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Results for "

BMS-354825

" in MedChemExpress (MCE) Product Catalog:

7

Inhibitors & Agonists

1

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-10181
    Dasatinib
    Maximum Cited Publications
    85 Publications Verification

    BMS-354825

    		 Bcr-Abl Src Autophagy Apoptosis Cancer
    Dasatinib (BMS-354825) is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib inhibits Bcr-Abl and Src with IC50s of <1.0 nM and 0.5 nM, respectively . Dasatinib also induces apoptosis and autophagy.
    Dasatinib
  • HY-10181A
    Dasatinib hydrochloride
    Maximum Cited Publications
    85 Publications Verification

    BMS-354825 hydrochloride

    		 Bcr-Abl Src Autophagy Apoptosis Cancer
    Dasatinib (BMS-354825) hydrochloride is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib hydrochloride inhibits Bcr-Abl and Src with IC50s of <1.0 nM and 0.5 nM, respectively . Dasatinib hydrochloride also induces apoptosis and autophagy.
    Dasatinib hydrochloride
  • HY-10181B
    Dasatinib monohydrate
    Maximum Cited Publications
    85 Publications Verification

    BMS-354825 monohydrate
    Dasatinib (BMS-354825) monohydrate is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib monohydrate inhibits Bcr-Abl and Src with IC50s of <1.0 nM and 0.5 nM, respectively . Dasatinib monohydrate also induces apoptosis and autophagy.
    Dasatinib monohydrate
  • HY-111857
    Dasatinib carbaldehyde

    BMS-354825 carbaldehyde; PROTAC ABL binding moiety 4

    		 Ligands for Target Protein for PROTAC Cancer
    Dasatinib carbaldehyde (BMS-354825 carbaldehyde), the Dasatinib (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER .
    Dasatinib carbaldehyde
  • HY-10181S
    Dasatinib-d8

    BMS-354825-d8
    Dasatinib-d8 is a deuterium labeled Dasatinib. Dasatinib is a dual Bcr-Abl and Src family tyrosine kinase inhibitor.
    Dasatinib-d8
  • HY-107447
    N-Deshydroxyethyl Dasatinib

    N-Deshydroxyethyl BMS-354825

    		 Drug Metabolite Inflammation/Immunology Cancer
    N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825) is a metabolite of Dasatinib, Dasatinib is a multi-kinase inhibitor that potently inhibits Bcr-Abl, Src family and platelet-derived growth factor receptor kinases. N-Deshydroxyethyl Dasatinib can be used in cancer and immune disease research .
    N-Deshydroxyethyl Dasatinib
  • HY-107447S
    N-Deshydroxyethyl Dasatinib-d8

    		Isotope-Labeled Compounds Ligands for Target Protein for PROTAC Cancer
    N-Deshydroxyethyl Dasatinib-d8 is the deuterium labeled N-Deshydroxyethyl Dasatinib. N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825), the Dasatinib-based moiety, binds to IAP ligand via a linker to form SNIPER to degrade ABL[1].
    N-Deshydroxyethyl Dasatinib-d8

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