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Results for "

CB1+receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Akt (1) Autophagy (14) Cannabinoid Receptor (87) DAGL (2) Dopamine Receptor (1) Drug Isomer (1) Drug Metabolite (1) Endogenous Metabolite (19) Environmental Pollutants (1) GPR55 (2) HIF/HIF Prolyl-Hydroxylase (2) Interleukin Related (2) Isotope-Labeled Compounds (8) mAChR (1) NF-κB (3) NO Synthase (2) Orphan GPCR (1) PERK (1) PPAR (1) Reference Standards (6) TNF Receptor (2) TRP Channel (12)
By Research Areas:	Cancer (3) Cardiovascular Disease (5) Infection (1) Inflammation/Immunology (16) Metabolic Disease (28) Neurological Disease (50)

By Targets:

5-HT Receptor (1)

Akt (1)

Autophagy (14)

Cannabinoid Receptor (87)

DAGL (2)

Dopamine Receptor (1)

Drug Isomer (1)

Drug Metabolite (1)

Endogenous Metabolite (19)

Environmental Pollutants (1)

GPR55 (2)

HIF/HIF Prolyl-Hydroxylase (2)

Interleukin Related (2)

Isotope-Labeled Compounds (8)

mAChR (1)

NF-κB (3)

NO Synthase (2)

Orphan GPCR (1)

PERK (1)

PPAR (1)

Reference Standards (6)

TNF Receptor (2)

TRP Channel (12)

By Research Areas:

Cancer (3)

Cardiovascular Disease (5)

Infection (1)

Inflammation/Immunology (16)

Metabolic Disease (28)

Neurological Disease (50)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15443

AM251 Maximum Cited Publications 23 Publications Verification	Cannabinoid Receptor	Neurological Disease
AM251 is a selective cannabinoid 1 (CB1) receptor antagonist with an IC₅₀ of 8 nM. AM251 also acts as a potent GPR55 agonist with an EC₅₀ of 39 nM ^[1] .

HY-B0151

Pregnenolone Maximum Cited Publications 6 Publications Verification 3β-Hydroxy-5-pregnen-20-one	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the *CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication ^[1] . Pregnenolone is also a TRPM3 channel* activator, and also can weakly activate TRPM1 channels .

HY-B1739

Pregnenolone monosulfate Maximum Cited Publications 6 Publications Verification 3β-Hydroxy-5-pregnen-20-one monosulfate	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the *CB1 receptors. Pregnenolone monosulfate can protect the brain from cannabis intoxication ^[1] . Pregnenolone monosulfate is also a TRPM3 channel* activator, and also can weakly activate TRPM1 channels .

HY-116637

Tetrahydromagnolol Magnolignan	Cannabinoid Receptor GPR55 Drug Metabolite	Infection Neurological Disease Inflammation/Immunology
Tetrahydromagnolol (Magnolignan), the main metabolite of Magnolol, is a potent and selective cannabinoidCB2 receptor agonist (EC₅₀ =170 nM) and GPR55 antagonist. The K_i of Tetrahydromagnolol for CB2 is 416 nM, 20-fold higher than for the CB1 receptor. Magnolol shows antifungal, anti-inflammatory and analgesic effects ^[1] .

HY-B1161A

S-Methoprene 2 Publications Verification (+)-Methoprene; (7S)-Methoprene	Environmental Pollutants Cannabinoid Receptor	Others
S-Methoprene is an insect juvenile hormone analog and effective insecticide that blocks the transition from pupa to adult. S-Methoprene is also a CB(1) receptor ligand and inhibits the binding of the CB1 receptor antagonist [ ³H]CP-55940 to the CB1 receptor (IC₅₀: 19.31 μM) ^[1] .

HY-N0919

Yangonin 1 Publications Verification	Cannabinoid Receptor NF-κB Autophagy	Inflammation/Immunology
Yangonin exhibits affinity for the human recombinant cannabinoid *CB1 receptor* with an IC₅₀ and a K_i of 1.79 μM and 0.72 μM, respectively.

HY-13505

AM281 1 Publications Verification	Cannabinoid Receptor	Neurological Disease
AM281 is a selective *CB1 receptor* antagonist with an IC₅₀ of 9.91 nM. AM281 inhibits CB2 receptor with an IC₅₀ of 13000 nM ^[1].

HY-110189

Pregnenolone monosulfate sodium Maximum Cited Publications 6 Publications Verification 3β-Hydroxy-5-pregnen-20-one monosulfate sodium	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the *CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication ^[1] . Pregnenolone monosulfate sodium is also a TRPM3 channel* activator, and also can weakly activate TRPM1 channels .

HY-117771

DO34 5 Publications Verification	DAGL	Neurological Disease Metabolic Disease
DO34 is a selective DAGL inhibitor, with an IC₅₀ of 6 nM for DAGLα conversion of SAG to 2-AG. DO34 blocks de novo 2-AG synthesis, and suppresses tonic CB₁ receptor activation. DO34 blocks depolarization-induced suppression of excitation and inhibition in the cerebellum and hippocampus. DO34 regulates feeding behavior and locomotor activity in mice. DO34 abolishes AM251-mediated enhancement of parallel fiber-evoked excitatory postsynaptic currents in cerebellar slices from MAGL global knockout mice. DO34 can be used for the research of energy balance disorder and neuroinflammation ^[1] .

HY-13288

Org 27569	Cannabinoid Receptor	Neurological Disease
Org 27569 is a potent *CB1 receptor* allosteric modulator, which increases agonist binding, yet blocks agonist-induced CB1 signaling.

HY-113204

N-Oleoyl glycine 2 Publications Verification	Endogenous Metabolite Cannabinoid Receptor Akt	Metabolic Disease
N-Oleoyl glycine is a lipoamino acid, which stimulates adipogenesis associated with activation of *CB1 receptor* and Akt signaling pathway in 3T3-L1 adipocyte.

HY-10013

Taranabant 2 Publications Verification MK-0364	Cannabinoid Receptor	Metabolic Disease
Taranabant is a highly potent and selective cannabinoid 1 (CB1) receptor inverse agonist that inhibits the binding and functional activity of various agonists, with a binding K_i of 0.13 nM for the human CB1R in vitro.

HY-14791A

(±)-Ibipinabant 1 Publications Verification (±)-SLV319; (±)-BMS-646256	Cannabinoid Receptor	Metabolic Disease
(±)-Ibipinabant ((±)-SLV319) is the racemate of SLV319. (±)-Ibipinabant ((±)-SLV319) is a potent and selective cannabinoid-1 (CB-1) receptor antagonist with an IC₅₀ of 22 nM.

HY-110206

AM6545	Cannabinoid Receptor	Metabolic Disease
AM6545 is a highly selective, brain-free (peripherally active) *CB1 receptor* antagonist (K_i=1.7 nM). AM6545 inhibits endocannabinoid signaling by competitively antagonizing CB1 receptors, inhibiting CB1-mediated appetite stimulation and inflammatory responses without affecting cAMP levels. AM6545 significantly reduces food intake and body weight in mice, while improving metabolic syndrome-related renal impairment (such as proteinuria, fibrosis) and insulin resistance. AM6545 can be used in the study of obesity and its complications ^[1] .

HY-B0151R

Pregnenolone (Standard) 5 Publications Verification 3β-Hydroxy-5-pregnen-20-one (Standard)	Reference Standards Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone (Standard) is the analytical standard of Pregnenolone. This product is intended for research and analytical applications. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the *CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication ^[1] . Pregnenolone is also a TRPM3 channel* activator, and also can weakly activate TRPM1 channels .

HY-14791

Ibipinabant 1 Publications Verification SLV319; BMS-646256	Cannabinoid Receptor	Metabolic Disease
Ibipinabant (SLV319) is a potent, selective and orally active antagonist of cannabinoid CB1 receptor, with a K_i of 7.8 nM. Ibipinabant shows more than 1000-fold selectivity for CB1 over CB2 (K_i=7943 nM). Ibipinabant can be used for the research of obesity and diabetic ^[1] .

HY-130311

2-Linoleoyl glycerol 2-Monolinolein; 2-Monolinoleoylglycerol	Cannabinoid Receptor	Neurological Disease
2-Linoleoyl glycerol (2-Monolinolein) is a partial *CB1* receptor agonist with a pEC₅₀ of 4.781. 2-Linoleoyl glycerol activates the hCB1 receptor. 2-Linoleoyl glycerol does not induce an increase in intracellular free Ca ²⁺. 2-Linoleoyl glycerol can be used in the research of neurological disorders ^[1] .

HY-110036

GW-405833 L768242	Cannabinoid Receptor Endogenous Metabolite HIF/HIF Prolyl-Hydroxylase TNF Receptor Interleukin Related	Neurological Disease Inflammation/Immunology
GW-405833 (L768242) is a potent, selective cannabinoid receptor 2 (CB₂) agonist. GW405833 has EC₅₀ and K_i values of 0.65 nM and 3.92 nM for CB₂, and EC₅₀ and K_i values of 16.1 μM and 4772 nM for *CB₁. GW-405833 also exhibits non-competitive CB₁* antagonist, exerting its analgesic and and anti-inflammatory effect through a *CB₁* receptor (rather than CB₂) dependent mechanism. GW-405833 can significantly inhibit the production of cAMP stimulated by Forskolin (HY-15371). GW405833 inhibits glycolysis by down-regulating *HIF-1α*, thereby alleviating acute liver failure (ALF) ^[1] .

HY-10013A

Taranabant racemate MK-0364 racemate	Cannabinoid Receptor	Neurological Disease
Taranabant racemate (MK-0364 racemate) is an antagonist and/or inverse agonist of the *Cannabinoid-1* (CB1) receptor extracted from patent WO 2004048317 A1 ^[1].

HY-110018

N-Arachidonyldopamine	Cannabinoid Receptor TRP Channel	Neurological Disease
N-Arachidonyldopamine is a potent and selective endogenous **CB1 receptor agonist with a K_i of 250 nM ^[1]. N-Arachidonyldopamine is also a potent and selective TRPV1 agonist an with EC₅₀ of ~ 50 nM .**

HY-148137

CB1 agonist 1 1 Publications Verification	Cannabinoid Receptor	Neurological Disease
CB1 agonist 1 (compound 22) is an agonist of *CB1. CB1 agonist 1 shows affinity to CB1 receptor* with an pIC₅₀ value of 5.7. CB1 agonist 1 can be used for the research of brain disorders ^[1].

HY-117139

NESS 0327 1 Publications Verification	Cannabinoid Receptor	Neurological Disease
NESS 0327 is a cannabinoid antagonist with high selectivity for the cannabinoid CB1 receptor. NESS 0327 is more than 60,000-fold selective for the CB1 receptor ^[1].

HY-110003

Arachidonylcyclopropylamide 2 Publications Verification ACPA	Cannabinoid Receptor	Neurological Disease
Arachidonylcyclopropylamide (ACPA) is a potent and selective *CB1 receptors* agonist. Arachidonylcyclopropylamide inhibits forskolin-stimulated cAMP production in CHO cells transfected with human cannabinoid CB1 receptors (IC₅₀=2 nM) ^[1].

HY-103335

O1918 1 Publications Verification	Cannabinoid Receptor	Cardiovascular Disease
O1918 is a selective *non-CB₁ receptor* and GPR18 antagonist.

HY-118140

ZCZ011	Cannabinoid Receptor	Neurological Disease Inflammation/Immunology
ZCZ011 is a potent and brain-penetrant cannabinoid 1 (CB1) receptor positive allosteric modulator. ZCZ011 potentiates binding of CP55,940 to the CB1 receptor, enhances anandamide (AEA)-stimulated GTPγS binding in mouse brain membranes. ZCZ011 increases β-arrestin recruitment and ERK phosphorylation in hCB1 cells. ZCZ011 can be used for researching neuropathic and inflammatory pain ^[1].

HY-110047

CB65	Cannabinoid Receptor	Inflammation/Immunology
CB65 is a potent and high affinity CB2 selective agonist with a K_i value of 3.3 nM. CB65 exhibits a K_i of >1000 nM for CB1 receptor ^[1].

HY-141411A

Zevaquenabant (S)-MRI-1867	Cannabinoid Receptor NO Synthase	Metabolic Disease
Zevaquenabant ((S)-MRI-1867) is a peripherally restricted, orally bioavailable dual cannabinoid *CB1 receptor* and inducible NOS antagonist. Zevaquenabant ameliorates obesity-induced chronic kidney disease (CKD) ^[1].

HY-177425

AM11542	Cannabinoid Receptor	Metabolic Disease
AM11542 is a *cannabinoid receptor* 1** (CB1) agonist with a human CB1 K_i of 0.11 nM. AM11542 stabilizes the active conformational state of the CB1 receptor. AM11542 can be used for the research of obesity ^[1].

HY-124283A

LEI-101	Cannabinoid Receptor	Neurological Disease
LEI-101 is a potent, selective, and orally bioavailable cannabinoid CB2 receptor agonist, with a pEC₅₀ of 8 for hCB2, and a pK_i of less than 4 for hERG. LEI-101 is ~100-fold more potent in binding to CB2 receptors than to CB1 receptors ^[1] .

HY-B0151S2

Pregnenolone-d4-1 3β-Hydroxy-5-pregnen-20-one-d₄-1	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone-d₄-1 is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication ^[1] . Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

HY-125743

S-1 Methanandamide (S)-Methanandamide	Cannabinoid Receptor	Neurological Disease
S-1 Methanandamide ((S)-Methanandamide), an Anandamide analog, is a *CB1 receptor* ligand with a K_i of 173 nM. S-1 Methanandamide inhibits electrically-evoked twitch response in mouse vas deferens with an IC₅₀ value of 230 nM ^[1].

HY-14788

Drinabant AVE1625	Cannabinoid Receptor	Metabolic Disease
Drinabant (AVE1625) is an orally active *CB1 receptor* antagonist. Drinabant (AVE1625) inhibits the agonist-stimulated calcium signal with IC₅₀ values of 25 nM and 10 nM for the hCB1-R and rCB1-R, respectively, and is ineffective for the hCB2-R ^[1].

HY-112828

LEI105	DAGL	Neurological Disease Metabolic Disease Inflammation/Immunology
LEI105 is a potent, highly selective and reversible dual diacylglycerol lipase (DAGL)-α/DAGL-β inhibitor. LEI105 reduces 2-arachidonoylglycerol levels in Neuro2A cells. LEI105 also reduces cannabinoid CB1-receptor-mediated short-term synaptic plasticity in a mouse hippocampal slice model. LEI105 is promising for research of diseases, such as obesity, related metabolic disorders and neuroinflammation ^[1].

HY-159161

PSB-CB-27	Orphan GPCR	Inflammation/Immunology Cancer
PSB-CB-27 is a potent and selective GPR18 inhibitor with an IC₅₀ of 0.65 μM. PSB-CB-27 shows selectivity over Human GPR55, Human CB1 receptor, and Human CB2 receptor. PSB-CB-27 leads to a complete blockade of Δ9-Tetrahydrocannabinol (THC)-induced GPR18 activation. PSB-CB-27 can be used for inflammatory diseases and cancer immunotherapy research ^[1].

HY-103327

MJ15	Cannabinoid Receptor	Metabolic Disease
MJ15 is a potent and selective *CB1 receptor* antagonist with a K_i of 27.2 pM and an IC₅₀ of 118.9 pM for rat CB1 receptors. MJ15 exhibits potency in obesity and hyperlipidemia models. MJ15 inhibits food intake and increases in body weight in diet-induced obese rats and mice ^[1].

HY-110014

Noladin ether	Cannabinoid Receptor	Neurological Disease
Noladin ether is a potent and selective agonist of cannabinoid CB₁ receptor, with a K_i of 21.2 nM. Noladin ether can cause hypothermia, intestinal immobility, and mild antinociception ^[1].

HY-14753

Rosonabant	Cannabinoid Receptor	Cardiovascular Disease Metabolic Disease
Rosonabant is a selective antagonist for cannabinoid receptor (CB1 receptor), which reduces body weight and improves improves the risk of obesity-related cardiovascular metabolic diseases. Rosonabant exhibits adverse side effect, such as nausea and mental disorder ^[1].

HY-110189S1

Pregnenolone monosulfate-d4 sodium 3β-Hydroxy-5-pregnen-20-one monosulfate-d4 sodium	Isotope-Labeled Compounds Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone monosulfate-d₄ sodium is the deuterium labeled Pregnenolone monosulfate sodium (HY-110189) . Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication ^[1] . Pregnenolone monosulfate sodium is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

HY-110194

Virodhamine TFA	Endogenous Metabolite Cannabinoid Receptor	Neurological Disease
Virodhamine TFA is an endocannabinoid, it regulates neurotransmission by activating the cannabinoid (CB) receptors. Virodhamine is an antagonist of CB1 receptor and an agonist of CB2 receptor. Virodhamine TFA induces megakaryocytic differentiation by triggering MAPK signaling and ROS production. Virodhamine TFA can be used for the research of various neurological disorders such as Alzheimer's and Parkinson's diseases ^[1] .

HY-110036A

GW405833 hydrochloride L768242 hydrochloride	Cannabinoid Receptor Endogenous Metabolite HIF/HIF Prolyl-Hydroxylase TNF Receptor Interleukin Related	Neurological Disease Inflammation/Immunology
GW405833 (L768242) hydrochloride is a potent, selective cannabinoid receptor 2 (CB₂) agonist. GW405833 has EC₅₀ and K_i values of 0.65 nM and 3.92 nM for CB₂, and EC₅₀ and K_i values of 16.1 μM and 4772 nM for *CB₁. GW405833 hydrochloride also exhibits non-competitive CB₁* antagonist, exerting its analgesic effect through a *CB₁* receptor (rather than CB₂) dependent mechanism. GW405833 hydrochloride can significantly inhibit the production of cAMP stimulated by Forskolin (HY-15371). GW405833 hydrochloride inhibits glycolysis by down-regulating *HIF-1α*, thereby alleviating acute liver failure (ALF) ^[1] .

HY-183113

CB1-receptor agonist-1	Cannabinoid Receptor	Neurological Disease
CB1-receptor agonist-1 is the racemic form of compound ‘1350 and is also a **cannabinoid-1 receptor (CB1R)** agonist ^[1].

HY-128040

Virodhamine hydrochloride	Endogenous Metabolite Cannabinoid Receptor	Neurological Disease
Virodhamine (hydrochloride) is a cannabinoid *CB1* receptor partial agonist and cannabinoid CB2 receptor full agonist ^[1].

HY-N6097

Amauromine	Cannabinoid Receptor	Neurological Disease
Amauromine is a peripheral selective cannabinoid receptor type 1 (CB1) receptor antagonist with K_i and K_b values of 178 nM and 66.6 nM, respectively ^[1].

HY-12606

BMS-812204	Cannabinoid Receptor	Metabolic Disease
BMS-812204 is a highly selective *CB-1 receptor* antagonist. BMS-812204 is promising for research of obesity and metabolic disorders ^[1].

HY-105238

JHU-75528	Cannabinoid Receptor	Neurological Disease
JHU-75528 is a novel ligand of the cannabinoid receptor (CB1). JHU-75528 can be used in the research of imaging CB1 receptor ^[1].

HY-110179

PSNCBAM-1	Cannabinoid Receptor	Metabolic Disease
PSNCBAM-1 is a selective *CB1 receptor* allosteric antagonist with an EC₅₀ of 0.1 μM. PSNCBAM-1 can be used in the researches of obesity ^[1].

HY-114880

AB-FUBINACA 3-fluorobenzyl isomer	Cannabinoid Receptor	Neurological Disease
AB-FUBINACA 3-fluorobenzyl isomer is a synthetic cannabinoid that belongs to the indole derivatives and has a high affinity for the central *CB1* receptors (K_i= 0.9 nM), exhibiting anticonvulsant activity ^[1].

HY-B0151S

Pregnenolone-d4 3β-Hydroxy-5-pregnen-20-one-d₄	Isotope-Labeled Compounds Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone-d₄ is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication ^[1] . Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

HY-B0151S1

Pregnenolone-13C2,d2 3β-Hydroxy-5-pregnen-20-one-¹³C₂,d₂	Isotope-Labeled Compounds Autophagy Cannabinoid Receptor Endogenous Metabolite TRP Channel	Neurological Disease
Pregnenolone- ¹³C₂,d₂ is the deuterium and ¹³C labeled Pregnenolone (HY-B0151). Pregnenolone is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels ^[1] .

HY-121827

LH21 1 Publications Verification	Cannabinoid Receptor	Metabolic Disease
LH-21 is a potent in vivo neutral cannabinoid *CB1 receptor* antagonist. LH-21 reduces food intake and body weight gain in obese Zucker rats. , and displays efficacy as a feeding inhibitor ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P1397A

RVD-Hpα TFA	Cannabinoid Receptor	Cardiovascular Disease
RVD-Hpα TFA is the N-terminally extended form of human hemopressin that acts as a selective *CB1 receptor* agonist. RVD-Hpα TFA increases intracellular Ca ²⁺ levels in cells expressing CB1 receptors in vitro. RVD-Hpα TFA also high affinity CB2 positive allosteric modulator (K_i=50 nM).

HY-P11831

RD-pepcan-11	Cannabinoid Receptor PERK	Inflammation/Immunology
RD-pepcan-11 is a *CB1* receptor agonist. RD-pepcan-11 increases the relative phosphorylation level of *ERK1/2. RD-pepcan-11 mediates analgesic effects through interaction with CB1* receptors in a carrageenan-induced mouse inflammatory pain model. RD-pepcan-11 can be used in studies related to inflammatory pain ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0151

Pregnenolone Maximum Cited Publications 6 Publications Verification 3β-Hydroxy-5-pregnen-20-one	Microorganisms Neurological Disease Classification of Application Fields Anti-aging Endogenous metabolite Disease Research Fields Steroids Source Classification	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy
Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the *CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication ^[1] . Pregnenolone is also a TRPM3 channel* activator, and also can weakly activate TRPM1 channels .

HY-B1739

Pregnenolone monosulfate Maximum Cited Publications 6 Publications Verification 3β-Hydroxy-5-pregnen-20-one monosulfate	Endogenous metabolite Steroids Source Classification	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy
Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the *CB1 receptors. Pregnenolone monosulfate can protect the brain from cannabis intoxication ^[1] . Pregnenolone monosulfate is also a TRPM3 channel* activator, and also can weakly activate TRPM1 channels .

HY-116637

Tetrahydromagnolol Magnolignan	Classification of Application Fields Magnoliaceae Phenols Polyphenols Magnolia Liliflora Desr. Plants Inflammation/Immunology Disease Research Fields Source Classification	Cannabinoid Receptor GPR55 Drug Metabolite
Tetrahydromagnolol (Magnolignan), the main metabolite of Magnolol, is a potent and selective cannabinoidCB2 receptor agonist (EC₅₀ =170 nM) and GPR55 antagonist. The K_i of Tetrahydromagnolol for CB2 is 416 nM, 20-fold higher than for the CB1 receptor. Magnolol shows antifungal, anti-inflammatory and analgesic effects ^[1] .

HY-N0919

Yangonin 1 Publications Verification	other families Classification of Application Fields Other Phenylpropanoids Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields Source Classification	Cannabinoid Receptor NF-κB Autophagy
Yangonin exhibits affinity for the human recombinant cannabinoid *CB1 receptor* with an IC₅₀ and a K_i of 1.79 μM and 0.72 μM, respectively.

HY-110189

Pregnenolone monosulfate sodium Maximum Cited Publications 6 Publications Verification 3β-Hydroxy-5-pregnen-20-one monosulfate sodium	Endogenous metabolite Steroids Source Classification	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy
Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the *CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication ^[1] . Pregnenolone monosulfate sodium is also a TRPM3 channel* activator, and also can weakly activate TRPM1 channels .

HY-113204

N-Oleoyl glycine 2 Publications Verification	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Cannabinoid Receptor Akt
N-Oleoyl glycine is a lipoamino acid, which stimulates adipogenesis associated with activation of *CB1 receptor* and Akt signaling pathway in 3T3-L1 adipocyte.

HY-B0151R

Pregnenolone (Standard) 5 Publications Verification 3β-Hydroxy-5-pregnen-20-one (Standard)	Neurological Disease Classification of Application Fields Anti-aging Endogenous metabolite Disease Research Fields Steroids Source Classification	Reference Standards Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy
Pregnenolone (Standard) is the analytical standard of Pregnenolone. This product is intended for research and analytical applications. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the *CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication ^[1] . Pregnenolone is also a TRPM3 channel* activator, and also can weakly activate TRPM1 channels .

HY-N6097

Amauromine	Alkaloids Microorganisms Indole Alkaloids Source Classification	Cannabinoid Receptor
Amauromine is a peripheral selective cannabinoid receptor type 1 (CB1) receptor antagonist with K_i and K_b values of 178 nM and 66.6 nM, respectively ^[1].

HY-113516

20-HETE Ethanolamide	Alkaloids Neurological Disease Classification of Application Fields Other Alkaloids Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
20-HETE Ethanolamide is a metabolite of endocannabinoid Anandamide. 20-HETE Ethanolamide binds to the rat brain cannabinoid CB1 receptor with a K_i of 985 nM ^[1] .

HY-N0919R

Yangonin (Standard)	Structural Classification other families Other Phenylpropanoids Phenylpropanoids Plants Source Classification	Reference Standards Cannabinoid Receptor NF-κB Autophagy
Yangonin (Standard) is the analytical standard of Yangonin. This product is intended for research and analytical applications. Yangonin exhibits affinity for the human recombinant cannabinoid CB1 receptor with an IC50 and a Ki of 1.79 μM and 0.72 μM, respectively.

HY-110189R

Pregnenolone monosulfate sodium (Standard) 3β-Hydroxy-5-pregnen-20-one monosulfate sodium (Standard)	Structural Classification Endogenous metabolite Steroids Source Classification	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy Reference Standards
Pregnenolone monosulfate (sodium) (Standard) is the analytical standard of Pregnenolone monosulfate (sodium). This product is intended for research and analytical applications. Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication ^[1] . Pregnenolone monosulfate sodium is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

HY-N15177

Δ9-THCB Δ9-Tetrahydrocannabutol	Monophenols Cannabis sativa L Phenols Plants Moraceae Source Classification	Cannabinoid Receptor
Δ9-THCB (Δ9-Tetrahydrocannabutol) has a high affinity for human *CB1* and CB2 receptors with the K_i values of 15 nM and 51 nM, respectively. Δ9-THCB (Δ9-Tetrahydrocannabutol) has analgesic and anti-inflammatory activities and plays partial agonistic effects on *CB1* receptor in mice ^[1].

Cat. No.	Product Name	Chemical Structure

HY-B0151S2

Pregnenolone-d4-1

Pregnenolone-d₄-1 is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication ^[1] . Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

HY-110189S1

Pregnenolone monosulfate-d4 sodium

Pregnenolone monosulfate-d₄ sodium is the deuterium labeled Pregnenolone monosulfate sodium (HY-110189) . Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication ^[1] . Pregnenolone monosulfate sodium is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

HY-B0151S

Pregnenolone-d4

Pregnenolone-d₄ is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication ^[1] . Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

HY-B0151S1

Pregnenolone-13C2,d2

Pregnenolone- ¹³C₂,d₂ is the deuterium and ¹³C labeled Pregnenolone (HY-B0151). Pregnenolone is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels ^[1] .

HY-W705168

Yangonin-d3
Yangonin-d₃ is the deuterium labeled Yangonin (HY-N0919). Yangonin exhibits affinity for the human recombinant cannabinoid CB1 receptor with an IC₅₀ and a Ki of 1.79 μM and 0.72 μM, respectively.

HY-110189S

Pregnenolone monosulfate sodium-13C2,d2

Pregnenolone monosulfate (sodium)- ¹³C₂,d₂ is the ¹³C- and deuterium labeled Pregnenolone monosulfate sodium. Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium salt acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium salt can protect the brain from cannabis intoxication ^[1] . Pregnenolone monosulfate sodium salt is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

HY-114826S

Prostaglandin E2-1-glyceryl ester-d5
Prostaglandin E2-1-glyceryl ester-d₅ (PGE2-1-glyceyl ester-d₅) is deuterium labeled Prostaglandin E2-1-glyceryl ester. Prostaglandin E2-1-glyceryl ester, a Prostaglandin Glycerol Ester, is an endocannabinoid ligand for the *CB₁ receptor*. Prostaglandin E2-1-glyceryl ester induces rapid, transient elevation of intracellular free Ca ²⁺ ^[1] .

HY-W770198

2-Linoleoyl glycerol-d5

2-Linoleoyl glycerol-d₅ (2-Monolinolein-d₅; 2-Monolinoleoylglycerol-d₅) is the deuterium labeled 2-Linoleoyl glycerol (HY-130311). 2-Linoleoyl glycerol (2-Monolinolein; 2-Monolinoleoylglycerol) is a monoacylglycerol that is an antagonist and partial agonist at the type 1 cannabinoid CB1 receptor. The potency of 2-Linoleoyl glycerol can be enhanced by JZL195 (HY-15250), an inhibitor of FAAH and MAGL, and inhibited by the CB1 antagonist AM251 (HY-15443) and Cannabidiol. As a CB1 antagonist, 2-Linoleoyl glycerol does not enhance, but only attenuates, the activity of the CB1/CB2 receptor ligands cannabinoids (AEA) and 2-arachidonoylglycerol (2-AG) ^[1] .

HY-B0151S3

Pregnenolone-d6

Pregnenolone-d₆ (3β-Hydroxy-5-pregnen-20-one-d₆) is the deuterium labeled Pregnenolone (HY-B0151) ^[1]. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication . Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

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