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C.?albicans

" in MedChemExpress (MCE) Product Catalog:

49

Inhibitors & Agonists

1

Biochemical Assay Reagents

13

Peptides

11

Natural
Products

2

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-126396
    Sordarin sodium

    		CaMK Fungal Antibiotic Infection Inflammation/Immunology
    Sordarin is a potent diphthamide-dependent eEF2 inhibitor with antifungal properties. Sordarin targets eEF2 so as to inhibit protein translation by blocking eEF2-mediated translocation of tRNAs. Sordarin inhibits translation specifically in certain fungi (e.g. C. albicans, C. glabrata, and C. neoformans) while unable to do so in some other fungal species (e.g. Candida parapsilosis and Candida lusitaniae) .
    Sordarin sodium
  • HY-P5613
    XT-1

    		Bacterial Infection
    XT-1 is an antimicrobial peptide derived from skin secretions of Xenopus tropicalis. XT-1 has strong activity against S.aureus, E.coli and C.albicans, the vaule of MIC are 5, 6, 50 μM , respectively .
    XT-1
  • HY-P5632
    Bovine tracheal antimicrobial peptide

    		Bacterial Infection
    Bovine tracheal antimicrobial peptide is a kind of comes from the tracheal mucosa of antimicrobial peptides. Bovine tracheal antimicrobial peptide has activity against E.coli D31, K.pneumoniae 13883, S.aureus 25923, P.aeruginosa 27853 and C.albicans 14053, MIC value 12-25, 12-25, 25-50, 25-50, 6-12 μg/ml, respectively .
    Bovine tracheal antimicrobial peptide
  • HY-W142410
    2-Dodecanol

    		Fungal Others
    2-Dodecanol inhibits hyphal formation and SIR2 expression in C. albicans .
    2-Dodecanol
  • HY-P5565
    RP-1

    		Bacterial Infection
    RP-1 is an antimicrobial peptide, and is active against S. aureus, S. typhimurium, E. coli, and C. albicans .
    RP-1
  • HY-P3466
    Nisin Z

    		Bacterial Fungal Infection Inflammation/Immunology
    Nisin Z is an antimicrobial and anti-inflammatory peptide. Nisin Z is effective against Gram-positive bacteria and fungi, such as C. albicans .
    Nisin Z
  • HY-147238
    Antifungal agent 35

    		Fungal Infection
    Antifungal agent 35 (compound 24) is a potent antifungal agent. Antifungal agent 35 is a potent enhancer of antifungal activity of Fluconazole against C. albicans .
    Antifungal agent 35
  • HY-N6647
    Luteolin-7-rutinoside

    		Fungal Infection Inflammation/Immunology
    Luteolin-7-rutinoside has both anti-arthritic and antifungal activities, can result in a combination therapy for the treatment of fungal arthritis due to C. albicans infection.
    Luteolin-7-rutinoside
  • HY-N0334
    (+)-Magnoflorine

    Magnoflorine; α-Magnoflorine; Thalictrine

    		 Fungal Infection Metabolic Disease
    (+)-Magnoflorine (Magnoflorine), an aporphine alkaloid found in Acoruscalamus, reduces the formation of C. albicans biofilm . (+)-Magnoflorine has anti-fungal, anti-antidiabetic and anti-oxidative activity .
    (+)-Magnoflorine
  • HY-P5625
    ROAD-1

    		Bacterial Infection
    ROAD-1 is an oral mucosal α-defensin of Rhesus Macaque. ROAD-1 is active against S. aureus, E. coli, and C. albicans .
    ROAD-1
  • HY-N0535
    (+)-Magnoflorine chloride

    Magnoflorine chloride; α-Magnoflorine chloride; Thalictrine chloride

    		 Fungal Infection Metabolic Disease
    Magnoflorine chloride (Magnoflorine chloride), an aporphine alkaloid found in Magnolia or Aristolochia, reduces the formation of C. albicans biofilm . Magnoflorine chloride has anti-fungal, anti-antidiabetic and anti-oxidative activity .
    (+)-Magnoflorine chloride
  • HY-P5720
    Peptide 5e

    		Bacterial Infection
    Peptide 5e is an antimicrobial peptide. Peptide 5e inhibits E. coli, S. aureus, and C. albicans with MIC values of 30, 5, 25 μg/mL respectively .
    Peptide 5e
  • HY-106997
    Icofungipen

    BAY 10-8888; PLD 118

    		 Fungal Infection
    Icofungipen is an orally active antifungal agent. Icofungipen is the representative of beta amino acids, is toxic against Candida species. Icofungipen protects infected mice survival from C. albicans infection .
    Icofungipen
  • HY-P5730
    Peptide 5g

    		Bacterial Infection
    Peptide 5g is an antimicrobial peptide. Peptide 5g inhibits E. coli, S. aureus, and C. albicans with MIC values of 30, 10, 12.5 μg/mL respectively .
    Peptide 5g
  • HY-N0334A
    (+)-Magnoflorine iodide

    Magnoflorine iodide; α-Magnoflorine iodide; Thalictrine iodide

    		 Fungal Infection Metabolic Disease
    (+)-Magnoflorine iodide (Magnoflorine iodide), an aporphine alkaloid found in Acoruscalamus, reduces the formation of C. albicans biofilm . (+)-Magnoflorine iodide has anti-fungal, anti-antidiabetic and anti-oxidative activity .
    (+)-Magnoflorine iodide
  • HY-143334
    Antifungal agent 84

    		Fungal Infection
    Antibacterial agent 84 is an antifungal compound. Antibacterial agent 84 inhibits candidiasis in a CNB1-dependent way. Antibacterial agent 84 inhibits the C. albicans biofilm's viability .
    Antifungal agent 84
  • HY-P2148
    P-113

    		Bacterial Antibiotic Infection Inflammation/Immunology
    P-113 is an antimicrobial peptide (AMP) derived from the human salivary protein histatin 5. P-113 is active against clinically important microorganisms such as Pseudomonas spp., Staphylococcus spp., and C. albicans .
    P-113
  • HY-146023
    Antifungal agent 27

    		Bacterial Fungal Infection
    Antifungal agent 27 (compound 7) is a antifungal agent. Antifungal agent 27 shows moderate antibacterial and weak antifungal activities against MRSA and C. albicans SS5314, with MIC values of 8 and 32 μg/mL, respectively .
    Antifungal agent 27
  • HY-N11772
    Mutanocyclin

    		Fungal Infection
    Mutanocyclin is a potent antifungal agent. Mutanocyclin inhibits Candida albicans (C. albicans) filamentation. Mutanocyclin decreases the mRNA expression of HWP1, ECE1, FLO8, TEC1. Mutanocyclin inhibits yeast-form in ex vivo mouse .
    Mutanocyclin
  • HY-N10572
    Antibacterial synergist 2

    		Bacterial Infection
    Antibacterial synergist 2 (compound 27) is a biofilm inhibitor. Antibacterial synergist 2 shows inhibitory effects to S. enterica, S. aureus, P. aeruginosa and C. albicans. Antibacterial synergist 2 can be used for the research related to biofilm-forming pathogens .
    Antibacterial synergist 2
  • HY-121982
    Cyclo(L-Phe-L-Val)

    		Fungal Infection
    Cyclo(L-Phe-L-Val) is a potent inhibitor of enzymes isocitrate lyase (ICL) (IC50=27 μg/mL). cyclo(L-Phe-L-Val) inhibits the gene transcription of ICL in C. albicans under C2-carbon-utilizing conditions .
    Cyclo(L-Phe-L-Val)
  • HY-B0101
    Fluconazole
    5+ Cited Publications

    UK-49858

    		 Fungal Antibiotic Bacterial Infection Cancer
    Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candida albicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL .
    Fluconazole
  • HY-N3837
    Epitaraxerol

    Isotaraxerol; 3α-Taraxerol

    		 Others Infection
    Epitaraxerol (compound 6) is a natural product isolated from the leaves of E. neriifolia. Epitaraxerol shows moderate antifungal activity against C. albicans and low antimicrobial activity against T. mentagrophytes, A. niger, S. aureus, E. coli, P. aeruginosa, and B. subtilis .
    Epitaraxerol
  • HY-P5686
    Maximin 78

    		Bacterial Infection
    Maximin 78 is an antimicrobial peptide. Maximin 78 has antibacterial activity against C. albicans, S. aureus, B. subtilis (MIC: 37.5, 4.7, 37.5 μg/mL). Maximin 78 has hemolytic activities against human and rabbit red cells .
    Maximin 78
  • HY-161380
    Antifungal agent 96

    		Fungal Infection
    Antifungal agent 96 (Compound WZ-2) is an antifungal agent with good blood-brain barrier permeability and brain penetration. Antifungal agent 96 inhibits the growth of C. neoformans H99 and C. albicans 0304103 with MIC values of 0.016 and 32 μg/mL, respectively .
    Antifungal agent 96
  • HY-P5684
    Maximin H39

    		Bacterial Infection
    Maximin H39 is an antimicrobial peptide. MaximinH39 has antibacterial activity against C. albicans, S. aureus, B. subtilis (MIC: 9.4, 9.4, 18.8 μg/mL). Maximin H39 has hemolytic activities against human and rabbit red cells .
    Maximin H39
  • HY-B0999
    Chlorindanol

    Clorindanol; 7-Chloro-4-indanol

    		 Bacterial Infection
    Chlorindanol (7-Chloro-4-indanol) is a topical antiseptic or sanitizer. Chlorindanol is rapidly lethal to vegetative bacteria, Trichophyton sp., C. albicans, E. histolytica cysts and trophozoites, T. vaginalis, and spermatozoa in vitro. Chlorindanol is klow systemic toxicity, well skin/eyes/genital mucosa tolerance and nonallergenic.
    Chlorindanol
  • HY-146024
    Antifungal agent 28

    		Fungal Infection
    Antifungal agent 28 (compound 18) is a potent and selective antifungal agent. Antifungal agent 28 inhibits pathogenic strains of C. albicans and non-albicans species including fluconazole-resistant strains. Antifungal agent 28 inhibits Cryptococcus and Aspergillus strains. Antifungal agent 28 disrupts mature Candida biofilm .
    Antifungal agent 28
  • HY-143335
    Antifungal agent 52

    		Fungal Infection
    Antifungal agent 52 (compound 6c) is a tetrazole derivative. Antifungal agent 52 inhibits the synthesis of Ergosterol (HY-N0181). Antifungal agent 52 exhibit a significant antifungal activity against Candida albicans. Antifungal agent 52 affects C. albicans sessile cell membrane permeabilization .
    Antifungal agent 52
  • HY-W016288
    Naphthalene-2,3-Dicarboxaldehyde

    2,3-Naphthalenedicarboxaldehyde; Naphthalene-2,3-dialdehyde

    		 Fungal Infection
    Naphthalene-2,3-Dicarboxaldehyde (2,3-Naphthalenedicarboxaldehyde), a phthaldehyde derivative, is a fungal ASADH inhibitor (Ki: 45 渭M). Naphthalene-2,3-Dicarboxaldehyde inhibits the growth of C. albicans CAF2-1 with IC50 of 58.2 渭M and MIC of 12 渭g/mL .
    Naphthalene-2,3-Dicarboxaldehyde
  • HY-P5688
    Maximin 68

    		Bacterial Infection
    Maximin 68 is an antimicrobial peptide. Maximin 68 has antibacterial activity against C. albicans, S. aureus, E. coli, B. subtilis (MIC: 18.8, 9.4, 37.5, 9.4 μg/mL). Maximin 68 has hemolytic activities against human and rabbit red cells .
    Maximin 68
  • HY-15660
    Efinaconazole
    1 Publications Verification

    KP-103

    		 Fungal Infection
    Efinaconazole (KP-103) is a triazole antifungal agent and againsts T. mentagrophytes SM-110 and C. albicans ATCC 10231 with MICs of 0.0039 μg/mL and 0.00098 μg/mL, respectively . Efinaconazole has a potent in vitro activity against fungal pathogens including dermatophytes, Candida and Malassezia species .
    Efinaconazole
  • HY-151410
    Chitin synthase inhibitor 5

    		Fungal Infection
    Chitin synthase inhibitor 5 (compound 9a) is an inhibitor of chitin synthase with an IC50 value of 0.14 mM. Chitin synthase inhibitor 5 shows broad-spectrum antifungal activity in vitro and shows good inhibition to C. albicans, A. flavus, A. fumigatus and C. neoformans. Chitin synthase inhibitor 5 can be used for the research of fungal .
    Chitin synthase inhibitor 5
  • HY-N10611
    Elsinochrome A

    		Reactive Oxygen Species Apoptosis Autophagy Fungal Fluorescent Dye Infection Cancer
    Elsinochrome A is a perylene quinone photosensitizer, and can generate reactive oxygen species (ROS) to induce apoptosis and autophagy under light excitation. Elsinochrome A also shows antifungal activity against C. albicans biofilm through photodynamic antimicrobial chemotherapy (PACT). Elsinochrome A can be used for research of photodynamic therapy (PDT) (Ex: 460 nm) .
    Elsinochrome A
  • HY-B0101S
    Fluconazole-d4

    UK-49858-d4

    		 Fungal Antibiotic Infection
    Fluconazole-d4 is the deuterium labeled Fluconazole. Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candida albicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL[1].
    Fluconazole-d4
  • HY-147919
    Antifungal agent 33

    		Fungal Infection
    Antifungal agent 33 (compound 4e) is a potent antifungal agent. Antifungal agent 33 exhibits remarkable antifungal activity against C. albicans, with a MIC of 16 μg/mL. Antifungal agent 33 shows potent inhibitory activity against Lanosterol 14α-demethylase (CYP51), with an IC50 of 0.19 μg/mL .
    Antifungal agent 33
  • HY-156252
    Antifungal agent 75

    		Fungal Infection
    Antifungal agent 75 (compound 6r) is a potent antifungal agent against Candida albicans. Antifungal agent 75 significantly inhibits the formation of C. albicans biofilm, increases the permeability of the cell membrane, reduces the ergosterol level of the cell membrane, damages the membrane structure, and destroys the integrity of the cell structure to exert excellent antifungal activity .
    Antifungal agent 75
  • HY-146196
    Anticandidal agent-1

    		Bacterial Infection
    Anticandidal agent-1 (compound c2) is a potent and broad-spectrum anticandidal agent. Anticandidal agent-1 shows anticandidal activity against C. albicans and C. glabrata, with MIC50 values of 8.65 and 13.51 μg/mL, respectively. Anticandidal agent-1 inhibits biofilm by blocking hyphal elongation and filamentation .
    Anticandidal agent-1
  • HY-15660S
    Efinaconazole-d4

    KP-103-d4

    		 Isotope-Labeled Compounds Fungal Infection
    Efinaconazole-d4 is the deuterium labeled Efinaconazole. Efinaconazole (KP-103) is a triazole antifungal agent and againsts T. mentagrophytes SM-110 and C. albicans ATCC 10231 with MICs of 0.0039 μg/mL and 0.00098 μg/mL, respectively[1]. Efinaconazole has a potent in vitro activity against fungal pathogens including dermatophytes, Candida and Malassezia species[1].
    Efinaconazole-d4
  • HY-N7307
    Pachybasin

    		Bacterial Infection
    Pachybasin is a major metabolite from culture broth of endophytic coelomyceteous AFKR-18 fungus. Pachybasin showes antimicrobial activities against E. coli, B. subtilis, M. luteus, S. cerevisiae, C. albicans, A. niger, and A. flavus, with MIC values of 64.0 μg/mL, and against S. aureus and F. oxysporum with MIC values of 32.0 and 16.0 μg/mL respectively .
    Pachybasin
  • HY-115959
    Anticancer agent 34

    		Bacterial Inflammation/Immunology Cancer
    Anticancer agent 34 (compound 9), a sulfonylurea derivative, is a potent antimicrobial and anticancer agent. Anticancer agent 34 inhibits the microbial growth of B. mycoides, E. coli, and C. albicans with a MIC between 0.156 and 0.039 mg/ml. Anticancer agent 34 inhibits A549, PC3 cell growth with IC50s of 8.4 µg/ml, 7.8 µg/ml, respectively .
    Anticancer agent 34
  • HY-115961
    Anticancer agent 36

    		Bacterial Inflammation/Immunology Cancer
    Anticancer agent 36 (compound 11), a sulfonylurea derivative, is a potent antimicrobial and anticancer agent. Anticancer agent 36 inhibits the microbial growth of B. mycoides, E. coli, and C. albicans with a MIC between 0.156 and 0.039 mg/L. Anticancer agent 36 inhibits A549, PC3 cell growth with IC50s of 19.7 µg/mL, 11.9 µg/mL, respectively .
    Anticancer agent 36
  • HY-P5681
    Human α-Defensin 6

    		Bacterial Infection Inflammation/Immunology
    Human α-Defensin 6, a 32-residue cysteine-rich peptide, can inhibit bacterial invasion and contribute to the mucosal immunity. Human α-Defensin 6 forms ordered self-assembly fibrils and nanonets that surround and entangle bacteria after stochastic binding to bacterial surface proteins. Human α-Defensin 6 also inhibits C. albicans biofilm formation .
    Human α-Defensin 6
  • HY-151422
    Chitin synthase inhibitor 12

    		Fungal Infection Cancer
    Chitin synthase inhibitor 12 is a chitin synthase inhibitor. Chitin synthase inhibitor 12 shows excellent inhibitory activity with an IC50 value of 0.16 mM. Chitin synthase inhibitor 12 also is a broad-spectrum antifungal agent and has significantly antifungal activity against drug-resistant fungal variants, such as C. albicans and C. neoformans. Chitin synthase inhibitor 12 can be used for the research of invasive fungal infections (IFIs) .
    Chitin synthase inhibitor 12
  • HY-151420
    Chitin synthase inhibitor 10

    		Fungal Infection Cancer
    Chitin synthase inhibitor 10 is a chitin synthase inhibitor. Chitin synthase inhibitor 10 shows excellent chitin synthase inhibitory activity with an IC50 value of 0.11 mM. Chitin synthase inhibitor 10 also is an antifungal agent and has significantly antifungal activity against drug-resistant fungal variants, such as C. albicans and C. neoformans. Chitin synthase inhibitor 10 can be used for the research of invasive fungal infections (IFIs) .
    Chitin synthase inhibitor 10
  • HY-155545
    Antifungal agent 60

    		Fungal Infection
    Antifungal agent 60 (compound 16) is an inhibitor of ergosterol biosynthesis with broad-spectrum antifungal activity. Antifungal agent 60 inhibits 7 human pathogenic fungal species, 2 fluconazole-resistant C. albicans isolates and 2 multi-drug resistant Candida auris isolates. Antifungal agent 60 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Antifungal agent 60
  • HY-131044
    5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione

    		Bacterial Fungal Infection
    5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione (Compound 4) has antimicrobial, anti-diabetic and antioxidant activities. 5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione inhibits B. subtilis, S. aureus, K. pneumonia, E. coli, and S. typhi with MICs of 4.5-9.9 μΜ/mL, and inhibits A. niger and C. albicans with MICs of 4.99 μΜ/mL .
    5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione
  • HY-144694
    HDAC/HSP90-IN-3

    		HSP HDAC Fungal Infection
    HDAC/HSP90-IN-3 (compound J5) is a potent and selective fungal Hsp90 and HDAC dual inhibitor, with IC50 values of 0.83 and 0.91 μM, respectively. HDAC/HSP90-IN-3 shows antifungal activity against azole resistant C. albicans. HDAC/HSP90-IN-3 can suppress important virulence factors and down-regulate drug-resistant genes ERG11 and CDR1 .
    HDAC/HSP90-IN-3
  • HY-162273
    Antibacterial agent 189

    		Bacterial Smo Gli Infection Cancer
    Antibacterial agent 189 (compound 3a) is a potent antimicrobial agent. Antibacterial agent 189 offers high binding energy against the target OMPA/exo-1,3-beta-glucanase proteins. Antibacterial agent 189 exhibits the potent antimicrobial activities against E. coli, P. aeruginosa, S. aureus, B. subtilis, C. Albicans and A. flavus. Antibacterial agent 189 shows high binding energy against target SMO and SUFU/GLI-1 proteins .
    Antibacterial agent 189

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