Search Result

Isoforms Recommended:	Bcl-xL

Results for "

Bcl-xL

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bcl-2 Family (58) ADC Cytotoxin (1) Akt (2) Apoptosis (37) Autophagy (6) Beta-lactamase (1) Biochemical Assay Reagents (1) Caspase (2) COX (1) DNA/RNA Synthesis (1) Drug-Linker Conjugates for ADC (1) E1/E2/E3 Enzyme (1) E3 Ligase Ligand-Linker Conjugates (5) Endogenous Metabolite (4) Fatty Acid Synthase (FASN) (2) HDAC (2) Isotope-Labeled Compounds (2) Ligands for E3 Ligase (2) Ligands for Target Protein for PROTAC (3) MDM-2/p53 (3) Microtubule/Tubulin (5) Mitophagy (1) P-glycoprotein (1) PARP (1) PDHK (2) PGE synthase (1) Phosphatase (1) PI3K (1) PIKfyve (1) PKC (2) PROTAC Linkers (1) PROTACs (8) RAR/RXR (1) Reactive Oxygen Species (1) TAM Receptor (1) TRP Channel (1)
By Research Areas:	Cancer (86) Cardiovascular Disease (1) Inflammation/Immunology (10) Metabolic Disease (5) Neurological Disease (4)

By Targets:

Bcl-2 Family (58)

ADC Cytotoxin (1)

Akt (2)

Apoptosis (37)

Autophagy (6)

Beta-lactamase (1)

Biochemical Assay Reagents (1)

Caspase (2)

COX (1)

DNA/RNA Synthesis (1)

Drug-Linker Conjugates for ADC (1)

E1/E2/E3 Enzyme (1)

E3 Ligase Ligand-Linker Conjugates (5)

Endogenous Metabolite (4)

Fatty Acid Synthase (FASN) (2)

HDAC (2)

Isotope-Labeled Compounds (2)

Ligands for E3 Ligase (2)

Ligands for Target Protein for PROTAC (3)

MDM-2/p53 (3)

Microtubule/Tubulin (5)

Mitophagy (1)

P-glycoprotein (1)

PARP (1)

PDHK (2)

PGE synthase (1)

Phosphatase (1)

PI3K (1)

PIKfyve (1)

PKC (2)

PROTAC Linkers (1)

PROTACs (8)

RAR/RXR (1)

Reactive Oxygen Species (1)

TAM Receptor (1)

TRP Channel (1)

By Research Areas:

Cancer (86)

Cardiovascular Disease (1)

Inflammation/Immunology (10)

Metabolic Disease (5)

Neurological Disease (4)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Bcl-2 Family BCL6

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12908

Bcl-xL antagonist 2
Bcl-xL antagonist 2 is a potent, selective, and orally active antagonist of *BCL-X_L* with an IC₅₀ and K_i of 0.091 μM and 65 nM, respectively. Bcl-xL antagonist 2 promotes the apoptosis of cancer cells. Bcl-xL antagonist 2 has the potential for the research of the chronic lymphocytic leukemia (CLL) and non-Hodgkin’s lymphoma (NHL) .

HY-139309

*PROTAC Bcl-xL* degrader-2**	Bcl-2 Family PROTACs	Cancer
PROTAC Bcl-xL degrader-2 is a potent *Bcl-xL* (Bcl-2 family member) degrader based on von Hippel-Lindau ligand, with an IC₅₀ of 0.6 nM.

HY-139304

PROTAC Bcl-xL ligand-1

Ligands for Target Protein for PROTAC Bcl-2 Family Cancer

PROTAC Bcl-xL ligand-1 is a ligand for Bcl-xL that can be used in the synthesis of PROTACs .

*PROTAC Bcl-xL* ligand-1**	Ligands for Target Protein for PROTAC Bcl-2 Family	Cancer
PROTAC Bcl-xL ligand-1 is a ligand for Bcl-xL that can be used in the synthesis of PROTACs .

HY-131188

*PROTAC Bcl-xL* degrader-1**	PROTACs Bcl-2 Family	Cancer
PROTAC Bcl-xL degrader-1 is a PROTAC that comprises a *Bcl-xL* (Bcl-2 family member) ligand binding group, a linker and an IAP E3 ligases binding group. PROTAC Bcl-xL degrader-1 is a potent *Bcl-xL* degrader, and shows toxicity for human platelets and MyLa 1929 cells with IC₅₀ values of 62 nM and 8.5 μM, respectively .

HY-132997

PROTAC Bcl-xL degrader-3

PROTACs Bcl-2 Family Cancer

PROTAC Bcl-xL degrader-3 is a potent ROTAC Bcl-xL degrader (WO2020163823A2, compound 44) .

*PROTAC Bcl-xL* degrader-3**	PROTACs Bcl-2 Family	Cancer
PROTAC Bcl-xL degrader-3 is a potent ROTAC Bcl-xL degrader (WO2020163823A2, compound 44) .

HY-P5320

*TAT-BH4 (Bcl-xL)*	Apoptosis	Others
TAT-BH4 (Bcl-xL) localized mainly at the mitochondria, prevents apoptotic cell death. TAT-BH4 (Bcl-xL) is a fusion peptide that combines the N-terminal cysteine conjugated protein transduction domain of HIV TAT protein (amino acids 49 to 57) with the Bcl-xL BH4 peptide. TAT-BH4 can be used for research of diseases caused by accelerated apoptosis .

HY-P5320A

*TAT-BH4 (Bcl-xL) (TFA)*	Apoptosis	Others
TAT-BH4 (Bcl-xL) TFA is localized mainly at the mitochondria, prevents apoptotic cell death. TAT-BH4 (Bcl-xL) is a fusion peptide that combines the N-terminal cysteine conjugated protein transduction domain of HIV TAT protein (amino acids 49 to 57) with the Bcl-xL BH4 peptide. TAT-BH4 TFA can be used for research of diseases caused by accelerated apoptosis .

HY-129179

Lisaftoclax APG-2575; Bcl-2/Bcl-xL inhibitor 1	Bcl-2 Family	Cancer
Lisaftoclax (compound 6) is a dual *Bcl-2* and *Bcl-xl* inhibitor with anti-tumor activity, extracted from patent WO2018027097A1. Lisaftoclax exhibits IC₅₀ values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively .

HY-120882

BM-1197 UBX1967	Bcl-2 Family	Cancer
BM-1197 (UBX1967) is a potent and selective inhibitor of dual *Bcl-2/Bcl-xL, with IC₅₀s of 3.5 nM and 5.2 nM for Bcl-2 and Bcl-xL*, respectively. BM-1197 exhibits antitumor effects both in vitro and in vivo .

HY-109185

Pelcitoclax

APG-1252
Bcl-2 Family Apoptosis Cancer

Pelcitoclax (APG-1252) is a potent Bcl-2/Bcl-xl inhibitor with antineoplastic and pro-apoptotic effects .
HY-130640

(S,R,S)-AHPC-Me-C7 ester

E3 Ligase Ligand-Linker Conjugates Cancer

(S,R,S)-AHPC-Me-C7 ester is a E3 ligase ligand-linker conjugate used to synthesise BCL-X_L PROTAC degraders .
HY-16014

A-385358

Bcl-2 Family Cancer

A-385358 is a selective inhibitor of Bcl-X_L with K_is of 0.80 and 67 nM for Bcl-X_L and Bcl-2, respectively.

Pelcitoclax APG-1252	Bcl-2 Family Apoptosis	Cancer
Pelcitoclax (APG-1252) is a potent *Bcl-2/Bcl-xl* inhibitor with antineoplastic and pro-apoptotic effects .

(S,R,S)-AHPC-Me-C7 ester	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-Me-C7 ester is a E3 ligase ligand-linker conjugate used to synthesise *BCL-X_L* PROTAC degraders .

A-385358	Bcl-2 Family	Cancer
A-385358 is a selective inhibitor of *Bcl-X_L* with K_is of 0.80 and 67 nM for *Bcl-X_L* and *Bcl-2*, respectively.

HY-115718A

PZ703b TFA 1 Publications Verification	PROTACs Bcl-2 Family	Cancer
PZ703b TFA is a Bcl-xl PROTAC degradation agent that induces apoptosis and inhibits cancer cell proliferation for bladder cancer research .

HY-W016087

Monoethyl pimelate	PROTAC Linkers	Cancer
Monoethyl pimelate is a PROTAC linker, which refers to the alkyl/ether composition. Monoethyl pimelate can be used in the synthesis of (S,R,S)-AHPC-Me-C7 ester, a specific BCL-X_L PROTAC degrader .

HY-150266

A-1293102

Bcl-2 Family Cancer

A-1293102 is a potent and selective BCL-XL inhibitor that kills BCL-XL-dependent tumor cells .

A-1293102	Bcl-2 Family	Cancer
A-1293102 is a potent and selective *BCL-XL* inhibitor that kills BCL-XL-dependent tumor cells .

HY-130604

DT2216 1 Publications Verification	Bcl-2 Family PROTACs Apoptosis	Cancer
DT2216 is a potent and selective *BCL-XL* (Bcl-2 family member) degrader based on PROTAC technology. DT2216 causes effective degradation of BCL-XL protein by recruiting Von Hippel-Lindau (VHL) E3 ubiquitin ligase. DT2216 inhibits various BCL-XL-dependent leukemia and cancer cells but considerably less toxic to platelets. DT2216 is composed of the Bcl-2 family protein inhibitor Navitoclax (HY-10087), a linker, and a VHL E3 ubiquitin ligase (Red: Navitoclax; Blue: VHL ligand; Black: linker) .

HY-13846

BM-1074	Bcl-2 Family Apoptosis	Cancer
BM-1074 is a potent and specific *Bcl-2/Bcl-xL* inhibitor with K_i values of < 1 nM and IC₅₀ values of 1.8 nM and 6.9 nM for Bcl-2 and Bcl-xL, respectively. BM-1074 induces apoptosis, and exhibits antiproliferative activity against four small-cell lung cancer cell lines (H146, H1963, H187 and H1417) with IC₅₀ values of 1-2 nM .

HY-133799

Pomalidomide-C7-COOH	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-C7-COOH is a synthesized E3 ligase cereblon ligand-linker conjugate. Pomalidomide-C7-COOH is an intermediate for the synthesis of PROTAC BCL-XL degraders .

HY-131232

Desmorpholinyl Navitoclax-NH-Me Desmorpholinyl ABT-263-NH-Me	Bcl-2 Family Ligands for Target Protein for PROTAC	Cancer
Desmorpholinyl Navitoclax-NH-Me is a *Bcl-xL* inhibitor. Desmorpholinyl Navitoclax-NH-Me and a CRBN ligand for the E3 ubiquitin ligase can be used in the synthesis of PROTAC BCL-XL degrader XZ739 (HY-133557) .

HY-131247

Bcl-2-IN-2	Bcl-2 Family	Inflammation/Immunology Cancer
Bcl-2-IN-2 is a potent and selective *Bcl-2* inhibitor with an IC₅₀ of 0.034 nM and also inhibits Bcl-xL with an IC₅₀ of 43 nM, showing >1000-fold selectivity for Bcl-2 over Bcl-xL .

HY-15607A

WEHI-539 hydrochloride

20+ Cited Publications

Bcl-2 Family Cancer

WEHI-539 hydrochloride is a selective inhibitor of Bcl-XL with an IC₅₀ of 1.1 nM.
HY-15607

WEHI-539

Bcl-2 Family Cancer

WEHI-539 is a selective inhibitor of Bcl-XL with an IC₅₀ of 1.1 nM.

WEHI-539 hydrochloride 20+ Cited Publications	Bcl-2 Family	Cancer
WEHI-539 hydrochloride is a selective inhibitor of *Bcl-XL* with an IC₅₀ of 1.1 nM.

WEHI-539	Bcl-2 Family	Cancer
WEHI-539 is a selective inhibitor of *Bcl-XL* with an IC₅₀ of 1.1 nM.

HY-155188

NWP-0476	Bcl-2 Family	Neurological Disease
NWP-0476 is BCL-2/BCL-xL inhibitor. NWP-0476 has a modified structure with fine-tuned BCL-xL activity. NWP-0476 can be used for relapsed T-acute lymphoblastic leukemia (T-ALL) research .

HY-150069

UBX1325	Bcl-2 Family Apoptosis	Metabolic Disease
UBX1325 is an *Bcl-xL* inhibitor that promotes apoptosis in senescent cells. UBX1325 is a potent anti-aging agent that can be used in studies of age-related eye diseases such as diabetic macular oedema (DME), age-related macular degeneration (AMD) and diabetic retinopathy (DR) .

HY-19741

A-1331852

25+ Cited Publications

Bcl-2 Family Cancer

A-1331852 is an orally available BCL-XL selective inhibitor with a K_i of less than 10 pM.

A-1331852 25+ Cited Publications	Bcl-2 Family	Cancer
A-1331852 is an orally available *BCL-XL* selective inhibitor with a K_i of less than 10 pM.

HY-P2468

BAD (103-127) (human) BADBH3 103-127 (human); BADBH3 (human)	Bcl-2 Family	Cancer
BAD (103-127) (human), the 25-mer Bad peptide, is derived from the BH3 domain of BAD, can antagonize the function of *Bcl-xL. BAD (103-127) (human) is reported to have almost 800-fold higher affinity for Bcl-XL* than the 16-mer peptide .

HY-131189

N-Boc-SBP-0636457-OH	Ligands for E3 Ligase	Cancer
N-Boc-SBP-0636457-OH, a ligand for E3 ubiquitin ligase, is used in the recruitment of IAP E3 ligases. N-Boc-SBP-0636457-OH can be connected to the ligand for Bcl-xL by a linker to form PROTAC Bcl-xL degrader-1 (HY-131188).

HY-P0300

Bak BH3

Bcl-2 Family Cancer

Bak BH3 is derived from the BH3 domain of Bak, can antagonize the function of Bcl-xL in cells.

Bak BH3	Bcl-2 Family	Cancer
Bak BH3 is derived from the BH3 domain of Bak, can antagonize the function of *Bcl-xL* in cells.

HY-137774

Clezutoclax	ADC Cytotoxin Bcl-2 Family Drug-Linker Conjugates for ADC	Cancer
Clezutoclax is a potent payload and also a Bcl-XL inhibitor. Clezutoclax can be used in the synthesis of antibody-drug conjugates (ADCs) .

HY-12048

Chelerythrine chloride 10+ Cited Publications	PKC Bcl-2 Family Apoptosis Autophagy	Metabolic Disease Inflammation/Immunology Cancer
Chelerythrine chloride is a potent, cell-permeable inhibitor of protein kinase C, with an IC₅₀ of 660 nM. Chelerythrine chloride inhibits the Bcl-XL-Bak BH3 peptide binding with IC₅₀ of 1.5 μM and displaces Bax from Bcl-XL. Chelerythrine chloride induces apoptosis and autophagy.

HY-P99360

Enapotamab Anti-AxL/UFO Reference Antibody (enapotamab)	TAM Receptor	Cancer
Enapotamab is an anti-AXL/UFO reference antibody. Enapotamab can be used to synthesis Bcl-xl inhibitor antibody-drug conjugates .

HY-117585

Caylin-2

MDM-2/p53 Cancer

Caylin-2, a Nutlin-3 analog, is a MDM2 inhibitor. Caylin-2 can bind to Bcl-X_L .
HY-13407

Gossypol

3 Publications Verification

BL 193
Bcl-2 Family Cancer

Gossypol binds to Bcl-xL protein and Bcl-2 protein with K_is of 0.5-0.6 μM and 0.2-0.3 mM, respectively.
HY-12020

TW-37

2 Publications Verification

Bcl-2 Family Cancer

TW-37 is a potent Bcl-2 inhibitor with K_i values of 260, 290 and 1110 nM for Mcl-1, Bcl-2 and Bcl-xL, respectively.
HY-18106

BM 957

Bcl-2 Family Cancer

BM 957 is a potent Bcl-2 and Bcl-xL inhibitor, with K_is of 1.2, <1 nM and IC₅₀s of 5.4, 6.0 nM respectively.

Caylin-2	MDM-2/p53	Cancer
Caylin-2, a Nutlin-3 analog, is a MDM2 inhibitor. Caylin-2 can bind to Bcl-X_L .

Gossypol 3 Publications Verification BL 193	Bcl-2 Family	Cancer
Gossypol binds to *Bcl-xL* protein and *Bcl-2* protein with K_is of 0.5-0.6 μM and 0.2-0.3 mM, respectively.

TW-37 2 Publications Verification	Bcl-2 Family	Cancer
TW-37 is a potent *Bcl-2* inhibitor with K_i values of 260, 290 and 1110 nM for Mcl-1, *Bcl-2* and *Bcl-xL*, respectively.

BM 957	Bcl-2 Family	Cancer
BM 957 is a potent Bcl-2 and Bcl-xL inhibitor, with K_is of 1.2, <1 nM and IC₅₀s of 5.4, 6.0 nM respectively.

HY-P3560

Edratide TV 4710	Apoptosis	Inflammation/Immunology
Edratide (TV 4710) is a synthetic peptide of 19 amino acid based on the complementarity-determining region 1 (CDR1) of a human anti-DNA antibody that expresses a major idiotype denoted 16/6 Id. Edratide reduces the rates of apoptosis (Apoptosis) and down-regulates of caspase-8 and caspase-3, up-regulates Bcl-xL. Edratide has the potential for the research of systemic lupus erythematosus (SLE) .

HY-146097

RMS5	P-glycoprotein Apoptosis	Cancer
RMS5, a tetrandrine analogue, is a potent P-glycoprotein (P-gp) inhibitor. RMS5 has markedly antiproliferative and cytotoxic effects on cancer cells. RMS5 slightly diminishes the expression of the anti-apoptotic Bcl-2 family proteins Bcl-XL and Mcl-1. RMS3 causes PARP cleavage, a marker for cells undergoing apoptosis. RMS5 has strong anticancer property .

HY-15613

Maritoclax 5 Publications Verification Marinopyrrole A	Bcl-2 Family	Cancer
Maritoclax (Marinopyrrole A) is a novel and specific Mcl-1 inhibitor with an IC₅₀ value of 10.1 μM, and shows >8 fold selectivity than BCL-xl (IC₅₀ > 80 μM).

HY-17510

Gossypol (acetic acid) 3 Publications Verification (±)-Gossypol-acetic acid; BL-193 (acetic acid)	Bcl-2 Family	Cancer
Gossypol acetic acid ((±)-Gossypol-acetic acid) binds to *Bcl-xL* protein and *Bcl-2* protein with K_is of 0.5-0.6 μM and 0.2-0.3 mM, respectively.

HY-15464D

(S)-Gossypol (acetic acid) 1 Publications Verification (S)-(+)-Gossypol acetic acid	Bcl-2 Family	Cancer
(S)-Gossypol is the isomer of a natural product Gossypol. (S)-Gossypol binds to the BH3-binding groove of *Bcl-xL* and *Bcl-2* proteins with high affinity.

HY-N2897

Dihydrokaempferol	Apoptosis Bcl-2 Family	Inflammation/Immunology
Dihydrokaempferol is isolated from Bauhinia championii (Benth). Dihydrokaempferol induces apoptosis and inhibits Bcl-2 and Bcl-xL expression. Dihydrokaempferol is a good candidate for new antiarthritic agents .

HY-103256

2,3-DCPE

Apoptosis Cancer

2,3-DCPE induces apoptosis and downregulates Bcl-XL expression. 2,3-DCPE has anti-tumor activity and can be used in cancer research .

2,3-DCPE	Apoptosis	Cancer
2,3-DCPE induces apoptosis and downregulates Bcl-XL expression. 2,3-DCPE has anti-tumor activity and can be used in cancer research .

HY-110027

2,3-DCPE hydrochloride	Apoptosis	Cancer
2,3-DCPE hydrochloride induces apoptosis and downregulates *Bcl*-XL expression. 2,3-DCPE hydrochloride has anti-tumor activity and can be used in cancer research .

HY-115718

PZ703b 1 Publications Verification	PROTACs Bcl-2 Family	Cancer
PZ703b is a Bcl-xl PROTAC degrader that induces apoptosis and inhibits cancer cell proliferation. PZ703b can be used for the research of bladder cancer research .

HY-115718B

PZ703b hydrochloride 1 Publications Verification	PROTACs Apoptosis Bcl-2 Family	Cancer
PZ703b hydrochloride is a Bcl-xl PROTAC degrader that induces apoptosis and inhibits cancer cell proliferation. PZ703b hydrochloride can be used for the research of bladder cancer research .

HY-120520

Caylin-1

Ligands for E3 Ligase Cancer

Caylin-1 is an inhibitor of MDM2 and an analog of Nutlin-3. Caylin-1 can bind to Bcl-XL and is used in multi-target anticancer research .
HY-161100

BDM19

Apoptosis Cancer

BDM19 binds and activates cytosolic BAX dimers, and prompts cell apoptosis either alone or in combination with BCL-2/BCL-XL inhibitor Navitoclax (HY-10087) .

Caylin-1	Ligands for E3 Ligase	Cancer
Caylin-1 is an inhibitor of MDM2 and an analog of Nutlin-3. Caylin-1 can bind to Bcl-XL and is used in multi-target anticancer research .

HY-13408

(+)-Apogossypol Apogossypol; NSC736630	Bcl-2 Family	Cancer
(+)-Apogossypol is a *pan-BCL-2* antagonist. (+)-Apogossypol binds to Mcl-1, *Bcl-2* and *Bcl-xL* with EC₅₀s of 2.6, 2.8 and 3.69 µM, respectively.

HY-131998

Thalidomide-NH-PEG4-Ms	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide-NH-PEG4-Ms is an E3 ligase ligand-linker conjugate that incorporates Thalidomide based cereblon ligand and a linker used for PROTAC BCL-XL degrader XZ739 .

HY-153953

Bcl-2-IN-11	Bcl-2 Family	Cancer
Bcl-2-IN-11 (compound 6) is a potent and selective *Bcl-2* activity inhibitor, with an IC₅₀ of 0.9 nM. Bcl-2-IN-11 shows weak inhibition of Bcl-xl (IC₅₀ > 1000 nM). Bcl-2-IN-11 can be used for the research of a variety of cancers caused by abnormal overexpression of Bcl-2 family proteins: especially malignant hematologic diseases of acute lymphoid leukemia, etc. Bcl-2-IN-11 can also avoid toxic side effects caused by Bcl-xl inhibition, such as thrombocytopenia .

Cat. No.	Product Name	Target	Research Area

HY-P2468

BAD (103-127) (human) BADBH3 103-127 (human); BADBH3 (human)	Bcl-2 Family	Cancer
BAD (103-127) (human), the 25-mer Bad peptide, is derived from the BH3 domain of BAD, can antagonize the function of *Bcl-xL. BAD (103-127) (human) is reported to have almost 800-fold higher affinity for Bcl-XL* than the 16-mer peptide .

HY-P3560

Edratide TV 4710	Apoptosis	Inflammation/Immunology
Edratide (TV 4710) is a synthetic peptide of 19 amino acid based on the complementarity-determining region 1 (CDR1) of a human anti-DNA antibody that expresses a major idiotype denoted 16/6 Id. Edratide reduces the rates of apoptosis (Apoptosis) and down-regulates of caspase-8 and caspase-3, up-regulates Bcl-xL. Edratide has the potential for the research of systemic lupus erythematosus (SLE) .

HY-P5320

*TAT-BH4 (Bcl-xL)*	Apoptosis	Others
TAT-BH4 (Bcl-xL) localized mainly at the mitochondria, prevents apoptotic cell death. TAT-BH4 (Bcl-xL) is a fusion peptide that combines the N-terminal cysteine conjugated protein transduction domain of HIV TAT protein (amino acids 49 to 57) with the Bcl-xL BH4 peptide. TAT-BH4 can be used for research of diseases caused by accelerated apoptosis .

HY-P5320A

*TAT-BH4 (Bcl-xL) (TFA)*	Apoptosis	Others
TAT-BH4 (Bcl-xL) TFA is localized mainly at the mitochondria, prevents apoptotic cell death. TAT-BH4 (Bcl-xL) is a fusion peptide that combines the N-terminal cysteine conjugated protein transduction domain of HIV TAT protein (amino acids 49 to 57) with the Bcl-xL BH4 peptide. TAT-BH4 TFA can be used for research of diseases caused by accelerated apoptosis .

HY-P0300

Bak BH3

Bcl-2 Family Cancer

Bak BH3 is derived from the BH3 domain of Bak, can antagonize the function of Bcl-xL in cells.

HY-P2499

BAD (103-127) (human), FAM-labeled	Bcl-2 Family	Cancer
BAD (103-127) (human), FAM-labeled is a FAM-labeled human BAD (103-127) (HY-P2468). BAD (103-127) (human), the 25-mer Bad peptide, is derived from the BH3 domain of BAD, can antagonize the function of Bcl-xL .

HY-P2343

BH3 hydrochloride	Apoptosis	Cancer
BH3 hydrochloride, a BBB penetrated peptide, provoke apoptosis either by direct activation of pro-apoptotic Bax/Bak or by neutralizing anti-apoptotic Bcl-2 proteins (Bcl-2, Bcl-XL, Bcl-w, Mcl-1 and A-1) via their BH3 domian .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-12048

Chelerythrine chloride 10+ Cited Publications	Alkaloids Structural Classification Classification of Application Fields Chelidonium majus Source classification Metabolic Disease Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Papaveraceae	PKC Bcl-2 Family Apoptosis Autophagy
Chelerythrine chloride is a potent, cell-permeable inhibitor of protein kinase C, with an IC₅₀ of 660 nM. Chelerythrine chloride inhibits the Bcl-XL-Bak BH3 peptide binding with IC₅₀ of 1.5 μM and displaces Bax from Bcl-XL. Chelerythrine chloride induces apoptosis and autophagy.

HY-13407

Gossypol 3 Publications Verification BL 193	Malvaceae Classification of Application Fields Source classification Phenols Polyphenols Gossypium herbaceum Linn. Plants Disease Research Fields Cancer	Bcl-2 Family
Gossypol binds to *Bcl-xL* protein and *Bcl-2* protein with K_is of 0.5-0.6 μM and 0.2-0.3 mM, respectively.

HY-17510

Gossypol (acetic acid) 3 Publications Verification (±)-Gossypol-acetic acid; BL-193 (acetic acid)	other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Bcl-2 Family
Gossypol acetic acid ((±)-Gossypol-acetic acid) binds to *Bcl-xL* protein and *Bcl-2* protein with K_is of 0.5-0.6 μM and 0.2-0.3 mM, respectively.

HY-N2897

Dihydrokaempferol	Flavanonols Structural Classification Flavonoids Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Bauhinia championii (Benth.) Benth. Plants Inflammation/Immunology Disease Research Fields	Apoptosis Bcl-2 Family
Dihydrokaempferol is isolated from Bauhinia championii (Benth). Dihydrokaempferol induces apoptosis and inhibits Bcl-2 and Bcl-xL expression. Dihydrokaempferol is a good candidate for new antiarthritic agents .

HY-15464

(R)-(-)-Gossypol 2 Publications Verification AT-101; R-(-)-gossypol acetic acid	Malvaceae Structural Classification Classification of Application Fields Gossypium Source classification Phenols Plants Disease Research Fields Cancer	Bcl-2 Family Autophagy
(R)-(-)-Gossypol (AT-101) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to *Bcl-2, Mcl-1* and *Bcl-xL* proteins with K_is of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.

HY-B0011

Docetaxel Maximum Cited Publications 81 Publications Verification RP-56976	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Microtubule/Tubulin Apoptosis Endogenous Metabolite
Docetaxel (RP-56976) is a microtubule depolymerization inhibitor, with an IC₅₀ of 0.2 μM. Docetaxel attenuates the effects of bcl-2 and *bcl-xL* gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity .

HY-B0011R

Docetaxel (Standard) RP-56976 (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Microtubule/Tubulin Apoptosis Endogenous Metabolite
Docetaxel (Standard) is the analytical standard of Docetaxel. This product is intended for research and analytical applications. Docetaxel (RP-56976) is a microtubule depolymerization inhibitor, with an IC₅₀ of 0.2 μM. Docetaxel attenuates the effects of bcl-2 and *bcl-xL* gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity .

HY-N0087

Gambogic Acid 2 Publications Verification Beta-Guttiferrin	Structural Classification Natural Products Classification of Application Fields Guttiferae Plants Garcinia hanburyi Hook. f. Disease Research Fields Cancer	Bcl-2 Family Autophagy
Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits *Bcl-X_L, Bcl-2, Bcl-W, Bcl-B, Bfl-1* and Mcl-1 with IC₅₀s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.

HY-N0361

Dihydrocapsaicin 1 Publications Verification	Alkaloids Structural Classification Monophenols Capsicum annuum L. Classification of Application Fields Source classification Phenols Metabolic Disease Plants Solanaceae Disease Research Fields	TRP Channel Reactive Oxygen Species Apoptosis Caspase Bcl-2 Family Akt PI3K
Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased *Bcl-2, Bcl-xL* and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat .

HY-N2359

Chelerythrine	Alkaloids Structural Classification Classification of Application Fields Source classification Metabolic Disease Macleaya cordata (Willd.) R. Br. Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Papaveraceae	Beta-lactamase PKC Bcl-2 Family Apoptosis Autophagy
Chelerythrine is a natural alkaloid, acts as a potent and selective Ca ²⁺/phospholopid-dependent PKC antagonist, with an IC₅₀ of 0.7 μM . Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity . Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with IC₅₀ of 1.5 μM and displaces Bax from BclXL. Chelerythrine triggers apoptosis and autophagy .

HY-15128

9-cis-Retinoic acid Alitretinoin	Structural Classification Classification of Application Fields Terpenoids Source classification Diterpenoids Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	RAR/RXR Apoptosis Endogenous Metabolite
9-cis-Retinoic acid (ALRT1057), a vitamin A derivative, is a potent RAR/RXR agonist. 9-cis-Retinoic acid induces apoptosis, regulates cell cycle and has anticancer, anti-inflammatory and neuroprotection activities .

Cat. No.	Product Name	Chemical Structure

HY-10087S

Navitoclax-d8
Navitoclax-d₈ is the deuterium labeled Navitoclax. Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM[1].

HY-B0011S

Docetaxel-d9
Docetaxel-d₉ is the deuterium labeled Docetaxel. Docetaxel (RP-56976) is a microtubule depolymerization inhibitor, with an IC50 of 0.2 μM. Docetaxel attenuates the effects of bcl-2 and bcl-xL gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity[1][3].

HY-N0361S

Dihydrocapsaicin-d3

Dihydrocapsaicin-d₃is the deuterium labeledDihydrocapsaicin(HY-N0361) . Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat .

HY-50907S

ABT-737-d8

ABT 737-d₈ is the deuterium labeled ABT-737. ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-x_L and Bcl-w inhibitor with EC₅₀s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia (AML) research .

HY-B0011AS

Docetaxel-d5 trihydrate

Docetaxel-d₅ (trihydrate) is the deuterium labeled Docetaxel (Trihydrate). Docetaxel Trihydrate (RP-56976 Trihydrate) is an antineoplastic agent and inhibits microtubule depolymerization with an IC50 value of 0.2 μM[1]. Docetaxel Trihydrate is a semisynthetic analog of taxol and attenuates the effects of bcl-2 and bcl-xL gene expression. Docetaxel Trihydrate arrests the cell cycle at G2/M and leads to cell apoptosis[1][3].

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