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Results for "

Bcl-2-IN-2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bcl-2 Family (20) Apoptosis (12) Autophagy (4) Beclin1 (2) Biochemical Assay Reagents (1) c-Myc (1) Caspase (3) EGFR (1) Epigenetic Reader Domain (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Mitophagy (1) NF-κB (1) Parasite (3) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (24) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (2)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Bcl-2 Family BCL6 AIM2 NEKs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-129700

MCL-1/BCL-2-IN-2

Bcl-2 Family Cancer

MCL-1/BCL-2-IN-2 (Compound 6) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor .

MCL-1/BCL-2-IN-2	Bcl-2 Family	Cancer
MCL-1/BCL-2-IN-2 (Compound 6) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor .

HY-131247

*Bcl-2-IN-2*	Bcl-2 Family	Inflammation/Immunology Cancer
Bcl-2-IN-2 is a potent and selective Bcl-2 inhibitor with an IC₅₀ of 0.034 nM and also inhibits Bcl-xL with an IC₅₀ of 43 nM, showing >1000-fold selectivity for Bcl-2 over Bcl-xL .

HY-RS01434

BCL2L2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
BCL2L2 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2L2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BCL2L2 Human Pre-designed siRNA Set A BCL2L2 Human Pre-designed siRNA Set A

HY-RS01435

Bcl2l2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Bcl2l2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bcl2l2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bcl2l2 Mouse Pre-designed siRNA Set A Bcl2l2 Mouse Pre-designed siRNA Set A

HY-RS01436

Bcl2l2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Bcl2l2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Bcl2l2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bcl2l2 Rat Pre-designed siRNA Set A Bcl2l2 Rat Pre-designed siRNA Set A

HY-129681

MCL-1/BCL-2-IN-1

Bcl-2 Family Cancer

MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor with IC₅₀s of 4.45 and 3.18 μM, respectively .
HY-157176

BAX-IN-1

Others Others

BAX-IN-1 is a potential, selective inhibitor of Bcl-2-associated X protein (BAX).
HY-109185

Pelcitoclax

APG-1252
Bcl-2 Family Apoptosis Cancer

Pelcitoclax (APG-1252) is a potent Bcl-2/Bcl-xl inhibitor with antineoplastic and pro-apoptotic effects .
HY-125191

BRD1991

Bcl-2 Family Beclin1 Cancer

BRD1991 selectively disrupts Beclin 1/Bcl-2 binding and induces autophagy without triggering apoptosis or other forms of cell death .

MCL-1/BCL-2-IN-1	Bcl-2 Family	Cancer
MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor with IC₅₀s of 4.45 and 3.18 μM, respectively .

BAX-IN-1	Others	Others
BAX-IN-1 is a potential, selective inhibitor of Bcl-2-associated X protein (BAX).

Pelcitoclax APG-1252	Bcl-2 Family Apoptosis	Cancer
Pelcitoclax (APG-1252) is a potent *Bcl-2/Bcl-xl* inhibitor with antineoplastic and pro-apoptotic effects .

BRD1991	Bcl-2 Family Beclin1	Cancer
BRD1991 selectively disrupts Beclin 1/Bcl-2 binding and induces autophagy without triggering apoptosis or other forms of cell death .

HY-33350

Clofilium tosylate
Clofilium tosylate, a potassium channel blocker, induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspase-3. Antiarrhythmic agent .

HY-161100

BDM19

Apoptosis Cancer

BDM19 binds and activates cytosolic BAX dimers, and prompts cell apoptosis either alone or in combination with BCL-2/BCL-XL inhibitor Navitoclax (HY-10087) .

BDM19	Apoptosis	Cancer
BDM19 binds and activates cytosolic BAX dimers, and prompts cell apoptosis either alone or in combination with BCL-2/BCL-XL inhibitor Navitoclax (HY-10087) .

HY-119931

2-Hydroxychalcone	Bcl-2 Family Apoptosis NF-κB Parasite	Metabolic Disease Cancer
2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB .

HY-103243

TCPOBOP 1 Publications Verification	Bcl-2 Family	Cancer
TCPOBOP is a constitutive androstane receptor (CAR) agonist that induces robust hepatocyte proliferation and hepatomegaly without any liver injury or tissue loss . TCPOBOP attenuates Fas-induced murine liver injury by altering *Bcl-2* proteins .

HY-112416

AZD4320 1 Publications Verification	Bcl-2 Family	Cancer
AZD4320 is a novel BH3-mimicking dual *BCL2/BCLxL* inhibitor with IC₅₀s of 26 nM, 17 nM, and 170 nM for KPUM-MS3, KPUM-UH1, and STR-428 cells, respectively.

HY-155188

NWP-0476	Bcl-2 Family	Neurological Disease
NWP-0476 is BCL-2/BCL-xL inhibitor. NWP-0476 has a modified structure with fine-tuned BCL-xL activity. NWP-0476 can be used for relapsed T-acute lymphoblastic leukemia (T-ALL) research .

HY-149681

Beclin1-Bcl-2 interaction inhibitor 1	Bcl-2 Family Beclin1	Cancer
Beclin1-Bcl-2 interaction inhibitor 1 potently inhibits Beclin 1/Bcl-2 binding. Beclin1-Bcl-2 interaction inhibitor 1 can be used for the research of cancer and neurodegeneration .

HY-162148

HNPMI	EGFR	Cancer
HNPMI is an inhibitor of EGFR and has cytotoxic effects on tumor cells. HNPMI can downregulate the protein levels of osteopontin, survivin and cathepsin S, leading to apoptosis. HNPMI also regulates BCL-2/BAX and p53 in CRC cell lines to inhibit tumorigenesis .

HY-12011

HA14-1 1 Publications Verification	Bcl-2 Family	Cancer
HA14-1 is a *Bcl-2/Bcl-X_L* antagonist. HA14-1 binds the designated pocket on Bcl-2 with the IC₅₀ of ≈9 μM in competing with the Bcl-2 binding of Flu-BakBH3, and inhibits its function.

HY-147929

Apoptotic agent-3	Apoptosis Caspase Bcl-2 Family	Cancer
Apoptotic agent-3 (compound 15f) promotes apoptosis through the potential mitochondria-mediated Bcl-2/Bax pathway and activation of the Caspase 3 pathway. Apoptotic agent-3 exhibits anti-proliferative activities and can be used for cancer research .

HY-120882

BM-1197 UBX1967	Bcl-2 Family	Cancer
BM-1197 (UBX1967) is a potent and selective inhibitor of dual *Bcl-2/Bcl-xL, with IC₅₀*s of 3.5 nM and 5.2 nM for Bcl-2 and Bcl-xL, respectively. BM-1197 exhibits antitumor effects both in vitro and in vivo .

HY-157343

GD3 Ganglioside	Apoptosis	Neurological Disease Cancer
GD3 Ganglioside is a prominent ganglioside of human melanoma. GD3 Ganglioside is an inducer of mitochondrial permeability. GD3 ganglioside directly targets mitochondria in a bcl-2-controlled fashion. GD3 ganglioside is rapidly synthesized from accumulated ceramide after the clustering of death-inducing receptors and triggers apoptosis .

HY-10969

Obatoclax Mesylate 5+ Cited Publications GX15-070 Mesylate	Bcl-2 Family Autophagy Parasite	Infection Cancer
Obatoclax Mesylate (GX15-070 Mesylate), a BH3 mimetic, is a pan-BCL-2 family proteins inhibitor with a K_i of 220 nM for BCL-2 . Obatoclax Mesylate induces autophagy-dependent cell death and targets cyclin D1 for proteasomal degradation. Obatoclax Mesylate has anti-cancer and broad-spectrum antiparasitic activity .

HY-10969A

Obatoclax GX15-070	Bcl-2 Family Autophagy Parasite	Infection Cancer
Obatoclax (GX15-070), a BH3 mimetic, is a pan-BCL-2 family proteins inhibitor with a K_i of 220 nM for BCL-2 . Obatoclax induces autophagy-dependent cell death and targets cyclin D1 for proteasomal degradation. Obatoclax has anti-cancer and broad-spectrum antiparasitic activity .

HY-144778

IDO1/TDO-IN-1	Indoleamine 2,3-Dioxygenase (IDO) Apoptosis Bcl-2 Family	Cancer
IDO1/TDO-IN-1 (30) is a potent dual IDO1 (uncompetitive, K_i of 0.23 μM) and TDO (competitive, K_i of 0.73 μM) inhibitor. IDO1/TDO-IN-1 (30) significantly promotes cell apoptosis through the potential mitochondria-mediated Bcl-2/Bax pathway .

HY-N0265

Asperosaponin VI 1 Publications Verification	Caspase Apoptosis	Cardiovascular Disease
Asperosaponin VI, A saponin component from Dipsacus asper, induces osteoblast differentiation through BMP‐2/p38 and ERK1/2 pathway . Asperosaponin Ⅵ inhibits apoptosis in hypoxia-induced cardiomyocyte by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing of p-Akt and p-CREB .

HY-156278

FB49	Apoptosis Autophagy	Cancer
FB49 is a highly selective inhibitor of Bcl-2-associated athanogene 3 (BAG3), with the K_i of 45 μM. FB49 inhibits the cell growth in human tumoral cells, but has no toxicity in human peripheral mononuclear cells. FB49 block cell cycle in G1 phase and to induce apoptosis as well as autophagy in medulloblastoma HD-MB03 treated cells .

HY-13846

BM-1074	Bcl-2 Family Apoptosis	Cancer
BM-1074 is a potent and specific *Bcl-2/Bcl-xL* inhibitor with K_i values of < 1 nM and IC₅₀ values of 1.8 nM and 6.9 nM for Bcl-2 and Bcl-xL, respectively. BM-1074 induces apoptosis, and exhibits antiproliferative activity against four small-cell lung cancer cell lines (H146, H1963, H187 and H1417) with IC₅₀ values of 1-2 nM .

HY-50907

ABT-737 Maximum Cited Publications 36 Publications Verification	Bcl-2 Family Apoptosis Autophagy Mitophagy	Cancer
ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-x_L and Bcl-w inhibitor with EC₅₀s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia (AML) research .

HY-132307

Mcl-1 inhibitor 6	Bcl-2 Family Apoptosis	Cancer
Mcl-1 inhibitor 6 is an orally active, selective myeloid cell leukemia 1 (Mcl-1) protein inhibitor with a K_d of 0.23 nM and a K_i of 0.02 μM. Mcl-1 inhibitor 6 possesses superior selectivity over other Bcl-2 family members (Bcl-2, Bcl2A1, Bcl-xL, and Bcl-w, K_d>10 μM). Mcl-1 inhibitor 6 is a potent antitumor agent .

HY-143235

BRD4 Inhibitor-15	Epigenetic Reader Domain Apoptosis Bcl-2 Family Caspase c-Myc	Cancer
BRD4 Inhibitor-15 (compound 13) is a potent BRD4 inhibitor, with an IC₅₀ of 18 nM. BRD4 Inhibitor-15 induces apoptosis of 22RV1 cells by regulating *Bcl-2/Bax* proteins and activating caspase-3 signaling pathway. BRD4 Inhibitor-15 down-regulates the c-Myc level in 22RV1 cells. BRD4 Inhibitor-15 can be used for prostate cancer research .

HY-50907S

ABT-737-d8	Biochemical Assay Reagents	Cancer
ABT 737-d₈ is the deuterium labeled ABT-737. ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-x_L and Bcl-w inhibitor with EC₅₀s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia (AML) research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-119931

2-Hydroxychalcone	Structural Classification Chalcones Monophenols Flavonoids Classification of Application Fields Source classification Phenols Metabolic Disease Endogenous metabolite Disease Research Fields	Bcl-2 Family Apoptosis NF-κB Parasite
2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB .

HY-N0265

Asperosaponin VI 1 Publications Verification	Cardiovascular Disease Triterpenes Classification of Application Fields Terpenoids Dipsacaceae Source classification Plants Dipsacus asper Disease Research Fields	Caspase Apoptosis
Asperosaponin VI, A saponin component from Dipsacus asper, induces osteoblast differentiation through BMP‐2/p38 and ERK1/2 pathway . Asperosaponin Ⅵ inhibits apoptosis in hypoxia-induced cardiomyocyte by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing of p-Akt and p-CREB .

Cat. No.	Product Name	Chemical Structure

HY-50907S

ABT-737-d8
ABT 737-d₈ is the deuterium labeled ABT-737. ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-x_L and Bcl-w inhibitor with EC₅₀s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia (AML) research .

ABT-737-d8

ABT 737-d₈ is the deuterium labeled ABT-737. ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-x_L and Bcl-w inhibitor with EC₅₀s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia (AML) research .

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