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Results for "

BACE

" in MCE Product Catalog:

By Targets:	Beta-secretase (48) Amyloid-β (5) Apoptosis (1) Autophagy (1) Cholinesterase (ChE) (8) GSK-3 (1) Microtubule/Tubulin (1) Phosphatase (1) Phosphodiesterase (PDE) (1) PI3K (1) Reactive Oxygen Species (1) ROS Kinase (2)
By Research Areas:	Cancer (4) Inflammation/Immunology (3) Metabolic Disease (3) Neurological Disease (45)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Targets Recommended: Beta-secretase

Cat. No.	Product Name	Target	Research Areas

HY-147758

BACE1/2-IN-1	Beta-secretase Amyloid-β	Neurological Disease
BACE1/2-IN-1 (compound 34) is a potent *BACE1* and *BACE2* inhibitor, with an IC₅₀ of 0.01 and 0.0053 μM, respectively. BACE1/2-IN-1 shows a combination of lower Pgp efflux ratio and improved passive permeability. BACE1/2-IN-1 displays reduced liver microsomal metabolic stability.

HY-151348

BACE1-IN-11	Beta-secretase	Neurological Disease
BACE1-IN-11 is a *BACE1* inhibitor. BACE1-IN-11 has the BACE1 inhibitory activity with an IC₅₀ value of 72 μM. BACE1-IN-11 can be used for the research of Alzheimer’s disease (AD) .

HY-P3426

BACE1-IN-10
Beta-secretase Cancer

BACE1-IN-10 is a potent BACE1 Inhibitor. BACE1-IN-10 shows sub-micromolar activity against recombinant BACE1 (rBACE1).
HY-100182

BACE1-IN-1
Beta-secretase Neurological Disease

BACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC₅₀s of 32 and 47 nM for human BACE1 and BACE2, respectively.

BACE1-IN-10	Beta-secretase	Cancer
BACE1-IN-10 is a potent *BACE1* Inhibitor. BACE1-IN-10 shows sub-micromolar activity against recombinant BACE1 (rBACE1).

BACE1-IN-1	Beta-secretase	Neurological Disease
BACE1-IN-1 is a potent and highly brain penetrant *BACE1* inhibitor with IC₅₀s of 32 and 47 nM for human BACE1 and BACE2, respectively.

HY-147851

BACE1-IN-12	Beta-secretase	Neurological Disease
BACE1-IN-12 (compound 7g) is a potent and BBB-penetrated *BACE1* inhibitor, with an IC₅₀ of 8.9 µM. BACE1-IN-12 shows selective BuChE (butyrylcholinesterase) inhibitory activity with an IC₅₀ of 3.2 µM. BACE1-IN-12 shows effective antioxidant effect with an IC₅₀ of 10.2 μM (DPPH). BACE1-IN-12 might be served as a potential anti-Alzheimer agent.

HY-145345

BACE1-IN-6
Beta-secretase Neurological Disease

BACE1-IN-6 is a BACE1 inhibitor with an IC₅₀ value of 1.5 nM.

BACE1-IN-6	Beta-secretase	Neurological Disease
BACE1-IN-6 is a *BACE1* inhibitor with an IC₅₀ value of 1.5 nM.

HY-128594

BACE1-IN-4	Beta-secretase	Neurological Disease
BACE1-IN-4 is a potent and highly selective *BACE1* inhibitor, with an IC₅₀ of 3.8 nM and a K_i of 1.9 nM, more selective at BACE1 over BACE2. Anti-Alzheimer’s disease.

HY-131068

BACE-1 inhibitor 2
Beta-secretase Neurological Disease

BACE-1 inhibitor 2 is a potent and CNS permeable BACE-1 inhibitor with an IC₅₀ of 1.5 nM in BACE-1 enzymatic assay.

BACE-1 inhibitor 2	Beta-secretase	Neurological Disease
BACE-1 inhibitor 2 is a potent and CNS permeable *BACE-1* inhibitor with an IC₅₀ of 1.5 nM in BACE-1 enzymatic assay.

HY-136742

BACE2-IN-1	Beta-secretase	Metabolic Disease
BACE2-IN-1 (compound 3l) is a highly selective *BACE2* inhibitor with a Kⁱ value of 1.6 nM. BACE2 inhibitors can be used to research of Type 2 Diabetes.

HY-112297

BACE-1 inhibitor 1
Beta-secretase Neurological Disease

BACE-1 inhibitor 1 (Compound 8a) is a potent BACE-1 inhibitor with an IC₅₀ of 56 nM.
HY-112444

BACE1-IN-2
Beta-secretase Neurological Disease

BACE1-IN-2 is a 1,4-Oxazine β-Secretase 1 (BACE1) inhibitor with an IC₅₀ of 22 nM.

BACE-1 inhibitor 1	Beta-secretase	Neurological Disease
BACE-1 inhibitor 1 (Compound 8a) is a potent *BACE-1* inhibitor with an IC₅₀ of 56 nM.

BACE1-IN-2	Beta-secretase	Neurological Disease
BACE1-IN-2 is a 1,4-Oxazine β-Secretase 1 (BACE1) inhibitor with an IC₅₀ of 22 nM.

HY-130244

BACE1-IN-5	Beta-secretase	Neurological Disease
BACE1-IN-5 (Compound 15) is a β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC₅₀ of 9.1 nM, and also inhibits cellular amyloid-β (Aβ) with an IC₅₀ of 0.82 nM. BACE1-IN-5 has a medicinal chemistry that improves hERG inhibition and P-gp efflux.

HY-144739

BACE1-IN-8
Beta-secretase Neurological Disease

BACE1-IN-8 (compound 70b) is a potent BACE1 (β-site APP cleaving enzyme 1) inhibitor, with an IC₅₀ of 3.9 µM.
HY-144741

BACE1-IN-9
Beta-secretase Neurological Disease

BACE1-IN-9 (compound 82b) is a potent BACE1 (β-site APP cleaving enzyme 1) inhibitor, with an IC₅₀ of 1.2 µM.

BACE1-IN-8	Beta-secretase	Neurological Disease
BACE1-IN-8 (compound 70b) is a potent *BACE1* (β-site APP cleaving enzyme 1) inhibitor, with an IC₅₀ of 3.9 µM.

BACE1-IN-9	Beta-secretase	Neurological Disease
BACE1-IN-9 (compound 82b) is a potent *BACE1* (β-site APP cleaving enzyme 1) inhibitor, with an IC₅₀ of 1.2 µM.

HY-U00287

BACE-IN-1	Beta-secretase	Neurological Disease
BACE-IN-1 (Compound 13) is a substituted lmidazo[1 ,2-a]pyridine derivative which can inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment of diseases in which BACE is involved, such as Alzheimer's disease.

HY-147658

*AChE/BChE/BACE-1-IN-1*	Cholinesterase (ChE) Beta-secretase ROS Kinase	Neurological Disease
AChE/BChE/BACE-1-IN-1 (Compound 4k) is an orally active inhibitor of AChE, BChE, and *BACE-1* with IC₅₀ values of 0.058, 0.082 and 0.115 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-1 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-1 has remarkable antioxidant potential.

HY-147659

*AChE/BChE/BACE-1-IN-2*	Cholinesterase (ChE) Beta-secretase ROS Kinase	Neurological Disease
AChE/BChE/BACE-1-IN-2 (Compound 4o) is an orally active inhibitor of AChE, BChE, and *BACE-1* with IC₅₀ values of 0.069, 0.127 and 0.097 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-2 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-2 has remarkable antioxidant potential.

HY-151260

*AChE/BACE1/GSK3β-IN-1*	Beta-secretase Cholinesterase (ChE) GSK-3	Neurological Disease
AChE/BACE1/GSK3β-IN-1 is an orally active triple inhibitor of *AChE/BACE1/GSK3β. AChE/BACE1/GSK3β-IN-1 has effective inhibitory activity against AChE, BACE1 and GSK3β with IC₅₀* values of 1.0 μM, 20 μM and 15 μM, respectively. AChE/BACE1/GSK3β-IN-1 has good blood-brain barrier penetrability, suitable bioavailability. AChE/BACE1/GSK3β-IN-1 can be used for the research of Alzheimer's disease (AD).

HY-119689

Umibecestat CNP520	Beta-secretase	Neurological Disease
Umibecestat (CNP520) is a beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) inhibitor with IC₅₀s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively. Umibecestat can be used for the research of alzheimer's disease.

HY-10133

β-Secretase Inhibitor IV	Beta-secretase	Neurological Disease
β-Secretase Inhibitor IV is a potent, cell-active *BACE-1* inhibitor with IC₅₀s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively.

HY-124322

NB-360	Beta-secretase	Inflammation/Immunology Neurological Disease
NB-360 is a potent, brain penetrable, and orally bioavailable dual *BACE1/BACE2* inhibitor (IC₅₀: mouse and human BACE1=5 nM; BACE2=6 nM). NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in amyloid precursor protein(APP) transgenic mice. NB-360 can completely block the progression of Aβ deposition in the brains of APP transgenic mice. NB-360 shows excellent selectivity over the related aspartyl proteases pepsin, cathepsin D and cathepsin E.

HY-N4186

Glabrolide
Beta-secretase Neurological Disease

Glabrolide, derived from Glycyrrhiza uralensis Fisch., is a β-secretase 1 (BACE-1) inhibitor[1].

Glabrolide	Beta-secretase	Neurological Disease
Glabrolide, derived from Glycyrrhiza uralensis Fisch., is a β-secretase 1 (BACE-1) inhibitor[1].

HY-12938

AMG-8718	Beta-secretase	Neurological Disease
AMG-8718 is a potent, selective and orally active *BACE1* inhibitor with IC₅₀ values of 0.0007, 0.005 µM for BACE1 and BACE2, respectively. AMG-8718 significantly decreases Aβ₄₀ levels in the CSF and brain.

HY-N0495

Aloenin Aloenin A	Beta-secretase	Neurological Disease
Aloenin (Aloenin A) is a natural compound, which has potent peroxyl radical-scavenging activities and moderate inhibitory active on β-secretase (BACE).

HY-109055

Elenbecestat E2609	Beta-secretase	Neurological Disease
Elenbecestat (E2609) is a potent, orally bioavailable and CNS-penetrant *BACE-1* inhibitor. Elenbecestat has the potential for Alzheimer's disease (AD) research.

HY-112157

PF-06751979	Beta-secretase	Neurological Disease
PF-06751979 is a potent, brain penetrant, β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC₅₀ of 7.3 nM in BACE1 binding assay.

HY-10472

LY2811376	Beta-secretase	Neurological Disease
LY2811376 is the first orally available non-peptidic β-secretase (BACE1) inhibitor with IC₅₀ of 239 nM-249 nM, that acts to decrease Aβ secretion with EC₅₀ of 300 nM, and demonstrates to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin.

HY-16759

Verubecestat MK-8931	Beta-secretase	Neurological Disease
Verubecestat (MK-8931) is an orally active, high-affinity *BACE1* and *BACE2* inhibitor with K_i values of 2.2 nM and 0.38 nM. Verubecestat effectively reduces Aβ40 and has the potential for Alzheimer's Disease.

HY-13240

LY2886721	Beta-secretase	Neurological Disease
LY2886721 is a potent, selective and orally active beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC₅₀ of 20.3 nM for recombinant human *BACE1. LY2886721 is selectivity against cathepsin D, pepsin, and renin, but lacking selectivity against BACE2* (IC₅₀ of 10.2 nM). LY2886721 can across blood-brain barrier and has the potential for Alzheimer's disease treatment.

HY-139720

β-Secretase Inhibitor III
Beta-secretase Neurological Disease

β-Secretase Inhibitor III is an extremely selective BACE1 inhibitor (K_i = 0.13 nM).

β-Secretase Inhibitor III	Beta-secretase	Neurological Disease
β-Secretase Inhibitor III is an extremely selective *BACE1* inhibitor (K_i = 0.13 nM).

HY-128774

AM-6494	Beta-secretase	Neurological Disease
AM-6494 is a potent and orally active *BACE1* (efficacious β-site amyloid precursor protein cleaving enzyme 1) inhibitor (IC₅₀=0.4 nM) with in vivo selectivity over BACE2 (IC₅₀=18.6 nM).

HY-132895

JNJ-67569762
Beta-secretase Neurological Disease

JNJ-67569762 is a selective BACE1 inhibitor targeting the S3 pocket (IC₅₀ = 2.7 nM).

JNJ-67569762	Beta-secretase	Neurological Disease
JNJ-67569762 is a selective *BACE1* inhibitor targeting the S3 pocket (IC₅₀ = 2.7 nM).

HY-N1280

Semilicoisoflavone B	Amyloid-β	Neurological Disease
Semilicoisoflavone B, an isoflavone, mainly derived from Glycyrrhiza uralensis Fisch.. Semilicoisoflavone B reduces amyloid β (Aβ) secretion by inhibiting β-secretase-1 (BACE1) expression and activity. Semilicoisoflavone B decreases BACE1 expression mainly through increasing PPARγ expression and inhibiting STAT3 phosphorylation.

HY-122080

Memoquin	Cholinesterase (ChE) Beta-secretase Amyloid-β	Neurological Disease
Memoquin is an anti-amyloid and anti-oxidant multi-target-directed ligand. Memoquin is an orally active inhibitor of *BACE-1* and AChE with IC₅₀ values of 108 and 1.55 nM, respectively. Memoquin is a cognitive enhancer that prevents the Aβ-induced neurotoxicity mediated by oxidative stress. Memoquin can be used for the research of Alzheimer’s disease (AD).

HY-N2215

Aloeresin D
Beta-secretase Neurological Disease

Aloeresin D is a chromone glycoside isolated from Aloe vera, inhibits β-Secretase (BACE1) activity, with an IC₅₀ of 39 μM.

Aloeresin D	Beta-secretase	Neurological Disease
Aloeresin D is a chromone glycoside isolated from Aloe vera, inhibits β-Secretase (BACE1) activity, with an IC₅₀ of 39 μM.

HY-100740

Lanabecestat AZD3293; LY3314814	Beta-secretase	Neurological Disease
Lanabecestat (AZD3293) is a potent, orally active and blood-brain barrier penetrating *BACE1* inhibitor with a K_i of 0.4 nM. Lanabecestat is used for the research of Alzheimer's disease.

HY-13438

AZD3839 free base	Beta-secretase	Cancer
AZD3839 free base is a potent and selective orally active, brain-permeable *BACE1* inhibitor (K_i=26 nM). AZD3839 free base shows 14 and >1000-fold selectivity against BACE2 and cathepsin D, respectively. AZD3839 free base exhibits dose- and time-dependent lowering of plasma, brain, and cerebrospinal fluid Aβ levels in mouse, guinea pig, and non-human primate. AZD3839 free base can be used for the research of Alzheimer's disease.

HY-N7887

Cassiaside	Beta-secretase	Inflammation/Immunology Neurological Disease
Cassiaside is a naphthopyrone glucoside, shows mixed-type inhibition against *BACE1* (IC₅₀=4.45 μM; K_i=9.85 μM). Cassiaside possesses potential anti- Alzheimer's disease (AD) activity.

HY-N1255

Scoulerine (-)-Scoulerine; Discretamine	Microtubule/Tubulin Beta-secretase Apoptosis	Cancer
Scoulerine ((-)-Scoulerine), an isoquinoline alkaloid, is a potent antimitotic compound. Scoulerine is also an inhibitor of *BACE1* (ß-site amyloid precursor protein cleaving enzyme 1). Scoulerine inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells.

HY-108966

Kushenol C	Beta-secretase	Inflammation/Immunology
Kushenol C, isolated from the roots of Sophora flavescens, shows anti-Inflammatory and anti-oxidative stress activities. Kushenol C inhibits BACE1 (β-site APP cleaving enzyme 1) with an IC₅₀ of 5.45 µM.

HY-111383

LX2343	Beta-secretase PI3K Amyloid-β Autophagy	Neurological Disease
LX2343 is a *BACE1* enzyme inhibitor with an IC₅₀ value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC₅₀ of 15.99±3.23 μM. LX2343 stimulates autophagy in its promotion of Aβ clearance.

HY-P2713

OM99-2	Beta-secretase	Neurological Disease
OM99-2, an eight residue peptidomimetic, tight-binding inhibitor of human brain memapsin 2 with a K_i value of 9.58 nM. OM99-2 is significantly advanced the development of BACE1 inhibitor. OM99-2 has the potential for the research of the Alzheimer's disease.

HY-N0249

Saikosaponin C	Amyloid-β	Neurological Disease
Saikosaponin C is a bioactive component found in radix bupleuri, targets amyloid beta and tau in Alzheimer's disease. Saikosaponin C inhibits the secretion of both Aβ1-40 and Aβ1-42, and suppresses abnormal tau phosphorylation, but shows no effect on BACE1 activity and expression.

HY-109052

Atabecestat JNJ-54861911	Beta-secretase	Neurological Disease
Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust and high CSF Aβ reduction. Atabecestat s tolerated and displays a sustained pharmacokinetic (PK) and pharmacodynamic (PD) characteristics. Atabecestat has the potential for Alzheimer's Disease treatment.

HY-N3734

Deoxyneocryptotanshinone	Beta-secretase Phosphatase	Neurological Disease
Deoxyneocryptotanshinone, a natural tanshinone, is a high affinity *BACE1* (Beta-secretase) inhibitor with an IC₅₀ value of 11.53 μM. Deoxyneocryptotanshinone shows a promising dose-dependent inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC₅₀ value of 133.5 μM. Deoxyneocryptotanshinone can be used for Alzheimer's disease research.

HY-100740C

(1α,1'S,4β)-Lanabecestat (1α,1'S,4β)-AZD3293; (1α,1'S,4β)-LY3314814	Beta-secretase	Neurological Disease
(1α,1'S,4β)-Lanabecestat ((1α,1'S,4β)-AZD3293) a less active enantiomer of Lanabecestat. Lanabecestat is a potent, orally active and blood-brain barrier penetrating BACE1 inhibitor with a K_i of 0.4 nM.

HY-P2713A

OM99-2 TFA	Beta-secretase	Neurological Disease
OM99-2 TFA, an eight residue peptidomimetic, tight-binding inhibitor of human brain memapsin 2 with a K_i value of 9.58 nM. OM99-2 TFA is significantly advanced the development of BACE1 inhibitor. OM99-2 has the potential for the research of the Alzheimer's disease.

HY-N2284

Sophoflavescenol	Cholinesterase (ChE) Beta-secretase Phosphodiesterase (PDE)	Cancer
Sophoflavescenol is a prenylated flavonol, which shows great inhibitory activity with IC₅₀ of 0.013 μM against Phosphodiesterase 5 (PDE5), and also inhibits RLAR, HRAR, AGE, BACE1, AChE and BChE with IC₅₀s of 0.30 µM, 0.17 µM, 17.89 µg/mL, 10.98 µM, 8.37 µM and 8.21 µM, respectively.

HY-115973

AChE-IN-11	Cholinesterase (ChE)	Neurological Disease
AChE-IN-11 (compound 5C) is a good multifunctional agent (AChE IC₅₀ = 7.9 μM, MAO-B IC₅₀ = 9.9 μM, BACE1 IC₅₀ = 8.3 μM). AChE-IN-11 displays a mixed-type AChE inhibition, which can bind to the CAS and PAS of AChE. AChE-IN-11 also exhibits good antioxidant activity (ORAC = 2.5 eq) and neuroprotective effects. AChE-IN-11 is a selective metal ions chelator. AChE-IN-11 has the potential for the research of AD.

HY-N0226

Epiberberine	Cholinesterase (ChE) Beta-secretase	Metabolic Disease Neurological Disease
Epiberberine is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive *BACE1* inhibitor, with IC₅₀s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine has antioxidant activity, with peroxynitrite ONOO^- scavenging effect (IC₅₀, 16.83 μM), and can be used for the research of Alzheimer disease. Epiberberine inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways. Epiberberinecan be used for the research of diabetic disease.

HY-N0226A

Epiberberine chloride	Cholinesterase (ChE) Beta-secretase Reactive Oxygen Species	Metabolic Disease Neurological Disease
Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive *BACE1* inhibitor, with IC₅₀s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO^- scavenging effect (IC₅₀, 16.83 μM), and may protect against Alzheimer disease. Epiberberine chloride inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways. Epiberberine has the potential effect in the research of diabetic disease.

Cat. No.	Product Name	Target	Research Area

HY-P3426

BACE1-IN-10
Beta-secretase Cancer

BACE1-IN-10 is a potent BACE1 Inhibitor. BACE1-IN-10 shows sub-micromolar activity against recombinant BACE1 (rBACE1).

HY-P2713

OM99-2	Beta-secretase	Neurological Disease
OM99-2, an eight residue peptidomimetic, tight-binding inhibitor of human brain memapsin 2 with a K_i value of 9.58 nM. OM99-2 is significantly advanced the development of BACE1 inhibitor. OM99-2 has the potential for the research of the Alzheimer's disease.

HY-P2713A

OM99-2 TFA	Beta-secretase	Neurological Disease
OM99-2 TFA, an eight residue peptidomimetic, tight-binding inhibitor of human brain memapsin 2 with a K_i value of 9.58 nM. OM99-2 TFA is significantly advanced the development of BACE1 inhibitor. OM99-2 has the potential for the research of the Alzheimer's disease.

Cat. No.	Product Name	Target	Category

HY-N4186

Glabrolide	Beta-secretase	Terpenoids Triterpenes Source classification Plants Leguminosae Glycyrrhiza uralensis Fisch.
Glabrolide, derived from Glycyrrhiza uralensis Fisch., is a β-secretase 1 (BACE-1) inhibitor[1].

HY-N0495

Aloenin Aloenin A	Beta-secretase	Phenols Source classification Plants Liliaceae Aloe vera (Linn.) N. L. Burman var. chinensis (Haw.) Berg.
Aloenin (Aloenin A) is a natural compound, which has potent peroxyl radical-scavenging activities and moderate inhibitory active on β-secretase (BACE).

HY-N1280

Semilicoisoflavone B	Amyloid-β	Flavonoids Isoflavones Phenols Polyphenols Source classification Plants Leguminosae Glycyrrhiza uralensis Fisch.
Semilicoisoflavone B, an isoflavone, mainly derived from Glycyrrhiza uralensis Fisch.. Semilicoisoflavone B reduces amyloid β (Aβ) secretion by inhibiting β-secretase-1 (BACE1) expression and activity. Semilicoisoflavone B decreases BACE1 expression mainly through increasing PPARγ expression and inhibiting STAT3 phosphorylation.

HY-N2215

Aloeresin D	Beta-secretase	Phenylpropanoids Simple Phenylpropanols Phenols Monophenols Source classification Plants Liliaceae Aloe vera (Linn.) N. L. Burman var. chinensis (Haw.) Berg.
Aloeresin D is a chromone glycoside isolated from Aloe vera, inhibits β-Secretase (BACE1) activity, with an IC₅₀ of 39 μM.

HY-N7887

Cassiaside	Beta-secretase	Phenols Polyphenols Source classification Plants Leguminosae seeds of Cassia tora Linn. other families
Cassiaside is a naphthopyrone glucoside, shows mixed-type inhibition against *BACE1* (IC₅₀=4.45 μM; K_i=9.85 μM). Cassiaside possesses potential anti- Alzheimer's disease (AD) activity.

HY-N1255

Scoulerine (-)-Scoulerine; Discretamine	Microtubule/Tubulin Beta-secretase Apoptosis	Alkaloids Isoquinoline Alkaloids Phenols Polyphenols Classification of Application Fields Disease Research Fields Cancer Source classification Plants other families
Scoulerine ((-)-Scoulerine), an isoquinoline alkaloid, is a potent antimitotic compound. Scoulerine is also an inhibitor of *BACE1* (ß-site amyloid precursor protein cleaving enzyme 1). Scoulerine inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells.

HY-108966

Kushenol C	Beta-secretase	Flavonoids Flavonols Phenols Polyphenols Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Leguminosae Sophora flavescens
Kushenol C, isolated from the roots of Sophora flavescens, shows anti-Inflammatory and anti-oxidative stress activities. Kushenol C inhibits BACE1 (β-site APP cleaving enzyme 1) with an IC₅₀ of 5.45 µM.

HY-N0249

Saikosaponin C	Amyloid-β	Terpenoids Triterpenes Source classification Plants Umbelliferae Bupleurum chinensis DC.
Saikosaponin C is a bioactive component found in radix bupleuri, targets amyloid beta and tau in Alzheimer's disease. Saikosaponin C inhibits the secretion of both Aβ1-40 and Aβ1-42, and suppresses abnormal tau phosphorylation, but shows no effect on BACE1 activity and expression.

HY-N3734

Deoxyneocryptotanshinone	Beta-secretase Phosphatase	Terpenoids Diterpenoids Plants Labiatae Hemistepta lyrata
Deoxyneocryptotanshinone, a natural tanshinone, is a high affinity *BACE1* (Beta-secretase) inhibitor with an IC₅₀ value of 11.53 μM. Deoxyneocryptotanshinone shows a promising dose-dependent inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC₅₀ value of 133.5 μM. Deoxyneocryptotanshinone can be used for Alzheimer's disease research.

HY-N2284

Sophoflavescenol	Cholinesterase (ChE) Beta-secretase Phosphodiesterase (PDE)	Flavonols Phenols Polyphenols Flavonoids Disease Research Fields Cancer Classification of Application Fields Source classification Plants Leguminosae Sophora flavescens
Sophoflavescenol is a prenylated flavonol, which shows great inhibitory activity with IC₅₀ of 0.013 μM against Phosphodiesterase 5 (PDE5), and also inhibits RLAR, HRAR, AGE, BACE1, AChE and BChE with IC₅₀s of 0.30 µM, 0.17 µM, 17.89 µg/mL, 10.98 µM, 8.37 µM and 8.21 µM, respectively.

HY-N0226

Epiberberine	Cholinesterase (ChE) Beta-secretase	Isoquinoline Alkaloids Alkaloids Source classification Plants Ranunculaceae Coptis chinensis Franch.
Epiberberine is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive *BACE1* inhibitor, with IC₅₀s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine has antioxidant activity, with peroxynitrite ONOO^- scavenging effect (IC₅₀, 16.83 μM), and can be used for the research of Alzheimer disease. Epiberberine inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways. Epiberberinecan be used for the research of diabetic disease.

HY-N0226A

Epiberberine chloride	Cholinesterase (ChE) Beta-secretase Reactive Oxygen Species	Isoquinoline Alkaloids Alkaloids Neurological Disease Metabolic Disease Disease Research Fields Classification of Application Fields Source classification Plants Ranunculaceae Coptis chinensis Franch.
Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive *BACE1* inhibitor, with IC₅₀s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO^- scavenging effect (IC₅₀, 16.83 μM), and may protect against Alzheimer disease. Epiberberine chloride inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways. Epiberberine has the potential effect in the research of diabetic disease.

Species:	Human (5) Mouse (2)
Tag:	His (3) Tag Free (1) Fc (1)
Source:	HEK293 (7)

Cat. No.	Product Name	Species	Source

HY-P72840

BACE1 Protein, Human (HEK293)
Beta-secretase 1; ASP2; Memapsin-2; BACE1; BACE; KIAA1149
Human HEK293
HY-P72841

BACE1 Protein, Human (HEK293, Fc)
Beta-secretase 1; ASP2; Memapsin-2; BACE1; BACE; KIAA1149
Human HEK293
HY-P72842

BACE1 Protein, Human (HEK293, His)
Beta-secretase 1; ASP2; Memapsin-2; BACE1; BACE; KIAA1149
Human HEK293
HY-P72843

BACE1 Protein, Mouse (HEK293, His)
Beta-secretase 1; ASP2; Memapsin-2; BACE1; BACE; KIAA1149
Mouse HEK293
HY-P77568

BACE-1 Protein, Human (436a.a, HEK293, His)
Beta-secretase 1; ASP2; Asp 2; BACE1; BACE; FLJ90568; HSPC104; KIAA1149; Memapsin-2; BACE-1; EC 3.4.23; EC 3.4.23.46
Human HEK293
HY-P77569

BACE-1 Protein, Human (436a.a, HEK293, Fc)
Beta-secretase 1; ASP2; Asp 2; BACE1; BACE; FLJ90568; HSPC104; KIAA1149; Memapsin-2; BACE-1; EC 3.4.23; EC 3.4.23.46
Human HEK293
HY-P75588

BACE-2 Protein, Mouse (HEK293, His)
Beta-secretase 2; Aspartyl protease 1; ASP1; Memapsin-1; BACE2
Mouse HEK293

BACE

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NaturalProducts

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