CAMKII

By Targets:	Apoptosis (1) Aurora Kinase (1) Autophagy (9) CaMK (21) CRFR (1) Fungal (1) iGluR (1) P2X Receptor (1) Phosphatase (1) PKC (1) PROTACs (1) ROCK (1)
By Research Areas:	Cancer (6) Endocrinology (1) Infection (1) Inflammation/Immunology (1) Metabolic Disease (2) Neurological Disease (15)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-18271

CaMKII-IN-1 2 Publications Verification	CaMK Autophagy	Inflammation/Immunology
CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor with IC50 of 63 nM; significantly high selectivity against CaMKIV, MLCK, p38a, Akt1, and PKC.

HY-146268

CaMKIIα-IN-1	CaMK	Neurological Disease
CaMKIIα-IN-1 (Compound 4d) is an orally active *Ca ²⁺/calmodulin-dependent protein kinase II α (CaMKIIα)* inhibitor with a K_D of 219 nM for CaMKIIα WT hub. CaMKIIα-IN-1 has good metabolic stability .

HY-P10071

CaMKII inhibitory peptide KIIN

Calmodulin Kinase IINtide; CaM-KIIN; CaM-KIINβ
CaMK Others

CaMKII inhibitory peptide KIIN is a potent inhibitor of CaMKII .

CaMKII inhibitory peptide KIIN Calmodulin Kinase IINtide; CaM-KIIN; CaM-KIINβ	CaMK	Others
CaMKII inhibitory peptide KIIN is a potent inhibitor of *CaMKII* .

HY-156104

CaMKIIα-PHOTAC	PROTACs CaMK	Neurological Disease
CaMKIIα-PHOTAC is a photochemically targeted chimera (PHOTAC) targeting Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα). Molecules such as PHOTAC can catalyze the ubiquitination and degradation of target proteins through the endogenous proteasome under specific wavelengths of light. CaMKIIα-PHOTAC reduces synaptic function under light conditions, and it attenuates the intensity of evoked field excitatory postsynaptic potentials in the mouse hippocampus in response to physiological stimuli. CaMKIIα-PHOTAC plays a critical role in maintaining long-term potentiation and memory capacity in subcellular dendritic domains .

HY-P5987

Calmodulin Kinase IINtide, Myristoylated Myr-CAMKIINtide	CaMK	Neurological Disease
Calmodulin Kinase IINtide, Myristoylated (Myr-CaMKIINtide) is a selective and noncompetitive inhibitor of *CaMKII* .

HY-P3811

Autocamtide-3

CaMK Neurological Disease

Autocamtide-3, a 13-amino-acid peptide containing Thr287, is a selective CaMKII (Ca ²⁺/calmodulin-dependent kinase II) (CaMK) substrate .

Autocamtide-3	CaMK	Neurological Disease
Autocamtide-3, a 13-amino-acid peptide containing Thr287, is a selective CaMKII (Ca ²⁺/calmodulin-dependent kinase II) (CaMK) substrate .

HY-P3811A

Autocamtide-3 acetate	CaMK	Neurological Disease
Autocamtide-3 acetate, a 13-amino-acid peptide containing Thr287, is a selective CaMKII (Ca ²⁺/calmodulin-dependent kinase II) (CaMK) substrate .

HY-15720B

Glycyl H-1152 hydrochloride	ROCK Aurora Kinase CaMK	Neurological Disease
Glycyl H-1152 hydrochloride (compound 18) is a glycyl derivative of Rho-kinase inhibitors H-1152 dihydrochloride. Glycyl H-1152 hydrochloride inhibits ROCKII, Aurora A, *CAMKII* and PKG, with IC₅₀s of 0.0118, 2.35, 2.57 and 3.26 μM respectively. Glycyl H-1152 hydrochloride has higher selective than H-1152 hydrochloride .

HY-100779

Rimacalib

SMP 114

Rimacalib (SMP 114) is a Ca ²⁺/calmodulin-dependent protein kinase II (CaMKII) inhibitor, with IC₅₀s of ~1 μM for CaMKIIα to ~30 μM for CaMKIIγ .

Rimacalib SMP 114
Rimacalib (SMP 114) is a Ca ²⁺/calmodulin-dependent protein kinase II (CaMKII) inhibitor, with IC₅₀s of ~1 μM for CaMKIIα to ~30 μM for CaMKIIγ .

HY-P0225

Autocamtide 2 Autocamtide II	CaMK Autophagy	Neurological Disease
Autocamtide 2 is a highly selective peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). It can be used in the CaMKII activity assay.

HY-151797

Ph-HTBA	CaMK	Neurological Disease
Ph-HTBA is a high-affinity, brain-penetrating modulator for CaMKIIα. Ph-HTBA has binding affinity for CaMKIIα with a K_d value of 757 nM. Ph-HTBA can be used for the research of ischemia and neurodegenerative disorders .

HY-13290

KN-62 5+ Cited Publications	CaMK P2X Receptor	Metabolic Disease Cancer
KN-62 is a selective and reversible inhibitor of calmodulin-dependent protein kinase II (CaMK-II) with a K_i of 0.9 μM for rat brain CaMK-II. KN-62 directly binds to the calmodulin binding site of CaMK-II. KN-62 displays noncompetitive antagonism at P2X₇ receptors in HEK293 cells, with an IC₅₀ value of approximately 15 nM.

HY-15465B

KN-93 phosphate Maximum Cited Publications 54 Publications Verification	CaMK Autophagy	Cancer
KN-93 phosphate is a novel membrane-permeant synthetic inhibitor of purified neuronal *CaMK-II*, with K_i of 370 nM.

HY-P0214

Autocamtide-2-related inhibitory peptide	CaMK Autophagy	Neurological Disease
Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of *CaMKII* with an IC₅₀ of 40 nM.

HY-15465

KN-93 Maximum Cited Publications 54 Publications Verification	CaMK Autophagy	Cancer
KN-93 is a cell-permeable, reversible and competitive inhibitor calmodulin-dependent kinase type II (CaMKII) with a K_i of 370 nM.

HY-15465A

KN-93 hydrochloride Maximum Cited Publications 54 Publications Verification	CaMK Autophagy	Cancer
KN-93 hydrochloride is a cell-permeable, reversible and competitive inhibitor calmodulin-dependent kinase type II (CaMKII) with a K_i of 370 nM.

HY-P0214A

Autocamtide-2-related inhibitory peptide TFA 1 Publications Verification	CaMK Autophagy	Neurological Disease
Autocamtide-2-related inhibitory peptide (TFA) is a highly specific and potent inhibitor of *CaMKII* with an IC₅₀ of 40 nM.

HY-103382

Arcyriaflavin A	Fungal	Infection
Arcyriaflavin A is a fungal metabolite obtained from the fungi, Nocardiopsis. Arcyriaflavin A is an inhibitor of CDK4 (IC₅₀ = 140 nM) and CaMKII (IC₅₀ = 25 nM) .

HY-P5525

AC3-I, myristoylated Autocamtide-3 Derived Inhibitory Peptide	CaMK	Others
AC3-I, myristoylated is a biological active peptide. (This is a myristoylated form of Autocamtide-3-Derived Inhibitory Peptide (AC3-I), a highly specific inhibitor of Calmodulin-Dependent Protein Kinase ll (CaMKII) that is resistant to proteolysis. AC3-I is derived from Autocamtide-3, a substrate for CaMKII, with the Thr-9 phosphorylation site substituted with Ala.)

HY-P0271

Syntide 2	CaMK Autophagy	Neurological Disease
Syntide 2, a Ca ²⁺- and calmodulin (CaM)-dependent protein kinase II (CaMKII) substrate peptide, selectively inhibits the gibberellin (GA) response, leaving constitutive and abscisic acid-regulated events unaffected .

HY-P0271A

Syntide 2 TFA 1 Publications Verification	CaMK	Neurological Disease
Syntide 2 (TFA), a Ca ²⁺- and calmodulin (CaM)-dependent protein kinase II (CaMKII) substrate peptide, selectively inhibits the gibberellin (GA) response, leaving constitutive and abscisic acid-regulated events unaffected .

HY-P0215

Autocamtide-2-related inhibitory peptide, myristoylated
Autocamtide-2-related inhibitory peptide, myristoylated is the myristoylated Autocamtide-2-related inhibitory peptide. Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of *CaMKII* with an IC₅₀ of 40 nM .

HY-P0215A

Autocamtide-2-related inhibitory peptide, myristoylated TFA	CaMK Autophagy	Neurological Disease
Autocamtide-2-related inhibitory peptide, myristoylated TFA is the myristoylated Autocamtide-2-related inhibitory peptide. Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of *CaMKII* with an IC₅₀ of 40 nM .

HY-15517

KN-92	Others	Cancer
KN-92 is an inactive derivative of KN-93, without CaM kinase inhibitory activity. KN-92 is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 is a cell-permeable, reversible and competitive CaMKII inhibitor .

HY-15517A

KN-92 phosphate 5 Publications Verification	Others	Cancer
KN-92 phosphate is an inactive derivative of KN-93, without CaM kinase inhibitory activity. KN-92 phosphate is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 is a cell-permeable, reversible and competitive CaMKII inhibitor .

HY-135741

NYX-2925	iGluR	Neurological Disease
NYX-2925 is an orally active NMDAR modulator. NYX-2925 restores levels of activated Src and Src phosphorylation sites on GluN2A and GluN2B in the mPFC. NYX-2925 shows no effect on CAMKII, and any addictive or sedative/ataxic side effects. NYX-2925 can be used for research of a variety of NMDA receptor-mediated central nervous system disorders .

HY-108599

DCP-LA 2 Publications Verification FR236924	PKC CaMK Phosphatase Apoptosis	Neurological Disease
DCP-LA (FR236924), a linoleic acid derivative, selectively and directly activates PKCε. DCP-LA activates Ca( ²⁺)/calmodulin-dependent protein kinase II (CaMKII) and inhibits protein phosphatase-1 (PP-1) to stimulate AMPA receptor exocytosis. DCP-LA inhibits activation of caspase-3/-9 and protects neurons at least in part from oxidative stress-induced apoptosis .

HY-P2847

Urocortin II, mouse	CRFR	Metabolic Disease Endocrinology
Urocortin II, mouse is a potent and selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor with K_i values of 0.66 nM and ﹥100 nM for CRFR2 and CRFR1, respectively. Urocortin II, mouse activates CRF2 receptors in a cAMP/PKA- and Ca ²⁺/CaMKII-dependent manner.Urocortin II, mouse is expressed in discrete areas of the central nervous system, and activates central neurons involved in the processing of visceral sensory information, and in modulating autonomic outflow .

Cat. No.	Product Name	Target	Research Area

HY-P3811A

Autocamtide-3 acetate	CaMK	Neurological Disease
Autocamtide-3 acetate, a 13-amino-acid peptide containing Thr287, is a selective CaMKII (Ca ²⁺/calmodulin-dependent kinase II) (CaMK) substrate .

HY-P0225

Autocamtide 2 Autocamtide II	CaMK Autophagy	Neurological Disease
Autocamtide 2 is a highly selective peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). It can be used in the CaMKII activity assay.

HY-P10071

CaMKII inhibitory peptide KIIN

Calmodulin Kinase IINtide; CaM-KIIN; CaM-KIINβ
CaMK Others

CaMKII inhibitory peptide KIIN is a potent inhibitor of CaMKII .

CaMKII inhibitory peptide KIIN Calmodulin Kinase IINtide; CaM-KIIN; CaM-KIINβ	CaMK	Others
CaMKII inhibitory peptide KIIN is a potent inhibitor of *CaMKII* .

HY-P5987

Calmodulin Kinase IINtide, Myristoylated Myr-CAMKIINtide	CaMK	Neurological Disease
Calmodulin Kinase IINtide, Myristoylated (Myr-CaMKIINtide) is a selective and noncompetitive inhibitor of *CaMKII* .

HY-P3811

Autocamtide-3

CaMK Neurological Disease

Autocamtide-3, a 13-amino-acid peptide containing Thr287, is a selective CaMKII (Ca ²⁺/calmodulin-dependent kinase II) (CaMK) substrate .

Autocamtide-3	CaMK	Neurological Disease
Autocamtide-3, a 13-amino-acid peptide containing Thr287, is a selective CaMKII (Ca ²⁺/calmodulin-dependent kinase II) (CaMK) substrate .

HY-P0214

Autocamtide-2-related inhibitory peptide	CaMK Autophagy	Neurological Disease
Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of *CaMKII* with an IC₅₀ of 40 nM.

HY-P0214A

Autocamtide-2-related inhibitory peptide TFA 1 Publications Verification	CaMK Autophagy	Neurological Disease
Autocamtide-2-related inhibitory peptide (TFA) is a highly specific and potent inhibitor of *CaMKII* with an IC₅₀ of 40 nM.

HY-P5525

AC3-I, myristoylated Autocamtide-3 Derived Inhibitory Peptide	CaMK	Others
AC3-I, myristoylated is a biological active peptide. (This is a myristoylated form of Autocamtide-3-Derived Inhibitory Peptide (AC3-I), a highly specific inhibitor of Calmodulin-Dependent Protein Kinase ll (CaMKII) that is resistant to proteolysis. AC3-I is derived from Autocamtide-3, a substrate for CaMKII, with the Thr-9 phosphorylation site substituted with Ala.)

HY-P0271

Syntide 2	CaMK Autophagy	Neurological Disease
Syntide 2, a Ca ²⁺- and calmodulin (CaM)-dependent protein kinase II (CaMKII) substrate peptide, selectively inhibits the gibberellin (GA) response, leaving constitutive and abscisic acid-regulated events unaffected .

HY-P0271A

Syntide 2 TFA 1 Publications Verification	CaMK	Neurological Disease
Syntide 2 (TFA), a Ca ²⁺- and calmodulin (CaM)-dependent protein kinase II (CaMKII) substrate peptide, selectively inhibits the gibberellin (GA) response, leaving constitutive and abscisic acid-regulated events unaffected .

HY-P5427

EAC3I	Peptides	Others
EAC3I is a biological active peptide. (The autocamtide-3 derived inhibitory peptide (EAC3I) sequence (KKALHRQEAVDAL) mimics the autoinhibitory region of the CaMKII regulatory domain (residues 278–290) and acts by competitively binding to the catalytic site.)

HY-P0215A

Autocamtide-2-related inhibitory peptide, myristoylated TFA	CaMK Autophagy	Neurological Disease
Autocamtide-2-related inhibitory peptide, myristoylated TFA is the myristoylated Autocamtide-2-related inhibitory peptide. Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of *CaMKII* with an IC₅₀ of 40 nM .

HY-P2847

Urocortin II, mouse	CRFR	Metabolic Disease Endocrinology
Urocortin II, mouse is a potent and selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor with K_i values of 0.66 nM and ﹥100 nM for CRFR2 and CRFR1, respectively. Urocortin II, mouse activates CRF2 receptors in a cAMP/PKA- and Ca ²⁺/CaMKII-dependent manner.Urocortin II, mouse is expressed in discrete areas of the central nervous system, and activates central neurons involved in the processing of visceral sensory information, and in modulating autonomic outflow .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-103382

Arcyriaflavin A	Infection Alkaloids Structural Classification Microorganisms Classification of Application Fields Source classification Disease Research Fields Indole Alkaloids	Fungal
Arcyriaflavin A is a fungal metabolite obtained from the fungi, Nocardiopsis. Arcyriaflavin A is an inhibitor of CDK4 (IC₅₀ = 140 nM) and CaMKII (IC₅₀ = 25 nM) .

Species:	Human (4)
Tag:	His (1) GST (4)
Source:	Sf9 insect cells (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P76761

	CaMKII alpha/CAMK2A Protein, Human (sf9, GST) Calcium/calmodulin-dependent protein kinase type II subunit alpha; CAMKA	Human	Sf9 insect cells
	CaMKII α/CAMK2A protein functions autonomously upon Ca(2+)/calmodulin binding and autophosphorylation. CaMKII alpha/CAMK2A Protein, Human (sf9, GST) is the recombinant human-derived CaMKII alpha/CAMK2A protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of CaMKII alpha/CAMK2A Protein, Human (sf9, GST) is 478 a.a., with molecular weight of ~80 kDa.

HY-P76762

	CaMKII beta/CAMK2B Protein, Human (sf9, His-GST) Calcium/calmodulin-dependent protein kinase type II subunit beta; CAM2; CAMK2; CAMKB	Human	Sf9 insect cells
	CaMKII beta/CAMK2B, a calcium/calmodulin-dependent protein kinase, autonomously functions after Ca(2+)/calmodulin-binding and autophosphorylation. It plays vital roles in dendritic spine and synapse formation, neuronal plasticity, and the regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, it contributes to actin cytoskeleton reorganization, dendritic arborization, and migration of developing neurons. Additionally, it modulates skeletal muscle function in response to exercise and participates in the JAK-STAT signaling pathway by phosphorylating STAT1. Moreover, it phosphorylates RETREG1, enhancing its reticulophagy activity under endoplasmic reticulum stress conditions. CaMKII beta/CAMK2B Protein, Human (sf9, His-GST) is the recombinant human-derived CaMKII beta/CAMK2B protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of CaMKII beta/CAMK2B Protein, Human (sf9, His-GST) is 503 a.a., with molecular weight of ~85 kDa.

HY-P702655

CaMKII beta/CAMK2B Protein, Human (Q13554-1, sf9, GST)

Calcium/calmodulin-dependent protein kinase type II subunit beta; CAM2; CAMK2; CAMKB
Human Sf9 insect cells

HY-P701720

	CAMK2D Protein, Human (Sf9, GST) CAMK2D; Calcium/calmodulin-dependent protein kinase type II subunit delta; CaM kinase II subunit delta; CaMK-II subunit delta	Human	Sf9 insect cells
	CAMK2D protein regulates calcium levels and excitation-contraction coupling in the heart. CAMK2D Protein, Human (Sf9, GST) is the recombinant human-derived CAMK2D protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of CAMK2D Protein, Human (Sf9, GST) is 498 a.a., .

Cat. No.	Product Name	Application	Reactivity

HY-P80445

CaMKII alpha Antibody 1 Publications Verification Alpha CAMKII; Calcium calmodulin dependent protein kinase II; Calcium/calmodulin dependent protein kinase II alpha B subunit; Calcium/calmodulin dependent protein kinase type II alpha chain; Calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; Calcium/calmodulin-dependent protein kinase II alpha; Calcium/calmodulin-dependent protein kinase II-alpha; Calcium/calmodulin-dependent protein kinase type II subunit alpha; Calcium/calmodulin-dependent protein kinase type IIA; CaM kinase II alpha chain; CaM kinase II alpha subunit; CaM kinase II subunit alpha; CaMK II alpha subunit; CaMK-II subunit alpha; Camk2a; CAMKA; CAMKII; CAMKIINalpha; EC2.7.11.17; KCC2A_HUMAN; KIAA0968; MGC123320; MGC139375; MGC155201; mKIAA0968; PK2CDD; PKCCD; R74975; zgc:112538; zgc:123320;	WB, IP, FC, IHC-P	Human, Mouse, Rat
CaMKII alpha Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 54 kDa, targeting to CaMKII alpha. It can be used for WB,IP,FC,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

HY-P82599

CaMKII beta Antibody (YA2344) CAMK2B; CAM2; CAMK2; CAMKB; Calcium/calmodulin-dependent protein kinase type II subunit beta; CaM kinase II subunit beta; CaMK-II subunit beta; CAMK2G; CAMK; CAMK-II; CAMKG; Calcium/calmodulin-dependent protein kinase type II subunit gamma	WB	Mouse

HY-P82592

CaMKII delta Antibody (YA2337)

CAM kinase 2 delta; CAM kinase II delta; CaM kinase II delta subunit; CaM kinase II subunit delta; CAMK 2d; CaMK-II delta subunit; CAMK2D; CAMKI
WB Human, Rat


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CAMKII

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