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Results for "

Bad

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (6) Autophagy (2) Bcl-2 Family (4) Bcr-Abl (1) DNA/RNA Synthesis (1) EGFR (1) HBV (1) HIV (2) Isotope-Labeled Compounds (1) mTOR (1) Pim (5) Proteasome (1) Reverse Transcriptase (2) Ribosomal S6 Kinase (RSK) (1) Small Interfering RNA (siRNA) (1) Src (1)
By Research Areas:	Cancer (12) Infection (3)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2468

BAD (103-127) (human) BadBH3 103-127 (human); BadBH3 (human)	Bcl-2 Family	Cancer
BAD (103-127) (human), the 25-mer Bad peptide, is derived from the BH3 domain of BAD, can antagonize the function of Bcl-xL. BAD (103-127) (human) is reported to have almost 800-fold higher affinity for Bcl-XL than the 16-mer peptide .

HY-P2499

BAD (103-127) (human), FAM-labeled	Bcl-2 Family	Cancer
BAD (103-127) (human), FAM-labeled is a FAM-labeled human BAD (103-127) (HY-P2468). BAD (103-127) (human), the 25-mer Bad peptide, is derived from the BH3 domain of BAD, can antagonize the function of Bcl-xL .

HY-P5324

Bad BH3 (mouse)	Bcl-2 Family	Others
Bad BH3 (mouse) is a biological active peptide. (This is a bcl-2 binding peptide. This peptide is derived from the BH3 domain (a death domain) of Bad, amino acid residues 140 to 165.)

HY-RS01341

BAD Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
BAD Human Pre-designed siRNA Set A contains three designed siRNAs for BAD gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BAD Human Pre-designed siRNA Set A BAD Human Pre-designed siRNA Set A

HY-15901A

LGB321 monohydrochloride	Pim mTOR	Cancer
LGB321 monohydrochloride is a potent, selective, orally active and ATP competitive inhibitor of all three PIM kinases. LGB321 monohydrochloride inhibits proliferation, mTOR-C1 signaling and phosphorylation of BAD in a number of cell lines derived from diverse hematologic malignancies. LGB321 monohydrochloride can be used for the research of hematologic malignancies .

HY-120035

DD1	Proteasome Ribosomal S6 Kinase (RSK) Apoptosis	Cancer
DD1, a proteasome inhibitor, targets Bax activation and P70S6K degradation during acute myeloid leukemia (AML) apoptosis. DD1 induces apoptosis in the caspase-dependent manner. DD1 induces mitochondrial membrane depolarization and Bad dephosphorylation .

HY-119368

NPB

Bcl-2 Family Cancer

NPB is a specific and potent inhibitor of BAD phosphorylation at Ser99, with an IC₅₀ of 0.41 μM .
HY-18095

CX-6258

Pim Cancer

CX-6258 is a potent and kinase selective pan-Pim kinases inhibitor, with IC₅₀s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively .

NPB	Bcl-2 Family	Cancer
NPB is a specific and potent inhibitor of BAD phosphorylation at Ser99, with an IC₅₀ of 0.41 μM .

CX-6258	Pim	Cancer
CX-6258 is a potent and kinase selective pan-Pim kinases inhibitor, with IC₅₀s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively .

HY-18095A

CX-6258 hydrochloride hydrate	Pim	Cancer
CX-6258 hydrochloride hydrate is a potent and kinase selective pan-Pim kinases inhibitor, with IC₅₀s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively .

HY-18095B

CX-6258 hydrochloride	Pim	Cancer
CX-6258 hydrochloride is a potent and kinase selective pan-Pim kinases inhibitor, with IC₅₀s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively .

HY-14266

Dapivirine 2 Publications Verification TMC120; R147681	HIV Reverse Transcriptase Apoptosis Autophagy	Infection
Dapivirine (TMC120), the prototype of diarylpyrimidines (DAPY), is an orally active and nonnucleoside reverse transcriptase inhibitor (NRTI). Dapivirine (TMC120) binds directly to HIV-1 reverse transcriptase. Dapivirine (TMC120) regulates autophagy and induced Akt, Bad and SAPK/JNK activations .

HY-14266S

Dapivirine-d11 TMC120-d₁₁; R147681-d₁₁	Isotope-Labeled Compounds HIV Reverse Transcriptase Apoptosis Autophagy	Infection
Dapivirine-d₁₁ is the deuterium labeled Dapivirine. Dapivirine (TMC120), the prototype of diarylpyrimidines (DAPY), is an orally active and nonnucleoside reverse transcriptase inhibitor (NRTI). Dapivirine (TMC120) binds directly to HIV-1 reverse transcriptase. Dapivirine (TMC120) regulates autophagy and induced Akt, Bad and SAPK/JNK activations[1][2].

HY-50868

Bafetinib 5+ Cited Publications INNO-406; NS-187	Bcr-Abl Src Apoptosis	Cancer
Bafetinib is an orally active Lyn/Bcr-Abl tyrosine kinase inhibitor. Bafetinib enhances the activity of several pro-apoptotic Bcl-2 homology (BH) 3-pure proteins (Bim, Bad, Bmf, and Bik) through intrinsic apoptotic pathways regulated by the Bcl-2 family, and induces apoptosis of Ph ⁺ leukemia cells. Bafetinib has antitumor activity .

HY-111552

PIM1-IN-1	Pim	Cancer
PIM1-IN-1 is a potent and highly selective PIM1/3 inhibitor, with IC₅₀s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively, inhibits the phosphorylation of BAD, a downstream target of PIM, with an EC₅₀ of 262 nM. PIM1-IN-1 shows no obvious effect on FLT3 or hERG binding. Antiproliferative and anti-cancer activity .

HY-146395

HBV-IN-23	HBV DNA/RNA Synthesis Apoptosis	Infection Cancer
HBV-IN-23 (Compound 5k) is an inhibitor of HBV DNA replication with an IC₅₀ of 0.58 μM. HBV-IN-23 inhibits HBV DNA replication in both agent sensitive and resistant HBV strains. HBV-IN-23 shows anti-hepatocellular carcinoma cell (HCC) activities. HBV-IN-23 induces HepG2 cells apoptosis .

HY-145844

EGFR-IN-44	EGFR Apoptosis	Cancer
EGFR-IN-44 (Compound 6a) is a potent, orally active EGFR tyrosine kinase inhibitor with an IC₅₀ of 4.11 nM. EGFR-IN-44 induces cell apoptosis and shows an oral bioavailability value of 33.57%. EGFR-IN-44 can be studied for non-small-cell lung cancers .

Cat. No.	Product Name	Target	Research Area

HY-P2468

BAD (103-127) (human) BadBH3 103-127 (human); BadBH3 (human)	Bcl-2 Family	Cancer
BAD (103-127) (human), the 25-mer Bad peptide, is derived from the BH3 domain of BAD, can antagonize the function of Bcl-xL. BAD (103-127) (human) is reported to have almost 800-fold higher affinity for Bcl-XL than the 16-mer peptide .

HY-P2499

BAD (103-127) (human), FAM-labeled	Bcl-2 Family	Cancer
BAD (103-127) (human), FAM-labeled is a FAM-labeled human BAD (103-127) (HY-P2468). BAD (103-127) (human), the 25-mer Bad peptide, is derived from the BH3 domain of BAD, can antagonize the function of Bcl-xL .

HY-P5324

Bad BH3 (mouse)	Bcl-2 Family	Others
Bad BH3 (mouse) is a biological active peptide. (This is a bcl-2 binding peptide. This peptide is derived from the BH3 domain (a death domain) of Bad, amino acid residues 140 to 165.)

Species:	Human (2) Virus (2) Mouse (1) Cynomolgus (1)
Tag:	His (4) Fc (2)
Source:	HEK293 (6)

Cat. No.	Compare	Product Name	Species	Source

HY-P77978

	*LAMP5/BAD-LAMP Protein, Human (HEK293, Fc)* Bad-LAMP; LAMP-5; BadLAMP; C20orf103; dJ1119D9.3; UNC-43	Human	HEK293
	LAMP5/BAD-LAMP protein plays a role in short-term synaptic plasticity within a specific subset of GABAergic neurons in the brain. LAMP5/BAD-LAMP Protein, Human (HEK293, Fc) is the recombinant human-derived LAMP5/BAD-LAMP protein, expressed by HEK293 , with C-hFc labeled tag. The total length of LAMP5/BAD-LAMP Protein, Human (HEK293, Fc) is 206 a.a., with molecular weight of 60-70 kDa.

HY-P700775

	*LAMP5/BAD-LAMP Protein, Human (HEK293, His)* Bad-LAMP; LAMP-5; BadLAMP; C20orf103; dJ1119D9.3; UNC-43	Human	HEK293
	LAMP5/BAD-LAMP protein plays a role in short-term synaptic plasticity within a specific subset of GABAergic neurons in the brain. LAMP5/BAD-LAMP Protein, Human (HEK293, His) is the recombinant human-derived LAMP5/BAD-LAMP protein, expressed by HEK293 , with C-His labeled tag. The total length of LAMP5/BAD-LAMP Protein, Human (HEK293, His) is 206 a.a., with molecular weight of 30-40 kDa.

HY-P77733

	LAMP5 Protein, Mouse (HEK293, Fc) Bad-LAMP; LAMP-5; BadLAMP; C20orf103; dJ1119D9.3; UNC-43	Mouse	HEK293
	LAMP5 Protein significantly contributes to short-term synaptic plasticity in a specific subset of GABAergic neurons in the brain. LAMP5 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived LAMP5 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of LAMP5 Protein, Mouse (HEK293, Fc) is 206 a.a., with molecular weight of 60-70 kDa.

HY-P700774

	LAMP5 Protein, Cynomolgus (HEK293, His) Bad-LAMP; LAMP-5; BadLAMP; C20orf103; dJ1119D9.3; UNC-43	Cynomolgus	HEK293
	LAMP5 Protein, a member of the LAMP family, is delineated. LAMP5 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived LAMP5 protein, expressed by HEK293, with C-His labeled tag. The total length of LAMP5 Protein, Cynomolgus (HEK293, His) is 206 a.a., with molecular weight of 30-40 kDa.

HY-P73984

	*HA/Hemagglutinin Protein, H5N1 (BAD89305, 340a.a, HEK293, His)* HA; Hemagglutinin; HA/Hemagglutinin Protein, H5N1 (A/chicken/Yamaguchi/7/2004, HEK293, His)	Virus	HEK293
	The hemagglutinin (HA) protein attaches viral particles to host cells by binding to sialic acid-containing receptors and induces viral particle internalization through clathrin-dependent endocytosis. HA also promotes an alternative clathrin- and caveolin-independent pathway for some virions. HA/Hemagglutinin Protein, H5N1 (BAD89305, 340a.a, HEK293, His) is the recombinant Virus-derived HA/Hemagglutinin protein, expressed by HEK293 , with C-His labeled tag. The total length of HA/Hemagglutinin Protein, H5N1 (BAD89305, 340a.a, HEK293, His) is 340 a.a., with molecular weight of ~60 kDa.

HY-P75033

	*HA/Hemagglutinin Protein, H5N1 (BAD89305, 530a.a, HEK293, His)* Influenza A H5N1 (A/chicken/Yamaguchi/7/2004) Hemagglutinin / HA Protein (HEK293, His)	Virus	HEK293
	The hemagglutinin (HA) protein attaches viral particles to host cells by binding to sialic acid-containing receptors and induces viral particle internalization through clathrin-dependent endocytosis. HA also promotes an alternative clathrin- and caveolin-independent pathway for some virions. HA/Hemagglutinin Protein, H5N1 (BAD89305, 530a.a, HEK293, His) is the recombinant Virus-derived HA/Hemagglutinin protein, expressed by HEK293 , with C-His labeled tag. The total length of HA/Hemagglutinin Protein, H5N1 (BAD89305, 530a.a, HEK293, His) is 530 a.a., with molecular weight of ~60 kDa.


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Dapivirine-d11
Dapivirine-d₁₁ is the deuterium labeled Dapivirine. Dapivirine (TMC120), the prototype of diarylpyrimidines (DAPY), is an orally active and nonnucleoside reverse transcriptase inhibitor (NRTI). Dapivirine (TMC120) binds directly to HIV-1 reverse transcriptase. Dapivirine (TMC120) regulates autophagy and induced Akt, Bad and SAPK/JNK activations[1][2].

Cat. No.	Product Name	Application	Reactivity

HY-P80025

Bad Antibody	WB, ICC/IF, IHC-P, FC, IP	Human
Bad Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 18 kDa, targeting to Bad. It can be used for WB,ICC/IF,IHC-P,FC,IP assays with tag free, in the background of Human.

HY-P83354

*Phospho-Bad* (Ser112) Antibody (YA3099)** Bad; BBC6; BCL2L8; Bcl2 antagonist of cell death; Bad; Bcl-2-binding component 6; Bcl-2-like protein 8; Bcl2-L-8; Bcl-XL/Bcl-2-associated death promoter	WB, IP	Human, Mouse, Rat

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