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BLZ945

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-12768
    Sotuletinib
    Maximum Cited Publications
    15 Publications Verification

    BLZ945

    		 c-Fms Cancer
    Sotuletinib (BLZ945) is a potent, selective and brain-penetrant CSF-1R (c-Fms) inhibitor with an IC50 of 1 nM, showing more than 1,000-fold selectivity against its closest receptor tyrosine kinase homologs .
    Sotuletinib
  • HY-12768A
    Sotuletinib hydrochloride
    Maximum Cited Publications
    15 Publications Verification

    BLZ945 hydrochloride

    		 c-Fms Cancer
    Sotuletinib (BLZ945) hydrochloride is a potent, selective and brain-penetrant CSF-1R (c-Fms) inhibitor with an IC50 of 1 nM, showing more than 1,000-fold selectivity against its closest receptor tyrosine kinase homologs .
    Sotuletinib hydrochloride
  • HY-12768B
    Sotuletinib dihydrochloride

    BLZ945 dihydrochloride

    		 c-Fms Neurological Disease Cancer
    Sotuletinib (BLZ945) dihydrochloride is an orally active and blood-brain barrier-permeable CSF1-R-specific inhibitor (IC50=1 nM). Sotuletinib (BLZ945) dihydrochloride induces tumor cell apoptosis and effectively inhibits tumor growth in mouse models. Sotuletinib dihydrochloride can be used in cancer and amyotrophic lateral sclerosis (ALS) research .
    Sotuletinib dihydrochloride

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