From 11:00 pm to 12:00 pm EST ( 8:00 pm to 9:00 pm PST ) on January 6th, the website will be under maintenance. We are sorry for the inconvenience. Please arrange your schedule properly.
Subtilisin (Compound proteinase) (EC 3.4.21.62) is a proteolytic enzyme, isolated from Bacillus licheniformis. Subtilisin (Compound proteinase) has catalytic activity in anhydrous dimethyl formamide. Subtilisin (Compound proteinase) can be used as a catalyst for easy coupling between sugars and amino acids .
Sarcosine oxidase, Bacillus (SAO) can catalyze the oxidative demethylation of sarcosine to generate glycine, H2O2, 5,10-CH2-tetrahydrofolate, which are often used in biochemical reactions .
Xanthan lyase, a member of polysaccharide lyase family 8, is a key enzyme for complete depolymerization of a bacterial heteropolysaccharide, xanthan, in Bacillus sp. GL1 .
Massarigenin C is a compound that can be isolated from Massarina tunicata. Massarigenin C has inhibitory activity against Bacillus subtilis (ATCC 6051) .
Ziapin 2 is a molecular optomechanical light transducer. Ziapin 2 is an amphiphilic azobenzene with a strong non-covalent affinity to the plasma membrane. Ziapin 2 can be used to photo-modulate the membrane potential in cells of the Gram-positive bacterium Bacillus subtilis. Ziapin 2 enters the lipid membrane very rapidly (≈ 40 ns) .
Talaroderxine D (compound 4) has biofilm inhibitory effect. Talaroderxine D shows antimicrobial activities against Bacillus subtilis and Staphylococcus aureus with MIC values of 2.1 and 8.3 μg/mL .
Bombinin H7 is an antimicrobial peptide derived from skin secretions of Bombina. Bombinin H7 is active against Bacillus megaterium Bm11 with a lethal concentration of 25.2 μM .
Baceridin is a proteasome inhibitor and a cyclic hexapeptide. Baceridin can be isolated from the culture medium of Epiphytic Bacillus. Baceridin can inhibit cell cycle progression and induce tumor cell apoptosis through a p53-independent pathway. Baceridin can be used in cancer research .
5′-Deoxythymidine is a thymidine form which 5' position replaced with hydrogen. 5'-deoxy Thymidine is effective against Bacillus subtilis and Staphylococcus aureus. 5′-Deoxythymidine can be used as a research tool for antiviral and anticancer studies .
Maximin 15 is an antimicrobial peptide derived from the toad brain. Maximin 15 is active against Staphylococcus aureus, Escherichia coli and Bacillus subtilis, with MIC values of 9.4, 18.8, 75 μg/mL, respectively .
Maximin 28 is an antimicrobial peptide derived from the toad brain. Maximin 28 is active against Staphylococcus aureus, Escherichia coli and Bacillus subtilis, with MIC values of 4.7, 9.4, 75 μg/mL, respectively .
SF-C5-TPP is an potent mitochondria-targeted protonophoric uncoupler. SF-C5-TPP has significant proton transfer activity on model planar bilayer lipid membranes. SF-C5-TPP inhibits the growth of Bacillus subtilis with a MIC of 2 μM >[1].
Dalbavancin hydrochloride (MDL-63397 hydrochloride) is a semisynthetic lipoglycopeptide antibiotic with potent bactericidal activity against Gram-positive bacteria. Dalbavancin hydrochloride inhibits Staphylococcus aureus and Bacillus anthracis with MIC90s of 0.06 μg/mL and 0.25 μg/mL, respectively .
γ-Glu-Phe (γ-Glutamylphenylalanine) is synthesized by Bacillus amyloliquefaciens (GBA) and Aspergillus oryzae (GAO). γ-Glu-Phe or the post-enzymatic reaction mixture enhances the umami intensity of commercial soy sauce and model chicken broth .
Dalbavancin (MDL-63397) is a semisynthetic lipoglycopeptide antibiotic with potent bactericidal activity against Gram-positive bacteria. Dalbavancin inhibits Staphylococcus aureus and Bacillus anthracis with MIC90s of 0.06 μg/mL and 0.25 μg/mL, respectively .
Bsu DNA polymerase, Large fragment is a polymerase derived from Bacillus subtilis. Bsu DNA polymerase, Large fragment is a DNA isothermal amplification polymerase with chain replacement activity, which used in RPA recombinase polymerase amplification technology .
γ-Glu-Phe TFA (γ-Glutamylphenylalanine TFA) is synthesized by Bacillus amyloliquefaciens (GBA) and Aspergillus oryzae (GAO). γ-Glu-Phe TFA or the post-enzymatic reaction mixture enhances the umami intensity of commercial soy sauce and model chicken broth .
Kumbicin C is a bis-indolyl benzenoid compound from an Australian soil fungus, Aspergillus kumbius. Kumbicin C inhibits the growth of mouse myeloma cells and the Gram-positive bacterium Bacillus subtilis .
Pulcherriminic acid is a cyclic dipeptide antimicrobial agent with high affinity for Fe 3+, found mainly in Bacillus and yeast. Pulcherriminic acid chelates iron ions through a non-enzymatic reaction to form the extracellular red pigment pulcherrimin, which competes for iron nutrition and thus achieves an antibacterial effect. Pulcherriminic acid has great applications in food, agriculture and medical industries .
Globulol, antimicrobial sesquiterpene, is a natural product with antimicrobial activity. Globulol can be isolated from the fruits of Eucalyptus globulus Labill. Globulol shows antimicrobial activity against Xanthomonas vesicatoria and Bacillus subtilis, the IC50 value of 158.0 μg/mL and 737.2 μg/mL, respectively .
Bipolaricin R (Compound 6) is a compound that can be isolated from Bipolaris maydis. Bipolaricin R exhibits noticeable antimicrobial ability against Bacillus cereus, Staphylococcus aureus, and Staphylococcus epidermidis. Bipolaricin R has excellent antiproliferation and apoptosis induction effects against A549 cell line .
Raxibacumab (ABthrax) is a human IgG1 monoclonal antibody against Bacillus anthracis protective antigen (PA). Raxibacumab blocks the toxin’s deleterious effects by preventing binding of the protective antigen component of the anthrax toxin to its receptors in host cells, thereby blocking the toxin’s deleterious effects. Raxibacumab can be used for anti-anthrax research .
MraY-IN-1 (compound 12a) is a potent MraY inhibitor with an IC50 value of 140 μM. MraY-IN-1 has antimicrobial activity against Escherichia coli K12, Bacillus subtilis W23 and Pseudomonas fluorescens Pf-5 with MIC50s of 7 µg/mL, 12 µg/mL and 46 µg/mL, respectively. MraY-IN-1 can be used for researching anti-bacteria .
N-Acetyl-DL-serine is a hydrophobic amino acid that is synthesized in the body and can be found as a free form or as a salt with malonate, phosphate, or acetate. N-Acetyl-DL-serine has antimicrobial activity against Bacillus cereus and Staphylococcus aureus. N-Acetyl-DL-serine has also been used for the immobilization of DNA fragments on solid surfaces and can be used for protein synthesis and optical detection of DNA strands .
Cyclo(L-Trp-L-Trp) is an antibiotic, and shows antimicrobial activity. Cyclo(L-Trp-L-Trp) can inhibit A. baumannii, as well as Candida albicans, Bacillus subtilis, Micrococcus luteus, Saccharomyces cerevisiae, Aspergillus niger, Staphylococcus aureus. Cyclo(L-Trp-L-Trp) can be used in microbial infection research .
4-Ethoxyphenol is a natural compound isolated from marine gorgonian-associated bacterium Bacillus amyloliquefaciens SCSIO 00856. 4-Ethoxyphenol shows potent antilarval activity towards Bacillus amphitrite larvae with an EC50 value of 24.1 μg/mL .
N2-Acetylguanine is a C2-modified guanine. N2-Acetylguanine binds GR (guanine-guanine riboswitch) with an Kd value of 300 nM. N2-Acetylguanine modulate transcriptional termination. N2-Acetylguanine has the potential for the research of antimicrobial agent .
Pycnophorin significantly inhibits the growth of Bacillus subtilis and Staphyloccocus aureus with equal minimum inhibitory concentration (MIC) values of 25 μM.
Monascorubrin is purified from the mycelium of Monascus purpureus. Monascorubrin has significant antibiotic activities against Bacillus subtilis and Candida pseudotropicalis .
Betonicine (Achilleine), an alkaloid, has cell protectant activity. Betonicine protects Bacillus subtilis against extremes in osmolarity and growth temperatures .
Macatrichocarpin A is a flavanone with anti-bacterial activity. Macatrichocarpin A inhibits Bacillus subtilis with MIC value of 26.5 μM. Macatrichocarpin A can be isolated from the leaves of Macaranga trichocarpa .
Fraxidin is a class of coumarin isolated from the roots of Jatropha podagrica, exhibits antibacterial activity against Bacillus subtilis with an inhibition zone of 12 mm at a concentration of 20 µg/disk .
(1R)-α-Pinene is a volatile monoterpene with antimicrobial activities. (1R)-α-Pinene reduces Bacillus cereus population growth, and exhibits repellent effects .
9-(4′-Hydroxyphenyl)-2-methoxyphenalen-1-one is a phytoalexin and mixed competitive α-glucosidase inhibitor of Bacillus stearothermophilus (IC50: 3.86 mg/L) .
Asperglaucin A represents an unusual phthalide-like derivative. Asperglaucin A exhibits potent antibacterial activities against two plant pathogens Pseudomonas syringae pv actinidae (Psa) and Bacillus cereus, with an MIC value of 6.25 μM .
Monocerin is an isocoumarin derivative. Monocerin is isolated from Microdochium bolleyi, an endophytic fungus from Fagonia cretica. Monocerin shows good antifungal, antibacterial, and antialgal activities against Microbotryum violaceum, Escherichia coli, Bacillus megaterium, and Chlorella fusca .
Reutericyclin (Reutericycline), a unique tetramic acid, is an antibiotic produced by some strains of Lactobacillus reuteri. Reutericyclin (Reutericycline) exhibits a broad inhibitory spectrum including Lactobacillus spp., Bacillus subtilis, B. cereus, Enterococcus faecalis, Staphylococcus aureus, and Listeria innocua .
Tyrothricin is a polypeptide antibiotic mixture isolated from Bacillus brevis and consists of tyrocidines and gramicidins. Tyrothricin shows activity against bacteria, fungi and some viruses. Tyrothricin containing formulations are used in sore throat agents and in agents for the healing of infected superficial and small-area wounds .
Leucine dehydrogenase, Microorganism (EC 1.4.1.9) can be purified from Bacillus spheroides. Leucine dehydrogenase catalyzed the oxidative deamination of L-leucine, L-valine, L-isoleucine, L-norvaline, L-alpha-aminobutyrate, and L-norleucine, and the reductive amination of their keto analogues .
Asperglaucin B is an alkylated salicylaldehyde derivative from the fungus Aspergillus chevalieri SQ-8, with antibacterial activities. Asperglaucin B displays potent antibacterial activities against two plant pathogens Pseudomonas syringae pv actinidae (Psa) and Bacillus cereus, with an MIC value of 6.25 μM .
Blepharotriol is a phenolic triterpene that can be found in Maytenus blepharodes. Blepharotriol shows antimicrobial activity with a MIC value of 8-4 µg/ml for Bacillus subtilis. Blepharotriol shows cytotoxic activity with IC50s of 12.2, >20, >20 µM for HeLa, Hep-2, Vero cells, respectively .
Enfumafungin, a triterpene glycoside, is isolated from extracts derived from fungus Hormonema carpetanum. Enfumafungin is an antifungal compound that is acting on the fungal cell wall, as the (1,3)-beta-D-glucan synthase inhibitor. Enfumafungin is specific for yeasts and fungi (excluding Cryptococcus) and does not inhibit the growth of Bacillus subtilis .
Macrocarpal A (10-epi-Eucarobustol F) is an antibacterial agent, which can be isolated from the leaves of Eucalyptus macrocarpa. Macrocarpal A inhibits the growth of Bacillus subtilis PCI219 (minimum inhibitory concentration below 0.2 µM) and Staphylococcus aureus FDA209P (minimum inhibitory concentration is 0.4 µM) .
3-Methoxybenzamide (3-MBA), an inhibitor of ADP-ribosyltransferase (ADPRTs) and PARP, inhibits cell division in Bacillus subtilis, leading to filamentation and eventually lysis of cells . 3-Methoxybenzamide (3-MBA) enhances in vitro plant growth, microtuberization, and transformation efficiency of blue potato (Solanum tuberosum L. subsp. andigenum) .
Dalbavancin-d6 is the deuterium labeled Dalbavancin[1]. Dalbavancin (MDL-63397) is a semisynthetic lipoglycopeptide antibiotic with potent bactericidal activity against Gram-positive bacteria. Dalbavancin inhibits Staphylococcus aureus and Bacillus anthracis with MIC90s of 0.06 μg/mL and 0.25 μg/mL, respectively[2][3].
(R)-4-Methoxydalbergione is a urease inhibitor with IC50s of 59.72 and 67.33 μM for Bacillus pasteurii urease and Jack bean urease. (R)-4-Methoxydalbergione also has antiplasmodial activity. (R)-4-Methoxydalbergione can be isolated from Ranunculus repens .
Maximin H2 is an antimicrobial peptide derived from the skin secretions of Chinese red belly toad Bombina maxima. Maximin H2 has activity against Escherichia coli ATCC25922, Staphylococcus aureus ATCC2592, Bacillus pyocyaneus CMCCB1010 and Candida albicans ATCC2002, the MIC values are 20, 2, 4, 2 μg/ml, respectively .
Maximin H3 is an antimicrobial peptide derived from the skin secretions of Chinese red belly toad Bombina maxima. Maximin H3 has activity against Escherichia coli ATCC25922, Staphylococcus aureus ATCC2592, Bacillus pyocyaneus CMCCB1010 and Candida albicans ATCC2002, the MIC values are 20, 10, 20, 5 μg/ml, respectively .
Maximin H4 is an antimicrobial peptide derived from the skin secretions of Chinese red belly toad Bombina maxima. Maximin H4 has activity against Escherichia coli ATCC25922, Staphylococcus aureus ATCC2592, Bacillus pyocyaneus CMCCB1010 and Candida albicans ATCC2002, the MIC values are 12, 6, 12, 6 μg/ml, respectively .
Maximin H1 is an antimicrobial peptide derived from the skin secretions of Chinese red belly toad Bombina maxima. Maximin H1 has activity against Escherichia coli ATCC25922, Staphylococcus aureus ATCC2592, Bacillus pyocyaneus CMCCB1010 and Candida albicans ATCC2002, the MIC values are 9, 4.5, 9, 4.5 μg/ml, respectively .
Maximin 31 is an antimicrobial peptide derived from the toad brain. Maximin 31 is active against Staphylococcus aureus and Escherichia coli, with MIC values of 37.5, 75 μg/mL, respectively .
Maximin 32 is an antimicrobial peptide derived from the toad brain. Maximin 32 is active against Staphylococcus aureus and Escherichia coli, with MIC values of 9.4, 18.8 μg/mL, respectively .
Maximin 39 is an antimicrobial peptide derived from the toad brain. Maximin 39 is active against Staphylococcus aureus and Escherichia coli, with MIC values of 18.8, 37.5 μg/mL, respectively .
PD98059 is a potent and selective MEK inhibitor with an IC50 of 5 µM. PD98059 binds to the inactive form of MEK, thereby preventing the activation of MEK1 (IC50 of 2-7 µM) and MEK2 (IC50 of 50 µM) by upstream kinases. PD98059 is a ERK1/2 signaling inhibitor. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR), and suppresses TCDD binding (IC50 of 4 μM) and AHR transformation (IC50 of 1 μM). PD98059 also inhibits Mycobacterium bovisBacillus CalmetteGuerin (BCG)-induced autophagy .
Micronomicin sulfate (Gentamicin C2b sulfate) is an aminoglycoside antibiotic isolated from Micromonospora. Micronomicin sulfate is a broad-spectrum antibiotic close to the gentamicin-type antibiotics, exhibits a high activity against Pseudomonas, Proteus, Klebsiella pneumoniae, Serratia, etc (MIC=0.001-8.3 μg/ml) .
Cellooctaose is an oligosaccharide, consisting of eight glucose residues. Cellooctaose is a low-cost polysaccharides in fermentation to hold on Lactococcus lactis recombinant strain growth. Cellooctaose is the substrate of beta-glucosidase (E.C. 3.2.1.21) .
(9Z)-9,17-Octadecadiene-12,14-diyne-1,11,16-triol is a nature product that could be isolated from the ethyl acetate extract of Cassonia barteri (Araliaceae) leaves. (9Z)-9,17-Octadecadiene-12,14-diyne-1,11,16-triol has antibacterial activity against Bacillus subtilis and Pseudomonas fluorescens, antifungal activity against Cladosporium cucumerinum, moiluscicidal activity against Biomphalaria glabrata . (9Z)-9,17-Octadecadiene-12,14-diyne-1,11,16-triol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Casein Agar can be used for casein decomposition test of Bacillus cereus. The composition of 1 liter of Casein Agar contains contains: 10.0 g casein, 3.0 g beef infusion powder, 5.0 g sodium chloride, 2.0 g dipotassium hydrogen phosphate and 15.0 g agar .
Gageotetrin C is an antimicrobial peptide derived from the marine bacterium Bacillus subtilis. Gageotetrin C is more active against fungi (MIC value is 0.02-0.04 μM) .
Bombinin H7 is an antimicrobial peptide derived from skin secretions of Bombina. Bombinin H7 is active against Bacillus megaterium Bm11 with a lethal concentration of 25.2 μM .
Baceridin is a proteasome inhibitor and a cyclic hexapeptide. Baceridin can be isolated from the culture medium of Epiphytic Bacillus. Baceridin can inhibit cell cycle progression and induce tumor cell apoptosis through a p53-independent pathway. Baceridin can be used in cancer research .
Maximin 15 is an antimicrobial peptide derived from the toad brain. Maximin 15 is active against Staphylococcus aureus, Escherichia coli and Bacillus subtilis, with MIC values of 9.4, 18.8, 75 μg/mL, respectively .
Maximin 28 is an antimicrobial peptide derived from the toad brain. Maximin 28 is active against Staphylococcus aureus, Escherichia coli and Bacillus subtilis, with MIC values of 4.7, 9.4, 75 μg/mL, respectively .
γ-Glu-Phe (γ-Glutamylphenylalanine) is synthesized by Bacillus amyloliquefaciens (GBA) and Aspergillus oryzae (GAO). γ-Glu-Phe or the post-enzymatic reaction mixture enhances the umami intensity of commercial soy sauce and model chicken broth .
γ-Glu-Phe TFA (γ-Glutamylphenylalanine TFA) is synthesized by Bacillus amyloliquefaciens (GBA) and Aspergillus oryzae (GAO). γ-Glu-Phe TFA or the post-enzymatic reaction mixture enhances the umami intensity of commercial soy sauce and model chicken broth .
N-Acetyl-DL-serine is a hydrophobic amino acid that is synthesized in the body and can be found as a free form or as a salt with malonate, phosphate, or acetate. N-Acetyl-DL-serine has antimicrobial activity against Bacillus cereus and Staphylococcus aureus. N-Acetyl-DL-serine has also been used for the immobilization of DNA fragments on solid surfaces and can be used for protein synthesis and optical detection of DNA strands .
Cyclo(L-Trp-L-Trp) is an antibiotic, and shows antimicrobial activity. Cyclo(L-Trp-L-Trp) can inhibit A. baumannii, as well as Candida albicans, Bacillus subtilis, Micrococcus luteus, Saccharomyces cerevisiae, Aspergillus niger, Staphylococcus aureus. Cyclo(L-Trp-L-Trp) can be used in microbial infection research .
Gageotetrin A is an antimicrobial peptide derived from the marine bacterium Bacillus subtilis. Gageotetrin A has antifungal activity, but none toxic to numerous human cancer cells .
Maximin H2 is an antimicrobial peptide derived from the skin secretions of Chinese red belly toad Bombina maxima. Maximin H2 has activity against Escherichia coli ATCC25922, Staphylococcus aureus ATCC2592, Bacillus pyocyaneus CMCCB1010 and Candida albicans ATCC2002, the MIC values are 20, 2, 4, 2 μg/ml, respectively .
Maximin H3 is an antimicrobial peptide derived from the skin secretions of Chinese red belly toad Bombina maxima. Maximin H3 has activity against Escherichia coli ATCC25922, Staphylococcus aureus ATCC2592, Bacillus pyocyaneus CMCCB1010 and Candida albicans ATCC2002, the MIC values are 20, 10, 20, 5 μg/ml, respectively .
Maximin H4 is an antimicrobial peptide derived from the skin secretions of Chinese red belly toad Bombina maxima. Maximin H4 has activity against Escherichia coli ATCC25922, Staphylococcus aureus ATCC2592, Bacillus pyocyaneus CMCCB1010 and Candida albicans ATCC2002, the MIC values are 12, 6, 12, 6 μg/ml, respectively .
Maximin H1 is an antimicrobial peptide derived from the skin secretions of Chinese red belly toad Bombina maxima. Maximin H1 has activity against Escherichia coli ATCC25922, Staphylococcus aureus ATCC2592, Bacillus pyocyaneus CMCCB1010 and Candida albicans ATCC2002, the MIC values are 9, 4.5, 9, 4.5 μg/ml, respectively .
Maximin 31 is an antimicrobial peptide derived from the toad brain. Maximin 31 is active against Staphylococcus aureus and Escherichia coli, with MIC values of 37.5, 75 μg/mL, respectively .
Maximin 32 is an antimicrobial peptide derived from the toad brain. Maximin 32 is active against Staphylococcus aureus and Escherichia coli, with MIC values of 9.4, 18.8 μg/mL, respectively .
Maximin 39 is an antimicrobial peptide derived from the toad brain. Maximin 39 is active against Staphylococcus aureus and Escherichia coli, with MIC values of 18.8, 37.5 μg/mL, respectively .
Polymixin B is a mixture of B1 and B2 polypeptides obtained from different strains of Bacillus polymyxa, with antibacterial activity against gram-negative bacteria. It can bind lipopolysaccharide (LPS) of the outer membrane of gram-negative bacteria and disrupts the cytoplasmic membrane by inducing large pores to allow nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane.
Bst DNA Polymerase is derived from Bacillus stearothermophilus and has 5'→3' DNA polymerase activity and double-stranded specific 5'→3' exonuclease activity.
Bst DNA Polymerase large fragment is a part of Bacillus stearothermophilus DNA polymerase, which is derived from E. coli strain. It is expressed in E. coli and purified and isolated multiple times.
Raxibacumab (ABthrax) is a human IgG1 monoclonal antibody against Bacillus anthracis protective antigen (PA). Raxibacumab blocks the toxin’s deleterious effects by preventing binding of the protective antigen component of the anthrax toxin to its receptors in host cells, thereby blocking the toxin’s deleterious effects. Raxibacumab can be used for anti-anthrax research .
Massarigenin C is a compound that can be isolated from Massarina tunicata. Massarigenin C has inhibitory activity against Bacillus subtilis (ATCC 6051) .
Talaroderxine D (compound 4) has biofilm inhibitory effect. Talaroderxine D shows antimicrobial activities against Bacillus subtilis and Staphylococcus aureus with MIC values of 2.1 and 8.3 μg/mL .
Maximin 15 is an antimicrobial peptide derived from the toad brain. Maximin 15 is active against Staphylococcus aureus, Escherichia coli and Bacillus subtilis, with MIC values of 9.4, 18.8, 75 μg/mL, respectively .
Maximin 28 is an antimicrobial peptide derived from the toad brain. Maximin 28 is active against Staphylococcus aureus, Escherichia coli and Bacillus subtilis, with MIC values of 4.7, 9.4, 75 μg/mL, respectively .
γ-Glu-Phe (γ-Glutamylphenylalanine) is synthesized by Bacillus amyloliquefaciens (GBA) and Aspergillus oryzae (GAO). γ-Glu-Phe or the post-enzymatic reaction mixture enhances the umami intensity of commercial soy sauce and model chicken broth .
γ-Glu-Phe TFA (γ-Glutamylphenylalanine TFA) is synthesized by Bacillus amyloliquefaciens (GBA) and Aspergillus oryzae (GAO). γ-Glu-Phe TFA or the post-enzymatic reaction mixture enhances the umami intensity of commercial soy sauce and model chicken broth .
Kumbicin C is a bis-indolyl benzenoid compound from an Australian soil fungus, Aspergillus kumbius. Kumbicin C inhibits the growth of mouse myeloma cells and the Gram-positive bacterium Bacillus subtilis .
Pulcherriminic acid is a cyclic dipeptide antimicrobial agent with high affinity for Fe 3+, found mainly in Bacillus and yeast. Pulcherriminic acid chelates iron ions through a non-enzymatic reaction to form the extracellular red pigment pulcherrimin, which competes for iron nutrition and thus achieves an antibacterial effect. Pulcherriminic acid has great applications in food, agriculture and medical industries .
Globulol, antimicrobial sesquiterpene, is a natural product with antimicrobial activity. Globulol can be isolated from the fruits of Eucalyptus globulus Labill. Globulol shows antimicrobial activity against Xanthomonas vesicatoria and Bacillus subtilis, the IC50 value of 158.0 μg/mL and 737.2 μg/mL, respectively .
Bipolaricin R (Compound 6) is a compound that can be isolated from Bipolaris maydis. Bipolaricin R exhibits noticeable antimicrobial ability against Bacillus cereus, Staphylococcus aureus, and Staphylococcus epidermidis. Bipolaricin R has excellent antiproliferation and apoptosis induction effects against A549 cell line .
4-Ethoxyphenol is a natural compound isolated from marine gorgonian-associated bacterium Bacillus amyloliquefaciens SCSIO 00856. 4-Ethoxyphenol shows potent antilarval activity towards Bacillus amphitrite larvae with an EC50 value of 24.1 μg/mL .
N2-Acetylguanine is a C2-modified guanine. N2-Acetylguanine binds GR (guanine-guanine riboswitch) with an Kd value of 300 nM. N2-Acetylguanine modulate transcriptional termination. N2-Acetylguanine has the potential for the research of antimicrobial agent .
Pycnophorin significantly inhibits the growth of Bacillus subtilis and Staphyloccocus aureus with equal minimum inhibitory concentration (MIC) values of 25 μM.
Monascorubrin is purified from the mycelium of Monascus purpureus. Monascorubrin has significant antibiotic activities against Bacillus subtilis and Candida pseudotropicalis .
Betonicine (Achilleine), an alkaloid, has cell protectant activity. Betonicine protects Bacillus subtilis against extremes in osmolarity and growth temperatures .
Macatrichocarpin A is a flavanone with anti-bacterial activity. Macatrichocarpin A inhibits Bacillus subtilis with MIC value of 26.5 μM. Macatrichocarpin A can be isolated from the leaves of Macaranga trichocarpa .
Fraxidin is a class of coumarin isolated from the roots of Jatropha podagrica, exhibits antibacterial activity against Bacillus subtilis with an inhibition zone of 12 mm at a concentration of 20 µg/disk .
(1R)-α-Pinene is a volatile monoterpene with antimicrobial activities. (1R)-α-Pinene reduces Bacillus cereus population growth, and exhibits repellent effects .
9-(4′-Hydroxyphenyl)-2-methoxyphenalen-1-one is a phytoalexin and mixed competitive α-glucosidase inhibitor of Bacillus stearothermophilus (IC50: 3.86 mg/L) .
Asperglaucin A represents an unusual phthalide-like derivative. Asperglaucin A exhibits potent antibacterial activities against two plant pathogens Pseudomonas syringae pv actinidae (Psa) and Bacillus cereus, with an MIC value of 6.25 μM .
Monocerin is an isocoumarin derivative. Monocerin is isolated from Microdochium bolleyi, an endophytic fungus from Fagonia cretica. Monocerin shows good antifungal, antibacterial, and antialgal activities against Microbotryum violaceum, Escherichia coli, Bacillus megaterium, and Chlorella fusca .
Reutericyclin (Reutericycline), a unique tetramic acid, is an antibiotic produced by some strains of Lactobacillus reuteri. Reutericyclin (Reutericycline) exhibits a broad inhibitory spectrum including Lactobacillus spp., Bacillus subtilis, B. cereus, Enterococcus faecalis, Staphylococcus aureus, and Listeria innocua .
Tyrothricin is a polypeptide antibiotic mixture isolated from Bacillus brevis and consists of tyrocidines and gramicidins. Tyrothricin shows activity against bacteria, fungi and some viruses. Tyrothricin containing formulations are used in sore throat agents and in agents for the healing of infected superficial and small-area wounds .
Asperglaucin B is an alkylated salicylaldehyde derivative from the fungus Aspergillus chevalieri SQ-8, with antibacterial activities. Asperglaucin B displays potent antibacterial activities against two plant pathogens Pseudomonas syringae pv actinidae (Psa) and Bacillus cereus, with an MIC value of 6.25 μM .
Blepharotriol is a phenolic triterpene that can be found in Maytenus blepharodes. Blepharotriol shows antimicrobial activity with a MIC value of 8-4 µg/ml for Bacillus subtilis. Blepharotriol shows cytotoxic activity with IC50s of 12.2, >20, >20 µM for HeLa, Hep-2, Vero cells, respectively .
Enfumafungin, a triterpene glycoside, is isolated from extracts derived from fungus Hormonema carpetanum. Enfumafungin is an antifungal compound that is acting on the fungal cell wall, as the (1,3)-beta-D-glucan synthase inhibitor. Enfumafungin is specific for yeasts and fungi (excluding Cryptococcus) and does not inhibit the growth of Bacillus subtilis .
Macrocarpal A (10-epi-Eucarobustol F) is an antibacterial agent, which can be isolated from the leaves of Eucalyptus macrocarpa. Macrocarpal A inhibits the growth of Bacillus subtilis PCI219 (minimum inhibitory concentration below 0.2 µM) and Staphylococcus aureus FDA209P (minimum inhibitory concentration is 0.4 µM) .
(R)-4-Methoxydalbergione is a urease inhibitor with IC50s of 59.72 and 67.33 μM for Bacillus pasteurii urease and Jack bean urease. (R)-4-Methoxydalbergione also has antiplasmodial activity. (R)-4-Methoxydalbergione can be isolated from Ranunculus repens .
Maximin 31 is an antimicrobial peptide derived from the toad brain. Maximin 31 is active against Staphylococcus aureus and Escherichia coli, with MIC values of 37.5, 75 μg/mL, respectively .
Maximin 32 is an antimicrobial peptide derived from the toad brain. Maximin 32 is active against Staphylococcus aureus and Escherichia coli, with MIC values of 9.4, 18.8 μg/mL, respectively .
Maximin 39 is an antimicrobial peptide derived from the toad brain. Maximin 39 is active against Staphylococcus aureus and Escherichia coli, with MIC values of 18.8, 37.5 μg/mL, respectively .
Micronomicin sulfate (Gentamicin C2b sulfate) is an aminoglycoside antibiotic isolated from Micromonospora. Micronomicin sulfate is a broad-spectrum antibiotic close to the gentamicin-type antibiotics, exhibits a high activity against Pseudomonas, Proteus, Klebsiella pneumoniae, Serratia, etc (MIC=0.001-8.3 μg/ml) .
Cellooctaose is an oligosaccharide, consisting of eight glucose residues. Cellooctaose is a low-cost polysaccharides in fermentation to hold on Lactococcus lactis recombinant strain growth. Cellooctaose is the substrate of beta-glucosidase (E.C. 3.2.1.21) .
(9Z)-9,17-Octadecadiene-12,14-diyne-1,11,16-triol is a nature product that could be isolated from the ethyl acetate extract of Cassonia barteri (Araliaceae) leaves. (9Z)-9,17-Octadecadiene-12,14-diyne-1,11,16-triol has antibacterial activity against Bacillus subtilis and Pseudomonas fluorescens, antifungal activity against Cladosporium cucumerinum, moiluscicidal activity against Biomphalaria glabrata . (9Z)-9,17-Octadecadiene-12,14-diyne-1,11,16-triol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Catalase proteins play an essential role in cellular defense mechanisms by catalyzing the degradation of hydrogen peroxide (H(2)O(2)), a reactive oxygen species produced by peroxisomal oxidases, into water and oxygen. crucial role. This enzyme activity is an important line of defense, protecting cells from the toxic effects of hydrogen peroxide. Catalase Protein, Bacillus is the recombinant Catalase protein, expressed by E. coli , with tag free. The total length of Catalase Protein, Bacillus is 483 a.a., .
Catalase proteins play an essential role in cellular defense mechanisms by catalyzing the degradation of hydrogen peroxide (H(2)O(2)), a reactive oxygen species produced by peroxisomal oxidases, into water and oxygen. crucial role. This enzyme activity is an important line of defense, protecting cells from the toxic effects of hydrogen peroxide. Catalase Protein, Bacillus (FLAG, His) is the recombinant Catalase protein, expressed by E. coli , with N-6*His, N-Flag labeled tag. The total length of Catalase Protein, Bacillus (FLAG, His) is 483 a.a., .
The InuB protein plays a key role in promoting the bacterium's ability to metabolize sucrose as a sole carbon source. This protein functions as an integral part of the bacterial metabolic process, allowing it to efficiently utilize sucrose for energy and growth. inuB Protein, Bacillus licheniformis is the recombinant inuB protein, expressed by E. coli , with tag free. The total length of inuB Protein, Bacillus licheniformis is 492 a.a., .
L-arabinose isomerase is a key enzyme in carbohydrate metabolism and plays a key role in catalyzing the conversion of L-arabinose to L-ribulose. This enzymatic activity is part of a broader biochemical pathway involved in the interconversion of sugars. L-arabinose isomerase Protein, Bacillus subtilis is the recombinant L-arabinose isomerase protein, expressed by E. coli , with tag free. The total length of L-arabinose isomerase Protein, Bacillus subtilis is 496 a.a., .
The InuB protein plays a key role in promoting the bacterium's ability to metabolize sucrose as a sole carbon source. This protein functions as an integral part of the bacterial metabolic process, allowing it to efficiently utilize sucrose for energy and growth. inuB Protein, Bacillus licheniformis (His) is the recombinant inuB protein, expressed by E. coli , with N-6*His labeled tag. The total length of inuB Protein, Bacillus licheniformis (His) is 492 a.a., .
L-arabinose isomerase is a key enzyme in carbohydrate metabolism and plays a key role in catalyzing the conversion of L-arabinose to L-ribulose. This enzymatic activity is part of a broader biochemical pathway involved in the interconversion of sugars. L-arabinose isomerase Protein, Bacillus subtilis (His) is the recombinant L-arabinose isomerase protein, expressed by E. coli , with N-6*His labeled tag. The total length of L-arabinose isomerase Protein, Bacillus subtilis (His) is 496 a.a., .
Monomeric sarcosine oxidase protein is pivotal in cellular metabolism, catalyzing the oxidative demethylation of sarcosine. Its enzymatic activity facilitates the removal of a methyl group from sarcosine, contributing to metabolic transformations in various biochemical pathways. This process underscores the protein's significance in regulating cellular methyl group transfers, emphasizing its crucial role in maintaining metabolic homeostasis. monomeric sarcosine oxidase Protein, Bacillus sp. is the recombinant monomeric sarcosine oxidase protein, expressed by E. coli , with tag free. The total length of monomeric sarcosine oxidase Protein, Bacillus sp. is 387 a.a., .
Cephalosporin C deacetylase Protein, an esterase, selectively removes acetyl groups from substrates like acetylated xylose and cephalosporin C. Its catalytic activity excludes polymeric acetylated xylan and amide linkages, highlighting its nuanced, targeted deacetylation function. Cephalosporin C deacetylase Protein, Bacillus subtilis is the recombinant Cephalosporin C deacetylase protein, expressed by E. coli , with tag free. The total length of Cephalosporin C deacetylase Protein, Bacillus subtilis is 318 a.a., .
Monomeric sarcosine oxidase protein is pivotal in cellular metabolism, catalyzing the oxidative demethylation of sarcosine. Its enzymatic activity facilitates the removal of a methyl group from sarcosine, contributing to metabolic transformations in various biochemical pathways. This process underscores the protein's significance in regulating cellular methyl group transfers, emphasizing its crucial role in maintaining metabolic homeostasis. monomeric sarcosine oxidase Protein, Bacillus sp. (His) is the recombinant monomeric sarcosine oxidase protein, expressed by E. coli , with N-6*His labeled tag. The total length of monomeric sarcosine oxidase Protein, Bacillus sp. (His) is 387 a.a., .
IDO Protein, an enzyme, is involved in the conversion of tryptophan to kynurenine. Dysregulation of IDO Protein has been associated with immune suppression and tumor development. Targeting IDO Protein may present potential therapeutic approaches in cancer by modulating tryptophan metabolism, restoring immune responses, and inhibiting tumor growth. ido Protein, Bacillus thuringiensis is the recombinant ido protein, expressed by E. coli , with tag free. The total length of ido Protein, Bacillus thuringiensis is 240 a.a., .
Sensor histidine kinase NatK Protein, a NatK/NatR system component, positively regulates natAB operon expression. It can phosphorylate NatR, mediating signal transduction in bacterial cells. The NatK/NatR system exemplifies a molecular mechanism for modulating gene expression, emphasizing the intricate regulatory processes orchestrated by sensor histidine kinases in bacterial signaling pathways. Sensor histidine kinase NatK Protein, Bacillus subtilis (Cell-Free, His) is the recombinant Sensor histidine kinase NatK protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of Sensor histidine kinase NatK Protein, Bacillus subtilis (Cell-Free, His) is 318 a.a., with molecular weight of 36.6 kDa.
IDO Protein, an enzyme, is involved in the conversion of tryptophan to kynurenine. Dysregulation of IDO Protein has been associated with immune suppression and tumor development. Targeting IDO Protein may present potential therapeutic approaches in cancer by modulating tryptophan metabolism, restoring immune responses, and inhibiting tumor growth. ido Protein, Bacillus thuringiensis (FLAG, His) is the recombinant ido protein, expressed by E. coli , with N-6*His, N-Flag labeled tag. The total length of ido Protein, Bacillus thuringiensis (FLAG, His) is 240 a.a., .
The gucD protein is an important enzyme that catalyzes the irreversible ammonia removal of L-kynurenine to generate kynurenic acid (KA). This process is part of the tryptophan catabolic pathway and produces KA, known for its broad-spectrum antagonistic activity at excitatory amino acid receptors. gucD Protein, Bacillus subtilis is the recombinant gucD protein, expressed by E. coli , with tag free. The total length of gucD Protein, Bacillus subtilis is 487 a.a., .
TMK proteins play a central role by catalyzing the phosphorylation of deoxythymidine monophosphate (dTMP), a key step in the synthesis of deoxythymidine triphosphate (dTTP). This process converts dTMP into deoxythymidine diphosphate (dTDP), an important intermediate in dTTP biosynthesis. TMK Protein, Bacillus anthracis (His) is the recombinant TMK protein, expressed by E. coli , with N-6*His labeled tag. The total length of TMK Protein, Bacillus anthracis (His) is 208 a.a., with molecular weight of ~25 kDa.
The Dit protein is an important component that forms a 40 Å wide channel distal to the tail in its homohexameric structure. This unique channel structure plays a crucial role in cellular processes and may facilitate DNA ejection. Dit Protein, Bacillus phage SPP1 is the recombinant Dit protein, expressed by E. coli , with tag free. The total length of Dit Protein, Bacillus phage SPP1 is 140 a.a., .
The gucD protein is an important enzyme that catalyzes the irreversible ammonia removal of L-kynurenine to generate kynurenic acid (KA). This process is part of the tryptophan catabolic pathway and produces KA, known for its broad-spectrum antagonistic activity at excitatory amino acid receptors. gucD Protein, Bacillus subtilis (His, Strep) is the recombinant gucD protein, expressed by E. coli , with N-Strep, N-6*His labeled tag. The total length of gucD Protein, Bacillus subtilis (His, Strep) is 487 a.a., .
YUAB is an important contributor to biofilm formation, self-polymerizing to form a hydrophobic layer with excellent stability and resistance to mechanical compression. YUAB is essential for complex colony structure, interacting synergistically with exopolysaccharides and TasA amyloid fibrils to facilitate biofilm matrix assembly. YUAB Protein, Bacillus subtilis (Cell-Free, His-SUMO) is the recombinant YUAB protein, expressed by E. coli Cell-free , with N-His, N-SUMO labeled tag. The total length of YUAB Protein, Bacillus subtilis (Cell-Free, His-SUMO) is 181 a.a., with molecular weight of ~35.3 kDa.
The Dit protein is an important component that forms a 40 Å wide channel distal to the tail in its homohexameric structure. This unique channel structure plays a crucial role in cellular processes and may facilitate DNA ejection. Dit Protein, Bacillus phage SPP1 (FLAG, His) is the recombinant Dit protein, expressed by E. coli , with N-6*His, N-Flag labeled tag. The total length of Dit Protein, Bacillus phage SPP1 (FLAG, His) is 140 a.a., .
Dalbavancin-d6 is the deuterium labeled Dalbavancin[1]. Dalbavancin (MDL-63397) is a semisynthetic lipoglycopeptide antibiotic with potent bactericidal activity against Gram-positive bacteria. Dalbavancin inhibits Staphylococcus aureus and Bacillus anthracis with MIC90s of 0.06 μg/mL and 0.25 μg/mL, respectively[2][3].
Inquiry Online
Your information is safe with us. * Required Fields.
