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Results for "

BMI-1

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

1

Natural
Products

1

Recombinant Proteins

2

Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-103696
    PTC-028

    		Apoptosis Cancer
    PTC-028 is an orally bioavailable inhibitor of stem cell factor BMI-1 in ovarian cancer. PTC-028 selectively inhibits cancer cells whereas normal cells remain unaffected. PTC-028 downregulates BMI-1, inducing caspase-mediated apoptosis [1].
    PTC-028
  • HY-112041
    Unesbulin
    3 Publications Verification

    PTC596

    		 Apoptosis Cancer
    Unesbulin (PTC596) is an orally active and selective B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) inhibitor. Unesbulin downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia (AML) cells. Unesbulin has anti-leukemic activity [1] .
    Unesbulin
  • HY-RS01532
    BMI1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others
    BMI1 Human Pre-designed siRNA Set A contains three designed siRNAs for BMI1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    BMI1 Human Pre-designed siRNA Set A
    BMI1 Human Pre-designed siRNA Set A
  • HY-N0992
    1,6,7-Trihydroxyxanthone

    		Apoptosis Cancer
    1,6,7-Trihydroxyxanthone is a potent anticancer agent. 1,6,7-Trihydroxyxanthone inhibits cell proliferation and induces cell Apoptosis. 1,6,7-Trihydroxyxanthone decreases Bmi-1 expressio and increases the protein levels expression of P14, P16 [1].
    <em>1</em>,6,7-Trihydroxyxanthone
  • HY-143655
    QW24

    		Autophagy Cancer
    QW24 exerts potent anti-tumor activity by down-regulating BMI-1 and is used as an effective therapeutic agent for clinical colorectal cancer research.
    QW24
  • HY-15888
    PTC-209
    Maximum Cited Publications
    10 Publications Verification

    		 Autophagy Cancer
    PTC-209 is a specific BMI-1 inhibitor with an IC50 of 0.5 μM in HEK293T cell line. PTC-209 irreversibly impairs colorectal cancer-initiating cells (CICs). PTC-209 shows potent anti-myeloma activity and impairs the tumor microenvironment [1] .
    PTC-209
  • HY-15888A
    PTC-209 hydrobromide
    Maximum Cited Publications
    10 Publications Verification

    		 Autophagy Cancer
    PTC-209 hydrobromide is a specific BMI-1 inhibitor with an IC50 of 0.5 μM in HEK293T cell line. PTC-209 hydrobromide irreversibly impairs colorectal cancer-initiating cells (CICs). PTC-209 hydrobromide shows potent anti-myeloma activity and impairs the tumor microenvironment [1] .
    PTC-209 hydrobromide
  • HY-143658
    SH498

    		Autophagy Cancer
    SH498, a novel Bmi-1-mediated antitumor agent, shows potent antiproliferative activity.
    SH498
  • HY-139514
    RB-3

    		E1/E2/E3 Enzyme Cancer
    RB-3, a PRC1 inhibitor, binds to RING1B-BMI1f, with a Kd of 2.8 μM [1].
    RB-3

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