitrone inhibits *COX2* catalytic activity. N-tert-Butyl-α-phenylnitrone has potent ROS scavenging, anti-inflammatory, neuroprotective, anti-aging and anti-diabetic activities, and can penetrate the blood-brain barrier.

HY-N0222

Avicularin	Others	Cancer Inflammation/Immunology
Avicularin is a bio-active flavonoid from plants, anti-inflammatory, anti-allergic, anti-oxidant, hepatoprotective, and anti-tumor activities. Avicularin exhibits anti-inflammatory activity through the suppression of ERK signaling pathway in LPS-stimulated RAW 264.7 macrophage cells. Avicularin ameliorates human hepatocellular carcinoma via the regulation of NF κB (p65), COX 2 and PPAR γ activities.

HY-122872

MKK7-COV-9	p38 MAPK	Cancer
MKK7-COV-9 is a potent and selective covalent inhibitor of MKK7 and targets a specific protein–protein interaction of MKK7. MKK7-COV-9 blocks primary B cell activation in response to LPS with an EC₅₀ of 4.98 μM.

HY-129611

Bromelain	Apoptosis	Cancer Inflammation/Immunology
Bromelain is an anti-inflammatory drug derived from pineapple stem that acts through down-regulation of plasma kininogen, inhibition of Prostaglandin E2 expression, degradation of advanced glycation end product receptors and regulation of angiogenic biomarkers as well as antioxidant action upstream in the *COX*-pathway. Bromelain exhibits various fibrinolytic, antiedematous, antithrombotic, and anti-inflammatory activities. Bromelain also possesses some anticancerous activities and promotes apoptotic cell death.

HY-120944

BAY-7598	MMP	Inflammation/Immunology
BAY-7598 is a potent, orally bioavailable, and selective MMP12 inhibitor probe with IC₅₀s of 0.085, 0.67 and 1.1 nM for human MMP12, murine MMP12, and rat MMP12, respectively.

Cat. No.	Product Name

HY-L0067V

Immuno-Oncology Library 52,935 compounds

A unique collection of 52,935 diverse compounds designed for discovery of novel hits in immuno-oncology therapeutic area has been offered.
HY-L034

Anti-Aging Compound Library 2299 compounds

A unique collection of 2299 bioactive anti-aging compounds for high throughput screening (HTS) and high content screening (HCS).

HY-L007

Immunology/Inflammation Compound Library

1676 compounds

The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease. To function properly, an immune system must detect a wide variety of agents, known as pathogens, from viruses to parasitic worms, and distinguish them from the organism's own healthy tissue. Inflammation is also the body's attempt at self-protection to remove harmful stimuli and begin the healing process. It’s part of the body's immune response. The immune system recognizes damaged cells, irritants, and pathogens, and inflammation begins the healing process. Inflammatory abnormalities are a large group of disorders that underlie a vast variety of human diseases. The immune system is often involved with inflammatory disorders, demonstrated in both allergic reactions and some myopathies, with many immune system disorders resulting in abnormal inflammation.

MCE designs a unique collection of 1676 compounds that are useful tool for Immunology/Inflammation research or autoimmune inflammatory diseases drug discovery.

Cat. No.	Product Name	Target	Category

HY-B0367

Lornoxicam
Chlortenoxicam; Ro 13-9297; TS110
COX Endogenous Metabolite Natural Products

Lornoxicam, a COX-1 and COX-2 inhibitor, is a new nonsteroidal anti-inflammatory drug (NSAID).