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Results for "

C5aR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Complement System (11) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Inflammation/Immunology (11)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-147585

C5aR-IN-1	Complement System	Inflammation/Immunology
C5aR-IN-1 is a potent inhibitor of *C5aR*. Increased level of C5a has been associated with disorders such as autoimmune disorders and inflammatory disorders. C5aR-IN-1 has the potential for the research of inflammation diseases (extracted from patent WO2022028586A1, compound 47) .

HY-147586

C5aR-IN-2	Complement System	Inflammation/Immunology
C5aR-IN-2 is a potent inhibitor of *C5aR*. Increased level of C5a has been associated with disorders such as autoimmune disorders and inflammatory disorders. C5aR-IN-2 has the potential for the research of inflammation diseases (extracted from patent WO2022028586A1, compound 49) .

HY-147587

C5aR-IN-3	Complement System	Inflammation/Immunology
C5aR-IN-3 is a potent inhibitor of *C5aR*. Increased level of C5a has been associated with disorders such as autoimmune disorders and inflammatory disorders. C5aR-IN-3 has the potential for the research of inflammation diseases (extracted from patent WO2022028586A1, compound 89) .

HY-163378

C5aR1 antagonist 1	Complement System	Inflammation/Immunology
C5aR1 antagonist 1 (Compound 7e) is an orally active C5a receptor 1 (C5aR1) antagonist. C5aR1 antagonist 1 is active in DISCO and migration assays, with IC₅₀ values of 38 nM and 17 nM, respectively. C5aR1 antagonist 1 can be used for the research of acute and chronic inflammatory diseases .

HY-163379

C5aR1 antagonist 2	Complement System	Inflammation/Immunology
C5aR1 antagonist 2 (Compound 6a) is an orally active C5a receptor 1 (C5aR1) antagonist that shows efficacy in inhibiting the C5a-induced neutrophil count increase. C5aR1 antagonist 2 is potent in the DISCO and migration assays, with IC₅₀ values of 21 and 3 nM, respectively. C5aR1 antagonist 2 can be used for the research of acute and chronic inflammatory diseases .

HY-RS01750

C5AR1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
C5AR1 Human Pre-designed siRNA Set A contains three designed siRNAs for C5AR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

C5AR1 Human Pre-designed siRNA Set A C5AR1 Human Pre-designed siRNA Set A

HY-RS01751

C5AR2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
C5AR2 Human Pre-designed siRNA Set A contains three designed siRNAs for C5AR2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

C5AR2 Human Pre-designed siRNA Set A C5AR2 Human Pre-designed siRNA Set A

HY-110136A

PMX 205 Trifluoroacetate 5 Publications Verification	Complement System	Inflammation/Immunology
PMX 205 Trifluoroacetate is a potent complement C5a receptor (C5aR; CD88) antagonist.

HY-110136

PMX 205

Complement System Inflammation/Immunology

PMX 205 is a potent complement C5a receptor (C5aR; CD88) antagonist.
HY-17627

Avacopan

1 Publications Verification

CCX168

Avacopan (CCX168) is a potent, selective and orally available complement 5a receptor (C5aR) inhibitor with an IC₅₀ of 0.1 nM.

PMX 205	Complement System	Inflammation/Immunology
PMX 205 is a potent complement C5a receptor (C5aR; CD88) antagonist.

Avacopan 1 Publications Verification CCX168
Avacopan (CCX168) is a potent, selective and orally available complement 5a receptor (C5aR) inhibitor with an IC₅₀ of 0.1 nM.

HY-110060

NDT 9513727	Complement System	Inflammation/Immunology
NDT 9513727 is a potent, selective, orally active and competitive inverse agonist of the human C5aR (C5a receptor), with an IC₅₀ of 11.6 nM. NDT 9513727 can be used for the research of human inflammatory diseases .

HY-106178

PMX-53 3 Publications Verification 3D53	Complement System	Cardiovascular Disease Inflammation/Immunology Cancer
PMX-53 (3D53) is a synthetic peptidic and a potent and orally active complement C5a receptor (CD88) antagonist with an IC₅₀ of 20 nM. PMX-53 is also a low-affinity MrgX2 agonist that stimulates MrgX2-mediated mast cell degranulation. PMX-53 specifically binds to *C5aR1* and does not bind to the second C5aR (C5L2) and C3aR. PMX-53 has anti-inflammatory, anticancer and antiatherosclerotic effects ^[5] .

HY-P99450

Avdoralimab IPH 5401; Anti-C5aR1 mAb	Complement System	Inflammation/Immunology Cancer
Avdoralimab (IPH 5401) is a fully human IgGκ monoclonal antibody that targets the complement C5a receptor 1 (C5aR1) that prevents its binding to C5a. Avdoralimab can be used for complement-driven inflammatory diseases and solid tumours research .

HY-148141

JPE-1375	Complement System	Inflammation/Immunology
JPE-1375 is a complement C5a receptor 1 (C5aR1) antagonist. JPE-1375 effectively inhibits polymorphonuclear leukocyte mobilization (EC₅₀=6.9 µM) and reduces TNF levels (EC₅₀=4.5 µM) in mice. JPE-1375 can be used in studies of autoimmune and inflammatory diseases .

Cat. No.	Product Name	Target	Research Area

HY-106178

PMX-53 3 Publications Verification 3D53	Complement System	Cardiovascular Disease Inflammation/Immunology Cancer
PMX-53 (3D53) is a synthetic peptidic and a potent and orally active complement C5a receptor (CD88) antagonist with an IC₅₀ of 20 nM. PMX-53 is also a low-affinity MrgX2 agonist that stimulates MrgX2-mediated mast cell degranulation. PMX-53 specifically binds to *C5aR1* and does not bind to the second C5aR (C5L2) and C3aR. PMX-53 has anti-inflammatory, anticancer and antiatherosclerotic effects ^[5] .

HY-145237

BM213

Peptides Cancer

BM213, a potent and selective agonist for C5aR1, shows antitumor activity in a mouse model of mammary carcinoma.

BM213	Peptides	Cancer
BM213, a potent and selective agonist for *C5aR1*, shows antitumor activity in a mouse model of mammary carcinoma.

HY-P5509

C5aR1 antagonist peptide	Peptides	Others
C5aR1 antagonist peptide is a biological active peptide. (This linear peptide is derived from the C-terminus of the chemokine, complement fragment 5 anaphylatoxin (C5a). This peptide functions to inhibit C5a binding and function at human and rat C5a receptors. C5a is crucial to triggering cellular immune responses and its overexpression is involved in arthritis, Alzheimer’s disease, cystic fibrosis, systemic lupus erythematosus, and other immunoinflammatory diseases.)

Cat. No.	Product Name	Target	Research Area

HY-P99450

Avdoralimab IPH 5401; Anti-C5aR1 mAb	Complement System	Inflammation/Immunology Cancer
Avdoralimab (IPH 5401) is a fully human IgGκ monoclonal antibody that targets the complement C5a receptor 1 (C5aR1) that prevents its binding to C5a. Avdoralimab can be used for complement-driven inflammatory diseases and solid tumours research .

Species:	Human (2)
Tag:	His (2)
Source:	HEK293 (1) E. coli Cell-free (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P700398

	C5AR1 Protein-VLP, Human (HEK293, His) complement component 5a receptor 1; C5R1, complement component 5 receptor 1 (C5a ligand); C5a anaphylatoxin chemotactic receptor; C5A; C5aR; CD88; C5a-R; C5a ligand; C5a anaphylatoxin receptor; complement component 5 receptor 1; C5R1	Human	HEK293
	C5AR1 Protein-VLP, Human (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays.

HY-P702227

	C5AR2 Protein, Human (Cell-Free, His) C5a anaphylatoxin chemotactic receptor 2; Complement component 5a receptor 2; G-protein coupled receptor 77	Human	E. coli Cell-free
	The C5AR2 protein is a receptor for C3a, C4a, and C5a peptides as well as ASP/C3adesArg, C4adesArg, and C5adesArg, and is weakly coupled to G(i)-mediated signaling pathways. It interacts with C3 and exhibits higher affinity for the lipogenic hormone ASP. C5AR2 Protein, Human (Cell-Free, His) is the recombinant human-derived C5AR2 protein, expressed by E. coli Cell-free , with C-10*His labeled tag. The total length of C5AR2 Protein, Human (Cell-Free, His) is 337 a.a., with molecular weight of 38.9 kDa.


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