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BRD4

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By Targets:	ADC Cytotoxin (1) Androgen Receptor (1) Apoptosis (26) Autophagy (3) Bcl-2 Family (1) c-Myc (3) Casein Kinase (1) Caspase (2) CDK (1) DNA-PK (1) DNA/RNA Synthesis (2) E3 Ligase Ligand-Linker Conjugates (4) Epigenetic Reader Domain (204) ERK (3) FKBP (2) HDAC (3) Histone Acetyltransferase (8) Histone Methyltransferase (1) HIV (4) JAK (1) Ligands for E3 Ligase (1) Ligands for Target Protein for PROTAC (9) Molecular Glues (1) p38 MAPK (1) Parasite (1) PARP (2) PD-1/PD-L1 (1) PI3K (3) Polo-like Kinase (PLK) (3) PROTAC Linkers (3) PROTAC-Linker Conjugates for PAC (2) PROTACs (59) Small Interfering RNA (siRNA) (3) SNIPERs (1) Src (1) Target Protein Ligand-Linker Conjugates (3)
By Research Areas:	Cancer (211) Cardiovascular Disease (3) Infection (7) Inflammation/Immunology (25) Metabolic Disease (2) Neurological Disease (1)
Click Chemistry:	PROTAC Synthesis (2) Azide (5) Alkynes (1)

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Click Chemistry

Cat. No.	Compare	Product Name	Species	Source

	BRD4 Protein, Human (His-Flag) 1 Publications Verification rHuBromodomain-containing protein 4/BRD4, His-Flag; HUNK1; HUNK1bromodomain-containing protein 4; HUNKI; MCAP	Human	E. coli
	The BRD4 protein is a chromatin reader that recognizes and binds acetylated histones, transmits epigenetic memory and regulates transcription during cell division. It associates with acetylated chromatin throughout the cell cycle, maintaining chromatin structure and contributing to epigenetic memory. BRD4 Protein, Human (His-Flag) is the recombinant human-derived BRD4 protein, expressed by E. coli , with N-10*His, N-Flag labeled tag. The total length of BRD4 Protein, Human (His-Flag) is 412 a.a., with molecular weight of 55-60 kDa.

Cat. No.	Product Name	Application	Reactivity

BRD4 Antibody BRD4; CAP; HUNK1; MCAP; Bromodomain containing 4; chromosome associated protein	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
BRD4 Antibody is an antibody about 152 kDa, targeting to BRD4.

Cat. No.	Product Name		Classification

*PROTAC BRD4* Degrader-5-CO-PEG3-N3**		Azide
PROTAC BRD4 Degrader-5-CO-PEG3-N3 (Compound 2) is a PROTAC-linker Conjugate for PAC, comprises the BRD4 degrader GNE-987 and PEG-based linker . PROTAC BRD4 Degrader-5-CO-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

*PROTAC BRD4-binding moiety 1*		Alkynes
PROTAC BRD4-binding moiety 1 is a ligand for BRD4. PROTAC BRD4-binding moiety 1 binds to cereblon ligand via a linker to form PROTAC to degrade BRD4 (HY-133136) . PROTAC BRD4-binding moiety 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Lenalidomide-PEG1-azide		Azide
Lenalidomide-PEG1-azide is a E3 ligase lgand-linker conjugate. Lenalidomide-PEG1-azide incorporates the Lenalidomide based cereblon ligand and a linker.?Lenalidomide-PEG1-azide?can be used to design a PROTAC BRD4 Degrader-2 (HY-133136) . Lenalidomide-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

Pomalidomide-PEG1-azide		Azide
Pomalidomide-PEG1-azide is a E3 ligase lgand-linker conjugate. Pomalidomide-PEG1-azide incorporates the Pomalidomide based cereblon ligand and a linker.?Pomalidomide-PEG1-azide?can be used to design a?PROTAC BRD4 Degrader-1 (HY-133131) . Pomalidomide-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

Azido-PEG1-CH2CO2H		Azide PROTAC Synthesis
Azido-PEG1-CH2CO2H is a PROTAC linker, which refers to the alkyl/ether composition. Azido-PEG1-CH2CO2H can be used in the synthesis of PROTAC BRD4 Degrader-1 . Azido-PEG1-CH2CO2H is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

Azido-PEG1-CH2COO-Cl		PROTAC Synthesis Azide
Azido-PEG1-CH2COO-Cl (compound 43a) is an alkyl/ether-based PROTAC linker. Azido-PEG1-CH2COO-Cl can be used in the synthesis of PROTAC BRD4 Degrader-1 (HY-133131) . Azido-PEG1-CH2COO-Cl is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

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