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Results for "

BRPF1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Epigenetic Reader Domain (11) HDAC (2) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (12)

Inhibitors & Agonists

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-RS01628

BRPF1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
BRPF1 Human Pre-designed siRNA Set A contains three designed siRNAs for BRPF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BRPF1 Human Pre-designed siRNA Set A BRPF1 Human Pre-designed siRNA Set A

HY-RS01629

Brpf1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Brpf1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Brpf1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Brpf1 Mouse Pre-designed siRNA Set A Brpf1 Mouse Pre-designed siRNA Set A

HY-RS01630

Brpf1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Brpf1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Brpf1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Brpf1 Rat Pre-designed siRNA Set A Brpf1 Rat Pre-designed siRNA Set A

HY-151366

*HDAC8/BRPF1-IN-1*	HDAC Epigenetic Reader Domain	Cancer
HDAC8/BRPF1-IN-1 (Compound 23a) is a dual inhibitor of HDAC8 and *BRPF1* with an IC₅₀ of 443 nM against human HDAC8 and a K_d of 67 nM against human BRPF1. HDAC8/BRPF1-IN-1 shows low in vitro activity against HDAC1 and 6 ^[1].

HY-151364

*HDAC6/8/BRPF1-IN-1*	HDAC	Cancer
HDAC6/8/BRPF1-IN-1 is a dual inhibitor of both HDAC6/8 and the bromodomain and PHD finger containing protein 1 (BRPF1). HDAC6/8/BRPF1-IN-1 has inhibitory activity for HDAC1, HDAC6 and HDAC8 with IC₅₀ values of 797 nM, 344 nM and 908 nM, respectively. HDAC6/8/BRPF1-IN-1 has inhibitory activity for BRPF1 with an K_d value of 175.2 nM. HDAC6/8/BRPF1-IN-1 can be used for the research of cancer ^[1].

HY-143332

*TRIM24/BRPF1-IN-2*	Epigenetic Reader Domain	Cancer
TRIM24/BRPF1-IN-2 (compound 20l) is a potent *TRIM24/BRPF1* dual inhibitor, with IC₅₀ values of 0.98 and 1.16 μM, respectively. TRIM24/BRPF1-IN-2 shows TRIM24/BRPF1 bromodomain binding affinity. TRIM24/BRPF1-IN-2 can be used for prostate cancer research ^[1].

HY-18665

GSK-5959

Epigenetic Reader Domain Cancer

GSK-5959 is a potent, selective and cell permeable BRPF1 bromodomain inhibitor with an IC₅₀ of ~ 80 nM ^[1].

GSK-5959	Epigenetic Reader Domain	Cancer
GSK-5959 is a potent, selective and cell permeable *BRPF1* bromodomain inhibitor with an IC₅₀ of ~ 80 nM ^[1].

HY-102000

IACS-9571 ASIS-P040	Epigenetic Reader Domain	Cancer
IACS-9571 is a potent and selective inhibitor of TRIM24 and *BRPF1, with IC₅₀* of 8 nM for TRIM24, and K_ds of 31 nM and 14 nM for TRIM24 and BRPF1, respectively.

HY-102000B

IACS-9571 hydrochloride ASIS-P040 hydrochloride	Epigenetic Reader Domain	Cancer
IACS-9571 (ASIS-P040) hydrochloride is a potent and selective inhibitor of TRIM24 and *BRPF1, with an IC₅₀* of 8 nM for TRIM24, and K_ds of 31 nM and 14 nM for TRIM24 and BRPF1, respectively ^[1].

HY-100220

GSK6853

Epigenetic Reader Domain Cancer

GSK6853 is a potent and selective inhibitor of the BRPF1 bromodomain.

GSK6853	Epigenetic Reader Domain	Cancer
GSK6853 is a potent and selective inhibitor of the *BRPF1* bromodomain.

HY-18664

PFI-4 1 Publications Verification	Epigenetic Reader Domain	Cancer
PFI-4 (compound 11) is a potent and highly selective **BRPF1 Bromodomain (BRPF1B) inhibitor, with an IC₅₀ of 172 nM. PFI-4 can be used to explore the functional mechanisms of the HBO1/BRPF1** complex and to study bone loss and osteolytic malignant bone lesions ^[1] .

HY-101121

NI-42
NI-42 (compound 13-d), a structurally orthogonal chemical probe for the BRPFs, is a biased, potent inhibitor of the BRD of the BRPFs (IC₅₀s of BRPF1/2/3=7.9/48/260 nM; K_ds of BRPF1/2/3=40/210/940 nM) with excellent selectivity over nonclass IV BRD proteins ^[1].

HY-19537

NI-57
NI-57 is an inhibitor of bromodomain and plant homeodomain finger-containing (BRPF) famlily of proteins, with IC₅₀s of 3.1, 46 and 140 nM for BRPF1, BRPF2 (BRD1) and BRPF3, respectively.

HY-100729

GSK9311	Epigenetic Reader Domain	Cancer
GSK9311, a less active analogue of GSK6853, can be used as a negative control. GSK9311 inhibits BRPF bromodomain with pIC₅₀ values of 6.0 and 4.3 for BRPF1 and BRPF2, respectively ^[1].

HY-100729A

GSK9311 hydrochloride	Epigenetic Reader Domain	Cancer
GSK9311 hydrochloride, a less active analogue of GSK6853, can be used as a negative control. GSK9311 hydrochloride inhibits BRPF bromodomain with pIC₅₀ values of 6.0 and 4.3 for BRPF1 and BRPF2, respectively ^[1].

HY-12518

OF-1 3 Publications Verification	Epigenetic Reader Domain	Cancer
OF-1 is a potent pan-BRPF bromodomain (BRD) inhibitor, with IC₅₀ values of 270 nM, 1.2 μM for TRIM24 and BRPF1B, respectively ^[1] .

HY-149806

Bromodomain IN-2	Epigenetic Reader Domain	Cancer
BD-IN-1 is a pan bromodomain (BD) inhibitor with K_D values of 250, 420, 130, 430, 67, 240, 970 nM for BRD4(1), CBP, BRPF1B, BRD7, BRD9, BRDT(1), CECR2 respectively. BD-IN-1 shows antiproliferative activity ^[1].

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P702191

	BRPF1 Protein, Human BRPF1; Peregrin; Bromodomain and PHD finger-containing protein 1; Protein Br140	Human	E. coli
	The BRPF1 protein is a key scaffold in HAT complexes such as MOZ/MORF and HBO1, and has histone H3 acetyltransferase activity. In the HBO1 complex, BRPF1 directs the specificity of KAT7/HBO1 for H3K14ac. BRPF1 Protein, Human is the recombinant human-derived BRPF1 protein, expressed by E. coli , with tag free. The total length of BRPF1 Protein, Human is 129 a.a., .

HY-P702192

	BRPF1 Protein, Human (His) BRPF1; Peregrin; Bromodomain and PHD finger-containing protein 1; Protein Br140	Human	E. coli
	The BRPF1 protein is a key scaffold in HAT complexes such as MOZ/MORF and HBO1, and has histone H3 acetyltransferase activity. In the HBO1 complex, BRPF1 directs the specificity of KAT7/HBO1 for H3K14ac. BRPF1 Protein, Human (His) is the recombinant human-derived BRPF1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of BRPF1 Protein, Human (His) is 129 a.a., .


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