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Results for "

BACE-IN-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Beta-secretase (16) Amyloid-β (4) Beta-lactamase (1) Cholinesterase (ChE) (7) Fluorescent Dye (1) Monoamine Oxidase (1) ROS Kinase (2)
By Research Areas:	Inflammation/Immunology (1) Neurological Disease (17)

Inhibitors & Agonists

Peptides

Natural
Products

Targets Recommended: Beta-secretase AIM2 NEKs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-119689

Umibecestat CNP520	Beta-secretase	Neurological Disease
Umibecestat (CNP520) is a beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) inhibitor with IC₅₀s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively ^[1]. Umibecestat can be used for the research of alzheimer's disease.

HY-U00287

*BACE-IN-1*	Beta-secretase	Neurological Disease
BACE-IN-1 (Compound 13) is a substituted lmidazo[1 ,2-a]pyridine derivative which can inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment of diseases in which BACE is involved, such as Alzheimer's disease.

HY-131068

BACE-1 inhibitor 2

Beta-secretase Neurological Disease

BACE-1 inhibitor 2 is a potent and CNS permeable BACE-1 inhibitor with an IC₅₀ of 1.5 nM in BACE-1 enzymatic assay ^[1].
HY-112297

BACE-1 inhibitor 1

Beta-secretase Neurological Disease

BACE-1 inhibitor 1 (Compound 8a) is a potent BACE-1 inhibitor with an IC₅₀ of 56 nM ^[1].
HY-P2714

SEVNLDAEFR

Beta-secretase Neurological Disease

SEVNLDAEFR is a substrate for BACE1 .

BACE-1 inhibitor 2	Beta-secretase	Neurological Disease
BACE-1 inhibitor 2 is a potent and CNS permeable *BACE-1* inhibitor with an IC₅₀ of 1.5 nM in BACE-1 enzymatic assay ^[1].

BACE-1 inhibitor 1	Beta-secretase	Neurological Disease
BACE-1 inhibitor 1 (Compound 8a) is a potent *BACE-1* inhibitor with an IC₅₀ of 56 nM ^[1].

SEVNLDAEFR	Beta-secretase	Neurological Disease
SEVNLDAEFR is a substrate for *BACE1* .

HY-10133

β-Secretase Inhibitor IV	Beta-secretase	Neurological Disease
β-Secretase Inhibitor IV is a potent, cell-active *BACE-1* inhibitor with IC₅₀s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively.

HY-N4186

Glabrolide

Beta-secretase Neurological Disease

Glabrolide, derived from Glycyrrhiza uralensis Fisch., is a β-secretase 1 (BACE-1) inhibitor[1].
HY-160037

SEW06622

Beta-secretase Neurological Disease

SEW06622 is a BACE-1 inhibitor with an IC₅₀ value of 6.3 μM and can be used in Alzheimer's disease research ^[1].

Glabrolide	Beta-secretase	Neurological Disease
Glabrolide, derived from Glycyrrhiza uralensis Fisch., is a β-secretase 1 (BACE-1) inhibitor[1].

SEW06622	Beta-secretase	Neurological Disease
SEW06622 is a *BACE-1* inhibitor with an IC₅₀ value of 6.3 μM and can be used in Alzheimer's disease research ^[1].

HY-P4920

Mca-SEVNLDAEFK(Dnp)-NH2	Fluorescent Dye	Others
Mca-SEVNLDAEFK(Dnp)-NH2 contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl group. It can be used to measure the activities of peptidases that are capable of cleaving an amide bond between the fluorescent group and the quencher group, causing an increase in fluorescence, such as can be used to measure the activity of BACE-1 ^[1].

HY-109055

Elenbecestat E2609	Beta-secretase	Neurological Disease
Elenbecestat (E2609) is a potent, orally bioavailable and CNS-penetrant *BACE-1* inhibitor. Elenbecestat has the potential for Alzheimer's disease (AD) research ^[1] .

HY-124322

NB-360	Beta-secretase	Neurological Disease Inflammation/Immunology
NB-360 is a potent, brain penetrable, and orally bioavailable dual *BACE1/BACE2* inhibitor (IC₅₀: mouse and human BACE1=5 nM; BACE2=6 nM). NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in amyloid precursor protein(APP) transgenic mice. NB-360 can completely block the progression of Aβ deposition in the brains of APP transgenic mice. NB-360 shows excellent selectivity over the related aspartyl proteases pepsin, cathepsin D and cathepsin E ^[1] .

HY-163382

Cbz-Gly-Pro-Ala-O-cinnamyl	Beta-lactamase Cholinesterase (ChE) Amyloid-β	Neurological Disease
Cbz-Gly-Pro-Ala-O-cinnamyl (compound 25) is a small peptide targeting *BACE-1* and AChE with the IC₅₀ values of 0.02 μM and 1 μM, respectively. Cbz-Gly-Pro-Ala-O-cinnamyl shows neuroprotective effect and can be used for study of Alzheimer’s disease ^[1].

HY-122080

Memoquin	Cholinesterase (ChE) Beta-secretase Amyloid-β	Neurological Disease
Memoquin is an anti-amyloid and anti-oxidant multi-target-directed ligand. Memoquin is an orally active inhibitor of *BACE-1* and AChE with IC₅₀ values of 108 and 1.55 nM, respectively. Memoquin is a cognitive enhancer that prevents the Aβ-induced neurotoxicity mediated by oxidative stress. Memoquin can be used for the research of Alzheimer’s disease (AD) ^[1] .

HY-149211

AChE/BChE-IN-12	Cholinesterase (ChE) Beta-secretase Amyloid-β	Neurological Disease
AChE/BChE-IN-12 (compound 10b), a 3,5-dimethoxy analogue, is a potent AChE, BChE, and β-secretase-1 (BACE-1) inhibitor, with IC₅₀ values of 2.57, 3.26, and 10.65 μM, respectively. AChE/BChE-IN-12 crosses the blood-brain barrier via passive diffusion and inhibits the self-aggregation of amyloid-β monomers. AChE/BChE-IN-12 can be used for Alzheimer’s disease (AD) research ^[1].

HY-P4919

Mca-SEVNLDAEFK(Dnp)	Beta-secretase	Others
Mca-SEVNLDAEFK(Dnp) is a Beta-secretase 1 (BACE-1) peptide FRET substrate, containing the 'Swedish' Lys-Met/Asn-Leu mutation of the amyloid precursor protein (APP) β-secretase cleavage site. Cleavage at -Leu-Asp- of Mca-SEVNLDAEFK(Dnp) liberates the highly fluorescent 7-methoxycoumarin (Mca) fragment from the proximity quenching effect of the 2,4-dinitrophenyl (Dnp) internal quencher resulting in a large and easily detectable increase in fluorescence intensity.

HY-155085

hAChE-IN-3	Monoamine Oxidase Amyloid-β Cholinesterase (ChE)	Neurological Disease
hAChE-IN-3 (compounds 5c) is a potent and blood-brain barrier permeable AChE, BuChE， *MAO-B-IN-1* and *BACE-1* inhibitor, with IC₅₀ values of 0.44, 0.08, 5.15 and 0.38 μM, respectively. hAChE-IN-3 has antioxidant activity and metal chelating ability. In addition, hAChE-IN-3 can bind to peripheral anion sites, and affect β amyloid and reduce Alzheimer's-associated neurodegeneration. hAChE-IN-3 has the potential for the research of Alzheimer's disease ^[1].

HY-157527

hAChE-IN-7	Cholinesterase (ChE) Beta-secretase	Neurological Disease
hAChE-IN-7 (compound 5s) is a mixed inhibitor affecting both the catalytic active site (CAS) and peripheral anionic site (PAS) of hAChE. hAChE-IN-7 displays the balanced inhibitory effect on hAChE (IC₅₀=69.8 nM) and hBuChE (IC₅₀=68.0 nM), and exhibits inhibitory activity against β-secretase-1 (BACE-1) (IC₅₀=3.6 μM). hAChE-IN-7 has the potential for Alzheimer's disease (AD) research ^[1].

HY-147659

*AChE/BChE/BACE-1-IN-2*	Cholinesterase (ChE) Beta-secretase ROS Kinase	Neurological Disease
AChE/BChE/BACE-1-IN-2 (Compound 4o) is an orally active inhibitor of AChE, BChE, and *BACE-1* with IC₅₀ values of 0.069, 0.127 and 0.097 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-2 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-2 has remarkable antioxidant potential ^[1].

HY-147658

*AChE/BChE/BACE-1-IN-1*	Cholinesterase (ChE) Beta-secretase ROS Kinase	Neurological Disease
AChE/BChE/BACE-1-IN-1 (Compound 4k) is an orally active inhibitor of AChE, BChE, and *BACE-1* with IC₅₀ values of 0.058, 0.082 and 0.115 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-1 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-1 has remarkable antioxidant potential ^[1].

Mca-SEVNLDAEFK(Dnp)-NH2	Fluorescent Dye	Others
Mca-SEVNLDAEFK(Dnp)-NH2 contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl group. It can be used to measure the activities of peptidases that are capable of cleaving an amide bond between the fluorescent group and the quencher group, causing an increase in fluorescence, such as can be used to measure the activity of BACE-1 ^[1].

SEVNLDAEFR	Beta-secretase	Neurological Disease
SEVNLDAEFR is a substrate for *BACE1* .

Mca-SEVNLDAEFK(Dnp)	Beta-secretase	Others
Mca-SEVNLDAEFK(Dnp) is a Beta-secretase 1 (BACE-1) peptide FRET substrate, containing the 'Swedish' Lys-Met/Asn-Leu mutation of the amyloid precursor protein (APP) β-secretase cleavage site. Cleavage at -Leu-Asp- of Mca-SEVNLDAEFK(Dnp) liberates the highly fluorescent 7-methoxycoumarin (Mca) fragment from the proximity quenching effect of the 2,4-dinitrophenyl (Dnp) internal quencher resulting in a large and easily detectable increase in fluorescence intensity.

Glabrolide	Triterpenes Leguminosae Terpenoids Source classification Plants Glycyrrhiza uralensis Fisch.	Beta-secretase
Glabrolide, derived from Glycyrrhiza uralensis Fisch., is a β-secretase 1 (BACE-1) inhibitor[1].

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BACE-IN-1

Inhibitors & Agonists

Peptides

NaturalProducts

Natural
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