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Azido-PEG4-Val-Cit-PAB-MMAE

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Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W190943
    Azido-PEG4-Val-Cit-PAB-MMAE

    		Drug-Linker Conjugates for ADC Cancer
    Azido-PEG4-Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the cleavable linker Azido-PEG4-Val-Cit-PAB-OH . Azido-PEG4-Val-Cit-PAB-MMAE is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
    <em>Azido-PEG4</em>-Val-Cit-PAB-<em>MMAE</em>

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