Search Result

Results for "

BH3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (1) Apoptosis (10) Autophagy (5) Bcl-2 Family (30) Bcr-Abl (1) Beta-lactamase (1) Biochemical Assay Reagents (1) E1/E2/E3 Enzyme (1) Isotope-Labeled Compounds (1) MDM-2/p53 (1) Mitochondrial Metabolism (1) Mitophagy (1) mTOR (1) NADPH Oxidase (3) Parasite (2) PKC (2) Src (1)
By Research Areas:	Cancer (27) Infection (2) Inflammation/Immunology (4) Metabolic Disease (2) Neurological Disease (2)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2343

BH3 hydrochloride	Apoptosis	Cancer
BH3 hydrochloride, a BBB penetrated peptide, provoke apoptosis either by direct activation of pro-apoptotic Bax/Bak or by neutralizing anti-apoptotic Bcl-2 proteins (Bcl-2, Bcl-XL, Bcl-w, Mcl-1 and A-1) via their BH3 domian .

HY-100383

BH3I-1 BHI1; BH 3I1	Bcl-2 Family MDM-2/p53 E1/E2/E3 Enzyme	Cancer
BH3I-1 is a Bcl-2 family antagonist, which inhibits the binding of the Bak BH3 peptide to Bcl-xL with a K_i of 2.4±0.2 μM in FP assay. BH3I-1 has a K_d of 5.3 μM against the p53/MDM2 pair.

HY-121934

BH3I-2'

Others Cancer

BH3I-2' is the BH3I-2 analogue. BH3I-2 is a Bcl-2 family inhibitor. BH3I-2' can be used for various studies .
HY-P5341

Bik BH3

Bcl-2 Family Others

Bik BH3 is a biological active peptide. (BH3 domain of BIK)
HY-P5342

Hrk BH3

Bcl-2 Family Others

Hrk BH3 is a biological active peptide. (BH3 domain of Hrk)
HY-P0300

Bak BH3

Bcl-2 Family Cancer

Bak BH3 is derived from the BH3 domain of Bak, can antagonize the function of Bcl-xL in cells.
HY-P5328

Noxa A BH3

NADPH Oxidase Others

Noxa A BH3 is a biological active peptide. (BH3 domain of Noxa protein)
HY-P5330

Noxa B BH3

NADPH Oxidase Others

Noxa B BH3 is a biological active peptide. (BH3 domain of Noxa protein)
HY-P1562

PUMA BH3

Bcl-2 Family Cancer

PUMA BH3 is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide, acts as a direct activator of Bak, with a K_d of 26 nM.
HY-P1562A

PUMA BH3 TFA

Bcl-2 Family Cancer

PUMA BH3 TFA is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide, acts as a direct activator of Bak, with a K_d of 26 nM .

BH3I-2'	Others	Cancer
BH3I-2' is the BH3I-2 analogue. BH3I-2 is a Bcl-2 family inhibitor. BH3I-2' can be used for various studies .

Bik BH3	Bcl-2 Family	Others
Bik BH3 is a biological active peptide. (BH3 domain of BIK)

Hrk BH3	Bcl-2 Family	Others
Hrk BH3 is a biological active peptide. (BH3 domain of Hrk)

Bak BH3	Bcl-2 Family	Cancer
Bak BH3 is derived from the BH3 domain of Bak, can antagonize the function of Bcl-xL in cells.

Noxa A BH3	NADPH Oxidase	Others
Noxa A BH3 is a biological active peptide. (BH3 domain of Noxa protein)

Noxa B BH3	NADPH Oxidase	Others
Noxa B BH3 is a biological active peptide. (BH3 domain of Noxa protein)

PUMA BH3	Bcl-2 Family	Cancer
PUMA BH3 is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide, acts as a direct activator of Bak, with a K_d of 26 nM.

*PUMA BH3* TFA**	Bcl-2 Family	Cancer
PUMA BH3 TFA is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide, acts as a direct activator of Bak, with a K_d of 26 nM .

HY-P5324

*Bad BH3* (mouse)**	Bcl-2 Family	Others
Bad BH3 (mouse) is a biological active peptide. (This is a bcl-2 binding peptide. This peptide is derived from the BH3 domain (a death domain) of Bad, amino acid residues 140 to 165.)

HY-P5327

r8 Bid BH3	Bcl-2 Family	Others
r8 Bid BH3 is a biological active peptide. (The Bid BH3 is a pro-apoptotic member of the 'BH3-only' subset of BCL-2 family proteins that constitute a critical control point in apoptosis. r8BIDBH3 is lethal to human leukemia cell lines that expresse Bcl-2. The Bcl-2 antagonists may have the potential to be efficacious in cancer therapy. Poly-D-arginine (d-isomer as denoted by rrrrrrrr) is fused to the Bid BH3 peptide to facilitate cellular uptake of the peptide.)

HY-P1527

Bim BH3

Bcl-2 Family Others

Bim BH3 is a biological active peptide. (This Bim peptide belongs to the pro-apoptotic Bcl-2 family of proteins.)
HY-P5325F

Bid BH3 (80-99), FAM labeled

Bcl-2 Family Others

Bid BH3 (80-99), FAM labeled is a biological active peptide. (This is a 5-FAM-labeled Bid BH3 HY-P5325 peptide.)

Bim BH3	Bcl-2 Family	Others
Bim BH3 is a biological active peptide. (This Bim peptide belongs to the pro-apoptotic Bcl-2 family of proteins.)

*Bid BH3* (80-99), FAM labeled**	Bcl-2 Family	Others
Bid BH3 (80-99), FAM labeled is a biological active peptide. (This is a 5-FAM-labeled Bid BH3 HY-P5325 peptide.)

HY-P2466

*Bax BH3* peptide (55-74), wild type**	Apoptosis	Cancer
Bax BH3 peptide (55-74), wild type is a 20-amino acid Bax BH3 peptide (Bax 1) capable of inducing apoptosis in a variety of cell line models .

HY-P0300F

Bak BH3 (72-87), TAMRA-labeled

Bcl-2 Family Others

Bak BH3 (72-87), TAMRA-labeled is a biological active peptide.

*Bak BH3* (72-87), TAMRA-labeled**	Bcl-2 Family	Others
Bak BH3 (72-87), TAMRA-labeled is a biological active peptide.

HY-P1889

*Bim BH3, Peptide IV*	Bcl-2 Family	Inflammation/Immunology
Bim BH3, Peptide IV is a 26-residue peptide from BH3-only protein Bim, which belongs to the pro-apoptotic group of the Bcl-2 family of proteins .

HY-P5329

r8-Gly-Noxa A BH3	NADPH Oxidase	Others
r8-Gly-Noxa A BH3 is a biological active peptide. (This cell permeable peptide is derived from the BH3 domain (a death domain) of Noxa A, amino acid residues 17 to 36. Eight D-Arginine residues and a Glycine linker residue are added to the amino terminal of the peptide.)

HY-P1889A

*Bim BH3, Peptide IV TFA*	Bcl-2 Family	Inflammation/Immunology
Bim BH3, Peptide IV TFA is a 26-residue peptide from BH3-only protein Bim, which belongs to the pro-apoptotic group of the Bcl-2 family of proteins .

HY-P5325

*Bid BH3* (80-99)**	Bcl-2 Family	Others
Bid BH3 (80-99) is a biological active peptide. (BID is a pro-apoptotic member of the 'BH3-only' (BOPS) subset of the BCL-2 family of proteins that constitute a critical control point in apoptosis. Bid is the first of the BOPs reported to bind and activate Bcl-2, Bax, and Bak. Bid serves as a death-inducing ligand that moves from the cytosol to the mitochondrial membrane to inactivate Bcl-2 or to activate Bax.Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)

HY-P1733

BMf-BH3 BMF-Y	Apoptosis	Cancer
BMf-BH3 (BMF-Y) belongs to the Bcl-2 apoptosis mediator family. BH3-only protein, Bmf is a key molecule for histone deacetylase (HDAC) inhibitors mediated enhancing effect on ionizing radiation-induced cell death .

HY-109184

Murizatoclax AMG 397	Bcl-2 Family	Cancer
Murizatoclax (AMG 397) is a potent, selective and orally active inhibitor of myeloid leukemia 1 (MCL-1) inhibitor, with a K_i of 15 pM. Murizatoclax competitive binds to the BH3-binding groove of MCL1 with pro-apoptotic BCL-2 family members. Murizatoclax can be used for the research of cancer .

HY-161276

BFC1108	Apoptosis Bcl-2 Family	Cancer
BFC1108 is a small molecule Bcl-2 functional converter. BFC1108 induces a conformational change in Bcl-2, resulting in the exposure of its BH3 domain both in vitro and in vivo. BFC1108 effectively induces apoptosis in Bcl-2 expressing cancers. .

HY-15464D

(S)-Gossypol (acetic acid) 1 Publications Verification (S)-(+)-Gossypol acetic acid	Bcl-2 Family	Cancer
(S)-Gossypol is the isomer of a natural product Gossypol. (S)-Gossypol binds to the BH3-binding groove of Bcl-xL and Bcl-2 proteins with high affinity.

HY-10969

Obatoclax Mesylate 5+ Cited Publications GX15-070 Mesylate	Bcl-2 Family Autophagy Parasite	Infection Cancer
Obatoclax Mesylate (GX15-070 Mesylate), a BH3 mimetic, is a pan-BCL-2 family proteins inhibitor with a K_i of 220 nM for BCL-2 . Obatoclax Mesylate induces autophagy-dependent cell death and targets cyclin D1 for proteasomal degradation. Obatoclax Mesylate has anti-cancer and broad-spectrum antiparasitic activity ^[3] .

HY-10969A

Obatoclax GX15-070	Bcl-2 Family Autophagy Parasite	Infection Cancer
Obatoclax (GX15-070), a BH3 mimetic, is a pan-BCL-2 family proteins inhibitor with a K_i of 220 nM for BCL-2 . Obatoclax induces autophagy-dependent cell death and targets cyclin D1 for proteasomal degradation. Obatoclax has anti-cancer and broad-spectrum antiparasitic activity ^[3] .

HY-161242

CBI1	Bcl-2 Family	Cancer
CBI1 is a covalent BAX inhibitor. CBI1 selectively derivatizes BAX at C126 and inhibits BAX activation by triggering ligands or point mutagenesis. CBI1 blocks t-2-hex lipidation and oligomerization of BAX. CBI1 inhibits BAX activation induced by BH3 ligands, F116A mutagenesis or t-2-hex .

HY-112416

AZD4320 1 Publications Verification	Bcl-2 Family	Cancer
AZD4320 is a novel BH3-mimicking dual BCL2/BCLxL inhibitor with IC₅₀s of 26 nM, 17 nM, and 170 nM for KPUM-MS3, KPUM-UH1, and STR-428 cells, respectively.

HY-50907

ABT-737 Maximum Cited Publications 36 Publications Verification	Bcl-2 Family Apoptosis Autophagy Mitophagy	Cancer
ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-x_L and Bcl-w inhibitor with EC₅₀s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia (AML) research ^[3].

HY-12048

Chelerythrine chloride 10+ Cited Publications	PKC Bcl-2 Family Apoptosis Autophagy	Metabolic Disease Inflammation/Immunology Cancer
Chelerythrine chloride is a potent, cell-permeable inhibitor of protein kinase C, with an IC₅₀ of 660 nM. Chelerythrine chloride inhibits the Bcl-XL-Bak BH3 peptide binding with IC₅₀ of 1.5 μM and displaces Bax from Bcl-XL. Chelerythrine chloride induces apoptosis and autophagy.

HY-P2499

BAD (103-127) (human), FAM-labeled	Bcl-2 Family	Cancer
BAD (103-127) (human), FAM-labeled is a FAM-labeled human BAD (103-127) (HY-P2468). BAD (103-127) (human), the 25-mer Bad peptide, is derived from the BH3 domain of BAD, can antagonize the function of Bcl-xL .

HY-103661

BI-6C9	Mitochondrial Metabolism Apoptosis	Neurological Disease
BI-6C9 is a highly specific BH3 interacting domain (Bid) inhibitor, which prevents mitochondrial outer membrane potential (MOMP) and mitochondrial fission, and protects the cells from mitochondrial apoptosis inducing factor (AIF) release and caspase-independent cell death in neurons .

HY-P2468

BAD (103-127) (human) BADBH3 103-127 (human); BADBH3 (human)	Bcl-2 Family	Cancer
BAD (103-127) (human), the 25-mer Bad peptide, is derived from the BH3 domain of BAD, can antagonize the function of Bcl-xL. BAD (103-127) (human) is reported to have almost 800-fold higher affinity for Bcl-XL than the 16-mer peptide .

HY-18628

UMI-77 1 Publications Verification	Bcl-2 Family	Cancer
UMI-77 is a selective Mcl-1 inhibitor, which shows high binding affinity to Mcl-1 (IC₅₀=0.31 μM). UMI-77 binds to the BH3 binding groove of Mcl-1 with K_i of 490 nM, showing selectivity over other members of anti-apoptotic Bcl-2 members.

HY-N2359

Chelerythrine	Beta-lactamase PKC Bcl-2 Family Apoptosis Autophagy	Metabolic Disease Inflammation/Immunology Cancer
Chelerythrine is a natural alkaloid, acts as a potent and selective Ca ²⁺/phospholopid-dependent PKC antagonist, with an IC₅₀ of 0.7 μM . Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity . Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with IC₅₀ of 1.5 μM and displaces Bax from BclXL. Chelerythrine triggers apoptosis and autophagy ^[3] .

HY-18628S

UMI-77-d4	Isotope-Labeled Compounds Bcl-2 Family	Cancer
UMI-77-d₄ is the deuterium labeled UMI-77. UMI-77 is a selective Mcl-1 inhibitor, which shows high binding affinity to Mcl-1 (IC50=0.31 μM). UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM, showing selectivity over other members of anti-apoptotic Bcl-2 members.

HY-50907S

ABT-737-d8	Biochemical Assay Reagents	Cancer
ABT 737-d₈ is the deuterium labeled ABT-737. ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-x_L and Bcl-w inhibitor with EC₅₀s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia (AML) research ^[3].

HY-15191B

(S)-Sabutoclax (S)-BI-97C1	Bcl-2 Family	Cancer
(S)-Sabutoclax ((S)-BI-97C1), an optically pure apogossypol derivative, is pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. (S)-Sabutoclax (Compound II) inhibits the binding of BH3 peptides to Bcl-XL, Bcl-2, Mcl-1, and Bfl-1 with IC₅₀ values of 0.31, 0.32, 0.20, and 0.62 μM, respectively. (S)-Sabutoclax also potently inhibits cell growth of human prostate cancer, lung cancer, and lymphoma cell lines with EC₅₀ values of 0.13, 0.56, and 0.049 μM, respectively. (S)-Sabutoclax can be used for the research of apoptosis-based therapies against cancer .

HY-50868

Bafetinib 5+ Cited Publications INNO-406; NS-187	Bcr-Abl Src Apoptosis	Cancer
Bafetinib is an orally active Lyn/Bcr-Abl tyrosine kinase inhibitor. Bafetinib enhances the activity of several pro-apoptotic Bcl-2 homology (BH) 3-pure proteins (Bim, Bad, Bmf, and Bik) through intrinsic apoptotic pathways regulated by the Bcl-2 family, and induces apoptosis of Ph ⁺ leukemia cells. Bafetinib has antitumor activity ^[3].

HY-112218

MIK665 5+ Cited Publications S-64315	Bcl-2 Family	Cancer
MIK665 (S-64315), derived from S63845, is a myeloid cell leukemia sequence 1 (MCL1) inhibitor . MIK665 has an IC₅₀ of 1.81 nM for MCL1 .

HY-W058849

MT 63-78	AMPK mTOR Apoptosis	Cancer
MT 63-78 is a specific and potent direct AMPK activator with an EC₅₀ of 25 μM. MT 63–78 also induces cell mitotic arrest and apoptosis. MT 63-78 blocks prostate cancer growth by inhibiting the lipogenesis and mTORC1 pathways. MT 63-78 has antitumor effects .

Cat. No.	Product Name	Target	Research Area

HY-P2343

BH3 hydrochloride	Apoptosis	Cancer
BH3 hydrochloride, a BBB penetrated peptide, provoke apoptosis either by direct activation of pro-apoptotic Bax/Bak or by neutralizing anti-apoptotic Bcl-2 proteins (Bcl-2, Bcl-XL, Bcl-w, Mcl-1 and A-1) via their BH3 domian .

HY-P5341

Bik BH3

Bcl-2 Family Others

Bik BH3 is a biological active peptide. (BH3 domain of BIK)
HY-P5342

Hrk BH3

Bcl-2 Family Others

Hrk BH3 is a biological active peptide. (BH3 domain of Hrk)
HY-P0300

Bak BH3

Bcl-2 Family Cancer

Bak BH3 is derived from the BH3 domain of Bak, can antagonize the function of Bcl-xL in cells.
HY-P5328

Noxa A BH3

NADPH Oxidase Others

Noxa A BH3 is a biological active peptide. (BH3 domain of Noxa protein)
HY-P5330

Noxa B BH3

NADPH Oxidase Others

Noxa B BH3 is a biological active peptide. (BH3 domain of Noxa protein)
HY-P1562

PUMA BH3

Bcl-2 Family Cancer

PUMA BH3 is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide, acts as a direct activator of Bak, with a K_d of 26 nM.
HY-P1562A

PUMA BH3 TFA

Bcl-2 Family Cancer

PUMA BH3 TFA is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide, acts as a direct activator of Bak, with a K_d of 26 nM .

Bik BH3	Bcl-2 Family	Others
Bik BH3 is a biological active peptide. (BH3 domain of BIK)

Hrk BH3	Bcl-2 Family	Others
Hrk BH3 is a biological active peptide. (BH3 domain of Hrk)

Bak BH3	Bcl-2 Family	Cancer
Bak BH3 is derived from the BH3 domain of Bak, can antagonize the function of Bcl-xL in cells.

HY-P5324

*Bad BH3* (mouse)**	Bcl-2 Family	Others
Bad BH3 (mouse) is a biological active peptide. (This is a bcl-2 binding peptide. This peptide is derived from the BH3 domain (a death domain) of Bad, amino acid residues 140 to 165.)

HY-P5327

r8 Bid BH3	Bcl-2 Family	Others
r8 Bid BH3 is a biological active peptide. (The Bid BH3 is a pro-apoptotic member of the 'BH3-only' subset of BCL-2 family proteins that constitute a critical control point in apoptosis. r8BIDBH3 is lethal to human leukemia cell lines that expresse Bcl-2. The Bcl-2 antagonists may have the potential to be efficacious in cancer therapy. Poly-D-arginine (d-isomer as denoted by rrrrrrrr) is fused to the Bid BH3 peptide to facilitate cellular uptake of the peptide.)

HY-P1527

Bim BH3

Bcl-2 Family Others

Bim BH3 is a biological active peptide. (This Bim peptide belongs to the pro-apoptotic Bcl-2 family of proteins.)
HY-P5325F

Bid BH3 (80-99), FAM labeled

Bcl-2 Family Others

Bid BH3 (80-99), FAM labeled is a biological active peptide. (This is a 5-FAM-labeled Bid BH3 HY-P5325 peptide.)

HY-P2342

*Angiopep-Bim BH3* hydrochloride**	Peptides	Neurological Disease
Angiopep-Bim BH3 hydrochloride, a BBB penetrated peptode, could be used to investigate the permeability of CNS therapeutics .

HY-P2466

*Bax BH3* peptide (55-74), wild type**	Apoptosis	Cancer
Bax BH3 peptide (55-74), wild type is a 20-amino acid Bax BH3 peptide (Bax 1) capable of inducing apoptosis in a variety of cell line models .

HY-P0300F

Bak BH3 (72-87), TAMRA-labeled

Bcl-2 Family Others

Bak BH3 (72-87), TAMRA-labeled is a biological active peptide.

HY-P1889

*Bim BH3, Peptide IV*	Bcl-2 Family	Inflammation/Immunology
Bim BH3, Peptide IV is a 26-residue peptide from BH3-only protein Bim, which belongs to the pro-apoptotic group of the Bcl-2 family of proteins .

HY-P5329

r8-Gly-Noxa A BH3	NADPH Oxidase	Others
r8-Gly-Noxa A BH3 is a biological active peptide. (This cell permeable peptide is derived from the BH3 domain (a death domain) of Noxa A, amino acid residues 17 to 36. Eight D-Arginine residues and a Glycine linker residue are added to the amino terminal of the peptide.)

HY-P1889A

*Bim BH3, Peptide IV TFA*	Bcl-2 Family	Inflammation/Immunology
Bim BH3, Peptide IV TFA is a 26-residue peptide from BH3-only protein Bim, which belongs to the pro-apoptotic group of the Bcl-2 family of proteins .

HY-P5325

*Bid BH3* (80-99)**	Bcl-2 Family	Others
Bid BH3 (80-99) is a biological active peptide. (BID is a pro-apoptotic member of the 'BH3-only' (BOPS) subset of the BCL-2 family of proteins that constitute a critical control point in apoptosis. Bid is the first of the BOPs reported to bind and activate Bcl-2, Bax, and Bak. Bid serves as a death-inducing ligand that moves from the cytosol to the mitochondrial membrane to inactivate Bcl-2 or to activate Bax.Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)

HY-P1733

BMf-BH3 BMF-Y	Apoptosis	Cancer
BMf-BH3 (BMF-Y) belongs to the Bcl-2 apoptosis mediator family. BH3-only protein, Bmf is a key molecule for histone deacetylase (HDAC) inhibitors mediated enhancing effect on ionizing radiation-induced cell death .

HY-P2499

BAD (103-127) (human), FAM-labeled	Bcl-2 Family	Cancer
BAD (103-127) (human), FAM-labeled is a FAM-labeled human BAD (103-127) (HY-P2468). BAD (103-127) (human), the 25-mer Bad peptide, is derived from the BH3 domain of BAD, can antagonize the function of Bcl-xL .

HY-P2468

BAD (103-127) (human) BADBH3 103-127 (human); BADBH3 (human)	Bcl-2 Family	Cancer
BAD (103-127) (human), the 25-mer Bad peptide, is derived from the BH3 domain of BAD, can antagonize the function of Bcl-xL. BAD (103-127) (human) is reported to have almost 800-fold higher affinity for Bcl-XL than the 16-mer peptide .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-12048

Chelerythrine chloride 10+ Cited Publications	Alkaloids Structural Classification Classification of Application Fields Chelidonium majus Source classification Metabolic Disease Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Papaveraceae	PKC Bcl-2 Family Apoptosis Autophagy
Chelerythrine chloride is a potent, cell-permeable inhibitor of protein kinase C, with an IC₅₀ of 660 nM. Chelerythrine chloride inhibits the Bcl-XL-Bak BH3 peptide binding with IC₅₀ of 1.5 μM and displaces Bax from Bcl-XL. Chelerythrine chloride induces apoptosis and autophagy.

HY-N2359

Chelerythrine	Alkaloids Structural Classification Classification of Application Fields Source classification Metabolic Disease Macleaya cordata (Willd.) R. Br. Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Papaveraceae	Beta-lactamase PKC Bcl-2 Family Apoptosis Autophagy
Chelerythrine is a natural alkaloid, acts as a potent and selective Ca ²⁺/phospholopid-dependent PKC antagonist, with an IC₅₀ of 0.7 μM . Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity . Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with IC₅₀ of 1.5 μM and displaces Bax from BclXL. Chelerythrine triggers apoptosis and autophagy ^[3] .

Species:	Human (1) Mouse (2)
Tag:	His (2) Tag Free (1) GST (1)
Source:	E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P7662

	BID Protein, Human rHuBID; BH3-Interacting Domain Death Agonist; BID	Human	E. coli
	BID Protein, Human expresses in E. coli. The BH3-only protein BID, a pro-apoptotic member of the Bcl-2 family, was initially discovered through binding to both pro-apoptotic Bax and anti-apoptotic Bcl-2. BID is activated in the BCL-2-regulated or mitochondrial apoptosis pathway and acts as a switch between the extrinsic and intrinsic cell death pathways.

HY-P701328

	BID Protein, Mouse (His) BH3-interacting domain death agonist; BID; p15 BID	Mouse	E. coli
	BID Protein, a pro-apoptotic member of the Bcl-2 family, is initially discovered through binding to both pro-apoptotic Bax and anti-apoptotic Bcl-2. BID is activated in the BCL-2-regulated or mitochondrial apoptosis pathway and acts as a switch between the extrinsic and intrinsic cell death pathways. BID is susceptible to proteolytic cleavage by caspases, calpains, Granzyme B and cathepsins. BID Protein, Mouse (His) is the recombinant mouse-derived BID protein, expressed by E. coli , with C-His labeled tag. The total length of BID Protein, Mouse (His) is 195 a.a., with molecular weight of ~22.72 kDa.

HY-P72852

	BID Protein, Mouse (His-GST) BH3-interacting domain death agonist; BID; p15 BID	Mouse	E. coli
	BID Protein, a pro-apoptotic member of the Bcl-2 family, is initially discovered through binding to both pro-apoptotic Bax and anti-apoptotic Bcl-2. BID is activated in the BCL-2-regulated or mitochondrial apoptosis pathway and acts as a switch between the extrinsic and intrinsic cell death pathways. BID is susceptible to proteolytic cleavage by caspases, calpains, Granzyme B and cathepsins. BID Protein, Mouse (His-GST) is the recombinant mouse-derived BID protein, expressed by E. coli , with N-His, N-GST labeled tag. The total length of BID Protein, Mouse (His-GST) is 195 a.a., with molecular weight of ~48 kDa.

Cat. No.	Product Name	Chemical Structure

HY-50907S

ABT-737-d8

ABT 737-d₈ is the deuterium labeled ABT-737. ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-x_L and Bcl-w inhibitor with EC₅₀s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia (AML) research ^[3].

HY-18628S

UMI-77-d4
UMI-77-d₄ is the deuterium labeled UMI-77. UMI-77 is a selective Mcl-1 inhibitor, which shows high binding affinity to Mcl-1 (IC50=0.31 μM). UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM, showing selectivity over other members of anti-apoptotic Bcl-2 members.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks