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CALY+Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Carbonic Anhydrase (13) CDK (1) Dipeptidyl Peptidase (1) HIV (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (1) Endocrinology (1) Infection (2) Metabolic Disease (2) Neurological Disease (2)

14

Inhibitors & Agonists

1

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas

*CA inhibitor* 1** GS-6207 analog	HIV	Infection
CA inhibitor 1 (GS-6207 analog) is a potent HIV capsid inhibitor for HIV inhibition. CA inhibitor 1 is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B0782S

Acetazolamide-d3

Carbonic Anhydrase Cardiovascular Disease

Acetazolamide-d₃ is deuterium labeled Acetazolamide, which is a potent carbonic anhydrase (CA) inhibitor.
HY-152140

hCAII-IN-8

Carbonic Anhydrase Cancer

hCAII-IN-8, an amide, is a highly selective carbonic anhydrase (CA) inhibitor with an IC₅₀ value of 0.18 μM against hCA II.
HY-119919

Clofenamide

Aquedux
Carbonic Anhydrase Metabolic Disease

Clofenamide (Aquedux) is a carbonic anhydrase (CA) inhibitor. Clofenamide exhibits diuretic activity.
HY-156013

CA inhibitor 2

Carbonic Anhydrase Cancer Endocrinology

CA inhibitor 2 (Compound 4H) is a carbonic anhydrase inhibitor (IC₅₀: 0.033 μM).

*Carbonic anhydrase inhibitor* 9**	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 9 is a potent carbonic anhydrase (CA) inhibitor with K_is of 56.4 and 56.9 nM for hCA II and IX, respectively. Antiproliferative activity.

*Carbonic anhydrase inhibitor* 13**	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 13 (compound 7) is a potent carbonic anhydrase (CA) inhibitor, which features 3-methylthiazolo[3,2-a]benzimidazole moiety (as a tail) connected to the zinc anchoring benzenesulfonamide moiety via ureido linker.

U-104 3 Publications Verification SLC-0111	Carbonic Anhydrase	Cancer
U-104 (SLC-0111) is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with K_i values of 45.1 nM and 4.5 nM, respectively. U-104 shows a significant delay in tumor growth in mice model.

Benzolamide CL11366	Carbonic Anhydrase	Neurological Disease
Benzolamide (CL11366) is a potent carbonic anhydrase (CA) inhibitor, with K_is of 15 nM, 9 nM, 94 nM and 78 nM for hCA I, hCA II, EcoCAγ and VchCAγ, respectively. Benzolamide also inhibits CAS3, with a K_i of 54 nM. Benzolamide can be used for the research of glaucoma and seizures.

hCAIX/XII-IN-6	Carbonic Anhydrase	Infection
hCAIX/XII-IN-6 is an orally active carbonic anhydrase (CA) inhibitor. hCAIX/XII-IN-6 inhibits human CA isoforms hCA I, II, IV, IX, and XII with K_i values of 6697 nM, 2950 nM, 4093 nM, 4.1 nM and 7.7 nM, respectively. hCAIX/XII-IN-6 can be used for the research of rheumatoid arthritis (RA).

hCAIX/XII-IN-5	Carbonic Anhydrase Apoptosis	Cancer
hCAIX/XII-IN-5 (Coumarin 9a) a carbonic anhydrase (CA) inhibitor, and exhibits excellent hCA IX/XII selectivity (K_i=93.9 and 85.7 nM, respectively) over hCA I and hCA II. hCAIX/XII-IN-5 shows anti-proliferative activities to cancer cells. hCAIX/XII-IN-5 can delay cell cycle and induce apoptosis.

*Carbonic anhydrase inhibitor* 14**	Carbonic Anhydrase CDK	Cancer
Carbonic anhydrase inhibitor 14 (Compound 8b) is a carbonic anhydrase (CA) inhibitor with K_i values of 1203, 99.7, 9.4 and 27.7 nM against hCA I, hCA II, hCA IX and hCA XII, respectively. Carbonic anhydrase inhibitor 14 can also inhibit CDK2 with an IC₅₀ of 20.3 μM. Carbonic anhydrase inhibitor 14 shows antitumor activity.

DPP IV/hCA II-IN-1	Dipeptidyl Peptidase Carbonic Anhydrase	Metabolic Disease
DPP IV/hCA II-IN-1 is a potent and selective dipeptidyl peptidase IV (DPP IV) and carbonic anhydrase (CA) inhibitor with an IC₅₀ value of 0.049 μM for DPP IV and with K_i values of 0.0361, 0.0428, 0.0941, 0.1328, 0.2615, and 3.034 μM for CA II, CA VB, CA VA, CA IX, CA I, and CA IV, respectively.

hCAI/II-IN-6	Carbonic Anhydrase	Neurological Disease
hCAI/II-IN-6 is an orally active human carbonic anhydrase (CA) inhibitor. hCAI/II-IN-6 selectively inhibits hCA II and hCA VII isoforms with K_i values of 220, 4.9, 6.5 and ＞50000 nM for hCA I, hCA II , hCA VII and hCA XII respectively. hCAI/II-IN-6 shows anticonvulsant activity and anti maximal electroshock (MES) activity in vivo. hCAI/II-IN-6 can be used for the research of epilepsy.

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